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Urinary sodium potassium ratio

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https://www.readbyqxmd.com/read/28289182/continuum-of-renin-independent-aldosteronism-in-normotension
#1
Rene Baudrand, Francisco J Guarda, Carlos Fardella, Gregory Hundemer, Jenifer Brown, Gordon Williams, Anand Vaidya
Primary aldosteronism is a severe form of autonomous aldosteronism. Milder forms of autonomous and renin-independent aldosteronism may be common, even in normotension. We characterized aldosterone secretion in 210 normotensives who had suppressed plasma renin activity (<1.0 ng/mL per hour), completed an oral sodium suppression test, received an infusion of angiotensin II, and had measurements of blood pressure and renal plasma flow. Continuous associations between urinary aldosterone excretion rate, renin, and potassium handling were investigated...
March 13, 2017: Hypertension
https://www.readbyqxmd.com/read/28273873/interaction-between-single-nucleotide-polymorphism-and-urinary-sodium-potassium-and-sodium-potassium-ratio-on-the-risk-of-hypertension-in-korean-adults
#2
Yeong Mi Park, Chang Keun Kwock, Kyunga Kim, Jihye Kim, Yoon Jung Yang
Hypertension is a complex disease explained with diverse factors including environmental factors and genetic factors. The objectives of this study were to determine the interaction effects between gene variants and 24 h estimated urinary sodium and potassium excretion and sodium-potassium excretion ratios on the risk of hypertension. A total of 8839 participants were included in the genome-wide association study (GWAS) to find genetic factors associated with hypertension. Tanaka and Kawasaki formulas were applied to estimate 24 h urinary sodium and potassium excretion...
March 5, 2017: Nutrients
https://www.readbyqxmd.com/read/28213045/identification-of-the-causes-for-chronic-hypokalemia-importance-of-urinary-sodium-and-chloride-excretion
#3
Kun-Lin Wu, Chih-Jen Cheng, Chih-Chen Sung, Ming-Hua Tseng, Yu-Juei Hsu, Sung-Sen Yang, Tom Chau, Shih-Hua Lin
BACKGROUND: Uncovering the correct diagnosis of chronic hypokalemia with potassium (K(+)) wasting from the kidneys or gut can be fraught with challenges. We identified clinical and laboratory parameters helpful for differentiating the causes of chronic hypokalemia. METHODS: Normotensive patients referred to our tertiary academic medical center for the evaluation of chronic hypokalemia were prospectively enrolled over five years. Clinical features, laboratory examinations-including blood and spot urine electrolytes, acid-base status, biochemistries and hormones-as well as genetic analysis were determined...
February 14, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28127859/sodium-and-potassium-urinary-excretion-levels-of-preschool-children-individual-daily-and-seasonal-differences
#4
Kenichiro Yasutake, Mikako Nagafuchi, Ryoji Izu, Tomomi Kajiyama, Katsumi Imai, Yusuke Murata, Kenji Ohe, Munechika Enjoji, Takuya Tsuchihashi
In this study, the authors measured sodium and potassium concentrations in spot urine samples of preschool children on multiple days, and evaluated individual, daily, and seasonal effects. A total of 104 healthy preschool children aged 4 to 5 years were studied. Urine samples were collected from the first urine of the day after waking for three consecutive days (Monday-Wednesday) four times a year (spring, summer, autumn, winter). The authors estimated the daily urine volume as 500 mL and daily creatinine excretion as 300 mg, and used these to calculate daily sodium and potassium excretion levels...
January 27, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28123179/diurnal-variation-of-urinary-sodium-to-potassium-ratio-in-free-living-japanese-individuals
#5
Toshiyuki Iwahori, Hirotsugu Ueshima, Sayuki Torii, Yoshino Saito, Keiko Kondo, Sachiko Tanaka-Mizuno, Hisatomi Arima, Katsuyuki Miura
High sodium-to-potassium ratios are associated with elevated blood pressure levels and an increased risk of cardiovascular diseases. We aimed to determine whether urinary sodium-to-potassium ratios fluctuate diurnally during the day to understand measured values of casual urinary sodium-to-potassium ratios. A total of 13,277 casual urine specimens were collected under free-living conditions from 122 Japanese normotensive and hypertensive individuals. Participants collected all casual urine samples in aliquot tubes, reported urine volumes and the time at each voiding for 10-22 days...
January 26, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28106712/very-low-protein-diet-vlpd-reduces-metabolic-acidosis-in-subjects-with-chronic-kidney-disease-the-nutritional-light-signal-of-the-renal-acid-load
#6
Biagio Raffaele Di Iorio, Lucia Di Micco, Stefania Marzocco, Emanuele De Simone, Antonietta De Blasio, Maria Luisa Sirico, Luca Nardone, On Behalf Of Ubi Study Group
BACKGROUND: Metabolic acidosis is a common complication of chronic kidney disease; current guidelines recommend treatment with alkali if bicarbonate levels are lower than 22 mMol/L. In fact, recent studies have shown that an early administration of alkali reduces progression of CKD. The aim of the study is to evaluate the effect of fruit and vegetables to reduce the acid load in CKD. METHODS: We conducted a case-control study in 146 patients who received sodium bicarbonate...
January 17, 2017: Nutrients
https://www.readbyqxmd.com/read/28039381/estimating-24-h-urinary-sodium-potassium-ratio-from-casual-spot-urinary-sodium-potassium-ratio-the-intersalt-study
#7
Toshiyuki Iwahori, Katsuyuki Miura, Hirotsugu Ueshima, Queenie Chan, Alan R Dyer, Paul Elliott, Jeremiah Stamler
BACKGROUND: Association between casual and 24-h urinary sodium-to-potassium (Na/K) ratio is well recognized, although it has not been validated in diverse demographic groups. Our aim was to assess utility across and within populations of casual urine to estimate 24-h urinary Na/K ratio using data from the INTERSALT Study. METHODS: The INTERSALT Study collected cross-sectional standardized data on casual urinary sodium and potassium and also on timed 24-h urinary sodium and potassium for 10 065 individuals from 52 population samples in 32 countries (1985-87)...
December 30, 2016: International Journal of Epidemiology
https://www.readbyqxmd.com/read/27935977/the-effects-of-a-community-based-sodium-reduction-program-in-rural-china-a-cluster-randomized-trial
#8
Nicole Li, Lijing L Yan, Wenyi Niu, Chen Yao, Xiangxian Feng, Jianxin Zhang, Jingpu Shi, Yuhong Zhang, Ruijuan Zhang, Zhixin Hao, Hongling Chu, Jing Zhang, Xian Li, Jianhong Pan, Zhifang Li, Jixin Sun, Bo Zhou, Yi Zhao, Yan Yu, Michael Engelgau, Darwin Labarthe, Jixiang Ma, Stephen MacMahon, Paul Elliott, Yangfeng Wu, Bruce Neal
BACKGROUND: Average sodium intake and stroke mortality in northern China are both among the highest in the world. An effective, low-cost strategy to reduce sodium intake in this population is urgently needed. OBJECTIVE: We sought to determine the effects of a community-based sodium reduction program on salt consumption in rural northern China. DESIGN: This study was a cluster-randomized trial done over 18 months in 120 townships (one village from each township) from five provinces...
2016: PloS One
https://www.readbyqxmd.com/read/27896362/the-association-between-urinary-sodium-to-potassium-ratio-and-bone-density-in-middle-aged-chinese-adults
#9
W T Cao, J He, G D Chen, C Wang, R Qiu, Y M Chen
The joint effect of sodium and potassium on bone health remains uncertain. We examined the associations between urinary excretion of sodium, potassium, and their ratio and bone mineral density (BMD), and reported an inverse association between urinary sodium-to-potassium ratio and BMD in women, but not in men. INTRODUCTION: Several studies have suggested that a higher sodium or lower potassium intake is associated with poor bone health. However, few studies have examined their joint effects...
November 28, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27754020/chl-02-3-evidence-and-initiatives-in-the-dietary-salt-reduction-in-china
#10
Chao Chu, Yumeng Cao, Jianjun Mu
BACKGROUND: Salt reduction are crucial in the management of hypertension. Over the past few decades, Series of national activities and studies focusing on salt reduction and salt intake education were promoted by the Chinese government. However, the current status of dietary sodium and potassium intake of Chinese population is unclear. OBJECTIVE: The aim of this study is to analyze the status of dietary salt and potassium intake in the Chinese population through summarizing the previous studies from 1998 to 2011 and then propose appropriate initiatives...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27753931/os-05-06-in-primary-aldosteronism-mineralocorticoids-and-potassium-influence-abundance-of-the-thiazide-sensitive-sodium-chloride-cotransporter
#11
Wolley Mj, Wu A, Xu S, Gordon Rd, Fenton Ra, Stowasser M
BACKGROUND: Distal tubular sodium retention is a potent driver of hypertension, with the thiazide sensitive sodium-chloride cotransporter (NCC) a key player. The upstream modulators of NCC are unclear, but recent evidence has revealed the kinases 'with-no-lysine kinase 4' (WNK4) and 'STE20/SPS1-related, proline alanine-rich kinase' (SPAK) to be involved. The wider role of mineralocorticoids is poorly understood, but animal models implicate aldosterone as a potent regulator, possibly via effects on plasma potassium...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27753914/os-03-06-effect-of-long-term-enriched-potassium-salt-consumption-on-all-causes-mortality-in-chinese-living-in-nursing-houses-a-preliminary-analysis
#12
Hongye Zhang, Qing Wang, Yu Guo, Dongfeng Li, Buqiang Zhang, Yuehong Dong, Xiuxian Huang, Yongjuan Liu, JInguo Zhao, Weiwei Li, Hans R Brunner, Lisheng Liu
OBJECTIVE: To observe the long-term (3 years) consumption of enriched potassium salt (KCL/NaCL = 1:1 by weight) on all causes mortality and target organ damage in Chinese living in nursing houses. DESIGN AND METHOD: The study was designed as a single blind prospective intervention. Participants were living in 22 nursing houses in northern China. The nursing houses were randomized into 2 groups: normal salt (control group) and enriched potassium salt (intervention group)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27753910/os-03-02-stronger-associations-of-urinary-sodium-to-potassium-ratio-with-blood-pressure-results-from-a-prospective-cohort-study-in-china
#13
Lu Yin, Xinhua Zhang, Xingyu Wang, Yang Wang, Jian Bo, Wei Li
OBJECTIVE: To evaluate the association of systolic blood pressure (SBP) and diastolic blood pressure (DBP) with ratio for urinary sodium versus potassium in a large prospective urban and rural epidemiological study in China (PURE-China). DESIGN AND METHOD: As the important part of global multi-center PURE study, a prospective cohort study was conducted to recruit 46,285 participants in urban and rural area of 12 provinces in China between 2005 and 2009. A single fasting morning urine specimen was collected to test sodium and potassium excretion, and the Kawasaki formula was used to estimate 24-hour urinary sodium and potassium excretion...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27712964/relationship-between-sodium-and-potassium-intake-and-blood-pressure-in-a-sample-of-overweight-adults
#14
Rhoda N Ndanuko, Linda C Tapsell, Karen E Charlton, Elizabeth P Neale, Katrina M O'Donnell, Marijka J Batterham
OBJECTIVE: The aim of this study was to examine the relationship between sodium and potassium intakes and blood pressure (BP) in a clinical sample. METHODS: Secondary analysis of baseline data from 328 participants (mean age: 43.6 ± 8 y, mean body mass index [BMI]: 32.4 ± 4.2 kg/m(2), mean systolic BP [SBP]/diastolic BP [DBP]: 124.9 ± 14.5/73.3 ± 9.9 mm Hg) of the 12-mo HealthTrack randomized controlled weight loss trial was conducted. Resting BP and 24-h urine sodium and potassium were measured...
January 2017: Nutrition
https://www.readbyqxmd.com/read/27712772/sodium-intake-and-all-cause-mortality-over-20-years-in-the-trials-of-hypertension%C3%A2-prevention
#15
Nancy R Cook, Lawrence J Appel, Paul K Whelton
BACKGROUND: The relationship between lower sodium intake and total mortality remains controversial. OBJECTIVES: This study examined the relationship between well-characterized measures of sodium intake estimated from urinary sodium excretion and long-term mortality. METHODS: Two trials, phase I (1987 to 1990), over 18 months, and phase II (1990 to 1995), over 36 months, were undertaken in TOHP (Trials of Hypertension Prevention), which implemented sodium reduction interventions...
October 11, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27706075/urinary-sodium-and-potassium-excretion-and-carotid-atherosclerosis-in-chinese-men-and-women
#16
Xiao-Wei Dai, Cheng Wang, Ying Xu, Ke Guan, Yi-Xiang Su, Yu-Ming Chen
Limited studies have examined the association between sodium (Na) and potassium (K) levels and the risk of atherosclerosis. This study examined whether higher Na and Na/K levels and low K levels were independent risk factors for atherosclerosis. This community-based cross-sectional study included 3290 subjects (1067 men and 2223 women) 40 to 75 years of age in Guangzhou, China, between 2011 and 2013. Urinary excretion of Na and K were measured from the first morning void, and creatinine-adjusted values were used...
October 1, 2016: Nutrients
https://www.readbyqxmd.com/read/27702722/population-based-association-between-urinary-excretion-of-sodium-potassium-and-its-ratio-with-albuminuria-in-chinese
#17
Liuxia Yan, Xiaolei Guo, Huicheng Wang, Jiyu Zhang, Junli Tang, Zilong Lu, Xiaoning Cai, Longjian Liu, Edward J Gracely, Jixiang Ma
BACKGROUND AND OBJECTIVES: Albuminuria is a risk factor for cardiovascular and renal disease. However, little is known about the association of 24 h urinary sodium and potassium excretion with albuminuria in China. The aim of this study was to examine this association by analyzing the data from 1,975 Chinese adults living in north China. METHODS AND STUDY DESIGN: Excretion of urinary sodium, potassium and albumin was assessed in a single 24-h urine sample for each participant...
December 2016: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27702413/urinary-sodium-to-potassium-ratio-it-may-be-smart-but-is-it-easy
#18
Lisa J Ware, Bianca Swanepoel, Aletta E Schutte
No abstract text is available yet for this article.
October 5, 2016: Public Health Nutrition
https://www.readbyqxmd.com/read/27670393/the-response-to-tolvaptan-and-its-effect-on-prognosis-in-cirrhotic-patients-with-ascites
#19
Tomomi Kogiso, Kuniko Yamamoto, Mutsuki Kobayashi, Yuichi Ikarashi, Kazuhisa Kodama, Makiko Taniai, Nobuyuki Torii, Etsuko Hashimoto, Katsutoshi Tokushige
AIMS: The vasopressin V2 receptor antagonist tolvaptan has been used for the treatment of cirrhotic patients with ascites; however, no predictor of efficacy and prognosis has been developed. Here, we evaluated candidate predictors of response to tolvaptan treatment. METHODS: This was a single-center retrospective study. Overall, 97 Japanese cirrhotic patients (60 males, median age 63 years), who were hospitalized for ascites treatment including oral tolvaptan coupled with conventional diuretics, were enrolled...
September 27, 2016: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/27643324/os-05-06-in-primary-aldosteronism-mineralocorticoids-and-potassium-influence-abundance-of-the-thiazide-sensitive-sodium-chloride-cotransporter
#20
Wolley Mj, Wu A, Xu S, Gordon Rd, Fenton Ra, Stowasser M
BACKGROUND: Distal tubular sodium retention is a potent driver of hypertension, with the thiazide sensitive sodium-chloride cotransporter (NCC) a key player. The upstream modulators of NCC are unclear, but recent evidence has revealed the kinases 'with-no-lysine kinase 4' (WNK4) and 'STE20/SPS1-related, proline alanine-rich kinase' (SPAK) to be involved. The wider role of mineralocorticoids is poorly understood, but animal models implicate aldosterone as a potent regulator, possibly via effects on plasma potassium...
September 2016: Journal of Hypertension
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