keyword
https://read.qxmd.com/read/38320572/reduced-mir-99a-3p-levels-in-systemic-lupus-erythematosus-may-promote-b-cell-proliferation-via-ncapg-and-the-pi3k-akt-signaling-pathway
#1
JOURNAL ARTICLE
Qing-Huan Zhu, Ya-Li Zhou, Meng Yang, Bin-Bin Yang, Wen-Ting Cao, Li-Mei Yuan, Dan-Qi Deng
BACKGROUND: Systemic lupus erythematosus is an immunologically dysregulated disease characterized by the presence of multiple autoantibodies. In SLE, B lymphocytes contribute to the dysregulated production of autoantibodies and cytokines. Recently, we discovered that miR-99a-3p binds to both EIF4EBP1 and NCAPG mRNA and that lowering miR-99a-3p can promote B cell autophagy in SLE by increasing EIF4EBP1 expression. However, the functions of miR-99a-3p and NCAPG in SLE have not been extensively investigated...
April 2024: Lupus
https://read.qxmd.com/read/38285068/network-pharmacology-and-molecular-docking-to-elucidate-the-common-mechanism-of-hydroxychloroquine-treatment-in-lupus-nephritis-and-iga-nephropathy
#2
JOURNAL ARTICLE
Yixuan Chen, Meiqi Lu, Mengshu Lin, Qing Gao
OBJECTIVE: Hydroxychloroquine (HCQ), characterized by a broad effect on immune regulation, has been widely used in the treatment of autoimmune glomerulonephritis such as lupus nephritis (LN) and immunoglobulin A nephropathy (IgAN). The current research investigates whether HCQ plays a role in the treatment of LN and IgAN through common mechanisms since the pathogenesis of both LN and IgAN is closely related to immune complex deposition, complement activation, and ultimately inflammation...
January 29, 2024: Lupus
https://read.qxmd.com/read/38270299/cordyceps-cicadae-ameliorates-inflammatory-responses-oxidative-stress-and-fibrosis-by-targeting-the-pi3k-mtor-mediated-autophagy-pathway-in-the-renal-of-mrl-lpr-mice
#3
JOURNAL ARTICLE
Feng Yang, Yanyan Zhang, Lei Dong, Zhichao Song
BACKGROUND: The vast majority of systemic lupus erythematosus patients develop lupus nephritis (LN) with severe renal manifestations, such as inflammatory responses, oxidative stress, and fibrosis. The purpose of this research was to investigate Cordyceps cicadae as a potential therapeutic target for treating inflammatory responses, oxidative stress, and fibrosis in LN. METHODS: The effects of C. cicadae on lupus symptoms in mice with LN were determined...
January 2024: Immunity, Inflammation and Disease
https://read.qxmd.com/read/37828492/advances-in-the-study-of-macrophage-polarization-in-inflammatory-immune-skin-diseases
#4
REVIEW
Tingting Xia, Shengping Fu, Ruilin Yang, Kang Yang, Wei Lei, Ying Yang, Qian Zhang, Yujie Zhao, Jiang Yu, Limei Yu, Tao Zhang
When exposed to various microenvironmental stimuli, macrophages are highly plastic and primarily polarized into the pro-inflammatory M1-type and the anti-inflammatory M2-type, both of which perform almost entirely opposing functions. Due to this characteristic, macrophages perform different functions at different stages of immunity and inflammation. Inflammatory immune skin diseases usually show an imbalance in the M1/M2 macrophage ratio, and altering the macrophage polarization phenotype can either make the symptoms worse or better...
October 12, 2023: Journal of Inflammation
https://read.qxmd.com/read/37742016/two-cases-of-successful-sirolimus-treatment-for-patients-with-activated-phosphoinositide-3-kinase-%C3%AE-syndrome-1
#5
JOURNAL ARTICLE
Lu Jiang, Xiaohan Hu, Qiang Lin, Ruyue Chen, Yunyan Shen, Yun Zhu, Qinying Xu, Xiaozhong Li
BACKGROUND: Activated phosphoinositide3-kinase (PI3K) δ syndrome 1 (APDS1) is a novel inborn errors of immunity (IEIs) caused by heterozygous gain of function mutations in PI3Kδ catalytic p110δ (PIK3CD). APDS1 has a spectrum of clinical manifestations. Recurrent respiratory infections, lymphoproliferation, hepatosplenomegaly, hyper-IgM syndrome and autoimmunity are the common symptoms of this disease. CASE PRESENTATION: Patient 1 presented with recurrent respiratory infections, hepatosplenomegaly and hyper-IgM syndrome...
September 23, 2023: Allergy, Asthma, and Clinical Immunology
https://read.qxmd.com/read/37586763/abnormally-high-expression-of-d1-like-dopamine-receptors-on-lupus-cd4-t-cells-promotes-tfh-cell-differentiation
#6
JOURNAL ARTICLE
Fengxi Wu, Zhongyuan Xiang, Zhenghao He, Ping Yi, Ming Yang, Haijing Wu, Min Hu
OBJECTIVE: SLE is a chronic autoimmune disease that places a great burden on human society. T follicular helper (Tfh) cells play a critical role in the pathological process of SLE. Therefore, elucidating the mechanism of Tfh cell differentiation will contribute to SLE treatment. Dopamine receptors (DRDs) are members of the family of G protein-coupled receptors and are primarily divided into D1-like and D2-like receptors. Previous studies have found that DRDs can regulate differentiation of immune cells...
August 2023: Lupus Science & Medicine
https://read.qxmd.com/read/37585411/membrane-metalloendopeptidase-mme-is-positively-correlated-with-systemic-lupus-erythematosus-and-may-inhibit-the-occurrence-of-breast-cancer
#7
JOURNAL ARTICLE
Jiatong Ding, Chenxi Li, Kexin Shu, Wanying Chen, Chenxi Cai, Xin Zhang, Wenxiong Zhang
BACKGROUND: Patients with systemic lupus erythematosus (SLE) have a lower risk of breast cancer (BRCA) than the general population. In this study, we explored the underlying molecular mechanism that is dysregulated in both diseases. METHODS: Weighted gene coexpression network analysis (WGCNA) was executed with the SLE and BRCA datasets from the Gene Expression Omnibus (GEO) website and identified the potential role of membrane metalloendopeptidase (MME) in both diseases...
2023: PloS One
https://read.qxmd.com/read/37431601/role-of-artesunate-in-autoimmune-diseases-and-signaling-pathways
#8
REVIEW
Jingsai Gu, Yishuang Xu, Dihao Hua, Zhen Chen
Artesunate (ART) is a derivative of artemisinin. Compared with artemisinin, ART has excellent water solubility, high stability and oral bioavailability. In this review, the application of ART in classic autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus and ulcerative colitis is summarized. ART exhibited similar or even better efficacy than other highly effective immunosuppressive agents, such as methotrexate and cyclophosphamide. In addition, ART exerts its pharmacological effects mainly by inhibiting the production of inflammatory factors, reactive oxygen species, autoantibodies and the migration of cells to reduce damage to tissues or organs...
July 11, 2023: Immunotherapy
https://read.qxmd.com/read/37256149/b-cell-activation-via-immunometabolism-in-systemic-lupus-erythematosus
#9
REVIEW
Shigeru Iwata, Maiko Hajime Sumikawa, Yoshiya Tanaka
Systemic lupus erythematosus (SLE) is an inflammatory autoimmune disease involving multiple organs in which B cells perform important functions such as antibody and cytokine production and antigen presentation. B cells are activated and differentiated by the primary B cell receptor, co-stimulatory molecule signals-such as CD40/CD40L-, the Toll-like receptors 7,9, and various cytokine signals. The importance of immunometabolism in the activation, differentiation, and exerting functions of B cells and other immune cells has been widely reported in recent years...
2023: Frontiers in Immunology
https://read.qxmd.com/read/36961448/mtor-activation-underlies-enhanced-b-cell-proliferation-and-autoimmunity-in-prkcdg510s-g510s-mice
#10
JOURNAL ARTICLE
Marion Moreews, Anne-Laure Mathieu, Kevin Pouxvielh, Quentin Reuschlé, Annabelle Drouillard, Pénélope Dessay, Marie Meignien, Jiang Zhang, Lucie Fallone, Noëmi Rousseaux, Michelle Ainouze, Amaury Rey, Ommar Omarjee, Elodie Decembre, Vanina Lenief, Sophia Djebali, Olivier Thaunat, Marlène Dreux, Laurent Genestier, Thierry Defrance, Pauline Soulas-Sprauel, Antoine Marçais, Thierry Walzer, Alexandre Belot
Autosomal recessive PRKCD deficiency has previously been associated with the development of systemic lupus erythematosus in human patients, but the mechanisms underlying autoimmunity remain poorly understood. We introduced the Prkcd G510S mutation that we previously associated to a Mendelian cause of systemic lupus erythematosus in the mouse genome, using CRISPR-Cas9 gene editing. PrkcdG510S/G510S mice recapitulated the human phenotype and had reduced lifespan. We demonstrate that this phenotype is linked to a B cell-autonomous role of Prkcd...
March 24, 2023: Journal of Immunology
https://read.qxmd.com/read/36948005/increased-levels-of-il-17-and-autoantibodies-following-bisphenol-a-exposure-were-associated-with-activation-of-pi3k-akt-mtor-pathway-and-abnormal-autophagy-in-mrl-lpr-mice
#11
JOURNAL ARTICLE
Youdan Dong, Liang Gao, Qi Sun, Lihong Jia, Dongmei Liu
Bisphenol A (BPA) is a common environmental endocrine disruptor which mimic the effect of estrogen. The immunotoxicity of BPA has attracted widespread attention in recent years. However, the effects and mechanism of BPA on autoimmune disease were rarely reported. Systemic lupus erythematosus (SLE) is a typical autoimmune disease, and its etiology and mechanism are complex and unclear. Currently, inflammation and the production of autoantibodies are considered to be important pathological mechanisms of SLE, and estrogen contributes to the occurrence and development of SLE...
March 20, 2023: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/36870831/proteomic-characterization-and-comparison-of-milk-fat-globule-membrane-proteins-of-saanen-goat-milk-from-3-habitats-in-china-using-swath-ms-technique
#12
JOURNAL ARTICLE
Cuina Wang, Ru Zhao, Zixuan Zhao, Ning Liu, Jianjun Cheng, Mingruo Guo
Saanen goats are among the major dairy goats in China. In present study, variation of milk fat globule membrane proteins profile of Saanen goat milk caused by geographic location was investigated using sequential window acquisition of all theoretical fragment ions data-independent acquisition mass spectrometry based proteomic approach. A total of 1,001 proteins were quantified in goat milk collected from 3 habitats of China [Guangdong (GD); Inner Mongolia (IM); Shannxi (SX)]. Most of the proteins were found to act cellular process of biological process, cell of cellular component, binding of molecular function after Gene Ontology annotation and metabolic of pathway indicated by Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis...
March 2, 2023: Journal of Dairy Science
https://read.qxmd.com/read/36652779/retraction-notice-to-bach2-regulates-aberrant-activation-of-b-cell-in-systemic-lupus-erythematosus-and-can-be-negatively-regulated-by-bcr-abl-pi3k-exp-cell-res-365-1-1-april-2018-pages-138-144
#13
Zhengwei Zhu, Chao Yang, Leilei Wen, Lu Liu, Xianbo Zuo, Fusheng Zhou, Jinping Gao, Xiaodong Zheng, Yinjuan Shi, Caihong Zhu, Bo Liang, Xianyong Yin, Wenjun Wang, Hui Cheng, Songke Shen, Xianfa Tang, Huayang Tang, Liangdan Sun, Anping Zhang, Sen Yang, Yong Cui, Xuejun Zhang, Yujun Sheng
No abstract text is available yet for this article.
February 15, 2023: Experimental Cell Research
https://read.qxmd.com/read/36482627/molecular-mechanism-of-qh-bj-drug-pair-in-the-treatment-of-systemic-lupus-erythematosus-based-on-network-pharmacology-and-molecular-docking
#14
JOURNAL ARTICLE
Ziyu Song, Lina Ji, Shan Wu, Yongsheng Fan, Qin Zhang, Kepeng Yang, Sijia Fang
To analyze the molecular mechanism of Qinghao-Biejia (QH-BJ) drug pair in the treatment of systemic lupus erythematosus (SLE) based on the method of network pharmacology and molecular docking technology. The components and related targets of QH-BJ drug pair, as well as SLE-related targets, were obtained. Intersection targets of QH-BJ drug pair and SLE were screened to construct the protein-protein interaction network, conduct gene ontology analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis, and establish the component-target-pathway network...
December 2, 2022: Medicine (Baltimore)
https://read.qxmd.com/read/36382136/regenerative-medicine-strategies-for-hair-growth-and-regeneration-a-narrative-review-of-literature
#15
REVIEW
Yusuke Shimizu, Edward Hosea Ntege, Hiroshi Sunami, Yoshikazu Inoue
Hair loss, or alopecia, is associated with several psychosocial and medical comorbidities, and it remains an economic burden to individuals and the society. Alopecia is attributable to varied mechanisms and features a multifactorial predisposition, and the available conventional medical interventions have several limitations. Thus, several therapeutic strategies for alopecia in regenerative medicine are currently being explored, with increasing evidence suggesting that mesenchymal stem cell (MSC) implantation, MSC-derived secretome treatment, and blood-derived platelet-rich plasma therapies are potential treatment options...
December 2022: Regenerative Therapy
https://read.qxmd.com/read/36378860/drug-repositioning-identifies-six-drug-candidates-for-systemic-autoimmune-diseases-by-integrative-analyses-of-transcriptomes-from-scleroderma-systemic-lupus-erythematosus-and-sjogren-s-syndrome
#16
JOURNAL ARTICLE
Elif Kubat Oktem, Metin Yazar
The mechanisms of systemic autoimmune diseases (ADs) are still not clearly understood. Understanding the etiology of systemic ADs and identifying new therapeutic targets require a systems science approach. Using publicly available transcriptome data and bioinformatic analysis, we investigated the differential gene expression profiles of patients with scleroderma, systemic lupus erythematosus, and Sjogren's syndrome. Of these common differentially expressed gene signatures, 208 were regulated in the same direction (either upregulated or downregulated in all datasets) and used for drug repositioning...
November 15, 2022: Omics: a Journal of Integrative Biology
https://read.qxmd.com/read/36353692/investigating-sex-differences-in-t-regulatory-cells-from-cisgender-and-transgender-healthy-individuals-and-patients-with-autoimmune-inflammatory-disease-a-cross-sectional-study
#17
JOURNAL ARTICLE
George A Robinson, Junjie Peng, Hannah Peckham, Gary Butler, Ines Pineda-Torra, Coziana Ciurtin, Elizabeth C Jury
BACKGROUND: Sexual dimorphisms, which vary depending on age group and pubertal status, have been described across both the innate and adaptive immune system. We explored the influence of sex hormones on immune phenotype in the context of adolescent health and autoimmunity. METHODS: In this cross-sectional study, healthy, post-pubertal cisgender individuals (aged 16-25 years); healthy, pre-pubertal cisgender individuals (aged 6-11 years); transgender individuals (aged 18-19 years) undergoing gender-affirming treatment (testosterone in individuals assigned female sex at birth and oestradiol in individuals assigned male sex at birth); and post-pubertal cisgender individuals (aged 14-25 years) with juvenile-onset systemic lupus erythematosus (SLE) age-matched to cisgender individuals without juvenile-onset SLE were eligible for inclusion...
October 2022: Lancet Rheumatology
https://read.qxmd.com/read/36304300/investigating-the-molecular-mechanism-of-iguratimod-act-on-sle-using-network-pharmacology-and-molecular-docking-analysis
#18
JOURNAL ARTICLE
Huiqiong Zeng, Shuai Chen, Xiaoping Lu, Zhenbo Yan
Objective: Iguratimod ( IGU ) is a novel small disease-modifying compound widely used in Asia for the treatment of rheumatic diseases. IGU is a methane sulfonanilide. We applied network pharmacology to investigate the pharmacological mechanisms of IGU act on SLE. Methods: We used PharmMapper, UniProt, and OMIM databases to screen the potential targets of IGU , and the SLE-related disease targets were predicted. Hub target genes among the intersections of the potential targets ( IGU ) and related genes (SLE) were validated using the PPI network generated by the String database...
2022: Front Bioinform
https://read.qxmd.com/read/36265758/mtor-signaling-a-pivotal-player-in-treg-cell-dysfunction-in-systemic-lupus-erythematosus
#19
REVIEW
Xingyun Zhao, Shifen Wang, Shengjun Wang, Jue Xie, Dawei Cui
Systemic lupus erythematosus (SLE) is a typical autoimmune disease characterized by multiorgan involvement and marked variability in clinical presentation. SLE pathogenesis includes regulatory T cell dysfunction and antinuclear antibody production. Mammalian target of rapamycin (mTOR), a serine/threonine kinase in the phosphoinositide 3-kinase (PI3K)-related kinase family, is a therapeutic target for autoimmune diseases such as SLE. Rapamycin, an inhibitor of the mTOR signaling pathway, is a macrolide antibiotic with potent immunosuppressive, antiproliferative and antifibrotic effects...
October 17, 2022: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/36243851/the-role-of-pi3k-isoforms-in-autoimmune-disease
#20
JOURNAL ARTICLE
Stephen G Ward
Aberrant overactivation of the immune system can give rise to chronic and persistent self-attack, culminating in autoimmune disease. This is currently managed therapeutically using potent immunosuppressive and anti-inflammatory drugs. Class I phosphoinositide-3-kinases (PI3Ks) have been identified as ideal therapeutic targets for autoimmune diseases given their wide-ranging roles in immunological processes. Although progress has been hampered by issues such as poor drug tolerance and drug resistance, several PI3K inhibitors have now received regulatory approval with many others in development, including several intended to suppress the immune response in autoimmune and inflammatory diseases...
2022: Current Topics in Microbiology and Immunology
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