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https://www.readbyqxmd.com/read/29045706/kidney-injury-molecule-1-staining-in-renal-allograft-biopsies-10-days-after-transplantation-is-inversely-correlated-with-functioning-proximal-tubular-epithelial-cells
#1
Jonna R Bank, Pieter van der Pol, Dianne Vreeken, Catherine Monge-Chaubo, Ingeborg M Bajema, Nicole Schlagwein, Daniëlle J van Gijlswijk, Sandra W van der Kooij, Marlies E J Reinders, Johan W de Fijter, Cees van Kooten
Background: Kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) are promising biomarkers for monitoring delayed graft function (DGF) after kidney transplantation. Here we investigated localization and distribution of KIM-1 and NGAL staining in renal allograft biopsies and studied their association with histological features, functional DGF (fDGF) and the tubular function slope (TFS), a functioning proximal tubular epithelial cell (PTEC) marker. Methods: Day 10 protocol biopsies of 64 donation after circulatory death recipients were stained for KIM-1 and NGAL and the positive area was quantified using ImageJ software...
October 16, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29040867/long-term-follow-up-of-anterior-thalamic-deep-brain-stimulation-in-epilepsy-a-11-year-single-center-experience
#2
Seong Hoon Kim, Sung Chul Lim, Jiyeon Kim, Byung-Chul Son, Kyung Jin Lee, Young-Min Shon
PURPOSE: Anterior thalamic deep brain stimulation (ATN DBS) is an emerging, effective treatment for patients with drug-resistant epilepsy, but long-term results on its efficacy and safety are lacking. To evaluate the long-term efficacy and safety of ATN DBS treatment, as well as predictors of its success, in patients with drug-refractory epilepsy (DRE). METHOD: We retrospectively studied clinical outcomes in 29 consecutive refractory epilepsy patients treated by a single DBS team (two neurosurgeons, four neurologists) over an 11-year period, for whom follow-up was performed for up to 137 months (mean, 74...
October 14, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29023314/renal-dysfunction-and-cirrhosis
#3
François Durand, Jody C Olson, Mitra K Nadim
PURPOSE OF REVIEW: Hepatorenal syndrome (HRS) does not represent the predominant phenotype of acute kidney injury (AKI) in cirrhosis. Early recognition of HRS helps initiate appropriate therapy. The aims of this review are to present redefinition of AKI, to list new biomarkers, to report recent data on vasopressors in HRS and to propose criteria for simultaneous liver and kidney transplantation (SLKT). RECENT FINDINGS: Urine output, which was not part of the definition of AKI might be reconsidered as it has an independent prognostic value...
October 11, 2017: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/29021958/complete-mitochondrial-genome-sequence-of-fruit-piercing-moth-eudocima-phalonia-linnaeus-1763-lepidoptera-noctuoidea
#4
Kuppusamy Sivasankaran, Pratheesh Mathew, Sekar Anand, Stanislaus Antony Ceasar, Soosaimanikam Mariapackiam, Savarimuthu Ignacimuthu
The complete mitochondrial genome of the fruit piercing moth Eudocima phalonia (Linnaeus, 1763) (Lepidoptera: Noctuoidea) was sequenced and characterized (Genbank Accession No: KY196412). The complete mitogenome is a circular molecule of 15,575 bp length, consisting of 13 protein-coding genes (PCGs), two ribosomal RNA genes (rrnS and rrnL), 22 transfer RNA (tRNA) genes and an A + T-rich region (D-loop). The nucleotide composition of the genome is highly A + T biased, accounting for 80.67% of nucleotides...
December 2017: Genomics Data
https://www.readbyqxmd.com/read/29020329/vitamin-d3-supplementation-increases-spine-bone-mineral-density-in-adolescents-and-young-adults-with-hiv-infection-being-treated-with-tenofovir-disoproxil-fumarate-a-randomized-placebo-controlled-trial
#5
Peter L Havens, Charles B Stephensen, Marta D Van Loan, Gertrud U Schuster, Leslie R Woodhouse, Patricia M Flynn, Catherine M Gordon, Cynthia G Pan, Brandy Rutledge, D Robert Harris, Georgine Price, Alyne Baker, William A Meyer, Craig M Wilson, Rohan Hazra, Bill G Kapogiannis, Kathleen Mulligan
Background: Tenofovir disoproxil fumarate (TDF) decreases bone mineral density (BMD). We hypothesized vitamin D3 (VITD3) would increase BMD in youth receiving TDF. Methods: Randomized double-blind placebo-controlled trial of directly observed VITD3 vs. placebo every 4 weeks for 48 weeks in youth ages 16-24 years with HIV, viral load <200 copies/mL, taking TDF-containing combination antiretroviral therapy (TDF-cART) for ≥180 days. Participants (N=214) received a daily multivitamin containing VITD3 400 IU and calcium 162 mg, plus monthly randomized VITD3 50,000 IU (N=109) or placebo (N=105)...
August 21, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29020194/comparison-of-measures-of-adherence-to-hiv-preexposure-prophylaxis-among-adolescent-and-young-men-who-have-sex-with-men-in-the-united-states
#6
Catherine A Koss, Sybil G Hosek, Peter Bacchetti, Peter L Anderson, Albert Y Liu, Howard Horng, Leslie Z Benet, Karen Kuncze, Alexander Louie, Parya Saberi, Craig M Wilson, Monica Gandhi
Background: Young men who have sex with men (MSM) are disproportionately impacted by HIV. Preexposure prophylaxis (PrEP) could reduce HIV acquisition among youth, but sub-optimal adherence threatens effectiveness. Optimal metrics of PrEP adherence among adolescents have not been defined. Methods: The ATN 110 and 113 studies provided daily oral PrEP with tenofovir (TFV) disoproxil fumarate/emtricitabine over 48 weeks to a diverse population of MSM (15-22 years). Self-reported adherence was assessed and PrEP drug concentrations measured from hair and dried blood spot (DBS) samples; 23% of participants received Wisepill electronic monitoring devices...
August 24, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28991884/hiv-continuum-of-care-for-youth-in-the-united-states
#7
Michelle A Lally, Jacob J van den Berg, Andrew O Westfall, Bret J Rudy, Sybil G Hosek, J Dennis Fortenberry, Dina Monte, Mary R Tanney, Elizabeth J McFarland, Jiahong Xu, Bill G Kapogiannis, Craig M Wilson
BACKGROUND: Beneficial HIV treatment outcomes require success at multiple steps along the HIV Continuum of Care. Youth living with HIV are a key population, and sites in the Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) are known for modeling optimum HIV adolescent care. METHODS: A longitudinal cohort study conducted at 14 network sites across the United States assessed how the later steps of the Continuum of Care were achieved among youth: engagement, treatment and viral load suppression...
October 4, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28978740/c-elegans-sorb-1-localizes-to-integrin-adhesion-sites-and-is-required-for-organization-of-sarcomeres-and-mitochondria-in-myocytes
#8
Timothy Loveless, Hiroshi Qadota, Guy M Benian, Jeff Hardin
We have identified and characterized sorb-1, the only Sorbin and SH3 domain-containing protein family member in C. elegans SORB-1 is strongly localized to integrin adhesion complexes in larvae and adults, including adhesion plaques and dense bodies (Z-disks) of striated muscles and attachment plaques of smooth muscles. SORB-1 is recruited to the actin-binding, membrane-distal regions of dense bodies via its C-terminal SH3 domains in an ATN-1(α-actinin)- and ALP-1(ALP/Enigma)-dependent manner, where it contributes to the organization of sarcomeres...
October 4, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28975359/urine-metabolomics-insight-into-acute-kidney-injury-point-to-oxidative-stress-disruptions-in-energy-generation-and-h2s-availability
#9
Marta Martin-Lorenzo, Laura Gonzalez-Calero, Angeles Ramos-Barron, Maria D Sanchez-Niño, Carlos Gomez-Alamillo, Juan Manuel García-Segura, Alberto Ortiz, Manuel Arias, Fernando Vivanco, Gloria Alvarez-Llamas
Acute kidney injury (AKI) is one of the main complications in acute care medicine and a risk factor for chronic kidney disease (CKD). AKI incidence has increased; however, its diagnosis has limitations and physiopathological mechanisms are underexplored. We investigated urine samples, aiming to identify major metabolite changes during human AKI evolution. Metabolic signatures found were further explored for a potential link to severity of injury. Twenty-four control subjects and 38 hospitalized patients with AKI were recruited and urine samples were collected at the time of diagnosis, during follow-up and at discharge...
October 4, 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/28971634/bone-age-assessments-by-quantitative-ultrasound-sonicbone-and-hand-x-ray-based-methods-are-comparable
#10
Marianna Rachmiel, Larisa Naugolni, Kineret Mazor-Aronovitch, Nira Koren-Morag, Tzvi Bistritzer
BACKGROUND: Bone maturation is currently assessed by subjective and automated radiography. OBJECTIVES: To evaluate the concordance and reproducibility of a quantitative ultrasound (QUS) based device versus X-ray based methods. METHODS: The study population comprised 150 children, 76 males, 4-17 years of age. X-ray scans were evaluated according to wrist, carpal and phalanx areas for bone age. QUS was performed by the the BAUS™ device (SonicBone, Rishon Lezion, Israel), using speed-of-sound (SOS) and distance attenuation factor (ATN) in similar areas...
September 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28970820/identification-of-novel-long-non-coding-and-circular-rnas-in-human-papillomavirus-mediated-cervical-cancer
#11
Hongbo Wang, Yingchao Zhao, Mingyue Chen, Jie Cui
Cervical cancer is the third most common cancer worldwide and the fourth leading cause of cancer-associated mortality in women. Accumulating evidence indicates that long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) may play key roles in the carcinogenesis of different cancers; however, little is known about the mechanisms of lncRNAs and circRNAs in the progression and metastasis of cervical cancer. In this study, we explored the expression profiles of lncRNAs, circRNAs, miRNAs, and mRNAs in HPV16 (human papillomavirus genotype 16) mediated cervical squamous cell carcinoma and matched adjacent non-tumor (ATN) tissues from three patients with high-throughput RNA sequencing (RNA-seq)...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28962847/complete-sequence-and-characterization-of-the-ectropis-oblique-mitochondrial-genome-and-its-phylogenetic-implications
#12
Li-Shang Dai, Saima Kausar, Muhammad Nadeem Abbas, Tian-Tian Wang
In the present study, we sequenced the entire mitochondrial genome (mitogenome) of Ectropis oblique using PCR amplification and sequencing methods The entire mitogenome is 15,356bp long, including 13 protein coding genes, 22 transfer RNA (tRNA) genes, two ribosomal RNA (rRNA) genes and A+T rich element. The base composition and gene arrangement are identical to those of other lepidopterans. Of these 37 genes, twenty three are resided on heavy strand, while fourteen located on light strand. The newly sequenced mitogenome displayed a biased Adenine/thymine 84...
September 26, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28941213/adaptive-behavior-in-autism-minimal-clinically-important-differences-on-the-vineland-ii
#13
C H Chatham, K I Taylor, T Charman, X Liogier D'ardhuy, E Eule, A Fedele, A Y Hardan, E Loth, L Murtagh, M Del Valle Rubido, A San Jose Caceres, J Sevigny, L Sikich, L Snyder, J E Tillmann, P E Ventola, K L Walton-Bowen, P P Wang, T Willgoss, F Bolognani
Autism Spectrum Disorder (ASD) is associated with persistent impairments in adaptive abilities across multiple domains. These social, personal, and communicative impairments become increasingly pronounced with development, and are present regardless of IQ. The Vineland Adaptive Behavior Scales, Second Edition (Vineland-II) is the most commonly used instrument for quantifying these impairments, but minimal clinically important differences (MCIDs) on Vineland-II scores have not been rigorously established in ASD...
September 21, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28921913/high-resolution-imaging-of-muscle-attachment-structures-in-c-elegans
#14
Hiroshi Qadota, Yohei Matsunaga, Ken C Q Nguyen, Alexa Mattheyses, David H Hall, Guy M Benian
We used structured illumination microscopy (SIM) to obtain super-resolution images of muscle attachment structures in C. elegans striated muscle. SIM imaging of M-line components revealed two patterns: PAT-3 (β-integrin) and proteins that interact in a complex with the cytoplasmic tail of β-integrin and localize to the basal muscle cell membrane (UNC-112 (kindlin), PAT-4 (ILK), UNC-97 (PINCH), PAT-6 (α-parvin) and UNC-95), are found in discrete, angled segments with gaps. In contrast, proteins localized throughout the depth of the M-line (UNC-89 (obscurin) and UNC-98) are imaged as continuous lines...
September 16, 2017: Cytoskeleton
https://www.readbyqxmd.com/read/28921161/deep-brain-stimulation-for-refractory-temporal-lobe-epilepsy-a-systematic-review-and-meta-analysis-with-an-emphasis-on-alleviation-of-seizure-frequency-outcome
#15
Bowen Chang, Jiwen Xu
OBJECTIVE: Conflicting conclusions have been reported regarding predictors of deep brain stimulation (DBS) outcome in patients with refractory temporal lobe epilepsy (TLE). The main goal of this meta-analysis study was to identify possible predictors of remarkable seizure reduction (RSR). METHODS: We conducted a comprehensive search of English-language literature published since 1990 and indexed in PubMed, Embase, and the Cochrane Library that addressed seizure outcomes in patients who underwent DBS for refractory TLE...
September 18, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28918702/anterior-thalamic-nuclei-deep-brain-stimulation-reduces-disruption-of-the-blood-brain-barrier-albumin-extravasation-inflammation-and-apoptosis-in-kainic-acid-induced-epileptic-rats
#16
Ying-Chuan Chen, Guan-Yu Zhu, Xiu Wang, Lin Shi, Ting-Ting Du, De-Feng Liu, Yu-Ye Liu, Yin Jiang, Xin Zhang, Jian-Guo Zhang
Objective The therapeutic efficacy of anterior thalamic nuclei deep brain stimulation (ATN-DBS) against seizures has been largely accepted; however, the effects of ATN-DBS on disruption of the blood-brain barrier (BBB), albumin extravasation, inflammation and apoptosis still remain unclear. Methods Rats were distributed into four treatment groups: physiological saline (PS, N = 12), kainic acid (KA, N = 12), KA-sham-DBS (N = 12) and KA-DBS (N = 12). Seizures were monitored using video-electroencephalogram (EEG)...
September 18, 2017: Neurological Research
https://www.readbyqxmd.com/read/28913775/complete-mitochondrial-genome-of-taharana-fasciana-insecta-hemiptera-cicadellidae-and-comparison-with-other-cicadellidae-insects
#17
Jiajia Wang, Hu Li, Renhuai Dai
Here, we describe the first complete mitochondrial genome (mitogenome) sequence of the leafhopper Taharana fasciana (Coelidiinae). The mitogenome sequence contains 15,161 bp with an A + T content of 77.9%. It includes 13 protein-coding genes, two ribosomal RNA genes, 22 transfer RNA genes, and one non-coding (A + T-rich) region; in addition, a repeat region is also present (GenBank accession no. KY886913). These genes/regions are in the same order as in the inferred insect ancestral mitogenome. All protein-coding genes have ATN as the start codon, and TAA or single T as the stop codons, except the gene ND3, which ends with TAG...
September 14, 2017: Genetica
https://www.readbyqxmd.com/read/28873373/biomarkers-of-renal-injury-in-cirrhosis-association-with-acute-kidney-injury-and-recovery-after-liver-transplantation
#18
Ashwani K Singal, Bradford Jackson, Glauber B Pereira, Kirk B Russ, Paul Stephen Fitzmorris, Donny Kakati, Page Axley, Sujan Ravi, Toni Seay, Satish P Ramachandra Rao, Ravindra Mehta, Yong-Fang Kuo, Karan P Singh, Anupam Agarwal
BACKGROUND: To define urine or serum biomarkers in predicting renal function recovery after liver transplantation (LT). METHODS: Adults listed for LT (February 2011-July 2014) and with modified diet for renal disease-6 (MDRD-6) <60 mL/min provided urine/blood samples at baseline and serially until LT for biomarkers in serum (pg/mL) and urine (pg/mg creatinine). RESULTS: Of 271 LT listed patients (mean age 57 years, 63% males, median listing MELD 17...
September 2, 2017: Nephron
https://www.readbyqxmd.com/read/28812079/computational-evaluation-of-aluminophosphate-zeotypes-for-co2-n2-separation
#19
Michael Fischer
Zeolites and structurally related materials (zeotypes) have received considerable attention as potential adsorbents for selective carbon dioxide adsorption. Within this group, zeotypes with aluminophosphate composition (AlPOs) could be an interesting alternative to the more frequently studied aluminosilicate zeolites. So far, however, only a few AlPOs have been characterised experimentally in terms of their CO2 adsorption properties. In this study, force-field based grand-canonical Monte Carlo (GCMC) simulations were used to evaluate the potential of AlPOs for CO2/N2 separation, a binary mixture that constitutes a suitable model system for the removal of carbon dioxide from flue gases...
August 16, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28801674/a-new-scoring-model-for-the-prediction-of-mortality-in-patients-with-acute-kidney-injury
#20
Min Luo, Yuan Yang, Jun Xu, Wei Cheng, Xu-Wei Li, Mi-Mi Tang, Hong Liu, Fu-You Liu, Shao-Bin Duan
Currently, little information is available to stratify the risks and predict acute kidney injury (AKI)-associated death. In this present cross-sectional study, a novel scoring model was established to predict the probability of death within 90 days in patients with AKI diagnosis. For establishment of predictive scoring model, clinical data of 1169 hospitalized patients with AKI were retrospectively collected, and 731 patients of them as the first group were analyzed by the method of multivariate logistic regression analysis to create a scoring model and further predict patient death...
August 11, 2017: Scientific Reports
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