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https://www.readbyqxmd.com/read/28325033/user-intent-prediction-with-a-scaled-conjugate-gradient-trained-artificial-neural-network-for-lower-limb-amputees-using-a-powered-prosthesis
#1
Richard B Woodward, John A Spanias, Levi J Hargrove
Powered lower limb prostheses have the ability to provide greater mobility for amputee patients. Such prostheses often have pre-programmed modes which can allow activities such as climbing stairs and descending ramps, something which many amputees struggle with when using non-powered limbs. Previous literature has shown how pattern classification can allow seamless transitions between modes with a high accuracy and without any user interaction. Although accurate, training and testing each subject with their own dependent data is time consuming...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28324764/enhancing-mitofusin-marf-ameliorates-neuromuscular-dysfunction-in-drosophila-models-of-tdp-43-proteinopathies
#2
Bilal Khalil, Marie-Jeanne Cabirol-Pol, Laetitia Miguel, Alexander J Whitworth, Magalie Lecourtois, Jean-Charles Liévens
Transactive response DNA-binding protein 43 kDa (TDP-43) is considered a major pathological protein in amyotrophic lateral sclerosis and frontotemporal lobar degeneration. The precise mechanisms by which TDP-43 dysregulation leads to toxicity in neurons are not fully understood. Using TDP-43-expressing Drosophila, we examined whether mitochondrial dysfunction is a central determinant in TDP-43 pathogenesis. Expression of human wild-type TDP-43 in Drosophila neurons results in abnormally small mitochondria...
February 27, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28323761/effect-of-land-based-generic-physical-activity-interventions-on-pain-physical-function-and-physical-performance-in-hip-and-knee-osteoarthritis-a-systematic-review-and-meta-analysis
#3
Shanelle Fernandopulle, Meredith Perry, Donald Manlapaz, Prasath Jayakaran
OBJECTIVE: The aim of this study was to evaluate the effects of land-based generic physical activity interventions on pain, physical function, and physical performance in individuals with hip/knee osteoarthritis, when compared with a control group that received no intervention, minimal intervention, or usual care. METHODS: A systematic search for randomized controlled trials on 11 electronic databases (from their inception up until April 30, 2016) identified 27 relevant articles...
March 18, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28317555/the-cervical-spine-of-australopithecus-sediba
#4
Marc R Meyer, Scott A Williams, Peter Schmid, Steven E Churchill, Lee R Berger
Cervical vertebrae are rare in the early hominin fossil record, presenting a challenge for understanding the evolution of the neck and head carriage in hominin evolution. Here, we examine the cervical vertebrae of Australopithecus sediba, which unlike other South African taxa is known from associated cervical vertebrae. The A. sediba cervical vertebrae exhibit human-like values for wedging, pedicle cross-sectional areas, and articular facet heights, indicating reduced ventral loading relative to African apes...
March 2017: Journal of Human Evolution
https://www.readbyqxmd.com/read/28317552/adaptation-to-suspensory-locomotion-in-australopithecus-sediba
#5
Thomas R Rein, Terry Harrison, Kristian J Carlson, Katerina Harvati
Australopithecus sediba is represented by well-preserved fossilized remains from the locality of Malapa, South Africa. Recent work has shown that the combination of features in the limb skeleton of A. sediba was distinct from that of earlier species of Australopithecus, perhaps indicating that this species moved differently. The bones of the arm and forearm indicate that A. sediba was adapted to suspensory and climbing behaviors. We used a geometric morphometric approach to examine ulnar shape, potentially identifying adaptations to forelimb suspensory locomotion in A...
March 2017: Journal of Human Evolution
https://www.readbyqxmd.com/read/28306154/protein-intake-and-mobility-limitation-in-community-dwelling-older-adults-the-health-abc-study
#6
Denise K Houston, Janet A Tooze, Katelyn Garcia, Marjolein Visser, Susan Rubin, Tamara B Harris, Anne B Newman, Stephen B Kritchevsky
OBJECTIVES: The current Recommended Dietary Allowance (RDA) for protein is based on short-term nitrogen balance studies in young adults and may underestimate the amount needed to optimally preserve physical function in older adults. We examined the association between protein intake and the onset of mobility limitation over 6 years of follow-up in older adults in the Health ABC study. DESIGN: Prospective cohort study. SETTING: Memphis, Tennessee and Pittsburgh, Pennsylvania...
March 17, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28303944/relationships-between-strength-and-endurance-parameters-and-air-depletion-rates-in-professional-firefighters
#7
Stephanie Windisch, Wolfgang Seiberl, Ansgar Schwirtz, Daniel Hahn
The aim of this study was to quantify the physical demands of a simulated firefighting circuit and to establish the relationship between job performance and endurance and strength fitness measurements. On four separate days 41 professional firefighters (39 ± 9 yr, 179.6 ± 2.3 cm, 84.4 ± 9.2 kg, BMI 26.1 ± 2.8 kg/m(2)) performed treadmill testing, fitness testing (strength, balance and flexibility) and a simulated firefighting exercise. The firefighting exercise included ladder climbing (20 m), treadmill walking (200 m), pulling a wire rope hoist (15 times) and crawling an orientation section (50 m)...
March 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28302377/stair-negotiation-as-a-rehabilitation-intervention-for-enhancing-recovery-following-total-hip-and-knee-replacement-surgery
#8
REVIEW
James P Gavin, Tikki Immins, Thomas Wainwright
BACKGROUND: Total hip replacement (THR) and total knee replacement (TKR) are common orthopaedic procedures. However, an optimal programme for post-operative rehabilitation has yet to be established. Stair negotiation is a challenging, habitual task, regularly used as a post-operative functional outcome measure; yet as a physical rehabilitation intervention it appears to be rarely used. AIM: The review purpose was to investigate the effectiveness of stair climbing as a rehabilitation intervention for THR and TKR patients...
October 20, 2016: International Journal of Orthopaedic and Trauma Nursing
https://www.readbyqxmd.com/read/28301444/hemodynamic-and-cardiorespiratory-predictors-of-sport-rock-climbing-performance
#9
Simon Fryer, David Giles, Inmaculada Garrido Palomino, Alejandro de la O Puerta, Vanesa España Romero
Rock climbing performance has been suggested to involve a notable contribution from the aerobic metabolism. Previously it has been shown that forearm oxygenation kinetics can be used to distinguish ability groups and predict red-point sport climbing performance. Currently it is not known if forearm oxygenation kinetics, or a sport specific assessment of cardiorespiratory fitness best predicts sport rock climbing performance. The aim of the study was to determine whether forearm oxidative capacity index, maximal de-oxygenation (Δ score) during a treadwall V[Combining Dot Above]O[SUBSCRIPT TWO]peak test, treadwall V[Combining Dot Above]O[SUBSCRIPT TWO]peak, or running V[Combining Dot Above]O[SUBSCRIPT TWO]max best predicts self-reported sport climbing performance...
March 13, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28300156/superconductivity-in-hfte5-across-weak-to-strong-topological-insulator-transition-induced-via-pressures
#10
Y Liu, Y J Long, L X Zhao, S M Nie, S J Zhang, Y X Weng, M L Jin, W M Li, Q Q Liu, Y W Long, R C Yu, C Z Gu, F Sun, W G Yang, H K Mao, X L Feng, Q Li, W T Zheng, H M Weng, X Dai, Z Fang, G F Chen, C Q Jin
Recently, theoretical studies show that layered HfTe5 is at the boundary of weak &strong topological insulator (TI) and might crossover to a Dirac semimetal state by changing lattice parameters. The topological properties of 3D stacked HfTe5 are expected hence to be sensitive to pressures tuning. Here, we report pressure induced phase evolution in both electronic &crystal structures for HfTe5 with a culmination of pressure induced superconductivity. Our experiments indicated that the temperature for anomaly resistance peak (Tp) due to Lifshitz transition decreases first before climbs up to a maximum with pressure while the Tp minimum corresponds to the transition from a weak TI to strong TI...
March 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28297429/method-and-phantom-to-study-combined-effects-of-in-plane-x-y-and-z-axis-resolution-for-3d-ct-imaging
#11
David Goodenough, Josh Levy, Smari Kristinsson, Jesper Fredriksson, Hildur Olafsdottir, Austin Healy
Increasingly, the advent of multislice CT scanners, volume CT scanners, and total body spiral acquisition modes has led to the use of Multi Planar Reconstruction and 3D datasets. In considering 3D resolution properties of a CT system it is important to note that both the in-plane (x,y) and z-axis (slice thickness) influence the visualization and detection of objects within the scanned volume. This study investigates ways to consider both the in-plane resolution and the z-axis resolution in a single phantom wherein analytic or visualized analysis can yield information on these combined effects...
September 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28296942/co-ingestion-of-carbohydrate-and-whey-protein-increases-fasted-rates-of-muscle-protein-synthesis-immediately-after-resistance-exercise-in-rats
#12
Wanyi Wang, Zhenping Ding, Geoffrey J Solares, Soon-Mi Choi, Bo Wang, Aram Yoon, Roger P Farrar, John L Ivy
The objective of the study was to investigate whether co-ingestion of carbohydrate and protein as compared with protein alone augments muscle protein synthesis (MPS) during early exercise recovery. Two months old rats performed 10 repetitions of ladder climbing with 75% of body weight attached to their tails. Placebo (PLA), whey protein (WP), or whey protein plus carbohydrate (CP) was then given to rats by gavage. An additional group of sedentary rats (SED) was used as controls. Blood samples were collected immediately and at either 1 or 2 h after exercise...
2017: PloS One
https://www.readbyqxmd.com/read/28293172/ethanol-modulates-the-spontaneous-complex-spike-waveform-of-cerebellar-purkinje-cells-recorded-in-vivo-in-mice
#13
Guang-Jian Zhang, Mao-Cheng Wu, Jin-Di Shi, Yin-Hua Xu, Chun-Ping Chu, Song-Biao Cui, De-Lai Qiu
Cerebellar Purkinje cells (PCs) are sensitive to ethanol, but the effect of ethanol on spontaneous complex spike (CS) activity in these cells in vivo is currently unknown. Here, we investigated the effect of ethanol on spontaneous CS activity in PCs in urethane-anesthetized mice using in vivo patch-clamp recordings and pharmacological manipulation. Ethanol (300 mM) induced a decrease in the CS-evoked pause in simple spike (SS) firing and in the amplitude of the afterhyperpolarization (AHP) under current clamp conditions...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28289890/kinematic-analysis-of-stair-climbing-in-rotating-platform-cruciate-retaining-and-posterior-stabilized-mobile-bearing-total-knee-arthroplasties
#14
Koji Murakami, Satoshi Hamai, Ken Okazaki, Satoru Ikebe, Hiroyuki Nakahara, Hidehiko Higaki, Takeshi Shimoto, Hideki Mizu-Uchi, Umito Kuwashima, Yukihide Iwamoto
INTRODUCTION: The aim of our study was to compare and contrast the effects of two types of mobile-bearing total knee arthroplasties (TKA), namely, the cruciate-retaining (CR) and posterior-stabilized (PS) TKAs, on clinical outcomes and in vivo kinematics during stair climbing. MATERIALS AND METHODS: The Press-Fit Condylar Sigma rotating platform was used for both CR and PS TKAs. Patient-reported outcomes were assessed using the 2011 Knee Society Score. Quadriceps muscle strength was evaluated by isokinetic dynamometry...
March 13, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28288826/evaluation-of-acute-and-subacute-toxicity-of-hydroethanolic-extract-of-dolichandra-unguis-cati-l-leaves-in-rats
#15
Juliana Calil Brondani, Fernanda Ziegler Reginato, Evelyne da Silva Brum, Marina de Souza Vencato, Cibele Lima Lhamas, Carine Viana Silva, Maria Izabel Ugalde Marques da Rocha, Liliane de Freitas Bauermann, Melânia Palermo Manfron
ETHNOPHARMACOLOGICAL RELEVANCE: Dolichandra unguis-cati L. is a native climbing plant of Brazil, popularly known as "unha de gato". It has been traditionally used mainly as an antipyretic, anti-inflammatory and anti-tumor agent, yet little toxicological information is found in the literature. AIM OF THE STUDY: To identify the chemical composition of the hydroethanolic extract obtained from the leaves of Dolichandra uniguis-cati and to evaluate the acute and subacute toxicity in male and female rats, in order to assess the safety profile of this plant...
March 10, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28287821/a-particle-swarm-optimization-based-approach-with-local-search-for-predicting-protein-folding
#16
Cheng-Hong Yang, Yu-Shiun Lin, Li-Yeh Chuang, Hsueh-Wei Chang
The hydrophobic-polar (HP) model is commonly used for predicting protein folding structures and hydrophobic interactions. This study developed a particle swarm optimization (PSO)-based algorithm combined with local search algorithms; specifically, the high exploration PSO (HEPSO) algorithm (which can execute global search processes) was combined with three local search algorithms (hill-climbing algorithm, greedy algorithm, and Tabu table), yielding the proposed HE-L-PSO algorithm. By using 20 known protein structures, we evaluated the performance of the HE-L-PSO algorithm in predicting protein folding in the HP model...
March 13, 2017: Journal of Computational Biology: a Journal of Computational Molecular Cell Biology
https://www.readbyqxmd.com/read/28286525/mesenchymal-stem-and-progenitor-cells-in-regeneration-tissue-specificity-and-regenerative-potential
#17
REVIEW
Rokhsareh Rohban, Thomas Rudolf Pieber
It has always been an ambitious goal in medicine to repair or replace morbid tissues for regaining the organ functionality. This challenge has recently gained momentum through considerable progress in understanding the biological concept of the regenerative potential of stem cells. Routine therapeutic procedures are about to shift towards the use of biological and molecular armamentarium. The potential use of embryonic stem cells and invention of induced pluripotent stem cells raised hope for clinical regenerative purposes; however, the use of these interventions for regenerative therapy showed its dark side, as many health concerns and ethical issues arose in terms of using these cells in clinical applications...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28286087/minos-insertion-mutant-of-the-drosophila-gba-gene-homologue-showed-abnormal-phenotypes-of-climbing-ability-sleep-and-life-span-with-accumulation-of-hydroxy-glucocerebroside
#18
Haruhisa Kawasaki, Takahiro Suzuki, Kumpei Ito, Tsubasa Takahara, Naoko Goto-Inoue, Mitsutoshi Setou, Kazuki Sakata, Norio Ishida
Gaucher's disease in humans is considered a deficiency of glucocerebrosidase (GlcCerase) that result in the accumulation of its substrate, glucocerebroside (GlcCer). Although mouse models of Gaucher's disease have been reported from several laboratories, these models are limited due to the perinatal lethality of GlcCerase gene. Here, we examined phenotypes of Drosophila melanogaster homologues genes of the human Gaucher's disease gene by using Minos insertion. One of two Minos insertion mutants to unknown function gene (CG31414) accumulates the hydroxy-GlcCer in whole body of Drosophila melanogaster...
March 7, 2017: Gene
https://www.readbyqxmd.com/read/28286041/combined-submuscular-tissue-expansion-and-anterior-component-separation-technique-for-abdominal-wall-reconstruction-long-term-outcome-analysis
#19
Brendan Alleyne, Cemile Nurdan Ozturk, Antonio Rampazzo, Jeffrey Johnson, Raffi Gurunluoglu
BACKGROUND: We report the long-term outcome analysis of 12 patients who underwent two-stage abdominal wall reconstruction using combined submuscular tissue expansion and anterior components separation (CS) technique. METHODS: Outcome measures were (1) the patients were assessed for the presence or absence of recurrence; (2) patient-reported outcomes on physical functioning in relation with the abdominal wall reconstruction were evaluated using the SF 36-item health survey...
February 17, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28285897/arthrofibrosis-associated-with-total-knee-arthroplasty
#20
REVIEW
Victor A Cheuy, Jared R H Foran, Roger J Paxton, Michael J Bade, Joseph A Zeni, Jennifer E Stevens-Lapsley
The purpose of this article is to review the etiology, economic burden, treatment strategies, and future research directions of arthrofibrosis after total knee arthroplasty (TKA). Arthrofibrosis is a debilitating postoperative complication of TKA. This condition is one of the leading causes of hospital readmission and a predominant reason for TKA failure. The prevalence of arthrofibrosis will increase as the annual incidence of TKA in the United States rises into the millions. Characterized by the excessive proliferation of scar tissue during an impaired wound healing response, the resulting stiffness of arthrofibrosis causes functional deficits in activities of daily living, such as walking, stair climbing, and standing from a chair...
February 14, 2017: Journal of Arthroplasty
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