keyword
MENU ▼
Read by QxMD icon Read
search

Sneddon's

keyword
https://www.readbyqxmd.com/read/28633003/assessment-of-selected-overdose-poisoning-indicators-in-health-care-administrative-data-in-4-states-2012
#1
Beth Hume, Barbara Gabella, Jeanne Hathaway, Scott Proescholdbell, Cristy Sneddon, Elizabeth Brutsch, Riley Hedin, Christopher J Drucker
OBJECTIVES: In 2012, a consensus document was developed on drug overdose poisoning definitions. We took the opportunity to apply these new definitions to health care administrative data in 4 states. Our objective was to calculate and compare drug (particularly opioid) poisoning rates in these 4 states for 4 selected Injury Surveillance Workgroup 7 (ISW7) drug poisoning indicators, using 2 ISW7 surveillance definitions, Option A and Option B. We also identified factors related to the health care administrative data used by each state that might contribute to poisoning rate variations...
January 1, 2017: Public Health Reports
https://www.readbyqxmd.com/read/28621048/exploring-the-impact-of-endometriosis-on-partners
#2
Devini Ameratunga, Tina Flemming, Donald Angstetra, Shu-Kay Ng, Anne Sneddon
AIM: This study aimed to determine how endometriosis affects the quality of life of partners of women who suffer from this disease and how it impacts their relationships, finances, mental states, and daily living. METHODS: This was a questionnaire-based cohort study that took place at a large tertiary hospital gynecology unit, which covered two sites. Fifty-one partners of women who had surgically diagnosed endometriosis agreed to participate in the study and returned completed surveys...
June 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28577549/whole-exome-sequencing-of-an-asbestos-induced-wild-type-murine-model-of-malignant-mesothelioma
#3
Sophie Sneddon, Ann-Marie Patch, Ian M Dick, Stephen Kazakoff, John V Pearson, Nicola Waddell, Richard J N Allcock, Robert A Holt, Bruce W S Robinson, Jenette Creaney
BACKGROUND: Malignant mesothelioma (MM) is an aggressive cancer of the pleural and peritoneal cavities caused by exposure to asbestos. Asbestos-induced mesotheliomas in wild-type mice have been used extensively as a preclinical model because they are phenotypically identical to their human counterpart. However, it is not known if the genetic lesions in these mice tumours are similar to in the human disease, a prerequisite for any new preclinical studies that target genetic abnormalities...
June 2, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28576768/defining-epithelial-cell-dynamics-and-lineage-relationships-in-the-developing-lacrimal-gland
#4
D'Juan Farmer, Sara Nathan, Jennifer Finley, Kevin Shengyang Yu, Elaine Emmerson, Lauren Byrnes, Julie Sneddon, Michael McManus, Aaron Tward, Sarah Knox
The tear producing lacrimal gland is a tubular organ that protects and lubricates the ocular surface. While the lacrimal gland possesses many features that make it an excellent model to understand tubulogenesis, the cell types and lineage relationships that drive lacrimal gland formation are unclear. Using single cell sequencing and other molecular tools, we reveal novel cell identities and epithelial lineage dynamics that underlie lacrimal gland development. We show that the lacrimal gland from its earliest developmental stages is composed of multiple subpopulations of immune, epithelial, and mesenchymal cell lineages...
June 2, 2017: Development
https://www.readbyqxmd.com/read/28559813/interruption-of-sneddon-wilkinson-subcorneal-pustulation-with-infliximab
#5
REVIEW
Lorenz Kretschmer, Julia-Tatjana Maul, Thomas Hofer, Alexander A Navarini
Subcorneal pustular dermatosis (SCPD, Sneddon-Wilkinson disease) is a rare chronic-relapsing skin disorder that typically manifests as flaccid sterile pustules without systemic symptoms. Although the accumulation of neutrophils is acknowledged to be a hallmark of SCPD, its exact pathomechanism is still not known. Several chemotactic factors have been implicated in neutrophil recruitment and invasion, including the proinflammatory cytokine TNF-α. These findings correspond well with clinical reports of successful off-label use of TNF blocking agents in cases that were refractory to first-line therapy, mostly with dapsone...
January 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/28552198/evaluating-the-clinical-validity-of-gene-disease-associations-an-evidence-based-framework-developed-by-the-clinical-genome-resource
#6
Natasha T Strande, Erin Rooney Riggs, Adam H Buchanan, Ozge Ceyhan-Birsoy, Marina DiStefano, Selina S Dwight, Jenny Goldstein, Rajarshi Ghosh, Bryce A Seifert, Tam P Sneddon, Matt W Wright, Laura V Milko, J Michael Cherry, Monica A Giovanni, Michael F Murray, Julianne M O'Daniel, Erin M Ramos, Avni B Santani, Alan F Scott, Sharon E Plon, Heidi L Rehm, Christa L Martin, Jonathan S Berg
With advances in genomic sequencing technology, the number of reported gene-disease relationships has rapidly expanded. However, the evidence supporting these claims varies widely, confounding accurate evaluation of genomic variation in a clinical setting. Despite the critical need to differentiate clinically valid relationships from less well-substantiated relationships, standard guidelines for such evaluation do not currently exist. The NIH-funded Clinical Genome Resource (ClinGen) has developed a framework to define and evaluate the clinical validity of gene-disease pairs across a variety of Mendelian disorders...
June 1, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/28535834/the-potential-impact-of-compositional-changes-in-farmed-fish-on-its-health-giving-properties-is-it-time-to-reconsider-current-dietary-recommendations
#7
Baukje de Roos, Alan A Sneddon, Matthew Sprague, Graham W Horgan, Ingeborg A Brouwer
Assessment of national dietary guidelines in a number of European countries reveals that some are based on cohort studies, focusing on total seafood consumption, while others are based on the content of EPA and DHA, distinguishing between oily and other fish. The mean actual intake of fish in most countries is around or below the recommended intake, with differences in intake of fish being present between sex and age groups. Many people do not reach the national recommendation for total fish intake. Dietary recommendations for fish and EPA/DHA are based mainly on data collected more than 10 years ago...
May 24, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28467219/british-lymphology-society-update
#8
Margaret Sneddon
No abstract text is available yet for this article.
May 1, 2017: British Journal of Community Nursing
https://www.readbyqxmd.com/read/28467218/think-lymphoedema
#9
Margaret Sneddon
No abstract text is available yet for this article.
May 1, 2017: British Journal of Community Nursing
https://www.readbyqxmd.com/read/28424313/reduction-in-activity-by-noxious-chemical-stimulation-is-ameliorated-by-immersion-in-analgesic-drugs-in-zebrafish
#10
Javier Lopez-Luna, Qussay Al-Jubouri, Waleed Al-Nuaimy, Lynne U Sneddon
Research has recently demonstrated that larval zebrafish show similar molecular responses to nociception to those of adults. Our study explored whether unprotected larval zebrafish exhibited altered behaviour after exposure to noxious chemicals and screened a range of analgesic drugs to determine their efficacy to reduce these responses. This approach aimed to validate larval zebrafish as a reliable replacement for adults as well as providing a high-throughput means of analysing behavioural responses. Zebrafish at 5 days post-fertilization were exposed to known noxious stimuli: acetic acid (0...
April 15, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28260569/peter-elmer-witchcraft-witch-hunting-and-politics-in-early-modern-england-oxford-oxford-university-press-2016-pp-%C3%A2-384-%C3%A2-65-00-hardback-isbn-%C3%A2-978-0-19-19-871772-0
#11
https://www.readbyqxmd.com/read/28238198/the-social-historical-and-institutional-contingencies-of-dam-removal
#12
F J Magilligan, C S Sneddon, C A Fox
Environmental managers in the United States and elsewhere are increasingly perceiving dam removal as a critical tool for river restoration and enhancing watershed resilience. In New England, over 125 dams have been dismantled for ecological and economic rationales. A surprising number of these removals, including many that are ongoing, have generated heated conflicts between restoration proponents and local communities who value their dammed landscapes. Using a comparative case study approach, we examine the environmental conflict around efforts to remove six dams in New England...
February 25, 2017: Environmental Management
https://www.readbyqxmd.com/read/28235801/the-scaffolding-protein-nherf1-regulates-the-stability-and-activity-of-the-tyrosine-kinase-her2
#13
Jaekwang Jeong, Joshua N VanHouten, Wonnam Kim, Pamela Dann, Catherine Sullivan, Jungmin Choi, W Bruce Sneddon, Peter A Friedman, John J Wysolmerski
We examined whether the scaffolding protein sodium-hydrogen exchanger regulatory factor 1 (NHERF1) interacts with the calcium pump PMCA2 and the tyrosine kinase receptor ErbB2/HER2 in normal mammary epithelial cells and breast cancer cells. NHERF1 interacts with the PDZ-binding motif in PMCA2 in both normal and malignant breast cells. NHERF1 expression is increased in HER2-positive breast cancers and correlates with HER2-positive status in human ductal carcinoma in situ (DCIS) lesions and invasive breast cancers as well as with increased mortality in patients...
April 21, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28166193/a-loop-of-cancer-stroma-cancer-interaction-promotes-peritoneal-metastasis-of-ovarian-cancer-via-tnf%C3%AE-tgf%C3%AE-egfr
#14
T-S Lau, L K-Y Chan, E C-H Wong, C W-C Hui, K Sneddon, T-H Cheung, S-F Yim, J H-S Lee, C S-Y Yeung, T K-H Chung, J Kwong
Peritoneum is the most common site for ovarian cancer metastasis. Here we investigate how cancer epigenetics regulates reciprocal tumor-stromal interactions in peritoneal metastasis of ovarian cancer. Firstly, we find that omental stromal fibroblasts enhance colony formation of metastatic ovarian cancer cells, and de novo expression of transforming growth factor-alpha (TGF-α) is induced in stromal fibroblasts co-cultured with ovarian cancer cells. We also observed an over-expression of tumor necrosis factor-alpha (TNF-α) in ovarian cancer cells, which is regulated by promoter DNA hypomethylation as well as chromatin remodeling...
February 6, 2017: Oncogene
https://www.readbyqxmd.com/read/28112424/exercise-and-the-multidisciplinary-holistic-approach-to-adolescent-dysautonomia
#15
K R Armstrong, A M De Souza, P L Sneddon, J E Potts, V E Claydon, S Sanatani
AIM: To determine whether an eight-week strength training programme as part of a multidisciplinary approach would minimise symptoms and improve quality of life in patients with dysautonomia. METHODS: Adolescents referred to a tertiary-level cardiology service from May 2014-December 2015 with symptoms of dysautonomia were eligible. Participants completed an exercise test and a quality of life (QoL) questionnaire (PedsQL) prior to the intervention. Participants were asked to complete exercises five times per week...
January 23, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28108048/bullous-pseudobullous-pustular-dermatoses
#16
REVIEW
Mark R Wick
Several dermatoses are typified by the formation of spaces (blisters; bullae) within or beneath the epidermis. These may be acellular or filled with particular species of inflammatory cells. Etiological categories include infectious, immune-mediated, genetic, drug-related, and idiopathic lesions. Examples of such disorders include impetigo, Herpes virus infections, pemphigus, bullous pemphigoid and pemphigoid gestationis, epidermolysis bullosa acquisita, IgA-related dermatoses, inherited epidermolysis bullosa variants, Hailey-Hailey disease, and porphyria cutanea tarda...
May 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/27874892/idiopathic-livedo-racemosa-presenting-with-splenomegaly-and-diffuse-lymphadenopathy
#17
Laura Bukavina, Joshua Weaver, Teri Nagy, Robert T Brodell, Eliot N Mostow
Sneddon syndrome (SS) is a rare condition and the diagnosis is made only when other more common disease entities have been excluded. Common manifestations in SS patients include hypertension, coronary artery disease, venous thrombosis, miscarriages, psychiatric disturbances, and arterial and venous thrombotic events. Most patients present in their early 30s with classic neurovascular and dermatologic signs. Currently, the main criteria for the diagnosis of SS include livedo racemosa, focal neurological deficits or evidence of stroke on magnetic resonance imaging, or characteristic vascular alterations seen on biopsy...
October 2016: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/27832122/inducing-cold-sensitivity-in-the-frigophilic-fly-drosophila-montana-by-rnai
#18
Felipe M Vigoder, Darren J Parker, Nicola Cook, Océane Tournière, Tanya Sneddon, Michael G Ritchie
Cold acclimation is a critical physiological adaptation for coping with seasonal cold. By increasing their cold tolerance individuals can remain active for longer at the onset of winter and can recover more quickly from a cold shock. In insects, despite many physiological studies, little is known about the genetic basis of cold acclimation. Recently, transcriptomic analyses in Drosophila virilis and D. montana revealed candidate genes for cold acclimation by identifying genes upregulated during exposure to cold...
2016: PloS One
https://www.readbyqxmd.com/read/27759698/occlusive-nonvasculitic-vasculopathy-a-review
#19
Mar Llamas-Velasco, Victoria Alegría, Ángel Santos-Briz, Lorenzo Cerroni, Heinz Kutzner, Luis Requena
We review the most characteristic clinical and histopathologic findings of the cutaneous manifestations of the occlusive nonvasculitic vasculopathic disorders. Clinically, most of these conditions are characterized by retiform purpura. Histopathologic findings consist of occlusion of the vessel lumina with no vasculitis. Different disorders may produce nonvasculitic occlusive vasculopathy in cutaneous blood and lymphatic vessels, including embolization due to cholesterol and oxalate emboli, cutaneous intravascular metastasis from visceral malignancies, atrial myxomas, intravascular angiosarcoma, intralymphatic histiocytosis, intravascular lymphomas, endocarditis, crystal globulin vasculopathy, hypereosinophilic syndrome, and foreign material...
October 18, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27742664/a-bioimage-informatics-platform-for-high-throughput-embryo-phenotyping
#20
James M Brown, Neil R Horner, Thomas N Lawson, Tanja Fiegel, Simon Greenaway, Hugh Morgan, Natalie Ring, Luis Santos, Duncan Sneddon, Lydia Teboul, Jennifer Vibert, Gagarine Yaikhom, Henrik Westerberg, Ann-Marie Mallon
High-throughput phenotyping is a cornerstone of numerous functional genomics projects. In recent years, imaging screens have become increasingly important in understanding gene-phenotype relationships in studies of cells, tissues and whole organisms. Three-dimensional (3D) imaging has risen to prominence in the field of developmental biology for its ability to capture whole embryo morphology and gene expression, as exemplified by the International Mouse Phenotyping Consortium (IMPC). Large volumes of image data are being acquired by multiple institutions around the world that encompass a range of modalities, proprietary software and metadata...
October 14, 2016: Briefings in Bioinformatics
keyword
keyword
73870
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"