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https://www.readbyqxmd.com/read/28639351/titanium-released-from-dental-implant-enhances-pre-osteoblast-adhesion-by-ros-modulating-crucial-intracellular-pathways
#1
M C Rossi, Fjb Bezerra, R A Silva, B P Crulhas, Cjc Fernandes, A S Nascimento, V A Pedrosa, P Padilha, W F Zambuzzi
It is important to understand the cellular and molecular events that occur at the cell-material interface of implants used for bone repair. The mechanisms involved in the initial stages of osteoblast interactions with the surface of the implant material must be decisive for cell fating surrounding them. In order to address this issue, we decided to investigate if conditioned medium for dental implants was able to modulate murine pre-osteoblast metabolism. First, we determined the concentration of titanium (Ti)-containing conditioned medium and found that it was 2-fold increased (p<0...
June 22, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28637981/effects-of-vascular-endothelial-growth-factor-on-osteoblasts-around-dental-implants-in-vitro-and-in-vivo
#2
Mengkai Guang, Bo Huang, Yang Yao, Liang Zhang, Bo Yang, Ping Gong
Vasculogenesis is a pivotal procedure during dental implant osseointegration and bone repair process. Vascular endothelial growth factor (VEGF), regarded as one of the most important vasculogenesis factor, also plays a central role in bone repair, but its role around dental implants is still unknown. In the present study, rat primary osteoblasts seeded on titanium discs were tested using proliferation, enzyme-linked immunosorbent assay, Real-time PCR, and alkaline phosphatase (ALP) expression. Chicken embryo chorioallantoic membrane (CAM) was used to test the vasculogenesis property...
2017: Journal of Oral Science
https://www.readbyqxmd.com/read/28632254/osteogenic-potential-of-gingival-mesenchymal-stem-cells-over-titanium-machined-surfaces
#3
Julio A Carrion, Junaid Rajani, Mohamed Al Bahrawy, Xiaojun Chan, Tae Jin Kim, Srinivas Myneni, Vincent J Iacono
PURPOSE: To evaluate the biochemical composition of bone nodules deposited by gingival mesenchymal stem cells (GMSCs) over titanium machined surfaces in vitro. MATERIALS AND METHODS: GMSCs were isolated from healthy gingival tissues of patients undergoing crown-lengthening surgical procedures. GMSCs were characterized following the International Society for Cellular Therapy guidelines. After incubation of the GMSCs with titanium discs, osteogenic differentiation was induced for 28 days...
June 20, 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28631408/resonance-frequency-analysis-of-dental-implants-placed-at-the-posterior-maxilla-varying-the-surface-treatment-only-a-randomized-clinical-trial
#4
Marcelo M Novellino, Newton Sesma, Piero R Zanardi, Dalva C Laganá
BACKGROUND: Chemical modifications of the dental implant surface that improve the wettability result in a faster and better osseointegration. PURPOSE: The aim of this randomized clinical trial was to evaluate the implant stability quotient (ISQ) of implants with similar designs, treated with 2 surfaces, sandblasted acid-etched (SAE) and hydrophilic SAE, within the initial 16 weeks of healing. MATERIAL AND METHODS: A total of 64 implants (32 SAE-control group and 32 modified SAE-test group) with the same design, length, and diameter (conical and compressive, 4...
June 20, 2017: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/28629062/construction-of-poly-lactic-co-glycolic-acid-zno-nanorods-ag-nanoparticles-hybrid-coating-on-ti-implants-for-enhanced-antibacterial-activity-and-biocompatibility
#5
Yiming Xiang, Jun Li, Xiangmei Liu, Zhenduo Cui, Xianjin Yang, K W K Yeung, Haobo Pan, Shuilin Wu
Poly(lactic-co-glycolic acid)/Ag/ZnO nanorods coating were successfully prepared on the surface of Ti metallic implants using a hydrothermal method and subsequent spin-coating of mixtures of poly(lactic-co-glycolic acid) and silver nanoparticles. The poly(lactic-co-glycolic acid)/Ag/ZnO nanorods coating exhibited excellent antibacterial efficacy of over 96% against both Staphylococcus aureus and Escherichia coli when the initial content of Ag nanoparticles was over 3wt%. In addition, the release of both silver and zinc could last for over a hundred days due to the enwrapping of poly(lactic-co-glycolic acid)...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28628354/soft-tissue-enhancement-and-implant-placement-following-partial-mandibulectomy-due-to-squamous-cell-carcinoma
#6
Fabio Bernardello, Giampietro Bertasi, Ralph Mackey Powers, Sergio Spinato, Andrea Viaggi, Jimmie Bullock, Pietro Felice
Many dental procedures allow for implant placement in partially or totally edentulous patients. Despite the availability of various implant and abutment types on the market, it often becomes quite challenging to achieve the biological and esthetic goals in a patient who has ridge deficiencies. Where problems will arise is from the lack of adequate bone quality and quantity.1,2 Soft tissue form and maintenance is also a consideration to evaluate.3 Primary reconstructive techniques following segmental mandibulectomy is evolving and improves quality of life...
June 19, 2017: Journal of Oral Implantology
https://www.readbyqxmd.com/read/28626970/surgical-treatment-of-peri-implantitis-intrabony-lesions-by-means-of-deproteinized-bovine-bone-mineral-with-10-collagen-7-year-results
#7
Mario Roccuzzo, Dario Pittoni, Andrea Roccuzzo, Lorena Charrier, Paola Dalmasso
OBJECTIVES: The aim of this study was to evaluate the long-term results of the surgical treatment of single peri-implantitis intrabony defects, by means of deproteinized bovine bone mineral with 10% collagen (DBBMC). MATERIAL AND METHODS: The original population consisted of 26 patients with one crater-like defect, around either sandblasted and acid-etched (SLA) or titanium plasma-sprayed (TPS) dental implants, with a probing depth (PD) ≥6 mm and no implant mobility (Roccuzzo et al...
June 18, 2017: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/28621746/biocompatibility-analyses-of-al%C3%A2-o%C3%A2-treated-titanium-plates-tested-with-osteocyte-and-fibroblast-cell-lines
#8
Alberto Smargiassi, Jessika Bertacchini, Marta Checchi, Francesco Cavani, Marzia Ferretti, Carla Palumbo
Osseointegration of a titanium implant is still an issue in dental/orthopedic implants durable over time. The good integration of these implants is mainly due to their surface and topography. We obtained an innovative titanium surface by shooting different-in-size particles of Al₂O₃ against the titanium scaffolds which seems to be ideal for bone integration. To corroborate that, we used two different cell lines: MLO-Y4 (murine osteocytes) and 293 (human fibroblasts) and tested the titanium scaffolds untreated and treated (i...
June 16, 2017: Biomedicines
https://www.readbyqxmd.com/read/28612506/synergistic-interactions-between-corrosion-and-wear-at-titanium-based-dental-implant-connections-a-scoping-review
#9
REVIEW
K Apaza-Bedoya, M Tarce, C A M Benfatti, B Henriques, M T Mathew, W Teughels, J C M Souza
Two-piece implant systems are mainly used in oral implantology involving an osseointegrated implant connected to an abutment, which supports prosthetic structures. It is well documented that the presence of microgaps, biofilms and oral fluids at the implant-abutment connection can cause mechanical and biological complications. The aim of this review paper was to report the degradation at the implant-abutment connection by wear and corrosion processes taking place in the oral cavity. Most of the retrieved studies evaluated the wear and corrosion (tribocorrosion) of titanium-based materials used for implants and abutments in artificial saliva...
June 14, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/28611362/zinc-modified-calcium-silicate-coatings-promote-osteogenic-differentiation-through-tgf-%C3%AE-smad-pathway-and-osseointegration-in-osteopenic-rabbits
#10
Jiangming Yu, Lizhang Xu, Kai Li, Ning Xie, Yanhai Xi, Yang Wang, Xuebin Zheng, Xiongsheng Chen, Meiyan Wang, Xiaojian Ye
Surface-modified metal implants incorporating different ions have been employed in the biomedical field as bioactive dental implants with good osseointegration properties. However, the molecular mechanism through which surface coatings exert the biological activity is not fully understood, and the effects have been difficult to achieve, especially in the osteopenic bone. In this study, We examined the effect of zinc-modified calcium silicate coatings with two different Zn contents to induce osteogenic differentiation of rat bone marrow-derived pericytes (BM-PCs) and osteogenetic efficiency in ovariectomised rabbits...
June 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28609500/morphometric-changes-induced-by-cold-argon-plasma-treatment-on-osteoblasts-grown-on-different-dental-implant-surfaces
#11
Luigi Canullo, Tullio Genova, Pietro Mandracci, Federico Mussano, Roberto Abundo, Joseph P Fiorellini
Treatments for enhancing surface energy were studied in an effort to create a more favorable environment for cell adhesion. Cold argon plasma (CAP) is able to improve titanium-cell contact, producing hydrophilic surfaces with higher wettability. The aim of this in vitro study was to estimate the early cell morphology after CAP treatment of different commercially available titanium surfaces. Surface wettability was significantly augmented in all the treated samples. The authors investigated how CAP affected the behavior of osteoblasts by evaluating the cell morphology outcome...
July 2017: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/28587722/comparative-evaluation-of-topographical-data-of-dental-implant-surfaces-applying-optical-interferometry-and-scanning-electron-microscopy
#12
N Kournetas, S Spintzyk, E Schweizer, T Sawada, F Said, P Schmid, J Geis-Gerstorfer, G Eliades, F Rupp
OBJECTIVE: Comparability of topographical data of implant surfaces in literature is low and their clinical relevance often equivocal. The aim of this study was to investigate the ability of scanning electron microscopy and optical interferometry to assess statistically similar 3-dimensional roughness parameter results and to evaluate these data based on predefined criteria regarded relevant for a favorable biological response. METHODS: Four different commercial dental screw-type implants (NanoTite Certain Prevail, TiUnite Brånemark Mk III, XiVE S Plus and SLA Standard Plus) were analyzed by stereo scanning electron microscopy and white light interferometry...
June 3, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28585142/new-mini-dental-implant-attachments-versus-o-ring-attachment-after-cyclic-aging-analysis-of-retention-strength-and-gap-space
#13
Abdalbseet A Fatalla, Ke Song, Ying-Guang Cao
Overdenture as a treatment modality for both partially and fully edentulous patients is costeffective and less expensive. The purpose of the present study was to examine the newly fabricated attachments by comparing them with conventional O-ring attachment in vitro in terms of retention force and cyclic aging resistance. A total of 150 samples were prepared and divided into five groups according to the materials used (O-ring attachment, Deflex M10 XR, Deflex Classic SR, Deflex Acrilato FD, and flexible acrylic resin)...
June 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/28581693/a-prospective-clinical-trial-to-assess-the-optical-efficacy-of-pink-neck-implants-and-pink-abutments-on-soft-tissue-esthetics
#14
Mindy S Gil, Shigemi Ishikawa-Nagai, Hawazin W Elani, John D Da Silva, David M Kim, Dennis Tarnow, Ulrike Schulze-Späte, Nurit Bittner
OBJECTIVE: The purpose of this prospective, randomized, controlled, multicenter clinical study was to analyze the optical effects of an anodized pink colored implant shoulder/abutment system in the peri-implant mucosa of immediately placed dental implants. MATERIALS AND METHOD: Forty subjects with a restoratively hopeless tooth in the maxillary esthetic zone, were recruited and randomized to receive either a pink-neck implant, or a conventional gray implant. All patients received an immediate implant and immediate provisional and two identical CAD/CAM titanium abutments with different surface colors: pink and gray, and one zirconia all-ceramic crown...
June 5, 2017: Journal of Esthetic and Restorative Dentistry
https://www.readbyqxmd.com/read/28576039/investigation-of-the-mechanical-and-chemical-characteristics-of-nanotubular-and-nano-pitted-anodic-films-on-grade-2-titanium-dental-implant-materials
#15
Miklós Weszl, Krisztián László Tóth, Imre Kientzl, Péter Nagy, Dávid Pammer, Liza Pelyhe, Nihal E Vrana, Dieter Scharnweber, Cornelia Wolf-Brandstetter, Árpád Joób F, Eszter Bognár
OBJECTIVE: The objective of this study was to investigate the reproducibility, mechanical integrity, surface characteristics and corrosion behavior of nanotubular (NT) titanium oxide arrays in comparison with a novel nano-pitted (NP) anodic film. METHODS: Surface treatment processes were developed to grow homogenous NT and NP anodic films on the surface of grade 2 titanium discs and dental implants. The effect of process parameters on the surface characteristics and reproducibility of the anodic films was investigated and optimized...
September 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28576014/surface-characteristics-of-bioactive-ti-fabricated-by-chemical-treatment-for-cartilaginous-integration
#16
Hiroyuki Miyajima, Fusun Ozer, Satoshi Imazato, Francis K Mante
Artificial hip joints are generally expected to fail due to wear after approximately 15years and then have to be replaced by revision surgery. If articular cartilage can be integrated onto the articular surfaces of artificial joints in the same way as osseo-integration of titanium dental implants, the wear of joint implants may be reduced or prevented. However, very few studies have focused on the relationship between Ti surface and cartilage. To explore the possibility of cartilaginous-integration, we fabricated chemically treated Ti surfaces with H2O2/HCl, collagen type II and SBF, respectively...
September 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28575965/a-review-of-biocompatible-metal-injection-moulding-process-parameters-for-biomedical-applications
#17
REVIEW
M F F A Hamidi, W S W Harun, M Samykano, S A C Ghani, Z Ghazalli, F Ahmad, A B Sulong
Biocompatible metals have been revolutionizing the biomedical field, predominantly in human implant applications, where these metals widely used as a substitute to or as function restoration of degenerated tissues or organs. Powder metallurgy techniques, in specific the metal injection moulding (MIM) process, have been employed for the fabrication of controlled porous structures used for dental and orthopaedic surgical implants. The porous metal implant allows bony tissue ingrowth on the implant surface, thereby enhancing fixation and recovery...
September 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28571805/gallium-and-silicon-synergistically-promote-osseointegration-of-dental-implant-in-patients-with-osteoporosis
#18
Jinsong Liu, Zuosu Wu, Hongli He, Kaiyong Cai, Hualin Zhang, Lihua Xu
Over the last few decades, a wide variety of dental implants have been successfully placed in jaw bones to restore tooth function. But major challenges still remain in patients with osteoporosis involving compromised osseointegration, and the therapeutic methods is far from optimism. Gallium can directly inhibit bone osteolysis, prevent bone calcium release and augment bone mass, which makes Ga unique among the potential antiresorptive drugs. Silicon, as an indispensable modulator in bone formation, presents its bone anabolic effects, while reduces, at least doesn't increase, bone resorption...
June 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28567712/cellular-fluid-shear-stress-on-implant-surfaces-establishment-of-a-novel-experimental-set-up
#19
P W Kämmerer, D G E Thiem, A Alshihri, G H Wittstock, R Bader, B Al-Nawas, M O Klein
BACKGROUND: Mechanostimuli of different cells can affect a wide array of cellular and inter-cellular biological processes responsible for dental implant healing. The purpose of this in vitro study was to establish a new test model to create a reproducible flow-induced fluid shear stress (FSS) of osteoblast cells on implant surfaces. METHODS: As FSS effects on osteoblasts are detectable at 10 dyn/cm(2), a custom-made flow chamber was created. Computer-aided verification of circulation processes was performed...
December 2017: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/28566674/a-stability-evaluation-of-a-novel-titanium-dental-implant-interconnected-porous-hydroxyapatite-complex-under-functional-loading-conditions
#20
Kazuya Doi, Takayasu Kubo, Shiho Kajihara, Yusuke Makihara, Hiroshi Oue, Yoshifumi Oki, Vittoria Perrotti, Adriano Piattelli, Yasumasa Akagawa, Kazuhiro Tsuga
The aim of this study was to evaluate the stability of implant/interconnected porous calcium hydroxyapatite complex (implant/IPCHA-complex) under functional loading. Implant/IP-CHA-complexes were placed into the mandibles of four Beagle-Labrador hybrid dogs (complex-group). On the other side, an implant was placed directly (control-group). To subject the loading, the animals were fed a hard diet throughout the loading phase of 5 months. The implant stability quotients (ISQs) and bone implant contact (BIC), and histological evaluations were performed...
May 30, 2017: Dental Materials Journal
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