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https://www.readbyqxmd.com/read/28068184/antimicrobial-susceptibilities-of-flavobacterium-psychrophilum-isolates-from-the-great-lakes-basin-michigan
#1
Danielle Van Vliet, Thomas P Loch, Peter Smith, Mohamed Faisal
Flavobacterium psychrophilum is a serious pathogen of salmonids worldwide, a matter that is compounded by the lack of effective vaccine preparations. As a result, biosecurity measures and antimicrobial agents remain the only available methods to control diseases caused by F. psychrophilum. It is feared that antimicrobial use may have led to the development of F. psychrophilum strains with reduced susceptibility. Therefore, the primary objective of this study was to determine the antimicrobial susceptibility profiles of 50 F...
January 9, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/27938689/quantifying-the-effect-of-lactogenic-antibody-on-porcine-epidemic-diarrhea-virus-infection-in-neonatal-piglets
#2
Korakrit Poonsuk, Jianqiang Zhang, Qi Chen, Wendy Gonzalez, Lucas Correa da Silva Carrion, Yaxuan Sun, Ju Ji, Chong Wang, Rodger Main, Jeffrey Zimmerman, Luis Giménez-Lirola
The contribution of lactogenic antibody to the protection of piglets against porcine epidemic diarrhea virus (PEDV) was evaluated. Pregnant multiparous sows and their litters were allocated to one of 3 treatment groups: Group 1-6 serum antibody-negative sows and a subset (n=11) of their piglets. Group 2-8 serum antibody-positive sows and their 91 piglets. Piglets were orally inoculated with PEDV at 4 (Group 1) or 2 (Group 2) days of age. Group 3-2 PEDV serum antibody-negative sows and 22 piglets, provided a baseline for piglet survivability and growth rate...
December 25, 2016: Veterinary Microbiology
https://www.readbyqxmd.com/read/27918947/the-effect-of-blood-staining-on-cervicovaginal-quantitative-fetal-fibronectin-concentration-and-prediction-of-spontaneous-preterm-birth
#3
Natasha L Hezelgrave, Katy Kuhrt, Kate Cottam, Paul T Seed, Rachel M Tribe, Andrew H Shennan
OBJECTIVE: Spontaneous preterm birth is the leading cause of neonatal morbidity and mortality. Cervicovaginal fetal fibronectin (fFN) has enhanced prediction of preterm birth and, more recently, quantified results have become available so that management can planned more effectively and targeted to individual women. Manufacture guidelines stipulate that fetal fibronectin (fFN) samples should be discarded in the presence of moderate to heavy vaginal bleeding but there hasn't yet been any formal investigation into the effect of blood staining on fetal fibronectin concentration and subsequent preterm birth prediction...
January 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27896467/audit-of-geriatric-hip-fracture-care-a%C3%A2-slovenian-trauma-center-analysis
#4
Dejan Krušič, Drago Brilej, Colin Currie, Radko Komadina
BACKGROUND: The aim was to describe an audit of hip fracture patient care and outcomes in a Slovenian healthcare setting prior to the implementation of the Geriatric Fracture Center (GFC) model of care. METHODS: The Fragility Fracture Network (FFN) hip fracture audit database was used to collect data on hip fracture care in elderly patients. Epidemiological data were submitted as well as fracture type, prefracture residence and mobility prior to the fracture. The timeline of events and acute care data were also collected...
December 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/27777928/cervicovaginal-fluid-acetate-a-metabolite-marker-of-preterm-birth-in-symptomatic-pregnant-women
#5
Emmanuel Amabebe, Steven Reynolds, Victoria Stern, Graham Stafford, Martyn Paley, Dilly O C Anumba
Changes in vaginal microbiota that is associated with preterm birth (PTB) leave specific metabolite fingerprints that can be detected in the cervicovaginal fluid (CVF) using metabolomics techniques. In this study, we characterize and validate the CVF metabolite profile of pregnant women presenting with symptoms of threatened preterm labor (PTL) by both (1)H-nuclear magnetic resonance spectroscopy (NMR) and enzyme-based spectrophotometry. We also determine their predictive capacity for PTB, singly, and in combination, with current clinical screening tools - cervicovaginal fetal fibronectin (FFN) and ultrasound cervical length (CL)...
2016: Frontiers in Medicine
https://www.readbyqxmd.com/read/27750180/comparison-of-the-actim-partus-test-and-the-fetal-fibronectin-test-in-the-prediction-of-spontaneous-preterm-birth-in-symptomatic-women-undergoing-cervical-length-measurement
#6
Merel M C Bruijn, Jolande Y Vis, Femke F Wilms, Martijn A Oudijk, Anneke Kwee, Martina M Porath, Guid Oei, Hubertina C J Scheepers, Marc E A Spaanderman, Kitty W M Bloemenkamp, Monique C Haak, Antoinette C Bolte, Frank P H A Vandenbussche, Mallory D Woiski, Caroline J Bax, Jérôme M J Cornette, Johannes J Duvekot, Bas W A Nij Bijvank, Jim van Eyck, Maureen T M Franssen, Krystyna M Sollie, Joris A M van der Post, Patrick M M Bossuyt, Brent C Opmeer, M Kok, Ben W J Mol, Gert-Jan van Baaren
OBJECTIVE: To compare the accuracy of the Actim Partus test and fetal fibronectin (fFN) test in the prediction of spontaneous preterm delivery within seven days in symptomatic women undergoing cervical length measurement. STUDY DESIGN: We performed a post-hoc analysis on frozen samples of a nationwide cohort study in all 10 perinatal centres in the Netherlands. We selected samples from women with signs of preterm labour between 24 and 34 weeks of gestational age and a cervical length below 30mm...
November 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27591351/post-policy-implementation-review-of-rapid-fetal-fibronectin-ffn-testing-for-preterm-labour-in-alberta
#7
Anderson W Chuck, Nguyen X Thanh, Radha S Chari, Robert Douglas Wilson, Selikke Janes-Kelley, James C Wesenberg
OBJECTIVES: In 2006, the Alberta Ministry of Health issued a policy to implement fetal fibronectin (fFN) testing as a publicly funded service for pregnant women. The goals were to reduce maternity health care utilization and unnecessary treatment, which would result in cost-savings for the health system by more accurately diagnosing false preterm labour. We conducted a post-policy implementation review to determine whether the policy implementation achieved its goals. METHODS: We assessed the impacts of fFN testing on clinical decision-making for ambulance transfer, hospital admission, and length of hospital stay by comparing these variables between the tested and untested patients...
July 2016: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/27590604/a-critical-review-of-the-long-term-disability-outcomes-following-hip-fracture
#8
Suzanne M Dyer, Maria Crotty, Nicola Fairhall, Jay Magaziner, Lauren A Beaupre, Ian D Cameron, Catherine Sherrington
BACKGROUND: Hip fractures are an increasingly common consequence of falls in older people that are associated with a high risk of death and reduced function. This review aims to quantify the impact of hip fracture on older people's abilities and quality of life over the long term. METHODS: Studies were identified through PubMed and Scopus searches and contact with experts. Cohort studies of hip fracture patients reporting outcomes 3 months post-fracture or longer were included for review...
September 2, 2016: BMC Geriatrics
https://www.readbyqxmd.com/read/27499740/effects-of-calcium-spikes-in-the-layer-5-pyramidal-neuron-on-coincidence-detection-and-activity-propagation
#9
Yansong Chua, Abigail Morrison
The role of dendritic spiking mechanisms in neural processing is so far poorly understood. To investigate the role of calcium spikes in the functional properties of the single neuron and recurrent networks, we investigated a three compartment neuron model of the layer 5 pyramidal neuron with calcium dynamics in the distal compartment. By performing single neuron simulations with noisy synaptic input and occasional large coincident input at either just the distal compartment or at both somatic and distal compartments, we show that the presence of calcium spikes confers a substantial advantage for coincidence detection in the former case and a lesser advantage in the latter...
2016: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/27441567/which-factors-contribute-to-false-positive-false-negative-and-invalid-results-in-fetal-fibronectin-testing-in-women-with-symptoms-of-preterm-labor
#10
Merel M C Bruijn, Frederik J R Hermans, Jolande Y Vis, Femke F Wilms, Martijn A Oudijk, Anneke Kwee, Martina M Porath, Guid Oei, Hubertina C J Scheepers, Marc E A Spaanderman, Kitty W M Bloemenkamp, Monique C Haak, Antoinette C Bolte, Frank P H A Vandenbussche, Mallory D Woiski, Caroline J Bax, Jérôme M J Cornette, Johannes J Duvekot, Bas W A N I J Bijvank, Jim van Eyck, Maureen T M Franssen, Krystyna M Sollie, Joris A M van der Post, Patrick M M Bossuyt, Marjolein Kok, Ben W J Mol, Gert-Jan van Baaren
Objective We assessed the influence of external factors on false-positive, false-negative, and invalid fibronectin results in the prediction of spontaneous delivery within 7 days. Methods We studied symptomatic women between 24 and 34 weeks' gestational age. We performed uni- and multivariable logistic regression to estimate the effect of external factors (vaginal soap, digital examination, transvaginal sonography, sexual intercourse, vaginal bleeding) on the risk of false-positive, false-negative, and invalid results, using spontaneous delivery within 7 days as the outcome...
July 21, 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27434692/the-independent-association-of-a-short-cervix-positive-fetal-fibronectin-amniotic-fluid-sludge-and-cervical-funneling-with-spontaneous-preterm-birth-in-twin-pregnancies
#11
Jessica Spiegelman, Whitney Booker, Simi Gupta, Jennifer Lam-Rochlin, Andrei Rebarber, Daniel H Saltzman, Ana Monteagudo, Nathan S Fox
Objective To estimate the independent association of a short cervical length (CL), positive fetal fibronectin (fFN), amniotic fluid (AF) sludge, and cervical funneling with spontaneous preterm birth in twin pregnancies. Methods Retrospective cohort study of twin pregnancies managed by a single maternal-fetal medicine practice from June 2005 to February 2014. All patients underwent transvaginal sonographic CL and fFN testing. We reviewed all images from the first CL at 22(0/7) to 25(6/7) weeks for the presence of (1) a short CL, which is defined as ≤25 mm, (2) AF sludge, and (3) cervical funneling, and also recorded (4) the fFN result from that time...
October 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27388033/comparison-of-rapid-bedside-tests-for-phosphorylated-insulin-like-growth-factor-binding-protein-1-and-fetal-fibronectin-to-predict-preterm-birth
#12
Reva Tripathi, Shakun Tyagi, Yedla M Mala, Nilanchali Singh, Nalini B Pandey, Preeti Yadav
OBJECTIVE: To compare the accuracy of rapid bedside tests for phosphorylated insulin-like growth factor-binding protein 1 (phIGFBP-1) and fetal fibronectin (fFN) to predict preterm delivery among women with threatened preterm labor. METHODS: A prospective observational study was conducted among women with a singleton pregnancy of 28-36 weeks, intact membranes, and symptoms suggestive of preterm labor who attended a center in New Delhi, India, between April 1, 2011, and March 31, 2014...
October 2016: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/27299902/a-comprehensive-fracture-prevention-strategy-in-older-adults-the-european-union-geriatric-medicine-society-eugms-statement
#13
H Blain, T Masud, P Dargent-Molina, F C Martin, E Rosendahl, N van der Velde, J Bousquet, A Benetos, C Cooper, J A Kanis, J Y Reginster, R Rizzoli, B Cortet, M Barbagallo, K E Dreinhöfer, B Vellas, S Maggi, T Strandberg
Prevention of fragility fractures in older people has become a public health priority, although the most appropriate and cost-effective strategy remains unclear. In the present statement, the Interest Group on Falls and Fracture Prevention of the European Union Geriatric Medicine Society, in collaboration with the International Association of Gerontology and Geriatrics for the European Region, the European Union of Medical Specialists, and the International Osteoporosis Foundation-European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis, outlines its views on the main points in the current debate in relation to the primary and secondary prevention of falls, the diagnosis and treatment of bone fragility, and the place of combined falls and fracture liaison services for fracture prevention in older people...
August 2016: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/27280542/quantitative-fetal-fibronectin-predicts-preterm-birth-in-women-with-bulging-fetal-membranes
#14
Francesco Fiorini, Alexander Isted, Natasha L Hezelgrave, Andrew H Shennan
OBJECTIVE: To assess the predictive value of quantitative fetal fibronectin (fFN) concentration in cervicovaginal fluid for spontaneous preterm birth in women with bulging fetal membranes. STUDY DESIGN: This was a prospective observational study from five UK tertiary centres of a cohort of women with singleton pregnancy and bulging fetal membranes presenting between 18 and 32 weeks of gestation (n=62), in the period 2010-2014. fFN concentrations in cervicovaginal fluid were measured both quantitatively and qualitatively at presentation in all women...
August 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27147420/implementation-of-foetal-fibronectin-testing-admissions-maternal-interventions-and-costs-at-1%C3%A2-year
#15
Maryam Parisaei, Jane Currie, Neil O'Gorman, Stephen Morris, Anna L David
Foetal fibronectin testing (fFN) has a high negative predictive value for preterm delivery, but it has a cost implication. This two-stage prospective study evaluated the real patient costs and clinical impact of introducing the fFN test in women presenting acutely with threatened preterm labour in a tertiary UK obstetric hospital. Introduction of the fFN test for women with threatened preterm labour reduced antenatal admissions and in utero transfers, and reduced steroid treatment and tocolysis, even at 1 year after implementation...
October 2016: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27133012/fetal-fibronectin-testing-for-prevention-of-preterm-birth-in-singleton-pregnancies-with-threatened-preterm-labor-a-systematic-review-and-metaanalysis-of-randomized-controlled-trials
#16
REVIEW
Vincenzo Berghella, Gabriele Saccone
OBJECTIVE DATA: Fetal fibronectin is an extracellular matrix glycoprotein that is produced by amniocytes and cytotrophoblasts and has been shown to predict spontaneous preterm birth. STUDY: The aim of this systematic review and metaanalysis of randomized clinical trials was to evaluate the effect of the use of fetal fibronectin in the prevention of preterm birth in singleton pregnancies with threatened preterm labor. STUDY APPRAISAL AND SYNTHESIS METHODS: The research was conducted with the use of MEDLINE, EMBASE, Web of Sciences, Scopus, ClinicalTrial...
October 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27107832/influence-of-transvaginal-ultrasound-examination-on-quantitative-vaginal-fibronectin-measurements-a-prospective-evaluation-study
#17
Michaela Golic, Jan-Peter Siedentopf, Franziska Pauly, Larry Hinkson, Wolfgang Henrich, Elisabeth Tucher
OBJECTIVE: The most important parameter in prediction of preterm birth is the cervical length measured by transvaginal ultrasound. In cases with mid-range cervical length (10-30 mm), prediction of preterm birth is difficult. In these cases, testing for cervicovaginal fluid fetal fibronectin (fFN) can improve prediction. However, it is unclear whether transvaginal ultrasound itself influences the fFN result. The purpose of this study was to evaluate this issue independent of gestational age and cervical length...
January 1, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/27052846/prediction-of-preterm-delivery-by-fetal-fibronectin-in-symptomatic-and-asymptomatic-women-with-cervical-length-%C3%A2-20%C3%A2-mm
#18
Elena Magro-Malosso, Viola Seravalli, Mauro Cozzolino, Marina Spitaleri, Tommaso Susini, Mariarosaria Di Tommaso
OBJECTIVE: To evaluate the diagnostic accuracy of cervicovaginal fetal fibronectin (fFN) in predicting preterm delivery (PTD) in symptomatic and asymptomatic women with cervical length (CL) ≤ 20 mm. METHODS: A retrospective cohort study on pregnant singleton women admitted for CL ≤ 20 mm, with or without uterine contractions, between 22 and 34 weeks. For each group, symptomatic and asymptomatic, the following outcomes were evaluated: PTD before 37 and 34 weeks, delivery within 48 h, 7, 14 and 21 days after fibronectin sampling...
February 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27049613/evaluation-of-quantitative-ffn-test-in-predicting-the-risk-of-preterm-birth
#19
Michela Centra, Giuliana Coata, Elena Picchiassi, Luisa Alfonsi, Samanta Meniconi, Vittorio Bini, Maria Rosaria Di Tommaso, Mauro Cozzolino, Fabio Facchinetti, Francesca Ferrari, Maria Teresa Gervasi, Silvia Rusconi, Tullia Todros, Valentina Frisina, Nicola Rizzo, Maria Bisulli, Gian Carlo Di Renzo
OBJECTIVE: To evaluate diagnostic accuracy of quantitative fetal fibronectin (qfFN) test in predicting preterm birth (PTB) risk <34 weeks' gestation or within 14 days from testing. We explored the predictive potential of the test in five-predefined PTB risk categories based on predefined qfFN thresholds (<10, 10-49, 50-199, 200-499 and ≥500 ng/mL). METHODS: Measurement of cervicovaginal qfFN with Rapid fFN 10Q System (Hologic) in 126 women with singleton pregnancy (23-33 weeks' gestation) reporting signs and symptoms indicative of preterm labour (PTL)...
January 1, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/27048042/combination-of-selected-biochemical-markers-and-cervical-length-in-the-prediction-of-impending-preterm-delivery-in-symptomatic-patients
#20
M Hadži-Legal, A Daneva Markova, M Stefanovic, M Tanturovski
The pathophysiology of preterm delivery (PTD) is complex and multifactorial.It occurs in 8-12% of all deliveries, and the rate of PTD has increased during the past years in spite of intensive efforts towards early detection and prompt treatment. Fifty-eight pregnant women were eligible to join the study if they attended the University Clinic for Gynecology and Obstetrics, Skopje and were admitted to Department of High Risk pregnancy Unit with symptoms of preterm labor (PTL) (symptoms of uterine activity judged by the assessing physician to be indicative of PTL) at 24...
2016: Clinical and Experimental Obstetrics & Gynecology
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