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https://www.readbyqxmd.com/read/29022278/alzheimer-caf%C3%A3-an-approach-focused-on-alzheimer-s-patients-but-with-remarkable-values-on-the-quality-of-life-of-their-caregivers
#1
Paola Merlo, Maria Devita, Alessandra Mandelli, Maria Luisa Rusconi, Raquel Taddeucci, Alice Terzi, Gianpiero Arosio, Maria Bellati, Maura Gavazzeni, Sara Mondini
BACKGROUND: Alzheimer's disease (AD) affects the global quality of life of persons who suffer from it and their caregivers, because of the behavioral and psychological consequences associated with the pathology and its caring. The Alzheimer Café (AC) is one example of approach aimed to help persons and caregivers deal with their disease. AIM: This is a pilot study focusing on the efficacy of AC in relieving caregivers' and persons' burdens due to dementia. METHODS: The quality of life of both caregivers and persons who attended the AC was compared with the quality of life of those who did not...
October 11, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29016393/biomechanical-implications-of-training-volume-and-intensity-in-aging-runners
#2
Max R Paquette, Paul DeVita, D S Blaise Williams
Running speed is slower in middle-aged compared to younger runners due to reduced ankle but not hip and knee kinetic output. Running-specific training helps attenuate age-related declines in measures of endurance, muscle strength and gait speed. Considering the adaptability of the human body in response to imposed stresses, maintaining training volume and intensity may play a role in modifying running biomechanics in middle-aged runners. PURPOSE: To compare running biomechanics between young and middle-aged runners when controlling for the confounding effects of training volume and intensity...
October 9, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28993211/global-cognitive-profile-and-different-components-of-reaction-times-in-obstructive-sleep-apnea-syndrome-effects-of-continuous-positive-airway-pressure-over-time
#3
Maria Devita, Andrea Zangrossi, Maurizio Marvisi, Paola Merlo, Maria Luisa Rusconi, Sara Mondini
Obstructive sleep apnea syndrome (OSAS) has been recurrently associated with cognitive and psychomotor impairments. However, the occurrence and possible reversibility of these deficits are still extremely controversial, also as a result of different methodologies adopted used by scholars. The aim of the present study was to compare over time the global cognitive profile of patients with OSAS undergoing the continuous positive airway pressure treatment (CPAP; N=23) with that of patients with OSAS who were not (N=10)...
October 6, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/28975489/use-of-lung-ultrasonography-to-determine-the-accuracy-of-clinically-estimated-dry-weight-in-chronic-hemodialysis-patients
#4
Chuan Jiang, Satyam Patel, Andrew Moses, Maria V DeVita, Michael F Michelis
PURPOSE: The use of lung ultrasound (LUS) to identify extravascular lung water has received increasing acceptance. Sonographic B-lines, discrete vertical lines that originate from the pleura, represent pulmonary edema and are correlated with the accumulation of fluid. The goal of this study was to evaluate the utility of LUS to determine the accuracy of prescribed dry weight (DW) in chronic hemodialysis (HD) patients and to ascertain the adequacy of fluid removal. METHODS: LUS was scheduled to be performed pre- and post-HD in 20 patients...
October 3, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28700954/cognitive-and-motor-reaction-times-in-obstructive-sleep-apnea-syndrome-a-study-based-on-computerized-measures
#5
Maria Devita, Sonia Montemurro, Andrea Zangrossi, Sara Ramponi, Maurizio Marvisi, Daniele Villani, Maria Clara Raimondi, Paola Merlo, Maria Luisa Rusconi, Sara Mondini
Obstructive Sleep Apnea Syndrome (OSAS) is mainly associated with executive dysfunction. Although delayed reaction times (RTs) in patients with OSAS have been reported, sensitivity of processing speed has not been adequately assessed. This study suggests sensitive and reliable measures to clarify whether different components of information processing speed, i.e. cognitive and motor responses, are equally impaired in OSAS. Thirty-three patients with OSAS were compared with thirty healthy controls. The MoCA test was administered to assess participants' global neuropsychological profile...
July 9, 2017: Brain and Cognition
https://www.readbyqxmd.com/read/28673223/proceedings-of-the-12th-international-conference-on-rapid-response-systems-and-medical-emergency-teams
#6
D Jones, J Holmes, J Currey, E Fugaccia, A J Psirides, M Y Singh, G J Fennessy, K Hillman, D V Pilcher, R Bellomo, M DeVita
Rapid Response Teams (RRTs) have been introduced into hospitals worldwide in an effort to improve the outcomes of deteriorating hospitalised patients. Recently, there has been increased awareness of the need to develop systems other than RRTs for deteriorating patients. In May 2016, the 12th International Conference on Rapid Response Systems and Medical Emergency Teams was held in Melbourne. This represented a collaboration between the newly constituted International Society for Rapid Response Systems (iSRRS) and the Australian and New Zealand Intensive Care Society...
July 2017: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/28661729/epr-and-udcdd-a-response-to-commentaries
#7
Arjun Prabhu, Lisa S Parker, Michael A DeVita
No abstract text is available yet for this article.
July 2017: American Journal of Bioethics: AJOB
https://www.readbyqxmd.com/read/28598910/power-training-induced-increases-in-muscle-activation-during-gait-in-old-adults
#8
Chantal M I Beijersbergen, Urs Granacher, Martijn Gäbler, Paul Devita, Tibor Hortobágyi
INTRODUCTION/PURPOSE: Aging modifies neuromuscular activation of agonist and antagonist muscles during walking. Power training can evoke adaptations in neuromuscular activation that underlie gains in muscle strength and power but it is unknown if these adaptations transfer to dynamic tasks such as walking. We examined the effects of lower-extremity power training on neuromuscular activation during level gait in old adults. METHODS: Twelve community-dwelling old adults (age ≥ 65 yr) completed a 10-wk lower-extremity power training program and 13 old adults completed a 10-wk control period...
November 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28569407/agreement-between-an-automated-volume-breast-scanner-and-handheld-ultrasound-for-diagnostic-breast-examinations
#9
Richard G Barr, Robert DeVita, Stamatia Destounis, Federica Manzoni, Annalisa De Silvestri, Carmine Tinelli
OBJECTIVES: To compare the agreement and interobserver variability of diagnostic handheld ultrasound (US) and a single volume on an automated breast volume scanner (ABVS) and to determine whether there was a significant difference if the ABVS was used by a sonographer or mammographic technologist. METHODS: Ninety patients scheduled for diagnostic US examinations were randomized to either handheld US or the ABVS first. The AVBS was randomized between a sonographer and a mammographic technologist performing the study...
October 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28561660/the-oncology-care-model-perspectives-from-the-centers-for-medicare-amp-medicaid-services-and-participating-oncology-practices-in-academia-and-the-community
#10
Ron Kline, Kerin Adelson, Jeffrey J Kirshner, Larissa M Strawbridge, Marsha Devita, Naralys Sinanis, Patrick H Conway, Ethan Basch
Cancer care delivery in the United States is often fragmented and inefficient, imposing substantial burdens on patients. Costs of cancer care are rising more rapidly than other specialties, with substantial regional differences in quality and cost. The Centers for Medicare & Medicaid Services (CMS) Innovation Center (CMMIS) recently launched the Oncology Care Model (OCM), which uses payment incentives and practice redesign requirements toward the goal of improving quality while controlling costs. As of March 2017, 190 practices were participating, with approximately 3,200 oncologists providing care for approximately 150,000 unique beneficiaries per year (approximately 20% of the Medicare Fee-for-Service population receiving chemotherapy for cancer)...
2017: American Society of Clinical Oncology Educational Book
https://www.readbyqxmd.com/read/28452911/the-effect-of-hiv-centered-obstetric-care-on-perinatal-outcomes-among-a-cohort-of-women-living-with-hiv
#11
Anna M Powell, Julia M DeVita, Amartha Ogburu-Ogbonnaya, Andrea Peterson, Gweneth B Lazenby
BACKGROUND: Elimination of perinatal transmission is possible but limited by missed care opportunities. Our objective was to investigate the effects of HIV-centered obstetric care (HCC) on missed care opportunities and perinatal HIV transmission in 2 obstetric cohorts at our institution from 2000 to 2014. METHODS: This was a retrospective cohort study of HIV-exposed mother-infant pairs delivering from 2000 to 2014, analyzed according to SQUIRE 2.0 (Standards for Quality Improvement Reporting Excellence) guidelines...
August 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28430068/caring-for-patients-or-organs-new-therapies-raise-new-dilemmas-in-the-emergency-department
#12
Arjun Prabhu, Lisa S Parker, Michael A DeVita
Two potentially lifesaving protocols, emergency preservation and resuscitation (EPR) and uncontrolled donation after circulatory determination of death (uDCDD), currently implemented in some U.S. emergency departments (EDs), have similar eligibility criteria and initial technical procedures, but critically different goals. Both follow unsuccessful cardiopulmonary resuscitation and induce hypothermia to "buy time": one in trauma patients suffering cardiac arrest, to enable surgical repair, and the other in patients who unexpectedly die in the ED, to enable organ donation...
May 2017: American Journal of Bioethics: AJOB
https://www.readbyqxmd.com/read/28282532/study-of-%C3%AE-h2ax-as-dna-double-strand-break-biomarker-in-resident-living-in-high-natural-radiation-area-of-mamuju-west-sulawesi
#13
Iin Kurnia Hasan Basri, Darlina Yusuf, Tur Rahardjo, Siti Nurhayati, Devita Tetriana, Dwi Ramadhani, Zubaidah Alatas, Sofiati Purnami, Teja Kisnanto, Yanti Lusiyanti, Mukh Syaifudin
High expression of phospho histone γ-H2AX, a sensitive marker of double stranded DNA damage, is believed to be an indication of defective DNA repair pathway or genomic instability that may cause mutations and ultimately cancer. DNA damage can be caused by ionizing radiation exposure. Beside in medical treatment/diagnosis or industry, ionizing radiation exposure can also be found in naturally in regions of high natural back ground radiation. In this study we collect the blood from 45 volunteers living in Mamuju, a region with highest natural radiation in Indonesia (dose of ∼7 mSv/year)...
May 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28280975/the-effect-of-nordic-hamstring-strength-training-on-muscle-architecture-stiffness-and-strength
#14
RANDOMIZED CONTROLLED TRIAL
Kayla D Seymore, Zachary J Domire, Paul DeVita, Patrick M Rider, Anthony S Kulas
PURPOSE: Hamstring strain injury is a frequent and serious injury in competitive and recreational sports. While Nordic hamstring (NH) eccentric strength training is an effective hamstring injury-prevention method, the protective mechanism of this exercise is not understood. Strength training increases muscle strength, but also alters muscle architecture and stiffness; all three factors may be associated with reducing muscle injuries. The purpose of this study was to examine the effects of NH eccentric strength training on hamstring muscle architecture, stiffness, and strength...
May 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28252959/microscale-high-throughput-experimentation-as-an-enabling-technology-in-drug-discovery-application-in-the-discovery-of-piperidinyl-pyridinyl-1h-benzimidazole-diacylglycerol-acyltransferase-1-inhibitors
#15
Tim Cernak, Nathan J Gesmundo, Kevin Dykstra, Yang Yu, Zhicai Wu, Zhi-Cai Shi, Petr Vachal, Donald Sperbeck, Shuwen He, Beth Ann Murphy, Lisa Sonatore, Steven Williams, Maria Madeira, Andreas Verras, Maud Reiter, Claire Heechoon Lee, James Cuff, Edward C Sherer, Jeffrey Kuethe, Stephen Goble, Nicholas Perrotto, Shirly Pinto, Dong-Ming Shen, Ravi Nargund, James Balkovec, Robert J DeVita, Spencer D Dreher
Miniaturization and parallel processing play an important role in the evolution of many technologies. We demonstrate the application of miniaturized high-throughput experimentation methods to resolve synthetic chemistry challenges on the frontlines of a lead optimization effort to develop diacylglycerol acyltransferase (DGAT1) inhibitors. Reactions were performed on ∼1 mg scale using glass microvials providing a miniaturized high-throughput experimentation capability that was used to study a challenging SNAr reaction...
May 11, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28238986/symptomology-of-elevated-blood-pressure-in-black-women-with-hypertension
#16
Devita T Stallings, Joanne Kraenzle Schneider
Understanding factors that influence hypertension self-management may improve blood pressure control in Black women; however, little is known about Black women's perceptions of symptoms associated with hypertension. In this study, using the revised version of the Illness Perception Questionnaire (IPQ-R), we examined Black women's perceptions of symptoms that they associate with hypertension. While over half (52.5%) reported no symptoms of high blood pressure, 41.3% of the women reported one to six symptoms they attributed to high blood pressure...
2017: Journal of Health Care for the Poor and Underserved
https://www.readbyqxmd.com/read/28228115/weight-loss-and-exercise-for-communities-with-arthritis-in-north-carolina-we-can-design-and-rationale-of-a-pragmatic-assessor-blinded-randomized-controlled-trial
#17
Stephen P Messier, Leigh F Callahan, Daniel P Beavers, Kate Queen, Shannon L Mihalko, Gary D Miller, Elena Losina, Jeffrey N Katz, Richard F Loeser, Sara A Quandt, Paul DeVita, David J Hunter, Mary F Lyles, Jovita Newman, Betsy Hackney, Joanne M Jordan
BACKGROUND: Recently, we determined that in a rigorously monitored environment an intensive diet-induced weight loss of 10% combined with exercise was significantly more effective at reducing pain in men and women with symptomatic knee osteoarthritis (OA) than either intervention alone. Compared to previous long-term weight loss and exercise trials of knee OA, our intensive diet-induced weight loss and exercise intervention was twice as effective at reducing pain intensity. Whether these results can be generalized to less intensively monitored cohorts is unknown...
February 22, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28214426/reduced-step-length-reduces-knee-joint-contact-forces-during-running-following-anterior-cruciate-ligament-reconstruction-but-does-not-alter-inter-limb-asymmetry
#18
Collin D Bowersock, Richard W Willy, Paul DeVita, John D Willson
BACKGROUND: Anterior cruciate ligament reconstruction is associated with early onset knee osteoarthritis. Running is a typical activity following this surgery, but elevated knee joint contact forces are thought to contribute to osteoarthritis degenerative processes. It is therefore clinically relevant to identify interventions to reduce contact forces during running among individuals after anterior cruciate ligament reconstruction. The primary purpose of this study was to evaluate the effect of reducing step length during running on patellofemoral and tibiofemoral joint contact forces among people with a history of anterior cruciate ligament reconstruction...
March 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28141847/best-anthropometric-discriminators-of-incident-type-2-diabetes-among-white-and-black-adults-a-longitudinal-aric-study
#19
Dale S Hardy, Devita T Stallings, Jane T Garvin, Hongyan Xu, Susan B Racette
OBJECTIVE: To determine which anthropometric measures are the strongest discriminators of incident type 2 diabetes (T2DM) among White and Black males and females in a large U.S. cohort. METHODS: We used Atherosclerosis Risk in Communities study data from 12,121 participants aged 45-64 years without diabetes at baseline who were followed for over 11 years. Anthropometric measures included a body shape index (ABSI), body adiposity index (BAI), body mass index (BMI), waist circumference (WC), waist to hip ratio (WHR), waist to height ratio (WHtR), and waist to hip to height ratio (WHHR)...
2017: PloS One
https://www.readbyqxmd.com/read/28051095/optical-high-content-nanoscopy-of-epigenetic-marks-decodes-phenotypic-divergence-in-stem-cells
#20
Joseph J Kim, Neal K Bennett, Mitchel S Devita, Sanjay Chahar, Satish Viswanath, Eunjee A Lee, Giyoung Jung, Paul P Shao, Erin P Childers, Shichong Liu, Anthony Kulesa, Benjamin A Garcia, Matthew L Becker, Nathaniel S Hwang, Anant Madabhushi, Michael P Verzi, Prabhas V Moghe
While distinct stem cell phenotypes follow global changes in chromatin marks, single-cell chromatin technologies are unable to resolve or predict stem cell fates. We propose the first such use of optical high content nanoscopy of histone epigenetic marks (epi-marks) in stem cells to classify emergent cell states. By combining nanoscopy with epi-mark textural image informatics, we developed a novel approach, termed EDICTS (Epi-mark Descriptor Imaging of Cell Transitional States), to discern chromatin organizational changes, demarcate lineage gradations across a range of stem cell types and robustly track lineage restriction kinetics...
January 4, 2017: Scientific Reports
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