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https://www.readbyqxmd.com/read/29651768/minimisation-of-signal-intensity-differences-in-distortion-correction-approaches-of-brain-magnetic-resonance-diffusion-tensor-imaging
#1
Dong-Hoon Lee, Do-Wan Lee, David Henry, Hae-Jin Park, Bong-Soo Han, Dong-Cheol Woo
OBJECTIVES: To evaluate the effects of signal intensity differences between the b0 image and diffusion tensor imaging (DTI) in the image registration process. METHODS: To correct signal intensity differences between the b0 image and DTI data, a simple image intensity compensation (SIMIC) method, which is a b0 image re-calculation process from DTI data, was applied before the image registration. The re-calculated b0 image (b0ext ) from each diffusion direction was registered to the b0 image acquired through the MR scanning (b0nd ) with two types of cost functions and their transformation matrices were acquired...
April 12, 2018: European Radiology
https://www.readbyqxmd.com/read/29623940/dti-and-pathological-changes-in-a-rabbit-model-of-radiation-injury-to-the-spinal-cord-after-125-i-radioactive-seed-implantation
#2
Xia Cao, Le Fang, Chuan-Yu Cui, Shi Gao, Tian-Wei Wang
Excessive radiation exposure may lead to edema of the spinal cord and deterioration of the nervous system. Magnetic resonance imaging can be used to judge and assess the extent of edema and to evaluate pathological changes and thus may be used for the evaluation of spinal cord injuries caused by radiation therapy. Radioactive125 I seeds to irradiate 90% of the spinal cord tissue at doses of 40-100 Gy (D90) were implanted in rabbits at T10 to induce radiation injury, and we evaluated their safety for use in the spinal cord...
March 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29619562/a-preliminary-study-of-3-0-t-magnetic-resonance-diffusion-tensor-imaging-in-cervical-spondylotic-myelopathy
#3
Fulong Dong, Yuanyuan Wu, Peiwen Song, Yinfeng Qian, Ying Wang, Liyan Xu, Minmin Yin, Renjie Zhang, Hui Tao, Peng Ge, Chang Liu, Huaqing Zhang, Jinwen Zhu, Cailiang Shen, Yongqiang Yu
PURPOSE: To compare diffusion tensor imaging (DTI) parameters of the spinal cord between patients with cervical spondylotic myelopathy (CSM) and normal subjects, and investigate their significance in the clinical diagnosis, surgical planning and post-operative evaluation of CSM. METHODS: Routine sequence magnetic resonance imaging (MRI) and DTI scans were performed in 50 normal subjects and 60 cases of CSM with 3.0-T MR. DTI images, apparent diffusion coefficient (ADC) and fractional anisotropy (FA) colormaps corresponding to spinal cord cross-sections were obtained...
April 4, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29597019/quantitative-evaluation-of-compressed-l4-5-and-s1-nerve-roots-of-lumbar-disc-herniation-patients-by-diffusion-tensor-imaging-fiber-tractography
#4
Ai He, Wen-Zheng Wang, Peng-Fei Qiao, Guo-Yong Qiao, Hao Cheng, Ping-Yong Feng
OBJECTIVE: We sought to delineate the fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values of compressed nerve roots in lumbar disc herniation patients by diffusion tensor imaging (DTI) and fiber bundle tracing and further investigated the relationship between FA or ADC values and the swiss spinal stenosis questionnaire (SSSQ) scores and the visual analog scale (VAS) scores. METHODS: Twenty patients with lumbar disc herniation and 20 age and sex-matched healthy volunteers were assessed using the SSSQ and VAS...
March 26, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29576582/the-reliability-of-reduced-field-of-view-dti-for-highly-accurate-quantitative-assessment-of-cervical-spinal-cord-tracts
#5
Takumi Yokohama, Motoyuki Iwasaki, Daisuke Oura, Sho Furuya, Tomoyuki Okuaki
PURPOSE: To compare the accuracy of fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values between reduced FOV or so-called zonally oblique multislice (ZOOM) and conventional diffusion tensor imaging (DTI) in the cervical spinal cord. METHODS: Both ZOOM and conventional DTI were performed on 10 healthy volunteers. Intraclass correlation coefficient (ICC) was used to evaluate the reliability of the measurements obtained. Four radiologists evaluated the FA and ADC values at each cervical cord level and classified the visibility by 4 ranks...
March 23, 2018: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/29504292/current-clinical-applications-of-diffusion-tensor-imaging-in-neurological-disorders
#6
REVIEW
Woo Suk Tae, Byung Joo Ham, Sung Bom Pyun, Shin Hyuk Kang, Byung Jo Kim
Diffusion-tensor imaging (DTI) is a noninvasive medical imaging tool used to investigate the structure of white matter. The signal contrast in DTI is generated by differences in the Brownian motion of the water molecules in brain tissue. Postprocessed DTI scalars can be used to evaluate changes in the brain tissue caused by disease, disease progression, and treatment responses, which has led to an enormous amount of interest in DTI in clinical research. This review article provides insights into DTI scalars and the biological background of DTI as a relatively new neuroimaging modality...
February 28, 2018: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/29485189/dynamic-diffusion-tensor-imaging-of-spinal-cord-contusion-a-canine-model
#7
Changbin Liu, Degang Yang, Jianjun Li, Dapeng Li, Mingliang Yang, Wei Sun, Qianru Meng, Wenhao Zhang, Chang Cai, Liangjie Du, Jun Li, Feng Gao, Rui Gu, Yutong Feng, Xuechao Dong, Qi Miao, Xinghua Yang, Zhentao Zuo
This study aimed to explore the dynamic diffusion tensor imaging (DTI) of changes in spinal cord contusion using a canine model of injury involving rostral and caudal levels. In this study, a spinal cord contusion model was established in female dogs using a custom-made weight-drop lesion device. DTI was performed on dogs with injured spinal cords (n=7) using a Siemens 3.0T MRI scanner at pre-contusion and at 3 h, 24 h, 6 weeks and 12 weeks post-injury. The tissue sections were stained for immunohistochemical analysis...
February 27, 2018: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/29462365/supratentorial-cavernous-malformations-involving-the-cortico-spinal-tract-and-sensory-motor-cortex-treatment-strategies-surgical-considerations-and-outcomes
#8
Miran Skrap, Maria Caterina Vescovi, Giada Pauletto, Marta Maieron, Tomasino Barbara, Daniele Bagatto, Francesco Tuniz
BACKGROUND: Cavernous malformations (CMs) are congenital malformations and may be located anywhere in the brain. We present a series of CMs located close to or inside of the motor-sensory cortex or corticospinal tract (CST) with clinical onset due to hemorrhage or mass effect. In such cases, surgery becomes an acceptable option. OBJECTIVE: To evaluate the role of diffusion tensor imaging (DTI), functional-magnetic-resonance imaging (fMRI), intraoperative neurophysiological monitoring, neuronavigation, and brain-mapping and the clinical results of surgical treatment of CMs in this critical location...
February 16, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29424671/reproducibility-temporal-stability-and-functional-correlation-of-diffusion-mr-measurements-within-the-spinal-cord-in-patients-with-asymptomatic-cervical-stenosis-or-cervical-myelopathy
#9
Benjamin M Ellingson, Noriko Salamon, Davis C Woodworth, Hajime Yokota, Langston T Holly
OBJECTIVE The purpose of this study was to quantify the reproducibility, temporal stability, and functional correlation of diffusion MR characteristics in the spinal cord in patients with cervical stenosis with or without myelopathy. The association between longitudinal diffusion tensor imaging (DTI) measurements and serial neurological function assessment was explored at both the group and individual level. METHODS Sixty-six nonoperatively treated patients with cervical stenosis were prospectively followed (3 months to > 5 years) using synchronous serial MRI and functional outcome assessment...
February 9, 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29369451/feasibility-of-single-shot-multi-level-multi-angle-diffusion-tensor-imaging-of-the-human-cervical-spinal-cord-at-7t
#10
Aurélien Massire, Henitsoa Rasoanandrianina, Manuel Taso, Maxime Guye, Jean-Philippe Ranjeva, Thorsten Feiweier, Virginie Callot
PURPOSE: Diffusion tensor imaging (DTI), which is frequently used to characterize microstructure impairments in many spinal cord diseases at clinical fields, may benefit from 7T investigations. Yet, it presents specific technical challenges, such as increased magnetic susceptibility-induced image distortions. METHODS: Eight healthy volunteers were scanned at 7T using a prototype diffusion multi-slice multi-angle (MSMA) single-shot spin-echo echo planar imaging (EPI) sequence developed to explore the whole cervical spinal cord while limiting the partial volume effects related to the cord curvature...
January 25, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29359174/quantitative-spinal-cord-mri-in-radiologically-isolated-syndrome
#11
Paula Alcaide-Leon, Kateryna Cybulsky, Stephanie Sankar, Courtney Casserly, General Leung, Marika Hohol, Daniel Selchen, Xavier Montalban, Aditya Bharatha, Jiwon Oh
Objectives: To assess whether quantitative spinal cord MRI (SC-MRI) measures, including atrophy, and diffusion tensor imaging (DTI) and magnetization transfer imaging metrics were different in radiologically isolated syndrome (RIS) vs healthy controls (HCs). Methods: Twenty-four participants with RIS and 14 HCs underwent cervical SC-MRI on a 3T magnet. Manually segmented regions of interest circumscribing the spinal cord cross-sectional area (SC-CSA) between C3 and C4 were used to extract SC-CSA, fractional anisotropy, mean, perpendicular, and parallel diffusivity (MD, λ⊥, and λ||) and magnetization transfer ratio (MTR)...
March 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29311540/diffusion-tensor-imaging-in-diagnosis-of-post-traumatic-syringomyelia-in-spinal-cord-injury-in-rats
#12
Chao Zhang, Kai Chen, Xiuxin Han, Jiayuanyuan Fu, Patricia Douglas, Anna Y Morozova, Maxim A Abakumov, Ilya L Gubsky, Dejin Li, Jin Guo, Xuening Zhang, Guowen Wang, Vladimir P Chekhonin
BACKGROUND Post-traumatic syringomyelia (PTS) is a common disease after spinal cord injury (SCI). The present study was performed to evaluate the advantages of diffusion tensor imaging (DTI) in estimating SCI and prognosing PTS in SCI rats. MATERIAL AND METHODS Forty rats were divided into 3 groups based on the extent of the individual SCI and PTS: a control group (n=10), a PTS group (n=8), and an SCI group (n=22). BBB tests were performed preoperatively and postoperatively at (1 d, 3 d, 5 d, 1 w, 2 w, 1 w, 2 w, 3 w, 4 w, 5 w, and 6 w)...
January 9, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29300252/a-follow-up-study-of-postoperative-dcm-patients-using-diffusion-mri-with-dti-and-noddi
#13
Xiaodong Ma, Xiao Han, Wen Jiang, Jinchao Wang, Zhe Zhang, Guangqi Li, Jieying Zhang, Xiaoguang Cheng, Huijun Chen, Hua Guo, Wei Tian
STUDY DESIGN: A retrospective cohort study. OBJECTIVE: To investigate the relationship between spinal cord microstructures and spinal cord dysfunction in degenerative cervical myelopathy (DCM) patients, a follow-up study was carried out using diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI), an advanced diffusion model. SUMMARY OF BACKGROUND DATA: DTI has been used for diagnosis of DCM. Though DTI has advantages of high sensitivity and quantitative features, it is limited by its low specificity for measuring microstructures...
January 3, 2018: Spine
https://www.readbyqxmd.com/read/29298564/diffusion-tensor-imaging-of-scarring-necrosis-and-cavitation-based-on-histopathological-findings-in-dogs-with-chronic-spinal-cord-injury-evaluation-of-multiple-diffusion-parameters-and-their-correlations-with-histopathological-findings
#14
Hakyoung Yoon, Won-Jin Moon, Sang-Soep Nahm, Jaehwan Kim, Kidong Eom
The use of diffusion tensor imaging (DTI) for the characterization of various lesion types in dogs with spinal cord injury (SCI) has not been investigated. The aim of this study was to characterize scarring (loose immature scarring [LIMS], intermediate mature scarring [IMS], and dense mature scarring [DMS]), necrosis, cavitation, and acute hemorrhage using multiple DTI parameters and determine the correlations between the DTI parameters and histopathological finding in dogs with controlled SCI. All imaging data were obtained from the lumbar spinal cord (from L1 to L3) of normal and SCI dogs using a 3-Tesla magnetic resonance imaging scanner...
March 29, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29227148/structural-abnormalities-and-altered-regional-brain-activity-in-multiple-sclerosis-with-simple-spinal-cord-involvement
#15
Ping Yin, Yi Liu, Hua Xiong, Yongliang Han, Shambhu Kumar Sah, Chun Zeng, Jingjie Wang, Yongmei Li
OBJECTIVE: To assess the changes of the structural and functional abnormalities in multiple sclerosis with simple spinal cord involvement (MS-SSCI) by using resting-state functional MRI (RS-fMRI), voxel based morphology (VBM) and diffusion tensor tractography. METHODS: The amplitude of low-frequency fluctuation (ALFF) of 22 patients with MS-SSCI and 22 healthy controls (HCs) matched for age, gender and education were compared by using RS-fMRI. We also compared the volume, fractional anisotropy (FA) and apparent diffusion coefficient of the brain regions in baseline brain activity by using VBM and diffusion tensor imaging...
February 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29175489/diffusion-tensor-imaging-identifies-presymptomatic-axonal-degeneration-in-the-spinal-cord-of-als-mice
#16
Rodolfo G Gatto, Weiguo Li, Richard L Magin
Extensive pathological evidence indicates that axonal degeneration represents an early and critical event in amyotrophic lateral sclerosis (ALS). Unfortunately, few MRI studies have focused in the early detection of white matter (WM) alterations in the spinal cord region. To unveil these WM changes, we performed high resolution diffusion tensor imaging (DTI) and correlated the results with histological analysis of adjacent slices taken from the spinal cords of presymptomatic mice. The DTI studies demonstrated a significant reduction in fractional anisotropy (FA) as well as axial diffusivities (AD) and an increase in radial diffusivity (RD), predominantly at lower segments of the spinal cord...
January 15, 2018: Brain Research
https://www.readbyqxmd.com/read/29174922/detecting-spinal-pyramidal-tract-of-amyotrophic-lateral-sclerosis-patients-with-diffusion-tensor-tractography
#17
Yusuke Fukui, Nozomi Hishikawa, Kota Sato, Yumiko Nakano, Ryuta Morihara, Jingwei Shang, Mami Takemoto, Yasuyuki Ohta, Toru Yamashita, Koji Abe
The objective of this study was to determine alteration of corticospinal tract in patients with amyotrophic lateral sclerosis (ALS) using diffusion tensor tractograhy (DTT) focusing on the cervical spinal cord (C5) and transcranial magnetic stimulation (TMS). We recruited 38 ALS, 6 spinal and bulbar muscular atrophy (SBMA), 7 spastic paraplegia (SP) patients, and 8 age-matched normal controls, and then ALS were divided into two subgroups according to their clinical type: 28 ALS-limb and 10 ALS-bulbar. DTT was performed using the diffusion tensor image (DTI) track module to reconstruct two fiber tracts via C5...
November 22, 2017: Neuroscience Research
https://www.readbyqxmd.com/read/29154897/identification-of-ghost-artifact-using-texture-analysis-in-pediatric-spinal-cord-diffusion-tensor-images
#18
Mahdi Alizadeh, Chris J Conklin, Devon M Middleton, Pallav Shah, Sona Saksena, Laura Krisa, Jürgen Finsterbusch, Scott H Faro, M J Mulcahey, Feroze B Mohamed
PURPOSE: Ghost artifacts are a major contributor to degradation of spinal cord diffusion tensor images. A multi-stage post-processing pipeline was designed, implemented and validated to automatically remove ghost artifacts arising from reduced field of view diffusion tensor imaging (DTI) of the pediatric spinal cord. METHOD: A total of 12 pediatric subjects including 7 healthy subjects (mean age=11.34years) with no evidence of spinal cord injury or pathology and 5 patients (mean age=10...
April 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29154896/diffusion-tensor-imaging-of-spinal-cord-parenchyma-lesion-in-rat-with-chronic-spinal-cord-injury
#19
Can Zhao, Jia-Sheng Rao, Xiao-Jiao Pei, Jian-Feng Lei, Zhan-Jing Wang, Wen Zhao, Rui-Han Wei, Zhao-Yang Yang, Xiao-Guang Li
PURPOSE: Adequate evaluation of spinal cord parenchyma and accurate identification of injury range are considered two premises for the research and treatment of chronic spinal cord injury (SCI). Diffusion tensor imaging (DTI) provides information about water diffusion in spinal cord, and thus makes it possible to realize these premises. METHOD: In this study, we conducted magnetic resonance imaging (MRI) for Wistar rats 84days after spinal cord contusion. DTI metrics including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) from different positions of the injured cord were collected, analyzed, and compared with the histological results and locomotor outcomes...
April 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29111113/understanding-the-relationship-between-brain-and-upper-limb-function-in-children-with-unilateral-motor-impairments-a-multimodal-approach
#20
Maya Weinstein, Dido Green, Julian Rudisch, Ingar M Zielinski, Marta Benthem-Muñiz, Marijtje L A Jongsma, Verity McClelland, Bert Steenbergen, Shelly Shiran, Dafna Ben Bashat, Gareth J Barker
Atypical brain development and early brain injury have profound and long lasting impact on the development, skill acquisition, and subsequent independence of a child. Heterogeneity is present at the brain level and at the motor level; particularly with respect to phenomena of bilateral activation and mirrored movements (MMs). In this multiple case study we consider the feasibility of using several modalities to explore the relationship between brain structure and/or activity and hand function: Electroencephalography (EEG), both structural and functional Magnetic Resonance Imaging (sMRI, fMRI), diffusion tensor imaging (DTI), transcranial magnetic stimulation (TMS), Electromyography (EMG) and hand function assessments...
January 2018: European Journal of Paediatric Neurology: EJPN
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