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https://www.readbyqxmd.com/read/28227763/network-effects-and-pathways-in-deep-brain-stimulation-in-parkinson-s-disease
#1
N Koirala, V Fleischer, O Granert, G Deuschl, M Muthuraman, S Groppa, N Koirala, V Fleischer, O Granert, G Deuschl, M Muthuraman, S Groppa
Deep brain stimulation of subthalamic nucleus (STN-DBS) became a standard therapeutic option in Parkinson's disease (PD), even though the underlying modulated network of STN-DBS is still poorly described. Probabilistic tractography and connectivity analysis as derived from diffusion tensor imaging (DTI) were performed together with modelling of implanted electrode positions and linked postoperative clinical outcome. Fifteen patients with idiopathic PD without dementia were selected for DBS treatment. After pre-processing, probabilistic tractography was run from cortical and subcortical seeds of the hypothesized network to targets represented by the positions of the active DBS contacts...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28218643/diffusion-assessment-of-cortical-changes-induced-by-traumatic-spinal-cord-injury
#2
Peng Sun, Rory K J Murphy, Paul Gamble, Ajit George, Sheng-Kwei Song, Wilson Z Ray
Promising treatments are being developed to promote functional recovery after spinal cord injury (SCI). Magnetic resonance imaging, specifically Diffusion Tensor Imaging (DTI) has been shown to non-invasively measure both axonal and myelin integrity following traumatic brain and SCI. A novel data-driven model-selection algorithm known as Diffusion Basis Spectrum Imaging (DBSI) has been proposed to more accurately delineate white matter injury. The objective of this study was to investigate whether DTI/DBSI changes that extend to level of the cerebral peduncle and internal capsule following a SCI could be correlated with clinical function...
February 17, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28207659/evaluation-of-dti-parameter-ratios-and-diffusion-tensor-tractography-grading-in-the-diagnosis-and-prognosis-prediction-of-cervical-spondylotic-myelopathy
#3
Kun Wang, Zhi Chen, Fan Zhang, Qingxin Song, Canglong Hou, Yixing Tang, Jun Wang, Shiyue Chen, Yun Bian, Qiang Hao, Hongxing Shen
STUDY DESIGN: Prospective cohort. OBJECTIVE: To explore the correlations between diffusion tensor imaging (DTI) ratios and diffusion tensor tractography (DTT) grading with clinical symptoms and outcomes of cervical spondylotic myelopathy (CSM). SUMMARY OF BACKGROUND DATA: In addition to magnetic resonance imaging (MRI) and computed tomography, DTI may be useful in understanding pathophysiology of spinal cord in earlier stages of the CSM but it may be confounded by age and cervical level, and previous studies had small sample sizes...
February 15, 2017: Spine
https://www.readbyqxmd.com/read/28173745/characterization-of-chronic-axonal-degeneration-using-diffusion-tensor-imaging-in-canine-spinal-cord-injury-a-quantitative-analysis-of-dti-parameters-according-to-histopathological-differences
#4
Hakyoung Yoon, Jaehwan Kim, Won-Jin Moon, Sang-Soep Nahm, Jun Zhao, Hyoung-Moon Kim, Kidong Eom
Diffusion tensor imaging (DTI) is more sensitive than conventional magnetic resonance imaging (MRI) for the identification of axonal degeneration. However, no study to date has used DTI to evaluate the severity of axonal degeneration in canine spinal cord injury. Therefore, the aim of this study was to characterize multi-grade axonal degeneration (mild, moderate, and severe) in a canine model of spinal cord compression injury using DTI. MRI data were obtained from six normal dogs and five dogs with lumbar spinal cord injury 78 days after spinal cord injury (L1-L3) using a 3T MRI scanner...
February 7, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28140499/deterministic-tractography-of-the-descending-tract-of-the-spinal-trigeminal-nerve-using-diffusion-tensor-imaging
#5
Daniel J Burkett, Jonathan R Garst, Jacquelyn P Hill, Anthony Kam, Douglas E Anderson
BACKGROUND AND PURPOSE: Pain information from the face enters the pons via the trigeminal nerve before creating an anatomical "elbow" that turns caudally into the spinal trigeminal tract (SpTV). Visualization of the descending tract of the trigeminal nerve as it begins its descent from the nerve root entry zone (NREZ) in the pons would improve the accuracy of current procedures aimed at altering or lesioning the trigeminal nerve within the brainstem. The focus of this study was to develop a standardized protocol using diffusion tensor imaging (DTI) and deterministic tractography methods to image the SpTV...
January 31, 2017: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/28088799/use-of-spinal-cord-diffusion-tensor-imaging-to-quantify-neural-ablation-and-evaluate-outcome-after-percutaneous-cordotomy-for-intractable-cancer-pain
#6
Aditya Vedantam, Ping Hou, T Linda Chi, Patrick M Dougherty, Kenneth R Hess, Ashwin Viswanathan
BACKGROUND: Up to 20% of patients experience only partial pain relief after percutaneous cordotomy for cancer pain. OBJECTIVE: To determine whether diffusion tensor imaging (DTI) can quantify neural ablation and help evaluate early postoperative outcomes after cordotomy. METHODS: Patients undergoing percutaneous CT-guided cordotomy for intractable cancer pain were prospectively studied. Pre- and postoperative assessment was made using the visual analog scale (VAS) on pain and the pain severity scores of the Brief Pain Inventory Short Form...
January 14, 2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28072502/wallerian-degeneration-beyond-the-corticospinal-tracts-conventional-and-advanced-mri-findings
#7
REVIEW
Yin Jie Chen, Seyed Ali Nabavizadeh, Arastoo Vossough, Sunil Kumar, Laurie A Loevner, Suyash Mohan
Wallerian degeneration (WD) is defined as progressive anterograde disintegration of axons and accompanying demyelination after an injury to the proximal axon or cell body. Since the 1980s and 1990s, conventional magnetic resonance imaging (MRI) sequences have been shown to be sensitive to changes of WD in the subacute to chronic phases. More recently, advanced MRI techniques, such as diffusion-weighted imaging (DWI) and diffusion tensor imaging (DTI), have demonstrated some of earliest changes attributed to acute WD, typically on the order of days...
November 7, 2016: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/28056284/-clinical-value-of-diffusion-tensor-imaging-parameter-value-in-evaluating-the-prognosis-of-spinal-cord-injury-in-acute-cervical-spinal-cord-injury
#8
Z M Zou, J Li, Q Y Cao, H X Lian, C N He, B Wang
Objective: To evaluate the clinical application value of diffusion tensor imaging (DTI) parameter in evaluating the prognosis of spinal cord injury in acute cervical spinal cord injury. Method: From October 2012 to December 2015, a total of 23 patients with acute cervical spinal cord injury were examined by routine MRI-T2WI high signal DTI examination, according to the American Spinal Injury Association (ASIA) damage standard. One month later according to the functional outcome of the spinal cord, all patients were divided into non improvement group (group A) 4 cases (2 cases of ASIA-A, 2 cases of grade B) and improvement group (group B) 19 cases (13 cases of ASIA-C, 5 cases of grade D, 1 case of grade B), 15 cases of healthy volunteers as the normal group (group C )...
January 3, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28025450/application-of-fiber-tractography-and-diffusion-tensor-imaging-to-evaluate-spinal-cord-diseases-in-dogs
#9
Yuko Konishi, Hiroyuki Satoh, Yasuyoshi Kuroiwa, Mizuki Kusaka, Atsushi Yamashita, Yujiro Asada, Taketoshi Asanuma
Fiber tractography is a technique capable of depicting the three-dimensional structure and connectivity of nerve fibers using serial magnetic resonance diffusion tensor imaging (DTI). To establish fiber tractography and DTI methods in veterinary clinical medicine, we evaluated fiber tractography and DTI parameters: apparent diffusion coefficient (ADC) values and fractional anisotropy (FA) values, in various spinal cord diseases. Spinal cord DTI was examined in 28 dogs with spinal cord diseases. The ADC and FA values were measured at lesion sites and cranial normal sites on spinal cords, and both values of lesion sites were compared with normal sites...
December 23, 2016: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28003162/amygdalar-and-hippocampal-connections-with-brainstem-and-spinal-cord-a-diffusion-mri-study-in-human-brain
#10
Alessandro Arrigo, Enricomaria Mormina, Alessandro Calamuneri, Michele Gaeta, Silvia Marino, Demetrio Milardi, Giuseppe Pio Anastasi, Angelo Quartarone
The limbic system has a central role for the integration of several cognitive and visceral functions through an extended network of connections involving the hippocampus and the amygdala. A number of studies performed in humans have been dedicated to the investigation of supratentorial limbic pathways by means of non-invasive MRI approaches, such as DTI. However, detection of possible limbic connections involving the brainstem and the spinal cord is still missing. Subtentorial limbic pathways have been previously studied in animals by means of invasive approaches, including viral tracing...
December 18, 2016: Neuroscience
https://www.readbyqxmd.com/read/27939797/spinal-diffusion-tensor-imaging-in-the-evaluation-of-pre-and-post-operative-severity-in-cervical-spondylotic-myelopathy-a-systematic-review-of-the-literature
#11
REVIEW
Rima S Rindler, Falgun H Chokshi, James G Malcolm, Sheila R Eshraghi, Mahmud Mossa-Basha, Jason Chu, Shekar N Kurpad, Faiz Ahmad
BACKGROUND: Diffusion tensor imaging (DTI) is increasingly investigated as a potential diagnostic and prognostic tool for symptomatic degenerative cervical pathology; however, it is yet to be validated for this purpose. OBJECTIVE: To investigate the association of pre-operative DTI signal changes and post-operative outcomes in patients with cervical spondylotic myelopathy (CSM). METHODS: We performed a systematic literature review using PubMed for clinical studies using DTI in adults undergoing operative management for CSM...
December 6, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27843690/diagnostic-potential-of-the-diffusion-tensor-tractography-with-fractional-anisotropy-in-the-diagnosis-and-treatment-of-cervical-spondylotic-and-posttraumatic-myelopathy
#12
Alessandro Landi, Gualtiero Innocenzi, Giovanni Grasso, Alessandro Meschini, Francesco Fabbiano, Paola Castri, Roberto Delfini
BACKGROUND: Diffusion tensor imaging (DTI) is a magnetic resonance imaging (MRI)-based methodology widely used for the evaluation of microstructural integrity of the central nervous system (CNS), particularly of brain white matter fibers and bundles. METHODS: The most common parameters evaluated in a DTI study are the fractional anisotropy (FA) and mean diffusivity (MD). Combining FA and MD analyses is commonly used in the evaluation of various types of brain pathologies, such as brain tumors, where a combined analysis allows an accurate tumor characterization...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/27842677/spinal-diffusion-tensor-tractography-for-differentiation-of-intramedullary-tumor-suspected-lesions
#13
K Egger, M Hohenhaus, V Van Velthoven, S Heil, H Urbach
BACKGROUND AND PURPOSE: Primary MRI diagnosis of spinal intramedullary tumor-suspected lesions can be challenging and often requires spinal biopsy or resection with a substantial risk of neurological deficits. We evaluated whether Diffusion Tensor Imaging (DTI) tractography can facilitate the differential diagnosis. MATERIALS AND METHODS: Twenty-five consecutive patients with an intramedullary tumor-suspected lesion considered for spinal surgery were studied with a Diffusion-weighted multi-shot read out segmented EPI sequence (RESOLVE)...
December 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27814138/analysis-of-the-diffusion-tensor-imaging-parameters-of-a-normal-cervical-spinal-cord-in-a-healthy-population
#14
Liang-Feng Wei, Shou-Sen Wang, Zhao-Cong Zheng, Jun Tian, Liang Xue
BACKGROUND: Diffusion tensor imaging (DTI) shows great advantage in the diagnosis of brain diseases, including cervical spinal cord (CSC) disease. This study aims to obtain the normal values of the DTI parameters for a healthy population and to establish a baseline for CSC disease diagnosis using DTI. METHODS: A total of 36 healthy adults were subjected to magnetic resonance imaging (MRI) for the entire CSC using the Siemens 3.0 T MR System. Sagittal DTI acquisition was carried out with a single-shot spin-echo echo-planar imaging (EPI) sequence along 12 non-collinear directions...
November 4, 2016: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/27789279/conditioned-medium-of-olfactory-ensheathing-cells-promotes-the-functional-recovery-and-axonal-regeneration-after-contusive-spinal-cord-injury
#15
Mengchao Gu, Zhengchao Gao, Xiaohui Li, Lei Guo, Teng Lu, Yuhuan Li, Xijing He
OBJECTIVE: To investigate the effectiveness and the potential role of olfactory ensheathing cell conditioned medium (OEC-M) to treat contusive spinal cord injury (SCI). METHODS: The contusive SCI model was established by NYU weight-drop impactor at T10 segment. Male Sprague-Dawley rats received intraperitoneal injection of control medium (Con-M, n=18), low dose OEC-M (n=18) and high dose OEC-M (n=18). Immunofluorescence was performed to identify the purity of cultured OECs...
January 1, 2017: Brain Research
https://www.readbyqxmd.com/read/27741303/reduced-field-of-view-diffusion-weighted-imaging-of-the-lumbosacral-enlargement-a-pilot-in-vivo-study-of-the-healthy-spinal-cord-at-3t
#16
Marios C Yiannakas, Francesco Grussu, Polymnia Louka, Ferran Prados, Rebecca S Samson, Marco Battiston, Daniel R Altmann, Sebastien Ourselin, David H Miller, Claudia A M Gandini Wheeler-Kingshott
Diffusion tensor imaging (DTI) has recently started to be adopted into clinical investigations of spinal cord (SC) diseases. However, DTI applications to the lower SC are limited due to a number of technical challenges, related mainly to the even smaller size of the SC structure at this level, its position relative to the receiver coil elements and the effects of motion during data acquisition. Developing methods to overcome these problems would offer new means to gain further insights into microstructural changes of neurological conditions involving the lower SC, and in turn could help explain symptoms such as bladder and sexual dysfunction...
2016: PloS One
https://www.readbyqxmd.com/read/27689421/diffusion-tensor-imaging-as-a-biomarker-for-assessing-neuronal-stem-cell-treatments-affecting-areas-distal-to-the-site-of-spinal-cord-injury
#17
Michael B Jirjis, Chris Valdez, Aditya Vedantam, Brian D Schmit, Shekar N Kurpad
OBJECTIVE The aims of this study were to determine if the morphological and functional changes induced by neural stem cell (NSC) grafts after transplantation into the rodent spinal cord can be detected using MR diffusion tensor imaging (DTI) and, furthermore, if the DTI-derived mean diffusivity (MD) metric could be a biomarker for cell transplantation in spinal cord injury (SCI). METHODS A spinal contusion was produced at the T-8 vertebral level in 40 Sprague Dawley rats that were separated into 4 groups, including a sham group (injury without NSC injection), NSC control group (injury with saline injection), co-injection control group (injury with Prograf), and the experimental group (injury with NSC and Prograf injection)...
February 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/27668273/diffusion-tensor-microscopy-data-15-6%C3%A2-%C3%AE-m-in-plane-of-white-matter-tracts-in-the-human-pig-and-rat-spinal-cord-with-corresponding-tissue-histology
#18
Jeremy J Flint, Brian Hansen, Stephen J Blackband
The following article contains nine diffusion tensor imaging (DTI) datasets acquired with magnetic resonance microscopy (MRM, 15.6 μm in-plane). All data was collected in the region bordering the ventral horn and white matter of cross sections from the spinal cord enlargements along with each sample׳s corresponding tissue histology. These data are collected in fixed spinal cord sections of varying thicknesses taken from rat (2×21 direction DTI datasets), pig (1×21 direction DTI dataset), and human (5×21 direction DTI datasets + 1×6 direction DTI dataset) tissue sources...
December 2016: Data in Brief
https://www.readbyqxmd.com/read/27609442/tract-specific-diffusion-tensor-imaging-reveals-laterality-of-neurological-symptoms-in-patients-with-cervical-compression-myelopathy
#19
Satoshi Maki, Masao Koda, Junya Saito, Sho Takahashi, Taigo Inada, Koshiro Kamiya, Mitsutoshi Ota, Yasushi Iijima, Yoshitada Masuda, Koji Matsumoto, Masatoshi Kojima, Kazuhisa Takahashi, Takayuki Obata, Masashi Yamazaki, Takeo Furuya
BACKBROUND: Patients with cervical compression myelopathy (CCM) generally present bilateral neurological symptoms in their extremities. However, a substantial portion of patients with CCM exhibit laterality of neurological symptoms. The aim of this study was to assess the correlation between intrinsic structural damage and laterality of symptoms using spinal cord diffusion tensor imaging (DTI) of the corticospinal tract. METHODS: We enrolled 10 healthy volunteers and 40 patients with CCM in this study...
September 5, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27598689/diffusion-mri-of-the-spinal-cord-from-structural-studies-to-pathology
#20
Yoram Cohen, Debbie Anaby, Darya Morozov
Diffusion MRI is extensively used to study brain microarchitecture and pathologies, and water diffusion appears highly anisotropic in the white matter (WM) of the spinal cord (SC). Despite these facts, the use of diffusion MRI to study the SC, which has increased in recent years, is much less common than that in the brain. In the present review, after a brief outline of early studies of diffusion MRI (DWI) and diffusion tensor MRI (DTI) of the SC, we provide a short survey on DTI and on diffusion MRI methods beyond the tensor that have been used to study SC microstructure and pathologies...
September 6, 2016: NMR in Biomedicine
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