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https://www.readbyqxmd.com/read/29041865/imaging-outcome-measures-for-progressive-multiple-sclerosis-trials
#1
Marcello Moccia, Nicola de Stefano, Frederik Barkhof
Imaging markers that are reliable, reproducible and sensitive to neurodegenerative changes in progressive multiple sclerosis (MS) can enhance the development of new medications with a neuroprotective mode-of-action. Accordingly, in recent years, a considerable number of imaging biomarkers have been included in phase 2 and 3 clinical trials in primary and secondary progressive MS. Brain lesion count and volume are markers of inflammation and demyelination and are important outcomes even in progressive MS trials...
October 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28991695/monozygotic-twins-with-a-new-compound-heterozygous-spg11-mutation-and-different-disease-expression
#2
Christiane Schneider-Gold, Gabriele Dekomien, Martin Regensburger, Ruth Schneider, Nadine Trampe, Christos Krogias, Carsten Lukas, Barbara Bellenberg
BACKGROUND: A pair of monozygotic 22-year-old twins with complicated hereditary spastic paraplegia caused by a novel SPG11 mutation is described. METHODS: Genetic testing and thorough clinical examination, magnetic resonance imaging (MRI) and MR-spectroscopy were performed. RESULTS: The twins were compound heterozygous for a known frameshift as well as a novel splice site mutation in the SPG11 gene. Clinically the patients showed a similar spectrum of symptoms but different disease presentation...
October 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28974151/the-relationship-between-lesion-severity-characterized-by-diffusion-tensor-imaging-and-motor-function-in-chronic-canine-spinal-cord-injury
#3
Melissa Lewis, Pew-Thian Yap, Susan McCullough, Natasha Olby
Lesion heterogeneity amongst chronically paralyzed dogs after acute, complete thoracolumbar spinal cord injury (TLSCI) is poorly described. We hypothesized that lesion severity quantified by Diffusion Tensor Imaging (DTI) is associated with hind limb motor function. Our objectives were to quantify lesion severity with fractional anisotropy (FA), mean diffusivity (MD) and tractography and investigate associations with motor function. Twenty-two dogs with complete TLSCI in the chronic stage were enrolled and compared to 6 control dogs...
October 3, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28948090/predictors-of-symptomatic-myelopathy-in-degenerative-cervical-spinal-cord-compression
#4
Zdenek Kadanka, Blanka Adamova, Milos Kerkovsky, Zdenek Kadanka, Ladislav Dusek, Barbora Jurova, Eva Vlckova, Josef Bednarik
OBJECTIVES: To update a previously established list of predictors for neurological cervical cord dysfunction in nonmyelopathic degenerative cervical cord compression (NMDCCC). MATERIAL AND METHODS: A prospective observational follow-up study was performed in a cohort of 112 consecutive NMDCCC subjects (55 women and 57 men; median age 59 years, range 40-79 years), either asymptomatic (40 subjects) or presenting with cervical radiculopathy or cervical pain (72 subjects), who had completed a follow-up of at least 2 years (median duration 3 years)...
September 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28937274/visualization-of-the-lumbar-nerve-using-reduced-field-of-view-diffusion-tensor-imaging
#5
Yawara Eguchi, Hirohito Kanamoto, Sumihisa Orita, Kazuhide Inage, Kazuki Fujimoto, Yasuhiro Shiga, Koki Abe, Masahiro Inoue, Hideyuki Kinoshita, Koji Matsumoto, Yoshitada Masuda, Masao Koda, Yasuchika Aoki, Yasuhiro Oikawa, Kazuhisa Takahashi, Seiji Ohtori, Takeo Furuya, Atsuya Watanabe
OBJECTIVE: We investigated high resolution diffusion tensor imaging (DTI) of lumbar nerves with reduced field-of-view (rFOV) using 3-Tesla MRI. METHODS: DTI measured with rFOV was compared with conventional FOV (cFOV) 3.0 T MRI in 5 healthy volunteers and 10 patients with degenerative lumbar disorders. The intracanal, foramina, and extraforamina of the L5 nerve were established as the regions-of-interest (ROI) and fractional anisotropy (FA) values and apparent diffusion coefficient (ADC) values were measured...
September 13, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28926131/region-specific-impairment-of-the-cervical-spinal-cord-sc-in-amyotrophic-lateral-sclerosis-a-preliminary-study-using-sc-templates-and-quantitative-mri-diffusion-tensor-imaging-inhomogeneous-magnetization-transfer
#6
Henitsoa Rasoanandrianina, Aude-Marie Grapperon, Manuel Taso, Olivier M Girard, Guillaume Duhamel, Maxime Guye, Jean-Philippe Ranjeva, Shahram Attarian, Annie Verschueren, Virginie Callot
In this preliminary study, our objective was to investigate the potential of high-resolution anatomical imaging, diffusion tensor imaging (DTI) and conventional/inhomogeneous magnetization transfer imaging [magnetization transfer (MT)/inhomogeneous magnetization transfer (ihMT)] at 3 T, analyzed with template-extracted regions of interest, to measure the atrophy and structural changes of white (WM) and gray (GM) matter spinal cord (SC) occurring in patients with amyotrophic lateral sclerosis (ALS). Ten patients with ALS and 20 age-matched healthy controls were recruited...
September 19, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28904988/neurite-dispersion-a-new-marker-of-multiple-sclerosis-spinal-cord-pathology
#7
Francesco Grussu, Torben Schneider, Carmen Tur, Richard L Yates, Mohamed Tachrount, Andrada Ianuş, Marios C Yiannakas, Jia Newcombe, Hui Zhang, Daniel C Alexander, Gabriele C DeLuca, Claudia A M Gandini Wheeler-Kingshott
OBJECTIVE: Conventional magnetic resonance imaging (MRI) of the multiple sclerosis spinal cord is limited by low specificity regarding the underlying pathological processes, and new MRI metrics assessing microscopic damage are required. We aim to show for the first time that neurite orientation dispersion (i.e., variability in axon/dendrite orientations) is a new biomarker that uncovers previously undetected layers of complexity of multiple sclerosis spinal cord pathology. Also, we validate against histology a clinically viable MRI technique for dispersion measurement (neurite orientation dispersion and density imaging, NODDI), to demonstrate the strong potential of the new marker...
September 2017: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/28887076/microstructural-mechanisms-of-analgesia-in-percutaneous-cervical-cordotomy-revealed-by-diffusion-tensor-imaging
#8
Stephen S Gebarski, Srinivas Chiravuri, Bradley R Foerster, Parag G Patil
The purpose of this study is to demonstrate the potential of diffusion tensor imaging (DTI) to reveal structural mechanisms underlying spinal ablative procedures, including percutaneous radiofrequency cordotomy (PRFC). PRFC is a surgical procedure that produces analgesia through focal ablation of the lateral spinothalamic tract (STT), thereby interrupting the flow of pain information from the periphery to the brain. To date, studies regarding mechanisms of analgesia after PRFC have been limited to postmortem cadaveric dissection and histology...
November 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28879883/the-role-of-diffusion-tensor-imaging-in-spinal-pathology-a-review
#9
REVIEW
Dan C Li, James G Malcolm, Rima S Rindler, Griffin R Baum, Avinash Rao, Shekar N Khurpad, Faiz U Ahmad
Diffusion tensor imaging (DTI) allows for noninvasive, in vivo visualization of white matter fiber tracts in the central nervous system by measuring the diffusion of water molecules. It provides both quantitative and qualitative (i.e., tractography) means to describe a region-of-interest. While protocols for the use of DTI are better established in the brain, the efficacy and potential applications of DTI in spinal cord pathology are less understood. In this review, we examine the current literature regarding the use of DTI in the spinal cord pathology, and in particular its diagnostic and prognostic value in traumatic injury, spinal tumors, cervical myelopathies, amyotrophic lateral sclerosis, and multiple sclerosis...
September 2017: Neurology India
https://www.readbyqxmd.com/read/28869104/diffusion-tensor-imaging-of-the-spinal-cord-clinical-value-investigational-applications-and-technical-limitations
#10
REVIEW
Aaron M Rutman, Daniel J Peterson, Wendy A Cohen, Mahmud Mossa-Basha
Although diffusion-weighted imaging (DWI) has become a mainstay in modern brain imaging, it remains less utilized in the evaluation of the spinal cord. Many studies have shown promise in using DWI and diffusion-tensor imaging (DTI) for evaluation of the spinal cord; however, application has been stalled by technical obstacles and artifacts, and questions remain regarding its clinical utility on an individual examination level. This review discusses the background, concepts, and technical aspects of DWI and DTI, specifically for imaging of the spinal cord...
July 29, 2017: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/28830310/classification-of-diffusion-tensor-metrics-for-the-diagnosis-of-a-myelopathic-cord-using-machine-learning
#11
Shuqiang Wang, Yong Hu, Yanyan Shen, Hanxiong Li
In this study, we propose an automated framework that combines diffusion tensor imaging (DTI) metrics with machine learning algorithms to accurately classify control groups and groups with cervical spondylotic myelopathy (CSM) in the spinal cord. The comparison between selected voxel-based classification and mean value-based classification were performed. A support vector machine (SVM) classifier using a selected voxel-based dataset produced an accuracy of 95.73%, sensitivity of 93.41% and specificity of 98...
July 16, 2017: International Journal of Neural Systems
https://www.readbyqxmd.com/read/28818826/test-retest-and-interreader-reproducibility-of-semiautomated-atlas-based-analysis-of-diffusion-tensor-imaging-data-in-acute-cervical-spine-trauma-in-adult-patients
#12
D J Peterson, A M Rutman, D S Hippe, J G Jarvik, F H Chokshi, M R Reyes, C H Bombardier, M Mossa-Basha
BACKGROUND AND PURPOSE: DTI is a tool for microstructural spinal cord injury evaluation. This study evaluated the reproducibility of a semiautomated segmentation algorithm of spinal cord DTI. MATERIALS AND METHODS: Forty-two consecutive patients undergoing acute trauma cervical spine MR imaging underwent 2 axial DTI scans in addition to their clinical scan. The datasets were put through a semiautomated probabilistic segmentation algorithm that selected white matter, gray matter, and 24 individual white matter tracts...
August 17, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28762382/spontaneous-acute-and-chronic-spinal-cord-injuries-in-paraplegic-dogs-a-comparative-study-of-in-vivo-diffusion-tensor-imaging
#13
A Wang-Leandro, M K Hobert, N Alisauskaite, P Dziallas, K Rohn, V M Stein, A Tipold
STUDY DESIGN: Prospective observational-analytical study. OBJECTIVES: Description of diffusion tensor imaging (DTI) metrics obtained from the spinal cord (SC) of dogs with severe acute or chronic spontaneous, non-experimentally induced spinal cord injury (SCI) and correlation of DTI values with lesion extent of SCI measured in T2-weighted (T2W) magnetic resonance imaging sequences. SETTING: Hannover, Germany. METHODS: Forty-seven paraplegic dogs, 32 with acute and 15 with chronic SCI, and 6 disease controls were included...
August 1, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28744730/relationships-between-the-integrity-and-function-of-lumbar-nerve-roots-as-assessed-by-diffusion-tensor-imaging-and-neurophysiology
#14
S Y Chiou, P J Hellyer, D J Sharp, R D Newbould, M C Patel, P H Strutton
PURPOSE: Diffusion tensor imaging (DTI) has shown promise in the measurement of peripheral nerve integrity, although the optimal way to apply the technique for the study of lumbar spinal nerves is unclear. The aims of this study are to use an improved DTI acquisition to investigate lumbar nerve root integrity and correlate this with functional measures using neurophysiology. METHODS: Twenty healthy volunteers underwent 3 T DTI of the L5/S1 area. Regions of interest were applied to L5 and S1 nerve roots, and DTI metrics (fractional anisotropy, mean, axial and radial diffusivity) were derived...
July 25, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28714054/the-functional-relevance-of-diffusion-tensor-imaging-in-comparison-to-conventional-mri-in-patients-with-cervical-compressive-myelopathy
#15
Young-Mi Yang, Woo-Kyoung Yoo, Je Hyun Yoo, Yoon Hae Kwak, Jae-Keun Oh, Ji-Sun Song, Seok Woo Kim
OBJECTIVE: To determine the functional relevance of diffusion tensor imaging (DTI) metrics and conventional MRI (signal intensity change in T2, compression ratio) by measuring the correlation of these parameters with clinical outcome measured by the modified Japanese Orthopedic Association (mJOA) score. MATERIALS AND METHODS: A total of 20 cervical myelopathy (CM) patients participated in this prospective cohort study. The severities of CM were assessed using the mJOA score...
July 17, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28711563/application-of-neurite-orientation-dispersion-and-density-imaging-or-diffusion-tensor-imaging-to-quantify-the-severity-of-cervical-spondylotic-myelopathy-and-to-assess-postoperative-neurologic-recovery
#16
Genki Okita, Tetsuro Ohba, Tomohiro Takamura, Shigeto Ebata, Ryo Ueda, Hiroshi Onishi, Hirotaka Haro, Masaaki Hori
BACKGROUND CONTEXT: Surgical outcome and the severity of cervical spondylotic myelopathy (CSM) are unpredictable and cannot be estimated by conventional anatomical magnetic resonance imaging (MRI). The utility of diffusion tensor imaging (DTI) to quantify the severity of CSM and to assess postoperative neurologic recovery has been investigated. However, whether conventional DTI should be applied in a clinical setting remains controversial. Neurite orientation dispersion and density imaging (NODDI) is a recently introduced model-based diffusion-weighted MRI technique that quantifies specific microstructural features related directly to neuronal morphology...
July 12, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28703331/high-resolution-diffusion-tensor-imaging-in-cervical-spondylotic-myelopathy-a-preliminary-follow-up-study
#17
Li Guan, Xiaolong Chen, Yong Hai, Xiaodong Ma, Le He, Guangzhi Wang, Chun Yuan, Hua Guo
Diffusion imaging is a promising technique as it can provide microstructural tissue information and thus potentially show viable changes in spinal cord. However, the traditional single-shot imaging method is limited as a result of various image artifacts. In order to improve measurement accuracy, we used a newly developed, multi-shot, high-resolution, diffusion tensor imaging (DTI) method to investigate diffusion metric changes and compare them with T2 -weighted (T2W) images before and after decompressive surgery for cervical spondylotic myelopathy (CSM)...
October 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28669912/the-efficiency-of-retrospective-artifact-correction-methods-in-improving-the-statistical-power-of-between-group-differences-in-spinal-cord-dti
#18
Gergely David, Patrick Freund, Siawoosh Mohammadi
Diffusion tensor imaging (DTI) is a promising approach for investigating the white matter microstructure of the spinal cord. However, it suffers from severe susceptibility, physiological, and instrumental artifacts present in the cord. Retrospective correction techniques are popular approaches to reduce these artifacts, because they are widely applicable and do not increase scan time. In this paper, we present a novel outlier rejection approach (reliability masking) which is designed to supplement existing correction approaches by excluding irreversibly corrupted and thus unreliable data points from the DTI index maps...
June 29, 2017: NeuroImage
https://www.readbyqxmd.com/read/28631276/comparison-of-two-different-analysis-approaches-for-dti-free-water-corrected-and-uncorrected-maps-in-the-study-of-white-matter-microstructural-integrity-in-individuals-with-depression
#19
Maurizio Bergamino, Rayus Kuplicki, Teresa A Victor, Yoon-Hee Cha, Martin P Paulus
Diffusion tensor imaging (DTI) has often been used to examine white matter (WM) tract abnormalities in depressed subjects, but these studies have yielded inconsistent results, probably, due to gender composition or small sample size. In this study, we applied different analysis pipelines to a relatively large sample of individuals with depression to determine whether previous findings in depression can be replicated with these pipelines. We used a "standard" DTI algorithm and maps computed through a free-water (FW) corrected DTI...
September 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28623403/diffusion-tensor-imaging-can-predict-surgical-outcomes-of-patients-with-cervical-compression-myelopathy
#20
Satoshi Maki, Masao Koda, Mitsuhiro Kitamura, Taigo Inada, Koshiro Kamiya, Mitsutoshi Ota, Yasushi Iijima, Junya Saito, Yoshitada Masuda, Koji Matsumoto, Masatoshi Kojima, Takayuki Obata, Kazuhisa Takahashi, Masashi Yamazaki, Takeo Furuya
PURPOSE: The aim of this study was to assess the potential role of diffusion tensor imaging (DTI) as a predictor of surgical outcomes in patients with cervical compressive myelopathy (CCM). Surgical decompression is often recommended for symptomatic CCM. It is important to know the prognosis of surgical outcomes and to recommend appropriate timing for surgery. METHODS: We enrolled 26 patients with CCM who underwent surgery. The Japanese Orthopaedic Association (JOA) score for cervical myelopathy was evaluated before and 6 months after surgery...
June 16, 2017: European Spine Journal
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