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Joseph J Kim, Neal K Bennett, Mitchel S Devita, Sanjay Chahar, Satish Viswanath, Eunjee A Lee, Giyoung Jung, Paul P Shao, Erin P Childers, Shichong Liu, Anthony Kulesa, Benjamin A Garcia, Matthew L Becker, Nathaniel S Hwang, Anant Madabhushi, Michael P Verzi, Prabhas V Moghe
While distinct stem cell phenotypes follow global changes in chromatin marks, single-cell chromatin technologies are unable to resolve or predict stem cell fates. We propose the first such use of optical high content nanoscopy of histone epigenetic marks (epi-marks) in stem cells to classify emergent cell states. By combining nanoscopy with epi-mark textural image informatics, we developed a novel approach, termed EDICTS (Epi-mark Descriptor Imaging of Cell Transitional States), to discern chromatin organizational changes, demarcate lineage gradations across a range of stem cell types and robustly track lineage restriction kinetics...
January 4, 2017: Scientific Reports
Chantal M I Beijersbergen, Urs Granacher, Martijn Gäbler, Paul DeVita, Tibor Hortobágyi
BACKGROUND: Aging is associated with slowed gait and old compared with young adults generally walk with greater positive hip work (H1) and reduced positive ankle work (A2). The role of exercise interventions on old adults' gait mechanics that underlie training-induced improvements in gait velocity is unclear. We examined the effects of lower extremity power training and detraining on old adults' gait kinetics. METHODS: As part of the Potsdam Gait Study (POGS), healthy old adults completed a no-intervention control period (69...
December 21, 2016: Gait & Posture
Robert DeVita, Richard G Barr
OBJECTIVES: To evaluate the effect of precompression on power Doppler visualization of blood flow in breast masses. METHODS: This Institutional Review Board-approved and Health Insurance Portability and Accountability Act-compliant study evaluated 30 patients with breast masses (16 benign and 14 malignant) undergoing ultrasound-guided breast biopsy. A computational mathematics program was used to calculate the number of color pixels in a region of interest at various degrees of compression of the breast by the transducer...
November 30, 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
Erik R Vanderlip, Benjamin F Henwood, Debra R Hrouda, Piper S Meyer, Maria Monroe-DeVita, Lynette M Studer, April J Schweikhard, Lorna L Moser
OBJECTIVE: Assertive community treatment (ACT) is one of the few evidence-based practices for adults with severe mental illness. Interest has slowly waned for ACT implementation. Yet ACT remains an appealing services platform to achieve the triple aim of health care reform (improved health outcomes, reduced cost, and improved satisfaction) through integration of primary care and behavioral health services. This review highlights the evidence for ACT to improve general medical outcomes, reduce treatment costs, and increase access to treatment...
December 1, 2016: Psychiatric Services: a Journal of the American Psychiatric Association
Maria Devita, Sonia Montemurro, Sara Ramponi, Maurizio Marvisi, Daniele Villani, Maria Clara Raimondi, Maria Luisa Rusconi, Sara Mondini
Obstructive sleep apnea syndrome is a sleep disorder that may affect many brain functions. We are interested in the cognitive consequences of the condition with regard to the quality of life of individuals with this disorder. A debate is still underway as to whether cognitive difficulties caused by obstructive sleep apnea actually induce a "pseudodementia" pattern. This work provides a brief overview of the main controversies currently surrounding this issue. We report findings and opinions on structural and cognitive brain changes in individuals affected by obstructive sleep apnea by highlighting the involvement of executive functions and the possible reversibility of signs following-treatment with continuous positive airway pressure...
November 15, 2016: Journal of Clinical and Experimental Neuropsychology
Collin D Bowersock, Richard W Willy, Paul DeVita, John D Willson
The purpose of this study was to examine the effects of step length and foot strike pattern along with their interaction on tibiofemoral joint (TFJ) and medial compartment TFJ kinetics during running. Nineteen participants ran with a rear foot strike pattern at their preferred speed using a short (-10%), preferred, and long (+10%) step length. These step length conditions were then repeated using a forefoot strike pattern. Regardless of foot strike pattern, a 10% shorter step length resulted in decreased peak contact force, force impulse per step, force impulse per kilometre, and average loading rate at the TFJ and medial compartment, while a 10% increased step length had the opposite effects (all P < 0...
November 1, 2016: Journal of Sports Sciences
Jeffrey B Cooper, Barry S Issenberg, Michael A DeVita, Ronnie Glavin
No abstract text is available yet for this article.
October 2016: Simulation in Healthcare: Journal of the Society for Simulation in Healthcare
Tomasz M Beer, Vinay Prasad
No abstract text is available yet for this article.
January 1, 2017: JAMA Oncology
Chantal M I Beijersbergen, Urs Granacher, Martijn Gäbler, Paul Devita, Tibor Hortobágyi
INTRODUCTION: Slow gait predicts many adverse clinical outcomes in old adults, but the mechanisms of how power training can minimize the age-related loss of gait velocity is unclear. We examined the effects of 10 wk of lower extremity power training and detraining on healthy old adults' lower extremity muscle power and gait kinematics. METHODS: As part of the Potsdam Gait Study, participants started with 10 wk of power training followed by 10 wk of detraining (n = 16), and participants started with a 10-wk control period followed by 10 wk of power training (n = 16)...
January 2017: Medicine and Science in Sports and Exercise
Jason T Jakiela, Paul DeVita, Daniel P Beavers, Stephen P Messier
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
Stephen P Messier, David F Martin, Shannon L Mihalko, Edward H Ip, Paul DeVita, D Wayne Cannon, Monica Munsey, Danielle Beringer, Santiago Saldana, Rebecca E Fellin, Joseph F Seay
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
Azzour D Hazzan, Candice Halinski, Sofia Agoritsas, Steven Fishbane, Maria V DeVita
Advanced CKD is a period of CKD that differs greatly from earlier stages of CKD in terms of treatment goals. Treatment during this period presents particular challenges as further loss of kidney function heralds the need for renal replacement therapy. Successful management during this period increases the likelihood of improved transitions to ESRD. However, there are substantial barriers to optimal advanced CKD care. In this review, we will discuss advanced CKD definitions and epidemiology and outcomes.
July 2016: Advances in Chronic Kidney Disease
Maria V DeVita
No abstract text is available yet for this article.
July 2016: Advances in Chronic Kidney Disease
Tanjim Sultana, Maria V DeVita, Michael F Michelis
PURPOSE: Functional iron deficiency (FID) is a major cause of persistent anemia in dialysis patients and also contributes to a suboptimal response to erythropoietin (Epo) administration. Vitamin C acts as an enzyme cofactor and enhances mobilization of the ferrous form of iron to transferrin thus increasing its bioavailability. High-dose intravenous vitamin C has been shown to decrease the Epo requirement and improve hemoglobin levels in previous studies. This study assessed the effect of low-dose oral vitamin C on possible reduction in Epo dose requirements in stable hemodialysis patients with FID...
September 2016: International Urology and Nephrology
Michael A DeVita, Clifton W Callaway, Charissa Pacella, Maria Mori Brooks, John Lutz, Susan Stuart
BACKGROUND: In the United States, organ donation after circulatory death (DCD) determination is increasing among those who are removed from life-sustaining therapy but is rare when death is unexpected. We created a program for uncontrolled DCD (uDCD). METHODS: A comprehensive program was created to train personnel to identify and respond quickly to potential donors after unexpected death. The process termed Condition T was implemented in the emergency department (ED) of 2 academic medical centers...
March 2016: Progress in Transplantation
Dale S Hardy, Devita T Stallings, Jane T Garvin, Francine C Gachupin, Hongyan Xu, Susan B Racette
BACKGROUND: The aim of the present study was to determine the best anthropometric discriminators of type 2 diabetes mellitus (T2DM) among White and Black males and females in a large US sample. METHODS: We used Atherosclerosis Risk in Communities study baseline data (1987-89) from 15 242 participants (1827 with T2DM) aged 45-65 years. Anthropometric measures included a body shape index (ABSI), body adiposity index (BAI), body mass index, waist circumference (WC), waist:  height ratio (WHtR), and waist:  hip ratio (WHR)...
April 23, 2016: Journal of Diabetes
Angela L Rollins, Marina Kukla, Gary Morse, Louanne Davis, Michael Leiter, Maria Monroe-DeVita, Mindy E Flanagan, Alissa Russ, Sara Wasmuth, Johanne Eliacin, Linda Collins, Michelle P Salyers
OBJECTIVES: Prior research found preliminary effectiveness for Burnout Reduction: Enhanced Awareness, Tools, Handouts, and Education (BREATHE), a daylong workshop for reducing burnout among behavioral health providers. Using a longer follow-up compared with prior research, this study compared the effectiveness of BREATHE and a control condition. METHODS: Behavioral health providers (N=145) from three U.S. Department of Veterans Affairs facilities and two social service agencies were randomly assigned to BREATHE or person-centered treatment planning...
August 1, 2016: Psychiatric Services: a Journal of the American Psychiatric Association
Vincent T DeVita, George P Canellos
This article highlights the important collaboration between the U.S. NCI in Bethesda, Maryland and the Istituto Tumori in Milan, Italy that had a major impact on the development of curative regimens for breast cancer, Hodgkin's disease and diffuse large B cell lymphoma.In addition to his contribution to developing new therapies, Gianni Bonadonna played an important role in bringing highly focused, disciplined, ethical clinical trials to the European continent.
March 2016: Tumori
Vincent T DeVita
No abstract text is available yet for this article.
March 2016: Oncology (Williston Park, NY)
Paul DeVita, Patrick Rider, Tibor Hortobágyi
A consensus exists that high knee joint forces are a precursor to knee osteoarthritis and weight loss reduces these forces. Because large weight loss also leads to increased step length and walking velocity, knee contact forces may be reduced less than predicted by the magnitude of weight loss. The purpose was to determine the effects of weight loss on knee muscle and joint loads during walking in Class III obese adults. We determined through motion capture, force platform measures and biomechanical modeling the effects of weight loss produced by gastric bypass surgery over one year on knee muscle and joint loads during walking at a standard, controlled velocity and at self-selected walking velocities...
March 2016: Gait & Posture
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