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https://www.readbyqxmd.com/read/28452911/the-effect-of-hiv-centered-obstetric-care-on-perinatal-outcomes-among-a-cohort-of-women-living-with-hiv
#1
Anna M Powell, Julia M DeVita, Amartha Ogburu-Ogbonnaya, Andrea Peterson, Gweneth B Lazenby
BACKGROUND: Elimination of perinatal transmission is possible but limited by missed care opportunities. Our objective was to investigate the effects of HIV-centered obstetric care (HCC) on missed care opportunities and perinatal HIV transmission in two obstetric cohorts at our institution from 2000-2014. METHODS: This was a retrospective cohort study of HIV-exposed mother-infant pairs delivering from 2000-2014, analyzed according to SQUIRE 2.0 (Standards for Quality Improvement Reporting Excellence) guidelines...
April 26, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28430068/caring-for-patients-or-organs-new-therapies-raise-new-dilemmas-in-the-emergency-department
#2
Arjun Prabhu, Lisa S Parker, Michael A DeVita
Two potentially lifesaving protocols, emergency preservation and resuscitation (EPR) and uncontrolled donation after circulatory determination of death (uDCDD), currently implemented in some U.S. emergency departments (EDs), have similar eligibility criteria and initial technical procedures, but critically different goals. Both follow unsuccessful cardiopulmonary resuscitation and induce hypothermia to "buy time": one in trauma patients suffering cardiac arrest, to enable surgical repair, and the other in patients who unexpectedly die in the ED, to enable organ donation...
May 2017: American Journal of Bioethics: AJOB
https://www.readbyqxmd.com/read/28282532/study-of-%C3%AE-h2ax-as-dna-double-strand-break-biomarker-in-resident-living-in-high-natural-radiation-area-of-mamuju-west-sulawesi
#3
Iin Kurnia Hasan Basri, Darlina Yusuf, Tur Rahardjo, Siti Nurhayati, Devita Tetriana, Dwi Ramadhani, Zubaidah Alatas, Sofiati Purnami, Teja Kisnanto, Yanti Lusiyanti, Mukh Syaifudin
High expression of phospho histone γ-H2AX, a sensitive marker of double stranded DNA damage, is believed to be an indication of defective DNA repair pathway or genomic instability that may cause mutations and ultimately cancer. DNA damage can be caused by ionizing radiation exposure. Beside in medical treatment/diagnosis or industry, ionizing radiation exposure can also be found in naturally in regions of high natural back ground radiation. In this study we collect the blood from 45 volunteers living in Mamuju, a region with highest natural radiation in Indonesia (dose of ∼7 mSv/year)...
May 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28280975/the-effect-of-nordic-hamstring-strength-training-on-muscle-architecture-stiffness-and-strength
#4
Kayla D Seymore, Zachary J Domire, Paul DeVita, Patrick M Rider, Anthony S Kulas
PURPOSE: Hamstring strain injury is a frequent and serious injury in competitive and recreational sports. While Nordic hamstring (NH) eccentric strength training is an effective hamstring injury-prevention method, the protective mechanism of this exercise is not understood. Strength training increases muscle strength, but also alters muscle architecture and stiffness; all three factors may be associated with reducing muscle injuries. The purpose of this study was to examine the effects of NH eccentric strength training on hamstring muscle architecture, stiffness, and strength...
May 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28252959/microscale-high-throughput-experimentation-as-an-enabling-technology-in-drug-discovery-application-in-the-discovery-of-piperidinyl-pyridinyl-1h-benzimidazole-diacylglycerol-acyltransferase-1-inhibitors
#5
Tim Cernak, Nathan J Gesmundo, Kevin Dykstra, Yang Yu, Zhicai Wu, Zhi-Cai Shi, Petr Vachal, Donald Sperbeck, Shuwen He, Beth Ann Murphy, Lisa Sonatore, Steven Williams, Maria Madeira, Andreas Verras, Maud Reiter, Claire Heechoon Lee, James Cuff, Edward C Sherer, Jeffrey Kuethe, Stephen Goble, Nicholas Perrotto, Shirly Pinto, Dong-Ming Shen, Ravi Nargund, James Balkovec, Robert J DeVita, Spencer D Dreher
Miniaturization and parallel processing play an important role in the evolution of many technologies. We demonstrate the application of miniaturized high-throughput experimentation methods to resolve synthetic chemistry challenges on the frontlines of a lead optimization effort to develop diacylglycerol acyltransferase (DGAT1) inhibitors. Reactions were performed on ∼1 mg scale using glass microvials providing a miniaturized high-throughput experimentation capability that was used to study a challenging SNAr reaction...
May 11, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28238986/symptomology-of-elevated-blood-pressure-in-black-women-with-hypertension
#6
Devita T Stallings, Joanne Kraenzle Schneider
Understanding factors that influence hypertension self-management may improve blood pressure control in Black women; however, little is known about Black women's perceptions of symptoms associated with hypertension. In this study, using the revised version of the Illness Perception Questionnaire (IPQ-R), we examined Black women's perceptions of symptoms that they associate with hypertension. While over half (52.5%) reported no symptoms of high blood pressure, 41.3% of the women reported one to six symptoms they attributed to high blood pressure...
2017: Journal of Health Care for the Poor and Underserved
https://www.readbyqxmd.com/read/28228115/weight-loss-and-exercise-for-communities-with-arthritis-in-north-carolina-we-can-design-and-rationale-of-a-pragmatic-assessor-blinded-randomized-controlled-trial
#7
Stephen P Messier, Leigh F Callahan, Daniel P Beavers, Kate Queen, Shannon L Mihalko, Gary D Miller, Elena Losina, Jeffrey N Katz, Richard F Loeser, Sara A Quandt, Paul DeVita, David J Hunter, Mary F Lyles, Jovita Newman, Betsy Hackney, Joanne M Jordan
BACKGROUND: Recently, we determined that in a rigorously monitored environment an intensive diet-induced weight loss of 10% combined with exercise was significantly more effective at reducing pain in men and women with symptomatic knee osteoarthritis (OA) than either intervention alone. Compared to previous long-term weight loss and exercise trials of knee OA, our intensive diet-induced weight loss and exercise intervention was twice as effective at reducing pain intensity. Whether these results can be generalized to less intensively monitored cohorts is unknown...
February 22, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28214426/reduced-step-length-reduces-knee-joint-contact-forces-during-running-following-anterior-cruciate-ligament-reconstruction-but-does-not-alter-inter-limb-asymmetry
#8
Collin D Bowersock, Richard W Willy, Paul DeVita, John D Willson
BACKGROUND: Anterior cruciate ligament reconstruction is associated with early onset knee osteoarthritis. Running is a typical activity following this surgery, but elevated knee joint contact forces are thought to contribute to osteoarthritis degenerative processes. It is therefore clinically relevant to identify interventions to reduce contact forces during running among individuals after anterior cruciate ligament reconstruction. The primary purpose of this study was to evaluate the effect of reducing step length during running on patellofemoral and tibiofemoral joint contact forces among people with a history of anterior cruciate ligament reconstruction...
February 10, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28141847/best-anthropometric-discriminators-of-incident-type-2-diabetes-among-white-and-black-adults-a-longitudinal-aric-study
#9
Dale S Hardy, Devita T Stallings, Jane T Garvin, Hongyan Xu, Susan B Racette
OBJECTIVE: To determine which anthropometric measures are the strongest discriminators of incident type 2 diabetes (T2DM) among White and Black males and females in a large U.S. cohort. METHODS: We used Atherosclerosis Risk in Communities study data from 12,121 participants aged 45-64 years without diabetes at baseline who were followed for over 11 years. Anthropometric measures included a body shape index (ABSI), body adiposity index (BAI), body mass index (BMI), waist circumference (WC), waist to hip ratio (WHR), waist to height ratio (WHtR), and waist to hip to height ratio (WHHR)...
2017: PloS One
https://www.readbyqxmd.com/read/28051095/optical-high-content-nanoscopy-of-epigenetic-marks-decodes-phenotypic-divergence-in-stem-cells
#10
Joseph J Kim, Neal K Bennett, Mitchel S Devita, Sanjay Chahar, Satish Viswanath, Eunjee A Lee, Giyoung Jung, Paul P Shao, Erin P Childers, Shichong Liu, Anthony Kulesa, Benjamin A Garcia, Matthew L Becker, Nathaniel S Hwang, Anant Madabhushi, Michael P Verzi, Prabhas V Moghe
While distinct stem cell phenotypes follow global changes in chromatin marks, single-cell chromatin technologies are unable to resolve or predict stem cell fates. We propose the first such use of optical high content nanoscopy of histone epigenetic marks (epi-marks) in stem cells to classify emergent cell states. By combining nanoscopy with epi-mark textural image informatics, we developed a novel approach, termed EDICTS (Epi-mark Descriptor Imaging of Cell Transitional States), to discern chromatin organizational changes, demarcate lineage gradations across a range of stem cell types and robustly track lineage restriction kinetics...
January 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28043055/hip-mechanics-underlie-lower-extremity-power-training-induced-increase-in-old-adults-fast-gait-velocity-the-potsdam-gait-study-pogs
#11
Chantal M I Beijersbergen, Urs Granacher, Martijn Gäbler, Paul DeVita, Tibor Hortobágyi
BACKGROUND: Aging is associated with slowed gait and old compared with young adults generally walk with greater positive hip work (H1) and reduced positive ankle work (A2). The role of exercise interventions on old adults' gait mechanics that underlie training-induced improvements in gait velocity is unclear. We examined the effects of lower extremity power training and detraining on old adults' gait kinetics. METHODS: As part of the Potsdam Gait Study (POGS), healthy old adults completed a no-intervention control period (69...
December 21, 2016: Gait & Posture
https://www.readbyqxmd.com/read/27925701/effect-of-precompression-on-the-power-doppler-assessment-of-breast-lesion-vascularity
#12
Robert DeVita, Richard G Barr
OBJECTIVES: To evaluate the effect of precompression on power Doppler visualization of blood flow in breast masses. METHODS: This Institutional Review Board-approved and Health Insurance Portability and Accountability Act-compliant study evaluated 30 patients with breast masses (16 benign and 14 malignant) undergoing ultrasound-guided breast biopsy. A computational mathematics program was used to calculate the number of color pixels in a region of interest at various degrees of compression of the breast by the transducer...
November 30, 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/27903142/systematic-literature-review-of-general-health-care-interventions-within-programs-of-assertive-community-treatment
#13
Erik R Vanderlip, Benjamin F Henwood, Debra R Hrouda, Piper S Meyer, Maria Monroe-DeVita, Lynette M Studer, April J Schweikhard, Lorna L Moser
OBJECTIVE: Assertive community treatment (ACT) is one of the few evidence-based practices for adults with severe mental illness. Interest has slowly waned for ACT implementation. Yet ACT remains an appealing services platform to achieve the triple aim of health care reform (improved health outcomes, reduced cost, and improved satisfaction) through integration of primary care and behavioral health services. This review highlights the evidence for ACT to improve general medical outcomes, reduce treatment costs, and increase access to treatment...
March 1, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/27845600/obstructive-sleep-apnea-and-its-controversial-effects-on-cognition
#14
Maria Devita, Sonia Montemurro, Sara Ramponi, Maurizio Marvisi, Daniele Villani, Maria Clara Raimondi, Maria Luisa Rusconi, Sara Mondini
Obstructive sleep apnea syndrome is a sleep disorder that may affect many brain functions. We are interested in the cognitive consequences of the condition with regard to the quality of life of individuals with this disorder. A debate is still underway as to whether cognitive difficulties caused by obstructive sleep apnea actually induce a "pseudodementia" pattern. This work provides a brief overview of the main controversies currently surrounding this issue. We report findings and opinions on structural and cognitive brain changes in individuals affected by obstructive sleep apnea by highlighting the involvement of executive functions and the possible reversibility of signs following-treatment with continuous positive airway pressure...
November 15, 2016: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/27800702/independent-effects-of-step-length-and-foot-strike-pattern-on-tibiofemoral-joint-forces-during-running
#15
Collin D Bowersock, Richard W Willy, Paul DeVita, John D Willson
The purpose of this study was to examine the effects of step length and foot strike pattern along with their interaction on tibiofemoral joint (TFJ) and medial compartment TFJ kinetics during running. Nineteen participants ran with a rear foot strike pattern at their preferred speed using a short (-10%), preferred, and long (+10%) step length. These step length conditions were then repeated using a forefoot strike pattern. Regardless of foot strike pattern, a 10% shorter step length resulted in decreased peak contact force, force impulse per step, force impulse per kilometre, and average loading rate at the TFJ and medial compartment, while a 10% increased step length had the opposite effects (all P < 0...
November 1, 2016: Journal of Sports Sciences
https://www.readbyqxmd.com/read/27749659/tribute-to-david-gaba-on-the-occasion-of-his-retiring-as-editor-in-chief-of-simulation-in-healthcare
#16
Jeffrey B Cooper, Barry S Issenberg, Michael A DeVita, Ronnie Glavin
No abstract text is available yet for this article.
October 2016: Simulation in Healthcare: Journal of the Society for Simulation in Healthcare
https://www.readbyqxmd.com/read/27631115/taking-care-of-our-friends-and-neighbors-devita-s-the-death-of-cancer-and-the-challenge-of-letting-go
#17
Tomasz M Beer, Vinay Prasad
No abstract text is available yet for this article.
January 1, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/27580150/kinematic-mechanisms-of-how-power-training-improves-healthy-old-adults-gait-velocity
#18
Chantal M I Beijersbergen, Urs Granacher, Martijn Gäbler, Paul Devita, Tibor Hortobágyi
INTRODUCTION: Slow gait predicts many adverse clinical outcomes in old adults, but the mechanisms of how power training can minimize the age-related loss of gait velocity is unclear. We examined the effects of 10 wk of lower extremity power training and detraining on healthy old adults' lower extremity muscle power and gait kinematics. METHODS: As part of the Potsdam Gait Study, participants started with 10 wk of power training followed by 10 wk of detraining (n = 16), and participants started with a 10-wk control period followed by 10 wk of power training (n = 16)...
January 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27361679/biomechanical-determinants-of-reduced-knee-joint-loads-in-patients-with-osteoarthritis-following-intensive-weight-loss-3110-board-175-june-3-2-00-pm-3-30-pm
#19
Jason T Jakiela, Paul DeVita, Daniel P Beavers, Stephen P Messier
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27359796/a-2-year-prospective-observational-study-to-determine-the-etiologic-factors-associated-with-overuse-running-injuries-652-june-1-2-45-pm-3-00-pm
#20
Stephen P Messier, David F Martin, Shannon L Mihalko, Edward H Ip, Paul DeVita, D Wayne Cannon, Monica Munsey, Danielle Beringer, Santiago Saldana, Rebecca E Fellin, Joseph F Seay
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
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