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https://www.readbyqxmd.com/read/29663594/management-of-adenovirus-infection-in-patients-after-haematopoietic-stem-cell-transplantation-state-of-the-art-and-real-life-current-approach-a-position-statement-on-behalf-of-the-infectious-diseases-working-party-of-the-european-society-of-blood-and-marrow
#1
REVIEW
Prashant Hiwarkar, Karin Kosulin, Simone Cesaro, Malgorzata Mikulska, Jan Styczynski, Robert Wynn, Thomas Lion
The important insights gained over the past years in diagnosis and treatment of invasive adenoviral infections provide new paradigms for the monitoring and clinical management of these life-threatening complications. A meeting was held to discuss and subsequently disseminate the current advances in our understanding of the aetiology/pathogenesis and future treatment options facilitating effective control or prevention of adenovirus-related diseases in the allogeneic haematopoietic stem cell transplant setting...
April 16, 2018: Reviews in Medical Virology
https://www.readbyqxmd.com/read/29663435/monitoring-of-oral-cytomegalovirus-dna-shedding-for-the-prediction-of-viral-dnaemia-in-allogeneic-hematopoietic-stem-cell-transplant-recipients
#2
Tania Pascual, Carlos Solano, Ignacio Torres, Alberto Talaya, Estela Giménez, Víctor Vinuesa, José Luis Piñana, Juan Carlos Hernández-Boluda, Ariadna Pérez, David Navarro
Preemptive antiviral therapy based on detecting cytomegalovirus (CMV) DNAemia above a preestablished threshold is the mainstay strategy for the prevention of CMV disease in allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients; nevertheless, CMV DNAemia, even at low levels, may increase mortality. We investigated whether surveillance of saliva for the presence of CMV DNA may anticipate the occurrence of CMV DNAemia. This was a prospective observational study with 53 consecutively enrolled allo-HSCT recipients...
April 16, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29661787/thromboembolism-in-acute-lymphoblastic-leukemia-results-of-nopho-all2008-protocol-treatment-in-patients-1-45-years
#3
Cecilie Utke Rank, Nina Toft, Ruta Tuckuviene, Kathrine Grell, Ove Juul Nielsen, Thomas Leth Frandsen, Hanne Vibeke Hansen Marquart, Birgitte Klug Albertsen, Ulf Tedgård, Helene Hallböök, Ellen Ruud, Kirsten Brunsvig Jarvis, Petter Quist-Paulsen, Pasi Huttunen, Ulla Wartiovaara-Kautto, Ólafur Gísli Jónsson, Sonata Saulyte Trakymiene, Laimonas Griškevičius, Kadri Saks, Mari Punab, Kjeld Schmiegelow
Thromboembolism frequently occurs during acute lymphoblastic leukemia (ALL) therapy. We prospectively registered thromboembolic events during treatment of 1772 consecutive Nordic/Baltic ALL patients 1-45years treated according to the Nordic Society of Pediatric Hematology and Oncology (NOPHO) ALL2008 protocol (7/2008-4/2017). The 2.5-year cumulative incidence of thromboembolism (N=137) was 7.9% (95% confidence interval (CI) 6.6-9.1); higher in patients ≥10years ( P <.0001). Adjusted hazard ratios (HRa) were associated with greater age (10...
April 16, 2018: Blood
https://www.readbyqxmd.com/read/29656398/impact-of-prolonged-dialysis-prior-to-renal-transplantation
#4
David D Aufhauser, Allison W Peng, Douglas R Murken, Seth J Concors, Peter L Abt, Deirdre Sawinski, Roy D Bloom, Peter P Reese, Matthew H Levine
INTRODUCTION: The new Kidney Allocation System (KAS) prioritizes patients based on date of dialysis initiation or wait-listing, whichever is earlier. We hypothesized that this change would increase transplant rates for patients with prolonged pre-transplant dialysis times (DT) and aimed to assess the impact of prolonged DT on post-transplant outcomes. METHODS: We used United Network for Organ Sharing registry data to assess outcomes for patients added to the renal transplant waitlist from Jan 1 1998 - Dec 31 2010 and patients transplanted from Jan 1 1998 - Dec 3 2012...
April 15, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29643913/hair-dye-poisoning-an-early-intervention
#5
Syed Farrukh Umair, Imrana Amin, Ata Urrehman
The use of hair dye has been emerging worldwide however usage of Paraphenylenediamine (PPD) in making hair dye is generally restricted to underdeveloped and developing countries. In particular, prevalence of accidental and suicidal ingestion is more in low socioeconomic areas. The spectra of hair dye toxicity is wide, however, it presents more commonly with severe angioedema of face and neck leading to respiratory failure, rhabdomyolysis complicating into acute kidney injury, myocarditis and acute liver injury...
January 2018: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29628592/magnesium-sulfate-as-a-preemptive-adjuvant-to-levobupivacaine-for-postoperative-analgesia-in-lower-abdominal-and-pelvic-surgeries-under-epidural-anesthesia-randomized-controlled-trial
#6
Heba Omar
Background: Magnesium (Mg) has been evaluated as an adjuvant to local anesthetics for prolongation of postoperative epidural and intrathecal analgesia but not with epidural levobupivacaine in lower abdominal surgeries. Aim of the Study: The aim of the study was to evaluate the preemptive analgesic effect of Mg added to epidural levobupivacaine anesthesia in infraumbilical abdominal surgeries. Settings and Design: This study design was a prospective randomized controlled trial...
January 2018: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29610831/association-of-hla-a-31-01-screening-with-the-incidence-of-carbamazepine-induced-cutaneous-adverse-reactions-in-a-japanese-population
#7
Taisei Mushiroda, Yukitoshi Takahashi, Teiichi Onuma, Yoshiaki Yamamoto, Tetsumasa Kamei, Tohru Hoshida, Katsuya Takeuchi, Kotaro Otsuka, Mitsutoshi Okazaki, Masako Watanabe, Kosuke Kanemoto, Tomohiro Oshima, Atsushi Watanabe, Shiro Minami, Kayoko Saito, Hisashi Tanii, Yasushi Shimo, Minoru Hara, Shinji Saitoh, Toshihiko Kinoshita, Masaki Kato, Naoto Yamada, Naoki Akamatsu, Toshihiko Fukuchi, Shigenobu Ishida, Shingo Yasumoto, Atsushi Takahashi, Takeshi Ozeki, Takahisa Furuta, Yoshiro Saito, Nobuyuki Izumida, Yoko Kano, Tetsuo Shiohara, Michiaki Kubo
Importance: Carbamazepine, a commonly used antiepileptic drug, is one of the most common causes of cutaneous adverse drug reactions (cADRs) worldwide. The allele HLA-A*31:01 is reportedly associated with carbamazepine-induced cADRs in Japanese and European populations; however, the clinical utility of HLA-A*31:01 has not been evaluated. Objective: To assess the use of HLA-A*31:01 genetic screening to identify Japanese individuals at risk of carbamazepine-induced cADRs...
April 2, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29610167/-hla-a-31-01-and-oxcarbazepine-induced-dress-in-a-patient-with-seizures-and-complete-dcx-deletion
#8
Hyun Kim, Laura Chadwick, Yasir Alzaidi, Jonathan Picker, Annapurna Poduri, Shannon Manzi
Oxcarbazepine is an antiepileptic drug (AED) commonly used as a first-line treatment option for focal epilepsy. Several AEDs, including carbamazepine, oxcarbazepine, and phenytoin are associated with various delayed-hypersensitivity reactions such as drug reaction with eosinophilia and systemic symptoms, Stevens-Johnson syndrome, or toxic epidermal necrolysis. The Food and Drug Administration-approved label for oxcarbazepine currently presents information regarding a pharmacogenomic association with the HLA antigen allele HLA-B*15:02 and hypersensitivity reactions in certain ancestry groups with a high incidence of this allele...
April 2018: Pediatrics
https://www.readbyqxmd.com/read/29607849/from-birth-till-palatoplasty-prosthetic-procedural-limitations-and-safeguarding-infants-with-palatal-cleft
#9
Sudhir Bhandari, Bhavita Wadhwa Soni, Shiv Sajan Saini
The most imminent issue to be addressed in a child born with cleft lip and/or palate is restoration of normal feeding. Early surgical treatment for cleft repair is crucial but may need to be postponed until certain age and weight gain is attained in an infant. When other feeding interventions fail in these children, prosthetic obturation of the defect with feeding instructions in the interim period is indicated to ward off the prevailing concerns. However, the entire prosthetic management presents a significant challenge with respect to the child's age, scope of iatrogenic injury to the delicate oral tissues, and potential for life-threatening situation during the procedures...
January 2018: Journal of the Indian Society of Pedodontics and Preventive Dentistry
https://www.readbyqxmd.com/read/29607226/prevention-of-high-dose-cytosine-arabinoside-induced-acute-pericarditis-with-preemptive-dexamethasone-administration-a-case-report-and-literature-review
#10
Weerapat Owattanapanich, Theera Ruchutrakool
Pericarditis/pericardial effusion (PC/PEEF) is a rare but fatal complication of cytosine arabinoside (Ara-C). We report an acute myeloid leukemia (AML) patient who developed massive pericardial effusion after a second Ara-C exposure. As Ara-C was most beneficial in controlling the leukemia, she was treated with a further cycle of Ara-C along with dexamethasone to prevent the complication from reoccurring. No PC/PEEF was subsequently detected.
2018: Case Reports in Hematology
https://www.readbyqxmd.com/read/29606527/a-comparison-of-international-drunk-driving-policies-and-the-role-of-drinking-patterns
#11
Wan-Ju Cheng, Li-Chung Pien
INTRODUCTION: Effective drunk-driving policies are not adopted consistently in many countries. To understand how drinking behaviors influence national drunk-driving policymaking, the associations between drunk-driving policies and country-level drinking volumes and patterns were examined. METHODS: Data for 194 countries were obtained from the WHO 2012 Global Information System on Alcohol and Health. Country-level drinking behaviors were measured using average drinking volumes and patterns of drinking scores based on six attributes of risky drinking...
March 29, 2018: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29603644/racial-ethnic-disparities-in-waitlisting-for-deceased-donor-kidney-transplantation-one-year-after-implementation-of-the-new-national-kidney-allocation-system
#12
Xingyu Zhang, Taylor A Melanson, Laura C Plantinga, Mohua Basu, Stephen O Pastan, Sumit Mohan, David H Howard, Jason M Hockenberry, Michael D Garber, Rachel E Patzer
The impact of a new national kidney allocation system (KAS) on access to the national deceased-donor waiting list (waitlisting) and racial/ethnic disparities in waitlisting among U.S. end stage renal disease (ESRD) patients is unknown. We examined waitlisting pre- and post-KAS among incident (N=1,253,100) and prevalent (N=1,556,954) ESRD patients from the United States Renal Data System database (2005-2015) using multivariable time-dependent Cox and interrupted time-series models. The adjusted waitlisting rate among incident patients was 9% lower post-KAS (HR: 0...
March 30, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29603543/clinical-significance-of-post-prophylaxis-cytomegalovirus-infection-in-lung-transplant-recipients
#13
Nikta Jaamei, Angela Koutsokera, Jérôme Pasquier, Matteo Mombelli, Pascal Meylan, Manuel Pascual, John-David Aubert, Oriol Manuel
BACKGROUND: Cytomegalovirus (CMV) disease has been associated with the development of chronic lung allograft dysfunction (CLAD) after transplantation. However, the relevance of CMV replication occurring after the discontinuation of antiviral prophylaxis on the development of CLAD has not been fully established. METHODS: Patients who underwent lung transplantation during 2004-2014 were included. All patients received antiviral prophylaxis for 3-6 months, followed by monitoring of CMV replication during the first year post-transplantation (preemptive therapy)...
March 30, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29598954/clinical-outcomes-and-prognostic-factors-in-cisplatin-versus-cetuximab-chemoradiation-for-locally-advanced-p16-positive-oropharyngeal-carcinoma
#14
Christian L Barney, Steve Walston, Pedro Zamora, Erin H Healy, Nicole Nolan, Virginia M Diavolitsis, Anterpreet Neki, Robert Rupert, Panos Savvides, Amit Agrawal, Matthew Old, Enver Ozer, Ricardo Carrau, Stephen Kang, James Rocco, Theodoros Teknos, John C Grecula, Jessica Wobb, Darrion Mitchell, Dukagjin Blakaj, Aashish D Bhatt
OBJECTIVES: Randomized trials evaluating cisplatin versus cetuximab chemoradiation (CRT) for p16+ oropharyngeal cancer (OPC) have yet to report preliminary data. Meanwhile, as a preemptive step toward morbidity reduction, the off-trial use of cetuximab in p16+ patients is increasing, even in those who could potentially tolerate cisplatin. The purpose of this study was to compare the efficacy of cisplatin versus cetuximab CRT in the treatment of p16+ OPC and to identify prognostic factors and predictors of tumor response...
April 2018: Oral Oncology
https://www.readbyqxmd.com/read/29598842/comparison-of-tramadol-acetaminophen-fixed-dose-combination-tramadol-and-acetaminophen-in-patients-undergoing-ambulatory-arthroscopic-meniscectomy
#15
Filiz Alkaya Solmaz, Emrah Kovalak
OBJECTIVES: Preemptive analgesia is a technique in which analgesics are administered before a surgery to provide better postoperative pain relief with fewer side effects. In this study, we aimed to compare the preemptive efficacy of tramadol/acetaminophen fixed-dose combination, tramadol, and acetaminophen in patients undergoing ambulatory arthroscopic partial meniscectomy. METHODS: We evaluated the patient records of 75 patients who underwent ambulatory arthroscopic partial meniscectomy...
March 26, 2018: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/29593059/quantitative-inference-of-commutability-for-clinical-viral-load-testing
#16
L Tang, Y Su, S Pounds, R T Hayden
Viral load testing is integral to the clinical care of immunocompromised patients, guiding initiation of preemptive therapy and therapeutic endpoints, while allowing assessment of therapeutic response.….
March 28, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29590040/a-liquid-liquid-transition-in-supercooled-aqueous-solution-related-to-the-hda-lda-transition
#17
Sander Woutersen, Bernd Ensing, Michiel Hilbers, Zuofeng Zhao, C Austen Angell
Simulations and theory suggest that the thermodynamic anomalies of water may be related to a phase transition between two supercooled liquid states, but so far this phase transition has not been observed experimentally because of preemptive ice crystallization. We used calorimetry, infrared spectroscopy, and molecular dynamics simulations to investigate a water-rich hydrazinium trifluoroacetate solution in which the local hydrogen bond structure surrounding a water molecule resembles that in neat water at elevated pressure, but which does not crystallize upon cooling...
March 9, 2018: Science
https://www.readbyqxmd.com/read/29584542/toward-decentralized-agrigenomic-surveillance-a-polymerase-chain-reaction-restriction-fragment-length-polymorphism-approach-for-adaptable-and-rapid-detection-of-user-defined-fungal-pathogens-in-potato-crops
#18
Manousos E Kambouris, Yiannis Manoussopoulos, Stavroula Kritikou, Aphroditi Milioni, Spyridon Mantzoukas, Aristea Velegraki
Agrigenomics is one of the emerging focus areas for omics sciences. Yet, agrigenomics differs from medical omics applications such as pharmacogenomics and precision medicine, by virtue of vastly distributed geography of applications at the intersection of agriculture, nutrition, and genomics research streams. Crucially, agrigenomics can address diagnostics and safety surveillance needs in remote and rural farming communities or decentralized food, crop, and environmental monitoring programs for prompt, selective, and differential identification of pathogens...
March 27, 2018: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/29579856/resistant-cytomegalovirus-infection-after-renal-transplantation-literature-review
#19
M Cintra-Cabrera, A Suárez-Benjumea, G Bernal-Blanco, F M González-Roncero, N G Toapanta-Gaibor, M Súñer-Poblet, M Á Pérez-Valdivia, F Fernández-Cuenca, M Á Gentil-Govantes, J L Rocha-Castilla
BACKGROUND: Resistant cytomegalovirus (R-CMV) is an emerging problem in the renal transplantation population. The most frequent CMVs are high-resistance mutations (UL97 gene). METHODS: We describe our experience in management of R-CMV after renal transplant at our center (2012-2016). RESULTS: We encountered 3 cases of R-CMV infection after renal transplant (all primary infections). All 3 patients received induction therapy with corticosteroids, tacrolimus, and mycophenolate mofetil...
March 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29579221/prolonged-dialysis-duration-is-associated-with-graft-failure-and-mortality-after-kidney-transplantation-results-from-the-french-transplant-database
#20
Mathilde Prezelin-Reydit, Christian Combe, Jérôme Harambat, Christian Jacquelinet, Pierre Merville, Lionel Couzi, Karen Leffondré
Background: Kidney transplantation (KT) is the treatment of choice for end-stage renal disease. Preemptive KT (PKT) should be considered when glomerular filtration rate is <15 mL/min/1.73 m2 but European reports on the results of PKT and the effect of pretransplant dialysis are scarce. Methods: We analysed all first kidney-only transplants performed in adults in France between 2002 and 2012. A Cox multivariable model was used to investigate the association of PKT and of pretransplant dialysis time with the hazard of graft failure defined as death, return to dialysis or retransplant, whichever occurred first...
March 22, 2018: Nephrology, Dialysis, Transplantation
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