keyword
MENU ▼
Read by QxMD icon Read
search

dti spinal

keyword
https://www.readbyqxmd.com/read/29227148/structural-abnormalities-and-altered-regional-brain-activity-in-multiple-sclerosis-with-simple-spinal-cord-involvement
#1
Ping Yin, Yi Liu, Hua Xiong, Yongliang Han, Shambhu Kumar Sah, Chun Zeng, Jingjie Wang, Yongmei Li
OBJECTIVE: To assess the changes of the structural and functional abnormalities in multiple sclerosis with simple spinal cord involvement (MS-SSCI) by using resting-state functional magnetic resonance imaging (RS-fMRI), voxel based morphology (VBM) and diffusion tensor tractography. METHODS: The amplitude of low-frequency fluctuation (ALFF) of 22 patients with MS-SSCI and 22 healthy controls (HCs) matched for age, gender and education were compared by using RS-fMRI...
December 11, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29175489/diffusion-tensor-imaging-identifies-presymptomatic-axonal-degeneration-in-the-spinal-cord-of-als-mice
#2
Rodolfo G Gatto, Weiguo Li, Richard L Magin
Extensive pathological evidence indicates that axonal degeneration represents an early and critical event in amyotrophic lateral sclerosis (ALS). Unfortunately, few MRI studies have focused in the early detection of white matter (WM) alterations in the spinal cord region. To unveil these WM changes, we performed high resolution diffusion tensor imaging (DTI) and correlated the results with histological analysis of adjacent slices taken from the spinal cords of presymptomatic mice. The DTI studies demonstrated a significant reduction in fractional anisotropy (FA) as well as axial diffusivities (AD) and an increase in radial diffusivity (RD), predominantly at lower segments of the spinal cord...
November 23, 2017: Brain Research
https://www.readbyqxmd.com/read/29174922/detecting-spinal-pyramidal-tract-of-amyotrophic-lateral-sclerosis-patients-with-diffusion-tensor-tractography
#3
Yusuke Fukui, Nozomi Hishikawa, Kota Sato, Yumiko Nakano, Ryuta Morihara, Jingwei Shang, Mami Takemoto, Yasuyuki Ohta, Toru Yamashita, Koji Abe
The objective of this study was to determine alteration of corticospinal tract in patients with amyotrophic lateral sclerosis (ALS) using diffusion tensor tractograhy (DTT) focusing on the cervical spinal cord (C5) and transcranial magnetic stimulation (TMS). We recruited 38 ALS, 6 spinal and bulbar muscular atrophy (SBMA), 7 spastic paraplegia (SP) patients, and 8 age-matched normal controls, and then ALS were divided into two subgroups according to their clinical type: 28 ALS-limb and 10 ALS-bulbar. DTT was performed using the diffusion tensor image (DTI) track module to reconstruct two fiber tracts via C5...
November 21, 2017: Neuroscience Research
https://www.readbyqxmd.com/read/29154897/identification-of-ghost-artifact-using-texture-analysis-in-pediatric-spinal-cord-diffusion-tensor-images
#4
Mahdi Alizadeh, Chris J Conklin, Devon M Middleton, Pallav Shah, Sona Saksena, Laura Krisa, Jürgen Finsterbusch, Scott H Faro, M J Mulcahey, Feroze B Mohamed
PURPOSE: Ghost artifacts are a major contributor to degradation of spinal cord diffusion tensor images. A multi-stage post-processing pipeline was designed, implemented and validated to automatically remove ghost artifacts arising from reduced field of view diffusion tensor imaging (DTI) of the pediatric spinal cord. METHOD: A total of 12 pediatric subjects including 7 healthy subjects (mean age=11.34years) with no evidence of spinal cord injury or pathology and 5 patients (mean age=10...
November 15, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29154896/diffusion-tensor-imaging-of-spinal-cord-parenchyma-lesion-in-rat-with-chronic-spinal-cord-injury
#5
Can Zhao, Jia-Sheng Rao, Xiao-Jiao Pei, Jian-Feng Lei, Zhan-Jing Wang, Wen Zhao, Rui-Han Wei, Zhao-Yang Yang, Xiao-Guang Li
PURPOSE: Adequate evaluation of spinal cord parenchyma and accurate identification of injury range are considered two premises for the research and treatment of chronic spinal cord injury (SCI). Diffusion tensor imaging (DTI) provides information about water diffusion in spinal cord, and thus makes it possible to realize these premises. METHOD: In this study, we conducted magnetic resonance imaging (MRI) for Wistar rats 84days after spinal cord contusion. DTI metrics including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) from different positions of the injured cord were collected, analyzed, and compared with the histological results and locomotor outcomes...
November 14, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29111113/understanding-the-relationship-between-brain-and-upper-limb-function-in-children-with-unilateral-motor-impairments-a-multimodal-approach
#6
Maya Weinstein, Dido Green, Julian Rudisch, Ingar M Zielinski, Marta Benthem-Muñiz, Marijtje L A Jongsma, Verity McClelland, Bert Steenbergen, Shelly Shiran, Dafna Ben Bashat, Gareth J Barker
Atypical brain development and early brain injury have profound and long lasting impact on the development, skill acquisition, and subsequent independence of a child. Heterogeneity is present at the brain level and at the motor level; particularly with respect to phenomena of bilateral activation and mirrored movements (MMs). In this multiple case study we consider the feasibility of using several modalities to explore the relationship between brain structure and/or activity and hand function: Electroencephalography (EEG), both structural and functional Magnetic Resonance Imaging (sMRI, fMRI), diffusion tensor imaging (DTI), transcranial magnetic stimulation (TMS), Electromyography (EMG) and hand function assessments...
October 12, 2017: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29073810/reduced-field-of-view-diffusion-tensor-imaging-and-fiber-tractography-of-the-pediatric-cervical-and-thoracic-spinal-cord-injury
#7
Mahdi Alizadeh, Joshua Fisher, Sona Saksena, Yusra Sultan, Christopher Conklin, Devon Middleton, Jürgen Finsterbusch, Laura Krisa, Adam Flanders, Scott Faro, M J Mulcahey, Feroze Mohamed
The purpose of this study is to assess the utility and effectiveness of diffusion tensor imaging (DTI) and diffusion tensor tractography (DTT) of the entire pediatric cervical and thoracic spinal cord towards discrimination of typically developing (TD) controls and subjects with spinal cord injury (SCI). A total of 43 pediatric subjects including 23 TD subjects ranging in age from 6-16 years old and 20 subjects with SCI ranging in age from 7-16 years old were recruited and scanned using a 3.0T MR scanner. Reduced field of view (FOV) diffusion tensor images were acquired axially to cover the entire spinal cord across two slabs...
October 26, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29041865/imaging-outcome-measures-for-progressive-multiple-sclerosis-trials
#8
Marcello Moccia, Nicola de Stefano, Frederik Barkhof
Imaging markers that are reliable, reproducible and sensitive to neurodegenerative changes in progressive multiple sclerosis (MS) can enhance the development of new medications with a neuroprotective mode-of-action. Accordingly, in recent years, a considerable number of imaging biomarkers have been included in phase 2 and 3 clinical trials in primary and secondary progressive MS. Brain lesion count and volume are markers of inflammation and demyelination and are important outcomes even in progressive MS trials...
October 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28991695/monozygotic-twins-with-a-new-compound-heterozygous-spg11-mutation-and-different-disease-expression
#9
Christiane Schneider-Gold, Gabriele Dekomien, Martin Regensburger, Ruth Schneider, Nadine Trampe, Christos Krogias, Carsten Lukas, Barbara Bellenberg
BACKGROUND: A pair of monozygotic 22-year-old twins with complicated hereditary spastic paraplegia caused by a novel SPG11 mutation is described. METHODS: Genetic testing and thorough clinical examination, magnetic resonance imaging (MRI) and MR-spectroscopy were performed. RESULTS: The twins were compound heterozygous for a known frameshift as well as a novel splice site mutation in the SPG11 gene. Clinically the patients showed a similar spectrum of symptoms but different disease presentation...
October 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28974151/the-relationship-between-lesion-severity-characterized-by-diffusion-tensor-imaging-and-motor-function-in-chronic-canine-spinal-cord-injury
#10
Melissa J Lewis, Pew-Thian Yap, Susan McCullough, Natasha J Olby
Lesion heterogeneity among chronically paralyzed dogs after acute, complete thoracolumbar spinal cord injury (TLSCI) is poorly described. We hypothesized that lesion severity quantified by diffusion tensor imaging (DTI) is associated with hindlimb motor function. Our objectives were to quantify lesion severity with fractional anisotropy (FA), mean diffusivity (MD), and tractography and investigate associations with motor function. Twenty-two dogs with complete TLSCI in the chronic stage were enrolled and compared with six control dogs...
November 17, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28948090/predictors-of-symptomatic-myelopathy-in-degenerative-cervical-spinal-cord-compression
#11
Zdenek Kadanka, Blanka Adamova, Milos Kerkovsky, Zdenek Kadanka, Ladislav Dusek, Barbora Jurova, Eva Vlckova, Josef Bednarik
OBJECTIVES: To update a previously established list of predictors for neurological cervical cord dysfunction in nonmyelopathic degenerative cervical cord compression (NMDCCC). MATERIAL AND METHODS: A prospective observational follow-up study was performed in a cohort of 112 consecutive NMDCCC subjects (55 women and 57 men; median age 59 years, range 40-79 years), either asymptomatic (40 subjects) or presenting with cervical radiculopathy or cervical pain (72 subjects), who had completed a follow-up of at least 2 years (median duration 3 years)...
September 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28937274/visualization-of-the-lumbar-nerve-using-reduced-field-of-view-diffusion-tensor-imaging
#12
Yawara Eguchi, Hirohito Kanamoto, Sumihisa Orita, Kazuhide Inage, Kazuki Fujimoto, Yasuhiro Shiga, Koki Abe, Masahiro Inoue, Hideyuki Kinoshita, Koji Matsumoto, Yoshitada Masuda, Masao Koda, Yasuchika Aoki, Yasuhiro Oikawa, Kazuhisa Takahashi, Seiji Ohtori, Takeo Furuya, Atsuya Watanabe
OBJECTIVE: We investigated high resolution diffusion tensor imaging (DTI) of lumbar nerves with reduced field-of-view (rFOV) using 3-Tesla MRI. METHODS: DTI measured with rFOV was compared with conventional FOV (cFOV) 3.0 T MRI in 5 healthy volunteers and 10 patients with degenerative lumbar disorders. The intracanal, foramina, and extraforamina of the L5 nerve were established as the regions-of-interest (ROI) and fractional anisotropy (FA) values and apparent diffusion coefficient (ADC) values were measured...
September 13, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28926131/region-specific-impairment-of-the-cervical-spinal-cord-sc-in-amyotrophic-lateral-sclerosis-a-preliminary-study-using-sc-templates-and-quantitative-mri-diffusion-tensor-imaging-inhomogeneous-magnetization-transfer
#13
Henitsoa Rasoanandrianina, Aude-Marie Grapperon, Manuel Taso, Olivier M Girard, Guillaume Duhamel, Maxime Guye, Jean-Philippe Ranjeva, Shahram Attarian, Annie Verschueren, Virginie Callot
In this preliminary study, our objective was to investigate the potential of high-resolution anatomical imaging, diffusion tensor imaging (DTI) and conventional/inhomogeneous magnetization transfer imaging [magnetization transfer (MT)/inhomogeneous magnetization transfer (ihMT)] at 3 T, analyzed with template-extracted regions of interest, to measure the atrophy and structural changes of white (WM) and gray (GM) matter spinal cord (SC) occurring in patients with amyotrophic lateral sclerosis (ALS). Ten patients with ALS and 20 age-matched healthy controls were recruited...
September 19, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28904988/neurite-dispersion-a-new-marker-of-multiple-sclerosis-spinal-cord-pathology
#14
Francesco Grussu, Torben Schneider, Carmen Tur, Richard L Yates, Mohamed Tachrount, Andrada Ianuş, Marios C Yiannakas, Jia Newcombe, Hui Zhang, Daniel C Alexander, Gabriele C DeLuca, Claudia A M Gandini Wheeler-Kingshott
OBJECTIVE: Conventional magnetic resonance imaging (MRI) of the multiple sclerosis spinal cord is limited by low specificity regarding the underlying pathological processes, and new MRI metrics assessing microscopic damage are required. We aim to show for the first time that neurite orientation dispersion (i.e., variability in axon/dendrite orientations) is a new biomarker that uncovers previously undetected layers of complexity of multiple sclerosis spinal cord pathology. Also, we validate against histology a clinically viable MRI technique for dispersion measurement (neurite orientation dispersion and density imaging, NODDI), to demonstrate the strong potential of the new marker...
September 2017: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/28887076/microstructural-mechanisms-of-analgesia-in-percutaneous-cervical-cordotomy-revealed-by-diffusion-tensor-imaging
#15
Stephen S Gebarski, Srinivas Chiravuri, Bradley R Foerster, Parag G Patil
The purpose of this study is to demonstrate the potential of diffusion tensor imaging (DTI) to reveal structural mechanisms underlying spinal ablative procedures, including percutaneous radiofrequency cordotomy (PRFC). PRFC is a surgical procedure that produces analgesia through focal ablation of the lateral spinothalamic tract (STT), thereby interrupting the flow of pain information from the periphery to the brain. To date, studies regarding mechanisms of analgesia after PRFC have been limited to postmortem cadaveric dissection and histology...
November 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28879883/the-role-of-diffusion-tensor-imaging-in-spinal-pathology-a-review
#16
REVIEW
Dan C Li, James G Malcolm, Rima S Rindler, Griffin R Baum, Avinash Rao, Shekar N Khurpad, Faiz U Ahmad
Diffusion tensor imaging (DTI) allows for noninvasive, in vivo visualization of white matter fiber tracts in the central nervous system by measuring the diffusion of water molecules. It provides both quantitative and qualitative (i.e., tractography) means to describe a region-of-interest. While protocols for the use of DTI are better established in the brain, the efficacy and potential applications of DTI in spinal cord pathology are less understood. In this review, we examine the current literature regarding the use of DTI in the spinal cord pathology, and in particular its diagnostic and prognostic value in traumatic injury, spinal tumors, cervical myelopathies, amyotrophic lateral sclerosis, and multiple sclerosis...
September 2017: Neurology India
https://www.readbyqxmd.com/read/28869104/diffusion-tensor-imaging-of-the-spinal-cord-clinical-value-investigational-applications-and-technical-limitations
#17
REVIEW
Aaron M Rutman, Daniel J Peterson, Wendy A Cohen, Mahmud Mossa-Basha
Although diffusion-weighted imaging (DWI) has become a mainstay in modern brain imaging, it remains less utilized in the evaluation of the spinal cord. Many studies have shown promise in using DWI and diffusion-tensor imaging (DTI) for evaluation of the spinal cord; however, application has been stalled by technical obstacles and artifacts, and questions remain regarding its clinical utility on an individual examination level. This review discusses the background, concepts, and technical aspects of DWI and DTI, specifically for imaging of the spinal cord...
July 29, 2017: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/28830310/classification-of-diffusion-tensor-metrics-for-the-diagnosis-of-a-myelopathic-cord-using-machine-learning
#18
Shuqiang Wang, Yong Hu, Yanyan Shen, Hanxiong Li
In this study, we propose an automated framework that combines diffusion tensor imaging (DTI) metrics with machine learning algorithms to accurately classify control groups and groups with cervical spondylotic myelopathy (CSM) in the spinal cord. The comparison between selected voxel-based classification and mean value-based classification were performed. A support vector machine (SVM) classifier using a selected voxel-based dataset produced an accuracy of 95.73%, sensitivity of 93.41% and specificity of 98...
July 16, 2017: International Journal of Neural Systems
https://www.readbyqxmd.com/read/28818826/test-retest-and-interreader-reproducibility-of-semiautomated-atlas-based-analysis-of-diffusion-tensor-imaging-data-in-acute-cervical-spine-trauma-in-adult-patients
#19
D J Peterson, A M Rutman, D S Hippe, J G Jarvik, F H Chokshi, M R Reyes, C H Bombardier, M Mossa-Basha
BACKGROUND AND PURPOSE: DTI is a tool for microstructural spinal cord injury evaluation. This study evaluated the reproducibility of a semiautomated segmentation algorithm of spinal cord DTI. MATERIALS AND METHODS: Forty-two consecutive patients undergoing acute trauma cervical spine MR imaging underwent 2 axial DTI scans in addition to their clinical scan. The datasets were put through a semiautomated probabilistic segmentation algorithm that selected white matter, gray matter, and 24 individual white matter tracts...
August 17, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28762382/spontaneous-acute-and-chronic-spinal-cord-injuries-in-paraplegic-dogs-a-comparative-study-of-in-vivo-diffusion-tensor-imaging
#20
A Wang-Leandro, M K Hobert, N Alisauskaite, P Dziallas, K Rohn, V M Stein, A Tipold
STUDY DESIGN: Prospective observational-analytical study. OBJECTIVES: Description of diffusion tensor imaging (DTI) metrics obtained from the spinal cord (SC) of dogs with severe acute or chronic spontaneous, non-experimentally induced spinal cord injury (SCI) and correlation of DTI values with lesion extent of SCI measured in T2-weighted (T2W) magnetic resonance imaging sequences. SETTING: Hannover, Germany. METHODS: Forty-seven paraplegic dogs, 32 with acute and 15 with chronic SCI, and 6 disease controls were included...
August 1, 2017: Spinal Cord
keyword
keyword
73883
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"