keyword
https://read.qxmd.com/read/36845969/block-copolymer-nanomicelle-encapsulated-curcumin-attenuates-cerebral-ischemia-injury-and-affects-stem-cell-marker-expression-by-inhibiting-lncrna-gas5
#21
JOURNAL ARTICLE
Fengguang Li, Yan Xu, Xinghua Wang, Xuan Cai, Wanli Li, Wei Cheng, Xing Li, Gangli Yan
Stroke has become the most common cause of death among residents in China, among which ischemic stroke accounts for the vast majority reaching 70% to 80%. It is of great importance to actively investigate the protective mechanism of cerebral ischemia injury after IS (ischemic stroke). We constructed cerebral ischemia injury models in vivo MACO rat and in vitro (oxygen-glucose deprivation cell model) and set up different interference groups. RT-PCR (reverse transcription PCR) was conducted to detect the expression of lncRNA in neuronal cells, brain tissue, and plasma of different groups, and ELISA (enzyme-linked immunosorbent assay) and western blot were used to detect the expression of the protein in neuronal cells, brain tissue, and plasma of different groups...
2023: Stem Cells International
https://read.qxmd.com/read/36814928/pyrolyzed-deketene-curcumin-controls-regulatory-t-cell-generation-and-gastric-cancer-metabolism-cooperate-with-2-deoxy-d-glucose
#22
JOURNAL ARTICLE
Takashi MaruYama, Hirofumi Miyazaki, Yun-Ji Lim, Jian Gu, Masaki Ishikawa, Taichi Yoshida, WanJun Chen, Yuji Owada, Hiroyuki Shibata
Pyrolyzed deketene curcumin GO-Y022 prevents carcinogenesis in a gastric cancer mouse model. However, it is still less clear if GO-Y022 affects tumor-induced immune suppression. In this study, we found that GO-Y022 inhibited Treg generation in the presence of transforming growth factor beta 1 (TGF-β). However, GO-Y022 showed less impact on Foxp3+ Tregs in the gastric tumor microenvironment. Gastric tumor cells produce a large amount of L-lactate in the presence of GO-Y022 and diminish the inhibitory role of GO-Y022 against Treg generation in response to TGF-β...
2023: Frontiers in Immunology
https://read.qxmd.com/read/36768681/cytotoxicity-of-isoxazole-curcumin-analogs-on-chronic-myeloid-leukemia-derived-k562-cell-lines-sensitive-and-resistant-to-imatinib
#23
JOURNAL ARTICLE
Giordana Feriotto, Paolo Marchetti, Riccardo Rondanin, Federico Tagliati, Serena Aguzzi, Simone Beninati, Fabio Casciano, Claudio Tabolacci, Carlo Mischiati
Despite curcumin (CUR) inhibiting cell proliferation in vitro by activating apoptotic cell death, its use in pharmacological therapy is hampered by poor solubility, low stability in biological fluids, and rapid removal from the body. Therefore, CUR-derivatives with better biological and chemical-physical characteristics are needed. The bis-ketone moiety of CUR strongly influences its stability in slightly alkaline solutions such as plasma. Here, we considered its replacement with isoxazole, beta-enamine, or oxime groups to obtain more stable derivatives...
January 25, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36628615/a-three-dimensional-spheroid-co-culture-system-of-neurons-and-astrocytes-derived-from-alzheimer-s-disease-patients-for-drug-efficacy-testing
#24
JOURNAL ARTICLE
HyunJung Park, Jaehyeon Kim, Chongsuk Ryou
Cell culture systems derived from the progenitor cells of human patients have many advantages over animal models for therapeutic drug testing and studies of disease pathogenesis. Here we describe a three-dimensional (3D) spheroid co-culture system of neurons and astrocytes derived from induced pluripotent stem cells-neural precursor cells (iPSCs-NPCs) of Alzheimer's disease (AD) patients or healthy individuals that can provide information on drug efficacy unobtainable by 2D co-culture or monoculture approaches...
January 11, 2023: Cell Proliferation
https://read.qxmd.com/read/36578323/ameliorative-effect-of-curcumin-nanoparticles-against-monosodium-iodoacetate-induced-knee-osteoarthritis-in-rats
#25
JOURNAL ARTICLE
Hadeer M Hamdalla, Rasha R Ahmed, Sanaa R Galaly, Ibrahim A Naguib, Badrah S Alghamdi, Osama M Ahmed, Ahmed Farghali, Manal Abdul-Hamid
AIM: This study is aimed at evaluating the use of curcumin-loaded polylactic-co-glycolic acid nanoparticles (CUR-loaded PLGA NPs) as a treatment against monosodium iodoacetate- (MIA-) induced knee OA. MATERIALS AND METHODS: Eighteen rats were assigned to three groups ( n = 6), namely, normal control group that received intra-articular injections (IAIs) of saline, an OA control group that received an IAIs of MIA (2 mg/50  μ L), and a treatment group (MIA+CUR-loaded PLGA NPs) that received IAIs of CUR-loaded PLGA NPs (200 mg/kg b...
2022: Mediators of Inflammation
https://read.qxmd.com/read/36452628/in-silico-analysis-and-comparative-molecular-docking-study-of-fda-approved-drugs-with-transforming-growth-factor-beta-receptors-in-oral-submucous-fibrosis
#26
JOURNAL ARTICLE
Arpita Rai, Sahar Qazi, Khalid Raza
Oral sub-mucous fibrosis (OSMF) is a severe crippling malignant disorder which affects the oral mucosa. The transforming growth factor beta (TGF-β) is one of the cytokines involved with the cell proliferation, cell growth and apoptosis. Several traditional and synthetic medications have been tried in OSMF. This study attempts to identify the FDA approved drugs (including both synthetic and herbal medications) with least side effects, highest efficacy and robust dynamic mechanism for the treatment of OSMF...
October 2022: Indian Journal of Otolaryngology and Head and Neck Surgery
https://read.qxmd.com/read/36382656/inhibition-of-colorectal-cancer-tumorigenesis-by-ursolic-acid-and-doxorubicin-is-mediated-by-targeting-the-akt-signaling-pathway-and-activating-the-hippo-signaling-pathway
#27
JOURNAL ARTICLE
Dan Hu, Ruo Yu Meng, Thi Van Nguyen, Ok Hee Chai, Byung Hyun Park, Ju-Seog Lee, Soo Mi Kim
Colorectal cancer (CRC) is one of the deadliest malignant tumors worldwide and its prevalence is increasing in South Korea. The efficacy of combined treatment with natural product‑derived and chemotherapy agents including curcumin combined with 5‑fluorouracil, resveratrol combined with cisplatin and epigallocatechin‑3‑gallate (EGCG) combined with cisplatin in preventing cancer progression and killing cancer cells has emerged. The Akt and Hippo signaling pathways serve a key role in colorectal tumor growth; however, the exact role of the crosstalk between Akt and Hippo signaling pathways in CRC remains poorly elucidated...
January 2023: Molecular Medicine Reports
https://read.qxmd.com/read/36361729/in-silico-and-in-vitro-studies-of-benzothiazole-isothioureas-derivatives-as-a-multitarget-compound-for-alzheimer-s-disease
#28
JOURNAL ARTICLE
Martha Cecilia Rosales Hernández, Leticia Guadalupe Fragoso Morales, José Correa Basurto, Marycruz Olvera Valdez, Efrén Venancio García Báez, Dania Guadalupe Román Vázquez, Ana Paola Anaya García, Alejandro Cruz
Alzheimer's disease (AD) is a progressive neurodegenerative disorder. Inhibiting acetylcholinesterase (AChE), amyloid beta (Aβ1-42 ) aggregation and avoiding the oxidative stress could prevent the progression of AD. Benzothiazole groups have shown neuroprotective activity whereas isothioureas groups act as AChE inhibitors and antioxidants. Therefore, 22 benzothiazole-isothiourea derivatives ( 3a - v ) were evaluated by docking simulations as inhibitors of AChE and Aβ1-42 aggregation. In silico studies showed that 3f , 3r and 3t had a delta G (ΔG) value better than curcumin and galantamine on Aβ1-42 and AChE, respectively...
October 26, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/36323008/geotrichum-candidum-arthrospore-cell-wall-particles-as-a-novel-carrier-for-curcumin-encapsulation
#29
JOURNAL ARTICLE
Yueran Wu, Xiangnan Wang, Zhenzhen Yin, Jiajia Dong
We report for the first time that curcumin is successfully encapsulated into a new natural pre-formed carrier, which was derived from arthrospore cell wall particles (APs) of probiotic Geotrichum candidum LG-8 and mainly composed of beta-1,4-glucan. Vacuum infusion process was used for efficient encapsulation of curcumin. The results showed that the encapsulation efficiency and yield of APs were 36.5 ± 0.9 % and 730.6 ± 26.5 μg/g (wet basis), respectively. Compared with the other probiotic carriers such as Saccharomyces cerevisiae, it could more effectively maintain the antioxidant property and storage capacity of curcumin under high temperature conditions...
September 19, 2022: Food Chemistry
https://read.qxmd.com/read/36302234/correlation-of-macrophages-with-inflammatory-reaction-in-ulcerative-colitis-and-influence-of-curcumin-on-macrophage-chemotaxis
#30
JOURNAL ARTICLE
Yalan Chen, Dalei Chen, Chuanhe Zhou, Xiaocang Cao, Juan He
Objective: Our study aimed to elucidate the correlation of macrophage (mø) with the inflammatory reaction in ulcerative colitis (UC) and the influence of curcumin (Cur) on mø chemotaxis in mice with UC. Methods: A total of 49 patients with UC (research group; RG) admitted between June 2020 and October 2021 and 56 healthy individuals (control group; CG) who visited concurrently were selected as the study participants. The peripheral blood mononuclear cells (PBMCs) were analyzed, and M1-type/M2-type mø and inflammatory factors (IFs) interleukin (IL)-1, IL-6, IL-10, tumor necrosis factor alpha (TNF-α) and transforming growth factor beta (TGF-β) were detected...
October 28, 2022: Alternative Therapies in Health and Medicine
https://read.qxmd.com/read/36235189/enhanced-antioxidant-and-anti-inflammatory-effects-of-self-nano-and-microemulsifying-drug-delivery-systems-containing-curcumin
#31
JOURNAL ARTICLE
Liza Józsa, Gábor Vasvári, Dávid Sinka, Dániel Nemes, Zoltan Ujhelyi, Miklós Vecsernyés, Judit Váradi, Ferenc Fenyvesi, István Lekli, Alexandra Gyöngyösi, Ildikó Bácskay, Pálma Fehér
Turmeric has been used for decades for its antioxidant and anti-inflammatory effect, which is due to an active ingredient isolated from the plant, called curcumin. However, the extremely poor water-solubility of curcumin often limits the bioavailability of the drug. The aim of our experimental work was to improve the solubility and thus bioavailability of curcumin by developing self-nano/microemulsifying drug delivery systems (SN/MEDDS). Labrasol and Cremophor RH 40 as nonionic surfactants, Transcutol P as co-surfactant and isopropyl myristate as the oily phase were used during the formulation...
October 6, 2022: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/36076967/curcumin-sensitises-cancerous-kidney-cells-to-trail-induced-apoptosis-via-let-7c-mediated-deregulation-of-cell-cycle-proteins-and-cellular-metabolism
#32
JOURNAL ARTICLE
Ismael Obaidi, Alfonso Blanco Fernández, Tara McMorrow
Targeted therapies are the most attractive options in the treatment of different tumours, including kidney cancers. Such therapies have entered a golden era due to advancements in research, breakthroughs in scientific knowledge, and a better understanding of cancer therapy mechanisms, which significantly improve the survival rates and life expectancy of patients. The use of tumour necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL) as an anticancer therapy has attracted the attention of the scientific community and created great excitement due to its selectivity in targeting cancerous cells with no toxic impacts on normal tissues...
August 24, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/35971926/curcumin-protects-islet-beta-cells-from-streptozotocin%C3%A2-induced-type-2-diabetes-mellitus-injury-via-its-antioxidative-effects
#33
JOURNAL ARTICLE
Jingling Duan, Mingqing Yang, Yi Liu, Shengjun Xiao, Xiaoling Zhang
Streptozotocin (STZ)-induced diabetes rodent models are widely used to study the pathogenesis and metabolic function in diabetes (DM). The aim of this study was to assess the antioxidant effect of curcumin in STZ-induced type 2 diabetes mellitus (T2DM). In this research, rats were randomly divided into 3 groups (8 in each group): a nondiabetic group (Control), a diabetic group (DM), and a curcumin treatment group (DM + Cur 200 mg/kg group). Meanwhile, after intraperitoneal injection (i.p.), associated-oxidative stress parameters were observed, malondialdehyde (MDA) was decreased, and glutathione peroxidase (GPX) and super oxide dismutase (SOD) were restored in pancreatic tissues of curcumin-treated DM rats...
August 16, 2022: Endokrynologia Polska
https://read.qxmd.com/read/35935043/preparation-and-cytotoxic-evaluation-of-pgv-1-derivative-cca-1-1-as-a-new-curcumin-analog-with-improved-physicochemical-and-pharmacological-properties
#34
JOURNAL ARTICLE
Rohmad Yudi Utomo, Febri Wulandari, Dhania Novitasari, Beni Lestari, Ratna Asmah Susidarti, Riris Istighfari Jenie, Jun-Ya Kato, Sardjiman Sardjiman, Edy Meiyanto
Purpose: This study aimed to challenge the anticancer potency of pentagamavunone-1 (PGV- 1) and obtain a new compound (Chemoprevention-Curcumin Analog 1.1, CCA-1.1) with improved chemical and pharmacological properties. Methods: CCA-1.1 was prepared by changing the ketone group of PGV-1 into a hydroxyl group with NaBH4 as the reducing agent. The product was purified under preparative layer chromatography and confirmed with HPLC to show about 93% purity. It was tested for its solubility, stability, and cytotoxic activities on several cancer cells...
May 2022: Advanced Pharmaceutical Bulletin
https://read.qxmd.com/read/35903083/pathobiology-of-the-klotho-antiaging-protein-and-therapeutic-considerations
#35
REVIEW
Gérald J Prud'homme, Mervé Kurt, Qinghua Wang
The α-Klotho protein (henceforth denoted Klotho) has antiaging properties, as first observed in mice homozygous for a hypomorphic Klotho gene ( kl/kl ). These mice have a shortened lifespan, stunted growth, renal disease, hyperphosphatemia, hypercalcemia, vascular calcification, cardiac hypertrophy, hypertension, pulmonary disease, cognitive impairment, multi-organ atrophy and fibrosis. Overexpression of Klotho has opposite effects, extending lifespan. In humans, Klotho levels decline with age, chronic kidney disease, diabetes, Alzheimer's disease and other conditions...
2022: Front Aging
https://read.qxmd.com/read/35889441/antiproliferative-ruthenium-complexes-containing-curcuminoid-ligands-tested-in-vitro-on-human-ovarian-tumor-cell-line-a2780-towards-their-capability-to-modulate-the-nf-%C3%AE%C2%BA-btranscription-factor-fgf-2-growth-factor-and-mmp-9-pathway
#36
JOURNAL ARTICLE
Janka Leskovská, Natalia Miklášová, Paul Milan Kubelac, Patriciu Achimaş-Cadariu, Jindra Valentová, Mário Markuliak, Eva Fischer-Fodor
So far, the polyphenolic components of turmeric have shown a significant pharmacological preventative activity for a wide spectrum of diseases, including oncological disorders. This type of natural product could be of great interest for the inhibition of cancer cell proliferation, displaying less side effects in comparison to classical chemotherapeutics. The poor bioavailability and quick metabolism of such natural compounds require new investigative methods to improve their stability in the organisms. A synthetic approach to increase the efficiency of curcuminoids is to coordinate them to metals through the beta-dicarbonyl moiety...
July 18, 2022: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/35880174/inflammation-in-preeclampsia-genetic-biomarkers-mechanisms-and-therapeutic-strategies
#37
JOURNAL ARTICLE
Yue Wang, Baoxuan Li, Yan Zhao
Objective: Preeclampsia is a common and serious complication of pregnancy, posing a threat to maternal and fetal safety due to the lack of effective biomarkers and treatment strategies. This study aimed to identify potential biomarkers that can be used to predict preeclampsia and identify the molecular mechanisms of preeclampsia pathogenesis and drug prediction at the transcriptome level. Methods: We analyzed differential expression genes (DEGs) in preeclampsia and non-preeclampsia groups in the GSE75010 dataset, cross-linking with extracted inflammatory response-related genes to obtain differentially expressed inflammation-related genes (DINRGs)...
2022: Frontiers in Immunology
https://read.qxmd.com/read/35864969/the-low-density-lipoprotein-receptor-related-protein-6-pathway-in-the-treatment-of-intestinal-barrier-dysfunction-induced-by-hypoxia-and-intestinal-microbiota-through-the-wnt-%C3%AE-catenin-pathway
#38
JOURNAL ARTICLE
Zhihua Liu, Chao Li, Min Liu, Zhen Song, Mary Pat Moyer, Dan Su
Our study is to explore the key molecular of Low-density lipoprotein receptor-related protein 6 (LRP6) and the related Wnt/β-catenin pathway regulated by LRP6 during the intestinal barrier dysfunction. Colorectal protein profile analysis showed that LRP6 expression was decreased in dextran sulfate sodium (DSS)-induced colitis mice, and mice received fecal bacteria transplantation from stroke patients. Mice with intestinal hypoxia and intestinal epithelial cells cultured in hypoxia showed decreased expression of LRP6...
2022: International Journal of Biological Sciences
https://read.qxmd.com/read/35835316/proteomic-alterations-in-paracoccidioides-brasiliensis-caused-by-exposure-to-curcumin
#39
JOURNAL ARTICLE
Olivia Basso Rocha, Kleber Santiago Freitas E Silva, Marcos Antônio Batista de Carvalho Junior, Dayane Moraes, Antônio Alonso, Laís Alonso, Lívia do Carmo Silva, Celia Maria Almeida Soares, Maristela Pereira
Paracoccidioides spp. are the etiological agent of paracoccidioidomycosis, a disease that causes skin lesions and affect the lungs and other organs. The current management of the disease is long and has several side effects that often lead the patient to give up the treatment, sequelae and even death. The search for new forms of treatment that minimize these drawbacks is very important. Thus, natural compounds are targets of great interest. Curcumin is one of the main components of the tubers of Curcuma longa, presenting medicinal effects well described in the literature, including the antifungal effect on Paracocidioides brasiliensis...
August 30, 2022: Journal of Proteomics
https://read.qxmd.com/read/35807694/regulation-of-gene-expression-through-food-curcumin-as-a-sirtuin-activity-modulator
#40
REVIEW
Anca Ungurianu, Anca Zanfirescu, Denisa Margină
The sirtuin family comprises NAD+ -dependent protein lysine deacylases, mammalian sirtuins being either nuclear (SIRT1, SIRT2, SIRT6, and SIRT7), mitochondrial (SIRT3, SIRT4, and SIRT5) or cytosolic enzymes (SIRT2 and SIRT5). They are able to catalyze direct metabolic reactions, thus regulating several physiological functions, such as energy metabolism, stress response, inflammation, cell survival, DNA repair, tissue regeneration, neuronal signaling, and even circadian rhythms. Based on these data, recent research was focused on finding molecules that could regulate sirtuins' expression and/or activity, natural compounds being among the most promising in the field...
June 30, 2022: Plants (Basel, Switzerland)
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