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https://www.readbyqxmd.com/read/28937299/pediatric-playground-related-injuries-treated-in-hospital-emergency-departments-in-the-united-states
#1
Sarah L Adelson, Thitphalak Chounthirath, Nichole L Hodges, Christy L Collins, Gary A Smith
This study analyzed pediatric playground-related injuries data from the National Electronic Injury Surveillance System. An estimated 5 025 440 children <18 years were treated in US emergency departments for playground-related injuries during 1990-2012, averaging 218 497 children annually. The average patient age was 6.5 years. The overall annual injury rate declined during 1990-2007 ( P < .001) and then increased during 2007-2012 ( P < .001). The climbing equipment-related injury rate remained constant during 1990-2009 and then increased during 2007-2012 ( P = ...
September 1, 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/28936737/peripartum-cardiomyopathy-do-exosomes-play-a-role
#2
Huanyu Gu, Qiying Dai, Zhuyuan Liu, Hongbao Wang, Jianhua Yao, Lei Zhou
Peripartum cardiomyopathy (PPCM) refers to irreversible cardiomyocyte damage that occurs during the last month of pregnancy, or within 5 months after giving birth. It is characterized by systolic heart failure. This life-threatening condition is relatively uncommon, but the incidence has been climbing up. Because of its high mortality, it is crucial for physicians to have high suspicious for the disease. Studies have been done to search into specific lab test and treatment for PPCM. Therapies like anti-viral, anti-inflammatory and immunosuppression regimen have been explored...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28931439/effects-of-whole-body-vibration-exercise-on-neuromuscular-function-for-individuals-with-knee-osteoarthritis-study-protocol-for-a-randomized-controlled-trial
#3
Zhangqi Lai, Xueqiang Wang, Seullee Lee, Xihe Hou, Lin Wang
BACKGROUND: Knee osteoarthritis (KOA) is a leading cause of public disability. Neuromuscular function contributes to the development and/or progression of KOA. Whole body vibration (WBV) exercise improve the neuromuscular function of patients with neurological disorders and even that of older patients with limited exercise options. Therefore, WBV exercise may offer an efficient and alternative treatment for individuals with KOA. However, the effects of WBV training on the neuromuscular function of individuals with KOA remain unclear...
September 20, 2017: Trials
https://www.readbyqxmd.com/read/28931001/an-automated-rapid-iterative-negative-geotaxis-assay-for-analyzing-adult-climbing-behavior-in-a-drosophila-model-of-neurodegeneration
#4
Wenze Cao, Li Song, Jingjing Cheng, Na Yi, Luyi Cai, Fu-de Huang, Margaret Ho
Neurodegenerative diseases are frequently associated with a progressive loss of movement ability, reduced life span, and age-dependent neurodegeneration. To understand the mechanism of these cellular events, and their causal relationships with each other, Drosophila melanogaster, with its sophisticated genetic tools and diverse behavioral features, are used as disease models for assessing neurodegenerative phenotypes. Here we describe a high-throughput method to analyze Drosophila adult negative geotaxis behavior, as an indication for possible motor defects associated with neurodegeneration...
September 12, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28930453/ab-initio-qm-mm-modelling-of-the-rate-limiting-proton-transfer-step-in-the-deamination-of-tryptamine-by-aromatic-amine-dehydrogenase
#5
Kara Elizabeth Ranaghan, William G Morris, Laura Masgrau, Kittusamy Senthilkumar, Linus O Johannissen, Nigel S Scrutton, Jeremy N Harvey, Frederick R Manby, Adrian J Mulholland
Aromatic amine dehydrogenase (AADH) and related enzymes are at the heart of debates on the roles of quantum tunnelling and protein dynamics in catalysis. The reaction of tryptamine in AADH involves significant quantum tunnelling in the rate-limiting proton transfer step, shown e.g. by large H/D primary kinetic isotope effects (KIEs), with unusual temperature dependence. We apply correlated ab initio combined quantum mechanics/molecular mechanics (QM/MM) methods, at levels up to local coupled cluster theory (LCCSD(T)/(aug)-cc-pVTZ), to calculate accurate potential energy surfaces for this reaction, which are necessary for quantitative analysis of tunnelling contributions and reaction dynamics...
September 20, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28924815/automatic-determination-of-the-need-for-intravenous-contrast-in-musculoskeletal-mri-examinations-using-ibm-watson-s-natural-language-processing-algorithm
#6
Hari Trivedi, Joseph Mesterhazy, Benjamin Laguna, Thienkhai Vu, Jae Ho Sohn
Magnetic resonance imaging (MRI) protocoling can be time- and resource-intensive, and protocols can often be suboptimal dependent upon the expertise or preferences of the protocoling radiologist. Providing a best-practice recommendation for an MRI protocol has the potential to improve efficiency and decrease the likelihood of a suboptimal or erroneous study. The goal of this study was to develop and validate a machine learning-based natural language classifier that can automatically assign the use of intravenous contrast for musculoskeletal MRI protocols based upon the free-text clinical indication of the study, thereby improving efficiency of the protocoling radiologist and potentially decreasing errors...
September 18, 2017: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/28923581/constraints-representing-a-meta-stable-r%C3%A3-gime-facilitate-exploration-during-practice-and-transfer-of-learning-in-a-complex-multi-articular-task
#7
Dominic Orth, Keith Davids, Ludovic Seifert
Previous investigations have shown that inducing meta-stability in behavior can be achieved by overlapping affordances through constraint manipulation, allowing cooperative and competitive tendencies to functionally coexist. The purpose of this paper was to test a number of conditions applying these design principles on performance during skills practice and transfer. Of additional interest, was whether the existing skill level interacted with the environmental properties of the experimental tasks (varying indoor climbing routes)...
September 16, 2017: Human Movement Science
https://www.readbyqxmd.com/read/28915388/epa-and-dha-but-not-ala-have-antidepressant-effects-with-17%C3%AE-estradiol-injection-via-regulation-of-a-neurobiological-system-in-ovariectomized-rats
#8
Jeong-Eun Choi, Yongsoon Park
Our previous studies found that n-3 polyunsaturated fatty acids (PUFAs) and estrogen had synergistic antidepressant-like effects. The purpose of the present study was to investigate the hypothesis that three major n-3 PUFAs, α-linolenic acid (ALA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), individually had antidepressant effects combined with 17β-estradiol-3-benzoate (E) through a neurobiological pathway in ovariectomized rats. Rats were fed a modified American Institute of Nutrition-93G diet with 0% n-3 PUFAs and 1% ALA, EPA and DHA relative to total energy intake for 12 weeks and were injected with corn oil or E every 4 days during the last 3 weeks...
August 5, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28912435/turning-behaviors-of-t-cells-climbing-up-ramp-like-structures-are-regulated-by-myosin-light-chain-kinase-activity-and-lamellipodia-formation
#9
Kwang Hoon Song, Jaehyun Lee, Hong-Ryul Jung, HyoungJun Park, Junsang Doh
T cells navigate diverse microenvironments to perform immune responses. Micro-scale topographical structures within the tissues, which may inherently exist in normal tissues or may be formed by inflammation or injury, can influence T cell migration, but how T cell migration is affected by such topographical structures have not been investigated. In this study, we fabricated ramp-like structures with a 5 μm height and various slopes, and observed T cells climbing up the ramp-like structures. T cells encountering the ramp-like structures exhibited MLC accumulation near head-tail junctions contacting the ramp-like structures, and made turns to the direction perpendicular to the ramp-like structures...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28899903/socs3-expression-in-sf1-cells-regulates-adrenal-differentiation-and-exercise-performance
#10
João Ab Pedroso, Pedro Omori Ribeiro de Mendonça, Marco As Fortes, Igor Tomaz, Vitor L Pecorali, Thais B Auricino, Ismael C Costa, Leandro B Lima, Isadora C Furigo, Debora N Bueno, Angela M Ramos-Lobo, Claudimara Ferini Pacicco Lotfi, Jose Donato
Many hormones/cytokines are secreted in response to exercise and cytokine signaling may play a pivotal role in the training adaptations. To investigate the importance of cytokine signaling during vertical ladder climbing, a resistance exercise model, we produced mice lacking SOCS3 protein exclusively in steroidogenic factor-1 (SF1) cells (SF1 Socs3 KO mice). SF1 expression is found in steroidogenic cells of the adrenal cortex and gonads, as well as in neurons of the ventromedial nucleus of the hypothalamus...
September 12, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28898648/motor-control-crf-regulates-coordination-and-gait
#11
Mario Manto
The function of the olivo-cerebellar tract is not restricted to the supervision of plasticity in the cerebellar cortex. There is growing evidence that the climbing fibers also tune motor commands. A novel study unravels a role of corticotropin-releasing factor (CRF) in motor coordination and gait control.
September 11, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28898613/functional-sensorial-mobility-and-communication-difficulties-in-the-portuguese-oldest-old-80
#12
Daniela Brandão, Óscar Ribeiro, Constança Paúl
INTRODUCTION: The ageing of populations is evident in most developed countries, and the oldest old group is one of the segments with the fastest growing. The aim of this paper is to examine sociodemographic and health related characteristics of the portuguese oldest old, using a census-based approach. MATERIAL AND METHODS: A descriptive study considering all residents aged 80 years and older at the time of the 2011 Census (n = 532 219) was conducted. Information on sociodemographic characteristics, sensory functions (seeing, hearing), functional status (walking/climbing stairs, bathing/dressing alone), cognition (memory/concentration), and communication (understanding others/being understood) as assessed by the Portuguese census official questionnaires were analyzed...
June 30, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28895648/collateral-impact-a-dual-role-for-climbing-fibre-collaterals-to-the-cerebellar-nuclei
#13
Jasmine Pickford, Richard Apps
The principal source of synaptic inputs to the cerebellum arise from mossy fibres and climbing fibres (CFs). This article is protected by copyright. All rights reserved.
September 12, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28894610/maturation-refinement-and-serotonergic-modulation-of-cerebellar-cortical-circuits-in-normal-development-and-in-murine-models-of-autism
#14
REVIEW
Eriola Hoxha, Pellegrino Lippiello, Bibiana Scelfo, Filippo Tempia, Mirella Ghirardi, Maria Concetta Miniaci
The formation of the complex cerebellar cortical circuits follows different phases, with initial synaptogenesis and subsequent processes of refinement guided by a variety of mechanisms. The regularity of the cellular and synaptic organization of the cerebellar cortex allowed detailed studies of the structural plasticity mechanisms underlying the formation of new synapses and retraction of redundant ones. For the attainment of the monoinnervation of the Purkinje cell by a single climbing fiber, several signals are involved, including electrical activity, contact signals, homosynaptic and heterosynaptic interaction, calcium transients, postsynaptic receptors, and transduction pathways...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/28889022/injection-of-oxytocin-into-paraventricular-nucleus-reverses-depressive-like-behaviors-in-the-postpartum-depression-rat-model
#15
Tong Wang, Cuige Shi, Xiaoxiao Li, Pan Zhang, Bo Liu, Hao Wang, Yongjun Wang, Yutao Yang, Yan Wu, Hui Li, Zhi-Qing David Xu
Oxytocin (OXT) has been considered as a neuroregulator mediating social behaviors and stress-related disorders. Recent clinical studies suggest that OXT might also act as antidepressant in postpartum depression (PPD) patients, but the mechanism is still unknown. In the present study, we explored the effect of OXT in paraventricular nucleus (PVN) and possible signaling pathway involved in a PPD rat model induced by gestation restraint stress (GRS). PPD rats exhibited depressive-like behaviors with significantly longer immobility time, shorter climbing time, and lower sucrose consumption compared to the control rats...
September 6, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28888851/long-term-longitudinal-study-of-muscle-function-in-patients-with-glycogen-storage-disease-type-iiia
#16
Valérie Decostre, Pascal Laforêt, Marie De Antonio, Kahina Kachetel, Aurélie Canal, Gwenn Ollivier, Aleksandra Nadaj-Pakleza, François M Petit, Karim Wahbi, Abdallah Fayssoil, Bruno Eymard, Anthony Behin, Philippe Labrune, Jean-Yves Hogrel
Glycogen storage disease type III (GSDIII) is an autosomal recessive disorder caused by mutations in the AGL gene coding for the glycogen debranching enzyme. Current therapy is based on dietary adaptations but new preclinical therapies are emerging. The identification of outcome measures which are sensitive to disease progression becomes critical to assess the efficacy of new treatments in upcoming clinical trials. In order to prepare future longitudinal studies or therapeutic trials with large cohorts, information about disease progression is required...
August 30, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/28888448/effect-of-explosion-puffed-coffee-on-locomotor-activity-and-behavioral-patterns-in-drosophila-melanogaster
#17
Bong Soo Ko, So Hyun Ahn, Dong Ouk Noh, Ki-Bae Hong, Sung Hee Han, Hyung Joo Suh
We hypothesized that the administration of explosion-puffed coffee, containing γ-aminobutyric acid (GABA) and 5-hydroxytryptophan (5-HTP), would be associated with a reduction of the caffeine effect on sleep behavior and behavioral patterns, which was investigated in a Drosophila model. The effects of feeding roasted coffee beans (RB), explosion-puffed coffee beans puffed at 0.75MPa and 0.9MPa (PB 7.5 and PB 9.0, respectively), or decaffeinated coffee beans (DeRB) on locomotor activity and behavioral patterns of Drosophila was analyzed...
October 2017: Food Research International
https://www.readbyqxmd.com/read/28888193/children-s-perception-of-action-boundaries-and-how-it-affects-their-climbing-behavior
#18
James L Croft, Gert-Jan Pepping, Chris Button, Jia-Yi Chow
There are some concerns that children today may be less calibrated to their action capabilities because of the "risk-free" culture that has proliferated during recent decades. This study investigated the extent to which judgments of reaching affordances presented in different directions (i.e., overhead, diagonal, and horizontal) are related to children's climbing behavior on a climbing wall. A sample of 30 schoolchildren from 6 to 11years old (20 boys and 10 girls) estimated maximum reach and grasp distances and subsequently attempted to climb across an indoor climbing wall...
September 6, 2017: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/28885297/spinal-surgeons-opinions-on-pre-and-postoperative-rehabilitation-in-patients-undergoing-lumbar-spinal-fusion-surgery-a-survey-based-study-in-the-netherlands-and-sweden
#19
Reni M A van Erp, Jetse Jelsma, Ivan P J Huijnen, Mari Lundberg, Paul C Willems, Rob J E M Smeets
STUDY DESIGN: A cross-sectional survey in the Netherlands and Sweden. OBJECTIVE: To investigate Dutch and Swedish spinal surgeons' opinions on spinal fusion pre- and postoperative rehabilitation. SUMMARY OF BACKGROUND DATA: Lumbar spinal fusion surgery is increasingly provided in patients with chronic low back pain. No guidelines however exist for pre- and postoperative rehabilitation and it is unknown what opinions spinal surgeons currently have about pre- and postoperative rehabilitation...
September 6, 2017: Spine
https://www.readbyqxmd.com/read/28882263/evaluating-the-stability-of-a-freestanding-mast-climbing-work-platform
#20
Bryan Wimer, Christopher Pan, Tim Lutz, Mat Hause, Chris Warren, Ren Dong, Sherry Xu
Mast Climbing Work Platforms (MCWPs) are becoming more common at construction sites and are being used as an alternative to traditional scaffolding. Although their use is increasing, little to no published information exists on the potential safety hazards they could pose for workers. As a last line of defense, a personal fall-arrest system can be used to save a worker in a fall incident from the platform. There has been no published information on whether it is safe to use such a personal fall-arrest system with MCWPs...
September 2017: Journal of Safety Research
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