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https://www.readbyqxmd.com/read/27920815/early-onset-acute-tubular-necrosis-following-single-infusion-of-zoledronate
#1
Ralph Yachoui
Zoledronate is a highly potent bisphosphonate widely used in the treatment of postmenopausal osteoporosis. We report the first occurrence of toxic acute tubular necrosis (ATN) following treatment with zoledronate in a patient with osteoporosis. A 63-year-old Caucasian female with rheumatoid arthritis on anti-immune agents received a single dose of zoledronic acid (reclast) for worsening osteoporosis. Twelve days later, she developed renal failure with a rise in serum creatinine from a baseline level of 1.1 mg/dL to 5...
May 2016: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/27919705/the-complete-mitochondrial-genome-of-thitarodes-sejilaensis-lepidoptera-hepialidae-a-host-insect-of-ophiocordyceps-sinensis-and-its-implication-in-taxonomic-revision-of-hepialusadopted-in-china
#2
Zhiwen Zou, Qiang Min, Shiyu Cheng, Tianrong Xin, Bin Xia
The mitochondrial genome is widely used for phylogenetic analyses and evolutionary biology. The complete mitochondrial genome of Thitarodes sejilaensis (Lepidoptera: Hepialidae) was sequenced and analyzed in this study. This mitogenome is a typical circular molecule of 15,290bp, with the gene content, orientation and order identical to other insects in the family Hepialidae. The genome nucleotide composition is heavily biased towards As and Ts, accounting for 80.87% of total nucleotide content. The major strand shows a positive AT-skew and negative GC-skew...
December 2, 2016: Gene
https://www.readbyqxmd.com/read/27919615/anatomical-study-of-the-superficial-temporal-branches-of-the-auriculotemporal-nerve-application-to-surgery-and-other-invasive-treatments-to-the-temporal-region
#3
Joe Iwanaga, Koichi Watanabe, Tsuyoshi Saga, Christian Fisahn, Rod J Oskouian, R Shane Tubbs
BACKGROUND AND AIM: The auriculotemporal nerve (ATN) is one of the branches of the mandibular division of the trigeminal nerve, which gives rise to many branches to the retromandibular and temporal regions. Of these, the superficial temporal branch can occasionally be the cause of migraine headaches and auriculotemporal neuralgia. The purpose of this study was to elucidate the anatomy of the superficial temporal branch, which has never been described in detail. METHODS: A total of 14 sides of cadaveric heads were used for this study...
November 11, 2016: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/27894945/successful-treatment-of-refractory-status-epilepticus-using-anterior-thalamic-nuclei-deep-brain-stimulation
#4
Ching-Yi Lee, Siew-Na Lim, Tony Wu, Shih-Tseng Lee
BACKGROUND: Refractory status epilepticus(RSE) is considered a medical emergency in neurology and is related to a high mortality rate. We report a successfully treated case of RSE using deep brain stimulation (DBS) at the anterior thalamic nuclei (ATN). METHOD: Report concerning the resolution of RSE after DBS of the ATN in a 17-year-old woman RESULT: This patient developed RSE due to progressive seizure activity. RSE with generalized tonic-clonic seizures was noted two weeks prior to admission...
November 25, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27871857/bmi-1-plays-a-critical-role-in-the-protection-from-acute-tubular-necrosis-by-mobilizing-renal-stem-progenitor-cells
#5
Xianhui Lv, Zhenzhen Yu, Chunfeng Xie, Xiuliang Dai, Qing Li, Dengshun Miao, Jianliang Jin
The regeneration of injured tubular cell occurs primarily from intrinsic renal stem/progenitor cells (RSCs) labeled with CD24 and CD133 after acute tubular necrosis (ATN). Bmi-1 plays a crucial role in regulating self-renewal, differentiation and aging of multiple adult stem cells and progenitor cells. Bmi-1 was rapidly elevated in the induction of adult kidney regeneration by renal injury. To determine whether Bmi-1 maintained mobilization of RSCs in the protection from ATN, glycerol-rhabdomyolysis-induced ATN were performed in wild type (WT) and Bmi-1-deficient (Bmi-1(-/-)) mice...
November 18, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27861147/arctigenin-inhibits-stat3-and-exhibits-anticancer-potential-in-human-triple-negative-breast-cancer-therapy
#6
Tingting Feng, Wei Cao, Wanxiang Shen, Liang Zhang, Xinsheng Gu, Yang Guo, Hsiang-I Tsai, Xuewen Liu, Jian Li, Jingxuan Zhang, Shan Li, Fuyun Wu, Ying Liu
Triple-negative breast cancers (TNBCs) are the most aggressive and hard-to-treat breast tumors with poor prognosis, and exploration for novel therapeutic drugs is impending. Arctigenin (Atn), a bioactive lignan isolated from seeds of Arctium lappa L, has been reported to inhibit many cancer types; however, the effect of Atn on TNBC remains unclear. In this study, we demonstrated that Atn decreased proliferation, and induced apoptosis in TNBC cells. Furthermore, we explored the underlying mechanism of Atn inhibition on TNBC cells...
November 16, 2016: Oncotarget
https://www.readbyqxmd.com/read/27830427/factors-associated-with-self-injurious-behaviors-in-children-with-autism-spectrum-disorder-findings-from-two-large-national-samples
#7
G N Soke, S A Rosenberg, R F Hamman, T Fingerlin, C R Rosenberg, L Carpenter, L C Lee, E Giarelli, L D Wiggins, M S Durkin, A Reynolds, C DiGuiseppi
In this study, we explored potential associations among self-injurious behaviors (SIB) and a diverse group of protective and risk factors in children with autism spectrum disorder from two databases: Autism and Developmental Disabilities Monitoring (ADDM) Network and the Autism Speaks-Autism Treatment Network (AS-ATN). The presence of SIB was determined from children's records in ADDM and a parent questionnaire in AS-ATN. We used multiple imputation to account for missing data and a non-linear mixed model with site as a random effect to test for associations...
November 9, 2016: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/27822711/the-complete-mitogenome-of-a-jumping-spider-carrhotus-xanthogramma-araneae-salticidae-and-comparative-analysis-in-four-salticid-mitogenomes
#8
Wen-Yuan Fang, Zheng-Liang Wang, Chao Li, Xiao-Qing Yang, Xiao-Ping Yu
The complete mitogenome of the jumping spider Carrhotus xanthogramma was determined and comparative analysis among four salticid mitogenomes was conducted. The circular genome is 14,563 bp in size and contains a complete set of genes that usually present in the metazoa. All of the 13 protein-coding genes begin with a typical ATN codon and stop with the canonical stop codons, except for ND4 and ND4L genes with an incomplete stop codon T. All of the tRNAs cannot be formed the fully paired acceptor stems and seven out of them cannot be folded into the typical cloverleaf-shaped secondary structures...
December 2016: Genetica
https://www.readbyqxmd.com/read/27809280/role-of-oxidative-stress-in-drug-induced-kidney-injury
#9
REVIEW
Keiko Hosohata
The kidney plays a primary role in maintaining homeostasis and detoxification of numerous hydrophilic xenobiotics as well as endogenous compounds. Because the kidney is exposed to a larger proportion and higher concentration of drugs and toxins than other organs through the secretion of ionic drugs by tubular organic ion transporters across the luminal membranes of renal tubular epithelial cells, and through the reabsorption of filtered toxins into the lumen of the tubule, these cells are at greater risk for injury...
November 1, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27788506/overexpression-of-intrarenal-renin-angiotensin-system-in-human-acute-tubular-necrosis
#10
Wei Cao, Lingwei Jin, Zhanmei Zhou, Manqiu Yang, Chunyi Wu, Liling Wu, Shuang Cui
BACKGROUND/AIMS: Acute tubular necrosis (ATN), a leading cause of acute kidney injury (AKI), is associated with decreased survival and increased progression of chronic kidney disease. A barrier to improving the clinical outcomes is the incomplete understanding of the pathogenesis of AKI. Our objective is to test the hypothesis that intrarenal renin-angiotensin system (RAS) is overexpressed in patients with ATN and could be an indicator of ATN severity. METHODS: A transversal study was conducted in patients with biopsy-proven ATN...
October 28, 2016: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/27785593/communication-deficits-and-the-motor-system-exploring-patterns-of-associations-in-autism-spectrum-disorder-asd
#11
M Mody, A M Shui, L A Nowinski, S B Golas, C Ferrone, J A O'Rourke, C J McDougle
Many children with autism spectrum disorder (ASD) have notable difficulties in motor, speech and language domains. The connection between motor skills (oral-motor, manual-motor) and speech and language deficits reported in other developmental disorders raises important questions about a potential relationship between motor skills and speech-language deficits in ASD. To this end, we examined data from children with ASD (n = 1781), 2-17 years of age, enrolled in the Autism Speaks-Autism Treatment Network (AS-ATN) registry who completed a multidisciplinary evaluation that included diagnostic, physical, cognitive and behavioral assessments as part of a routine standard of care protocol...
October 26, 2016: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/27770241/the-complete-mitochondrial-genome-of-trabala-vishnou-guttata-lepidoptera-lasiocampidae-and-the-related-phylogenetic-analyses
#12
Liuyu Wu, Xiao Xiong, Xuming Wang, Tianrong Xin, Jing Wang, Zhiwen Zou, Bin Xia
The bluish yellow lappet moth, Trabala vishnou guttata is an extraordinarily important pest in China. The complete mitochondrial genome is sequenced and determined firstly, which is based on traditional PCR amplification and primer walking methods with a length of 15,281 bp, including 13 protein-coding (PCG) genes, 22 transfer RNA (rRNA) genes, two ribosomal RNA (tRNA) genes, and an A + T-rich region. The gene order and orientation of the T. vishnou guttata mitogenome were identical to the other sequenced Lasiocampidae species...
December 2016: Genetica
https://www.readbyqxmd.com/read/27767191/the-first-complete-mitochondrial-genome-for-the-subfamily-limacodidae-and-implications-for-the-higher-phylogeny-of-lepidoptera
#13
Qiu-Ning Liu, Zhao-Zhe Xin, Dan-Dan Bian, Xin-Yue Chai, Chun-Lin Zhou, Bo-Ping Tang
The mitochondrial genome (mitogenome) provides important information for understanding molecular evolution and phylogeny. To determine the systematic status of the family Limacodidae within Lepidoptera, we infer a phylogenetic hypothesis based on the complete mitogenome of Monema flavescens (Lepidoptera: Limacodidae). The mitogenome of M. flavescens is 15,396 base pairs (bp), and includes 13 protein-coding genes (PCGs), two ribosomal RNA (rRNA) genes, 22 transfer RNA (tRNA) genes, and a control region (CR)...
October 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27738777/histopathological-changes-in-septic-acute-kidney-injury-in-critically-ill-children-a-cohort-of-post-mortem-renal-biopsies
#14
Ramachandran Rameshkumar, Sriram Krishnamurthy, Rajesh Nachiappa Ganesh, Subramanian Mahadevan, Parameswaran Narayanan, Ponnarmeni Satheesh, Puneet Jain
BACKGROUND: Septic acute kidney injury (AKI) accounts for more than half of all cases of AKI in critically ill children. The renal histology was found to alter the management in more than two-third of cases of adult acute renal failure. Better insight into the pathogenesis of pediatric septic AKI could be based on developing a clearer appreciation of the histopathological changes. No comprehensive study of the histopathological features of septic AKI in critically ill children has yet been performed...
October 13, 2016: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/27729618/antibody-based-pet-of-upa-upar-signaling-with-broad-applicability-for-cancer-imaging
#15
Dongzhi Yang, Gregory W Severin, Casey A Dougherty, Rachel Lombardi, Daiqin Chen, Marcian E Van Dort, Todd E Barnhart, Brian D Ross, Andrew P Mazar, Hao Hong
Mounting evidence suggests that the urokinase plasminogen activator (uPA) and its receptor (uPAR) play a central role in tumor progression. The goal of this study was to develop an 89Zr-labeled, antibody-based positron emission tomography (PET) tracer for quantitative imaging of the uPA/uPAR system. An anti-uPA monoclonal antibody (ATN-291) was conjugated with a deferoxamine (Df) derivative and subsequently labeled with 89Zr. Flow cytometry, microscopy studies, and competitive binding assays were conducted to validate the binding specificity of Df-ATN-291 against uPA...
October 8, 2016: Oncotarget
https://www.readbyqxmd.com/read/27694403/analysis-on-the-complete-mitochondrial-genome-of-andraca-theae-lepidoptera-bombycoidea
#16
Xing-Shi Gu, Li Ma, Xing Wang, Guo-Hua Huang
The bombycid moth, Andraca theae (Matsumura) (Lepidoptera: Bombycoidea) is an important pest of tea in southeastern China. In the present study, the mitochondrial genome (mitogenome) of A. theae was amplified by polymerase chain reaction and sequenced. The complete mitogenome of A. theae, encoding 37 genes, was 15,737 bp in length (Genbank no. KX365419), and consisted of 13 protein-coding genes (PCGs), 22 tRNA genes, 2 ribosomal RNA genes and an adenine (A) + thymine (T)-rich region (AT-rich region). The gene order of A...
2016: Journal of Insect Science
https://www.readbyqxmd.com/read/27648767/the-rearranged-mitochondrial-genome-of-leptopilina-boulardi-hymenoptera-figitidae-a-parasitoid-wasp-of-drosophila
#17
Daniel S Oliveira, Tiago M F F Gomes, Elgion L S Loreto
The partial mitochondrial genome sequence of Leptopilina boulardi (Hymenoptera: Figitidae) was characterized. Illumina sequencing was used yielding 35,999,679 reads, from which 102,482 were utilized in the assembly. The length of the sequenced region of this partial mitochondrial genome is 15,417 bp, consisting of 13 protein-coding, two rRNA, and 21tRNA genes (the trnaM failed to be sequenced) and a partial A+T-rich region. All protein-coding genes start with ATN codons. Eleven protein-coding genes presented TAA stop codons, whereas ND6 and COII that presented TA, and T nucleotides, respectively...
September 19, 2016: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/27632233/an-hiv-preexposure-prophylaxis-demonstration-project-and-safety-study-for-young-msm
#18
Sybil G Hosek, Bret Rudy, Raphael Landovitz, Bill Kapogiannis, George Siberry, Brandy Rutledge, Nancy Liu, Jennifer Brothers, Kathleen Mulligan, Gregory Zimet, Michelle Lally, Kenneth H Mayer, Peter Anderson, Jennifer Kiser, James F Rooney, Craig M Wilson
BACKGROUND: Young men who have sex with men (YMSM) are a key population for implementation of preexposure prophylaxis (PrEP) interventions. This open-label study examined adherence to PrEP and assessed sexual behavior among a diverse sample of YMSM in 12 US cities. METHODS: Eligible participants were 18- to 22-year-old HIV-uninfected MSM who reported HIV transmission risk behavior in the previous 6 months. Participants were provided daily tenofovir disoproxil fumarate/emtricitabine (Truvada)...
January 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27624727/using-syndemics-theory-to-investigate-risk-and-protective-factors-associated-with-condomless-sex-among-youth-living-with-hiv-in-17-u-s-cities
#19
Jacob J van den Berg, M Isabel Fernández, Joseph L Fava, Don Operario, Bret J Rudy, Patrick A Wilson
Identifying risk and protective factors associated with condomless sex among youth living with HIV is imperative for developing effective HIV prevention strategies. A cross-sectional sample of 1728 participants, 12-26 years of age, recruited from adolescent medicine clinics in 17 U.S. cities completed an audio-computer assisted self-interview with questions about their substance use, psychosocial factors, and attitudinal and behavioral factors. Guided by syndemics theory, a path analysis was used to assess the interrelations of these factors...
September 13, 2016: AIDS and Behavior
https://www.readbyqxmd.com/read/27604597/tn-muc1-dc-vaccination-of-rhesus-macaques-and-a-phase-i-ii-trial-in-patients-with-nonmetastatic-castrate-resistant-prostate-cancer
#20
Elizabeth Scheid, Pierre Major, Alain Bergeron, Olivera J Finn, Russell D Salter, Robin Eady, Bader Yassine-Diab, David Favre, Yoav Peretz, Claire Landry, Sebastien Hotte, Som D Mukherjee, Gregory A Dekaban, Corby Fink, Paula J Foster, Jeffery Gaudet, Jean Gariepy, Rafick-Pierre Sekaly, Louis Lacombe, Yves Fradet, Ronan Foley
MUC1 is a glycoprotein expressed on the apical surface of ductal epithelial cells. Malignant transformation results in loss of polarization and overexpression of hypoglycosylated MUC1 carrying truncated carbohydrates known as T or Tn tumor antigens. Tumor MUC1 bearing Tn carbohydrates (Tn-MUC1) represent a potential target for immunotherapy. We evaluated the Tn-MUC1 glycopeptide in a human phase I/II clinical trial for safety that followed a preclinical study of different glycosylation forms of MUC1 in rhesus macaques, whose MUC1 is highly homologous to human MUC1...
October 2016: Cancer Immunology Research
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