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Urinary sodium potassium ratio

Rhoda N Ndanuko, Linda C Tapsell, Karen E Charlton, Elizabeth P Neale, Katrina M O'Donnell, Marijka J Batterham
OBJECTIVE: The aim of this study was to examine the relationship between sodium and potassium intakes and blood pressure (BP) in a clinical sample. METHODS: Secondary analysis of baseline data from 328 participants (mean age: 43.6 ± 8 y, mean body mass index [BMI]: 32.4 ± 4.2 kg/m(2), mean systolic BP [SBP]/diastolic BP [DBP]: 124.9 ± 14.5/73.3 ± 9.9 mm Hg) of the 12-mo HealthTrack randomized controlled weight loss trial was conducted. Resting BP and 24-h urine sodium and potassium were measured...
July 27, 2016: Nutrition
Nancy R Cook, Lawrence J Appel, Paul K Whelton
BACKGROUND: The relationship between lower sodium intake and total mortality remains controversial. OBJECTIVES: This study examined the relationship between well-characterized measures of sodium intake estimated from urinary sodium excretion and long-term mortality. METHODS: Two trials, phase I (1987 to 1990), over 18 months, and phase II (1990 to 1995), over 36 months, were undertaken in TOHP (Trials of Hypertension Prevention), which implemented sodium reduction interventions...
October 11, 2016: Journal of the American College of Cardiology
Xiao-Wei Dai, Cheng Wang, Ying Xu, Ke Guan, Yi-Xiang Su, Yu-Ming Chen
Limited studies have examined the association between sodium (Na) and potassium (K) levels and the risk of atherosclerosis. This study examined whether higher Na and Na/K levels and low K levels were independent risk factors for atherosclerosis. This community-based cross-sectional study included 3290 subjects (1067 men and 2223 women) 40 to 75 years of age in Guangzhou, China, between 2011 and 2013. Urinary excretion of Na and K were measured from the first morning void, and creatinine-adjusted values were used...
October 1, 2016: Nutrients
Liuxia Yan, Xiaolei Guo, Huicheng Wang, Jiyu Zhang, Junli Tang, Zilong Lu, Xiaoning Cai, Longjian Liu, Edward J Gracely, Jixiang Ma
BACKGROUND AND OBJECTIVES: Albuminuria is a risk factor for cardiovascular and renal disease. However, little is known about the association of 24 h urinary sodium and potassium excretion with albuminuria in China. The aim of this study was to examine this association by analyzing the data from 1,975 Chinese adults living in north China. METHODS AND STUDY DESIGN: Excretion of urinary sodium, potassium and albumin was assessed in a single 24-h urine sample for each participant...
December 2016: Asia Pacific Journal of Clinical Nutrition
Lisa J Ware, Bianca Swanepoel, Aletta E Schutte
No abstract text is available yet for this article.
October 5, 2016: Public Health Nutrition
Tomomi Kogiso, Kuniko Yamamoto, Mutsuki Kobayashi, Yuichi Ikarashi, Kazuhisa Kodama, Makiko Taniai, Nobuyuki Torii, Etsuko Hashimoto, Katsutoshi Tokushige
AIMS: The vasopressin V2 receptor antagonist tolvaptan has been used for the treatment of cirrhotic patients with ascites; however, no predictor of efficacy and prognosis has been developed. Here, we evaluated candidate predictors of response to tolvaptan treatment. METHODS: This was a single-center retrospective study. Overall, 97 Japanese cirrhotic patients (60 males, median age 63 years), who were hospitalized for ascites treatment including oral tolvaptan coupled with conventional diuretics, were enrolled...
September 27, 2016: Hepatology Research: the Official Journal of the Japan Society of Hepatology
Wolley Mj, Wu A, Xu S, Gordon Rd, Fenton Ra, Stowasser M
BACKGROUND: Distal tubular sodium retention is a potent driver of hypertension, with the thiazide sensitive sodium-chloride cotransporter (NCC) a key player. The upstream modulators of NCC are unclear, but recent evidence has revealed the kinases 'with-no-lysine kinase 4' (WNK4) and 'STE20/SPS1-related, proline alanine-rich kinase' (SPAK) to be involved. The wider role of mineralocorticoids is poorly understood, but animal models implicate aldosterone as a potent regulator, possibly via effects on plasma potassium...
September 2016: Journal of Hypertension
Hongye Zhang, Qing Wang, Yu Guo, Dongfeng Li, Buqiang Zhang, Yuehong Dong, Xiuxian Huang, Yongjuan Liu, JInguo Zhao, Weiwei Li, Hans R Brunner, Lisheng Liu
OBJECTIVE: To observe the long-term (3 years) consumption of enriched potassium salt (KCL/NaCL = 1:1 by weight) on all causes mortality and target organ damage in Chinese living in nursing houses. DESIGN AND METHOD: The study was designed as a single blind prospective intervention. Participants were living in 22 nursing houses in northern China. The nursing houses were randomized into 2 groups: normal salt (control group) and enriched potassium salt (intervention group)...
September 2016: Journal of Hypertension
Lu Yin, Xinhua Zhang, Xingyu Wang, Yang Wang, Jian Bo, Wei Li
OBJECTIVE: To evaluate the association of systolic blood pressure (SBP) and diastolic blood pressure (DBP) with ratio for urinary sodium versus potassium in a large prospective urban and rural epidemiological study in China (PURE-China). DESIGN AND METHOD: As the important part of global multi-center PURE study, a prospective cohort study was conducted to recruit 46,285 participants in urban and rural area of 12 provinces in China between 2005 and 2009. A single fasting morning urine specimen was collected to test sodium and potassium excretion, and the Kawasaki formula was used to estimate 24-hour urinary sodium and potassium excretion...
September 2016: Journal of Hypertension
Chao Chu, Yumeng Cao, Jianjun Mu
BACKGROUND: Salt reduction are crucial in the management of hypertension. Over the past few decades, Series of national activities and studies focusing on salt reduction and salt intake education were promoted by the Chinese government. However, the current status of dietary sodium and potassium intake of Chinese population is unclear. OBJECTIVE: The aim of this study is to analyze the status of dietary salt and potassium intake in the Chinese population through summarizing the previous studies from 1998 to 2011 and then propose appropriate initiatives...
September 2016: Journal of Hypertension
Lyanne M Kieneker, Stephan J L Bakker, Rudolf A de Boer, Gerjan J Navis, Ron T Gansevoort, Michel M Joosten
It is unclear whether sodium and potassium intake is relevant to the development of chronic kidney disease (CKD) in the general population. Our aim was to examine the associations of urinary sodium (UNaV) and potassium excretion (UKV), as estimates of intake, with risk of developing CKD in a population-based cohort. We studied 5315 individuals free of CKD at baseline of the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study, a prospective, population-based cohort of Dutch men and women aged 28 to 75 years...
October 2016: Kidney International
D Lemogoum, Y Hako, C Bika Lele, C Okalla, J Dissongo, J M'buyamba-Kabangu, J Degaute, M Leeman, P van de Borne
OBJECTIVE: To assess the association between 24 hours urinary sodium and potassium excretion with blood pressure (BP) in rural and urban pygmies and Bantus of southern Cameroon. DESIGN AND METHOD: In this cross-sectional survey, we compared 100 traditional pygmies (TP) living in equatorial forest (Lolodorf) and their 100 neighbors traditional Bantus (TB) living in Bidjouka village, to 100 contemporary pygmies (CP) and 100 contemporary Bantus (CB) both living in urban environment in Kribi city...
September 2016: Journal of Hypertension
Martin J Wolley, Aihua Wu, Shengxin Xu, Richard D Gordon, Robert A Fenton, Michael Stowasser
Distal tubular sodium retention is a potent driver of hypertension, and the thiazide-sensitive sodium-chloride cotransporter (NCC) has a key role in this process. In humans, factors regulating NCC are unclear, but in animal models, aldosterone is a potent regulator, possibly via effects on plasma potassium. We studied the effects of the mineralocorticoid fludrocortisone on the abundance of NCC and its phosphorylated form (pNCC) as well as WNK lysine deficient protein kinase 4 (WNK4) and STE20/SPS1-related, proline alanine-rich kinase (SPAK) in human urinary exosomes...
July 5, 2016: Journal of the American Society of Nephrology: JASN
Muneyuki Kadota, Takayuki Ise, Shusuke Yagi, Takashi Iwase, Masashi Akaike, Rie Ueno, Yutaka Kawabata, Tomoya Hara, Kozue Ogasawara, Mika Bando, Sachiko Bando, Tomomi Matsuura, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masataka Sata
The renin-angiotensin-aldosterone system (RAAS) and arginine vasopressin (AVP) regulate body fluids. Although conventional diuretics have been used for treating heart failure, they activate RAAS and exacerbate renal function. Tolvaptan, a newly developed vasopressin-2 receptor antagonist, elicits aquaresis and improves volume overload in heart failure patients, however, the predictors of tolvaptan effectiveness and the influence on the RAAS and renal function according to tolvaptan therapy are not established...
July 27, 2016: International Heart Journal
Takanobu Nagata, Hiroshi Sobajima, Norimi Ohashi, Akihiro Hirakawa, Takayuki Katsuno, Yoshinari Yasuda, Seiichi Matsuo, Naotake Tsuboi, Shoichi Maruyama
BACKGROUND: Data regarding the association between 24h urinary sodium and potassium excretion with kidney outcomes in patients with diabetes mellitus is currently scarce. METHODS: We conducted a single-center, retrospective cohort study in which 1230 patients with diabetes who had undergone a 24h urinary sodium and potassium excretion test were analyzed. Patients with incomplete urine collection were excluded based on 24h urinary creatinine excretion. Outcomes were the composite of a 30% decline in eGFR or death...
2016: PloS One
Minami Sugimoto, Keiko Asakura, Shizuko Masayasu, Satoshi Sasaki
The effectiveness of better nutrition knowledge and dietary behavior on healthier dietary intake is still controversial. We hypothesized that nutritional knowledge and dietary behavior are associated with sodium and potassium intake in adult women. A cross-sectional study was conducted at welfare facilities located in 20 areas of Japan. Ninety-nine female dietitians and 117 nondietitians aged 20 to 69 years participated. Sodium and potassium intake were assessed with two 24-hour urine collections and 4-day semiweighed diet records...
May 2016: Nutrition Research
Carla Gonçalves, Sandra Abreu, Patrícia Padrão, Olívia Pinho, Pedro Graça, João Breda, Rute Santos, Pedro Moreira
BACKGROUND: Hypertension is the leading cause for heart disease and stroke, for mortality and morbidity worldwide, and a high sodium-to-potassium intake ratio is considered a stronger risk factor for hypertension than sodium alone. OBJECTIVE: This study aims to evaluate sodium and potassium urinary excretion, and assess the food sources of these nutrients in a sample of Portuguese adolescents. DESIGN: A cross-sectional study with a sample of 250 Portuguese adolescents...
2016: Food & Nutrition Research
A Barnado, A Oeser, Y Zhang, C R Okafor, J Titze, C M Stein, C P Chung
Sodium and potassium intake are modifiable determinants of hypertension in the general population but have not been studied in patients with systemic lupus erythematosus (SLE). We examined the relationship between urinary excretion of sodium and potassium, as an estimate of intake, and blood pressure in patients with SLE. We studied 178 SLE patients and 86 controls, matched for age, sex, and race. Urine sodium (Na(+)) and potassium (K(+)) were measured by flame photometry. Blood pressure was the average of two resting measurements...
April 6, 2016: Lupus
H T Ling, R Huang, X X Liang, Z X Li, J Wang, J B Tan, S X Wu, P Wang, Z H Chen, Q Huang, Y J Lyu, Q Jiang, X F Yang, Y N Wu
OBJECTIVE: To investigate the effect of long-term exposure to environmental cadmium on eight mineral element's metabolic balance of human body. METHODS: To choose a high cadmium area polluted by smelting and mining north of Guangdong province and a cadmium-free area with a similar economic level, and living and eating habit of residents as a contrast from April 2011 to August 2012. Stratified random sampling and clustered sampling method were adopted to choose the non-occupationally cadmium-exposed respondents who have lived in local area for more than 15 years, older than 40 years, having local rice and vegetable as the main dietary source, with simple and relatively stable diet, and without diabetes, kidney disease, thyroid disease, liver disease or other history of chronic disease...
April 2016: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
Xianlei Cai, Xueying Li, Wenjie Fan, Wanqi Yu, Shan Wang, Zhenhong Li, Ethel Marian Scott, Xiuyang Li
The objective of this study was to investigate the associations between potassium and obesity/metabolic syndrome. We identified eight relevant studies and applied meta-analysis, and nonlinear dose-response analysis to obtain the available evidence. The results of the pooled analysis and systematic review indicated that high potassium intake could not reduce the risk of obesity (pooled OR = 0.78; 95% CI: 0.61-1.01), while serum potassium and urinary sodium-to-potassium ratio was associated with obesity. Potassium intake was associated with metabolic syndrome (pooled OR = 0...
2016: Nutrients
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