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https://www.readbyqxmd.com/read/28644933/survey-of-hand-and-upper-extremity-injuries-among-rock-climbers
#1
Clayton E Nelson, Ghazi M Rayan, Dustin I Judd, Kai Ding, Julie A Stoner
BACKGROUND: Rock climbing first evolved as a sport in the late 18th century. With its growing popularity, the number of rock climbing-related injuries has potential to increase, spurring a rise in the number of articles associated with it. Despite the available literature, there remains a paucity of information about upper extremity injuries sustained by rock climbers, and no studies to date have focused on gender-specific injuries. METHODS: A 24-question online survey was distributed to rock climbers about upper extremity injuries sustained during rock climbing...
July 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28642483/masking-of-a-circadian-behavior-in-larval-zebrafish-involves-the-thalamo-habenula-pathway
#2
Qian Lin, Suresh Jesuthasan
Changes in illumination can rapidly influence behavior that is normally controlled by the circadian clock. This effect is termed masking. In mice, masking requires melanopsin-expressing retinal ganglion cells that detect blue light and project to the thalamus. It is not known whether masking is wavelength-dependent in other vertebrates, nor is it known whether the thalamus is also involved or how it influences masking. Here, we address these questions in zebrafish. We find that diel vertical migration, a circadian behavior in larval zebrafish, is effectively triggered by blue, but not by red light...
June 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28637914/soiled-adhesive-pads-shear-clean-by-slipping-a-robust-self-cleaning-mechanism-in-climbing-beetles
#3
Guillermo J Amador, Thomas Endlein, Metin Sitti
Animals using adhesive pads to climb smooth surfaces face the problem of keeping their pads clean and functional. Here, a self-cleaning mechanism is proposed whereby soiled feet would slip on the surface due to a lack of adhesion but shed particles in return. Our study offers an in situ quantification of self-cleaning performance in fibrillar adhesives, using the dock beetle as a model organism. After beetles soiled their pads by stepping into patches of spherical beads, we found that their gait was significantly affected...
June 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/28637772/tolerance-to-increased-supplemented-dietary-intakes-of-methionine-in-healthy-older-adults
#4
Nicolaas Ep Deutz, Sunday Y Simbo, Gerdien C Ligthart-Melis, Luc Cynober, Miro Smriga, Mariëlle Pkj Engelen
Background: l-Methionine (Met) is an essential amino acid for humans and is important for protein synthesis and the formation of polyamines and is involved in the synthesis of many metabolites, including homocysteine. Free-Met supplements have been claimed to have multiple positive effects; however, it remains unclear what the exact tolerance level is. With aging, Met metabolism changes, and increased plasma homocysteine is more apparent. High plasma concentrations of homocysteine are assumed to be associated with a high risk of developing atherosclerosis...
June 21, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28637145/amount-of-balance-necessary-for-the-independence-of-transfer-and-stair-climbing-in-stroke-inpatients
#5
Takaaki Fujita, Atsushi Sato, Yuji Ohashi, Kazutaka Nishiyama, Takuro Ohashi, Kazuhiro Yamane, Yuichi Yamamoto, Kenji Tsuchiya, Koji Otsuki, Fusae Tozato
PURPOSE: The purpose of this study was to clarify the amount of balance necessary for the independence of transfer and stair-climbing in stroke patients. METHOD: This study included 111 stroke inpatients. Simple and multiple regression analyses were conducted to establish the association between the FIM(®) instrument scores for transfer or stair-climbing and Berg Balance Scale. Furthermore, receiver operating characteristic curves were used to elucidate the amount of balance necessary for the independence of transfer and stair-climbing...
February 23, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28634887/aberrant-connections-between-climbing-fibres-and-purkinje-cells-induce-alterations-in-the-timing-of-an-instrumental-response-in-the-rat
#6
Lorena Gaytán-Tocavén, Miguel Ángel López-Vázquez, Miguel Ángel Guevara, María Esther Olvera-Cortés
Cerebellar participation in timing and sensory-motor sequences has been supported by several experimental and clinical studies. A relevant role of the cerebellum in timing of conditioned responses in the range of milliseconds has been demonstrated, but less is known regarding the role of the cerebellum in supra-second timing of operant responses. A dissociated role of the cerebellum and striatum in timing in the millisecond and second range had been reported, respectively. The climbing fibre-Purkinje cell synapse is crucial in timing models; thus, the aberrant connection between these cellular elements is a suitable model for evaluating the contribution of the cerebellum in timing in the supra-second range...
June 20, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28633973/patellofemoral-osteoarthritis-progression-and-alignment-changes-after-open-wedge-high-tibial-osteotomy-do-not-affect-clinical-outcomes-at-mid-term-follow-up
#7
Kenichi Goshima, Takeshi Sawaguchi, Kenji Shigemoto, Shintaro Iwai, Akira Nakanishi, Ken Ueoka
PURPOSE: To evaluate the clinical and radiological outcomes of open-wedge high tibial osteotomy (OWHTO) with respect to the patellofemoral joint and to assess whether patellofemoral osteoarthritis (OA) progression and alignment changes after OWHTO affect clinical outcomes. METHODS: Inclusion criteria were consecutive patients who underwent OWHTO from March 2005 to September 2013. Exclusion criteria were loss to follow-up within 2 years and absence of second-look arthroscopy findings at the time of plate removal...
June 17, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28633950/a-multi-scale-integrated-modeling-framework-to-measure-comprehensive-impact-of-coastal-reclamation-activities-in-yellow-river-estuary-china
#8
Yan Xu, Yanpeng Cai, Tao Sun, Qian Tan
In this paper, an improved multi-scale integrated modeling framework has been established to evaluate coastal reclamation intensity (CRI). About 7 indicators are considered, including ecological degradation intensity (EDI), hydrodynamic disturbance (IHD), engineering types, water quality, economic investment, population growth, and reclaimed land area. Meanwhile, an integrated framework enhanced methods in terms of (a) measuring intensity of ecological degradation process under multi-scale impact, (b) developing the indicator system of CRI, and discussing the driving forces and trends of coastal reclamation, (c) determining fuzzy preference relations of weight and calculating the specific value of CRI with the case study areas of Yellow River estuary from 2000 to 2015...
June 17, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28627408/developmental-exposure-to-glyphosate-based-herbicide-and-depressive-like-behavior-in-adult-offspring-implication-of-glutamate-excitotoxicity-and-oxidative-stress
#9
Daiane Cattani, Patrícia Acordi Cesconetto, Mauren Kruger Tavares, Eduardo Benedetti Parisotto, Paulo Alexandre De Oliveira, Carla Elise Heinz Rieg, Marina Concli Leite, Rui Daniel Schröder Prediger, Nestor Cubas Wendt, Guilherme Razzera, Danilo Wilhelm Filho, Ariane Zamoner
We have previously demonstrated that maternal exposure to glyphosate-based herbicide (GBH) leads to glutamate excitotoxicity in 15-day-old rat hippocampus. The present study was conducted in order to investigate the effects of subchronic exposure to GBH on some neurochemical and behavioral parameters in immature and adult offspring. Rats were exposed to 1% GBH in drinking water (corresponding to 0.36% of glyphosate) from gestational day 5 until postnatal day (PND)-15 or PND60. Results showed that GBH exposure during both prenatal and postnatal periods causes oxidative stress, affects cholinergic and glutamatergic neurotransmission in offspring hippocampus from immature and adult rats...
June 13, 2017: Toxicology
https://www.readbyqxmd.com/read/28627377/mikania-glomerata-sprengel-extract-and-its-major-compound-ent-kaurenoic-acid-display-activity-against-bacteria-present-in-endodontic-infections
#10
Dora Lúcia Carrara Moreti, Luís Fernando Leandro, Thaís da Silva Moraes, Monique Rodrigues Moreira, Rodrigo Cassio Sola Veneziani, Sergio Ricardo Ambrosio, Brenda Paula Figueiredo Almeida Gomes, Carlos Henrique Gomes Martins
The search for new, effective and safe antimicrobial compounds from plant sources has continued to play an important role in the maintenance of human health since ancient times. Such compounds can be used to help to eradicate microorganisms from the root canal system, preventing/healing periapical diseases. Mikania glomerata (Spreng.), commonly known as "guaco," is a native climbing plant from Brazil that displays a wide range of pharmacological properties. Many of its activities have been attributed to its phytochemical composition, which is mainly composed of diterpenes, such as ent-kaurenoic acid (KA)...
June 13, 2017: Anaerobe
https://www.readbyqxmd.com/read/28620013/the-evolution-of-vertical-climbing-in-primates-evidence-from-reaction-forces
#11
Jandy B Hanna, Michael C Granatosky, Pooja Rana, Daniel Schmitt
Vertical climbing is an essential behavior for arboreal animals, yet limb mechanics during climbing are poorly understood and rarely compared to those observed during horizontal walking. Primates commonly engage in both arboreal walking and vertical climbing, and this makes them an ideal taxa in which to compare these locomotor forms. Additionally, primates exhibit unusual limb mechanics compared to most other quadrupeds, with weight distribution biased towards the hindlimbs, a pattern that is argued to have evolved in response to the challenges of arboreal walking...
June 15, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28619470/whole-body-hyperthermia-and-a-subthreshold-dose-of-citalopram-act-synergistically-to-induce-antidepressant-like-behavioral-responses-in-adolescent-rats
#12
Matthew W Hale, Jodi L Lukkes, Kathleen F Dady, Kyle J Kelly, Evan D Paul, David G Smith, Charles L Raison, Christopher A Lowry
BACKGROUND: Open and randomized, double blind, placebo-controlled clinical trials have demonstrated clinical efficacy of infrared whole-body hyperthermia in treatment of major depressive disorder (MDD). Demonstration of antidepressant-like behavioral effects of whole-body hyperthermia in preclinical rodent models would provide further support for the clinical use of infrared whole-body hyperthermia for the treatment of MDD, and would provide additional opportunities to explore underlying mechanisms...
June 12, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28619011/to-be-active-through-indoor-climbing-an-exploratory-feasibility-study-in-a-group-of-children-with-cerebral-palsy-and-typically-developing-children
#13
Mark Schram Christensen, Thor Jensen, Camilla B Voigt, Jens Bo Nielsen, Jakob Lorentzen
BACKGROUND: Cerebral Palsy (CP) is the most common cause of motor disabilities in children and young adults and it is also often associated with cognitive and physiological challenges. Climbing requires a multifaceted repertoire of movements, participants at all levels of expertise may be challenged functionally and cognitively, making climbing of great potential interest in (re)habilitation settings. However, until now only few research projects have investigated the feasibility of climbing as a potential activity for heightening physical activity in children with CP and the possible beneficial effects of climbing activities in populations with functional and/or cognitive challenges...
June 15, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28618641/kinetic-simulations-of-ladder-climbing-by-electron-plasma-waves
#14
Kentaro Hara, Ido Barth, Erez Kaminski, I Y Dodin, N J Fisch
The energy of plasma waves can be moved up and down the spectrum using chirped modulations of plasma parameters, which can be driven by external fields. Depending on whether the wave spectrum is discrete (bounded plasma) or continuous (boundless plasma), this phenomenon is called ladder climbing (LC) or autoresonant acceleration of plasmons. It was first proposed by Barth et al. [Phys. Rev. Lett. 115, 075001 (2015)PRLTAO0031-900710.1103/PhysRevLett.115.075001] based on a linear fluid model. In this paper, LC of electron plasma waves is investigated using fully nonlinear Vlasov-Poisson simulations of collisionless bounded plasma...
May 2017: Physical Review. E
https://www.readbyqxmd.com/read/28618000/in-vivo-analysis-of-synaptic-activity-in-cerebellar-nuclei-neurons-unravels-the-efficacy-of-excitatory-inputs
#15
Yasmin Yarden-Rabinowitz, Yosef Yarom
It is commonly agreed that the main function of the cerebellar system is to provide well-timed signals used for the execution of motor commands or prediction of sensory inputs. This function is manifested as a temporal sequence of spiking that should be expressed in the cerebellar nuclei projection neurons (CN). Whether spiking activity is generated by excitation or release from inhibition is still a hotly debated issue. In an attempt to resolve this debate, we recorded intracellularly from CN neurons in anaesthetized mice and performed an analysis of synaptic activity that yielded a number of important observations...
June 15, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28610519/nurse-vacancies-climb-to-all-time-high-in-scotland
#16
Matthew Mckew
Nursing and midwifery vacancies in Scotland continue to rise, as does spend on temporary staff, according to data released by the Information Services Division Scotland (ISD).
June 14, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28609838/hepatoprotective-mechanism-of-lygodium-microphyllum-cav-r-br-through-ultrastructural-signaling-prevention-against-carbon-tetrachloride-ccl4-mediated-oxidative-stress
#17
Charles Gnanaraj, Muhammad Dawood Shah, Tan Tek Song, Mohammad Iqbal
Plants have been consumed in medicinal practices for centuries. Lygodium microphyllum (Cav.) R.Br. (Lygodiaceae), also known as Old World Climbing Fern, is a medicinal plant used by local communities in Sabah for skin and dysentery ailments. This study aims to test aqueous extract of L. microphyllum leaves for hepatoprotective and immunosuppressive activity in rats. Animal studies were carried out to evaluate hepatoprotection of aqueous extract of L. microphyllum at different doses (200, 400 and 600mg/kg b...
June 9, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28606740/chronic-treatment-with-estradiol-restores-depressive-like-behaviors-in-female-wistar-rats-treated-neonatally-with-clomipramine
#18
Tania Molina Jiménez, Liliana Cadena Landa, Herlinda Bonilla Jaime
Neonatal administration of clomipramine (CMI) induces diverse behavioral and neurochemical alterations in adult male rats that resemble major depression disorder. However, the possible behavioral alterations in adult female rats subjected to neonatal treatment with clomipramine are unknown. Therefore, the aim of this study was to explore the effect of neonatal treatment with CMI on adult female rats in relation to locomotion and behavioral despair during the estrus cycle. Also evaluated was the effect of chronic treatment with E2 on these female CMI rats...
June 9, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28606139/a-loss-of-pdxk-model-of-parkinson-disease-in-drosophila-can-be-suppressed-by-buffy
#19
P Githure M'Angale, Brian E Staveley
BACKGROUND: The identification of a DNA variant in pyridoxal kinase (Pdxk) associated with increased risk to Parkinson disease (PD) gene led us to study the inhibition of this gene in the Dopa decarboxylase (Ddc)-expressing neurons of the well-studied model organism Drosophila melanogaster. The multitude of biological functions attributable to the vitamers catalysed by this kinase reveal an overabundance of possible links to PD, that include dopamine synthesis, antioxidant activity and mitochondrial function...
June 12, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28604379/physiotherapy-immediately-after-thymectomy-in-patients-with-myasthenia-gravis-two-cases-and-review-of-the-literature
#20
Massimiliano Polastri, Franco Stella, Massimo Lambertini, Walter Trani, Annalisa Ghetti, Andrea Dell'Amore
AIM: Myasthenia gravis (MG) is a rare autoimmune disease characterized by activation of autoantibodies against acetylcholine receptors: patients with MG typically experience muscle weakness and fatigue. The aims of the present study were 1) to describe immediate postoperative physiotherapeutic interventions in two MG patients who underwent thymectomy, and 2) to discuss postoperative rehabilitative issues in MG patients. MATERIALS AND METHODS: This was a non-experimental study analyzing two subjects with MG who underwent thymectomy...
2017: Annali Italiani di Chirurgia
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