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HIVAN

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https://www.readbyqxmd.com/read/27811066/transmembrane-tnf-%C3%AE-facilitates-hiv-1-infection-of-podocytes-cultured-from-children-with-hiv-associated-nephropathy
#1
Jinliang Li, Jharna R Das, Pingtao Tang, Zhe Han, Jyoti K Jaiswal, Patricio E Ray
Studies have shown that podocytes and renal tubular epithelial cells from patients with HIV-associated nephropathy (HIVAN) express HIV-1 transcripts, suggesting that productive infection of renal epithelial cells precipitates development of HIVAN. However, podocytes and renal tubular epithelial cells do not express CD4 receptors, and it is unclear how these cells become productively infected in vivo We investigated the mechanisms underlying the infection by HIV-1 of podocytes cultured from the urine of children with HIVAN...
November 3, 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/27736906/refinement-of-the-hivan1-susceptibility-locus-on-chr-3a1-a3-via-generation-of-sub-congenic-strains
#2
Natalia Papeta, Ami Patel, Vivette D D'Agati, Ali G Gharavi
HIV-1 transgenic mice on the FVB/NJ background (TgFVB) represent a validated model of HIV-associated nephropathy (HIVAN). A major susceptibility locus, HIVAN1, was previously mapped to chromosome 3A1-A3 in a cross between TgFVB and CAST/EiJ (CAST) strains, and introgression of a 51.9 Mb segment encompassing HIVAN1 from CAST into TgFVB resulted in accelerated development of nephropathy. We generated three sub-congenic strains carrying CAST alleles in the proximal or distal regions of the HIVAN1 locus (Sub-II, 3...
2016: PloS One
https://www.readbyqxmd.com/read/27695357/update-on-current-management-of-chronic-kidney-disease-in-patients-with-hiv-infection
#3
Nina E Diana, Saraladevi Naicker
The prevalence of HIV-associated chronic kidney disease (CKD) varies geographically and depends on the definition of CKD used, ranging from 4.7% to 38% globally. The incidence, however, has decreased with the use of effective combined antiretroviral therapy (cART). A wide variety of histological patterns are seen in HIV-associated kidney diseases that include glomerular and tubulointerstitial pathology. In resource-rich settings, there has been a plateau in the incidence of end-stage renal disease secondary to HIV-associated nephropathy (HIVAN)...
2016: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/27621665/interstitial-nephritis-caused-by-hiv-infection-by-itself-a-case-report
#4
Asako Doi, Kentaro Iwata, Shigeo Hara, Yukihiro Imai, Toshikazu Hasuike, Hiroaki Nishioka
Interstitial nephritis is a common cause of renal dysfunction. It is primarily caused by drugs, infections, or autoimmune disorders. Patients with human immunodeficiency virus (HIV) infection can develop interstitial nephritis, although it typically occurs because of the aforementioned etiologies and not as a direct consequence of HIV infection. Interstitial lesions may occur in patients with HIV-associated nephropathy (HIVAN). However, interstitial nephritis without the glomerular injuries characteristic of HIVAN, and without the risk factors described earlier, is very rare...
2016: International Journal of General Medicine
https://www.readbyqxmd.com/read/27599995/impact-of-apol1-polymorphism-and-il-1%C3%AE-priming-in-the-entry-and-persistence-of-hiv-1-in-human-podocytes
#5
Joanna Mikulak, Ferdinando Oriolo, Federica Portale, Paolo Tentorio, Xiqian Lan, Moin A Saleem, Karl Skorecki, Pravin C Singhal, Domenico Mavilio
BACKGROUND: Patients of African ancestry with untreated HIV-1 infection and carrying the G1 or G2 kidney disease risk variants (Vs) at the APOL1 gene have a tenfold higher risk of developing HIV-associated nephropathy (HIVAN) compared to those with the non-risk wild type (WT) G0 variant. However, the mechanistic contribution of the APOL1 allelic state to kidney injury in HIV-1 infection remains to be elucidated. RESULTS: Non-risk WT APOL1 is associated with lower intracellular levels of HIV-1 in conditionally immortalized human podocytes, while the over expression of G1 or G2 risk Vs significantly increases viral accumulation...
2016: Retrovirology
https://www.readbyqxmd.com/read/27477363/ajkd-atlas-of-renal-pathology-hiv-associated-nephropathy%C3%A2-hivan
#6
Agnes B Fogo, Mark A Lusco, Behzad Najafian, Charles E Alpers
No abstract text is available yet for this article.
August 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/27469157/hiv-associated-renal-disease-an-overview
#7
Nicola Wearne, Ikechi G Okpechi
The cause of the human immunodeficiency virus (HIV) epidemic in South Africa (SA) was worsened by the denial by key political players that HIV causes acquired immunodeficiency syndrome (AIDS). South Africa continues to have the highest rate of HIV world-wide, which has had a huge impact on the development of both chronic kidney disease and acute kidney injury. Fortunately, there is now an effective antiretroviral therapy (ART) roll-out program. SA is also dealing with a collision of epidemics of HIV, tuberculosis, and non-communicable disease, particularly hypertension and diabetes...
2016: Clinical Nephrology
https://www.readbyqxmd.com/read/27163710/hiv-infection-induced-transcriptional-program-in-renal-tubular-epithelial-cells-activates-a-cxcr2-driven-cd4-t-cell-chemotactic-response
#8
Ping Chen, Zhengzi Yi, Weijia Zhang, Mary E Klotman, Benjamin K Chen
OBJECTIVE: Viral replication and interstitial inflammation play important roles in the pathogenesis of HIV-associated nephropathy. Cell-cell interactions between renal tubule epithelial cells (RTECs) and HIV-infected T cells can trigger efficient virus internalization and viral gene expression by RTEC. To understand how HIV replication initiates HIV-associated nephropathy, we studied the cellular response of RTECs to HIV, examining the transcriptional profiles of primary RTECs exposed to cell-free HIV or HIV-infected T cells...
July 31, 2016: AIDS
https://www.readbyqxmd.com/read/27097894/the-podocyte-as-a-direct-target-for-treatment-of-glomerular-disease
#9
Sandeep K Mallipattu, John C He
The Centers for Disease Control and Prevention estimates more than 10% of adults in the United States, over 20 million Americans, have chronic kidney disease (CKD). A failure to maintain the glomerular filtration barrier directly contributes to the onset of CKD. The visceral epithelial cells, podocytes, are integral to the maintenance of this renal filtration barrier. Direct podocyte injury contributes to the onset and progression of glomerular diseases such as minimal change disease (MCD), focal segmental glomerular sclerosis (FSGS), diabetic nephropathy, and HIV-associated nephropathy (HIVAN)...
July 1, 2016: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/27007656/multiple-facets-of-hiv-associated-renal-disease
#10
D R da Silva, I C Gluz, J Kurz, G G Thomé, R Zancan, R N Bringhenti, P G Schaefer, M Dos Santos, E J G Barros, F V Veronese
HIV infection has a broad spectrum of renal manifestations. This study examined the clinical and histological manifestations of HIV-associated renal disease, and predictors of renal outcomes. Sixty-one (64% male, mean age 45 years) HIV patients were retrospectively evaluated. Clinical presentation and renal histopathology were assessed, as well as CD4 T-cell count and viral load. The predictive value of histological lesion, baseline CD4 cell count and viral load for end-stage renal disease (ESRD) or death were determined using the Cox regression model...
2016: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/26786550/clinical-characteristics-and-outcomes-of-hiv-associated-immune-complex-kidney-disease
#11
John W Booth, Lisa Hamzah, Sophie Jose, Catherine Horsfield, Patrick O'Donnell, Stephen McAdoo, Emil A Kumar, Tabitha Turner-Stokes, Nadia Khatib, Partha Das, Claire Naftalin, Nicola Mackie, Ed Kingdon, Debbie Williams, Bruce M Hendry, Caroline Sabin, Rachael Jones, Jeremy Levy, Rachel Hilton, John Connolly, Frank A Post
BACKGROUND: The pathogenesis and natural history of HIV-associated immune complex kidney disease (HIVICK) is not well understood. Key questions remain unanswered, including the role of HIV infection and replication in disease development and the efficacy of antiretroviral therapy (ART) in the prevention and treatment of disease. METHODS: In this multicentre study, we describe the renal pathology of HIVICK and compare the clinical characteristics of patients with HIVICK with those with IgA nephropathy and HIV-associated nephropathy (HIVAN)...
January 18, 2016: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/26175146/trends-in-the-outcomes-of-end-stage-renal-disease-secondary-to-human-immunodeficiency-virus-associated-nephropathy
#12
Sarah Razzak Chaudhary, Biruh T Workeneh, Maria E Montez-Rath, Andrew R Zolopa, Paul E Klotman, Wolfgang C Winkelmayer
BACKGROUND: Little is known about the trends in the incidence and outcomes of patients with end-stage renal disease (ESRD) attributed to human immunodeficiency virus-associated nephropathy (HIVAN). We sought to define relative incidence among ESRD patients, changes in mortality among patients with ESRD attributed to HIVAN, as well as changes in the excess mortality experienced by patients with ESRD attributed to HIVAN compared with otherwise similar ESRD patients with non-HIVAN causes...
October 2015: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/26161174/prevalence-of-persistent-microalbuminuria-and-associated-factors-among-hiv-infected-children-attending-a-tertiary-hospital-in-northern-tanzania-a-cross-sectional-analytical-study
#13
Ignatus Kissima Mosten, Bernadus Carolus Hamel, Grace Damas Kinabo
INTRODUCTION: Human Immunodeficiency Virus (HIV) infection is a significant cause of paediatric morbidity and mortality especially in Sub-Saharan Africa. It affects the kidney by injuring the glomerular and tubular epithelial cells causing leakage of albumin in urine. Microalbuminuria is known to be an early indicator of kidney injury including HIVAN. The purpose of this study was to identify the prevalence and factors associated with microalbuminuria among HIV infected children receiving care and treatment at Kilimanjaro Christian Medical Centre (KCMC)...
2015: Pan African Medical Journal
https://www.readbyqxmd.com/read/26106375/apolipoprotein-l1-apol1-variants-vs-a-possible-link-between-heroin-associated-nephropathy-han-and-hiv-associated-nephropathy-hivan
#14
REVIEW
Xiqian Lan, T K S Rao, Praveen N Chander, Karl Skorecki, Pravin C Singhal
In 1970s, Heroin-associated Nephropathy (HAN), one form of focal and segmental glomerulosclerosis (FSGS), was a predominant cause of End-stage Kidney Disease (ESKD) in African-Americans (AAs). In 1980s, with the surge of Acquired Immune Deficiency Syndrome (AIDS) in AAs, HAN more or less disappeared, and the incidence of Human Immunodeficiency Virus associated Nephropathy (HIVAN) markedly increased. Recent studies in AAs have identified APOL1 variants (Vs) as a major risk factor for the development and progression of non-diabetic kidney diseases including idiopathic FSGS and hypertension-attributed nephrosclerosis...
2015: Frontiers in Microbiology
https://www.readbyqxmd.com/read/26079546/tubular-cell-phenotype-in-hiv-associated-nephropathy-role-of-phospholipid-lysophosphatidic-acid
#15
Kamesh R Ayasolla, Partab Rai, Shai Rahimipour, Mohammad Hussain, Ashwani Malhotra, Pravin C Singhal
Collapsing glomerulopathy and microcysts are characteristic histological features of HIV-associated nephropathy (HIVAN). We have previously reported the role of epithelial mesenchymal transition (EMT) in the development of glomerular and tubular cell phenotypes in HIVAN. Since persistent tubular cell activation of NFκB has been reported in HIVAN, we now hypothesize that HIV may be contributing to tubular cell phenotype via lysophosphatidic acid (LPA) mediated downstream signaling. Interestingly, LPA and its receptors have also been implicated in the tubular interstitial cell fibrosis (TIF) and cyst formation in autosomal dominant polycystic kidney disease (PKD)...
August 2015: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/26061701/outcomes-of-renal-transplantation-in-hiv-1-associated-nephropathy
#16
Sana Waheed, Ahmad Sakr, Neha D Chheda, Gregory M Lucas, Michelle Estrella, Derek M Fine, Mohamed G Atta
INTRODUCTION: Several studies have demonstrated that renal transplantation in HIV positive patients is both safe and effective. However, none of these studies have specifically examined outcomes in patients with HIV-associated nephropathy (HIVAN). METHODS: Medical records of all HIV-infected patients who underwent kidney transplantation at Johns Hopkins Hospital between September 2006 and January 2014 were reviewed. Data was collected to examine baseline characteristics and outcomes of transplant recipients with HIVAN defined pathologically as collapsing focal segmental glomerulosclerosis (FSGS) with tubulo-interstitial disease...
2015: PloS One
https://www.readbyqxmd.com/read/25993319/sequencing-rare-and-common-apol1-coding-variants-to-determine-kidney-disease-risk
#17
MULTICENTER STUDY
Sophie Limou, George W Nelson, Laurence Lecordier, Ping An, Colm S O'hUigin, Victor A David, Elizabeth A Binns-Roemer, Wilfried M Guiblet, Taras K Oleksyk, Etienne Pays, Jeffrey B Kopp, Cheryl A Winkler
A third of African Americans with sporadic focal segmental glomerulosclerosis (FSGS) or HIV-associated nephropathy (HIVAN) do not carry APOL1 renal risk genotypes. This raises the possibility that other APOL1 variants may contribute to kidney disease. To address this question, we sequenced all APOL1 exons in 1437 Americans of African and European descent, including 464 patients with biopsy-proven FSGS/HIVAN. Testing for association with 33 common and rare variants with FSGS/HIVAN revealed no association independent of strong recessive G1 and G2 effects...
October 2015: Kidney International
https://www.readbyqxmd.com/read/25949944/african-origins-and-chronic-kidney-disease-susceptibility-in-the-human-immunodeficiency-virus-era
#18
REVIEW
Alex N Kasembeli, Raquel Duarte, Michèle Ramsay, Saraladevi Naicker
Chronic kidney disease (CKD) is a major public health problem worldwide with the estimated incidence growing by approximately 6% annually. There are striking ethnic differences in the prevalence of CKD such that, in the United States, African Americans have the highest prevalence of CKD, four times the incidence of end stage renal disease when compared to Americans of European ancestry suggestive of genetic predisposition. Diabetes mellitus, hypertension and human immunodeficiency virus (HIV) infection are the major causes of CKD...
May 6, 2015: World Journal of Nephrology
https://www.readbyqxmd.com/read/25910411/the-association-of-rbbp6-variant-3-expressions-with-apoptosis-in-human-immunodeficiency-virus-associated-nephropathy-hivan
#19
Zukile Mbita, Sarala Naicker, Stewart Goetsch, Zodwa Dlamini
South Africa has one of the highest HIV infection rates in the world. One of the complications of HIV infection is the development of HIV-associated nephropathy (HIVAN), which is characterized by deregulation in tubular epithelial apoptosis. The pathways that HIV-1 promotes in the pathogenesis of HIVAN remain less understood. There are many genes that have not been characterized in the pathogenesis of HIVAN. On the other hand, RBBP6 has been shown to play a role in both promoting and inhibiting apoptosis in human cancers...
August 2015: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/25725239/hiv-and-chronic-kidney-disease
#20
REVIEW
Saraladevi Naicker, Sadaf Rahmanian, Jeffrey B Kopp
Chronic kidney disease (CKD) is a frequent complication of HIV infection, occurring in 3.5 - 48.5%, and occurs as a complication of HIV infection, other co-morbid disease and infections and as a consequence of therapy of HIV infection and its complications. The classic involvement of the kidney by HIV infection is HIV-associated nephropathy (HIVAN), occurring typically in young adults of African ancestry with advanced HIV disease in association with APOL1 high-risk variants. HIV-immune complex disease is the second most common diagnosis obtained from biopsies of patients with HIV-CKD...
2015: Clinical Nephrology
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