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https://www.readbyqxmd.com/read/28810146/swarm-intelligence-enhanced-detection-of-non-small-cell-lung-cancer-using-tumor-educated-platelets
#1
Myron G Best, Nik Sol, Sjors G J G In 't Veld, Adrienne Vancura, Mirte Muller, Anna-Larissa N Niemeijer, Aniko V Fejes, Lee-Ann Tjon Kon Fat, Anna E Huis In 't Veld, Cyra Leurs, Tessa Y Le Large, Laura L Meijer, Irsan E Kooi, François Rustenburg, Pepijn Schellen, Heleen Verschueren, Edward Post, Laurine E Wedekind, Jillian Bracht, Michelle Esenkbrink, Leon Wils, Francesca Favaro, Jilian D Schoonhoven, Jihane Tannous, Hanne Meijers-Heijboer, Geert Kazemier, Elisa Giovannetti, Jaap C Reijneveld, Sander Idema, Joep Killestein, Michal Heger, Saskia C de Jager, Rolf T Urbanus, Imo E Hoefer, Gerard Pasterkamp, Christine Mannhalter, Jose Gomez-Arroyo, Harm-Jan Bogaard, David P Noske, W Peter Vandertop, Daan van den Broek, Bauke Ylstra, R Jonas A Nilsson, Pieter Wesseling, Niki Karachaliou, Rafael Rosell, Elizabeth Lee-Lewandrowski, Kent B Lewandrowski, Bakhos A Tannous, Adrianus J de Langen, Egbert F Smit, Michel M van den Heuvel, Thomas Wurdinger
Blood-based liquid biopsies, including tumor-educated blood platelets (TEPs), have emerged as promising biomarker sources for non-invasive detection of cancer. Here we demonstrate that particle-swarm optimization (PSO)-enhanced algorithms enable efficient selection of RNA biomarker panels from platelet RNA-sequencing libraries (n = 779). This resulted in accurate TEP-based detection of early- and late-stage non-small-cell lung cancer (n = 518 late-stage validation cohort, accuracy, 88%; AUC, 0.94; 95% CI, 0...
August 14, 2017: Cancer Cell
https://www.readbyqxmd.com/read/28722631/dengue-virus-coinfection-in-human-immunodeficiency-virus-1-infected-patients-on-the-west-coast-of-mexico
#2
Francisco Espinoza-Gómez, Iván Delgado-Enciso, Salvador Valle-Reyes, Rodolfo Ochoa-Jiménez, Conrado Arechiga-Ramírez, José L Gámez-Arroyo, Roberto Vázquez-Campuzano, Carmen Guzmán-Bracho, Clemente Vásquez, Uriel A López-Lemus
Dengue virus infection in human immunodeficiency virus (HIV)-positive patients is not well studied. Previous reports suggest a transitory inhibition of the HIV-1 viral load, as well as a benign clinical progression of dengue. The follow-up of six HIV-1-infected patients, diagnosed and hospitalized with dengue virus infection in the State of Colima, Mexico, was carried out to analyze the progression of this viral coinfection. The presence of dengue virus serotype 1 was confirmed through molecular tests. No severe complications were observed in any of the patients during dengue virus infection...
June 12, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28608996/prognostic-value-of-event-free-survival-at-12-and-24-months-and-long-term-mortality-for-non-hodgkin-follicular-lymphoma-patients-a-study-report-from-the-spanish-lymphoma-oncology-group
#3
Mariano Provencio, Ana Royuela, María Torrente, Marina Pollán, José Gómez-Codina, Pilar Sabín, Marta Llanos, Josep Gumá, Cristina Quero, Ana Blasco, David Aguiar, Francisco Ramón García-Arroyo, Javier Lavernia, Natividad Martínez, Manuel Morales, Álvaro Saenz-Cusi, Delvys Rodríguez, Virginia Calvo, Luis de la Cruz-Merino, Miguel Ángel de la Cruz, Antonio Rueda
BACKGROUND: Relatively few studies have analyzed the mortality of follicular lymphoma (FL) patients in comparison with a sex- and age-matched general population. This study analyzed the overall survival (OS) of patients with FL and compared their survival with the expected survival of a general population. METHODS: Patients diagnosed with FL were prospectively enrolled from 1980 to 2013. Standardized mortality ratios (SMRs) were obtained from yearly sex- and age-specific mortality rates in Spain, and OS was compared with age- and sex-matched general population data...
June 13, 2017: Cancer
https://www.readbyqxmd.com/read/28573526/selecting-embryos-with-the-highest-implantation-potential-using-data-mining-and-decision-tree-based-on-classical-embryo-morphology-and-morphokinetics
#4
Beatriz Carrasco, Gemma Arroyo, Yolanda Gil, Mª José Gómez, Ignacio Rodríguez, Pedro N Barri, Anna Veiga, Montserrat Boada
PURPOSE: The objective of this work was to determine which embryonic morphokinetic parameters up to D3 of in vitro development have predictive value for implantation for the selection of embryos for transfer in clinical practice based upon information generated from embryo transfers with known implantation data (KID). METHODS: A total of 800 KID embryos (100% implantation rate (IR) per transfer and 0% IR per transfer) cultured in an incubator with Time-Lapse system were retrospectively analysed...
August 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28493986/impact-of-treatment-in-long-term-survival-patients-with-follicular-lymphoma-a-spanish-lymphoma-oncology-group-registry
#5
Mariano Provencio, Pilar Sabín, Jose Gomez-Codina, Maria Torrente, Virginia Calvo, Marta Llanos, Josep Gumá, Cristina Quero, Ana Blasco, Miguel Angel Cruz, David Aguiar, Francisco García-Arroyo, Javier Lavernia, Natividad Martinez, Manuel Morales, Alvaro Saez-Cusi, Delvys Rodriguez, Luis de la Cruz, Jose Javier Sanchez, Antonio Rueda
BACKGROUND: Follicular lymphoma is the second most common non-Hodgkin lymphoma in the United States and Europe. However, most of the prospective randomized studies have very little follow-up compared to the long natural history of the disease. The primary aim of this study was to investigate the long-term survival of our series of patients with follicular lymphoma. PATIENTS AND METHODS: A total of 1074 patients with newly diagnosed FL were enrolled. Patients diagnosed were prospectively enrolled from 1980 to 2013...
2017: PloS One
https://www.readbyqxmd.com/read/28315337/p53-signaling-pathway-polymorphisms-associated-with-emphysematous-changes-in-patients-with-copd
#6
Shiro Mizuno, Takeshi Ishizaki, Maiko Kadowaki, Masaya Akai, Kohei Shiozaki, Masaharu Iguchi, Taku Oikawa, Ken Nakagawa, Kazuhiro Osanai, Hirohisa Toga, Jose Gomez-Arroyo, Donatas Kraskauskas, Carlyne D Cool, Herman J Bogaard, Norbert F Voelkel
BACKGROUND: The p53 signaling pathway may be important for the pathogenesis of emphysematous changes in the lungs of smokers. Polymorphism of p53 at codon 72 is known to affect apoptotic effector proteins, and the polymorphism of mouse double minute 2 homolog (MDM2) single nucleotide polymorphism (SNP)309 is known to increase MDM2 expression. The aim of this study was to assess polymorphisms of the p53 and MDM2 genes in smokers and confirm the role of SNPs in these genes in the pathogenesis of pulmonary emphysema...
July 2017: Chest
https://www.readbyqxmd.com/read/28033107/genotoxic-effects-of-the-carbamate-insecticide-pirimor-50%C3%A2-in-vicia-faba-root-tip-meristems-and-human-lymphocyte-culture-after-direct-application-and-treatment-with-its-metabolic-extracts
#7
Rafael Valencia-Quintana, Sandra Gómez-Arroyo, Juana Sánchez-Alarcón, Mirta Milić, José Luis Gómez Olivares, Stefan M Waliszewski, Josefina Cortés-Eslava, Rafael Villalobos-Pietrini, María Elena Calderón-Segura
The aim of the study was to evaluate genotoxic effects of Pirimor-50®, a pirimicarb-based formulation (50 % active ingredient), in human lymphocyte cultures and Vicia faba root meristems. Furthermore, the objective was to examine a combined influence of insecticide treatment with mammalian microsomal S9 and vegetal S10 metabolic fractions or S10 mix metabolic transformation extracts (after Vicia faba primary roots treatment with Pirimor-50®). We used sister chromatid exchange assay-SCE and measured cell cycle progression and proliferation (proportion of M1-M3 metaphases and replication index ratio-RI)...
December 1, 2016: Arhiv za Higijenu Rada i Toksikologiju
https://www.readbyqxmd.com/read/27970282/tct-120-primary-angioplasty-for-patients-over-75-years-old-in-cardiogenic-shock-contemporary-results-and-prognostic-predictors-from-the-estrofa-mi-75-nationwide-registry
#8
Jose M de la Torre Hernandez, Salvatore Brugaletta, Joan Antoni Gomez Hospital, Jose Antonio Baz, Armando Perez de Prado, Ramon Lopez Palop, Ana Belen Cid Alvarez, Tamara Garcia Camarero, Alejandro Diego Nieto, Federico Gimeno, Jose Antonio Fernandez Diaz, Juan Sanchis Fores, Fernando Alfonso, Roberto Blanco, Javier Botas, Javier Navarro Cuartero, Jose Moreu Burgos, Francisco Bosa, Jose Miguel Vegas, Jaime Elizaga, Antonio Luis Arrebola Moreno, Jose R Ruiz Arroyo, Felipe Hernandez, Neus Salvatella Giralt, Marta Monteagudo, Alfredo Gomez Jaume, Xavier Carrillo, Roberto Martin-Reyes, Fernando Lozano, Jose Rumoroso, Leire Andraka, Antonio J Dominguez
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27847267/primary-breast-lymphoma-analysis-of-55-cases-of-the-spanish-lymphoma-oncology-group
#9
Fernando Franco Pérez, Javier Lavernia, David Aguiar-Bujanda, José Miramón, Josep Gumá, Rut Álvarez, José Gómez-Codina, Francisco García Arroyo, Marta Llanos, Miguel Marin, Jesus Alfaro, Cristina Quero, Mayte Delgado, Esteban Nogales, Francisco Menarguez, Natividad Martinez, Maria Torrente, Ana Royuela, Delvys Abreu, Mariano Provencio
INTRODUCTION: Primary breast lymphoma is a rare form of localized extranodal lymphoma, which affects the mammary glands unilaterally or bilaterally, and can also affect the regional lymph nodes. MATERIALS AND METHODS: We reviewed 55 patients, with disease stages IE and IIE, diagnosed in 16 Spanish institutions between 1989 and 2016. A serial of clinical variables and treatment were collected, and overall survival (OS) and progression-free survival (PFS) were calculated...
March 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/27478186/pulmonary-arterial-hypertension-and-the-enigma-code-of-smouldering-inflammation
#10
EDITORIAL
Jose Gomez-Arroyo, Antonio Abbate, Norbert F Voelkel
No abstract text is available yet for this article.
August 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/27436834/reaction-to-synthetic-membranes-in-hemodialysis
#11
Silvia González Sanchidrián, Pedro Jesús Labrador Gómez, Jesús Pedro Marín Álvarez, María Carmen Jiménez Herrero, Inés Castellano Cerviño, Sandra Gallego Domínguez, José María Sánchez-Montalbán, Javier Deira Lorenzo, Elena Davin Carrero, Santiago Polanco Candelario, Juan Ramón Gómez-Martino Arroyo
No abstract text is available yet for this article.
November 2016: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/27331299/assessment-of-genotoxicity-of-lannate-90%C3%A2-and-its-plant-and-animal-metabolites-in-human-lymphocyte-cultures
#12
COMPARATIVE STUDY
Rafael Valencia-Quintana, Sandra Gómez-Arroyo, Juana Sánchez-Alarcón, Mirta Milić, José Luis Gómez Olivares, Stefan M Waliszewski, Josefina Cortés-Eslava, Rafael Villalobos-Pietrini, María Elena Calderón-Segura
This study evaluated direct and metabolic genotoxic effects caused by Lannate-90®, a methomyl-based formulation (90 % active ingredient), in human lymphocyte cultures using sister chromatid exchange assay (SCE). Two processes were used for the plant promutagens evaluation: in vivo activation, applying the insecticide systemically in plants for 4 h and subsequently adding plant metabolites containing extracts to lymphocyte cultures; and in vitro activation, where the insecticide was incubated with Vicia faba S10 mix plus human lymphocyte culture...
June 1, 2016: Arhiv za Higijenu Rada i Toksikologiju
https://www.readbyqxmd.com/read/26901767/proximal-and-distal-predictors-of-the-spider-monkey-s-stress-levels-in-fragmented-landscapes
#13
José D Ordóñez-Gómez, Jurgi Cristóbal-Azkarate, Víctor Arroyo-Rodríguez, Ana M Santillán-Doherty, Ricardo A Valdez, Marta C Romano
The rapid loss, fragmentation and degradation of tropical forests threaten the survival of many animal species. However, the way in which these phenomena affect animal health has been poorly explored, thus limiting the design of appropriate conservation strategies. To address this, here we identified using linear mixed models the effect of proximal (diet, activity pattern, hunting and logging) and distal (sum of the basal areas of fruiting-tree species [SBAFS], landscape forest cover and degree of forest fragmentation) variables over fecal glucocorticoid metabolite (fGCM) levels-hormones associated with animal health and fitness-of six groups of spider monkeys (Ateles geoffroyi) inhabiting six landscapes with different spatial structures in Mexico...
2016: PloS One
https://www.readbyqxmd.com/read/26813890/dietary-%C3%AE-linolenic-acid-marine-%C3%AF-3-fatty-acids-and-mortality-in-a-population-with-high-fish-consumption-findings-from-the-prevenci%C3%A3-n-con-dieta-mediterr%C3%A3-nea-predimed-study
#14
RANDOMIZED CONTROLLED TRIAL
Aleix Sala-Vila, Marta Guasch-Ferré, Frank B Hu, Ana Sánchez-Tainta, Mònica Bulló, Mercè Serra-Mir, Carmen López-Sabater, Jose V Sorlí, Fernando Arós, Miquel Fiol, Miguel A Muñoz, Luis Serra-Majem, J Alfredo Martínez, Dolores Corella, Montserrat Fitó, Jordi Salas-Salvadó, Miguel A Martínez-González, Ramón Estruch, Emilio Ros, B
BACKGROUND: Epidemiological evidence suggests a cardioprotective role of α-linolenic acid (ALA), a plant-derived ω-3 fatty acid. It is unclear whether ALA is beneficial in a background of high marine ω-3 fatty acids (long-chain n-3 polyunsaturated fatty acids) intake. In persons at high cardiovascular risk from Spain, a country in which fish consumption is customarily high, we investigated whether meeting the International Society for the Study of Fatty Acids and Lipids recommendation for dietary ALA (0...
January 26, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/26336164/increased-phosphorylation-of-the-renal-na-cl-cotransporter-in-male-kidney-transplant-recipient-patients-with-hypertension-a-prospective-cohort
#15
Lorena Rojas-Vega, Aldo R Jiménez-Vega, Silvana Bazúa-Valenti, Isidora Arroyo-Garza, José Victor Jiménez, Ruy Gómez-Ocádiz, Diego Luis Carrillo-Pérez, Erika Moreno, Luis E Morales-Buenrostro, Josefina Alberú, Gerardo Gamba
Evidence in rodents suggests that tacrolimus-induced posttransplant hypertension is due to upregulation of the thiazide-sensitive Na+-Cl- cotransporter NCC. Here, we analyzed whether a similar mechanism is involved in posttransplant hypertension in humans. From January 2013 to June 2014, all adult kidney transplant recipients receiving a kidney allograft were enrolled in a prospective cohort study. All patients received tacrolimus as part of the immunosuppressive therapy. Six months after surgery, we assessed general clinical and laboratory variables, tacrolimus trough blood levels, and ambulatory 24-h blood pressure monitoring...
November 15, 2015: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/26233973/-non-invasive-prenatal-test-nipt-in-maternal-blood-by-parallel-massive-sequencing-initial-experience-in-mexican-women-and-literature-review
#16
REVIEW
Mariana Hernández-Gómez, Eva Ramirez-Arroyo, Ricardo Meléndez-Hernández, Luz Maria Garduño-Zaraza, Dora Gilda Mayén-Molina
BACKGROUND: Discovery of cell-free fetal DNA (cffDNA) in maternal blood in 1997 by Lo et al. has opened the possibility of a noninvasive prenatal test (NIPT). Currently, it is employed in the analysis of aneuploidies and fetal sex determination. Massive parallel sequencing (MPS) detects the origin of each amplified sequence, and analyses over-representation of sequences or any decrease in the fetal chromosomes in maternal plasma. This technique has been validated and allows assessment of trisomies 13, 18 and 21, obtaining the result in about a week from 10-weeks of gestational age...
May 2015: Ginecología y Obstetricia de México
https://www.readbyqxmd.com/read/26090341/comparison-of-sublingual-therapeutic-vaccine-with-antibiotics-for-the-prophylaxis-of-recurrent-urinary-tract-infections
#17
María F Lorenzo-Gómez, Bárbara Padilla-Fernández, María B García-Cenador, Álvaro J Virseda-Rodríguez, Isidoro Martín-García, Alfonso Sánchez-Escudero, Manuel J Vicente-Arroyo, José A Mirón-Canelo
OBJECTIVE: To compare the clinical impact of a prophylactic treatment with sublingual immunostimulation in the prevention of recurrent urinary tract infections (rUTIs) with the use of antibiotics. MATERIAL AND METHODS: Retrospective cohort study evaluating the medical records of 669 women with rUTIs; 339 had a 6-month prophylaxis with antibiotics and 360 a 3-month prophylaxis with a sublingual bacterial preparation (MV 140-Uromune®). The time frame after the prophylaxis-period until the appearance of a new infection (assessed by uroculture) was scored and followed during 1 year...
2015: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/25992273/the-need-to-recognize-the-pulmonary-circulation-and-the-right-ventricle-as-an-integrated-functional-unit-facts-and-hypotheses-2013-grover-conference-series
#18
REVIEW
Norbert F Voelkel, Harm Jan Bogaard, Jose Gomez-Arroyo
For many patients with severe pulmonary arterial hypertension, heart failure-and, in particular, right heart failure-is the final chapter of their chronic illness. Targeted therapy for pulmonary hypertension is effective only if the right ventricular ejection fraction is maintained or improved. Because improvement of right heart function and reversal of right heart failure are treatment goals, it is important to investigate the cellular and molecular mechanisms that cause right heart failure. Here, we propose that right ventricular capillary rarefaction is an important hallmark of right heart failure and consider that the "sick lung circulation" and the pressure-overloaded right ventricle constitute a functional unit...
March 2015: Pulmonary Circulation
https://www.readbyqxmd.com/read/25965325/scope-and-limitations-of-the-liebeskind-srogl-cross-coupling-reactions-involving-the-biellmann-bodipy
#19
Lourdes Betancourt-Mendiola, Ismael Valois-Escamilla, Teresa Arbeloa, Jorge Bañuelos, Iñigo López Arbeloa, Juan O Flores-Rizo, Rongrong Hu, Erik Lager, César F A Gómez-Durán, José L Belmonte-Vázquez, Mayra R Martínez-González, Ismael J Arroyo, Carlos A Osorio-Martínez, Enrique Alvarado-Martínez, Arlette Urías-Benavides, Brenda D Gutiérrez-Ramos, Ben Zhong Tang, Eduardo Peña-Cabrera
Several new examples of meso-(het)arylBODIPY were prepared via the Liebeskind-Srogl (L-S) cross-coupling reaction of the Biellmann BODIPYs (1a,b) and aryl- and heteroarylboronic acids in good to excellent yield. It was shown that this reaction could be carried out under microwave heating to shorten reaction times and/or increase the yield. It was illustrated that organostannanes also participate in the L-S reaction to give the corresponding BODIPY analogues in short reaction times and also with good to excellent yields...
June 5, 2015: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/25899426/deletion-1q43-44-in-a-patient-with-clinical-diagnosis-of-warburg-micro-syndrome
#20
Ignacio Arroyo-Carrera, María Solo de Zaldívar Tristancho, Eva Bermejo-Sánchez, María Luisa Martínez-Fernández, Amparo López-Lafuente, Alexandra MacDonald, Ángel Zúñiga, José Luis Gómez-Skarmeta, María Luisa Martínez-Frías
Warburg-Micro syndrome (WARBM) is an autosomal recessive syndrome characterized by microcephaly, microphthalmia, microcornea, congenital cataracts, optic atrophy and central nervous system malformations. This syndrome is caused by mutations in the RAB3GAP1/2 and RAB18 genes, part of the Rab family, and in the TBC1D20 gene, which contributes to lipid droplet formation/metabolism. Here we present a patient with clinical diagnosis of WARBM syndrome, who did not have mutations in either the RAB3GAP1/2 genes, in the main exons of RAB18, nor in the TBC1D20 gene...
June 2015: American Journal of Medical Genetics. Part A
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