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https://www.readbyqxmd.com/read/28714054/the-functional-relevance-of-diffusion-tensor-imaging-in-comparison-to-conventional-mri-in-patients-with-cervical-compressive-myelopathy
#1
Young-Mi Yang, Woo-Kyoung Yoo, Je Hyun Yoo, Yoon Hae Kwak, Jae-Keun Oh, Ji-Sun Song, Seok Woo Kim
OBJECTIVE: To determine the functional relevance of diffusion tensor imaging (DTI) metrics and conventional MRI (signal intensity change in T2, compression ratio) by measuring the correlation of these parameters with clinical outcome measured by the modified Japanese Orthopedic Association (mJOA) score. MATERIALS AND METHODS: A total of 20 cervical myelopathy (CM) patients participated in this prospective cohort study. The severities of CM were assessed using the mJOA score...
July 17, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28711563/application-of-neurite-orientation-dispersion-and-density-imaging-or-diffusion-tensor-imaging-to-quantify-the-severity-of-cervical-spondylotic-myelopathy-and-assess-postoperative-neurological-recovery
#2
Genki Okita, Tetsuro Ohba, Tomohiro Takamura, Shigeto Ebata, Ryo Ueda, Hiroshi Onishi, Hirotaka Haro, Masaaki Hori
BACKGROUND CONTEXT: Surgical outcome and the severity of cervical spondylotic myelopathy (CSM) are unpredictable and cannot be estimated by conventional anatomical MRI. The utility of diffusion tensor imaging (DTI) to quantify the severity of CSM and assess postoperative neurological recovery has been investigated. However, whether conventional DTI should be applied in a clinical setting remains controversial. Neurite orientation dispersion and density imaging (NODDI) is a recently introduced model-based diffusion-weighted MRI technique that quantifies specific microstructural features related directly to neuronal morphology...
July 12, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28703331/high-resolution-diffusion-tensor-imaging-in-cervical-spondylotic-myelopathy-a-preliminary-follow-up-study
#3
Li Guan, Xiaolong Chen, Yong Hai, Xiaodong Ma, Le He, Guangzhi Wang, Chun Yuan, Hua Guo
Diffusion imaging is a promising technique as it can provide microstructural tissue information and thus potentially show viable changes in spinal cord. However, the traditional single-shot imaging method is limited as a result of various image artifacts. In order to improve measurement accuracy, we used a newly developed, multi-shot, high-resolution, diffusion tensor imaging (DTI) method to investigate diffusion metric changes and compare them with T2 -weighted (T2W) images before and after decompressive surgery for cervical spondylotic myelopathy (CSM)...
July 13, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28669912/the-efficiency-of-retrospective-artifact-correction-methods-in-improving-the-statistical-power-of-between-group-differences-in-spinal-cord-dti
#4
Gergely David, Patrick Freund, Siawoosh Mohammadi
Diffusion tensor imaging (DTI) is a promising approach for investigating the white matter microstructure of the spinal cord. However, it suffers from severe susceptibility, physiological, and instrumental artifacts present in the cord. Retrospective correction techniques are popular approaches to reduce these artifacts, because they are widely applicable and do not increase scan time. In this paper, we present a novel outlier rejection approach (reliability masking) which is designed to supplement existing correction approaches by excluding irreversibly corrupted and thus unreliable data points from the DTI index maps...
June 29, 2017: NeuroImage
https://www.readbyqxmd.com/read/28631276/comparison-of-two-different-analysis-approaches-for-dti-free-water-corrected-and-uncorrected-maps-in-the-study-of-white-matter-microstructural-integrity-in-individuals-with-depression
#5
Maurizio Bergamino, Rayus Kuplicki, Teresa V Victor, Yoon-Hee Cha, Martin P Paulus
Diffusion tensor imaging (DTI) has often been used to examine white matter (WM) tract abnormalities in depressed subjects, but these studies have yielded inconsistent results, probably, due to gender composition or small sample size. In this study, we applied different analysis pipelines to a relatively large sample of individuals with depression to determine whether previous findings in depression can be replicated with these pipelines. We used a "standard" DTI algorithm and maps computed through a free-water (FW) corrected DTI...
June 20, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28623403/diffusion-tensor-imaging-can-predict-surgical-outcomes-of-patients-with-cervical-compression-myelopathy
#6
Satoshi Maki, Masao Koda, Mitsuhiro Kitamura, Taigo Inada, Koshiro Kamiya, Mitsutoshi Ota, Yasushi Iijima, Junya Saito, Yoshitada Masuda, Koji Matsumoto, Masatoshi Kojima, Takayuki Obata, Kazuhisa Takahashi, Masashi Yamazaki, Takeo Furuya
PURPOSE: The aim of this study was to assess the potential role of diffusion tensor imaging (DTI) as a predictor of surgical outcomes in patients with cervical compressive myelopathy (CCM). Surgical decompression is often recommended for symptomatic CCM. It is important to know the prognosis of surgical outcomes and to recommend appropriate timing for surgery. METHODS: We enrolled 26 patients with CCM who underwent surgery. The Japanese Orthopaedic Association (JOA) score for cervical myelopathy was evaluated before and 6 months after surgery...
June 16, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28612398/polyethylene-glycol-induced-motor-recovery-after-total-spinal-transection-in-rats
#7
Shuai Ren, Ze-Han Liu, Qiong Wu, Kuang Fu, Jun Wu, Li-Ting Hou, Ming Li, Xin Zhao, Qing Miao, Yun-Long Zhao, Sheng-Yu Wang, Yan Xue, Zhen Xue, Ya-Shan Guo, Sergio Canavero, Xiao-Ping Ren
AIMS: Despite more than a century of research, spinal paralysis remains untreatable via biological means. A new understanding of spinal cord physiology and the introduction of membrane fusogens have provided new hope that a biological cure may soon become available. However, proof is needed from adequately powered animal studies. METHODS AND RESULTS: Two groups of rats (n=9, study group, n=6 controls) were submitted to complete transection of the dorsal cord at T10...
June 14, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/28597208/subject-specific-regional-measures-of-water-diffusion-are-associated-with-impairment-in-chronic-spinal-cord-injury
#8
Ann S Choe, Cristina L Sadowsky, Seth A Smith, Peter C M van Zijl, James J Pekar, Visar Belegu
PURPOSE: We aimed to identify non-invasive imaging parameters that can serve as biomarkers for the integrity of the spinal cord, which is paramount to neurological function. Diffusion tensor imaging (DTI) indices are sensitive to axonal and myelin damage, and have strong potential to serve as such biomarkers. However, averaging DTI indices over large regions of interest (ROIs), a common approach to analyzing the images of injured spinal cord, leads to loss of subject-specific information...
June 8, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28560158/application-and-evaluation-of-noddi-in-the-cervical-spinal-cord-of-multiple-sclerosis-patients
#9
Samantha By, Junzhong Xu, Bailey A Box, Francesca R Bagnato, Seth A Smith
INTRODUCTION: There is a need to develop imaging methods sensitive to axonal injury in multiple sclerosis (MS), given the prominent impact of axonal pathology on disability and outcome. Advanced multi-compartmental diffusion models offer novel indices sensitive to white matter microstructure. One such model, neurite orientation dispersion and density imaging (NODDI), is sensitive to neurite morphology, providing indices of apparent volume fractions of axons (vin), isotropic water (viso) and the dispersion of fibers about a central axis (orientation dispersion index, ODI)...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28540122/presurgical-role-of-mri-tractography-in-a-case-of-extensive-cervicothoracic-spinal-ependymoma
#10
Francesca Granata, Sergio Racchiusa, Enricomaria Mormina, Valeria Barresi, Giada Garufi, Giovanni Grasso, Francesco Maria Salpietro, Marcello Longo, Concetta Alafaci
BACKGROUND: Intramedullary spinal ependymoma is a tumor, hardly characterizable with conventional magnetic resonance (MR) imaging only. MR diffusion tensor imaging (DTI) with three-dimensional fiber-tracking reconstructions allows the evaluation of the relationship between neoplasm and white matter fiber tracts, being a powerful tool in presurgical planning. We present DTI findings in a case of a young female with an extensive cervicothoracic spinal ependymoma. CASE DESCRIPTION: The patient complained of a 2-month history of acute urinary retention, weakness and numbness on the lower limbs and the upper left limb...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28429407/spinal-cord-injury-induces-widespread-chronic-changes-in-cerebral-white-matter
#11
Tero Ilvesmäki, Eerika Koskinen, Antti Brander, Teemu Luoto, Juha Öhman, Hannu Eskola
Traumatic spinal cord injuries (SCIs) lead to axonal damage at the trauma site, as well as disconnections within the central nervous system. While the exact mechanisms of the long-term pathophysiological consequences of SCIs are not fully understood, it is known that neuronal damage and degeneration are not limited to the direct proximity of the trauma. Instead, the effects can be detected even in the cerebrum. We examined SCI-induced chronic brain changes with a case-control design using 32 patients and 70 control subjects...
April 21, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28428213/clinically-feasible-microstructural-mri-to-quantify-cervical-spinal-cord-tissue-injury-using-dti-mt-and-t2-weighted-imaging-assessment-of-normative-data-and-reliability
#12
A R Martin, B De Leener, J Cohen-Adad, D W Cadotte, S Kalsi-Ryan, S F Lange, L Tetreault, A Nouri, A Crawley, D J Mikulis, H Ginsberg, M G Fehlings
BACKGROUND AND PURPOSE: DTI, magnetization transfer, T2*-weighted imaging, and cross-sectional area can quantify aspects of spinal cord microstructure. However, clinical adoption remains elusive due to complex acquisitions, cumbersome analysis, limited reliability, and wide ranges of normal values. We propose a simple multiparametric protocol with automated analysis and report normative data, analysis of confounding variables, and reliability. MATERIALS AND METHODS: Forty healthy subjects underwent T2WI, DTI, magnetization transfer, and T2*WI at 3T in <35 minutes using standard hardware and pulse sequences...
April 20, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28428212/a-novel-mri-biomarker-of-spinal-cord-white-matter-injury-t2-weighted-white-matter-to-gray-matter-signal-intensity-ratio
#13
A R Martin, B De Leener, J Cohen-Adad, D W Cadotte, S Kalsi-Ryan, S F Lange, L Tetreault, A Nouri, A Crawley, D J Mikulis, H Ginsberg, M G Fehlings
BACKGROUND AND PURPOSE: T2*-weighted imaging provides sharp contrast between spinal cord GM and WM, allowing their segmentation and cross-sectional area measurement. Injured WM demonstrates T2*WI hyperintensity but requires normalization for quantitative use. We introduce T2*WI WM/GM signal-intensity ratio and compare it against cross-sectional area, the DTI metric fractional anisotropy, and magnetization transfer ratio in degenerative cervical myelopathy. MATERIALS AND METHODS: Fifty-eight patients with degenerative cervical myelopathy and 40 healthy subjects underwent 3T MR imaging, covering C1-C7...
April 20, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28385062/diffusion-tensor-imaging-parameter-obtained-during-acute-blunt-cervical-spinal-cord-injury-in-predicting-long-term-outcome
#14
Kathirkamanthan Shanmuganathan, Jiachen Zhuo, Hegang H Chen, Bizhan Aarabi, Jason Adams, Catriona Miller, Jay Menaker, Rao Gullapallie, Stuart E Mirvis
There are no reliable neuroimaging biomarkers to predict long term outcome following spinal cord injury. This prospective longitudinal study evaluates diffusion tensor imaging (DTI) in predicting long term outcome following cervical spinal cord injury (CSCI). We investigate the admission DTI parameters measured in 30 patients with CSCI, with 16 of them followed up to 1 year, and 15 volunteers serving as controls. All MRI examinations were performed within 24 hours of injury. DTI parameters were measured in patients and controls, avoiding areas of hemorrhage in patients and at corresponding upper/middle/lower regions of the spinal cord in controls...
April 6, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28378287/pediatric-thoracic-sciwora-after-back-bend-during-dance-practice-a-retrospective-case-series-and-analysis-of-trauma-mechanisms
#15
Jian Ren, Gao Zeng, Yong-Jie Ma, Nan Chen, Zan Chen, Feng Ling, Hong-Qi Zhang
PURPOSE: The purpose of the study was to describe a unique type of low-energy traumatic pediatric thoracic spinal cord injury without radiographic abnormality (SCIWORA) after a back bend during dance practice and analyze the trauma mechanisms and treatment protocols. METHODS: This was a retrospective case series from September 2007 to August 2016. The study was conducted at a tertiary medical center in Beijing, China (Xuanwu Hospital, China International Neuroscience Institute [China-INI], Capital Medical University)...
July 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28351750/a-longitudinal-dti-and-histological-study-of-the-spinal-cord-reveals-early-pathological-alterations-in-g93a-sod1-mouse-model-of-amyotrophic-lateral-sclerosis
#16
Stefania Marcuzzo, Silvia Bonanno, Matteo Figini, Alessandro Scotti, Ileana Zucca, Ludovico Minati, Nilo Riva, Teuta Domi, Andrea Fossaghi, Angelo Quattrini, Barbara Galbardi, Sara D'Alessandro, Maria Grazia Bruzzone, José Manuel García-Verdugo, Victoria Moreno-Manzano, Renato Mantegazza, Pia Bernasconi
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by selective motor neuron degeneration in the motor cortex, brainstem and spinal cord. It is generally accepted that ALS is caused by death of motor neurons, however the exact temporal cascade of degenerative processes is not yet completely known. To identify the early pathological changes in spinal cord of G93A-SOD1 ALS mice we performed a comprehensive longitudinal analysis employing diffusion-tensor magnetic resonance imaging alongside histology and electron microscopy, in parallel with peripheral nerve histology...
March 27, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28347419/advanced-neuroimaging-in-the-evaluation-of-spinal-cord-tumors-and-tumor-mimics-diffusion-tensor-and-perfusion-weighted-imaging
#17
Xiang Liu, Wei Tian, Hongyan Chen, Thomas A LoStracco, Jing Zhang, Michael Yan Li, Barbara Germin, Henry Z Wang
Spinal cord tumors are an important component of pathologic diseases involving the spinal cord. Conventional magnetic resonance (MR) imaging only provides anatomical information. MR diffusion tensor imaging (DTI) and MR perfusion-weighted imaging (PWI) may detect microstructure diffusion and hemodynamic changes in these tumors. We review recent application studies of MR DTI and PWI in spinal cord tumors. Overall, MR DTI and MR PWI are promising imaging tools that are especially useful in improving differential diagnosis between spinal cord tumors and tumor mimics, preoperative evaluation of resectability, and providing assistance in surgical navigation...
April 2017: Seminars in Ultrasound, CT, and MR
https://www.readbyqxmd.com/read/28320182/axial-mr-diffusion-tensor-imaging-and-tractography-in-clinical-diagnosed-and-pathology-confirmed-cervical-spinal-cord-astrocytoma
#18
Mangsuo Zhao, Bingxin Shi, Tuoyu Chen, Yuqi Zhang, Tongchao Geng, Liyan Qiao, Mingjie Zhang, Le He, Huancong Zuo, Guihuai Wang
OBJECTIVE: To evaluate the diffusion tensor imaging (DTI) and diffusion tensor tractography (DTT) features of cervical spinal cord astrocytoma. METHODS: Eleven patients with cervical spinal cord astrocytomas and 10 healthy volunteers were recruited in this study. Conventional magnetic resonance imaging (MRI) and axial DTI were performed on a 3.0T MRI system. Apparent diffusion coefficient (ADC), fractional anisotropy (FA), axial diffusivity (AD), and radial diffusivity (RD) values for the lesions were measured...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28291025/evaluation-of-reproducibility-of-diffusion-tensor-imaging-in-the-brachial-plexus-at-3-0-t
#19
Michael J Ho, Andrei Manoliu, Felix Pierre Kuhn, Bram Stieltjes, Markus Klarhöfer, Thorsten Feiweier, Magda Marcon, Gustav Andreisek
OBJECTIVE: The aim of this study was to evaluate the reproducibility of 3 T magnetic resonance imaging diffusion tensor imaging (DTI) of the brachial plexus in healthy subjects. METHODS: Ten healthy volunteers were included, and morphological and DTI sequences of the nerve roots of the brachial plexus from C5 to T1 of both sides were repeatedly acquired on a 3 T magnetic resonance system (MAGNETOM Skyra; Siemens Healthcare, Erlangen, Germany). A prototype diffusion-weighted single-shot echo-planar imaging sequence-enabling slice-specific shim adjustments was performed with b-values of 0 and 800 s/mm in 30 gradient directions, resulting in an acquisition time of about 6 minutes each in axial orientation...
August 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28269510/network-effects-and-pathways-in-deep-brain-stimulation-in-parkinson-s-disease
#20
N Koirala, V Fleischer, O Granert, G Deuschl, M Muthuraman, S Groppa
Deep brain stimulation of subthalamic nucleus (STN-DBS) became a standard therapeutic option in Parkinson's disease (PD), even though the underlying modulated network of STN-DBS is still poorly described. Probabilistic tractography and connectivity analysis as derived from diffusion tensor imaging (DTI) were performed together with modelling of implanted electrode positions and linked postoperative clinical outcome. Fifteen patients with idiopathic PD without dementia were selected for DBS treatment. After pre-processing, probabilistic tractography was run from cortical and subcortical seeds of the hypothesized network to targets represented by the positions of the active DBS contacts...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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