keyword
MENU ▼
Read by QxMD icon Read
search

TDT

keyword
https://www.readbyqxmd.com/read/28936820/-efficacy-of-low-dose-aripiprazole-to-treat-clozapine-associated-tardive-dystonia-in-a-patient-with-schizophrenia
#1
Lyang Huh, Bong Ju Lee
Tardive dystonia (TDt) is a debilitating side effect of long-term antipsychotic treatment. Even though TDt is associated with increased psychiatric morbidity, mortality, and severely decreased quality of life, there are no treatment modalities for TDt. Clozapine has been used as a treatment option for TDt in patients with schizophrenia. Interestingly, several recent case reports have indicated that it can enhance or induce TDt. We report a case of clozapine-associated TDt that was treated with low-dose aripiprazole (0...
2017: Türk Psikiyatri Dergisi, Turkish Journal of Psychiatry
https://www.readbyqxmd.com/read/28936504/single-quantum-dot-based-nanosensor-for-rapid-and-sensitive-detection-of-terminal-deoxynucleotidyl-transferase
#2
Li-Juan Wang, Ming-Li Luo, Qianyi Zhang, Bo Tang, Chun-Yang Zhang
We developed a simple and rapid method for terminal deoxynucleotidyl transferase (TdT) assay on the basis of the polymerization-directed exonuclease-assisted construction of a single quantum dot (QD)-based fluorescence resonance energy transfer (FRET) nanosensor. This method is very sensitive with a detection limit as low as 1 × 10(-6) U μL(-1), and it can be used for the screening of TDT inhibitors and accurate quantification of TdT activity even in 5 cancer cells.
September 22, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28928948/virtual-screening-workflow-tutorials-and-prospective-results-from-the-teach-discover-treat-competition-2014-against-malaria
#3
Sereina Riniker, Gregory A Landrum, Floriane Montanari, Santiago D Villalba, Julie Maier, Johanna M Jansen, W Patrick Walters, Anang A Shelat
The first challenge in the 2014 competition launched by the Teach-Discover-Treat (TDT) initiative asked for the development of a tutorial for ligand-based virtual screening, based on data from a primary phenotypic high-throughput screen (HTS) against malaria. The resulting Workflows were applied to select compounds from a commercial database, and a subset of those were purchased and tested experimentally for anti-malaria activity. Here, we present the two most successful Workflows, both using machine-learning approaches, and report the results for the 114 compounds tested in the follow-up screen...
2017: F1000Research
https://www.readbyqxmd.com/read/28928100/effects-of-alfentanil-or-fentanyl-added-to-propofol-for-sedation-in-colonoscopy-on-cognitive-functions-randomized-controlled-trial
#4
Güler Doğanay, Perihan Ekmekçi, Baturay Kansu Kazbek, Hakan Yılmaz, Gülbanu Erkan, Filiz Tüzüner
BACKGROUND/AIMS: To assess the effect of propofol supplemented with alfentanil or fentanyl on cognitive functions for sedation during elective colonoscopy. MATERIALS AND METHODS: Patients (n=150, 18-65 years old, American Society of Anesthesiologists risk group I-III) scheduled undergo elective colonoscopy were included. They were randomized into three groups using the closed envelope methodpropofol-alfentanil (Group A), propofol-fentanyl (Group F), and propofol only (Group P)...
September 19, 2017: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/28920521/implementing-evidence-based-smoking-cessation-treatment-in-psychosocial-care-units-caps-in-brazil
#5
João Mauricio Castaldelli-Maia, Nilson R da Silva, Marta Rd Campos, Helena F Moura, Gustavo Zabert, Beatriz M Champagne, Katherine E Kemper, J Taylor Hays
BACKGROUND: The prevalence of smoking among mental health and addiction (MHA) patients is 3 times higher than it is in the general population, yet this patient population has received little help to combat smoking. Considering this, psychosocial care centers (CAPS - Centros de Atenção Psicossocial) are strategic locations for integrating tobacco dependence treatment (TDT) into existing treatment activities. METHODS: Our team provided an 8-hour training package to the staff of CAPS that have not been providing specialized TDT for smokers...
September 1, 2017: International Journal of Social Psychiatry
https://www.readbyqxmd.com/read/28899959/impaired-malate-and-fumarate-accumulation-due-the-mutation-of-tonoplast-dicarboxylate-transporter
#6
David B Medeiros, Kallyne Barros, Jessica As Barros, Rebeca P Omena-Garcia, Stéphanie Arrivault, Lilian Vincis Pereira Sanglard, Kelly C Detmann, Willian Batista Silva, Danilo M Daloso, Fabio DaMatta, Adriano Nunes-Nesi, Alisdair R Fernie, Wagner L Araújo
Malate is a central metabolite involved in a multiplicity of plant metabolic pathways, being associated with mitochondrial metabolism and playing significant roles in stomatal movements. Vacuolar malate transport has been characterized at the molecular level and is performed by at least one carrier protein and two channels in Arabidopsis vacuoles. The absence of the Arabidopsis thaliana tonoplast Dicarboxylate Transporter (tDT) in tdt knockout mutant was previously associated with an impaired accumulation of malate and fumarate in leaves...
September 12, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28894083/ataxia-telangiectasia-mutated-atm-protein-signaling-participates-in-development-of-pulmonary-arterial-hypertension-in-rats
#7
Fan Hu, Caijun Liu, Hanmin Liu, Liang Xie, Li Yu
BACKGROUND Previous studies revealed physiological and pathogenetic similarity between vascular smooth muscles cells with severe pulmonary arterial hypertension and tumors. The DNA damage response was found in both pulmonary arterial hypertension (PAH) cells and tumors. The ataxia-telangiectasia mutated proteins (ATM) pathway is considered an important factor in the DNA damage response of tumor formation, but its function in the development of PAH remains unknown. MATERIAL AND METHODS The Sprague-Dawley rat PAH model was established...
September 12, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28884221/evaluation-of-the-greek-tranqol-a-novel-questionnaire-for-measuring-quality-of-life-in-transfusion-dependent-thalassemia-patients
#8
Philippos Klonizakis, Robert Klaassen, Nikolaos Sousos, Aris Liakos, Apostolos Tsapas, Efthymia Vlachaki
The aim of our study was to evaluate the Greek version of the transfusion-dependent quality of life (TranQol) questionnaire and report our experience of using this novel disease-specific quality of life (QoL) measure in patients with transfusion-dependent thalassemia (TDT). The TranQol and SF-36v2 questionnaires were administered to 94 adult TDT patients with a mean age of 32.1 years (SD = 7, range = 19-58), recruited from the Adult Thalassemia Unit of Hippokration General Hospital of Thessaloniki, Greece...
September 7, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28884033/high-grade-b-cell-neoplasm-with-surface-light-chain-restriction-and-tdt-coexpression-evolved-in-a-myc-rearranged-diffuse-large-b-cell-lymphoma-a-dilemma-in-classification
#9
Dina Sameh Soliman, Ahmad Al-Sabbagh, Feryal Ibrahim, Ruba Y Taha, Zafar Nawaz, Sarah Elkourashy, Abdulrazzaq Haider, Susanna Akiki, Mohamed Yassin
According to World Health Organization (WHO) classification (2008), B-cell neoplasms are classified into precursor B-cell or a mature B-cell phenotype and this classification was also kept in the latest WHO revision (2016). We are reporting a male patient in his fifties, with tonsillar swelling diagnosed as diffuse large B-cell lymphoma (DLBCL), germinal center. He received 6 cycles of RCHOP and showed complete metabolic response. Two months later, he presented with severe CNS symptoms. Flow cytometry on bone marrow (BM) showed infiltration by CD10-positive Kappa-restricted B-cells with loss of CD20 and CD19, and downregulation of CD79b...
2017: Case Reports in Hematology
https://www.readbyqxmd.com/read/28875336/progression-of-liver-fibrosis-can-be-controlled-by-adequate-chelation-in-transfusion-dependent-thalassemia-tdt
#10
D Maira, E Cassinerio, A Marcon, M Mancarella, M Fraquelli, P Pedrotti, M D Cappellini
A substantial proportion of patients with transfusion-dependent beta-thalassemia major suffer from chronic liver disease. Iron overload resulting from repeated transfusions and HCV infection has been implicated in the development of liver fibrosis. Hepatic siderosis and fibrosis were assessed in 99 transfusion-dependent thalassemia (TDT) patients using transient elastography (TE) and liver iron concentration (LIC) assessed by T2*MRI at baseline and after 4 years. Data were analyzed retrospectively. At baseline, the overall mean liver stiffness measurement (LSM) was 7...
September 5, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28856695/association-between-body-mass-index-and-sperm-quality-and-sperm-dna-integrity-a-large-population-study
#11
J B A Oliveira, C G Petersen, A L Mauri, L D Vagnini, A Renzi, B Petersen, M Mattila, F Dieamant, R L R Baruffi, J G Franco
This study aimed to analyse whether the functional quality of spermatozoa is associated with body mass index (BMI). Semen samples were obtained from 1824 men undergoing fertility evaluation/treatment. Semen analysis was performed using World Health Organization (WHO) criteria, and morphology was evaluated with the motile sperm organelle morphology examination (MSOME). The percentages of sperm DNA fragmentation (using TdT (terminal deoxynucleotidyl transferase)-mediated dUTP nick-end labelling (TUNEL) assays), sperm chromatin packaging/underprotamination (using chromomycin A3/CMA3 ), mitochondrial damage (using MitoTracker Green) and apoptosis (using annexin V) were also assessed...
August 30, 2017: Andrologia
https://www.readbyqxmd.com/read/28846566/activation-of-pyruvate-dehydrogenase-activity-bydichloroacetate-improves-survival-and-neurologic-outcomes-after-cardiac-arrest-in-rats
#12
Peng Wang, Mingdi Chen, Zhengfei Yang, Tao Yu, Jie Zhu, Lili Zhou, Jiali Lin, Xiangshao Fang, Zitong Huang, Longyuan Jiang, Wanchun Tang
No pharmacological interventions are currently available to provide neuroprotection for patients suffering from cardiac arrest. Dichloroacetate (DCA) is a pyruvate dehydrogenase kinase inhibitor, which activates pyruvate dehydrogenase (PDH), and increases cell adenosine triphosphate (ATP) production by promoting influx of pyruvate into the Krebs cycle. In this study, we investigated the effects of DCA on post-resuscitation neurological injury in an asphyxial cardiac arrest rat model. Asphyxial cardiac arrest was established by endotracheal tube clamping...
August 25, 2017: Shock
https://www.readbyqxmd.com/read/28845698/novel-cd123-aptamer-originated-targeted-drug-trains-for-selectively-delivering-cytotoxic-agent-to-tumor-cells-in-acute-myeloid-leukemia-theranostics
#13
Haibin Wu, Meng Wang, Bo Dai, Yanmin Zhang, Ying Yang, Qiao Li, Mingyue Duan, Xi Zhang, Xiaomei Wang, Anmao Li, Liyu Zhang
Since conventional chemotherapy for acute myeloid leukemia (AML) has its limitations, a theranostic platform with targeted and efficient drug transport is in demand. In this study, we developed the first CD123 (AML tumor marker) aptamers and designed a novel CD123-aptamer-mediated targeted drug train (TDT) with effective, economical, biocompatible and high drug-loading capacity. These two CD123 aptamers (termed as ZW25 and CY30, respectively) can bind to a CD123 peptide epitope and CD123 + AML cells with high specificities and KD of 29...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28844781/comparison-of-efficacies-of-the-self-expandable-metallic-stent-versus-transanal-drainage-tube-and-emergency-surgery-for-malignant-left-sided-colon-obstruction
#14
Jun Kawachi, Hiroyuki Kashiwagi, Rai Shimoyama, Naoko Isogai, Ryuta Fukai, Katsunori Miyake, Hideto Egashira, Ayumu Sugitani, Hidemitsu Ogino
BACKGROUND/OBJECTIVE: Patients with left-sided malignant colorectal obstruction require emergency treatment. Emergency stoma surgery has traditionally been recommended, however many stomas became permanent, decreasing patient quality of life. Recently, self-expandable metallic stents (SEMS) and transanal decompression tubes (TDT) have become widely used decompression methods to avoid stoma surgery. In this study, we evaluated: 1) the efficacy of SEMS compared with TDT and emergency surgery (ES) to avoid permanent stomas; and 2) the safety and success rate of each treatment...
August 24, 2017: Asian Journal of Surgery
https://www.readbyqxmd.com/read/28839382/sugemule-3-protects-against-isoprenaline-induced-cardiotoxicity-in-vitro
#15
Yu Wang, Guo-Hua Gong, Ya-Nan Xu, Li-Jun Yu, Cheng-Xi Wei
BACKGROUND: Sugemule-3 (SD) is a traditional Chinese medicine with protective effect of myocardium. However, the underlying mechanisms of the effect had not been elucidated. MATERIALS AND METHODS: In the present study, the serum of SD was prepared. A model of β-adrenergic agonist isoprenaline (ISO)-induced H9c2 cardiomyocytes injury was established in vitro. The changes in cell viability were examined to determine the available concentration of ISO and serum of SD...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28837057/the-natural-fungal-metabolite-beauvericin-exerts-anticancer-activity-in-vivo-a-pre-clinical-pilot-study
#16
Daniela Heilos, Yelko Rodríguez-Carrasco, Bernhard Englinger, Gerald Timelthaler, Sushilla van Schoonhoven, Michael Sulyok, Simon Boecker, Roderich D Süssmuth, Petra Heffeter, Rosa Lemmens-Gruber, Rita Dornetshuber-Fleiss, Walter Berger
Recently, in vitro anti-cancer properties of beauvericin, a fungal metabolite were shown in various cancer cell lines. In this study, we assessed the specificity of this effect by comparing beauvericin cytotoxicity in malignant versus non-malignant cells. Moreover, we tested in vivo anticancer effects of beauvericin by treating BALB/c and CB-17/SCID mice bearing murine CT-26 or human KB-3-1-grafted tumors, respectively. Tumor size and weight were measured and histological sections were evaluated by Ki-67 and H/E staining as well as TdT-mediated-dUTP-nick-end (TUNEL) labeling...
August 24, 2017: Toxins
https://www.readbyqxmd.com/read/28836108/hyperglycemia-induces-attention-and-gait-deficits-in-diabetic-mellitus-patients
#17
L Sattar, B Renneboog, G Decaux
AIMS: Patients with diabetes mellitus experience a large number of falls and bone fractures that are not related solely to complications of the disease. The purpose of our study was to determine whether transient hyperglycemia affects attentional functions and gait. METHODS: This was a case-control study. We asked 17 patients with type 1 or type 2 diabetes mellitus to perform three visual tests and one visual and auditory attention test (Phasic Alert A1-4 and A2-3, Go/No Go, Intermodal Comparison)...
August 23, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28830823/lack-of-association-between-slc5a7-polymorphisms-and-tourette-syndrome-in-a-chinese-han-population
#18
Wenmiao Liu, Shiyan Qiu, Chuanping Gao, Guiju Wang, Shiguo Liu, Hongzai Guan
Although Tourette syndrome (TS) is a chronic neuropsychiatric disorder whose pathogenesis remains unclear, genetic factors play an important role in the occurrence and development. A variety of studies have been shown that the candidate genes related to cholinergic neurons may be associated with the onset of TS. To investigate the association between the SLC5A7 polymorphisms and Tourette syndrome (TS) in the Chinese Han population, the SNP rs1013940, rs2433718, and rs4676169 were genotyped in 401 TS trios and 400 controls...
August 19, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28829068/a-surface-acoustic-wave-biosensor-synergizing-dna-mediated-in-situ-silver-nanoparticle-growth-for-a-highly-specific-and-signal-amplified-nucleic-acid-assay
#19
Yulin Zhang, Fan Yang, Zhongyue Sun, Yu-Tao Li, Guo-Jun Zhang
This work reports a surface acoustic wave (SAW) DNA sensor that synergizes the surface mass effect for signal-amplified and sequence-specific DNA detection in blood serum. By combining an enzyme-mediated DNA extension reaction (both viscoelastic and mass fractions) with the in situ synthesis of silver nanoparticles (mass fraction), a highly sensitive SAW biosensing interface with synergistic mass loading was tailor-engineered. As target DNA hybridized with the surface-confined capture probes, the exposed 3'-OH terminal of the target sequence could be triggered to elongate in the presence of terminal deoxynucleoside transferase (TdT) and deoxy-ribonucleoside triphosphate (dNTP), thereby producing an evident mass effect...
August 22, 2017: Analyst
https://www.readbyqxmd.com/read/28809055/apoptotic-effect-of-astragalin-in-melanoma-skin-cancers-via-activation-of-caspases-and-inhibition-of-sry-related-hmg-box-gene-10
#20
Ok Heui You, Eun Ah Shin, Hyemin Lee, Ju-Ha Kim, Deok Yong Sim, Jung Hyo Kim, Younghwan Kim, Jae-Ho Khil, Nam-In Baek, Sung-Hoon Kim
Though Astragalin (kaempferol-3-glucoside) contained in Paeonia lactiflora and other plants was known to have anti-oxidant, antiinflammatory, and anti-tumor activity, the anti-tumor mechanism of Astragalin has never been reported in melanomas until now. Thus, in the present study, the underlying apoptotic mechanism of Astragalin isolated from Aceriphyllum rossii was elucidated in A375P and SK-MEL-2 melanoma cells. Astragalin exerted cytotoxicity in A375P and SK-MEL-2 cells in a concentration-dependent manner...
August 15, 2017: Phytotherapy Research: PTR
keyword
keyword
73853
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"