keyword
MENU ▼
Read by QxMD icon Read
search

Colistin and S. Maltophilia

keyword
https://www.readbyqxmd.com/read/27552791/pulmonary-exacerbation-due-to-colistin-resistant-stenotrophomonas-maltophilia-in-a-bulgarian-cystic-fibrosis-patient
#1
Gergana P Stoyanova, Tanya V Strateva, Svetlana T Atanasova, Dimitrinka S Miteva, Vera E Papochieva, Penka I Perenovska
In patients with cystic fibrosis (CF) lung damage secondary to chronic infection is the main cause of death. Treatment of lung disease to reduce the impact of infection, inflammation and subsequent lung injury is therefore of major importance. As Pseudomonas aeruginosa is the dominant pathogen in CF patients it has been the major target of all treatment strategies, possible antibiotic regimens and recommendations for years. More sophisticated antibiotic therapies introduced over the last decades have helped to improve the prognosis in cystic fibrosis, but then new multidrug-resistant pathogens emerged...
April 2016: Folia Medica
https://www.readbyqxmd.com/read/27551008/successful-treatment-of-bloodstream-infection-due-to-metallo-%C3%AE-lactamase-producing-stenotrophomonas-maltophilia-in-a-renal-transplant-patient
#2
Maria F Mojica, Christopher P Ouellette, Amy Leber, M Brian Becknell, Monica I Ardura, Federico Perez, Masako Shimamura, Robert A Bonomo, Samuel L Aitken, Samuel A Shelburne
Stenotrophomonas maltophilia is an emerging multidrug-resistant (MDR) opportunistic pathogen for which new antibiotic options are urgently needed. We report our clinical experience treating a 19-year-old renal transplant recipient who developed prolonged bacteremia due to metallo-β-lactamase-producing S. maltophilia refractory to conventional treatment. The infection recurred despite a prolonged course of colistimethate sodium (colistin) but resolved with the use of a novel drug combination with clinical efficacy against the patient's S...
September 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27497135/prevalence-of-multidrug-resistant-bacteria-on-fresh-vegetables-collected-from-farmers-markets-in-connecticut
#3
Deepti Prasad Karumathil, Hsin-Bai Yin, Anup Kollanoor-Johny, Kumar Venkitanarayanan
This study determined the prevalence of multidrug-resistant (MDR) Acinetobacter baumannii on fresh vegetables collected from farmers' markets in Connecticut. One hundred samples each of fresh carrots, potatoes, and lettuce were sampled and streaked on selective media, namely Leeds Acinetobacter and MDR Acinetobacter agars. All morphologically different colonies from MDR Acinetobacter agar were identified by using Gram staining, biochemical tests, and PCR. In addition, susceptibility of the isolates to 10 antibiotics commonly used in humans, namely imipenem, ceftriaxone, cefepime, minocycline, erythromycin, colistin-sulfate, streptomycin, neomycin, doxycycline, and rifampin was determined by using an antibiotic disk diffusion assay...
August 2016: Journal of Food Protection
https://www.readbyqxmd.com/read/27112832/minocycline-activity-tested-against-acinetobacter-baumannii-complex-stenotrophomonas-maltophilia-and-burkholderia-cepacia-species-complex-isolates-from-a-global-surveillance-program-2013
#4
Robert K Flamm, Mariana Castanheira, Jennifer M Streit, Ronald N Jones
Clinical isolates of Acinetobacter baumannii complex (1312), Stenotrophomonas maltophilia (464), and Burkholderia cepacia species complex (30) were selected from medical centers in the United States (USA), Europe and the Mediterranean (EU-M) region, Latin America, and Asia Pacific. Only one isolate per infected patient episode was included and local identifications were confirmed by the monitoring laboratory. Susceptibility testing was performed at the monitoring laboratory using the reference broth microdilution method as described by Clinical and Laboratory Standards Institute (CLSI)...
July 2016: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/26999818/evaluation-of-trimethoprim-sulfamethoxazole-sxt-minocycline-tigecycline-moxifloxacin-and-ceftazidime-alone-and-in-combinations-for-sxt-susceptible-and-sxt-resistant-stenotrophomonas-maltophilia-by-in-vitro-time-kill-experiments
#5
Chuanqi Wei, Wentao Ni, Xuejiu Cai, Jin Zhao, Junchang Cui
BACKGROUND: The optimal therapy for infections caused by Stenotrophomonas maltophilia (S. maltophilia) has not yet been established. The objective of our study was to evaluate the efficacy of trimethoprim/sulfamethoxazole (SXT), minocycline, tigecycline, moxifloxacin, levofloxacin, ticarcillin-clavulanate, polymyxin E, chloramphenicol, and ceftazidime against clinical isolated S. maltophilia strains by susceptibility testing and carried out time-kill experiments in potential antimicrobials...
2016: PloS One
https://www.readbyqxmd.com/read/26551572/antibiotic-susceptibility-of-sulfamethoxazole-trimethoprim-resistant-stenotrophomonas-maltophilia-strains-isolated-at-a-tertiary-care-centre-in-hungary
#6
Emese Juhász, Júlia Pongrácz, Miklós Iván, Katalin Kristóf
Sulfamethoxazole-trimethoprim (SXT) is the drug-of-choice in Stenotrophomonas maltophilia caused infections. There has been an increase in resistance to SXT of S. maltophilia over recent years. In this study 30 S. maltophilia clinical isolates resistant to SXT were investigated. Antibiotic susceptibilities for ciprofloxacin, moxifloxacin, levofloxacin, doxycycline, tigecycline, ceftazidime, colistin and chloramphenicol were determined by broth microdilution method. None of the strains were susceptible to ciprofloxacin, tigecycline, ceftazidime or colistin...
September 2015: Acta Microbiologica et Immunologica Hungarica
https://www.readbyqxmd.com/read/25851069/increased-prevalence-and-resistance-of-important-pathogens-recovered-from-respiratory-specimens-of-cystic-fibrosis-patients-during-a-decade
#7
Lena Raidt, Evgeny A Idelevich, Angelika Dübbers, Peter Küster, Pavel Drevinek, Georg Peters, Barbara C Kahl
BACKGROUND: The study objective was to identify changes of prevalence and resistance of important pathogens in specimens of cystic fibrosis (CF) patients within a decade. METHODS: Samples of 94 patients, who attended 2 CF centers from 2001 to 2011 were retrospectively analyzed. RESULTS: Staphylococcus aureus was the most prevalent organism (74.5% in 2011) with an increase of methicillin-resistant S. aureus in patients (0% vs. 9.6%, n = 9)...
July 2015: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/25551459/infection-and-colonization-by-stenotrophomonas-maltophilia-antimicrobial-susceptibility-and-clinical-background-of-strains-isolated-at-a-tertiary-care-centre-in-hungary
#8
Emese Juhász, Gergely Krizsán, György Lengyel, Gábor Grósz, Júlia Pongrácz, Katalin Kristóf
BACKGROUND: Stenotrophomonas maltophilia is an important opportunistic, mainly nosocomial pathogen that emerged in the last decades worldwide. Due to its inherent extended antibiotic resistance, therapeutic options are strongly limited. New resistance mechanisms in S. maltophilia make antibiotic therapy even more difficult. The aim of our study was to investigate the antimicrobial resistance of S. maltophilia isolates collected in our laboratory and to reveal related clinical background...
2014: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/25390933/a-linkage-between-smeijk-efflux-pump-cell-envelope-integrity-and-%C3%AF-e-mediated-envelope-stress-response-in-stenotrophomonas-maltophilia
#9
Yi-Wei Huang, Rung-Shiuan Liou, Yi-Tsung Lin, Hsin-Hui Huang, Tsuey-Ching Yang
Resistance nodulation division (RND) efflux pumps, such as the SmeIJK pump of Stenotrophomonas maltophilia, are known to contribute to the multidrug resistance in Gram-negative bacteria. However, some RND pumps are constitutively expressed even though no antimicrobial stresses occur, implying that there should be some physical implications for these RND pumps. In this study, the role of SmeIJK in antimicrobials resistance, envelope integrity, and σE-mediated envelope stress response (ESR) of S. maltophilia was assessed...
2014: PloS One
https://www.readbyqxmd.com/read/25202682/infections-caused-by-stenotrophomonas-maltophilia-in-recipients-of-hematopoietic-stem-cell-transplantation
#10
REVIEW
Khalid Ahmed Al-Anazi, Asma M Al-Jasser
Stenotrophomonas maltophilia (S. maltophilia) is a globally emerging Gram-negative bacillus that is widely spread in environment and hospital equipment. Recently, the incidence of infections caused by this organism has increased, particularly in patients with hematological malignancy and in recipients of hematopoietic stem cell transplantation (HSCT) having neutropenia, mucositis, diarrhea, central venous catheters or graft versus host disease and receiving intensive cytotoxic chemotherapy, immunosuppressive therapy, or broad-spectrum antibiotics...
2014: Frontiers in Oncology
https://www.readbyqxmd.com/read/25134721/activity-of-the-type-i-signal-peptidase-inhibitor-md3-against-multidrug-resistant-gram-negative-bacteria-alone-and-in-combination-with-colistin
#11
Yoann Personne, Michael A Curtis, David W Wareham, Richard D Waite
OBJECTIVES: Effective treatment of Gram-negative bacterial infections is increasingly challenging due to the spread of multidrug-resistant strains and a lack of new antimicrobials in development. Bacterial type I signal peptidases (SPases) represent a highly conserved and essential target for inhibition by novel compounds. SPases are required for the effective processing of membrane translocated proteins involved in core functions related to metabolism, virulence and resistance. In this study we assessed the biochemical and functional activity of a novel synthetic inhibitor (MD3) of SPases against a wide range of Gram-negative pathogens...
December 2014: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/24781003/activity-of-colistin-in-combination-with-tigecycline-or-rifampicin-against-multidrug-resistant-stenotrophomonas-maltophilia
#12
J W Betts, L M Phee, N Woodford, D W Wareham
The antimicrobial treatment of Stenotrophomonas maltophilia infections is complicated by intrinsic multidrug resistance and a lack of reliable susceptibility data. We assessed the activity of colistin (COL), rifampicin (RIF) and tigecycline (TGC) alone and in combination using a range of in vitro susceptibility testing methodologies and a simple invertebrate model of S. maltophilia infection (Galleria mellonella). Synergy [fractional inhibitory concentration indices (FICIs) ≤0.5] between COL and either RIF or TGC was observed against 92 % and 88 % of 25 S...
September 2014: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/24690894/effects-of-green-tea-compound-epigallocatechin-3-gallate-against-stenotrophomonas-maltophilia-infection-and-biofilm
#13
Pedrina G Vidigal, Mathias Müsken, Katrin A Becker, Susanne Häussler, Jost Wingender, Eike Steinmann, Jan Kehrmann, Erich Gulbins, Jan Buer, Peter Michael Rath, Jörg Steinmann
We investigated the in vitro and in vivo activities of epigallocatechin-3-gallate (EGCg), a green tea component, against Stenotrophomonas maltophilia (Sm) isolates from cystic fibrosis (CF) patients. In vitro effects of EGCg and the antibiotic colistin (COL) on growth inhibition, survival, and also against young and mature biofilms of S. maltophilia were determined. Qualitative and quantitative changes on the biofilms were assessed by confocal laser scanning microscopy (CLSM). Further, in vivo effects of nebulized EGCg in C57BL/6 and Cftr mutant mice during acute Sm lung infection were evaluated...
2014: PloS One
https://www.readbyqxmd.com/read/24270139/emergence-of-unusual-nonfermenting-gram-negative-nosocomial-pathogens-in-a-saudi-hospital
#14
Ahmed Morad Asaad, Mohamed Said Zayed Al-Ayed, Mohamed Ansar Qureshi
This study aimed to determine the frequency of isolation and prevalence of drug resistance in nonfermenting Gram-negative bacilli (NFGNB) other than Pseudomonas aeruginosa and predisposing factors for the acquisition of nosocomial infections caused by these emerging pathogens in a Saudi tertiary care hospital. A total of 125 nonduplicating NFGNB nosocomial strains were isolated, of these, 68 (54.4%) were Acinetobacter baumannii, 26 (20.8%) Stenotrophomonas maltophilia, 14 (11.2%) Alcaligenes faecalis, 12 (9...
2013: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/23719852/evaluation-of-colistin-susceptibility-in-multidrug-resistant-clinical-isolates-from-cystic-fibrosis-france
#15
S Biswas, J-C Dubus, M Reynaud-Gaubert, N Stremler, J-M Rolain
The emergence of multidrug-resistant (MDR) bacteria in cystic fibrosis (CF) patients has led to the use of colistin drug and the emergence of colistin-resistant Gram-negative bacteria. The aim of this study was to compare the disk diffusion and Etest methods for colistin susceptibility testing on MDR bacteria associated with CF from Marseille, France. Forty-nine MDR clinical isolates (27 Stenotrophomonas maltophilia, 22 Achromobacter xylosoxidans) were used in this study. Disk diffusion and Etest assays were used to assess the reliability of these two techniques...
November 2013: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/23295930/biofilm-compared-to-conventional-antimicrobial-susceptibility-of-stenotrophomonas-maltophilia-isolates-from-cystic-fibrosis-patients
#16
Kitty Wu, Yvonne C W Yau, Larissa Matukas, Valerie Waters
Stenotrophomonas maltophilia is a multidrug-resistant organism increasingly isolated from the lungs of cystic fibrosis (CF) patients. One hundred twenty-five S. maltophilia isolates from 85 CF patients underwent planktonic and biofilm susceptibility testing against 9 different antibiotics, alone and in double antibiotic combinations. When S. maltophilia isolates were grown as a biofilm, 4 of the 10 most effective antibiotic combinations included high-dose levofloxacin and 7 of the 10 combinations included colistin at doses achievable by aerosolization...
March 2013: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/23113657/antimicrobial-susceptibility-and-combination-testing-of-invasive-stenotrophomonas-maltophilia-isolates
#17
Deirdre Church, Tracie Lloyd, Gisele Peirano, Johann Pitout
BACKGROUND: Treatment of invasive Stenotrophomonas maltophilia infections is difficult due to this organism's inherent multidrug resistance and increasing resistance to trimethoprim-sulfamethoxazole via acquisition of the sul genes. METHODS: In vitro antibiotic susceptibility testing was performed using a customized broth microdilution panel. Combination testing for tigecycline with anti-Stenotrophomonas agents (i.e. colistin, ticarcillin-clavulanate, ceftazidime, and levofloxacin) was done using the cross Etest method...
April 2013: Scandinavian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/22702735/proteomic-analysis-of-clinical-isolate-of-stenotrophomonas-maltophilia-with-blandm-1-blal1-and-blal2-%C3%AE-lactamase-genes-under-imipenem-treatment
#18
Wei Liu, Dayang Zou, Xuesong Wang, XueLian Li, Li Zhu, Zhitao Yin, Zhan Yang, Xiao Wei, Li Han, Yufei Wang, Changlin Shao, Simiao Wang, Xiang He, Dawei Liu, Feng Liu, Jie Wang, Liuyu Huang, Jing Yuan
The co-occurrence of L1 and AmpR-L2 with bla(NDM-1) gene with an upstream 250-bp promoter was detected in a clinical isolate of Stenotrophomonas maltophilia DCPS-01, which was resistant to all β-lactams and sensitive only to colistin and fluoroquinolones. To investigate expression of resistance genes and the molecular mechanisms of bacteria resistance to carbapenems, proteomic profiles of the isolate was passaged with and without the drug by using 2D-PAGE. The results showed that 33 genes exhibiting a ≥3-fold change were identified as candidates that may help S...
August 3, 2012: Journal of Proteome Research
https://www.readbyqxmd.com/read/22624022/stenotrophomonas-maltophilia-infections-in-a-general-hospital-patient-characteristics-antimicrobial-susceptibility-and-treatment-outcome
#19
George Samonis, Drosos E Karageorgopoulos, Sofia Maraki, Panagiotis Levis, Dimitra Dimopoulou, Nikolaos A Spernovasilis, Diamantis P Kofteridis, Matthew E Falagas
INTRODUCTION: Stenotrophomonas maltophilia is acquiring increasing importance as a nosocomial pathogen. METHODS: We retrospectively studied the characteristics and outcome of patients with any type of S. maltophilia infection at the University Hospital of Heraklion, Crete, Greece, between 1/2005-12/2010. S. maltophilia antimicrobial susceptibility was tested with the agar dilution method. Prognostic factors for all-cause in-hospital mortality were assessed with multivariate logistic regression...
2012: PloS One
https://www.readbyqxmd.com/read/22585220/combination-antimicrobial-susceptibility-testing-of-multidrug-resistant-stenotrophomonas-maltophilia-from-cystic-fibrosis-patients
#20
K E N Milne, I M Gould
Stenotrophomonas maltophilia is increasingly being isolated from the respiratory tract of individuals with cystic fibrosis, and, because of its multidrug-resistant nature, the selection of suitable treatment regimens can be problematical. Etest methodology was used to facilitate MIC and antimicrobial combination testing on 80 isolates of S. maltophilia cultured from the respiratory tract of Scottish individuals with cystic fibrosis between 2001 and 2010. The overall rate of susceptibility for the 1,410 MIC tests was 23...
August 2012: Antimicrobial Agents and Chemotherapy
keyword
keyword
73933
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"