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Gene environment interactions

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https://www.readbyqxmd.com/read/29031184/gene-environment-interactions-between-stress-and-5-httlpr-in-depression-a-meta-analytic-update
#1
REVIEW
Dries Bleys, Patrick Luyten, Bart Soenens, Stephan Claes
BACKGROUND: Meta-analyses have yielded contradictory findings concerning the role of 5-HTTLPR in interaction with stress (GxE) in depression. The current meta-analysis investigates if these contradictory findings are a result of differences between studies in methodological approaches towards the assessment of stress and depression. METHODS: After performing a systematic database search (February to December 2016), first, a meta-analysis was used to investigate the total effect size and publication bias...
October 3, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29028686/interaction-between-catalase-gene-promoter-polymorphisms-and-indoor-environmental-exposure-in-childhood-allergic-rhinitis
#2
Hsin-I Chen, Yu-Ting Lin, Chau-Ren Jung, Bing-Fang Hwang
BACKGROUND: Allergic rhinitis (AR) is a highly prevalent chronic inflammatory disease affecting nearly 40% of the children in Taiwan. Genetic susceptibility may interact with specific environmental factors leading to allergic disease development. METHODS: To assess the interactions between catalase gene promoter polymorphisms and environmental factors on the risk of AR, we conducted a case-control study in Taiwan. Data on AR and environmental factors were collected from 800 children using the ISSAC questionnaire...
October 2017: Epidemiology
https://www.readbyqxmd.com/read/29028070/gene-expression-in-human-adipose-derived-stem-cells-comparison-of-2d-films-3d-electrospun-meshes-or-co-cultured-scaffolds-with-two-way-paracrine-effects
#3
S C Hess, W J Stark, D Mohn, N Cohrs, S Märsmann, M Calcagni, P Cinelli, J Buschmann
Finding the appropriate cues to trigger the desired differentiation is a challenge in tissue engineering when stem cells are involved. In this regard, three-dimensional environments are often compared to cells' two-dimensional culture behaviour (plastic culture dish). Here, we compared the gene expression pattern of human adipose-derived stem cells (ASC) seeded in a three-dimensional (3D) electrospun mesh and on a two-dimensional (2D) film - both of exactly the same material. Additionally, we conducted experiments with a scaffold floating above a film to investigate two-way paracrine effects (co-system)...
October 13, 2017: European Cells & Materials
https://www.readbyqxmd.com/read/29027484/cyp1a1-expression-and-organochlorine-pesticides-level-in-the-etiology-of-bladder-cancer-in-north-indian-population
#4
H Verma, T Sharma, S Gupta, B D Banerjee
Urinary bladder cancer (UBC) is one of the most common malignancies worldwide. The etiology of UBC is multifactorial and includes both exogenous and endogenous factors. Exogenous risk factors include exposure to heavy metals, aromatic amines, and environmental pollutants including pesticides such as organochlorine pesticides (OCPs). Environmental factors alone are incapable of directly producing DNA damage and may require activation by phase I metabolizing enzymes like cytochrome P450 in order to become active carcinogen...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/29021401/rnaseq-analysis-of-differentiated-keratinocytes-reveals-a-massive-response-to-late-events-during-human-papillomavirus-type-16-infection-including-loss-of-epithelial-barrier-function
#5
T Klymenko, Q Gu, I Herbert, A Stevenson, V Iliev, G Watkins, C Pollock, R Bhatia, K Cuschieri, P Herzyk, D Gatherer, S V Graham
The human papillomavirus (HPV) replication cycle is tightly linked to epithelial cell differentiation. To examine HPV-associated changes in the keratinocyte transcriptome, RNAs isolated from undifferentiated and differentiated cell populations of normal, spontaneously immortalised, keratinocytes (NIKS), and NIKS stably transfected with HPV16 episomal genomes (NIKS16), were compared using RNASeq. HPV16 infection altered expression of 2862 cellular genes. Next, to elucidate the role of keratinocyte gene expression in late events during the viral life cycle, RNASeq was carried out on triplicate differentiated populations of NIKS (uninfected) and NIKS16 (infected)...
October 11, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29020749/the-draft-genome-assembly-of-rhododendron-delavayi-franch-var-delavayi
#6
Lu Zhang, Pengwei Xu, Yanfei Cai, Lulin Ma, Shifeng Li, Shufa Li, Weijia Xie, Jie Song, Lvchun Peng, Huijun Yan, Ling Zou, Yongpeng Ma, Chengjun Zhang, Qiang Gao, Jihua Wang
Rhododendron delavayi Franch. is globally famous as an ornamental plant. Its distribution in southwest China covers several different habitats and environments. However, not much research had been conducted on Rhododendron spp. at the molecular level, which hinders understanding of its evolution, speciation, and synthesis of secondary metabolites, as well as its wide adaptability to different environments. Here, we report the genome assembly and gene annotation of R. delavayi var. delavayi (the second genome sequenced in the Ericaceae), which will facilitate the study of the family...
October 1, 2017: GigaScience
https://www.readbyqxmd.com/read/29020443/the-solution-conformation-of-polymer-brushes-determines-their-interactions-with-dna-and-transfection-efficiency
#7
Mahentha Krishnamoorthy, Danyang Li, Amir S Sharili, Tina Gulin-Sarfraz, Jessica M Rosenholm, Julien Ezra Gautrot
Polymer brush-functionalised nanomaterials offer interesting features for the design of gene delivery vectors as their physico-chemical and structural properties can be designed independently of the chemistry, size and shape of the nanomaterial core. However, little is known of the parameters regulating the adsorption and infiltration of DNA molecules at the surface of positively charged polymer brushes, despite the importance of such processes for gene delivery. Here we investigate the role of the molecular environment (e...
October 11, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/29018430/preliminary-transcriptome-analysis-of-mature-biofilm-and-planktonic-cells-of-salmonella-enteritidis-exposure-to-acid-stress
#8
Kun Jia, Guangyu Wang, Lijiao Liang, Meng Wang, Huhu Wang, Xinglian Xu
Salmonella has emerged as a well-recognized food-borne pathogen, with many strains able to form biofilms and thus cause cross-contamination in food processing environments where acid-based disinfectants are widely encountered. In the present study, RNA sequencing was employed to establish complete transcriptome profiles of Salmonella Enteritidis in the forms of planktonic and biofilm-associated cells cultured in Tryptic Soytone Broth (TSB) and acidic TSB (aTSB). The gene expression patterns of S. Enteritidis significantly differed between biofilm-associated and planktonic cells cultivated under the same conditions...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29017894/rotavirus-encoded-virus-like-small-rna-triggers-autophagy-by-targeting-igf1r-via-the-pi3k-akt-mtor-pathway
#9
Yan Zhou, Panpan Geng, Yalin Liu, Jinyuan Wu, Hongtu Qiao, Yuping Xie, Na Yin, Linlin Chen, Xiaochen Lin, Yang Liu, Shan Yi, Guangming Zhang, Hongjun Li, Maosheng Sun
Rotaviruses are double-stranded RNA viruses that are a major cause of viral diarrhea in infants. Examining virus-host cell interaction is important for elucidating mechanisms of virus proliferation in host cells. Viruses can create an environment that promotes their survival and self-proliferation by encoding miRNAs or miRNA-like molecules that target various host cell. However, it remains unclear whether RNA viruses encode viral miRNAs, and their regulation mechanisms are largely unknown. We previously performed deep sequencing analysis to investigate rotavirus-encoded miRNAs, and identified the small RNA molecule Chr17_1755, which we named RV-vsRNA1755...
October 7, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29016970/a-genome-by-environment-interaction-classifier-for-precision-medicine-personal-transcriptome-response-to-rhinovirus-identifies-children-prone-to-asthma-exacerbations
#10
Vincent Gardeux, Joanne Berghout, Ikbel Achour, A Grant Schissler, Qike Li, Colleen Kenost, Jianrong Li, Yuan Shang, Anthony Bosco, Donald Saner, Marilyn J Halonen, Daniel J Jackson, Haiquan Li, Fernando D Martinez, Yves A Lussier
Objective: To introduce a disease prognosis framework enabled by a robust classification scheme derived from patient-specific transcriptomic response to stimulation. Materials and Methods: Within an illustrative case study to predict asthma exacerbation, we designed a stimulation assay that reveals individualized transcriptomic response to human rhinovirus. Gene expression from peripheral blood mononuclear cells was quantified from 23 pediatric asthmatic patients and stimulated in vitro with human rhinovirus...
November 1, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29016655/meta-analysis-of-peripheral-blood-gene-expression-modules-for-copd-phenotypes
#11
Dominik Reinhold, Jarrett D Morrow, Sean Jacobson, Junxiao Hu, Benjamin Ringel, Max A Seibold, Craig P Hersh, Katerina J Kechris, Russell P Bowler
Chronic obstructive pulmonary disease (COPD) occurs typically in current or former smokers, but only a minority of people with smoking history develops the disease. Besides environmental factors, genetics is an important risk factor for COPD. However, the relationship between genetics, environment and phenotypes is not well understood. Sample sizes for genome-wide expression studies based on lung tissue have been small due to the invasive nature of sample collection. Increasing evidence for the systemic nature of the disease makes blood a good alternative source to study the disease, but there have also been few large-scale blood genomic studies in COPD...
2017: PloS One
https://www.readbyqxmd.com/read/28993643/a-sexually-dimorphic-pre-stressed-translational-signature-in-ca3-pyramidal-neurons-of-bdnf-val66met-mice
#12
Jordan Marrocco, Gordon H Petty, Mariel B Ríos, Jason D Gray, Joshua F Kogan, Elizabeth M Waters, Eric F Schmidt, Francis S Lee, Bruce S McEwen
Males and females use distinct brain circuits to cope with similar challenges. Using RNA sequencing of ribosome-bound mRNA from hippocampal CA3 neurons, we found remarkable sex differences and discovered that female mice displayed greater gene expression activation after acute stress than males. Stress-sensitive BDNF Val66Met mice of both sexes show a pre-stressed translational phenotype in which the same genes that are activated without applied stress are also induced in wild-type mice by an acute stressor...
October 9, 2017: Nature Communications
https://www.readbyqxmd.com/read/28993269/hydrogen-peroxide-resistance-in-strigomonas-culicis-effects-on-mitochondrial-functionality-and-aedes-aegypti-interaction
#13
Ana Cristina Souza Bombaça, Felipe de Almeida Dias, Vitor Ennes-Vidal, Aline Dos Santos Garcia-Gomes, Marcos Henrique Ferreira Sorgine, Claudia Masini d'Avila-Levy, Rubem Figueiredo Sadok Menna-Barreto
Reactive oxygen species (ROS) are toxic molecules involved in several biological processes such as cellular signaling, proliferation, differentiation and cell death. Adaptations to oxidative environments are crucial for the success of the colonization of insects by protozoa. Strigomonas culicis is a monoxenic trypanosomatid found in the midgut of mosquitoes and presenting a life cycle restricted to the epimastigote form. Among S. culicis peculiarities, there is an endosymbiotic bacterium in the cytoplasm, which completes essential biosynthetic routes of the host cell and may represent an intermediary evolutive step in organelle origin, thus constituting an interesting model for evolutive researches...
October 7, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28992739/pharmacogenetic-and-pharmacogenomic-considerations-of-asthma-treatment
#14
Maria Gabriella Matera, Barbara Rinaldi, Luigino Calzetta, Mario Cazzola
Pharmacogenetic and pharmacogenomic approaches are already utilized in some areas, such as oncology and cardiovascular disease, for selecting appropriate patients and/or establishing treatment and dosing guidelines. This is not true in asthma although many patients have different responses to drug treatment due to genetic factors. Areas covered: Several genetic factors that affect the pharmacotherapeutic responses to asthma medications, such as β2-AR agonists, corticosteroids, and leukotriene modifiers and could contribute to significant between-person variability in response are described...
October 10, 2017: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/28992386/interaction-between-the-%C3%AE-opioid-receptor-gene-and-the-number-of-heavy-drinking-peers-on-alcohol-use
#15
Michelle J Zaso, Stephen A Maisto, Stephen J Glatt, John M Belote, Aesoon Park
BACKGROUND: The presence of heavy drinking peers may trigger genetic vulnerabilities to alcohol use. Limited correlational findings, albeit mixed as a function of age, suggest that carriers of a μ-opioid receptor (OPRM1) G allele may be more vulnerable than noncarriers to alcohol-promoting perceived peer environments. However, research has not yet examined such genetic susceptibility to actual (rather than perceived) peer environments through an experimental, ad libitum alcohol administration design...
October 9, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28992371/the-impact-of-the-omics-era-on-the-knowledge-and-use-of-lysobacter-spp-to-control-phytopathogenic-microorganisms
#16
REVIEW
Gerardo Puopolo, Selena Tomada, Ilaria Pertot
Omics technologies have had a tremendous impact on under-investigated genera of plant disease biocontrol agents such as Lysobacter. Strong evidence of the association between Lysobacter spp. and the rhizosphere has been obtained through culture independent methods, which has also contributed towards highlighting the relationship between Lysobacter abundance and soil suppressiveness. It is conceivable that the role played by Lysobacter spp. in soil suppressiveness is related to their ability to produce an impressive array of lytic enzymes and antibiotics...
October 9, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28991856/genetic-polymorphisms-in-fatty-acid-metabolism-modify-the-association-between-dietary-n3-n6-intake-and-risk-of-ulcerative-colitis-a-prospective-cohort-study
#17
Ashwin N Ananthakrishnan, Hamed Khalili, Mingyang Song, Leslie M Higuchi, Paul Lochhead, James M Richter, Andrew T Chan
INTRODUCTION: High intake of dietary n-3 polyunsaturated fatty acids (PUFA) is associated with a decreased risk of ulcerative colitis (UC) and Crohn's disease (CD). However, results have been heterogeneous suggesting that genetic variations in PUFA metabolism may modify this risk. METHODS: We conducted a case-control study nested within 2 prospective cohorts, the Nurses' Health Study (NHS) and NHS II. Among women providing blood (n = 62,437) or buccal cells (n = 59,543) for genotyping, we confirmed new diagnoses of CD or UC...
October 6, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28989119/effects-of-protein-coated-nanofibers-on-conformation-of-gingival-fibroblast-spheroids-potential-utility-for-connective-tissues-regeneration
#18
Gili Kaufman, Ryan Whitescarver, Laiz Nunes, Xavier-Lewis Palmer, Drago Skrtic, Wojtek Tutak
Deep wounds in the gingiva caused by trauma or surgery require a rapid and robust healing of connective tissues. We propose utilizing gas-brushed nanofibers coated with collagen and fibrin for that purpose. Our hypotheses are that protein-coated nanofibers will: (i) attract and mobilize cells in various spatial orientations, and (ii) regulate the expression levels of specific extracellular matrix (ECM)-associated proteins, determining the initial conformational nature of dense and soft connective tissues. Gingival fibroblast monolayers and 3D spheroids were cultured on ECM substrate and covered with gas-blown poly-(DL-lactide-co-glycolide) (PLGA) nanofibers (uncoated/coated with collagen and fibrin)...
October 9, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28988974/bdnf-val66met-polymorphism-modulates-the-effect-of-loneliness-on-white-matter-microstructure-in-young-adults
#19
Jie Meng, Lei Hao, Dongtao Wei, Jiangzhou Sun, Yu Li, Jiang Qiu
Loneliness is a common experience. Susceptibility to loneliness is a stable trait and is heritable. Previous studies have suggested that loneliness may impact regional gray matter density and brain activation to social stimuli, but its relation to white matter structure and how it may interact with genetic factors remains unclear. In this study, we investigated whether and how a common polymorphism (Val66Met) in the brain-derived neurotrophic factor gene modulated the association between loneliness and white matter microstructure in 162 young adults...
October 5, 2017: Biological Psychology
https://www.readbyqxmd.com/read/28988247/distinct-penetrance-of-obesity-associated-susceptibility-alleles-in-the-hungarian-general-and-roma-populations
#20
Károly Nagy, Szilvia Fiatal, János Sándor, Róza Ádány
AIMS: The aim of our study was to explore differences in genetic predisposition to obesity between the Hungarian general and Roma populations. METHODS: A total of 1,152 samples from the Hungarian Roma population and 1,743 samples from the Hungarian general population were genotyped for 20 single nucleotide polymorphisms (SNPs) associated with the risk of obesity. Two types of multilocus genetic risk scores were constructed to estimate the combined effect of selected SNPs...
October 7, 2017: Obesity Facts
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