keyword
https://read.qxmd.com/read/38500407/positive-clinical-outcome-using-a-modified-dosing-regimen-of-benznidazole-in-dogs-at-high-risk-for-infection-or-acutely-infected-with-trypanosoma-cruzi
#21
Sukjung Lim, Stephanie Collins, Sarah A Hamer, Rick L Tarleton, Ashley B Saunders
Trypanosoma cruzi infection in dogs can cause heart failure and sudden death with few treatment options available. A litter of 4 dogs living in a T cruzi endemic area were randomized to prophylaxis and nonprophylaxis groups as part of a study evaluating a modified benznidazole dosing regimen administered twice weekly to prevent T cruzi infection during a vector transmission season. The 2 dogs that received prophylaxis remained healthy without T cruzi infection or cardiac disease for >2 years. One dog that did not receive prophylaxis died unexpectedly with acute T cruzi-induced pancarditis, and the second dog tested positive for T cruzi and developed complex arrhythmias with markedly increased cardiac troponin I and improved with a higher benznidazole treatment dose...
March 18, 2024: Journal of Veterinary Internal Medicine
https://read.qxmd.com/read/38500121/relationship-between-genetic-diversity-and-morpho-functional-characteristics-of-flight-related-traits-in-triatoma-garciabesi-hemiptera-reduviidae
#22
JOURNAL ARTICLE
Thaiane Verly, Sebastián Pita, Ana Laura Carbajal-de-la-Fuente, Gabriela Burgueño-Rodríguez, Romina V Piccinali, Federico G Fiad, Néstor Ríos, Francisco Panzera, Patricia Lobbia, Paz Sánchez-Casaccia, Antonieta Rojas de Arias, María José Cavallo, Gisel V Gigena, Claudia S Rodríguez, Julieta Nattero
BACKGROUND: Triatoma garciabesi, a potential vector of the parasitic protozoan Trypanosoma cruzi, which is the causative agent of Chagas disease, is common in peridomestic and wild environments and found throughout northwestern and central Argentina, western Paraguay and the Bolivian Chaco. Genetic differentiation of a species across its range can help to understand dispersal patterns and connectivity between habitats. Dispersal by flight is considered to be the main active dispersal strategy used by triatomines...
March 18, 2024: Parasites & Vectors
https://read.qxmd.com/read/38495541/ecoepidemiology-of-chagas-disease-in-a-biological-corridor-in-southeastern-mexico-a-promising-approach-to-understand-the-risk-of-chagas-disease
#23
JOURNAL ARTICLE
Ingrid Yazmin Cruz-Alegría, Nancy Gabriela Santos-Hernández, Christian Ruiz-Castillejos, Juan Felipe Ruan-Soto, Adriana Moreno-Rodríguez, Any Laura Flores-Villegas, Javier Gutiérrez-Jiménez, Luis Arturo Hernández-Mijangos, Eduardo Estanislao Espinoza-Medinilla, Dolores Guadalupe Vidal-López, José Antonio De Fuentes-Vicente
Ecoepidemiology is an emerging field that attempts to explain how biotic, environmental, and even social factors influence the dynamics of infectious diseases. Particularly in vector-borne diseases, the study under this approach offers us an overview of the pathogens, vectors, and hosts that coexist in a given region and their ecological determinants. As a result of this, risk predictions can be established in a changing environment and how it may impact human populations. This paper is aimed at evaluating some ecoepidemiological characteristics of Chagas disease in a natural reserve in southeastern Mexico that borders human settlements...
2024: Journal of Parasitology Research
https://read.qxmd.com/read/38490011/positional-vertigo-%C3%A2-beyond-benign-paroxysmal-positional-vertigo-case-report
#24
Lucas Scatolin Partezani, Raquel Mezzalira, Luis Augusto Guedes de Mello Dias, Daniela Akemi Souza Saito, Marina Saes Rays, Durval de Paula Chagas Neto
No abstract text is available yet for this article.
February 21, 2024: Brazilian Journal of Otorhinolaryngology
https://read.qxmd.com/read/38489395/comparative-evaluation-of-four-rapid-diagnostic-tests-that-detect-human-trypanosoma-cruzi-specific-antibodies-to-support-diagnosis-of-chagas-disease-in-urban-population-of-argentina
#25
JOURNAL ARTICLE
Rocío Rivero, M Soledad Santini, Constanza López-Albizu, Marcelo Rodriguez, Adriana Calbosa, Daniela Oliveto, Mónica Esteva, Margarita Bisio, Laura C Bohorquez
BACKGROUND: Chagas disease (CD), caused by the parasite Trypanosoma cruzi, is the most important endemic anthropozoonosis in Argentina. Since 2010, the World Health Organization has highlighted the urgent need to validate diagnostic systems that allow rapid detection of T. cruzi, infection in primary healthcare centers. Serological rapid diagnostic tests (RDTs) for T. cruzi, infection could be used to improve case management, as RDTs do not require specialized laboratories or highly trained staff to use them...
March 15, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38485084/a-systematic-review-and-meta-analysis-of-mortality-in-chronic-chagas-cardiomyopathy-versus-other-cardiomyopathies-higher-risk-or-fiction
#26
JOURNAL ARTICLE
Sergio A Gómez-Ochoa, Angie Yarlady Serrano-García, Alexandra Hurtado-Ortiz, Andrea Aceros, Lyda Z Rojas, Luis E Echeverría
INTRODUCTION AND OBJECTIVES: Although multiple studies suggest that chronic Chagas cardiomyopathy (CCC) has higher mortality than other cardiomyopathies, the absence of meta-analyses supporting this perspective limits the possibility of generating robust conclusions. The aim of this study was to systematically evaluate the current evidence on mortality risk in CCC compared with that of other cardiomyopathies. METHODS: PubMed/Medline and EMBASE were searched for studies comparing mortality risk between patients with CCC and those with other cardiomyopathies, including in the latter nonischemic cardiomyopathy (NICM), ischemic cardiomyopathy, and non-Chagas cardiomyopathy (nonCC)...
March 12, 2024: Revista Española de Cardiología
https://read.qxmd.com/read/38484645/acrylonitrile-derivatives-in-vitro-activity-and-mechanism-of-cell-death-induction-against-trypanosoma-cruzi-and-leishmania-amazonensis
#27
JOURNAL ARTICLE
Carlos J Bethencourt-Estrella, Samuel Delgado-Hernández, Atteneri López-Arencibia, Desirée San Nicolás-Hernández, Lizbeth Salazar-Villatoro, Maritza Omaña-Molina, David Tejedor, Fernando García-Tellado, Jacob Lorenzo-Morales, José E Piñero
Leishmaniasis and Chagas disease are parasitic infections that affect millions of people worldwide, producing thousands of deaths per year. The current treatments against these pathologies are not totally effective and produce some side effects in the patients. Acrylonitrile derivatives are a group of compounds that have shown activity against these two diseases. In this work, four novels synthetic acrylonitriles were evaluated against the intracellular form and extracellular forms of L. amazonensis and T. cruzi...
March 6, 2024: International Journal for Parasitology, Drugs and Drug Resistance
https://read.qxmd.com/read/38483055/if-not-angioedema-what-is-it-diagnostic-approach-to-facial-edema
#28
REVIEW
Juan Pablo Velasco-Amador, Álvaro Prados-Carmona, Francisco José Navarro-Triviño
Facial edema is a relatively frequent clinical presentation encountered in patients seen in allergology and dermatology clinics. The differential diagnosis is broad, and sometimes the definitive diagnosis can be a challenge for the clinician. Facial angioedema itself encompasses different etiopathologies (histaminergic, bradykinergic, etc.) that must be distinguished from other causes of facial edema, such as allergic contact dermatitis, granulomatous conditions, inflammatory causes, infections, neoplasms or paraneoplastic syndromes, autoimmune diseases, among other entities hereby referred as miscellanea...
March 14, 2024: Journal der Deutschen Dermatologischen Gesellschaft: JDDG
https://read.qxmd.com/read/38481660/vaccination-with-parasite-specific-tctasv-proteins-combined-with-recombinant-baculovirus-as-a-delivery-platform-protects-against-acute-and-chronic-trypanosoma-cruzi-infection
#29
JOURNAL ARTICLE
Yamil E Masip, Lucas D Caeiro, Maximiliano Cosenza, Miriam Postan, Guido Molina, Oscar Taboga, María Paula Molinari, Valeria Tekiel
Chagas' is a neglected disease caused by the eukaryotic kinetoplastid parasite, Trypanosoma cruzi. Currently, approximately 8 million people are infected worldwide, most of whom are in the chronic phase of the disease, which involves cardiac, digestive, or neurologic manifestations. There is an urgent need for a vaccine because treatments are only effective in the initial phase of infection, which is generally underdiagnosed. The selection and combination of antigens, adjuvants, and delivery platforms for vaccine formulations should be designed to trigger mixed humoral and cellular immune responses, considering that T...
2024: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/38476951/evaluating-the-diagnostic-accuracy-of-tpn17-and-tmpa-recombinant-proteins-in-syphilis-detection-a-phase-ii-study
#30
JOURNAL ARTICLE
Ângelo Antônio Oliveira Silva, Ayla Araújo Lima, Larissa Carvalho Medrado Vasconcelos, Rosângela Andrade Almeida, Natália Erdens Maron Freitas, Talita Andrade Oliva, Miralba Freire de Carvalho Ribeiro da Silva, Fabricio Klerynton Marchini, Nilson Ivo Tonin Zanchin, Isadora Cristina de Siqueira, Fred Luciano Neves Santos
Syphilis is a sexually transmitted infection (STI) caused by the spiral bacterium Treponema pallidum . Diagnosis is based on epidemiology, clinical and serology, but serodiagnosis is challenging because distinct clinical forms of the infection may influence serological performance. Several recombinant Treponema pallidum -proteins have already been tested for syphilis diagnosis and they are critical to achieve high accuracy in serological testing. A total of 647 samples were included in the study: 180 T. pallidum -positive samples, 191 T...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38476306/endoscopic-submucosal-dissection-for-resections-larger-than-10-cm-outcomes-from-a-portuguese-center
#31
JOURNAL ARTICLE
Raquel R Mendes, Pedro Barreiro, André Mascarenhas, Ana Rita Franco, Liliana Carvalho, Cristina Chagas
BACKGROUND: Endoscopic submucosal dissection (ESD) is a minimally invasive technique for en bloc resection of superficial neoplastic lesions, independent of their size. However, for giant gastrointestinal superficial neoplasia, the risk of invasive cancer is higher, and ESD is typically challenging. Despite the increasing literature on giant resections, data on their efficacy and safety are still lacking. OBJECTIVE: The aim of this study was to describe ESD outcomes from a Portuguese center, compare them with other international studies, and analyze the possible risk factors influencing outcomes...
February 2024: GE Portuguese Journal of Gastroenterology
https://read.qxmd.com/read/38472341/techniques-for-registration-of-myoelectric-activity-of-women-s-pelvic-floor-muscles-a-scoping-review
#32
REVIEW
Josepha Karinne de Oliveira Ferro, Andrea Lemos, Alessandra Carolina de Santana Chagas, Alexa Alves de Moraes, Ana Izabela Sobral de Oliveira-Souza, Daniella Araújo de Oliveira
INTRODUCTION AND HYPOTHESIS: Surface electromyography is commonly applied to measure the electrophysiological activity of the neuromuscular system. However, there is no consensus regarding the best protocol to assess pelvic floor muscles. METHODS: A scoping literature review was carried out in six databases, using MeSH descriptors. It included studies with electromyographic assessment in adult women presenting or not with pelvic floor dysfunction. The results were presented in categories to contribute to the development of a protocol considering the most used parameters for non-invasive assessment of myoelectric activity of pelvic floor muscles...
March 12, 2024: International Urogynecology Journal
https://read.qxmd.com/read/38467231/imported-infectious-diseases-in-migrants-from-latin-america-a-retrospective-study-from-a-referral-centre-for-tropical-diseases-in-spain-2017-2022
#33
JOURNAL ARTICLE
Marta Arsuaga, Rosa De Miguel Buckley, Fernando De La Calle-Prieto, Marta Díaz-Menéndez
INTRODUCTION: Detecting imported diseases by migrants and individuals visiting friends and relatives (VFR) is key in the prevention and management of emergent infectious diseases acquired abroad. METHODS: Retrospective descriptive study on migrants and VFR from Central and South America between 2017 and 2022 attended at a National Referral Centre for Tropical Diseases in Madrid, Spain. Demographic characteristics, syndromes and confirmed travel-related diagnoses were obtained from hospital patient medical records...
March 9, 2024: Travel Medicine and Infectious Disease
https://read.qxmd.com/read/38467078/-seroprevalence-of-chagas-disease-at-the-instituto-nacional-de-cardiolog%C3%A3-a-ignacio-ch%C3%A3-vez-from-2004-to-2010
#34
JOURNAL ARTICLE
Diana V Reséndiz-Solís, Alejandro Ruiz-Sánchez, Martha A Ballinas-Verdugo
BACKGROUND: Different pathogens can cause dilated cardiomyopathy, one of them is Trypanosoma cruzi protozoan. T.cruzi-chronic infection causes chronic Chagasic cardiomyopathy and affects the sinus node and the conduction systembelow the bundle of His; besides, it shows excellent arrhythmogenic potential because of ventricular arrhythmias. Knowingthe clinical characteristics and performing serological tests to diagnose chronic Chagasic cardiomyopathy is essential. The serological diagnosis for searching the antibodies is based on the phase, which can be a predictor for the development of dilated cardiomyopathy...
March 11, 2024: Archivos de Cardiología de México
https://read.qxmd.com/read/38462304/trypanosoma-cruzi-antibody-screening-in-north-texas-client-owned-dogs
#35
JOURNAL ARTICLE
Wendy Pace, Joseph Oppong
Despite multiple screening efforts to identify exposures to Trypanosoma cruzi, in dogs across southern USA, no published studies could be found involving client owned dogs in the North Texas Metroplex area. Therefore, a limited screen was conducted for client owned dogs, seeking routine or preventative care, from participating veterinary practices in the greater Dallas-Fort Worth (DFW) Metroplex from 2019 to 2021. Participants, with owner consent, ranged in age, breed, and length of time at recorded residence...
April 2024: Veterinary Parasitology (Amsterdam)
https://read.qxmd.com/read/38461045/influence-of-temperature-variability-on-the-feeding-behavior-and-blood-consumption-of-triatoma-infestans-hemiptera-reduviidae
#36
JOURNAL ARTICLE
Bárbara Álvarez-Duhart, Grisel Cavieres, Avia González, Pedro E Cattan, Francisco Bozinovic, Sabrina Clavijo-Baquet
The transmission and incidence of vector-borne diseases rely on vector distribution and life history traits such as survival, fecundity, and feeding. Since arthropod disease vectors are ectotherms, these vital rates are strongly influenced by temperature. Chagas disease is a neglected tropical disease caused by the protozoan parasite, Trypanosoma cruzi. This parasite is transmitted when the feces of the infected triatomine enter the bloodstream of the host. One of the most important vector-species of this disease in the Southern Cone region of South America is Triatoma infestans...
March 10, 2024: Journal of Medical Entomology
https://read.qxmd.com/read/38459811/epstein-barr-virus-associated-colitis-in-kidney-transplant-patients-a-case-series
#37
JOURNAL ARTICLE
Ana Catarina Brás, Sara Querido, André Mascarenhas, Raquel Mendes, Rita Verissimo, Cristina Chagas, André Weigert
BACKGROUND: Gastrointestinal complications are common in kidney transplant (KT) patients and can be a consequence of the chronic use of immunosuppression. The differential diagnosis of colitis in KT patients includes intolerance to immunosuppressive agents, namely mycophenolate mofetil, de novo inflammatory bowel disease (IBD) and opportunistic infections. Epstein-Barr virus (EBV) infection may cause post-transplant colitis or trigger de novo IBD, although is seldom thought as the causative pathogen...
March 9, 2024: Infectious Diseases
https://read.qxmd.com/read/38457443/small-molecule-mediators-of-host-t-cruzi-environment-interactions-in-chagas-disease
#38
REVIEW
Godwin Kwakye-Nuako, Caitlyn E Middleton, Laura-Isobel McCall
Small molecules (less than 1,500 Da) include major biological signals that mediate host-pathogen-microbiome communication. They also include key intermediates of metabolism and critical cellular building blocks. Pathogens present with unique nutritional needs that restrict pathogen colonization or promote tissue damage. In parallel, parts of host metabolism are responsive to immune signaling and regulated by immune cascades. These interactions can trigger both adaptive and maladaptive metabolic changes in the host, with microbiome-derived signals also contributing to disease progression...
March 2024: PLoS Pathogens
https://read.qxmd.com/read/38452392/prevalence-of-maternal-chagas-disease-and-vertical-transmission-rates-in-bolivia-a-systematic-review-and-meta-analysis
#39
JOURNAL ARTICLE
Freddy Tinajeros, Beatriz Amparo Rodríguez-Olguin, Melissa Klein Cutshaw
Bolivia has one of the highest burdens of Chagas disease in the world. Vertical transmission from mother to infant accounts for a growing number of cases. We performed a systematic review of articles assessing the prevalence of Chagas disease in pregnant women and rates of vertical transmission to infants in Bolivia. Studies were not excluded based on year of publication or language. Random-effects analyses were performed to estimate a pooled prevalence of maternal Chagas disease and pooled vertical transmission rate...
March 5, 2024: American Journal of Tropical Medicine and Hygiene
https://read.qxmd.com/read/38448494/high-throughput-analysis-of-the-trypanosoma-cruzi-minicirculome-mcdna-unveils-structural-variation-and-functional-diversity
#40
JOURNAL ARTICLE
Andrés Gómez-Palacio, Lissa Cruz-Saavedra, Frederik Van den Broeck, Manon Geerts, Sebastián Pita, Gustavo A Vallejo, Julio C Carranza, Juan David Ramírez
Trypanosoma cruzi causes Chagas disease and has a unique extranuclear genome enclosed in a structure called the kinetoplast, which contains circular genomes known as maxi- and minicircles. While the structure and function of maxicircles are well-understood, many aspects of minicircles remain to be discovered. Here, we performed a high-throughput analysis of the minicirculome (mcDNA) in 50 clones isolated from Colombia's diverse T. cruzi I populations. Results indicate that mcDNA comprises four diverse subpopulations with different structures, lengths, and numbers of interspersed semi-conserved (previously termed ultra-conserved regions mHCV) and hypervariable (mHVPs) regions...
March 7, 2024: Scientific Reports
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