keyword
MENU ▼
Read by QxMD icon Read
search

LGD-4033

keyword
https://www.readbyqxmd.com/read/26044265/characterization-of-a-non-approved-selective-androgen-receptor-modulator-drug-candidate-sold-via-the-internet-and-identification-of-in-vitro-generated-phase-i-metabolites-for-human-sports-drug-testing
#1
Mario Thevis, Andreas Lagojda, Dirk Kuehne, Andreas Thomas, Josef Dib, Annelie Hansson, Mikael Hedeland, Ulf Bondesson, Tina Wigger, Uwe Karst, Wilhelm Schänzer
RATIONALE: Potentially performance-enhancing agents, particularly anabolic agents, are advertised and distributed by Internet-based suppliers to a substantial extent. Among these anabolic agents, a substance referred to as LGD-4033 has been made available, comprising the core structure of a class of selective androgen receptor modulators (SARMs). METHODS: In order to provide comprehensive analytical data for doping controls, the substance was obtained and characterized by nuclear magnetic resonance spectroscopy (NMR) and liquid chromatography/electrospray ionization high resolution/high accuracy tandem mass spectrometry (LC/ESI-HRMS)...
June 15, 2015: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/25168622/identification-of-black-market-products-and-potential-doping-agents-in-germany-2010-2013
#2
Oliver Krug, Andreas Thomas, Katja Walpurgis, Thomas Piper, Gerd Sigmund, Wilhelm Schänzer, Tim Laussmann, Mario Thevis
PURPOSE: The desire to increase the athletic performance, to 'optimize' an individual's appearance, and to complement but also to arguably substitute exercise by means of drugs and drug candidates has generated a considerable (illicit) market for compounds such as anabolic-androgenic steroids, stimulants, growth promoting peptide hormones, and so on. Genuinely developed for therapeutic use, their abuse/misuse generates enormous health risks, which has necessitated comprehensive controls of compound trafficking by customs and anti-doping authorities...
November 2014: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/24189892/selective-androgen-receptor-modulators-for-the-prevention-and-treatment-of-muscle-wasting-associated-with-cancer
#3
REVIEW
James T Dalton, Ryan P Taylor, Michael L Mohler, Mitchell S Steiner
PURPOSE OF REVIEW: This review highlights selective androgen receptor modulators (SARMs) as emerging agents in late-stage clinical development for the prevention and treatment of muscle wasting associated with cancer. RECENT FINDINGS: Muscle wasting, including a loss of skeletal muscle, is a cancer-related symptom that begins early in the progression of cancer and affects a patient's quality of life, ability to tolerate chemotherapy, and survival. SARMs increase muscle mass and improve physical function in healthy and diseased individuals, and potentially may provide a new therapy for muscle wasting and cancer cachexia...
December 2013: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/22459616/the-safety-pharmacokinetics-and-effects-of-lgd-4033-a-novel-nonsteroidal-oral-selective-androgen-receptor-modulator-in-healthy-young-men
#4
RANDOMIZED CONTROLLED TRIAL
Shehzad Basaria, Lauren Collins, E Lichar Dillon, Katie Orwoll, Thomas W Storer, Renee Miciek, Jagadish Ulloor, Anqi Zhang, Richard Eder, Heather Zientek, Gilad Gordon, Syed Kazmi, Melinda Sheffield-Moore, Shalender Bhasin
BACKGROUND: Concerns about potential adverse effects of testosterone on prostate have motivated the development of selective androgen receptor modulators that display tissue-selective activation of androgenic signaling. LGD-4033, a novel nonsteroidal, oral selective androgen receptor modulator, binds androgen receptor with high affinity and selectivity. Objectives. To evaluate the safety, tolerability, pharmacokinetics, and effects of ascending doses of LGD-4033 administered daily for 21 days on lean body mass, muscle strength, stair-climbing power, and sex hormones...
January 2013: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
1
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"