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jose gomez-arroyo

Jose Gomez-Arroyo, Antonio Abbate, Norbert F Voelkel
No abstract text is available yet for this article.
August 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Silvia González Sanchidrián, Pedro Jesús Labrador Gómez, Jesús Pedro Marín Álvarez, María Carmen Jiménez Herrero, Inés Castellano Cerviño, Sandra Gallego Domínguez, José María Sánchez-Montalbán, Javier Deira Lorenzo, Elena Davin Carrero, Santiago Polanco Candelario, Juan Ramón Gómez-Martino Arroyo
No abstract text is available yet for this article.
July 16, 2016: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
Rafael Valencia-Quintana, Sandra Gómez-Arroyo, Juana Sánchez-Alarcón, Mirta Milić, José Luis Gómez Olivares, Stefan M Waliszewski, Josefina Cortés-Eslava, Rafael Villalobos-Pietrini, María Elena Calderón-Segura
This study evaluated direct and metabolic genotoxic effects caused by Lannate-90®, a methomyl-based formulation (90 % active ingredient), in human lymphocyte cultures using sister chromatid exchange assay (SCE). Two processes were used for the plant promutagens evaluation: in vivo activation, applying the insecticide systemically in plants for 4 h and subsequently adding plant metabolites containing extracts to lymphocyte cultures; and in vitro activation, where the insecticide was incubated with Vicia faba S10 mix plus human lymphocyte culture...
June 1, 2016: Arhiv za Higijenu Rada i Toksikologiju
José D Ordóñez-Gómez, Jurgi Cristóbal-Azkarate, Víctor Arroyo-Rodríguez, Ana M Santillán-Doherty, Ricardo A Valdez, Marta C Romano
The rapid loss, fragmentation and degradation of tropical forests threaten the survival of many animal species. However, the way in which these phenomena affect animal health has been poorly explored, thus limiting the design of appropriate conservation strategies. To address this, here we identified using linear mixed models the effect of proximal (diet, activity pattern, hunting and logging) and distal (sum of the basal areas of fruiting-tree species [SBAFS], landscape forest cover and degree of forest fragmentation) variables over fecal glucocorticoid metabolite (fGCM) levels-hormones associated with animal health and fitness-of six groups of spider monkeys (Ateles geoffroyi) inhabiting six landscapes with different spatial structures in Mexico...
2016: PloS One
Aleix Sala-Vila, Marta Guasch-Ferré, Frank B Hu, Ana Sánchez-Tainta, Mònica Bulló, Mercè Serra-Mir, Carmen López-Sabater, Jose V Sorlí, Fernando Arós, Miquel Fiol, Miguel A Muñoz, Luis Serra-Majem, J Alfredo Martínez, Dolores Corella, Montserrat Fitó, Jordi Salas-Salvadó, Miguel A Martínez-González, Ramón Estruch, Emilio Ros, B
BACKGROUND: Epidemiological evidence suggests a cardioprotective role of α-linolenic acid (ALA), a plant-derived ω-3 fatty acid. It is unclear whether ALA is beneficial in a background of high marine ω-3 fatty acids (long-chain n-3 polyunsaturated fatty acids) intake. In persons at high cardiovascular risk from Spain, a country in which fish consumption is customarily high, we investigated whether meeting the International Society for the Study of Fatty Acids and Lipids recommendation for dietary ALA (0...
January 2016: Journal of the American Heart Association
Lorena Rojas-Vega, Aldo R Jiménez-Vega, Silvana Bazúa-Valenti, Isidora Arroyo-Garza, José Victor Jiménez, Ruy Gómez-Ocádiz, Diego Luis Carrillo-Pérez, Erika Moreno, Luis E Morales-Buenrostro, Josefina Alberú, Gerardo Gamba
Evidence in rodents suggests that tacrolimus-induced posttransplant hypertension is due to upregulation of the thiazide-sensitive Na+-Cl- cotransporter NCC. Here, we analyzed whether a similar mechanism is involved in posttransplant hypertension in humans. From January 2013 to June 2014, all adult kidney transplant recipients receiving a kidney allograft were enrolled in a prospective cohort study. All patients received tacrolimus as part of the immunosuppressive therapy. Six months after surgery, we assessed general clinical and laboratory variables, tacrolimus trough blood levels, and ambulatory 24-h blood pressure monitoring...
November 15, 2015: American Journal of Physiology. Renal Physiology
Mariana Hernández-Gómez, Eva Ramirez-Arroyo, Ricardo Meléndez-Hernández, Luz Maria Garduño-Zaraza, Dora Gilda Mayén-Molina
BACKGROUND: Discovery of cell-free fetal DNA (cffDNA) in maternal blood in 1997 by Lo et al. has opened the possibility of a noninvasive prenatal test (NIPT). Currently, it is employed in the analysis of aneuploidies and fetal sex determination. Massive parallel sequencing (MPS) detects the origin of each amplified sequence, and analyses over-representation of sequences or any decrease in the fetal chromosomes in maternal plasma. This technique has been validated and allows assessment of trisomies 13, 18 and 21, obtaining the result in about a week from 10-weeks of gestational age...
May 2015: Ginecología y Obstetricia de México
María F Lorenzo-Gómez, Bárbara Padilla-Fernández, María B García-Cenador, Álvaro J Virseda-Rodríguez, Isidoro Martín-García, Alfonso Sánchez-Escudero, Manuel J Vicente-Arroyo, José A Mirón-Canelo
OBJECTIVE: To compare the clinical impact of a prophylactic treatment with sublingual immunostimulation in the prevention of recurrent urinary tract infections (rUTIs) with the use of antibiotics. MATERIAL AND METHODS: Retrospective cohort study evaluating the medical records of 669 women with rUTIs; 339 had a 6-month prophylaxis with antibiotics and 360 a 3-month prophylaxis with a sublingual bacterial preparation (MV 140-Uromune®). The time frame after the prophylaxis-period until the appearance of a new infection (assessed by uroculture) was scored and followed during 1 year...
2015: Frontiers in Cellular and Infection Microbiology
Norbert F Voelkel, Harm Jan Bogaard, Jose Gomez-Arroyo
For many patients with severe pulmonary arterial hypertension, heart failure-and, in particular, right heart failure-is the final chapter of their chronic illness. Targeted therapy for pulmonary hypertension is effective only if the right ventricular ejection fraction is maintained or improved. Because improvement of right heart function and reversal of right heart failure are treatment goals, it is important to investigate the cellular and molecular mechanisms that cause right heart failure. Here, we propose that right ventricular capillary rarefaction is an important hallmark of right heart failure and consider that the "sick lung circulation" and the pressure-overloaded right ventricle constitute a functional unit...
March 2015: Pulmonary Circulation
Lourdes Betancourt-Mendiola, Ismael Valois-Escamilla, Teresa Arbeloa, Jorge Bañuelos, Iñigo López Arbeloa, Juan O Flores-Rizo, Rongrong Hu, Erik Lager, César F A Gómez-Durán, José L Belmonte-Vázquez, Mayra R Martínez-González, Ismael J Arroyo, Carlos A Osorio-Martínez, Enrique Alvarado-Martínez, Arlette Urías-Benavides, Brenda D Gutiérrez-Ramos, Ben Zhong Tang, Eduardo Peña-Cabrera
Several new examples of meso-(het)arylBODIPY were prepared via the Liebeskind-Srogl (L-S) cross-coupling reaction of the Biellmann BODIPYs (1a,b) and aryl- and heteroarylboronic acids in good to excellent yield. It was shown that this reaction could be carried out under microwave heating to shorten reaction times and/or increase the yield. It was illustrated that organostannanes also participate in the L-S reaction to give the corresponding BODIPY analogues in short reaction times and also with good to excellent yields...
June 5, 2015: Journal of Organic Chemistry
Ignacio Arroyo-Carrera, María Solo de Zaldívar Tristancho, Eva Bermejo-Sánchez, María Luisa Martínez-Fernández, Amparo López-Lafuente, Alexandra MacDonald, Ángel Zúñiga, José Luis Gómez-Skarmeta, María Luisa Martínez-Frías
Warburg-Micro syndrome (WARBM) is an autosomal recessive syndrome characterized by microcephaly, microphthalmia, microcornea, congenital cataracts, optic atrophy and central nervous system malformations. This syndrome is caused by mutations in the RAB3GAP1/2 and RAB18 genes, part of the Rab family, and in the TBC1D20 gene, which contributes to lipid droplet formation/metabolism. Here we present a patient with clinical diagnosis of WARBM syndrome, who did not have mutations in either the RAB3GAP1/2 genes, in the main exons of RAB18, nor in the TBC1D20 gene...
June 2015: American Journal of Medical Genetics. Part A
Julio Sandoval, Jose Gomez-Arroyo, Jorge Gaspar, Tomas Pulido-Zamudio
Despite significant advances in pharmacological treatments, pulmonary arterial hypertension remains an incurable disease with an unreasonably high morbidity and mortality. Although specific pharmacotherapies have shifted the survival curves of patients and improved exercise endurance as well as quality of life, it is also true that these pharmacological interventions are not always accessible (particularly in developing countries) and, perhaps most importantly, not all patients respond similarly to these drugs...
October 2015: Journal of Cardiology
José Luis Martínez-Arroyo, Alejandro Gómez-García, Demetrio Sauceda-Martínez
INTRODUCTION: Many older adults have multiple medical conditions that require medical attention, exposing them to polypharmacy and to a higher increase in prescribing potentially inappropriate medications. These situations may cause adverse drug reactions, longer hospital stays, and death. The prevalence of polypharmacy in our country is estimated at 55% and inappropriate prescribing of medications of 30%. OBJECTIVE: To determine the prevalence of polypharmacy and potentially inappropriate drug prescription in older patients hospitalized for cardiovascular diseases...
December 2014: Gaceta Médica de México
María Jesús Pérez Elías, David Arroyo, Alberto Diaz, Cristina Herrero, Loreto Martinez-Dueñas, Ana Moreno, Jose Hernández-Quero, Daniel Podzamcer, Cristina Gomez-Ayerbe, Jose Luis Casado, Javier Zamora, Antonio Rivero, Santiago Moreno, Josep María Llibre
INTRODUCTION: No controlled clinical trials had studied the role of maraviroc (MRV) in fully suppressed patients (1). MATERIALS AND METHODS: MRV-cohort is an observational, retrospective, multicentric (27 sites) large cohort study of patients starting MRV in clinical practice under different circumstances, with at least 48 weeks of follow-up. For the present analysis we selected all those patients starting with an HIV-RNA<50 copies/mL. Demographics, baseline CD4 cell count, past history of antiretroviral treatment (ART), tropism, reasons for MRV use, MRV based therapy and change/end of MRV use were assessed...
2014: Journal of the International AIDS Society
Jose Gomez-Arroyo, Masahiro Sakagami, Aamer A Syed, Laszlo Farkas, Benjamin Van Tassell, Donatas Kraskauskas, Shiro Mizuno, Antonio Abbate, Harm J Bogaard, Peter R Byron, Norbert F Voelkel
Prostacyclin and its analogues improve cardiac output and functional capacity in patients with pulmonary arterial hypertension (PAH); however, the underlying mechanism is not fully understood. We hypothesised that prostanoids have load-independent beneficial effects on the right ventricle (RV). Angio-obliterative PAH and RV failure were induced in rats with a single injection of SU5416 followed by 4 weeks of exposure to hypoxia. Upon confirmation of RV dysfunction and PAH, rats were randomised to 0.1 μg·kg(-1) nebulised iloprost or drug-free vehicle, three times daily for 2 weeks...
February 2015: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
José D Ordóñez-Gómez, Víctor Arroyo-Rodríguez, Sergio Nicasio-Arzeta, Jurgi Cristóbal-Azkarate
Understanding the response of species to changes in landscape configuration is required to design adequate management and conservation strategies. Yet, the most appropriate spatial scale (i.e., landscape size) to assess the response of species to changes in landscape configuration (so-called "scale of effect") is largely unknown. In this paper, we assess the impact of landscape forest cover, forest fragmentation, edge density, and inter-patch isolation distance on the diet and behavior of six communities of spider monkeys (Ateles geoffroyi) in the fragmented Lacandona rainforest, Mexico...
January 2015: American Journal of Primatology
Jose Gomez-Arroyo, Julio Sandoval, Marc A Simon, Erick Dominguez-Cano, Norbert F Voelkel, Harm J Bogaard
Pulmonary arterial hypertension (PAH) includes a heterogeneous group of diseases characterized by pulmonary vasoconstriction and remodeling of the lung circulation. Although PAH is a disease of the lungs, patients with PAH frequently die of right heart failure. Indeed, survival of patients with PAH depends on the adaptive response of the right ventricle (RV) to the changes in the lung circulation. PAH-specific drugs affect the function of the RV through afterload reduction and perhaps also through direct effects on the myocardium...
September 2014: Annals of the American Thoracic Society
Michiel Alexander De Raaf, Aysar Al Hussaini, Jose Gomez-Arroyo, Donatas Kraskaukas, Daniela Farkas, Chris Happé, Norbert F Voelkel, Harm Jan Bogaard
Pulmonary arterial hypertension (PAH) is a rapidly progressive and devastating disease characterized by remodeling of lung vessels, increased pulmonary vascular resistance, and eventually right ventricular hypertrophy and failure. Because histone deacetylase (HDAC) inhibitors are agents hampering tumor growth and cardiac hypertrophy, they have been attributed a therapeutic potential for patients with PAH. Outcomes of studies evaluating the use of HDAC inhibitors in models of PAH and right ventricular pressure overload have been equivocal, however...
June 2014: Pulmonary Circulation
Vanessa Moreno, Pilar Gonzalo, Jesús Gómez-Escudero, Ángela Pollán, Rebeca Acín-Pérez, Mark Breckenridge, María Yáñez-Mó, Olga Barreiro, Fabrizio Orsenigo, Kenji Kadomatsu, Christopher S Chen, José A Enríquez, Elisabetta Dejana, Francisco Sánchez-Madrid, Alicia G Arroyo
Cell-cell adhesions are important sites through which cells experience and resist forces. In endothelial cells, these forces regulate junction dynamics and determine endothelial barrier strength. We identify the Ig superfamily member EMMPRIN (also known as basigin) as a coordinator of forces at endothelial junctions. EMMPRIN localization at junctions correlates with endothelial junction strength in different mouse vascular beds. Accordingly, EMMPRIN-deficient mice show altered junctions and increased junction permeability...
September 1, 2014: Journal of Cell Science
Norbert F Voelkel, Jose Gomez-Arroyo
Pulmonary arterial hypertension (PAH) is characterized by dysfunctional angiogenesis leading to lung vessel obliteration. PAH is widely considered a proangiogenic disease; however, the role of angiogenic factors, such as the vascular endothelial growth factor (VEGF) and its receptors, in the pathobiology of PAH remains incompletely understood. This Review attempts to untangle some of the complex multilayered actions of VEGF to provide a VEGF-centered perspective of PAH. Furthermore, we provide a cogent explanation for the paradox of VEGF receptor blockade-induced pulmonary hypertension that characterizes the SU5416-hypoxia rat model of PAH, and attempt to translate the knowledge gained from the experimental model to the human disease by postulating the potential role of endogenous (SU5416-like) VEGF inhibitors...
October 2014: American Journal of Respiratory Cell and Molecular Biology
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