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dti spinal

Marios C Yiannakas, Francesco Grussu, Polymnia Louka, Ferran Prados, Rebecca S Samson, Marco Battiston, Daniel R Altmann, Sebastien Ourselin, David H Miller, Claudia A M Gandini Wheeler-Kingshott
Diffusion tensor imaging (DTI) has recently started to be adopted into clinical investigations of spinal cord (SC) diseases. However, DTI applications to the lower SC are limited due to a number of technical challenges, related mainly to the even smaller size of the SC structure at this level, its position relative to the receiver coil elements and the effects of motion during data acquisition. Developing methods to overcome these problems would offer new means to gain further insights into microstructural changes of neurological conditions involving the lower SC, and in turn could help explain symptoms such as bladder and sexual dysfunction...
2016: PloS One
Michael B Jirjis, Chris Valdez, Aditya Vedantam, Brian D Schmit, Shekar N Kurpad
OBJECTIVE The aims of this study were to determine if the morphological and functional changes induced by neural stem cell (NSC) grafts after transplantation into the rodent spinal cord can be detected using MR diffusion tensor imaging (DTI) and, furthermore, if the DTI-derived mean diffusivity (MD) metric could be a biomarker for cell transplantation in spinal cord injury (SCI). METHODS A spinal contusion was produced at the T-8 vertebral level in 40 Sprague Dawley rats that were separated into 4 groups, including a sham group (injury without NSC injection), NSC control group (injury with saline injection), co-injection control group (injury with Prograf), and the experimental group (injury with NSC and Prograf injection)...
September 30, 2016: Journal of Neurosurgery. Spine
Jeremy J Flint, Brian Hansen, Stephen J Blackband
The following article contains nine diffusion tensor imaging (DTI) datasets acquired with magnetic resonance microscopy (MRM, 15.6 μm in-plane). All data was collected in the region bordering the ventral horn and white matter of cross sections from the spinal cord enlargements along with each sample׳s corresponding tissue histology. These data are collected in fixed spinal cord sections of varying thicknesses taken from rat (2×21 direction DTI datasets), pig (1×21 direction DTI dataset), and human (5×21 direction DTI datasets + 1×6 direction DTI dataset) tissue sources...
December 2016: Data in Brief
Satoshi Maki, Masao Koda, Junya Saito, Sho Takahashi, Taigo Inada, Koshiro Kamiya, Mitsutoshi Ota, Yasushi Iijima, Yoshitada Masuda, Koji Matsumoto, Masatoshi Kojima, Kazuhisa Takahashi, Takayuki Obata, Masashi Yamazaki, Takeo Furuya
BACKBROUND: Patients with cervical compression myelopathy (CCM) generally present bilateral neurological symptoms in their extremities. However, a substantial portion of patients with CCM exhibit laterality of neurological symptoms. The aim of this study was to assess the correlation between intrinsic structural damage and laterality of symptoms using spinal cord diffusion tensor imaging (DTI) of the corticospinal tract. METHODS: We enrolled 10 healthy volunteers and 40 patients with CCM in this study...
September 5, 2016: World Neurosurgery
Yoram Cohen, Debbie Anaby, Darya Morozov
Diffusion MRI is extensively used to study brain microarchitecture and pathologies, and water diffusion appears highly anisotropic in the white matter (WM) of the spinal cord (SC). Despite these facts, the use of diffusion MRI to study the SC, which has increased in recent years, is much less common than that in the brain. In the present review, after a brief outline of early studies of diffusion MRI (DWI) and diffusion tensor MRI (DTI) of the SC, we provide a short survey on DTI and on diffusion MRI methods beyond the tensor that have been used to study SC microstructure and pathologies...
September 6, 2016: NMR in Biomedicine
Brian Hansen, Sune Nørhøj Jespersen
Here we describe and provide diffusion magnetic resonance imaging (dMRI) data that was acquired in neural tissue and a physical phantom. Data acquired in biological tissue includes: fixed rat brain (acquired at 9.4 T) and spinal cord (acquired at 16.4 T) and in normal human brain (acquired at 3 T). This data was recently used for evaluation of diffusion kurtosis imaging (DKI) contrasts and for comparison to diffusion tensor imaging (DTI) parameter contrast. The data has also been used to optimize b-values for ex vivo and in vivo fast kurtosis imaging...
2016: Scientific Data
Raphael Fernandes Casseb, Jean Levi Ribeiro de Paiva, Lucas Melo Teixeira Branco, Alberto Rolim Muro Martinez, Fabiano Reis, José Carlos de Lima-Junior, Gabriela Castellano, Marcondes Cavalcante França Junior
INTRODUCTION: We investigated whether MR diffusion tensor imaging (DTI) analysis of the cervical spinal cord could aid the (differential) diagnosis of sensory neuronopathies, an underdiagnosed group of diseases of the peripheral nervous system. METHODS: We obtained spinal cord DTI and T2WI at 3 T from 28 patients, 14 diabetic subjects with sensory-motor distal polyneuropathy, and 20 healthy controls. We quantified DTI-based parameters and looked at the hyperintense T2W signal at the spinal cord posterior columns...
August 25, 2016: Neuroradiology
Brian Hansen, Noam Shemesh, Sune Nørhøj Jespersen
Diffusion kurtosis imaging (DKI) is being increasingly reported to provide sensitive biomarkers of subtle changes in tissue microstructure. However, DKI also imposes larger data requirements than diffusion tensor imaging (DTI), hence, the widespread adaptation and exploration of DKI would benefit from more efficient acquisition and computational methods. To meet this demand, we recently developed a method capable of estimating mean kurtosis with only 13 diffusion weighted images. This approach was later shown to provide very accurate mean kurtosis estimates and to be more efficient in terms of contrast to noise per unit time...
August 15, 2016: NeuroImage
M Alizadeh, A Intintolo, D M Middleton, C J Conklin, S H Faro, M J Mulcahey, F B Mohamed
STUDY DESIGN: Quantitative study. OBJECTIVES: To evaluate the effectiveness of pediatric spinal cord diffusion tensor tractography (DTT) generated from reduced field of view diffusion tensor imaging (DTI) data and investigate whether there are differences in these values between typically developing (TD) subjects and patients with spinal cord injury (SCI). SETTING: Temple University Hospital and Shriners Hospitals for Children-Philadelphia, USA...
August 16, 2016: Spinal Cord
Atira S Bick, Zeev Meiner, Marc Gotkine, Netta Levin
BACKGROUND: Neurolathyrism is a toxic nutritional disorder caused by consumption of the grass pea, Lathyrus sativus. The disease, which manifests as an acute or insidiously evolving spastic paraparesis, continues to occur throughout Africa and Asia. Research on this disease is limited, and to our knowledge no imaging studies of patients with neurolathyrism have been published. OBJECTIVES: To better localize the site of damage in neurolathyrism using advanced imaging methods...
June 2016: Israel Medical Association Journal: IMAJ
Francesca Gilli, Xi Chen, Andrew R Pachner, Barjor Gimi
Disease in the spinal cord is a major component of disability in multiple sclerosis, yet current techniques of imaging spinal cord injury are insensitive and nonspecific. This study seeks to remove this major impediment to research in multiple sclerosis and other spinal cord diseases by identifying reliable biomarkers of disability progression using diffusion tensor imaging (DTI), a magnetic resonance imaging technique, to evaluate the spinal cord in a model of multiple sclerosis, i.e. the Theiler's Murine Encephalitis Virus-Induced Demyelinating Disease (TMEV-IDD)...
2016: PloS One
S Saksena, D M Middleton, L Krisa, P Shah, S H Faro, R Sinko, J Gaughan, J Finsterbusch, M J Mulcahey, F B Mohamed
BACKGROUND AND PURPOSE: DTI data of the normal healthy spinal cord in children are limited compared with adults and are typically focused on the cervical spinal cord. The purpose of this study was the following: to investigate the feasibility of obtaining repeatable DTI parameters along the entire cervical and thoracic spinal cord as a function of age in typically developing pediatric subjects; to analyze the DTI parameters among different transverse levels of the cervical and thoracic spinal cord; and to examine the sex differences in DTI parameters along the cervical and thoracic spinal cord...
July 14, 2016: AJNR. American Journal of Neuroradiology
Erik Curtis, Brandon C Gabel, Martin Marsala, Joseph D Ciacci
INTRODUCTION: Spinal cord injury (SCI) resulting in paraplegia or quadriplegia is a significant burden in the world. It is estimated that there are approximately 250 000 people living with SCI in the United States alone. Our study offered the direct implantation of human-derived stem cells into the spinal cord of subjects who have chronic SCI. The primary objective of the study is to determine the safety and toxicity of human spinal stem cell transplantation for the treatment of paralysis...
August 2016: Neurosurgery
Allan R Martin, Benjamin De Leener, Julien Cohen-Adad, Izabela Aleksanderek, David W Cadotte, Sukhvinder Kalsi-Ryan, Lindsay Tetreault, Adrian Crawley, Howard J Ginsberg, Michael G Fehlings
INTRODUCTION: Diffusion tensor imaging (DTI), magnetization transfer (MT), and T2*-weighted imaging measure aspects of spinal cord microstructure. This study investigates if these techniques can quantify injury to individual white matter (WM) tracts and correlate with focal neurological impairments in degenerative cervical myelopathy (DCM). METHODS: Fifty-seven DCM patients (age 56.7; 61% male; 32 mild, 16 moderate, 9 severe) underwent comprehensive clinical assessments and multimodal MRI (3T GE)...
August 2016: Neurosurgery
Aditya Vedantam, Ping Hou, Linda Chi, Patrick M Dougherty, Ashwin Viswanathan
INTRODUCTION: Percutaneous cordotomy for intractable cancer pain has variable efficacy. One potential cause is the inability to quantify neural ablation. Diffusion tensor imaging (DTI) can quantify microstructural changes within the spinal cord after neural injury. We aimed to determine if DTI metrics within the spinal cord could quantify neural ablation and evaluate early postoperative outcomes. METHODS: This prospective study was performed on patients undergoing percutaneous CT-guided cordotomy for unilateral intractable cancer pain...
August 2016: Neurosurgery
Kun Wang, Zhi Chen, Fan Zhang, Qingxin Song, Canglong Hou, Yixing Tang, Jun Wang, Shiyue Chen, Yun Bian, Qiang Hao, Hongxing Shen
STUDY DESIGN: Prospective cohort. OBJECTIVE: To explore the correlations between diffusion tensor imaging (DTI) ratios and diffusion tensor tractography (DTT) grading with clinical symptoms and outcomes of cervical spondylotic myelopathy (CSM). SUMMARY OF BACKGROUND DATA: In addition to magnetic resonance imaging (MRI) and compute tomography, DTI may be useful in understanding pathophysiology of spinal cord in earlier stages of the CSM but it may be confounded by age and cervical level, and previous studies had small sample sizes...
July 7, 2016: Spine
Faith H Brennan, Nyoman D Kurniawan, Jana Vukovic, Perry F Bartlett, Fabian Käsermann, Thiruma V Arumugam, Milan Basta, Marc J Ruitenberg
OBJECTIVE: Traumatic spinal cord injury (SCI) elicits immediate neural cell death, axonal damage, and disruption of the blood-spinal cord barrier, allowing circulating immune cells and blood proteins into the spinal parenchyma. The inflammatory response to SCI involves robust complement system activation, which contributes to secondary injury and impairs neurological recovery. This study aimed to determine whether intravenous immunoglobulin (IVIg), an FDA-approved treatment for inflammatory conditions, can scavenge complement activation products and improve recovery from contusive SCI...
July 2016: Annals of Clinical and Translational Neurology
A Crombe, N Alberti, B Hiba, M Uettwiller, V Dousset, T Tourdias
BACKGROUND AND PURPOSE: Reduced-FOV DTI is promising for exploring the cervical spinal cord, but the optimal set of parameters needs to be clarified. We hypothesized that the number of excitations should be favored over the number of diffusion gradient directions regarding the strong orientation of the cord in a single rostrocaudal axis. MATERIALS AND METHODS: Fifteen healthy individuals underwent cervical spinal cord MR imaging at 3T, including an anatomic 3D-Multi-Echo Recombined Gradient Echo, high-resolution full-FOV DTI with a NEX of 3 and 20 diffusion gradient directions and 5 sets of reduced-FOV DTIs differently balanced in terms of NEX/number of diffusion gradient directions: (NEX/number of diffusion gradient directions = 3/20, 5/16, 7/12, 9/9, and 12/6)...
June 30, 2016: AJNR. American Journal of Neuroradiology
Miloš Keřkovský, Josef Bednařík, Barbora Jurová, Ladislav Dušek, Zdeněk Kadaňka, Zdeněk Kadaňka, Martin Němec, Ivana Kovaľová, Andrea Šprláková-Puková, Marek Mechl
BACKGROUND AND PURPOSE: Diffusion tensor imaging (DTI) has previously been used as a biomarker of myelopathy in patients with degenerative cervical cord compression (DCCC). However, many factors may affect the diffusion properties of the spinal cord. This prospective study seeks to identify sources of variability in spinal cord DTI parameters in both DCCC patients and healthy subjects. METHODS: The study group included 130 patients with DCCC confirmed by magnetic resonance imaging and 71 control subjects without signs of DCCC...
June 16, 2016: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
Félix P Kuhn, Antoine Feydy, Nathalie Launay, Marie-Martine Lefevre-Colau, Serge Poiraudeau, Sébastien Laporte, Marc A Maier, Pavel Lindberg
INTRODUCTION: The study aims to assess the influence of neck extension on water diffusivity within the cervical spinal cord. METHODS: IRB approved the study in 22 healthy volunteers. All subjects underwent anatomical MR and diffusion tensor imaging (DTI) at 1.5 T. The cervical cord was imaged in neutral (standard) position and extension. Segmental vertebral rotations were analyzed on sagittal T2-weighted images using the SpineView® software. Spinal cord diffusivity was measured in cross-sectional regions of interests at multiple levels (C1-C5)...
September 2016: Neuroradiology
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