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https://www.readbyqxmd.com/read/28936735/dual-behavior-of-exosomes-in-septic-cardiomyopathy
#1
Valter Vinícius Silva Monteiro, Jordano Ferreira Reis, Rafaelli de Souza Gomes, Kely Campos Navegantes, Marta Chagas Monteiro
Sepsis is one of the main causes of ICU hospitalization worldwide, with a high mortality rate, and is associated with a large number of comorbidities. One of the main comorbidities associated with sepsis is septic cardiomyopathy. This process occurs mainly due to mechanisms of damage in the cardiovascular system that will lead to changes in cardiovascular physiology, such as decreased Ca(2+) response, mitochondrial dysfunction and decreased β-adrenergic receptor response. Within this process the exosomes play an important role in the pathophysiology of this disease, in which the exosomal content is related to mechanisms that will trigger its development...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28935948/novel-scaffolds-for-inhibition-of-cruzipain-identified-from-high-throughput-screening-of-anti-kinetoplastid-chemical-boxes
#2
Emir Salas-Sarduy, Lionel Urán Landaburu, Joel X Karpiak, Kevin P Madauss, Juan José Cazzulo, Fernán Agüero, Vanina Eder Alvarez
American Trypanosomiasis or Chagas disease is a prevalent, neglected and serious debilitating illness caused by the kinetoplastid protozoan parasite Trypanosoma cruzi. The current chemotherapy is limited only to nifurtimox and benznidazole, two drugs that have poor efficacy in the chronic phase and are rather toxic. In this scenario, more efficacious and safer drugs, preferentially acting through a different mechanism of action and directed against novel targets, are particularly welcome. Cruzipain, the main papain-like cysteine peptidase of T...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28931128/6-year-review-of-redivi-a-prospective-registry-of-imported-infectious-diseases-in-spain
#3
José A Pérez-Molina, Ana López-Polín, Begoña Treviño, Israel Molina, Josune Goikoetxea, Marta Díaz-Menéndez, Diego Torrús, Eva Calabuig, Agustín Benito, Rogelio López-Vélez
Background: Understanding and detecting imported diseases is a priority in the prevention and management of prevalent and emergent infectious diseases acquired abroad. The +Redivi network measures the burden of imported infections in Spain and is essential for closing the gap in travel medicine. Methods: Demographic characteristics, travel information, syndromes and confirmed travel-related diagnoses were registered in a standardised online database. Results: A total of 10 767 cases of imported infectious diseases were registered between October 2009 and December 2015...
September 1, 2017: Journal of Travel Medicine
https://www.readbyqxmd.com/read/28930276/essential-oil-of-cymbopogon-citratus-on-the-control-of-the-curvularia-leaf-spot-disease-on-maize
#4
Dalmarcia de Sousa Carlos Mourão, Talita Ferreira de Souza Pereira, Danival José de Souza, Aloísio Freitas Chagas Júnior, Mateus Sunti Dalcin, Ronice Alves Veloso, Evelynne Urzêdo Leão, Gil Rodrigues Dos Santos
The Curvularia Leaf Spot is becoming more common due to the culture expansion and the low resistance of the cultivated genotypes in tropical regions. Thus, the objective was to evaluate the fungitoxicity of the essential oil of Cymbopogon citratus upon the phytopathogen Curvularia lunata, causative agent of the Curvularia Leaf Spot. There was realized pathogenicity tests of C. lunata in maize plants, phytotoxicity of the essential oil of C. citratus and gas chromatography attached, germination tests of the conidia, and of in vitro inhibition of C...
August 20, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28929112/imaging-diagnosis-of-right-ventricle-involvement-in-chagas-cardiomyopathy
#5
REVIEW
Minna M D Romano, Henrique T Moreira, André Schmidt, Benedito Carlos Maciel, José Antônio Marin-Neto
Right ventricle (RV) is considered a neglected chamber in cardiology and knowledge about its role in cardiac function was mostly focused on ventricular interdependence. However, progress on the understanding of myocardium diseases primarily involving the RV led to a better comprehension of its role in health and disease. In Chagas disease (CD), there is direct evidence from both basic and clinical research of profound structural RV abnormalities. However, clinical detection of these abnormalities is hindered by technical limitations of imaging diagnostic tools...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28926763/synthesis-and-2d-qsar-studies-of-neolignan-based-diaryl-tetrahydrofuran-and-furan-analogues-with-remarkable-activity-against-trypanosoma-cruzi-and-assessment-of-the-trypanothione-reductase-activity
#6
Ana Paula Hartmann, Marcelo Rodrigues de Carvalho, Lilian Sibelle Campos Bernardes, Milena Hoehr de Moraes, Eduardo Borges de Melo, Carla Duque Lopes, Mario Steindel, João Santana da Silva, Ivone Carvalho
Two series of diaryl-tetrahydrofuran and -furan were synthesised and screened for anti-trypanosomal activity against trypomastigote and amastigote forms of Trypanosoma cruzi, the causative agent of Chagas disease. Based on evidence that modification of a natural product may result in a more effective drug than the natural product itself, and using known neolignan inhibitors veraguensin 1 and grandisin 2 as templates to synthesise simpler analogues, remarkable anti-trypanosomal activity and selectivity were found for 3,5-dimethoxylated diaryl-furan 5c and 2,4-dimethoxylated diaryl-tetrahydrofuran 4e analogues with EC50 0...
September 4, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28924201/discovery-semisynthesis-antiparasitic-and-cytotoxic-evaluation-of-14-membered-resorcylic-acid-lactones-and-their-derivatives
#7
Xue-Qing Zhang, Carmenza Spadafora, Laura M Pineda, Michelle G Ng, Ji-Hong Sun, Wei Wang, Chang-Yun Wang, Yu-Cheng Gu, Chang-Lun Shao
Ten antifouling 14-membered resorcylic acid lactones 1-10 were isolated previously with low or trace natural abundance from the zoanthid-derived Cochliobolus lunatus fungus. Further optimization of fermentation conditions led to the isolation of two major natural compounds 7 and 8 with multi-gram quantities. By one or two steps, we semisynthesized the six trace natural compounds 1-6 and a series of derivatives 11-27 of compounds 7 and 8 with high yields (65-95%). Compounds 11-13 showed strong antiplasmodial activity against Plasmodium falciparum with IC50 values of 1...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28923601/beneficial-immunomodulatory-and-neuro-digestive-effect-in-trypanosoma-cruzi-infection-after-lycopodium-clavatum-13c-treatment
#8
Camila Fernanda Brustolin Aleixo, Fabiana Nabarro Ferraz, Paula Fernanda Massini, Carina Ribeiro Lopes, Gislaine Janaina Falkowski Temporini, Denise Lessa Aleixo, Silvana Marques de Araújo
Studies show that highly diluted medications demonstrate benefits in treating infections, constituting an alternative for their treatment. The present study evaluated the effects of Lycopodium clavatum, dynamization 13c, in Wistar rats infected with T. cruzi. In this study 42 male rats were intraperitoneally inoculated with T. cruzi - Y strain and allocated into groups: IC (infected control group) and Ly (treated with L. clavatum 13c). The cytokines dosage (IFN-γ, IL-12, IL-10, IL-4), quantification and morphometry of myenteric neurons were evaluated...
September 15, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28917755/identification-of-trypanosomatids-by-detecting-single-nucleotide-fingerprints-using-dna-analysis-by-dynamic-chemistry-with-maldi-tof
#9
María Angélica Luque-González, Mavys Tabraue-Chávez, Bárbara López-Longarela, Rosario María Sánchez-Martín, Matilde Ortiz-González, Miguel Soriano-Rodríguez, José Antonio García-Salcedo, Salvatore Pernagallo, Juan José Díaz-Mochón
Protozoan parasites of the Trypanosomatidae family can cause devastating diseases in humans and animals, such as Human African Trypanosomiasis or Sleeping Sickness, Chagas disease and Leishmaniasis. Currently, there are molecular assays for detecting parasitic infections and their post-treatment monitoring based on nucleic acid amplification, but there are still certain limitations which limit the development of assays that can detect and discriminate between parasite infections with a single test. Here, we present the development of a novel molecular assay for the rapid identification of Trypanosomatids, integrating DNA analysis by dynamic chemistry in conjunction with Matrix-Assisted Laser Desorption Ionization - Time-of-Flight Mass Spectrometry (MALDI-ToF)...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28915432/new-uses-for-old-complexes-the-very-first-report-on-the-trypanocidal-activity-of-symmetric-trinuclear-ruthenium-complexes
#10
Bruna Possato, Zumira Aparecida Carneiro, Sérgio de Albuquerque, Sofia Nikolaou
This work reports on the trypanocidal activity of a series of symmetric triruthenium complexes combined with azanaphthalene ligands of general formula [Ru3O(CH3COO)6(L)3]PF6 (L=(1) quinazoline (qui), (2) 5-nitroisoquinoline (5-nitroiq), (3) 5-bromoisoquinoline (5-briq), (4) isoquinoline (iq), (5) 5-aminoisoquinoline (5-amiq), and (6) 5,6,7,8-tetrahydroisoquinoline (thiq)). All complexes within the series presented in vitro trypanocidal activity against both the trypomastigote and amastigote forms of T. cruzi...
August 31, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28912986/transmission-of-donor-derived-trypanosoma-cruzi-and-subsequent-development-of-chagas-disease-in-a-lung-transplant-recipient
#11
A B Corey, D Sonetti, J D Maloney, S P Montgomery, B L Rademacher, L J Taylor, J A Smith, R Striker
Donor infection status should be considered when accepting an organ for transplant. Here we present a case of Chagas disease developing after a lung transplant where the donor was known to be Trypanosoma cruzi antibody positive. The recipient developed acute Trypanosoma cruzi infection with reactivation after treatment. Chagas disease-positive donors are likely to be encountered in the United States; donor targeted screening is needed to guide decisions regarding organ transplant and posttransplant monitoring...
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/28912906/constipation-is-related-to-small-bowel-disturbance-rather-than-colonic-enlargement-in-acquired-chagasic-megacolon
#12
Mauro Bafutto, Alejandro Ostermayer Luquetti, Salustiano Gabriel Neto, Felix Andre Sanches Penhavel, Enio Chaves Oliveira
BACKGROUND: Constipation is the main symptom of acquired chagasic megacolon. However, a number of patients with Chagas disease without colon involvement also have the same complain. This study evaluated the role of small bowel in constipated patients with Chagas disease with and without megacolon. METHODS: Orocecal transit time (OCTT) and oral glucose tolerance test (OGTT) in constipated non-chagasic and chagasic patients with and without megacolon were performed...
August 2017: Gastroenterology Research
https://www.readbyqxmd.com/read/28912184/inflammatory-cardiomyopathic-syndromes
#13
REVIEW
Barry H Trachtenberg, Joshua M Hare
Inflammatory activation occurs in nearly all forms of myocardial injury. In contrast, inflammatory cardiomyopathies refer to a diverse group of disorders in which inflammation of the heart (or myocarditis) is the proximate cause of myocardial dysfunction, causing injury that can range from a fully recoverable syndrome to one that leads to chronic remodeling and dilated cardiomyopathy. The most common cause of inflammatory cardiomyopathies in developed countries is lymphocytic myocarditis most commonly caused by a viral pathogenesis...
September 15, 2017: Circulation Research
https://www.readbyqxmd.com/read/28911515/chronic-chagas-heart-disease%C3%A2-management-from-etiology-to-cardiomyopathy-treatment
#14
REVIEW
Edimar Alcides Bocchi, Reinaldo Bulgarelli Bestetti, Mauricio Ibrahim Scanavacca, Edecio Cunha Neto, Victor Sarli Issa
Trypanosoma cruzi (T. cruzi) infection is endemic in Latin America and is becoming a worldwide health burden. It may lead to heterogeneous phenotypes. Early diagnosis of T. cruzi infection is crucial. Several biomarkers have been reported in Chagas heart disease (ChHD), but most are nonspecific for T. cruzi infection. Prognosis of ChHD patients is worse compared with other etiologies, with sudden cardiac death as an important mode of death. Most ChHD patients display diffuse myocarditis with fibrosis and hypertrophy...
September 19, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28910663/strategies-for-overcoming-tropical-disease-by-ruthenium-complexes-with-purine-analog-application-against-leishmania-spp-and-trypanosoma-cruzi
#15
Marzena Fandzloch, José Manuel Méndez Arriaga, Manuel Sánchez-Moreno, Andrzej Wojtczak, Julia Jezierska, Jerzy Sitkowski, Joanna Wiśniewska, Juan Manuel Salas, Iwona Łakomska
Tropical diseases currently constitute a major health problem and thus a challenge in the field of drug discovery. The current treatments show serious disadvantages due to cost, toxicity, long therapy duration and resistance, and the use of metal complexes as chemotherapeutic agents against these ailments appears to be a very attractive alternative. Herein, we describe three newly synthesized ruthenium complexes with a bioactive molecule, the purine analogue 5,6,7-trimethyl-1,2,4-triazolo[1,5-a]pyrimidine (tmtp): cis,fac-[RuCl2(dmso)3(tmtp)] (1), mer-[RuCl3(dmso)(H2O)(tmtp)]·2H2O (2) and fac,cis-[RuCl3(H2O)(tmtp)2] (3)...
September 1, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28910299/access-to-benznidazole-for-chagas-disease-in-the-united-states-cautious-optimism
#16
Jonathan D Alpern, Rogelio Lopez-Velez, William M Stauffer
Drugs for neglected tropical diseases (NTD) are being excessively priced in the United States. Benznidazole, the first-line drug for Chagas disease, may become approved by the Food and Drug Administration (FDA) and manufactured by a private company in the US, thus placing it at risk of similar pricing. Chagas disease is an NTD caused by Trypanosoma cruzi; it is endemic to Latin America, infecting 8 million individuals. Human migration has changed the epidemiology causing nonendemic countries to face increased challenges in diagnosing and managing patients with Chagas disease...
September 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28905716/lack-of-trypanosoma-cruzi-infection-in-urban-roof-rats-rattus-rattus-at-a-texas-facility-housing-naturally-infected-nonhuman-primates
#17
Carolyn L Hodo, Nicole R Bertolini, John C Bernal, John L VandeBerg, Sarah A Hamer
The protozoan parasite Trypanosoma cruzi causes Chagas disease, uses kissing bugs as a vector, and is maintained in nature by a variety of wildlife reservoirs. Many natural cases of Chagas disease have been reported in NHP at facilities across the southern United States, where infected vectors and wildlife occur. Infection of NHP with T. cruzi can diminish their value as research models and lead to health problems and death. Identifying the modes of transmission and role of wildlife reservoirs in these facilities is therefore critical to guide interventions to reduce transmission...
January 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28902285/dipyridamole-potentiated-the-trypanocidal-effect-of-nifurtimox-and-improved-the-cardiac-function-in-nmri-mice-with-acute-chagasic-myocarditis
#18
Sonia Santeliz, Peter Caicedo, Elidiosmar Giraldo, Carmen Alvarez, María-Daniela Yustiz, Claudina Rodríguez-Bonfante, Romina Bonfante-Rodríguez, Rafael Bonfante-Cabarcas
BACKGROUND: As chronic Chagas disease does not have a definitive treatment, the development of alternative therapeutic protocols is a priority. Dipyridamole (DPY) is an alternative to counteract the pathophysiological phenomena involved in Chagas cardiomyopathy. OBJECTIVE: To evaluate the therapeutic efficacy of DPY associated with nifurtimox (Nfx) in epimastigote axenic cultures and in mice with acute Chagas disease. METHODS: NMRI adult male mice were divided into nine groups: three healthy and six Trypanosoma cruzi-infected groups...
September 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28900547/chagas-cardiomyopathy-presenting-as-symptomatic-bradycardia-an-underappreciated-emerging-public-health-problem-in-the-united-states
#19
Richard Jesse Durrance, Tofura Ullah, Zulekha Atif, William Frumkin, Kaushik Doshi
Chagas cardiomyopathy (CCM) is traditionally considered a disease restricted to areas of endemicity. However, an estimated 300,000 people living in the United States today have CCM, of which its majority is undiagnosed. We present a case of CCM acquired in an endemic area and detected in its early stage. A 42-year-old El Salvadoran woman presented with recurrent chest pain and syncopal episodes. Significant family history includes a sister in El Salvador who also began suffering similar episodes. Physical exam and ancillary studies were only remarkable for sinus bradycardia...
2017: Case Reports in Cardiology
https://www.readbyqxmd.com/read/28895736/inp-nanowire-biosensor-with-tailored-biofunctionalization-ultrasensitive-and-highly-selective-disease-biomarker-detection
#20
Richard Janissen, Prasana K Sahoo, Clelton A Santos, Aldeliane M da Silva, Antonio A G von Zuben, Denio E P Souto, Alexandre D T Costa, Paola Celedon, Nilson I T Zanchin, Diogo B Almeida, Douglas S Oliveira, Lauro T Kubota, Carlos Lenz Cesar, Anete Pereira de Souza, Monica Alonso Cotta
Electrically active field-effect transistors (FET) based biosensors are of paramount importance in life science applications, as they offer direct, fast, and highly sensitive label-free detection capabilities of several biomolecules of specific interest. In this work, we report a detailed investigation on surface functionalization and covalent immobilization of biomarkers using biocompatible ethanolamine and poly(ethylene glycol) derivate coatings - as compared to the conventional approaches using silica monoliths - in order to substantially increase both the sensitivity and molecular selectivity of nanowire-based FET biosensor platforms...
September 12, 2017: Nano Letters
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