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Bone graft material in implant dentistry

Wei Qiao, Quan Liu, Zhipeng Li, Hanqing Zhang, Zhuofan Chen
As the main inorganic component of xenogenic bone graft material, bone-derived biological apatite (BAp) has been widely used in implant dentistry, oral and maxillofacial surgery and orthopedics. However, BAp produced via calcination of animal bones still suffers from some drawbacks, such as insufficient mechanical strength and inadequate degradation rate, which impede its application. Fluoride is known to play important roles in both physiological and pathological processes of human hard tissues for its double effects on bones and teeth...
2017: Science and Technology of Advanced Materials
Paul Fletcher, Daniel Deluiz, Eduardo Mb Tinoco, John L Ricci, Dennis P Tarnow, Justine Monnerat Tinoco
The treatment of peri-implant disease is one of the most controversial topics in implant dentistry. The multifactorial etiology and the myriad proposed techniques for managing the problem make successful decontamination of an implant surface affected by peri-implantitis one of the more unpredictable challenges dental practitioners have to face. This article presents the first known published case report demonstrating human histologic evidence of reosseointegration using a plastic curette for mechanical debridement and dilute sodium hypochlorite, hydrogen peroxide, and sterile saline for chemical detoxification...
February 14, 2017: International Journal of Periodontics & Restorative Dentistry
Rokhsareh Sadeghi, Mohammad Najafi, Hassan Semyari, Fatemeh Mashhadiabbas
PURPOSE: Bone regeneration is an important concern in periodontal treatment and implant dentistry. Different biomaterials and surgical techniques have been used for this purpose. The aim of the present study was to compare the effect of nanocrystalline hydroxyapatite and human freeze-dried bone graft (FDBG) in regeneration of rabbit calvarium bony defects by histologic and histomorphometric evaluation. METHODS: In this experimental study, three similar defects, measuring 8 mm in diameter, were created in the calvaria of 16 white New Zealand rabbits...
January 27, 2017: Journal of Orofacial Orthopedics, Fortschritte der Kieferorthopädie
Angel Manchon, Juan Carlos Prados-Frutos, Carmen Rueda Rodriguez, Carmen Salinas Goodier, Mohammad Hadman Alkhraisat, Rosa Rojo, Arantza Rodriguez Gonzalez, Ana Berlanga, Enrique Lopez Cabarcos
Calcium phosphate materials (CPM) are widely used in dentistry and maxillofacial surgery. The presence of microbial biofilms and external infections are responsible for the failure of many procedures of dental implants and bone grafts. In an attempt to reduce the percentage of these infectious processes antibiotics have been associated with CPM improving certain conditions. For instance antibiotics administered orally or intravenously have less effect and the blood flow in relation to this is poor near implants and grafts...
November 14, 2016: Current Pharmaceutical Biotechnology
Antonio Cortese, Giuseppe Pantaleo, Antonio Borri, Mario Caggiano, Massimo Amato
INTRODUCTION: Some studies have demonstrated that platelet rich fibrin (PRF) is a healing biomaterial with a great potential for bone and soft tissue regeneration, without any inflammatory reactions and may be used alone or in combination with bone grafts, promoting hemostasis, bone growth, and maturation. PRF appears as a natural and satisfactory aid in bone regenerative surgery in elderly patients with favorable results and low risks. AIM: This study wants to demonstrate how PRF in association with a new split crest augmentation technique can be a great aid in implant rehabilitation, especially in the elderly patients, when bone regeneration is required...
September 22, 2016: International Journal of Surgery Case Reports
Maíra Cavallet de Abreu, Deise Ponzoni, Renan Langie, Felipe Ernesto Artuzi, Edela Puricelli
The understanding of bone repair phenomena is a fundamental part of dentistry and maxillofacial surgery. Objective The present study aimed to evaluate the influence of buried magnetic field stimulation on bone repair in rat calvaria after reconstruction with autogenous bone grafts, synthetic powdered hydroxyapatite, or allogeneic cartilage grafts, with or without exposure to magnetic stimulation. Material and Methods Ninety male Wistar rats were divided into 18 groups of five animals each. Critical bone defects were created in the rats' calvaria and immediately reconstructed with autogenous bone, powdered synthetic hydroxyapatite or allogeneic cartilage...
April 2016: Journal of Applied Oral Science: Revista FOB
M-A Saghiri, A Asatourian, F Garcia-Godoy, N Sheibani
BACKGROUND: In implant dentistry, bone substitute materials and barrier membranes are used in different treatments including guided bone regeneration (GBR), socket preservation, alveolar ridge augmentation, maxillary sinus elevation, and filling bony defects around the inserted dental implant. One of the most important factors in prognosis of treatments using these materials is the growth of new blood vessels in applied areas. Present review was performed to evaluate the effect of the bone-grafting and barrier membrane materials on angiogenesis events...
July 1, 2016: Medicina Oral, Patología Oral y Cirugía Bucal
Richard J Miron, Qiao Zhang, Anton Sculean, Daniel Buser, Benjamin E Pippenger, Michel Dard, Yoshinori Shirakata, Fatiha Chandad, Yufeng Zhang
OBJECTIVES: Guided bone regeneration (GBR) aims to predictably restore missing bone that has been lost due to trauma, periodontal disease or a variety of systemic conditions. Critical to this procedure is the ability of a bone grafting material to predictably serve as a 3-dimensional scaffold capable of inducing cell and bone tissue in-growth at the material surface. Although all bone grafts are osteoconductive to bone-forming osteoblasts, only a small number of commercially available bone grafts with FDA approval are osteoinductive including demineralized freeze-dried bone allographs (DFDBA) and scaffolds containing bone morphogenetic proteins (BMPs)...
November 2016: Clinical Oral Investigations
Andrea Corrado Profeta, Gian Marco Prucher
Bioactive-glass (B-G) is a material known for its favorable biological response when in contact with surrounding fibro-osseous tissues, due not only to an osteoconductive property, but also to an osteostimulatory capacity, and superior biocompatibility for use in human body. The objectives of this paper are to review recent studies on B-G in periodontal and implant therapy, describing its basic properties and mechanism of activity as well as discoursing about state of art and future perspective of utilization...
2015: Dental Materials Journal
Sergio Rubinstein, Barry P Levin, Toshiyuki Fujiki
Whether it's a single tooth or multiple teeth, tooth loss has esthetic, functional, and health implications. Replacing multiple teeth can be especially complicated due to the loss of surrounding structures, often making it necessary to use additional procedures--eg, bone grafting--to solve the problems that arise. Fortunately, modern techniques and materials in dentistry enable clinicians to replace and mimic lost teeth in a realistic, healthy, and functional way like no other field in medicine. This report discusses two cases that involve multiple subspecialties working synergistically to accomplish ideal tooth replacement and emphasizes the importance of proper diagnosis, treatment planning, and execution of surgical and restorative therapy to achieve optimal results...
July 2015: Compendium of Continuing Education in Dentistry
Dustin Bowler, Harry Dym
Alveolar bone that is insufficient to support implant placement due to lack of height or width may be augmented with grafting materials including bone morphogenic protein to create sites that are adequate for implant placement and long-term stability of implant-supported prosthesis. Bone morphogenic protein can be used alone or in concert with other bone graft materials as an alternative to invasive allograft bone harvesting procedures.
April 2015: Dental Clinics of North America
O E Ogle, N Byles
A review was done of nanotechnology as it applies to dentistry today. Information was gathered from literature search, research data and material inserts in products.Nanotechnology deals with the physical, chemical and biological properties of structures and their components at nanoscale dimensions. One of the biggest contributionS to restorative and aesthetic dentistry has been nanocomposites. These composites are characterized by filler-particle sizes ≤ 100 nm and offer aesthetic and strength advantages over the current microfilled and hybrid resin-based composites...
August 2014: West Indian Medical Journal
Girish Nazirkar, Shailendra Singh, Vinaykumar Dole, Akhilesh Nikam
Since the beginning of the 20th century, the concept of osteoconduction in bony changes in the oral cavity showed a wide range of biomaterials and their osteoinductive potential that emerged gradually and has to a large extent improved the quality of the bone prior to the placement of an implant. Alveolar bone loss is a major concern after tooth extraction in patients and therefore atraumatic extraction procedures should be followed to avoid further bone loss. To overcome the alveolar bone loss and to augment support for placing dental implants, many bone regenerative substitutes are available such as allografts, autografts, xenografts, synthetic biomaterials and osteoactive agents...
June 2014: Journal of International Oral Health: JIOH
Shaeesta Khaleelahmed Bhavikatti, Smiti Bhardwaj, M L V Prabhuji
With the increasing demand for advances in diagnosis and treatment modalities, nanotechnology is being considered as a groundbreaking and viable research subject. This technology, which deals with matter in nanodimensions, has widened our views of poorly understood health issues and provided novel means of diagnosis and treatment. Researchers in the field of dentistry have explored the potential of nanoparticles in existing therapeutic modalities with moderate success. The key implementations in the field of dentistry include local drug delivery agents, restorative materials, bone graft materials, and implant surface modifications...
July 2014: General Dentistry
Anton Friedmann, Asisa Friedmann, Leticia Grize, Marcel Obrecht, Michel Dard
Implant dentistry demonstrated its reliability in treating successfully an increased amount of patients with dental implants exhibiting hydrophilic (modSLA) or non-hydrophilic (SLA) surfaces. Objectives of this minipig study consisted in assessing bone regeneration at both types of dental implants in a new experimental model (lateral bone defects) by implementing a convergent analysis approach combining histology and contact radiography. In six adult female minipigs standardized acute alveolar defects were created, then receiving two implants in the mandibles bilaterally (modSLA and SLA, one of each combined with Guided Bone Regeneration)...
May 2014: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
Saqib Ali, Imran Farooq, Kefi Iqbal
Bioactive glass is a novel material that dissolves and forms a bond with bone when exposed to body fluids. Bioactive glasses are silicate-based, with calcium and phosphate in identical proportions to those of natural bone; therefore, they have high biocompatibility. Bioactive glasses have wide-ranging clinical applications, including the use as bone grafts, scaffolds, and coating materials for dental implants. This review will discuss the effects of ions on the various compositions of bioactive glasses, as well as the clinical applications of bioactive glasses in medicine and dentistry...
January 2014: Saudi Dental Journal
Sidi A Bencherif, Thomas M Braschler, Philippe Renaud
A paradigm shift is taking place in medicine and dentistry from using synthetic implants and tissue grafts to a tissue engineering approach that uses degradable porous three-dimensional (3D) material hydrogels integrated with cells and bioactive factors to regenerate tissues such as dental bone and other oral tissues. Hydrogels have been established as a biomaterial of choice for many years, as they offer diverse properties that make them ideal in regenerative medicine, including dental applications. Being highly biocompatible and similar to native extracellular matrix, hydrogels have emerged as ideal candidates in the design of 3D scaffolds for tissue regeneration and drug delivery applications...
December 2013: Journal of Periodontal & Implant Science
Tie Liu, Gang Wu, Daniel Wismeijer, Zhiyuan Gu, Yuelian Liu
As an alternative to an autologous bone graft, deproteinized bovine bone (DBB) is widely used in the clinical dentistry. Although DBB provides an osteoconductive scaffold, it is not capable of enhancing bone regeneration because it is not osteoinductive. In order to render DBB osteoinductive, bone morphogenetic protein 2 (BMP-2) has previously been incorporated into a three dimensional reservoir (a biomimetic calcium phosphate coating) on DBB, which effectively promoted the osteogenic response by the slow delivery of BMP-2...
September 2013: Bone
Andreia Figueiredo, Patrícia Coimbra, António Cabrita, Fernando Guerra, Margarida Figueiredo
Two commercial bone grafts used in dentistry (Osteobiol Gen-Os®, a xenograft of porcine origin, and Bonelike®, a hydroxyapatite based synthetic material), in the form of granules, were characterized and evaluated in vivo regarding the intensity of the tissue inflammatory response. These biomaterials were characterized in terms of morphology, particle size distribution, porosity and pore size, specific surface area and density. The chemical composition and structure of the materials were accessed by Fourier-Transform Infrared Spectroscopy (FTIR) and X-ray Diffraction (XRD)...
August 1, 2013: Materials Science & Engineering. C, Materials for Biological Applications
Barbara Barboni, Carlo Mangano, Luca Valbonetti, Giuseppe Marruchella, Paolo Berardinelli, Alessandra Martelli, Aurelio Muttini, Annunziata Mauro, Rossella Bedini, Maura Turriani, Raffaella Pecci, Delia Nardinocchi, Vincenzo Luca Zizzari, Stefano Tetè, Adriano Piattelli, Mauro Mattioli
BACKGROUND: Evidence has been provided that a cell-based therapy combined with the use of bioactive materials may significantly improve bone regeneration prior to dental implant, although the identification of an ideal source of progenitor/stem cells remains to be determined. AIM: In the present research, the bone regenerative property of an emerging source of progenitor cells, the amniotic epithelial cells (AEC), loaded on a calcium-phosphate synthetic bone substitute, made by direct rapid prototyping (rPT) technique, was evaluated in an animal study...
2013: PloS One
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