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Gene environment interactions

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https://www.readbyqxmd.com/read/29458203/precision-pharmacology-for-alzheimer-s-disease
#1
REVIEW
Harald Hampel, Andrea Vergallo, Lisi Flores Aguilar, Norbert Benda, Karl Broich, A Claudio Cuello, Jeffrey Cummings, Bruno Dubois, Howard J Federoff, Massimo Fiandaca, Remy Genthon, Marion Haberkamp, Eric Karran, Mark Mapstone, George Perry, Lon S Schneider, Lindsay A Welikovitch, Janet Woodcock, Filippo Baldacci, Simone Lista
The complex multifactorial nature of polygenic Alzheimer's disease (AD) presents significant challenges for drug development. AD pathophysiology is progressing in a non-linear dynamic fashion across multiple systems levels - from molecules to organ systems - and through adaptation, to compensation, and decompensation to systems failure. Adaptation and compensation maintain homeostasis: a dynamic equilibrium resulting from the dynamic non-linear interaction between genome, epigenome, and environment. An individual vulnerability to stressors exists on the basis of individual triggers, drivers, and thresholds accounting for the initiation and failure of adaptive and compensatory responses...
February 16, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29456163/association-of-air-pollution-exposure-and-interleukin-13-haplotype-with-the-risk-of-aggregate-bronchitic-symptoms-in-children
#2
Yungling Leo Lee, Jing-Huei Chen, Chi-Min Wang, Mei-Ling Chen, Bing-Fang Hwang
Interleukin-13(IL-13) might play an important role in driving aggregate bronchitic symptoms pathogenesis. However, none of the studies assessed the interaction between air pollutants exposure and IL-13 gene on the risk of aggregate bronchitic symptoms in non-asthma children. To assess the independent and joint effects of the exposure to air pollution and IL-13 haplotypes on the risk of aggregate bronchitic symptoms, we conducted a cross-sectional study and focused on non-asthma children. The study population consisted of 2944 children...
February 12, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29455459/first-draft-genome-of-an-iconic-clownfish-species-amphiprion-frenatus
#3
Anna Marcionetti, Victor Rossier, Joris A M Bertrand, Glenn Litsios, Nicolas Salamin
Clownfishes (or anemonefishes) form an iconic group of coral reef fishes, principally known for their mutualistic interaction with sea anemones. They are characterized by particular life-history traits, such as a complex social structure and mating system involving sequential hermaphroditism, coupled with an exceptionally long lifespan. Additionally, clownfishes are considered to be one of the rare group to have experienced an adaptive radiation in the marine environment. Here, we assembled and annotated the first genome of a clownfish species, the tomato clownfish (Amphiprion frenatus)...
February 17, 2018: Molecular Ecology Resources
https://www.readbyqxmd.com/read/29454026/adaptation-of-escherichia-coli-to-long-term-batch-culture-in-various-rich-media
#4
Lacey L Westphal, Jasmine Lau, Zuly Negro, Ivan J Moreno, Wazim Ismail Mohammed, Heewook Lee, Haixu Tang, Steven E Finkel, Karin E Kram
Experimental evolution studies have characterized the genetic strategies microbes utilize to adapt to their environments, mainly focusing on how microbes adapt to constant and/or defined environments. Using a system that incubates Escherichia coli in different complex media in long-term batch culture, we have focused on how heterogeneity and environment affects adaptive landscapes. In this system, there is no passaging of cells, and therefore genetic diversity is lost only through negative selection, without the experimentally-imposed bottlenecking common in other platforms...
February 14, 2018: Research in Microbiology
https://www.readbyqxmd.com/read/29454023/interaction-between-hypothermia-and-delayed-mesenchymal-stem-cell-therapy-in-neonatal-hypoxic-ischemic-brain-injury
#5
Josephine Herz, Christian Köster, Barbara S Reinboth, Mark Dzietko, Wiebke Hansen, Hemmen Sabir, Cindy van Velthoven, Ivo Bendix, Ursula Felderhoff-Müser
Acute hypothermia treatment (HT) is the only clinically established intervention following neonatal hypoxic-ischemic brain injury. However, almost half of all cooled infants still die or suffer from long-lasting neurological impairments. Regenerative therapies, such as mesenchymal stem cells (MSC) appear promising as adjuvant therapy. In the present study, we hypothesized that HT combined with delayed MSC therapy results in augmented protection, improving long-term neurological outcome. Postnatal day 9 (P9) C57BL/6 mice were exposed to hypoxia-ischemia followed by 4 hours HT...
February 14, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29453499/screening-for-gene-environment-g%C3%A3-e-interaction-using-omics-data-from-exposed-individuals-an-application-to-gene-arsenic-interaction
#6
Maria Argos, Lin Tong, Shantanu Roy, Mekala Sabarinathan, Alauddin Ahmed, Md Tariqul Islam, Tariqul Islam, Muhammad Rakibuz-Zaman, Golam Sarwar, Hasan Shahriar, Mahfuzar Rahman, Md Yunus, Joseph H Graziano, Farzana Jasmine, Muhammad G Kibriya, Xiang Zhou, Habibul Ahsan, Brandon L Pierce
Identifying gene-environment interactions is a central challenge in the quest to understand susceptibility to complex, multi-factorial diseases. Developing an understanding of how inter-individual variability in inherited genetic variation alters the effects of environmental exposures will enhance our knowledge of disease mechanisms and improve our ability to predict disease and target interventions to high-risk sub-populations. Limited progress has been made identifying gene-environment interactions in the epidemiological setting using existing statistical approaches for genome-wide searches for interaction...
February 16, 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/29453435/evidence-of-a-gene-environment-interaction-of-nodal-variants-and-inflammation-in-preterm-birth
#7
Lisa M Starr, Taghreed Heba, Daniel Dufort
OBJECTIVE: NODAL has been implicated in timing of parturition and immune regulation. We investigated the relationship between NODAL polymorphisms, infection/inflammation, and preterm birth. STUDY DESIGN: For this secondary analysis, 613 women (189 preterm and 424 term) from the Montreal Prematurity Study were genotyped for NODAL polymorphisms and assessed for bacterial vaginosis and placental inflammation. RESULT: NODAL polymorphisms were not associated with preterm birth...
February 16, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29452336/invited-commentary-male-reproductive-system-congenital-malformations-and-the-risk-of-autism-spectrum-disorder
#8
Laura A Schieve, Stuart K Shapira
Autism spectrum disorder (ASD) is a prevalent developmental disorder. Studies indicate that while ASD etiology has a genetic component, the risk is polygenic, with gene-environment interactions being likely. The prenatal period is a critical exposure window for nongenetic risk factors. Previous studies have found positive associations between congenital malformations (all types) and ASD; a few also found specific associations between genitourinary system malformations and ASD; and one study found an association between hypospadias and ASD...
February 14, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29450655/transcription-factors-network-in-root-endosymbiosis-establishment-and-development
#9
REVIEW
Issa Diédhiou, Diaga Diouf
Root endosymbioses are mutualistic interactions between plants and the soil microorganisms (Fungus, Frankia or Rhizobium) that lead to the formation of nitrogen-fixing root nodules and/or arbuscular mycorrhiza. These interactions enable many species to survive in different marginal lands to overcome the nitrogen-and/or phosphorus deficient environment and can potentially reduce the chemical fertilizers used in agriculture which gives them an economic, social and environmental importance. The formation and the development of these structures require the mediation of specific gene products among which the transcription factors play a key role...
February 15, 2018: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/29448178/modification-of-the-association-between-antipsychotic-treatment-response-and-childhood-adversity-by-mmp9-gene-variants-in-a-first-episode-schizophrenia-cohort
#10
Nathaniel McGregor, Nicole Thompson, Kevin Sean O'Connell, Robin Emsley, Lize van der Merwe, Louise Warnich
Antipsychotics remain the most effective, and wide used option for ameliorating the symptoms of schizophrenia. However, inter-individual differences in treatment outcome are vast and suggest a role for genetic and environmental factors in affording favourable outcomes. A notable epigenetic relationship which has gained considerable traction in recent literature is the way in which the severity of childhood trauma can modify associations seen between genetic variation and antipsychotic treatment response. A potential mechanism of action which may facilitate this relationship is synaptic plasticity...
February 7, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29446800/biology-of-vibrio-cholera-editorial-overview
#11
EDITORIAL
Felipe Cava
In this monographic issue, we have the pleasure to present contributions from six of the leading laboratories at the forefront of Vibrio cholerae genetics, ecology and evolution, together with a brief tribute by Diego Romero to Doctor Jaime Ferrán y Clua, a pioneering Spanish bacteriologist who developed the first vaccine against this pathogen. V. cholerae is a free-living aquatic bacterium that interacts with and infects a variety of organisms. In humans it causes cholera, the deadly diarrhoea that was responsible for millions of deaths during seven pandemics since 1817, and still thousands every year...
September 2017: International Microbiology: the Official Journal of the Spanish Society for Microbiology
https://www.readbyqxmd.com/read/29444258/modeling-the-influence-of-seasonal-differences-in-the-hpa-axis-on-synchronization-of-the-circadian-clock-and-cell-cycle
#12
Kamau Pierre, Rohit T Rao, Clara Hartmanshenn, Ioannis P Androulakis
Synchronization of biological functions to environmental signals enables organisms to anticipate and appropriately respond to daily external fluctuations and is critical to the maintenance of homeostasis. Misalignment of circadian rhythms with environmental cues is associated with adverse health outcomes. Cortisol, the downstream effector of hypothalamic-pituitary-adrenal (HPA) activity, facilitates synchronization of peripheral biological processes to the environment. Cortisol levels exhibit substantial seasonal rhythmicity, with peak levels occurring during the short-photoperiod winter months and reduced levels occurring in the long-photoperiod summer season...
February 12, 2018: Endocrinology
https://www.readbyqxmd.com/read/29444152/the-interaction-between-cannabis-use-and-the-val158met-polymorphism-of-the-comt-gene-in-psychosis-a-transdiagnostic-meta-analysis
#13
Thomas Stephanus Johannes Vaessen, Lea de Jong, Annika Theresia Schäfer, Thomas Damen, Aniek Uittenboogaard, Pauline Krolinski, Chinyere Vicky Nwosu, Florentina Maria Egidius Pinckaers, Iris Leah Marije Rotee, Antonius Petrus Wilhelmus Smeets, Ayşegül Ermiş, James L Kennedy, Dorien H Nieman, Arun Tiwari, Jim van Os, Marjan Drukker
BACKGROUND: Neither environmental nor genetic factors are sufficient to predict the transdiagnostic expression of psychosis. Therefore, analysis of gene-environment interactions may be productive. OBJECTIVE: A meta-analysis was performed using papers investigating the interaction between cannabis use and catechol-O-methyl transferase (COMT) polymorphism Val158Met (COMTVal158Met). DATA SOURCES: PubMed, Embase, PsychInfo. STUDY ELIGIBILITY CRITERIA: All observational studies assessing the interaction between COMTVal158Met and cannabis with any psychosis or psychotic symptoms measure as an outcome...
2018: PloS One
https://www.readbyqxmd.com/read/29442806/hetero-functionalized-gold-nanoparticles-to-silence-au-rich-element-containing-mrnas-in-rage-expressing-inflammatory-cells-preparation-characterization-and-in-vitro-evaluation
#14
Gokila Devi Mathialagan, Narkunaraja Shanmugam
Diabetes, a chronic metabolic disorder associated with significantly accelerated rates of inflammation. Gold nanoparticle plays a crucial role in biomedical applications. We described the development of hetero-functionalized gold nanoparticles (hfAuNPs) for targeted selective gene silencing by RNAi interference. This hfAuNPs was developed by parallelly conjugating biotinylated ARE-siRNA (siRNA to Adenosine Uridine-rich elements) and biotinylated RAGE interacting-peptide (RIP) to streptavidin coated gold nanoparticles (aAuNPs) thus forms a complex that provides biocompatibility and functionality in a physiological environment...
May 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29442488/biological-properties-and-pathogenicity-factors-of-helicobacter-pylori
#15
Guzel S Isaeva, Sharmila Fagoonee
The unexpected discovery of Helicobacter pylori (H. pylori) has revolutionised the history of microbiology as well as of gastroenterology in the last 30 years, with an invaluable benefit for millions of persons worldwide. The confirmation that this Gram-negative spiral bacterium could live in the stomach has rendered out-of-date the concept of inhospitality of micro-organisms in the gastric environment, after a long history of unheard reports on the presence of spiral bacteria in the stomach. The pathogenicity of H...
February 14, 2018: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/29441119/diagnosis-monitoring-and-prevention-of-exposure-related-non-communicable-diseases-in-the-living-and-working-environment-dimopex-project-is-designed-to-determine-the-impacts-of-environmental-exposure-on-human-health
#16
REVIEW
Lygia Therese Budnik, Balazs Adam, Maria Albin, Barbara Banelli, Xaver Baur, Fiorella Belpoggi, Claudia Bolognesi, Karin Broberg, Per Gustavsson, Thomas Göen, Axel Fischer, Dorota Jarosinska, Fabiana Manservisi, Richard O'Kennedy, Johan Øvrevik, Elizabet Paunovic, Beate Ritz, Paul T J Scheepers, Vivi Schlünssen, Heidi Schwarzenbach, Per E Schwarze, Orla Sheils, Torben Sigsgaard, Karel Van Damme, Ludwine Casteleyn
The WHO has ranked environmental hazardous exposures in the living and working environment among the top risk factors for chronic disease mortality. Worldwide, about 40 million people die each year from noncommunicable diseases (NCDs) including cancer, diabetes, and chronic cardiovascular, neurological and lung diseases. The exposure to ambient pollution in the living and working environment is exacerbated by individual susceptibilities and lifestyle-driven factors to produce complex and complicated NCD etiologies...
2018: Journal of Occupational Medicine and Toxicology
https://www.readbyqxmd.com/read/29439838/evolutionary-mechanisms-shaping-the-maintenance-of-antibiotic-resistance
#17
REVIEW
Paulo Durão, Roberto Balbontín, Isabel Gordo
Antibiotics target essential cellular functions but bacteria can become resistant by acquiring either exogenous resistance genes or chromosomal mutations. Resistance mutations typically occur in genes encoding essential functions; these mutations are therefore generally detrimental in the absence of drugs. However, bacteria can reduce this handicap by acquiring additional mutations, known as compensatory mutations. Genetic interactions (epistasis) either with the background or between resistances (in multiresistant bacteria) dramatically affect the fitness cost of antibiotic resistance and its compensation, therefore shaping dissemination of antibiotic resistance mutations...
February 10, 2018: Trends in Microbiology
https://www.readbyqxmd.com/read/29439620/acute-drug-effects-on-the-human-placental-tissue-the-development-of-a-placental-murine-xenograft-model
#18
Magali Verheecke, Els Hermans, Sandra Tuyaerts, Erika Souche, Rita Van Bree, Godelieve Verbist, Tina Everaert, Jeroen Van Houdt, Kristel Van Calsteren, Frederic Amant
OBJECTIVE: A pilot study was conducted to establish a human placental xenograft, which could serve as a model to evaluate the effect of toxic exposures during pregnancy. STUDY DESIGN: The protocol consisted of engraftment of third-trimester human placental tissue in immunocompromised mice, after induction of a pseudo-pregnancy state by ovariectomy and progesterone supplementation. To validate the model, the placental tissue before and after engraftment was examined by immunohistochemistry, fluorescence-activated cell sorting (FACS), single-nucleotide polymorphism (SNP) genotyping, and whole transcriptome sequencing (WTSS)...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29439211/comparative-analysis-of-arabidopsis-ecotypes-reveals-a-role-for-brassinosteroids-in-root-hydrotropism
#19
Rui Miao, Meng Wang, Wei Yuan, Yan Ren, Ying Li, Na Zhang, Jianhua Zhang, Herbert J Kronzucker, Weifeng Xu
Plant root responds to soil moisture gradients through hydrotropism and remodels root growth orientation chasing soil water, a process regarded as plant acclimation to a changing soil environment. Mechanisms underlying the root hydrotropic response, however, remain poorly understood. Here, hydrotropism was examined in 31 Arabidopsis ecotypes collected from different parts of the world and grown along moisture gradients in a specially designed soil-simulation system. More detailed comparative transcriptomic, ionomic profiling, and physiological analyses were carried out on three wild types, Ws (strongly hydrotropic), Col-0 (moderately hydrotropic), and C24 (weakly hydrotropic), and also in mutant lines showing disruptions in the root hydrotropic response...
February 8, 2018: Plant Physiology
https://www.readbyqxmd.com/read/29436922/breast-cancer-family-history-and-allele-specific-dna-methylation-in-the-legacy-girls-study
#20
Hui-Chen Wu, Catherine Do, Irene L Andrulis, Esther M John, Mary B Daly, Saundra S Buys, Wendy K Chung, Julia A Knight, Angela R Bradbury, Theresa H M Keegan, Lisa Schwartz, Izabela Krupska, Rachel L Miller, Regina M Santella, Benjamin Tycko, Mary Beth Terry
Family history, a well-established risk factor for breast cancer, can have both genetic and environmental contributions. Shared environment in families as well as epigenetic changes that also may be influenced by shared genetics and environment may also explain familial clustering of cancers. Epigenetic regulation, such as DNA methylation, can change the activity of a DNA segment without a change in the sequence; environmental exposures experienced across the life course can induce such changes. However, genetic-epigenetic interactions, detected as methylation quantitative trait loci (mQTLs; a...
February 13, 2018: Epigenetics: Official Journal of the DNA Methylation Society
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