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Cardiac injury

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https://www.readbyqxmd.com/read/29224017/the-il-2-anti-il-2-complex-attenuates-cardiac-ischaemia-reperfusion-injury-through-expansion-of-regulatory-t-cells
#1
Junhui Xiao, Kunwu Yu, Ming Li, Chuanyin Xiong, Yuzhen Wei, Qiutang Zeng
BACKGROUND/AIMS: Regulatory T cells (Tregs) can suppress immunologic damage in myocardial ischaemia/reperfusion injury (MIRI), however, the isolation and ex vivo expansion of these cells for clinical application remains challenging. Here, we investigated whether the IL-2/anti-IL-2 complex (IL-2C), a mediator of Treg expansion, can attenuate MIRI in mice. METHODS: Myocardial I/R was surgically induced in male C57BL/6 mice, aged 8-10 weeks, that were randomly assigned to 1) sham group (Sham), 2) Phosphate Buffered Saline (PBS), 3) IL-2-anti-IL-2 Ab complex (IL-2C), or 4) sham group, 5) PBS, 6) IL-2C after MIRI, or 7) IL-2C, 8) IL-2C+anti-CD25 mAbs, or 9) IL-2C; 10) IL-2C+anti-TGF-β1 mAbs, 11) IL-2C+anti-IL-10 mAbs...
December 7, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29223955/high-density-lipoprotein-cholesterol-concentration-and-acute-kidney-injury-after-cardiac-surgery
#2
Loren E Smith, Derek K Smith, Jeffrey D Blume, MacRae F Linton, Frederic T Billings
BACKGROUND: Acute kidney injury (AKI) after cardiac surgery is associated with increased short- and long-term mortality. Inflammation, oxidative stress, and endothelial dysfunction and damage play important roles in the development of AKI. High-density lipoproteins (HDLs) have anti-inflammatory and antioxidant properties and improve endothelial function and repair. Statins enhance HDL's anti-inflammatory and antioxidant capacities. We hypothesized that a higher preoperative HDL cholesterol concentration is associated with decreased AKI after cardiac surgery and that perioperative statin exposure potentiates this association...
December 9, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29223603/factors-predicting-quality-of-life-and-societal-participation-after-survival-of-a-cardiac-arrest-a-prognostic-longitudinal-cohort-study
#3
Daan Verberne, Veronique Moulaert, Jeanine Verbunt, Caroline van Heugten
AIM: For those patients who suffer unfavourable outcome after survival of cardiac arrest, it is important to know whether this can be predicted at an early stage. Support can subsequently be provided. This study aimed to identify early prognostic factors of quality of life (QOL) and societal participation at one year post-cardiac arrest. METHODS: The design was a prospective longitudinal cohort study following cardiac arrest survivors up to one year. Prognostic personal, injury-related, function-related and subjective outcome factors were selected and entered into a hierarchical regression model to assess whether they were predictive of QOL and societal participation at one year post-cardiac arrest...
December 6, 2017: Resuscitation
https://www.readbyqxmd.com/read/29223601/early-coronary-angiography-and-percutaneous-coronary-intervention-are-associated-with-improved-outcomes-after-out-of-hospital-cardiac-arrest
#4
Jacob C Jentzer, Michael Scutella, Francis Pike, James Fitzgibbon, Nicholas M Krehel, Lindsay Kowalski, Clifton W Callaway, Jon C Rittenberger, Joshua C Reynolds, Gregory W Barsness, Cameron Dezfulian
AIM: Early coronary angiography (CAG) and percutaneous coronary intervention (PCI) are associated with better outcomes in subjects resuscitated from out-of-hospital cardiac arrest (OHCA). We sought to determine the relative contributions of early CAG and PCI to outcomes and adverse events after OHCA. METHODS: We analyzed 599 OHCA subjects from a prospective two-center registry. Hospital survival, functional outcomes and adverse events were compared between subjects undergoing early CAG (within 24hours) with or without PCI and subjects not undergoing early CAG...
December 6, 2017: Resuscitation
https://www.readbyqxmd.com/read/29223591/mild-hypothermia-protects-hippocampal-neurons-from-oxygen-glucose-deprivation-injury-through-inhibiting-caspase-3-activation
#5
Tianen Zhou, Hui Lin, Longyuan Jiang, Tao Yu, Chaotao Zeng, Juanhua Liu, Zhengfei Yang
Mild hypothermia (MH) is thought to be one of the most effective therapeutic methods to treat hypoxic-ischemic encephalopathy (HIE) after cardiac arrest (CA). However, its precise mechanisms remain unclear. In this research, hippocampal neurons were cultured and treated with mild hypothermia and Ac-DEVD-CHO after oxygen-glucose deprivation (OGD). The activity of caspase-3 was detected, in order to find the precise concentration of Ac-DEVD-CHO with the same protective role in OGD injury as MH treatment. Western blot and immunofluorescence staining were conducted to analyze the effects of MH and Ac-DEVD-CHO on the expressions of caspase-3, caspase-8, and PARP...
December 6, 2017: Cryobiology
https://www.readbyqxmd.com/read/29222138/application-of-large-scale-aptamer-based-proteomic-profiling-to-planned-myocardial-infarctions
#6
Jaison Jacob, Debby Ngo, Nancy Finkel, Rebecca Pitts, Scott Gleim, Mark D Benson, Michelle J Keyes, Laurie A Farrell, Thomas Morgan, Lori L Jennings, Robert Gerszten
Background -Emerging proteomic technologies using novel affinity-based reagents allow for efficient multiplexing with high sample throughput. To identify early biomarkers of myocardial injury, we recently applied an aptamer-based proteomic profiling platform that measures 1,129 proteins to samples from patients undergoing septal alcohol ablation for hypertrophic cardiomyopathy, a human model of "planned myocardial injury" (PMI). Here we examined the scalability of this approach using a markedly expanded platform to study a far broader range of human proteins in the context of myocardial injury...
December 8, 2017: Circulation
https://www.readbyqxmd.com/read/29222072/heparan-sulfate-potentiates-leukocyte-adhesion-on-cardiac-fibroblast-by-enhantcing-vcam-1-and-icam-1-expression
#7
Francisco Olivares-Silva, Rodolfo Landaeta, Pablo Aránguiz, Samir Bolivar, Claudio Humeres, Renatto Anfossi, Raúl Vivar, Pía Boza, Claudia Muñoz, Viviana Pardo-Jiménez, Concepción Peiró, Carlos F Sánchez-Ferrer, Guillermo Díaz-Araya
Cardiac fibroblasts (CF) act as sentinel cells responding to chemokines, cytokines and growth factors released in cardiac tissue in cardiac injury events, such as myocardial infarction (MI). Cardiac injury involves the release of various damage-associated molecular patterns (DAMPs) including heparan sulfate (HS), a constituent of the extracellular matrix (ECM), through the TLR4 receptor activation triggering a strong inflammatory response, inducing leukocytes recruitment. This latter cells are responsible of clearing cell debris and releasing cytokines that promote CF differentiation to myofibroblast (CMF), thus initiating scar formation...
December 5, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29221978/influence-of-6-hydroxyethyl-starch-130-0-4-versus-crystalloid-solution-on-structural-renal-damage-markers-after-coronary-artery-bypass-grafting-a-post-hoc-subgroup-analysis-of-a-prospective-trial
#8
Thomas Datzmann, Markus Hoenicka, Helmut Reinelt, Andreas Liebold, Hagen Gorki
OBJECTIVE: The restriction of hydroxyethyl starch (HES) has mandated changes in volume management based on data of critically ill patients. Reliable data of structural renal damage after HES treatment in cardiac surgical patients are lacking. The influence of 6% HES 130/0.4 was investigated in this study. DESIGN: An exploratory post hoc subgroup analysis of a prospective trial was performed. SETTING: The study was carried out at a university hospital...
May 25, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29221746/clinical-and-neuroimaging-characteristics-of-cerebral-sinovenous-thrombosis-in-neonates-undergoing-cardiac-surgery
#9
Nathalie H P Claessens, Selma O Algra, Nicolaas J G Jansen, Floris Groenendaal, Esther de Wit, Alexander A Wilbrink, Felix Haas, Antonius N J Schouten, Rutger A J Nievelstein, Manon J N L Benders, Linda S de Vries
OBJECTIVES: Neonates with congenital heart disease may have an increased risk of cerebral sinovenous thrombosis, but incidence rates are lacking. This study describes the clinical and neuroimaging characteristics of cerebral sinovenous thrombosis in neonates undergoing cardiac surgery. METHODS: Forty neonates (78% male) requiring neonatal univentricular or biventricular cardiac repair using cardiopulmonary bypass were included. All underwent preoperative (median postnatal day 7) and postoperative (median postoperative day 7) magnetic resonance imaging of the brain, including venography, to detect cerebral sinovenous thrombosis...
November 8, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29221605/significance-of-high-sensitivity-troponin-t-after-elective-external-direct-current-cardioversion-for-atrial-fibrillation-or-atrial-flutter
#10
Ronstan Lobo, Allan S Jaffe, Ciara Cahill, Ophelia Blake, Syed Abbas, Thomas B Meany, Terrence Hennessy, Thomas J Kiernan
External transthoracic direct current (DC) cardioversion is a commonly used method of terminating cardiac arrhythmias. Previous research has shown that DC cardioversion resulted in myocardial injury as evidenced by increased levels of cardiac troponin, even though only minimally. Many of these studies were based on the outdated monophasic defibrillators and older, less sensitive troponin assays. This study aimed to assess the effect of external transthoracic DC cardioversion on myocardial injury as measured by the change in the new high-sensitivity cardiac troponin T (hs-cTnT) using the more modern biphasic defibrillators...
October 19, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29221272/goal-directed-fluid-restriction-using-stroke-volume-variation-and-cardiac-index-during-one-lung-ventilation-a-randomized-controlled-trial
#11
Hui Xu, Shu-Hua Shu, Di Wang, Xiao-Qing Chai, Yan-Hu Xie, Wei-De Zhou
Background: Goal-directed therapy confers a strong prognosis in patients undergoing major cardiac or noncardiac surgery. The present study investigated whether intraoperative goal-directed fluid restriction (GDFR) using stroke volume variation (SVV) and cardiac index could improve oxygenation and postoperative outcome in patients undergoing one-lung ventilation (OLV). Methods: A Total of 168 patients scheduled for elective thoracoscopic lobectomy under OLV were randomized into the GDFR protocol (group G) or conventional fluid therapy groups (group C)...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221204/11%C3%AE-hsd1-inhibition-ameliorates-diabetes-induced-cardiomyocyte-hypertrophy-and-cardiac-fibrosis-through-modulation-of-egfr-activity
#12
Chunpeng Zou, Weixin Li, Yong Pan, Zia A Khan, Jieli Li, Xixi Wu, Yi Wang, Liancheng Deng, Guang Liang, Yunjie Zhao
11β-HSD1 has been recognized as a potential therapeutic target for type 2 diabetes. Recent studies have shown that hyperglycemia leads to activation of 11β-HSD1, increasing the intracellular glucocorticoid levels. Excess glucocorticoids may lead to the clinical manifestations of cardiac injury. Therefore, the aim of this study is to investigate whether 11β-HSD1 activation contributes to the development of diabetic cardiomyopathy. To investigate the role of 11β-HSD1, we administered a selective 11β-HSD1 inhibitor in type 1 and type 2 murine models of diabetes and in cultured cardiomyocytes...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29220757/association-between-postoperative-fluid-balance-and-acute-kidney-injury-in-patients-after-cardiac-surgery-a-retrospective-cohort-study
#13
Yanfei Shen, Weimin Zhang, Xuping Cheng, Manzhen Ying
PURPOSE: The present study aims to explore appropriate postoperative fluid management in patients after cardiac surgery. MATERIALS AND METHODS: Data were extracted from an online database. Associations between fluid balance (FB), fluid intake and mortality were investigated. RESULTS: Compared to zero FB (level 3), more negative FB (level 1, odds ratio (OR): 0.938, 95% CI: 0.631-1.394; level 2, OR: 0.921, 95% CI: 0.709-1.196) could not further decrease AKI incidence while positive FB was associated with higher AKI incidence (level 4, OR: 1...
December 1, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/29220696/cardioprotection-of-cape-ono2-against-myocardial-ischemia-reperfusion-induced-ros-generation-via-regulating-the-sirt1-enos-nf-%C3%AE%C2%BAb-pathway-in-vivo-and-in-vitro
#14
Dejuan Li, Xiaoling Wang, Qin Huang, Sai Li, You Zhou, Zhubo Li
Caffeic acid phenethyl ester (CAPE) could ameliorate myocardial ischemia/reperfusion injury (MIRI) by various mechanisms, but there hadn't been any reports on that CAPE could regulate silent information regulator 1 (SIRT1) and endothelial nitric oxide synthase (eNOS) to exert cardioprotective effect. The present study aimed to investigate the cardioprotective potential of caffeic acid o-nitro phenethyl ester (CAPE-oNO2) on MIRI and the possible mechanism based on the positive control of CAPE. The SD rats were subjected to left coronary artery ischemia /reperfusion (IR) and the H9c2 cell cultured in hypoxia/reoxygenation (HR) to induce the MIRI model...
November 29, 2017: Redox Biology
https://www.readbyqxmd.com/read/29219009/micrornas-as-potential-prognosticators-of-neurological-outcome-in-out-of-hospital-cardiac-arrest-patients
#15
Sarah S Gul, Karl Huesgen, Kevin K Wang, Joseph A Tyndall
Out-of-hospital cardiac arrest survival rates have increased due to advancement in resuscitative measures, yet approximately 90% of survivors ultimately die or have severe neurologic dysfunction caused by ischemic injury. Currently, there are few early prognostic indicators of which patients have possibility of meaningful recovery. This leads to uncertainty for families and clinicians, as well as aggressive, invasive and expensive treatments despite medical futility. Several biomarkers investigated in traumatic brain injury have shown prognostication potential in ischemic brain injury...
December 8, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29218410/cardioprotective-effect-of-thyroid-hormone-is-mediated-by-at2-receptor-and-involves-nitric-oxide-production-via-akt-activation-in-mice
#16
Ivson Bezerra da Silva, Dayane Aparecida Gomes, Natalia Alenina, Michael Bader, Robson Augusto Dos Santos, Maria Luiza M Barreto-Chaves
Studies have demonstrated that thyroid hormone (T3) can precondition the heart against ischaemic injury and improve post-ischaemic recovery. This study investigated whether the AT2 receptor (AT2R) is involved in cardioprotection and the potential molecular mechanism responsible for this effect. Hyperthyroidism was induced in male wild-type (WT) and AT2R knockout (KO) mice by administering daily intraperitoneal injections of T3 (7 μg/100 g body weight) for 14 days. The mouse hearts were harvested and perfused with a Krebs-Henseleit solution at a constant flow in a Langendorff set-up...
December 7, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/29218098/overexpression-of-microrna-145-protects-against-rat-myocardial-infarction-through-targeting-pdcd4
#17
Hao Xu, Heng Cao, Guoqing Zhu, Shaowen Liu, Hongli Li
Myocardial infarction (MI) is a common cardiovascular disease with high mortality. The aim of the present study was to determine the biological role of miR-145 in MI rats and hypoxia-injured cardiomyocytes and to elucidate the potential mechanism. MI rats were induced by left anterior descending artery (LAD) ligation. qRT-PCR and western blot analysis were performed to determine the mRNA and protein levels, respectively. Compared with sham group, miR-145 levels in MI group were significantly decreased. We observed that lentivirus-mediated overexpression of miR-145 significantly improves cardiac function, reduces infarcted tissue size and prevents post-infarction induced apoptosis in rats after MI...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29217634/anthracycline-cardiotoxicity-an-update-on-mechanisms-monitoring-and-prevention
#18
REVIEW
Peter A Henriksen
Anthracycline chemotherapy causes dose-related cardiomyocyte injury and death leading to left ventricular dysfunction. Clinical heart failure may ensue in up to 5% of high-risk patients. Improved cancer survival together with better awareness of the late effects of cardiotoxicity has led to growing recognition of the need for surveillance of anthracycline-treated cancer survivors with early intervention to treat or prevent heart failure. The main mechanism of anthracycline cardiotoxicity is now thought to be through inhibition of topoisomerase 2β resulting in activation of cell death pathways and inhibition of mitochondrial biogenesis...
December 7, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29217004/transapical-transcatheter-aortic-valve-replacement-is-associated-with-increased-cardiac-mortality-in-patients-with-left%C3%A2-ventricular-dysfunction-insights-from-the-partner-i-trial
#19
Sammy Elmariah, William F Fearon, Ignacio Inglessis, Gus J Vlahakes, Brian R Lindman, Maria C Alu, Aaron Crowley, Susheel Kodali, Martin B Leon, Lars Svensson, Philippe Pibarot, Rebecca T Hahn, Vinod H Thourani, Igor F Palacios, D Craig Miller, Pamela S Douglas, Jonathan J Passeri
OBJECTIVES: The authors sought to evaluate the impact of transapical (TA) transcatheter aortic valve replacement (TAVR) on mortality, left ventricular (LV) ejection fraction (LVEF) improvement, and functional recovery in patients with LV dysfunction. BACKGROUND: LV injury inherent to TA access for structural heart disease interventions may be particularly detrimental to the LV, functional recovery, and survival in patients with LV dysfunction. METHODS: The study included patients enrolled within the PARTNER I (Placement of Aortic Transcatheter Valves) trial that underwent transfemoral (TF) or TA TAVR...
December 11, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29216946/-diagnostic-significance-of-urinary-neutrophil-gelatin-enzyme-related-lipid-delivery-protein-and-kidney-injury-molecule-1-in-acute-kidney-injury-after-cardiac-operation-with-cardiopulmonary-bypass-operation-in-children
#20
Yupeng Wen, Zongxiao Li, Cheng Chang, Peng Zhang, Yang Lyu
OBJECTIVE: To investigate the diagnostic value of urinary neutrophil gelatin enzyme-related lipid delivery protein (NGAL) and kidney injury molecule-1 (KIM-1) in the acute kidney injury (AKI) after cardiopulmonary bypass (CPB) operation in children with non-cyanotic congenital heart disease (CHD). METHODS: A retrospective analysis was conducted. 200 CPB undergoing cardiac surgery in children with non-cyanotic CHD admitted to Tianjin Children's Hospital from June 2015 to May 2017 were enrolled...
December 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
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