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https://www.readbyqxmd.com/read/28420814/cell-adhesion-molecule-1-cadm1-expressed-on-adult-t-cell-leukemia-lymphoma-cells-is-not-involved-in-the-interaction-with-macrophages
#1
Yoshihiro Komohara, Chaoya Ma, Hiromu Yano, Cheng Pan, Hasita Horlad, Yoichi Saito, Koji Ohnishi, Yukio Fujiwara, Yutaka Okuno, Kisato Nosaka, Shunsuke Shimosaki, Kazuhiro Morishita, Masao Matsuoka, Tomohiko Wakayama, Motohiro Takeya
Cell adhesion molecule 1 (CADM1) is a cell adhesion molecule that is expressed in brain, liver, lung, testis, and some kinds of cancer cells including adult T-cell leukemia/lymphoma (ATLL). Recent studies have indicated the involvement of CADM1 in cell-cell contact between cytotoxic T-lymphocytes and virus infected cells. We previously reported that cell-cell interaction between lymphoma cells and macrophages induces lymphoma cell proliferation. In the present study, we investigated whether CADM1 is associated with cell-cell interaction between several human lymphoma cell lines and macrophages...
April 18, 2017: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/28416924/comparison-of-second-and-third-generation-nails-in-the-treatment-of-intertrochanteric-fracture-screws-versus-helical-blades
#2
Mert Kumbaraci, Levent Karapinar, Ali Turgut
OBJECTIVE: The aim of this study was to compare the radiological and functional outcomes of anti-rotation trochanteric nails (ATNs) with proximal femoral nail anti-rotation (PFNA) in the treatment of intertrochanteric femur fractures in elderly patients. MATERIALS AND METHODS: In total, 165 intertrochanteric fractures were treated between January 2007 and January 2010. One hundred forty patients were included. The operation time, amount of blood loss, fluoroscopy screening time, and length of hospitalization were recorded...
February 2017: Eurasian Journal of Medicine
https://www.readbyqxmd.com/read/28366875/dual-role-of-muc1-mucin-in-kidney-ischemia-reperfusion-injury-nephroprotector-in-early-phase-but-pro-fibrotic-in-late-phase
#3
Jean-Baptiste Gibier, Brigitte Hémon, Mélanie Fanchon, Kelly Gaudelot, Nicolas Pottier, Bélinda Ringot, Isabelle Van Seuningen, François Glowacki, Christelle Cauffiez, David Blum, Marie-Christine Copin, Michaël Perrais, Viviane Gnemmi
Acute kidney injury (AKI) is characterized by acute tubular necrosis (ATN) which involves mainly proximal tubules. Past AKI is associated with higher risk of chronic kidney disease (CKD). The MUC1 mucin is a large glycoprotein responsible for epithelial protection and locates to convoluted distal tubules and collecting ducts. Since MUC1 activates the epithelial-mesenchymal transition (EMT) in carcinoma cells, we hypothesized that MUC1 could be involved in epithelial tubular cell plasticity, a process that accompanies epithelial repair, but also participates into kidney fibrosis, histological substratum of CKD...
March 30, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28361753/handgrip-strength-and-weight-predict-long-term-mortality-in-acute-kidney-injury-patients
#4
S P Xavier, C R Goes, M N B Bufarah, A L Balbi, D Ponce
INTRODUCTION: Surviving acute kidney (AKI) patients have a higher late mortality compared with those admitted without AKI. The negative impact of malnutrition on the early outcome of AKI patients has recently been confirmed by various studies. However, its impact after hospital discharge has not been studied. The objective of the study was to determine the role of anthropometric measurements and handgrip strength as predictors of mortality 180 days after discharge. METHODOLOGY: Eighty-two survivors AKI patients who were older than 18 y old and followed by AKI team were prospectively evaluated...
February 2017: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28358337/neoantimycins-a-and-b-two-unusual-benzamido-nine-membered-dilactones-from-marine-derived-streptomyces-antibioticus-h12-15
#5
Chen Hu, Shi-Wen Zhou, Fang Chen, Xin-Heng Zheng, Hui-Fang Shen, Bi-Run Lin, Guang-Xiong Zhou
An actinomycete strain (H12-15) isolated from a sea sediment in a mangrove district was identified as Streptomycesantibioticus on the basis of 16S rDNA gene sequence analysis as well as the investigation of its morphological, physiological, and biochemical characteristics. Two novel benzamido nonacyclic dilactones, namely neoantimycins A (1) and B (2), together with the known antimycins A1ab (3a,b), A2a (4), and A₉ (5), were isolated from the culture broth of this strain. Compounds 1 and 2 are the first natural modified ATNs with an unusual benzamide unit...
March 30, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28321178/post-training-inactivation-of-the-anterior-thalamic-nuclei-impairs-spatial-performance-on-the-radial-arm-maze
#6
Ryan E Harvey, Shannon M Thompson, Lilliana M Sanchez, Ryan M Yoder, Benjamin J Clark
The limbic thalamus, specifically the anterior thalamic nuclei (ATN), contains brain signals including that of head direction cells, which fire as a function of an animal's directional orientation in an environment. Recent work has suggested that this directional orientation information stemming from the ATN contributes to the generation of hippocampal and parahippocampal spatial representations, and may contribute to the establishment of unique spatial representations in radially oriented tasks such as the radial arm maze...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28264765/a-functional-connectivity-comparison-between-attention-deficit-hyperactivity-disorder-and-bipolar-disorder-in-medication-na%C3%A3-ve-adolescents-with-mood-fluctuation-and-attention-problems
#7
Young Don Son, Doug Hyun Han, Sun Mi Kim, Kyung Joon Min, Perry F Renshaw
In order to compare patterns of connectivity between affective and attention networks in adolescents with bipolar disorder (BD) and attention deficit hyperactivity disorder (ADHD), we investigated differences in resting state functional connectivity (RSFC) between these populations. Study participants were medication-naïve adolescents (aged 13-18 years) with BD (N=22) or ADHD (N=25) and age- and sex-matched healthy adolescents (healthy controls [HC]) (N=22). Forty-seven adolescents with mood fluctuation and attention problems showed increased functional correlation (FC) between two pairs of regions within the affective network (AFN), compared to 22 HC: the left orbitofrontal cortex (OFC) to the left thalamus and the left OFC to the right thalamus...
February 17, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28249642/preclinical-upar-targeted-multimodal-imaging-of-locoregional-oral-cancer
#8
M C Boonstra, P B A A Van Driel, S Keereweer, H A J M Prevoo, M A Stammes, V M Baart, C W G M Löwik, A P Mazar, C J H van de Velde, A L Vahrmeijer, C F M Sier
OBJECTIVES: Establishing adequate resection margins and lymphatic mapping are crucial for the prognosis of oral cancer patients. Novel targeted imaging modalities are needed, enabling pre- and intraoperative detection of tumour cells, in combination with improved post-surgical examination by the pathologist. The urokinase-receptor (uPAR) is overexpressed in head and neck cancer, where it is associated with tumour progression and metastasis. MATERIAL AND METHODS: To determine suitability of uPAR for molecular imaging of oral cancer surgery, human head and neck tumours were sectioned and stained for uPAR to evaluate the expression pattern compared to normal mucosa...
March 2017: Oral Oncology
https://www.readbyqxmd.com/read/28249550/amelioration-of-penetrating-ballistic-like-brain-injury-induced-cognitive-deficits-after-neuronal-differentiation-of-transplanted-human-neural-stem-cells
#9
Markus S Spurlock, Aminul Islam Ahmed, Karla N Rivera, Shoji Yokobori, Stephanie W Lee, Pingdewinde N Sam, Deborah A Shear, Michael P Hefferan, Thomas G Hazel, Karl K Johe, Shyam Gajavelli, Frank C Tortella, Ross Bullock
Penetrating traumatic brain injury (PTBI) is one of the major cause of death and disability worldwide. Previous studies in penetrating ballistic-like brain injury (PBBI), a PTBI rat model revealed widespread peri-lesional neurodegeneration, similar to that seen in humans following gunshot wound to head, which is unmitigated by any available therapies to date. Therefore, we evaluated human neural stem cell (hNSC) engraftment to putatively exploit the potential of cell therapy that has been seen in other central nervous system injury models...
March 1, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28240739/tubular-peroxiredoxin-3-as-a-predictor-of-renal-recovery-from-acute-tubular-necrosis-in-patients-with-chronic-kidney-disease
#10
Chia-Lin Wu, Tzu-Cheng Su, Chia-Chu Chang, Chew-Teng Kor, Chung-Ho Chang, Tao-Hsiang Yang, Ping-Fang Chiu, Der-Cherng Tarng
Peroxiredoxin 3 (PRX3) is a mitochondrial antioxidant that regulates apoptosis in various cancers. However, whether tubular PRX3 predicts recovery of renal function following acute kidney injury (AKI) remains unknown. This retrospective cohort study included 54 hospitalized patients who had AKI with biopsy-proven acute tubular necrosis (ATN). The study endpoint was renal function recovery within 6 months. Of the 54 enrolled patients, 25 (46.3%) had pre-existing chronic kidney disease (CKD) and 33 (61%) recovered renal function...
February 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28182674/evaluation-of-altitude-appropriate-reference-ranges-for-neutrophils-in-diagnosis-of-sepsis-in-very-low-birth-weight-infants-a-multicenter-retrospective-study
#11
Jianhui Wang, Jialin Yu, Juan Fan, Yu He, Wenhui Dong, Zhengli Wang
BACKGROUND: The circulating neutrophil count was commonly believed to be influenced by altitude. At present, neutrophil reference ranges (RRs) for very low birth weight (VLBW) neonates are only available from the sea level and from high altitude. This study aimed to construct RRs for neutrophils in VLBW infants in an intermediate-altitude area and assess its usefulness in evaluation for sepsis. METHODS: This was a multicenter retrospective study of 2173 VLBW infants admitted to 20 hospitals in Chongqing in southwest of China with altitude from 1000 to 2600 feet...
2017: PloS One
https://www.readbyqxmd.com/read/28149814/an-unusual-finding-of-the-auriculotemporal-nerve-possible-risk-factor-during-preauricular-skin-incisions
#12
Joe Iwanaga, Samuel L Bobek, Christian Fisahn, Ken Nakamura, Yoshihiro Miyazono, R Shane Tubbs
The auriculotemporal nerve (ATN) is a branch of the mandibular nerve and has been implicated for some migraines and its role in Frey's syndrome is well known. An adult cadaver was found to have a duplicated ATN. The anterior trunk ascended as the superficial temporal artery and gave off the branches to the temporomandibular joint, parotid gland, external acoustic meatus and temporal region and communicated with a posterior trunk of the ATN. The posterior trunk ascended via the subcutaneous tissues 1 mm anterior to the auricle and gave off the branches to the anterior auricular region, temporal region and communicated with the anterior trunk...
December 2016: Gland Surgery
https://www.readbyqxmd.com/read/28120309/microbial-production-of-astilbin-a-bioactive-rhamnosylated-flavanonol-from-taxifolin
#13
Nguyen Huy Thuan, Sailesh Malla, Nguyen Thanh Trung, Dipesh Dhakal, Anaya Raj Pokhrel, Luan Luong Chu, Jae Kyung Sohng
Flavonoids are plant-based polyphenolic biomolecules with a wide range of biological activities. Glycosylated flavonoids have drawn special attention in the industries as it improves solubility, stability, and bioactivity. Herein, we report the production of astilbin (ATN) from taxifolin (TFN) in genetically-engineered Escherichia coli BL21(DE3). The exogenously supplied TFN was converted to ATN by 3-O-rhamnosylation utilizing the endogeneous TDP-L-rhamnose in presence of UDP-glycosyltransferase (ArGT3, Gene Bank accession number: At1g30530) from Arabidopsis thaliana...
February 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28043395/artesunate-tafenoquine-combination-therapy-promotes-clearance-and-abrogates-transmission-of-the-avian-malaria-parasite-plasmodium-gallinaceum
#14
Suchada Tasai, Tawee Saiwichai, Morakot Kaewthamasorn, Sonthaya Tiawsirisup, Prayute Buddhirakkul, Sirintip Chaichalotornkul, Sittiporn Pattaradilokrat
Clinical manifestations of malaria infection in vertebrate hosts arise from the multiplication of the asexual stage parasites in the blood, while the gametocytes are responsible for the transmission of the disease. Antimalarial drugs that target the blood stage parasites and transmissible gametocytes are rare, but are essentially needed for the effective control of malaria and for limiting the spread of resistance. Artemisinin and its derivatives are the current first-line antimalarials that are effective against the blood stage parasites and gametocytes, but resistance to artemisinin has now emerged and spread in various malaria endemic areas...
January 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28034388/evidence-appraisal-of-tita-atn-szychowski-jm-boggess-k-et%C3%A2-al-adjunctive-azithromycin-prophylaxis-for-cesarean-delivery-n-engl-j-med-2016-375-1231-1241
#15
https://www.readbyqxmd.com/read/28013112/urine-interleukin-18-and-lipocalin-2-are-biomarkers-of-acute-tubular-necrosis-in-patients-with-cirrhosis-a-systematic-review-and-meta-analysis
#16
Jeremy Puthumana, Xavier Ariza, Justin M Belcher, Isabel Graupera, Pere Ginès, Chirag R Parikh
BACKGROUND & AIMS: Acute kidney injury (AKI) is a common complication in patients with cirrhosis that increases mortality. The most common causes of AKI in these patients are prerenal azotemia, acute tubular necrosis (ATN), and hepatorenal syndrome; it is important to determine the etiology of AKI to select the proper treatment and predict patient outcome. Urine biomarkers could be used to differentiate between patients with ATN and functional causes of AKI. We performed a systemic review and meta-analysis of published studies to determine whether urine levels of interleukin (IL)18 and lipocalin 2 or neutrophil gelatinase-associated lipocalin (NGAL) are associated with the development of ATN in patients with cirrhosis...
December 21, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28005375/atn-161-peptide-functionalized-reversibly-crosslinked-polymersomes-mediate-targeted-doxorubicin-delivery-into-melanoma-bearing-c57bl-6-mice
#17
Ning Zhang, Yifeng Xia, Yan Zou, Weijing Yang, Jian Zhang, Zhiyuan Zhong, Fenghua Meng
PHSCN peptide (licensed as ATN-161) is an effective α5β1 integrin inhibitor that has advanced to phase II clinical trials to treat solid tumors. Here we developed ATN-161 functionalized self-crosslinkable and intracellularly decrosslinkable polymersomes (ATN/SCID-Ps) for highly efficient and targeted delivery of doxorubicin hydrochloride (DOX•HCl) into B16F10 melanoma-bearing C57BL/6 mice. ATN/SCID-Ps exhibited a high loading capacity of DOX•HCl. The size of DOX-loaded ATN/SCID-Ps (DOX-ATN/SCID-Ps) decreased from 150 to 88 nm with increasing ATN surface densities from 0 to 100% (mol/mol)...
December 22, 2016: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/27984192/the-mitochondrial-genome-of-the-lepidopteran-host-cadaver-thitarodes-sp-of-ophiocordyceps-sinensis-and-related-phylogenetic-analysis
#18
Xincong Kang, Yongquan Hu, Jiang Hu, Liqin Hu, Feng Wang, Dongbo Liu
To understand the phylogeny of the host insect (Thitarodes sp.) of the fungus Ophiocordyceps sinensis, we sequenced, annotated and characterized the complete mitochondrial (mt) genome of the host cadaver of a natural O. sinensis. Further, we compared the Thitarodes sp. mt genome with those of the other 7 sequenced Hepialidae and examined the phylogenetic relationships using a constructed Maximum Likelihood (ML) phylogenetic tree and mt genomic features (genetic distances and intergenic spacers). The mt genome is a circular molecule of 16,280bp in length with a high A+T content (81...
January 20, 2017: Gene
https://www.readbyqxmd.com/read/27974854/characterization-of-the-complete-mitochondrial-genome-of-leucoma-salicis-lepidoptera-lymantriidae-and-comparison-with-other-lepidopteran-insects
#19
Yu-Xuan Sun, Lei Wang, Guo-Qing Wei, Cen Qian, Li-Shang Dai, Yu Sun, Muhammad Nadeem Abbas, Bao-Jian Zhu, Chao-Liang Liu
The complete mitochondrial genome (mitogenome) of Leucoma salicis (Lepidoptera: Lymantriidae) was sequenced and annotated. It is a circular molecule of 15,334 bp, containing the 37 genes usually present in insect mitogenomes. All protein-coding genes (PCGs) are initiated by ATN codons, other than cox1, which is initiated by CGA. Three of the 13 PCGs had an incomplete termination codon, T or TA, while the others terminated with TAA. The relative synonymous codon usage of the 13 protein-coding genes (PCGs) was consistent with those of published lepidopteran sequences...
December 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27938477/effects-of-human-es-derived-neural-stem-cell-transplantation-and-kindling-in-a-rat-model-of-traumatic-brain-injury
#20
Stefania Beretta, Kelly Cunningham, Daniel Haus, Eric Gold, Harvey Perez, Luci López-Velázquez, Brian Cummings
Traumatic Brain Injury (TBI) is one of the leading causes of death and disability in the population worldwide, with a broad spectrum of symptoms and disabilities. Post-traumatic hyperexcitability is one of the most common neurological disorders that affect people after a head injury. A reliable animal model of post-traumatic hyperexcitability induced by TBI which allows one to test effective treatment strategies has yet to be developed. To address these issues, in the present study, we tested human ES-derived neural stem cell transplantation in an animal model of post-traumatic hyperexcitability in which the brain injury was produced in one hemisphere of immunodeficient athymic nude (ATN) rats by controlled cortical impact (CCI) and spontaneous seizures were produced by repeated electrical stimulation (kindling) in the contralateral hemisphere...
November 22, 2016: Cell Transplantation
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