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https://www.readbyqxmd.com/read/28043395/artesunate-tafenoquine-combination-therapy-promotes-clearance-and-abrogates-transmission-of-the-avian-malaria-parasite-plasmodium-gallinaceum
#1
Suchada Tasai, Tawee Saiwichai, Morakot Kaewthamasorn, Sonthaya Tiawsirisup, Prayute Buddhirakkul, Sirintip Chaichalotornkul, Sittiporn Pattaradilokrat
Clinical manifestations of malaria infection in vertebrate hosts arise from the multiplication of the asexual stage parasites in the blood, while the gametocytes are responsible for the transmission of the disease. Antimalarial drugs that target the blood stage parasites and transmissible gametocytes are rare, but are essentially needed for the effective control of malaria and for limiting the spread of resistance. Artemisinin and its derivatives are the current first-line antimalarials that are effective against the blood stage parasites and gametocytes, but resistance to artemisinin has now emerged and spread in various malaria endemic areas...
January 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28034388/evidence-appraisal-of-tita-atn-szychowski-jm-boggess-k-et%C3%A2-al-adjunctive-azithromycin-prophylaxis-for-cesarean-delivery-n-engl-j-med-2016-375-1231-1241
#2
https://www.readbyqxmd.com/read/28013112/urine-interleukin-18-and-lipocalin-2-are-biomarkers-of-acute-tubular-necrosis-in-patients-with-cirrhosis-a-systematic-review-and-meta-analysis
#3
Jeremy Puthumana, Xavier Ariza, Justin M Belcher, Isabel Graupera, Pere Ginès, Chirag R Parikh
BACKGROUND & AIMS: Acute kidney injury (AKI) is a common complication in patients with cirrhosis that increases mortality. The most common causes of AKI in these patients are prerenal azotemia, acute tubular necrosis (ATN), and hepatorenal syndrome; it is important to determine the etiology of AKI to select the proper treatment and predict patient outcome. Urine biomarkers could be used to differentiate between patients with ATN and functional causes of AKI. We performed a systemic review and meta-analysis of published studies to determine whether urine levels of interleukin 18 (IL18) and lipocalin 2 (LCN2 or NGAL) associate with development of ATN in patients with cirrhosis...
December 21, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28005375/atn-161-peptide-functionalized-reversibly-crosslinked-polymersomes-mediate-targeted-doxorubicin-delivery-into-melanoma-bearing-c57bl-6-mice
#4
Ning Zhang, Yifeng Xia, Yan Zou, Weijing Yang, Jian Zhang, Zhiyuan Zhong, Fenghua Meng
PHSCN peptide (licensed as ATN-161) is an effective α5β1 integrin inhibitor that has advanced to phase II clinical trials to treat solid tumors. Here we developed ATN-161 functionalized self-crosslinkable and intracellularly decrosslinkable polymersomes (ATN/SCID-Ps) for highly efficient and targeted delivery of doxorubicin hydrochloride (DOX•HCl) into B16F10 melanoma-bearing C57BL/6 mice. ATN/SCID-Ps exhibited a high loading capacity of DOX•HCl. The size of DOX-loaded ATN/SCID-Ps (DOX-ATN/SCID-Ps) decreased from 150 to 88 nm with increasing ATN surface densities from 0 to 100% (mol/mol)...
December 22, 2016: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/27984192/the-mitochondrial-genome-of-the-lepidopteran-host-cadaver-thitarodes-sp-of-ophiocordyceps-sinensis-and-related-phylogenetic-analysis
#5
Xincong Kang, Yongquan Hu, Jiang Hu, Liqin Hu, Feng Wang, Dongbo Liu
To understand the phylogeny of the host insect (Thitarodes sp.) of the fungus Ophiocordyceps sinensis, we sequenced, annotated and characterized the complete mitochondrial (mt) genome of the host cadaver of a natural O. sinensis. Further, we compared the Thitarodes sp. mt genome with those of the other 7 sequenced Hepialidae and examined the phylogenetic relationships using a constructed Maximum Likelihood (ML) phylogenetic tree and mt genomic features (genetic distances and intergenic spacers). The mt genome is a circular molecule of 16,280bp in length with a high A+T content (81...
October 27, 2016: Gene
https://www.readbyqxmd.com/read/27974854/characterization-of-the-complete-mitochondrial-genome-of-leucoma-salicis-lepidoptera-lymantriidae-and-comparison-with-other-lepidopteran-insects
#6
Yu-Xuan Sun, Lei Wang, Guo-Qing Wei, Cen Qian, Li-Shang Dai, Yu Sun, Muhammad Nadeem Abbas, Bao-Jian Zhu, Chao-Liang Liu
The complete mitochondrial genome (mitogenome) of Leucoma salicis (Lepidoptera: Lymantriidae) was sequenced and annotated. It is a circular molecule of 15,334 bp, containing the 37 genes usually present in insect mitogenomes. All protein-coding genes (PCGs) are initiated by ATN codons, other than cox1, which is initiated by CGA. Three of the 13 PCGs had an incomplete termination codon, T or TA, while the others terminated with TAA. The relative synonymous codon usage of the 13 protein-coding genes (PCGs) was consistent with those of published lepidopteran sequences...
December 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27938477/effects-of-human-es-derived-neural-stem-cell-transplantation-and-kindling-in-a-rat-model-of-traumatic-brain-injury
#7
Stefania Beretta, Kelly Cunningham, Daniel Haus, Eric Gold, Harvey Perez, Luci López-Velázquez, Brian Cummings
Traumatic Brain Injury (TBI) is one of the leading causes of death and disability in the population worldwide, with a broad spectrum of symptoms and disabilities. Post-traumatic hyperexcitability is one of the most common neurological disorders that affect people after a head injury. A reliable animal model of post-traumatic hyperexcitability induced by TBI which allows one to test effective treatment strategies has yet to be developed. To address these issues, in the present study, we tested human ES-derived neural stem cell transplantation in an animal model of post-traumatic hyperexcitability in which the brain injury was produced in one hemisphere of immunodeficient athymic nude (ATN) rats by controlled cortical impact (CCI) and spontaneous seizures were produced by repeated electrical stimulation (kindling) in the contralateral hemisphere...
22, 2016: Cell Transplantation
https://www.readbyqxmd.com/read/27920815/early-onset-acute-tubular-necrosis-following-single-infusion-of-zoledronate
#8
Ralph Yachoui
Zoledronate is a highly potent bisphosphonate widely used in the treatment of postmenopausal osteoporosis. We report the first occurrence of toxic acute tubular necrosis (ATN) following treatment with zoledronate in a patient with osteoporosis. A 63-year-old Caucasian female with rheumatoid arthritis on anti-immune agents received a single dose of zoledronic acid (reclast) for worsening osteoporosis. Twelve days later, she developed renal failure with a rise in serum creatinine from a baseline level of 1.1 mg/dL to 5...
May 2016: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/27919705/the-complete-mitochondrial-genome-of-thitarodes-sejilaensis-lepidoptera-hepialidae-a-host-insect-of-ophiocordyceps-sinensis-and-its-implication-in-taxonomic-revision-of-hepialus-adopted-in-china
#9
Zhiwen Zou, Qiang Min, Shiyu Cheng, Tianrong Xin, Bin Xia
The mitochondrial genome is widely used for phylogenetic analyses and evolutionary biology. The complete mitochondrial genome of Thitarodes sejilaensis (Lepidoptera: Hepialidae) was sequenced and analyzed in this study. This mitogenome is a typical circular molecule of 15,290bp, with the gene content, orientation and order identical to other insects in the family Hepialidae. The genome nucleotide composition is heavily biased towards As and Ts, accounting for 80.87% of total nucleotide content. The major strand shows a positive AT-skew and negative GC-skew...
February 15, 2017: Gene
https://www.readbyqxmd.com/read/27919615/anatomical-study-of-the-superficial-temporal-branches-of-the-auriculotemporal-nerve-application-to-surgery-and-other-invasive-treatments-to-the-temporal-region
#10
Joe Iwanaga, Koichi Watanabe, Tsuyoshi Saga, Christian Fisahn, Rod J Oskouian, R Shane Tubbs
BACKGROUND AND AIM: The auriculotemporal nerve (ATN) is one of the branches of the mandibular division of the trigeminal nerve, which gives rise to many branches to the retromandibular and temporal regions. Of these, the superficial temporal branch can occasionally be the cause of migraine headaches and auriculotemporal neuralgia. The purpose of this study was to elucidate the anatomy of the superficial temporal branch, which has never been described in detail. METHODS: A total of 14 sides of cadaveric heads were used for this study...
November 11, 2016: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/27894945/successful-treatment-of-refractory-status-epilepticus-using-anterior-thalamic-nuclei-deep-brain-stimulation
#11
Ching-Yi Lee, Siew-Na Lim, Tony Wu, Shih-Tseng Lee
BACKGROUND: Refractory status epilepticus(RSE) is considered a medical emergency in neurology and is related to a high mortality rate. We report a successfully treated case of RSE using deep brain stimulation (DBS) at the anterior thalamic nuclei (ATN). METHOD: Report concerning the resolution of RSE after DBS of the ATN in a 17-year-old woman RESULT: This patient developed RSE due to progressive seizure activity. RSE with generalized tonic-clonic seizures was noted two weeks prior to admission...
November 25, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27871857/bmi-1-plays-a-critical-role-in-the-protection-from-acute-tubular-necrosis-by-mobilizing-renal-stem-progenitor-cells
#12
Xianhui Lv, Zhenzhen Yu, Chunfeng Xie, Xiuliang Dai, Qing Li, Dengshun Miao, Jianliang Jin
The regeneration of injured tubular cell occurs primarily from intrinsic renal stem/progenitor cells (RSCs) labeled with CD24 and CD133 after acute tubular necrosis (ATN). Bmi-1 plays a crucial role in regulating self-renewal, differentiation and aging of multiple adult stem cells and progenitor cells. Bmi-1 was rapidly elevated in the induction of adult kidney regeneration by renal injury. To determine whether Bmi-1 maintained mobilization of RSCs in the protection from ATN, glycerol-rhabdomyolysis-induced ATN were performed in wild type (WT) and Bmi-1-deficient (Bmi-1(-/-)) mice...
January 22, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27861147/arctigenin-inhibits-stat3-and-exhibits-anticancer-potential-in-human-triple-negative-breast-cancer-therapy
#13
Tingting Feng, Wei Cao, Wanxiang Shen, Liang Zhang, Xinsheng Gu, Yang Guo, Hsiang-I Tsai, Xuewen Liu, Jian Li, Jingxuan Zhang, Shan Li, Fuyun Wu, Ying Liu
Triple-negative breast cancers (TNBCs) are the most aggressive and hard-to-treat breast tumors with poor prognosis, and exploration for novel therapeutic drugs is impending. Arctigenin (Atn), a bioactive lignan isolated from seeds of Arctium lappa L, has been reported to inhibit many cancer types; however, the effect of Atn on TNBC remains unclear. In this study, we demonstrated that Atn decreased proliferation, and induced apoptosis in TNBC cells. Furthermore, we explored the underlying mechanism of Atn inhibition on TNBC cells...
November 16, 2016: Oncotarget
https://www.readbyqxmd.com/read/27830427/factors-associated-with-self-injurious-behaviors-in-children-with-autism-spectrum-disorder-findings-from-two-large-national-samples
#14
G N Soke, S A Rosenberg, R F Hamman, T Fingerlin, C R Rosenberg, L Carpenter, L C Lee, E Giarelli, L D Wiggins, M S Durkin, A Reynolds, C DiGuiseppi
In this study, we explored potential associations among self-injurious behaviors (SIB) and a diverse group of protective and risk factors in children with autism spectrum disorder from two databases: Autism and Developmental Disabilities Monitoring (ADDM) Network and the Autism Speaks-Autism Treatment Network (AS-ATN). The presence of SIB was determined from children's records in ADDM and a parent questionnaire in AS-ATN. We used multiple imputation to account for missing data and a non-linear mixed model with site as a random effect to test for associations...
November 9, 2016: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/27822711/the-complete-mitogenome-of-a-jumping-spider-carrhotus-xanthogramma-araneae-salticidae-and-comparative-analysis-in-four-salticid-mitogenomes
#15
Wen-Yuan Fang, Zheng-Liang Wang, Chao Li, Xiao-Qing Yang, Xiao-Ping Yu
The complete mitogenome of the jumping spider Carrhotus xanthogramma was determined and comparative analysis among four salticid mitogenomes was conducted. The circular genome is 14,563 bp in size and contains a complete set of genes that usually present in the metazoa. All of the 13 protein-coding genes begin with a typical ATN codon and stop with the canonical stop codons, except for ND4 and ND4L genes with an incomplete stop codon T. All of the tRNAs cannot be formed the fully paired acceptor stems and seven out of them cannot be folded into the typical cloverleaf-shaped secondary structures...
December 2016: Genetica
https://www.readbyqxmd.com/read/27809280/role-of-oxidative-stress-in-drug-induced-kidney-injury
#16
REVIEW
Keiko Hosohata
The kidney plays a primary role in maintaining homeostasis and detoxification of numerous hydrophilic xenobiotics as well as endogenous compounds. Because the kidney is exposed to a larger proportion and higher concentration of drugs and toxins than other organs through the secretion of ionic drugs by tubular organic ion transporters across the luminal membranes of renal tubular epithelial cells, and through the reabsorption of filtered toxins into the lumen of the tubule, these cells are at greater risk for injury...
November 1, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27788506/overexpression-of-intrarenal-renin-angiotensin-system-in-human-acute-tubular-necrosis
#17
Wei Cao, Lingwei Jin, Zhanmei Zhou, Manqiu Yang, Chunyi Wu, Liling Wu, Shuang Cui
BACKGROUND/AIMS: Acute tubular necrosis (ATN), a leading cause of acute kidney injury (AKI), is associated with decreased survival and increased progression of chronic kidney disease. A barrier to improving the clinical outcomes is the incomplete understanding of the pathogenesis of AKI. Our objective is to test the hypothesis that intrarenal renin-angiotensin system (RAS) is overexpressed in patients with ATN and could be an indicator of ATN severity. METHODS: A transversal study was conducted in patients with biopsy-proven ATN...
2016: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/27785593/communication-deficits-and-the-motor-system-exploring-patterns-of-associations-in-autism-spectrum-disorder-asd
#18
M Mody, A M Shui, L A Nowinski, S B Golas, C Ferrone, J A O'Rourke, C J McDougle
Many children with autism spectrum disorder (ASD) have notable difficulties in motor, speech and language domains. The connection between motor skills (oral-motor, manual-motor) and speech and language deficits reported in other developmental disorders raises important questions about a potential relationship between motor skills and speech-language deficits in ASD. To this end, we examined data from children with ASD (n = 1781), 2-17 years of age, enrolled in the Autism Speaks-Autism Treatment Network (AS-ATN) registry who completed a multidisciplinary evaluation that included diagnostic, physical, cognitive and behavioral assessments as part of a routine standard of care protocol...
October 26, 2016: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/27770241/the-complete-mitochondrial-genome-of-trabala-vishnou-guttata-lepidoptera-lasiocampidae-and-the-related-phylogenetic-analyses
#19
Liuyu Wu, Xiao Xiong, Xuming Wang, Tianrong Xin, Jing Wang, Zhiwen Zou, Bin Xia
The bluish yellow lappet moth, Trabala vishnou guttata is an extraordinarily important pest in China. The complete mitochondrial genome is sequenced and determined firstly, which is based on traditional PCR amplification and primer walking methods with a length of 15,281 bp, including 13 protein-coding (PCG) genes, 22 transfer RNA (rRNA) genes, two ribosomal RNA (tRNA) genes, and an A + T-rich region. The gene order and orientation of the T. vishnou guttata mitogenome were identical to the other sequenced Lasiocampidae species...
December 2016: Genetica
https://www.readbyqxmd.com/read/27767191/the-first-complete-mitochondrial-genome-for-the-subfamily-limacodidae-and-implications-for-the-higher-phylogeny-of-lepidoptera
#20
Qiu-Ning Liu, Zhao-Zhe Xin, Dan-Dan Bian, Xin-Yue Chai, Chun-Lin Zhou, Bo-Ping Tang
The mitochondrial genome (mitogenome) provides important information for understanding molecular evolution and phylogeny. To determine the systematic status of the family Limacodidae within Lepidoptera, we infer a phylogenetic hypothesis based on the complete mitogenome of Monema flavescens (Lepidoptera: Limacodidae). The mitogenome of M. flavescens is 15,396 base pairs (bp), and includes 13 protein-coding genes (PCGs), two ribosomal RNA (rRNA) genes, 22 transfer RNA (tRNA) genes, and a control region (CR)...
October 21, 2016: Scientific Reports
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