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https://www.readbyqxmd.com/read/29454474/cardiovascular-pulmonary-and-metabolic-toxicities-complicating-tyrosine-kinase-inhibitor-therapy-in-chronic-myeloid-leukemia-strategies-for-monitoring-detecting-and-managing
#1
REVIEW
Bruno C Medeiros, Jennifer Possick, Michael Fradley
Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm, the incidence of which increases with age. Tyrosine kinase inhibitors (TKIs) are the mainstay of CML treatment, including imatinib, nilotinib, dasatinib, bosutinib, and ponatinib. Beyond matching patient disease profiles with TKI specificity, differences in the efficacy and toxicity profiles and a patient's comorbid risk factors should be considered when selecting the most appropriate agent. Our objectives are to review the incidence and severity of cardiovascular, metabolic, and pulmonary disorders associated with these TKIs, highlighting differences in adverse event profiles, suggested risk-mitigation strategies, and guidance for TKI selection in different settings...
February 3, 2018: Blood Reviews
https://www.readbyqxmd.com/read/29453853/role-of-bi-weekly-serum-galactomannan-screening-for-the-diagnosis-of-invasive-aspergillosis-in-hematologic-cancer-patients
#2
Jade Couchepin, Anne-Sophie Brunel, Katia Jaton, Pascal Meylan, Pierre-Yves Bochud, Frédéric Lamoth
Invasive aspergillosis (IA) is a life-threatening infection affecting hematologic cancer patients with chemotherapy-induced neutropenia. The diagnosis of IA often relies on the detection of galactomannan (GM) in serum or bronchoalveolar lavage fluid (BAL). Bi-weekly serum GM screening has been proposed for a preemptive therapeutic approach of IA in patients not receiving mold-active prophylaxis. We have analyzed all IA cases among patients with hematologic malignancies and prolonged chemotherapy-induced neutropenia (>14 days) in our institution over a 10-year period (2007-2017)...
February 17, 2018: Mycoses
https://www.readbyqxmd.com/read/29445770/subthalamic-neural-activity-patterns-anticipate-economic-risk-decisions-in-gambling
#3
A Mazzoni, M Rosa, J Carpaneto, L M Romito, A Priori, S Micera
Economic decision-making is disrupted in individuals with gambling disorder, an addictive behavior observed in Parkinson's disease (PD) patients receiving dopaminergic therapy. The subthalamic nucleus (STN) is involved in the inhibition of impulsive behaviors; however, its role in impulse control disorders and addiction is still unclear. Here, we recorded STN local field potentials (LFPs) in PD patients with and without gambling disorder during an economic decision-making task. Reaction times analysis showed that for all patients, the decision whether to risk preceded task onset...
January 2018: ENeuro
https://www.readbyqxmd.com/read/29428484/pre-transplant-screening-for-non-hla-antibodies-who-should-be-tested
#4
Mary Carmelle Philogene, Sheng Zhou, Bonnie E Lonze, Serena Bagnasco, Sami Alasfar, Robert A Montgomery, Edward Kraus, Annette M Jackson, Mary S Leffell, Andrea A Zachary
Retrospective studies of angiotensin II type 1 receptor antibodies (AT1R-Ab) and anti-endothelial cell antibodies (AECA) have linked these antibodies to allograft injury. Because rising healthcare costs dictate judicious use of laboratory testing, we sought to define characteristics of kidney transplant recipients who may benefit from screening for non-HLA antibodies. Kidney recipients transplanted between 2011 and 2016 at Johns Hopkins, were evaluated for AT1R-Ab and AECA. Pre-transplant antibody levels were compared to clinical and biopsy indications of graft dysfunction...
February 8, 2018: Human Immunology
https://www.readbyqxmd.com/read/29412363/preemptive-use-of-etodolac-on-tooth-sensitivity-after-in-office-bleaching-a-randomized-clinical-trial
#5
Savil Costa Vaez, André Luís Faria-E-Silva, Alessandro Dourado Loguércio, Micaelle Tenório Guedes Fernandes, Flávia Pardo Salata Nahsan
This study determined the effectiveness of the preemptive administration of etodolac on risk and intensity of tooth sensitivity and the bleaching effect caused by in-office bleaching using 35% hydrogen peroxide. Fifty patients were selected for this tripleblind, randomized, crossover, and placebo-controlled clinical trial. Etodolac (400 mg) or placebo was administrated in a single-dose 1 hour prior to the bleaching procedure. The whitening treatment with 35% hydrogen peroxide was carried out in two sessions with a 7-day interval...
February 1, 2018: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/29409382/distal-placement-of-resuscitative-endovascular-balloon-occlusion-of-the-aorta-reboa-to-restore-hemodynamic-stability-in-a-patient-with-proximal-aortic-rupture
#6
Shira Strauss, Paul Engels, John Harlock
PURPOSE: To report unconventional use of the resuscitative endovascular balloon occlusion of the aorta (REBOA) technique to restore hemodynamic stability in a patient who was hemorrhaging from aortic injury proximal to the target zone of occlusion. CASE REPORT: A 72-year-old woman underwent urgent thoracic stent-graft repair of a ruptured 8×8-cm mycotic pseudoaneurysm. Two months later, follow-up imaging revealed that the proximal aortic stent seal zone had degenerated, so a percutaneous procedure was performed 2 months later to preemptively reinforce the segment of stented aorta...
February 1, 2018: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/29407331/safety-and-efficacy-of-induction-therapy-with-thymoglobulin-in-ab0-incompatible-kidney-transplantation
#7
A L Herzog, C Kalogirou, C Wanner, K Lopau
INTRODUCTION: Data suggest an additional role of T cells in antibody-mediated rejections. In 2001 a protocol for AB0-incompatible kidney transplantation based on B-cell-depleting anti-CD20 antibody rituximab, antigen-specific blood group IgG immunoadsorption, intravenous immunoglobulins, and triple immunosuppression was introduced in Europe, which used induction therapy with the use of interleukin-2 receptor antibody (IL2-RA) basiliximab. We used thymoglobulin in AB0-incompatible patients as induction in the face of high immunologic risk...
January 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29404791/chronification-of-pain-mechanisms-current-understanding-and-clinical-implications
#8
REVIEW
Daniel J Pak, R Jason Yong, Alan David Kaye, Richard D Urman
PURPOSE OF REVIEW: The development of acute to chronic pain involves distinct pathophysiological changes in the peripheral and central nervous systems. This article reviews the mechanisms, etiologies, and management of chronic pain syndromes with updates from recent findings in the literature. RECENT FINDINGS: Chronic post-surgical pain (CPSP) is not limited to major surgeries and can develop after smaller procedures such as hernia repairs. While nerve injury has traditionally been thought to be the culprit for CPSP, it is evident that nerve-sparing surgical techniques are not completely preventative...
February 5, 2018: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/29399926/the-choice-between-deceased-vs-living-donor-renal-transplantation-in-children-analysis-of-data-from-a-belgian-tertiary-center
#9
Katty Van Cauwenberghe, Ann Raes, Lut Pauwels, Jo Dehoorne, Luc Colenbie, Clement Dequidt, Lien Dossche, Johan Vande Walle, Agnieszka Prytuła
Pediatric renal transplantation with a living donor (LD) has superior outcome, but there is a paucity of studies analyzing the reasons for not undertaking living donation in West-European countries. The aim of this study was to retrospectively review the choice of donor source in our center. We also aimed to identify factors which prevented transplantation with a LD. This retrospective study was performed including children aged 2-19 years who underwent kidney transplantation (KT) at the Ghent University Hospital between 1996 and 2016...
February 4, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29397926/bronchial-mismatch-as-a-predictor-of-respiratory-failure-after-congenital-tracheal-stenosis-repair
#10
Enrico Cetrano, Matteo Trezzi, Aurelio Secinaro, Luca Di Chiara, Marilena Trozzi, Sergio Bottero, Angelo Polito, Adriano Carotti
BACKGROUND: The purpose of this study was to identify predictors of postoperative respiratory failure after surgical tracheoplasty for congenital tracheal stenosis. METHODS: Between February 2011 and April 2017, 16 infants underwent congenital tracheal stenosis repair. Preoperative computed tomography evaluation of the trachea and mainstem bronchi was performed. The primary outcome was midterm freedom from postoperative respiratory failure defined as persistent need for mechanical ventilation or surgical tracheobronchial reoperation...
February 1, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29389938/skill-or-lack-thereof-of-data-model-fusion-techniques-to-provide-an-early-warning-signal-for-an-approaching-tipping-point
#11
Riddhi Singh, Julianne D Quinn, Patrick M Reed, Klaus Keller
Many coupled human-natural systems have the potential to exhibit a highly nonlinear threshold response to external forcings resulting in fast transitions to undesirable states (such as eutrophication in a lake). Often, there are considerable uncertainties that make identifying the threshold challenging. Thus, rapid learning is critical for guiding management actions to avoid abrupt transitions. Here, we adopt the shallow lake problem as a test case to compare the performance of four common data assimilation schemes to predict an approaching transition...
2018: PloS One
https://www.readbyqxmd.com/read/29388290/the-effect-of-peri-transplant-plasmapheresis-in-the-prevention-of-recurrent-fsgs
#12
P S Verghese, M N Rheault, S Jackson, A J Matas, S Chinnakotla, B Chavers
Many pediatric centers utilize a variety of protocols including preemptive plasmapheresis to prevent the recurrence of FSGS post-transplant. But the effectiveness of this expensive, time-consuming process of plasmapheresis in the prevention of FSGS recurrence is still unclear. We retrospectively reviewed all pediatric cases of FSGS in our center that received a kidney transplant and compared the transplant and patient outcomes of those transplanted after 2006 who received pretransplant plasmapheresis to those prior to 2006 who did not...
February 1, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29375884/implementation-and-evaluation-of-a-risk-based-approach-to-guide-chronic-kidney-disease-care-protocol-for-a-multiphase-mixed-methods-study
#13
Brenda R Hemmelgarn, Michelle D Smekal, Robert G Weaver, Chandra Thomas, Eleanor Benterud, Kin Tam, Braden J Manns, Marcello Tonelli, Juli Finlay, Maoliosa Donald, Helen Tam-Tham, Aminu Bello, Navdeep Tangri, Robert R Quinn
Background: Risk prediction tools are used in a variety of clinical settings to guide patient care, although their use in chronic kidney disease (CKD) care is limited. Objectives: To assess the association of a risk-based model of CKD care on patient care, satisfaction, outcomes, and cost. Design: Mixed-methods with a pre-post design. Setting: We will use mixed-methods and a pre-post design to evaluate use of the Kidney Failure Risk Equation (KFRE) to guide CKD care...
2018: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/29375067/mediative-fluency-and-futility-disputes
#14
Samantha F Knowlton, Joseph J Fins
Futility disputes are more likely to be resolved-and relational breaches repaired-by engaging in a process that fosters communication between clinicians, patients, and families. This essay calls for mediative fluency. The preemptive use of a futility definition can stifle conversation when it is needed most, exacerbating the very power imbalances and associated health disparities that often precipitate futility disputes. When clinicians, patients, and families engage in dialogue, clinicians can appreciate what motivates requests for what is thought to be futile care, and patients and families can better understand the limits of available therapies...
2018: Perspectives in Biology and Medicine
https://www.readbyqxmd.com/read/29374855/children-on-dialysis-as-well-as-renal-transplanted-children-report-severely-impaired-health-related-quality-of-life
#15
Anouck Splinter, Lidwien A Tjaden, Lotte Haverman, Brigitte Adams, Laure Collard, Karlien Cransberg, Maria van Dyck, Koen J Van Hoeck, Bernd Hoppe, Linda Koster-Kamphuis, Marc R Lilien, Ann Raes, Christina Taylan, Martha A Grootenhuis, Jaap W Groothoff
OBJECTIVES: To assess health-related quality of life (HRQoL) across three renal replacement therapy modalities (preemptive transplant, non-preemptive transplant, and dialysis) in comparison with the healthy norm and other chronic health conditions, and to explore related patient factors. STUDY DESIGN: All prevalent end-stage renal disease (ESRD) patients aged 8-18 years who spent at least 6 months on their current treatment modality in the Netherlands, Belgium, and part of Germany were approached to complete the Pediatric Quality of Life Inventory 4...
January 27, 2018: Quality of Life Research
https://www.readbyqxmd.com/read/29373687/substituting-abacavir-for-stavudine-in-children-who-are-virally-suppressed-without-lipodystrophy-randomized-clinical-trial-in-johannesburg-south-africa
#16
Renate Strehlau, Stephanie Shiau, Stephen Arpadi, Faeezah Patel, Francoise Pinillos, Wei-Yann Tsai, Ashraf Coovadia, Elaine Abrams, Louise Kuhn
Objectives. : Abacavir has replaced stavudine in antiretroviral therapy (ART) regimens because it has largely been phased out as a result of toxicity concerns; this loss has reduced further the already-limited drug options for children. Few data regarding virologic and metabolic outcomes among children who undergo substitution of stavudine exist. We evaluated the effects of preemptive substitution of abacavir for stavudine in children initially without lipodystrophy and virally suppressed on a stavudine-containing regimen...
January 24, 2018: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29372128/ticking-bomb-asymptomatic-mirizzi-syndrome
#17
Stella Pak, Damian Valencia, Brendan Sheehy, Uchenna Agbim, Yusuf Askaroglu, Christine Dee
Mirizzi syndrome, also known as extrinsic biliary compression syndrome, is a rare clinical entity in which the common bile duct is obstructed by compression by the impaction of one or more gallstones in the cystic duct or gallbladder infundibulum. This case illustrates an absolutely asymptomatic presentation of Mirizzi syndrome in a 62-year-old, otherwise healthy, woman. Mirizzi syndrome was treated with preemptive laparotomy cholecystectomy. The present case is exemplary for careful evaluation with the proper index of suspicion in establishment of preoperative diagnosis as well as prompt treatment prior to development of complications...
November 16, 2017: Curēus
https://www.readbyqxmd.com/read/29360287/percutaneous-perfusion-monitoring-for-the-detection-of-hemodialysis-induced-cardiovascular-injury
#18
Jarrin D Penny, Claire Grant, Fabio Salerno, Anne Brumfield, Marcus Mianulli, Lori Poole, Christopher W Mcintyre
INTRODUCTION: The safe delivery of hemodialysis (HD) faces dual challenges; the accurate detection of systemic circulatory stress producing cardiovascular (CV) injury, and the ability to enable effective preemptive intervention for such injury. We performed a pilot study to examine the capability of a new noninvasive, real-time monitoring system to detect the deleterious effects of HD on CV stability. METHODS: Eight patients were evaluated with echocardiography prior to the initiation of HD and again at peak HD stress...
January 23, 2018: Hemodialysis International
https://www.readbyqxmd.com/read/29353426/is-dipyrone-effective-as-a-preemptive-analgesic-in-third-molar-surgery-a-pilot-study
#19
Vinícius Tatsumoto Favarini, Carlos Alysson Aragão Lima, Rogério Almeida da Silva, Fábio Ricardo Loureiro Sato
PURPOSE: Studies on preemptive analgesia in maxillofacial surgery have shown several controversial clinical results, mainly due to the absence of a methodological standard, besides a wide variety of studied drugs. This study intended to answer the following hypothesis: Is the administration of dipyrone preemptively capable of decreasing trans- and postoperative pain in the third molar surgical extraction? METHODS: A pilot prospective double-blind placebo-controlled study was carried out with 25 patients submitted to the third molar surgical extraction at two moments, one side in each intervention...
January 20, 2018: Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29351773/treatment-of-long-segment-barrett-s-adenocarcinoma-by-complete-circular-endoscopic-submucosal-dissection-a-case-report
#20
Miki Kaneko, Akira Mitoro, Motoyuki Yoshida, Masayoshi Sawai, Yasushi Okura, Masanori Furukawa, Tadashi Namisaki, Kei Moriya, Takemi Akahane, Hideto Kawaratani, Mitsuteru Kitade, Kousuke Kaji, Hiroaki Takaya, Yasuhiko Sawada, Kenichiro Seki, Shinya Sato, Tomomi Fujii, Junichi Yamao, Chiho Obayashi, Hitoshi Yoshiji
BACKGROUND: We present the first description of en bloc endoscopic submucosal dissection (ESD) for total circumferential Barrett's adenocarcinoma, predominantly of the long-segment Barrett's esophagus (LSBE), with a 2-year follow-up and management strategies for esophageal stricture prevention. CASE PRESENTATION: A 59-year-old man was diagnosed with LSBE and Barrett's adenocarcinoma by esophagogastroduodenoscopy (EGD). A 55-mm-long circumferential tumor was completely resected by ESD...
January 19, 2018: BMC Gastroenterology
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