Ened Rodríguez-Urgellés, Diana Casas-Torremocha, Anna Sancho-Balsells, Iván Ballasch, Esther García-García, Lluis Miquel-Rio, Arnau Manasanch, Ignacio Del Castillo, Wanqi Chen, Anika Pupak, Veronica Brito, Daniel Tornero, Manuel J Rodríguez, Analia Bortolozzi, Maria V Sanchez-Vives, Albert Giralt, Jordi Alberch
BACKGROUND: Huntington's Disease (HD) is a disorder that affects body movements. Altered glutamatergic innervation of the striatum is a major hallmark of the disease. Approximately 30% of those glutamatergic inputs come from thalamic nuclei. Foxp2 is a transcription factor involved in cell differentiation and reported low in patients with HD. However, the role of the Foxp2 in the thalamus in HD remains unexplored. METHODS: We used two different mouse models of HD, the R6/1 and the HdhQ111 mice, to demonstrate a consistent thalamic Foxp2 reduction in the context of HD...
November 21, 2023: Cellular and Molecular Life Sciences: CMLS