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https://www.readbyqxmd.com/read/29627817/quantitative-fibronectin-to-help-decision-making-in-women-with-symptoms-of-preterm-labour-quids-part-1-individual-participant-data-meta-analysis-and-health-economic-analysis
#1
Sarah J Stock, Lisa M Wotherspoon, Kathleen A Boyd, Rachel K Morris, Jon Dorling, Lesley Jackson, Manju Chandiramani, Anna L David, Asma Khalil, Andrew Shennan, Victoria Hodgetts Morton, Tina Lavender, Khalid Khan, Susan Harper-Clarke, Ben W Mol, Richard D Riley, John Norrie, Jane E Norman
INTRODUCTION: The aim of the QUIDS study is to develop a decision support tool for the management of women with symptoms and signs of preterm labour, based on a validated prognostic model using quantitative fetal fibronectin (qfFN) concentration, in combination with clinical risk factors. METHODS AND ANALYSIS: The study will evaluate the Rapid fFN 10Q System (Hologic, Marlborough, Massachusetts) which quantifies fFN in a vaginal swab. In part 1 of the study, we will develop and internally validate a prognostic model using an individual participant data (IPD) meta-analysis of existing studies containing women with symptoms of preterm labour alongside fFN measurements and pregnancy outcome...
April 7, 2018: BMJ Open
https://www.readbyqxmd.com/read/29558466/candidate-genes-for-first-flower-node-identified-in-pepper-using-combined-slaf-seq-and-bsa
#2
Xiaofen Zhang, Guoyun Wang, Bin Chen, Heshan Du, Fenglan Zhang, Haiying Zhang, Qian Wang, Sansheng Geng
First flower node (FFN) is an important trait for evaluating fruit earliness in pepper (Capsicum annuum L.), but the genetic mechanisms that control FFN are still poorly understood. In the present study, we developed 249 F2 plants derived from an intraspecific cross between the inbred pepper lines Z4 and Z5. Thirty plants with the highest FFN and 30 plants with the lowest FFN were chosen and their DNAs were pooled according to phenotype to construct two bulked DNA pools. Specific-locus amplified fragment sequencing (SLAF-seq) was combined with bulked segregant analysis (BSA) to identify candidate regions related to FFN...
2018: PloS One
https://www.readbyqxmd.com/read/29426794/spanish-national-hip-fracture-registry-snhfr-a-description-of-its-objectives-methodology-and-implementation
#3
P Sáez-López, J I González-Montalvo, C Ojeda-Thies, J Mora-Fernández, A Muñoz-Pascual, J M Cancio, F J Tarazona, T Pareja, P Gómez-Campelo, N Montero-Fernández, T Alarcón, P Mesa-Lampre, R Larrainzar, E Duaso, E Gil-Garay, A Diéz-Pérez, D Prieto-Alhambra, R Queipo-Matas, A Otero-Puime
OBJECTIVE: To ascertain the current situation and clinical variability of the provision of care for Hip Fracture (HF) in Spain and the factors related to it by using a National Registry (NHFR) with high patient numbers and territorial representation NHFR, and to compare results on a national and international level and propose standards and criteria to improve healthcare quality. DESIGN: Continuous registry for at least three years of a representative sample of patients admitted to Spanish hospitals due to HF using the Minimum Common Dataset - international Fragility Fracture Network (FFN) MCD, adapted for Spanish...
February 6, 2018: Revista Española de Geriatría y Gerontología
https://www.readbyqxmd.com/read/29391455/accuracy-of-fetal-fibronectin-for-the-prediction-of-preterm-birth-in-symptomatic-twin-pregnancies-a-pilot-study
#4
Florent Fuchs, Clémentine Lefevre, Marie-Victoire Senat, Hervé Fernandez
Our goal was to evaluate the performance of fetal fibronectin (fFN) test alone or combined with cervical length (CL), to predict spontaneous preterm birth (PTB) in symptomatic twin pregnancies. We carry out a short pilot study including all uncomplicated diamniotic twin pregnancies with symptoms of preterm labor (PTL) and intact membranes at 24-33 weeks + 6 days of gestation. Studied outcome were spontaneous delivery within 7 and 14 days of testing and spontaneous PTB at <34 and <37 weeks of gestation...
February 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29367099/mid-gestational-changes-in-cervicovaginal-fluid-cytokine-levels-in-asymptomatic-pregnant-women-are-predictive-markers-of-inflammation-associated-spontaneous-preterm-birth
#5
Emmanuel Amabebe, David R Chapman, Victoria L Stern, Graham Stafford, Dilly O C Anumba
OBJECTIVES: Perturbation of the choriodecidual space before the onset of spontaneous preterm birth (sPTB) could lead to a concomitant rise in both cervicovaginal fluid (CVF) cytokine and fetal fibronectin (FFN), and assessing the concentrations of both markers could improve the prediction of sPTB (delivery before 37 completed weeks of gestation). Therefore, we prospectively determined mid-trimester changes in CVF cytokine and FFN concentrations, and their predictive capacity for sPTB in asymptomatic pregnant women...
January 10, 2018: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29355887/accuracy-of-fetal-fibronectin-for-assessing-preterm-birth-risk-in-asymptomatic-pregnant-women-a-systematic-review-and-meta-analysis
#6
REVIEW
Francois Dos Santos, Jahnavi Daru, Ewelina Rogozińska, Natalie A M Cooper
INTRODUCTION: Fetal fibronectin (fFN) is a validated test for assessing risk of preterm birth for women presenting with symptoms. Our aim was to evaluate the accuracy of fFN to detect the risk of preterm birth in asymptomatic women. MATERIAL AND METHODS: Searches were conducted to identify studies where fFN was performed in asymptomatic women beyond 22 weeks' gestation. EMBASE, MEDLINE, CINHAL, AMED and BNI were searched between 2005 and 2017. Studies before 2005 were identified from a published systematic review...
January 21, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29297659/fetal-fibronectin-testing-and-pregnancy-outcomes-among-texas-medicaid-patients-at-risk-for-preterm-birth
#7
Jamie C Barner, Allison A Petrilla, Hyeun Ah Kang, Xian Shen, Ahmed M Alshehri, Erin M Sullivan, Kathleen A Troeger, Kristin M Richards, Sean C Blackwell
OBJECTIVES: Fetal fibronectin (fFN) testing between the 24th and 34th weeks of pregnancy in patients with symptomatic preterm labor (PTL) helps assess the risk of spontaneous preterm birth (sPTB), yet the extent of its use is unknown. We assessed use of fFN testing among Texas Medicaid enrollees with symptomatic PTL and evaluated time to infant delivery and healthcare utilization/costs. STUDY DESIGN: Retrospective cohort study using medical and pharmacy claims for Texas Medicaid enrollees...
December 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/29297658/current-perspectives-on-the-use-of-fetal-fibronectin-testing-in-preterm-labor-diagnosis-and-management
#8
Michael S Ruma, Katie C Bittner, Clara B Soh
One in 10 infants in the United States is delivered preterm (ie, before the 37th week of pregnancy), contributing to the significant burden on the national healthcare system. Nevertheless, a lack of agreement continues among obstetric professional societies on guidelines for standardization of the approach to the diagnosis and management of patients with symptoms of preterm labor (PTL). This disparity in consensus has likely resulted in poor identification of women at an increased risk for preterm birth (PTB)...
December 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/29281252/toward-serotonin-fluorescent-false-neurotransmitters-development-of-fluorescent-dual-serotonin-and-vesicular-monoamine-transporter-substrates-for-visualizing-serotonin-neurons
#9
Adam Henke, Yekaterina Kovalyova, Matthew Dunn, Dominik Dreier, Niko G Gubernator, Iva Dincheva, Christopher Hwu, Peter Šebej, Mark S Ansorge, David Sulzer, Dalibor Sames
Ongoing efforts in our laboratories focus on design of optical reporters known as fluorescent false neurotransmitters (FFNs) that enable the visualization of uptake into, packaging within, and release from individual monoaminergic neurons and presynaptic sites in the brain. Here, we introduce the molecular probe FFN246 as an expansion of the FFN platform to the serotonergic system. Combining the acridone fluorophore with the ethylamine recognition element of serotonin, we identified FFN54 and FFN246 as substrates for both the serotonin transporter and the vesicular monoamine transporter 2 (VMAT2)...
February 2, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29275278/increasing-compliance-with-a-clinical-practice-guideline-for-fetal-fibronectin-testing-and-the-management-of-threatened-preterm-labour-a-quality-improvement-project
#10
Lisa K Dawes, Malini Subramoney, Laura M Miller, Katie M Groom
OBJECTIVE: To increase adherence to a local hospital clinical practice guideline for the use of fetal fibronectin testing in women presenting with symptoms of threatened preterm labour. STUDY DESIGN: A quality improvement project using a multi-faceted implementation strategy. SETTING: National Women's Health, Auckland City Hospital; a tertiary referral maternity unit in Auckland, New Zealand. POPULATION: All obstetricians, junior obstetric doctors and hospital employed midwives...
February 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29183020/clinical-application-of-quantitative-foetal-fibronectin-for-the-prediction-of-preterm-birth-in-symptomatic-women
#11
Samara K Radford, Fabricio Da Silva Costa, Edward Araujo Júnior, Penelope M Sheehan
AIM: To evaluate the clinical application of the new Hologic quantitative foetal fibronectin (qfFN) bedside test for the prediction of spontaneous preterm birth (sPTB) in patients with symptoms suggestive of spontaneous threatened preterm labour (sPTL). METHODS: A prospective observational study with 154 pregnant women presenting signs and symptoms of sPTL was conducted. These women were subjected to a qfFN test between 22 and 35 weeks of gestation For each cut-off threshold, the ability to predict sPTB at within 14 days of conducting the test and <37 weeks was assessed by calculating the positive predictive value (PPV), negative predictive value (NPV), likelihood ratios, odds ratios, sensitivity, and specificity...
November 29, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/29143916/a-real-world-comparison-of-folfirinox-gemcitabine-plus-nab-paclitaxel-and-gemcitabine-in-advanced-pancreatic-cancers
#12
Ying Wang, Pierre Camateros, Winson Y Cheung
PURPOSE: FOLFIRINOX (FFN), nab-paclitaxel plus gemcitabine (GN), and gemcitabine are three systemic therapies that provide clinically meaningful benefit to patients with unresectable pancreatic cancer (UPC). There are no clinical trials that directly compare the efficacy of all three regimens. In this study, we aim to examine and compare the real-world effectiveness of these treatments. METHODS: Patients diagnosed with UPC who initiated palliative chemotherapy from August 2014 to January 2016 at any one of six cancer centers in British Columbia were identified from the provincial pharmacy...
November 16, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29042802/utilization-of-fetal-fibronectin-testing-and-pregnancy-outcomes-among-women-with-symptoms-of-preterm-labor
#13
Sean C Blackwell, Erin M Sullivan, Allison A Petrilla, Xian Shen, Kathleen A Troeger, James D Byrne
OBJECTIVES: To identify pregnant health plan members triaged through the emergency department (ED), including labor and delivery (ELD) units, with symptoms of preterm labor (PTL), and evaluate the use of fetal fibronectin (fFN) testing; and to calculate the rate of hospitalization and timing of delivery in relation to the ED visit. METHODS: Retrospective cohort study using Medical Outcomes Research for Effectiveness and Economics Registry® , a national multipayer claims database...
2017: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/28891000/clinical-application-of-modified-bag-of-features-coupled-with-hybrid-neural-based-classifier-in-dengue-fever-classification-using-gene-expression-data
#14
Sankhadeep Chatterjee, Nilanjan Dey, Fuqian Shi, Amira S Ashour, Simon James Fong, Soumya Sen
Dengue fever detection and classification have a vital role due to the recent outbreaks of different kinds of dengue fever. Recently, the advancement in the microarray technology can be employed for such classification process. Several studies have established that the gene selection phase takes a significant role in the classifier performance. Subsequently, the current study focused on detecting two different variations, namely, dengue fever (DF) and dengue hemorrhagic fever (DHF). A modified bag-of-features method has been proposed to select the most promising genes in the classification process...
September 11, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/28747164/use-of-cervicovaginal-pamg-1-protein-as-a-predictor-of-delivery-within-seven-days-in-pregnancies-at-risk-of-premature-birth
#15
Yasemin Çekmez, Gürkan Kıran, Esra Tuştaş Haberal, Merve Dizdar
BACKGROUND: To investigate the utility of vaginal placental alpha microglobulin-1 (PAMG-1) protein as a predictor of preterm delivery within 7 days in pregnancies at risk of premature birth. METHODS: This prospective study was performed in women at risk of premature birth. The levels of vaginal PAMG-1 and foetal fibronectin (fFN) and the transvaginal cervical length measurement (CLM) were investigated and compared. RESULTS: Seventy-two pregnant women were included in this study...
July 26, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28681677/improved-outcome-after-hip-fracture-surgery-in-norway
#16
Jan-Erik Gjertsen, Eva Dybvik, Ove Furnes, Jonas M Fevang, Leif I Havelin, Kjell Matre, Lars B Engesæter
Background and purpose - The operative treatment of hip fractures in Norway has changed considerably during the last decade. We used data in the Norwegian Hip Fracture Register to investigate possible effects of these changes on reoperations and 1-year mortality. Patients and methods - 72,741 femoral neck (FFN) fractures and trochanteric fractures in patients 60 years or older were analyzed. The fractures were divided into 5 time periods (2005-2006, 2007-2008, 2009-2010, 2011-2012, 2013-2014). Cox regression models were used to calculate unadjusted and adjusted (age group, sex, and ASA class) relative risks (RRs) of reoperation and of 1-year mortality in the different time periods...
October 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/28651447/the-association-between-fetal-fibronectin-and-spontaneous-preterm-birth-in-twin-pregnancies-with-a-shortened-cervical-length
#17
Kathy C Matthews, Simi Gupta, Jennifer Lam-Rachlin, Daniel H Saltzman, Andrei Rebarber, Nathan S Fox
OBJECTIVE: To estimate the association between a positive fetal fibronectin (fFN) and spontaneous preterm birth (SPTB) in twin pregnancies with a shortened cervical length (CL). STUDY DESIGN: Retrospective cohort study of asymptomatic twin pregnancies managed by a single MFM practice from 2005 to 2016. We included all women with a shortened CL ≤25 mm at 22-28 weeks, and compared outcomes between women with a positive and negative fFN result. RESULTS: One hundred fifty-five patients were included, 129 (83...
July 10, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28606497/validity-of-a-commercial-wearable-sleep-tracker-in-adult-insomnia-disorder-patients-and-good-sleepers
#18
Seung-Gul Kang, Jae Myeong Kang, Kwang-Pil Ko, Seon-Cheol Park, Sara Mariani, Jia Weng
OBJECTIVES: To compare the accuracy of the commercial Fitbit Flex device (FF) with polysomnography (PSG; the gold-standard method) in insomnia disorder patients and good sleepers. METHODS: Participants wore an FF and actigraph while undergoing overnight PSG. Primary outcomes were intraclass correlation coefficients (ICCs) of the total sleep time (TST) and sleep efficiency (SE), and the frequency of clinically acceptable agreement between the FF in normal mode (FFN) and PSG...
June 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28535404/placental-inflammation-and-its-relationship-to-cervicovaginal-fetal-fibronectin-in-preterm-birth
#19
Laura van der Krogt, Alexandra E Ridout, Paul T Seed, Andrew H Shennan
OBJECTIVE: Late miscarriage and preterm birth are frequently thought to be associated with inflammation and infection, although in most cases the underlying cause of early delivery remains unknown. The placenta is the organ that links mother and fetus during pregnancy, and postnatal examination may provide useful information about pathophysiology. The relationship between placental pathological lesions and predictive markers of early delivery has not been explored. We sought to characterize preterm deliveries according to placental pathology and relate these to the performance of reliable predictive markers, fetal fibronectin and cervical length...
July 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28370518/cost-effectiveness-of-diagnostic-testing-strategies-including-cervical-length-measurement-and-fibronectin-testing-in-women-with-symptoms-of-preterm-labor
#20
Gert-Jan van Baaren, Jolande Y Vis, Femke F Wilms, Martijn A Oudijk, Anneke Kwee, Martina M Porath, Hubertina Cj Scheepers, Marc Ea Spaanderman, Kitty Wm Bloemenkamp, Monique C Haak, Caroline J Bax, Jérôme Mj Cornette, Johannes J Duvekot, Bas Wa Nij Bijvanck, Jim van Eyck, Maureen Tm Franssen, Krystyna M Sollie, Frank Pha Vandenbussche, Mallory Woiski, Antoinette C Bolte, Joris Am van der Post, Patrick Mm Bossuyt, Brent C Opmeer, Ben Wj Mol
OBJECTIVE: To evaluate the cost-effectiveness of combining cervical length (CL) measurement and fetal fibronectin (fFN) tests for women with symptoms of preterm labor between 24 and 34 weeks gestation. METHODS: We performed a model-based cost-effectiveness analysis to evaluate seven test-treatment strategies based on CL and/or fFN in women with symptoms of preterm labor from a societal perspective, in which we weighted neonatal outcome and costs. Estimates of disease prevalence, test accuracy and costs, were based on two recently performed nationwide cohort studies in The Netherlands...
March 31, 2017: Ultrasound in Obstetrics & Gynecology
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