keyword
MENU ▼
Read by QxMD icon Read
search

Preemptive

keyword
https://www.readbyqxmd.com/read/28231491/effect-of-granulocyte-colony-stimulating-factor-on-outcomes-in-patients-with-non-m3-acute-myelogenous-leukemia-treated-with-anthracycline-based-induction-7-3-regimen-chemotherapies
#1
Ka-Won Kang, Dae Sik Kim, Se Ryeon Lee, Hwa Jung Sung, Seok Jin Kim, Chul Won Choi, Byung Soo Kim, Yong Park
We analyzed the effects of granulocyte colony-stimulating factor (G-CSF) on outcomes in 315 anthracycline-based induction chemotherapy-treated patients with non-M3 acute myelogenous leukemia (AML). Patients were classified as follows: no G-CSF administration during induction (no G-CSF group; 112 patients); administration immediately upon neutropenia onset (absolute neutrophil counts (ANC)<1000/μL), but before febrile neutropenia (preemptive group; 74 patients); and administration following febrile neutropenia development (therapeutic group; 129 patients)...
February 8, 2017: Leukemia Research
https://www.readbyqxmd.com/read/28225506/effects-of-single-dose-preemptive-intravenous-ibuprofen-on-postoperative-opioid-consumption-and-acute-pain-after-laparoscopic-cholecystectomy
#2
Elif Oral Ahiskalioglu, Ali Ahiskalioglu, Pelin Aydin, Ahmet Murat Yayik, Ayetullah Temiz
BACKGROUND: Although studies involving intravenous (IV) ibuprofen are still limited, it has been shown to have a potential role in the treatment of postoperative pain. The primary objective of this study was to investigate the effects of preemptive IV ibuprofen on postoperative 24 hour opioid consumption and postoperative pain in patients undergoing laparoscopic cholecystectomy. METHODS: Following ethical committee approval, 60 patients aged 18 to 65, American Society of Anesthesiology (ASA) I-II, and scheduled for laparoscopic cholecystectomy were included in this prospective, randomized, double-blinded study...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28222898/strategies-for-the-optimal-timing-to-start-renal-replacement-therapy-in-critically-ill-patients-with-acute-kidney-injury
#3
REVIEW
Sean M Bagshaw, Ron Wald
Renal replacement therapy (RRT) is increasingly utilized to support critically ill patients with severe acute kidney injury (AKI). The question of whether and when to start RRT for a critically ill patient with AKI has long troubled clinicians. When severe complications of AKI develop, the need to commence RRT is unambiguous. In the absence of such complications but in the presence of severe AKI, the optimal time and thresholds for starting RRT are uncertain. The majority of existing data have largely been derived from observational studies...
February 17, 2017: Kidney International
https://www.readbyqxmd.com/read/28213926/association-of-hypercalcemia-before-treatment-with-hypocalcemia-after-treated-in-dogs-with-primary-hyperparathyroidism
#4
J D Dear, P H Kass, A M Della Maggiore, E C Feldman
BACKGROUND: Development of hypocalcemia after treatment of hyperparathyroidism results in increased costs and risk of poorer outcomes. Previous studies have shown conflicting data about predictors of hypocalcemia after these procedures. HYPOTHESIS/OBJECTIVES: The objective of this study was to investigate whether ionized calcium (iCa) concentrations before treatment are predictive of hypocalcemia or its clinical signs after surgical removal or heat ablation in dogs with primary hyperparathyroidism...
February 18, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28213007/effect-of-dasatinib-on-emt-mediated-mechanism-of-resistance-against-egfr-inhibitors-in-lung-cancer-cells
#5
Yuichi Sesumi, Kenichi Suda, Hiroshi Mizuuchi, Yoshihisa Kobayashi, Katsuaki Sato, Masato Chiba, Masaki Shimoji, Kenji Tomizawa, Toshiki Takemoto, Tetsuya Mitsudomi
OBJECTIVE: The epithelial to mesenchymal transition (EMT) is associated with acquired resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in certain non-small cell lung cancers that harbor EGFR mutations. Because no currently available drugs specifically kill cancer cells via EMT, novel treatment strategies that overcome or prevent EMT are needed. A recent report suggested that dasatinib (an ABL/Src kinase inhibitor) inhibits EMT induced by transforming growth factor (TGF)-beta in lung cancer cells (Wilson et al...
February 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28210503/strongyloidiasis-current-status-with-emphasis-in-diagnosis-and-drug-research
#6
REVIEW
Tiago Mendes, Karen Minori, Marlene Ueta, Danilo Ciccone Miguel, Silmara Marques Allegretti
Strongyloidiasis is a parasitic neglected disease caused by the nematode Strongyloides stercoralis affecting 30 to 100 million people worldwide. Complications, strongly associated with alcoholism, organ transplants, and HTLV-1 virus, often arise due to late diagnosis, frequently leading to patient death. Lack of preemptive diagnosis is not the only difficulty when dealing with this parasite, since there are no gold standard diagnostic techniques, and the ones used have problems associated with sensitivity, resulting in false negatives...
2017: Journal of Parasitology Research
https://www.readbyqxmd.com/read/28209110/bilateral-inguinal-hernia-with-an-uncommon-content%C3%A2-a-case-report
#7
L Soydan, H Gündoğdu, A Aslan, I Inan, A O Balık
Here we present a sixty-two year old man with bilateral swellings palpated in inguinal areas on physical examination. Ultrasonography and abdominal multi-detector computed tomography revealed a bladder herniation through the right inguinal canal and a sigmoid colon herniation through the left inguinal canal. Radiologic imaging methods are important and can guide clinicians for preemptive or emergent surgery. (Acta gastroenterol. belg., 2016, 79, 495-496).
September 2016: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/28205327/early-mixed-chimerism-based-preemptive-immunotherapy-in-children-undergoing-allogeneic-hematopoietic-stem-cell-transplantation-for-acute-leukemia
#8
Biljana Horn, Justin T Wahlstrom, Alexis Melton, Angela Liou, Marie Ouachee-Chardin, Gauri Sunkersett, Jennifer Willert, Jimmy Hwang, Jueleah Expose-Spencer, Mort C Cowan, Janelle Facchino, Christopher C Dvorak
This retrospective analysis comprises 10-year experience with early posttransplant mixed chimerism-based preemptive intervention. Out of 104 patients, 51 received preemptive immunotherapy. Their outcomes were similar to patients achieving full donor chimerism spontaneously. Among patients receiving intervention, 5-year event-free survival was identical in patients with and without pretransplant residual disease, respectively (68% [95% confidence interval (CI) 38-98%] vs. 69% [95% CI 54-85%] log-rank = 0.4)...
February 16, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28197031/efficacy-of-preprocedural-diclofenac-in-men-undergoing-double-j-stent-removal-under-local-anesthesia-a-double-blind-randomized-control-trial
#9
Vilvapathy Senguttuvan Karthikeyan, Ramaiah Keshavamurthy, Ashwin Mallya, Manohar Chikka Moga Siddaiah, Sumit Kumar, Chulai Rajabahadhur Chandrashekar
INTRODUCTION: Double J (DJ) stents are often removed under local anesthesia using a rigid cystoscope. Patients experience significant pain during this procedure and also continue to have discomfort during voiding for a few days. We assessed the efficacy and safety of preemptive oral diclofenac in pain relief in patients undergoing DJ stent removal (DJSR) by rigid cystoscopy compared to placebo. METHODS: Consecutive consenting male patients undergoing DJSR under local anesthesia between March 2014 and July 2015 were enrolled...
January 2017: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/28178168/rapid-intracranial-response-to-osimertinib-without-radiotherapy-in-nonsmall-cell-lung-cancer-patients-harboring-the-egfr-t790m-mutation-two-case-reports
#10
Taro Koba, Takashi Kijima, Takayuki Takimoto, Haruhiko Hirata, Yujiro Naito, Masanari Hamaguchi, Tomoyuki Otsuka, Muneyoshi Kuroyama, Izumi Nagatomo, Yoshito Takeda, Hiroshi Kida, Atsushi Kumanogoh
RATIONALE: Most of nonsmall cell lung cancer (NSCLC) patients harboring epidermal growth factor receptor (EGFR) activating mutations eventually acquire resistance to the first EGFR-tyrosine kinase inhibitors (TKIs) therapy after varying periods of treatment. Of note, approximately one-third of those patients develop brain metastases, which deteriorate their quality of life and survival. The effect of systemic chemotherapy on brain metastases after acquisition of EGFR-TKI resistance is limited, and thus far, whole-brain radiation therapy, which may cause the harmful effect on neurocognitive functions, has been the only established therapeutic option for especially symptomatic brain metastases...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28176616/different-courses-of-hepatitis-b-reinfection-after-renal-transplant-a-case-report
#11
Ozan Yegit, Erol Demir, Yasar Caliskan, Halil Yazici, Mehmet Sukru Sever
Hepatitis B surface antigen-positive allografts may be a source of transmission in patients who undergo renal transplantation. Treatment of hepatitis B virus infection with nucleoside/nucleotide analogs in kidney recipients who have hepatitis B virus infection or who have received transplants from hepatitis B surface antigen-positive donors improves long-term patient survival. Antiviral agents are administered as a preemptive or prophylactic therapy at the time of kidney transplantation, rather than as salvage treatment...
February 7, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28174553/intergroup-biases-in-fear-induced-aggression
#12
Nobuhiro Mifune, Dora Simunovic, Toshio Yamagishi
Using a recently created preemptive strike game (PSG) with 176 participants, we investigated if the motivations of spite and/or fear promotes aggression that requires a small cost to the aggressor and imposes a larger cost on the opponent, and confirmed the earlier finding that fear does but spite does not promote intergroup aggression when the groups are characterized as minimal groups; additionally, the rate of intergroup aggression did not vary according to the group membership of the opponent. The PSG represents a situation in which both the motivations of spite and of fear can logically drive players to choose an option of aggression against an opponent...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28166825/the-dynamics-of-runx1-runx1t1-transcript-levels-after-allogeneic-hematopoietic-stem-cell-transplantation-predict-relapse-in-patients-with-t-8-21-acute-myeloid-leukemia
#13
Ya-Zhen Qin, Yu Wang, Lan-Ping Xu, Xiao-Hui Zhang, Huan Chen, Wei Han, Yu-Hong Chen, Feng-Rong Wang, Jing-Zhi Wang, Yao Chen, Xiao-Dong Mo, Xiao-Su Zhao, Ying-Jun Chang, Kai-Yan Liu, Xiao-Jun Huang
BACKGROUND: The optimal monitoring schedules and cutoff minimal residual disease (MRD) levels for the accurate prediction of relapse at all time points after allogeneic hematopoietic stem cell transplantation (allo-HSCT) remain unclear in patients with t(8;21) acute myeloid leukemia (AML). METHODS: RUNX1-RUNX1T1 transcript levels were measured in bone marrow samples collected from 208 patients at scheduled time points after transplantation (1530 samples in total)...
February 6, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28165158/development-and-evaluation-of-a-quantitative-assay-detecting-cytomegalovirus-transcripts-for-preemptive-therapy-in-allogeneic-hematopoietic-stem-cell-transplant-recipients
#14
Keiko Ishii, Yasushi Onishi, Namiko Miyamura, Noriko Fukuhara, Kenichi Ishizawa, Mutsumi Nakanishi, Satoru Ohnaka, Tomomitsu Miyasaka, Emi Kanno, Kazuyoshi Kawakami, Hideo Harigae, Mitsuo Kaku
Successful preemptive therapy for cytomegalovirus (CMV) infection after hematopoietic stem cell transplantation (HSCT) depends on the availability of a rapid and sensitive assay to guide early treatment. Currently, the antigenemia assay and the quantitative real-time PCR (qPCR) assay are widely used for this purpose, but they have distinctive concerns. This study aimed to develop and evaluate a novel CMV diagnostic test based on transcription-reverse transcription concerted reaction (TRC), an RNA-detecting technology...
February 6, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28164310/first-zika-positive-donations-in-the-continental-united-states
#15
Susan A Galel, Phillip C Williamson, Michael P Busch, Danielle Stanek, Sonia Bakkour, Mars Stone, Kai Lu, Scott Jones, Susan N Rossmann, Lisa Lee Pate
BACKGROUND: Zika virus (ZIKV) has spread in the Americas, including parts of the southern United States, and infection can be associated with serious complications, including congenital brain abnormalities. Probable transfusion transmission of ZIKV has been documented in Brazil. STUDY DESIGN AND METHODS: Preemptive testing of blood donations for ZIKV RNA was implemented in southern US states at risk of local transmission using a test approved under a Food and Drug Administration (FDA) investigational new drug application, cobas Zika...
February 5, 2017: Transfusion
https://www.readbyqxmd.com/read/28145625/pediatric-renal-transplant-practices-in-india
#16
Sidharth Kumar Sethi, Rajiv Sinha, Smriti Rohatgi, Vijay Kher, Arpana Iyengar, Arvind Bagga
Limited access to tertiary-level health care, limited trained pediatric nephrologists and transplant physicians, lack of facilities for dialysis, lack of an effective deceased donor program, non-affordability, and non-adherence to immunosuppressant drugs poses a major challenge to universal availability of pediatric transplantation in developing countries. We present the results of a survey which, to the best of our knowledge, is the first such published attempt at understanding the current state of pediatric renal transplantation in India...
February 1, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28137348/defining-procedural-distress-in-the-nicu-and-what-can-be-done-about-it
#17
Martin Schiavenato, Liisa Holsti
Procedural distress is a common occurrence in the NICU and is tied to attempts to support the life and development of vulnerable premature infants. We discuss the epidemiology of procedural distress and the potential negative consequences on infant neurodevelopment. We define procedural distress in the NICU and outline three approaches to limit or to reduce its detrimental effects including minimizing the number of procedures, instituting measures for developmentally supportive care, and using preemptively pharmacologic and nonpharmacologic analgesia...
January 1, 2017: Neonatal Network: NN
https://www.readbyqxmd.com/read/28128059/pharmacogenetics-and-metabolism-from-science-to-implementation-in-clinical-practice-the-example-of-dihydropyrimidine-dehydrogenase
#18
Marzia Del Re, Giuliana Restante, Antonello Di Paolo, Stefania Crucitta, Eleonora Rofi, Romano Danesi
BACKGROUND: Fluoropyrimidines are widely used in the treatment of solid tumors and remain the backbone of many combination chemotherapy regimens. Despite their clinical benefit, they are associated with frequent gastrointestinal and hematological toxicities, which often lead to treatment discontinuation. Fluoropyrimidines undergo complex anabolic and catabolic biotransformation. Enzymes involved in this pathway include dihydropyrimidine dehydrogenase (DPD), which breaks down 5-FU and its prodrugs...
January 25, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28126259/screening-test-recommendations-for-methicillin-resistant-staphylococcus-aureus-surveillance-practices-a-cost-minimization-analysis
#19
Melanie D Whittington, Donna J Curtis, Adam J Atherly, Cathy J Bradley, Richard C Lindrooth, Jonathan D Campbell
BACKGROUND: To mitigate methicillin-resistant Staphylococcus aureus (MRSA) infections, intensive care units (ICUs) conduct surveillance through screening patients upon admission followed by adhering to isolation precautions. Two surveillance approaches commonly implemented are universal preemptive isolation and targeted isolation of only MRSA-positive patients. METHODS: Decision analysis was used to calculate the total cost of universal preemptive isolation and targeted isolation...
January 23, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28110608/reduced-sludge-production-in-a-membrane-bioreactor-by-uncoupling-metabolism-and-its-effect-on-phosphorus-accumulation-in-the-biomass
#20
Ji-Hun Na, Duck-Hyun Nam, Byeong-Gon Ko, Chae-Young Lee, Ki-Hoon Kang
Due to its limited recycling or reuse, treatment and disposal of excess waste activated sludge has been a major challenge. As a preemptive method, therefore, uncoupling metabolism for reduced sludge production has been investigated recently. In this study, we operated a pilot-scale A(2)O-MBR system incorporating an anaerobic sludge holding tank (SHT) in a sludge recycling line to induce uncoupling metabolism, and investigated sludge production and treatment efficiency. After operation for ≥ 1 year, the Yobs value was estimated to be 0...
January 23, 2017: Environmental Technology
keyword
keyword
73897
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"