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Coronary CTA

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https://www.readbyqxmd.com/read/28214139/accuracy-of-computed-tomography-angiography-to-identify-thin-cap-fibroatheroma-detected-by-optical-coherence-tomography
#1
Nobuo Tomizawa, Kodai Yamamoto, Shinichi Inoh, Takeshi Nojo, Sunao Nakamura
BACKGROUND: Thin-cap fibroatheroma (TCFA) is assumed to cause acute coronary syndromes. OBJECTIVE: To compare the accuracy of different models for diagnosing TCFA using parameters derived by CT, validated against optical coherence tomography (OCT). METHODS: One hundred twenty-nine plaques in 106 patients were analyzed using data acquired by 64-row CT with a reconstruction thickness of 0.67 mm and an increment of 0.33 mm. TCFA was defined by OCT as a plaque with lipid content in ≥2 quadrants and the thinnest part of the fibrous cap measuring ≤65 μm...
February 9, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28210769/preprocedural-risk-assessment-prior-to-ppvi-with-cmr-and-cardiac-ct
#2
Ladonna Malone, Brian Fonseca, Thomas Fagan, Jane Gralla, Neil Wilson, Micheal DiMaria, Uyen Truong, Lorna P Browne
Percutaneous pulmonary valve intervention (PPVI) is a less invasive and less costly approach to pulmonary valve replacement compared with the surgical alternative. Potential complications of PPVI include coronary compression and pulmonary arterial injury/rupture. The purpose of this study was to characterize the morphological risk factors for PPVI complication with cardiac MRI and cardiac CTA. A retrospective review of 88 PPVI procedures was performed. 44 patients had preprocedural cardiac MRIs or CTAs available for review...
February 16, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28209366/quantifying-aortic-valve-calcification-using-coronary-computed-tomography-angiography
#3
Abdulrahman M Alqahtani, Kevin E Boczar, Vinay Kansal, Kwan Chan, Girish Dwivedi, Benjamin J W Chow
INTRODUCTION: Aortic valve calcification (AVC) has been associated with major adverse cardiovascular events and all-cause mortality. We sought to develop and validate a method to quantify AVC using coronary CT angiography (CTA). METHODS: Of 59 patients who underwent both non-contrast and contrast enhanced coronary CTA, 25 patients served as the derivation cohort and 34 patients served as the validation cohort. For non-contrast enhanced CT, quantification of AVC was performed using the Agatston method for coronary artery calcification (CAC)...
January 30, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28194728/diagnostic-performance-of-the-quantification-of-myocardium-at-risk-from-mpi-spect-cta-2g-fusion-for-detecting-obstructive-coronary-disease-a-multicenter-trial
#4
Marina Piccinelli, Cesar Santana, Gopi Kiran R Sirineni, Russell D Folks, C David Cooke, Chesnal D Arepalli, Santiago Aguade-Bruix, Zohar Keidar, Alex Frenkel, Ora Israel, Jaume Candell-Riera, Ernest V Garcia
BACKGROUND: The effective non-invasive identification of coronary artery disease (CAD) and its proper referral for invasive treatment are still unresolved issues. We evaluated our quantification of myocardium at risk (MAR) from our second generation 3D MPI/CTA fusion framework for the detection and localization of obstructive coronary disease. METHODS: Studies from 48 patients who had rest/stress MPI, CTA, and ICA were analyzed from 3 different institutions. From the CTA, a 3D biventricular surface of the myocardium with superimposed coronaries was extracted and fused to the perfusion distribution...
February 13, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28169175/in%C3%A2-vivo-coronary-lesion-differentiation-with-computed-tomography-angiography-and-intravascular-ultrasound-as-compared-to-optical-coherence-tomography
#5
Wouter G Wieringa, Chris P H Lexis, Erik Lipsic, Hindrik W van der Werf, Johannes G M Burgerhof, Vincent E Hagens, G Louis Bartels, Alexander Broersen, Remco A Schurer, Eng-Shiong Tan, Pim van der Harst, Ad F M van den Heuvel, Tineke P Willems, Gabija Pundziute
BACKGROUND: In vitro studies have shown the feasibility of coronary lesion grading with computed tomography angiography (CTA), intravascular ultrasound (IVUS) and optical coherence tomography (OCT) as compared to histology, whereas OCT had the highest discriminatory capacity. OBJECTIVE: We investigated the ability of CTA and IVUS to differentiate between early and advanced coronary lesions in vivo, OCT serving as standard of reference. METHODS: Multimodality imaging was prospectively performed in 30 NSTEMI patients...
January 22, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28169140/influence-of-cardiovascular-risk-factors-on-the-prevalence-of-coronary-atherosclerosis-in-patients-with-angiographically-normal-coronary-arteries
#6
Daniel O Bittner, Lutz Klinghammer, Mohamed Marwan, Jasmin Schmid, Christian Layritz, Udo Hoffmann, Stephan Achenbach, Tobias Pflederer
RATIONALE AND OBJECTIVES: Cardiovascular (CV) disease is predominately influenced by CV risk factors and coronary computed tomography angiography (CTA) is capable of detecting early-stage coronary artery disease. We sought to determine the influence of CV risk factors on the prevalence of nonobstructive atherosclerosis in patients with normal-appearing coronary arteries in invasive coronary angiography (ICA). MATERIALS AND METHODS: In this retrospective analysis, we included 60 consecutive symptomatic patients, having undergone ICA and coronary CTA...
February 3, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28168796/plasma-biomarker-levels-and-non-obstructive-coronary-artery-disease-determined-by-coronary-computed-tomography-angiography
#7
Elin B Brolin, Stefan Agewall, Kerstin Cederlund, Christina Ekenbäck, Loghman Henareh, Karin Malmqvist, Andreas Rück, Anders Svensson, Per Tornvall
PURPOSE: Coronary computed tomography angiography (CTA) and several circulating biomarkers have prognostic value regarding cardiovascular disease (CVD) events, but their association is incompletely studied. We aimed to investigate whether markers of lipid metabolism, inflammation and kidney function could predict non-obstructive coronary artery disease (CAD) determined by coronary CTA, in a low-to-intermediate-risk group. METHODS: Coronary CTA and laboratory testing were performed for 115 subjects (45-70 years), with low prevalence of CVD risk factors, predominantly low-to-intermediate Framingham risk and normal or mildly reduced kidney function...
February 6, 2017: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/28168514/limits-of-the-possible-diagnostic-image-quality-in-coronary-angiography-with-third-generation-dual-source-ct
#8
Marco M Ochs, Fabian Aus dem Siepen, Thomas Fritz, Florian Andre, Gitsios Gitsioudis, Grigorios Korosoglou, Sebastian Seitz, Yuriy Bogomazov, Christopher L Schlett, Roman Sokiranski, Andre Sommer, Friedemann Gückel, Matthias Brado, Hans-Ulrich Kauczor, Johannes Görich, Matthias G W Friedrich, Hugo A Katus, Sebastian J Buss
BACKGROUND: The usage of coronary CT angiography (CTA) is appropriate in patients with acute or chronic chest pain; however the diagnostic accuracy may be challenged with increased Agatston score (AS), increased heart rate, arrhythmia and severe obesity. Thus, we aim to determine the potential of the recently introduced third-generation dual-source CT (DSCT) for CTA in a 'real-life' clinical setting. METHODS: Two hundred and sixty-eight consecutive patients (age: 67 ± 10 years; BMI: 27 ± 5 kg/m²; 61% male) undergoing clinically indicated CTA with DSCT were included in the retrospective single-center analysis...
February 6, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28130886/classification-of-hemodynamically-significant-stenoses-from-dynamic-ct-perfusion-and-cta-myocardial-territories
#9
Marco Giordano, Dirk H J Poot, Adriaan Coenen, Theo van Walsum, Michela Tezza, Koen Nieman, Wiro J Niessen
PURPOSE: Myocardial blood flow (MBF) obtained by dynamic CT perfusion (CTP) has been recently introduced to assess hemodynamic significance of coronary stenosis in coronary artery disease. The diagnostic performance of dynamic CTP MBF is limited due to subjective interpretation of MBF maps and MBF variations caused by physiological, methodological and technical issues. In this paper we introduce a novel method to quantify the hypoperfused volume (HPV) in myocardial territories derived from CT angiography (CTA) in order to overcome the limitations of current dynamic CTP MBF analysis methods...
January 28, 2017: Medical Physics
https://www.readbyqxmd.com/read/28126699/incidental-finding-of-single-coronary-artery-in-a-patient-with-alcoholic-cardiomyopathy-presenting-as-acute-heart-failure
#10
Patrick McNair, Erica Jones, Quynh Truong, Harsimran Singh
Single coronary artery is a rare clinical finding. Diagnosis is typically made incidentally after the patient presents with symptoms and undergoes coronary angiography, coronary computed tomography angiography (CTA), or post-mortem during autopsy. Several high-risk features of anomalous coronary arteries have been described in the literature. Our paper describes a case of dilated alcoholic cardiomyopathy presenting as heart failure with diagnostic workup incidentally revealing single coronary artery.
January 16, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/28126251/difference-of-coronary-stenosis-severity-between-systolic-and-diastolic-phases-in-quantitative-ct-angiography
#11
Hui Gu, Yang Gao, Haiping Wang, Zhennan Li, Liang Xu, Bo Xu, Ximing Wang, Bin Lu
BACKGROUND: To compare the difference of coronary diameter stenosis by quantitative analysis of CT angiography (QCT) in the systolic (QCT-S) and diastolic phase (QCT-D) of the cardiac cycle, with invasive catheter angiography (QCA) as reference standard. METHODS: A total of 109 patients (57.5 ± 10.6 years, 78.9% male) with suspected coronary artery disease (CAD) who underwent both CT angiography and invasive catheter angiography were retrospectively included in this study...
January 17, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28122619/obesity-metabolic-syndrome-and-cardiovascular-prognosis-from-the-partners-coronary-computed-tomography-angiography-registry
#12
Edward A Hulten, Marcio Sommer Bittencourt, Ryan Preston, Avinainder Singh, Carla Romagnolli, Brian Ghoshhajra, Ravi Shah, Siddique Abbasi, Suhny Abbara, Khurram Nasir, Michael Blaha, Udo Hoffmann, Marcelo F Di Carli, Ron Blankstein
OBJECTIVE: To investigate the relationship among body mass index (BMI), cardiometabolic risk and coronary artery disease (CAD) among patients undergoing coronary computed tomography angiography (CTA). METHODS: Retrospective cohort study of 1118 patients, who underwent coronary CTA at two centers from September 2004 to October 2011. Coronary CTA were categorized as normal, nonobstructive CAD (<50%), or obstructive CAD (≥50%) in addition to segment involvement (SIS) and stenosis scores...
January 25, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28121952/instantaneous-wave-free-ratio-derived-from-coronary-computed-tomography-angiography-in-evaluation-of-ischemia-causing-coronary-stenosis-feasibility-and-initial-clinical-research
#13
Yue Ma, Hui Liu, Yang Hou, Aike Qiao, Yingying Hou, Qingqing Yang, Qiyong Guo
The instantaneous wave-free ratio (iFR) closely related to fractional flow reserve (FFR) is a adenosine-independent physiologic index of coronary stenosis severity. We sought to evaluate whether iFR derived from coronary computed tomographic angiography (iFRCT) can be used as a novel noninvasive method for diagnosis of ischemia-causing coronary stenosis.We retrospectively enrolled 33 patients (47 lesions) with coronary artery disease (CAD) and examined with coronary computed tomographic angiography (CTA), invasive coronary angiography (ICA), and FFR...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28117242/computed-tomography-angiography-versus-angiography-for-guiding-percutaneous-coronary-interventions-in-bifurcation-lesions-a-prospective-randomized-pilot-study
#14
Rafal Wolny, Jerzy Pregowski, Mariusz Kruk, Cezary Kepka, Gary S Mintz, Gabor G Toth, Artur Debski, Michal Ciszewski, Krzysztof Kukula, Maksymilian P Opolski, Zbigniew Chmielak, Adam Witkowski
BACKGROUND: There is no data on the impact of coronary computed tomography angiography (coronary CTA), as an addition to angiography, on the outcomes of percutaneous coronary interventions (PCI) in bifurcation lesions. METHODS: Patients with stable coronary artery disease scheduled for elective bifurcation PCI were randomized 1:1 to planning the procedure based on coronary CTA and angiography (CTA group) or angiography alone (CA group). The primary efficacy endpoint was the immediate angiographic result...
January 17, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28111212/global-quantification-of-left-ventricular-myocardial-perfusion-at-dynamic-ct-imaging-prognostic-value
#15
Felix G Meinel, Julian L Wichmann, U Joseph Schoepf, Francesca Pugliese, Ullrich Ebersberger, Gladys G Lo, Yeon Hyeon Choe, Yining Wang, Christian Tesche, Sabrina Segreto, Wolfgang G Kunz, Kolja M Thierfelder, Fabian Bamberg, Carlo N De Cecco
BACKGROUND: There is no published data on the prognostic value of global myocardial perfusion values at stress dynamic CT myocardial perfusion imaging (CTMPI). METHODS: Data of 144 patients from 6 centers who had undergone coronary CT angiography (coronary CTA) and CTMPI were assessed. Coronary CTA studies were acquired at rest; CTMPI was performed under vasodilator stress. Coronary CTA data were evaluated for coronary artery stenosis (≥50% luminal narrowing) on a per-vessel basis...
January 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28109934/coronary-plaque-burden-and-adverse-plaque-characteristics-are-increased-in-healthy-relatives-of-patients-with-early-onset-coronary-artery-disease
#16
Morten K Christiansen, Jesper M Jensen, Bjarne L Nørgaard, Damini Dey, Hans Erik Bøtker, Henrik K Jensen
OBJECTIVES: This study characterized and quantified subclinical atherosclerosis by coronary computed tomography angiography (CTA) in first-degree relatives of patients with early onset coronary artery disease (CAD). BACKGROUND: A strong family history of CAD is an important risk factor for adverse cardiovascular events. Whether predisposed individuals suffer an increased burden of coronary atherosclerosis and adverse plaque features is not known. METHODS: We included 88 healthy middle-aged first-degree relatives from 59 families with early onset CAD...
January 12, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28109933/integrating-ct-myocardial-perfusion-and-ct-ffr-in-the-work-up-of-coronary-artery%C3%A2-disease
#17
Adriaan Coenen, Alexia Rossi, Marisa M Lubbers, Akira Kurata, Atsushi K Kono, Raluca G Chelu, Sabrina Segreto, Marcel L Dijkshoorn, Andrew Wragg, Robert-Jan M van Geuns, Francesca Pugliese, Koen Nieman
OBJECTIVES: The aim of this study was to investigate the individual and combined accuracy of dynamic computed tomography (CT) myocardial perfusion imaging (MPI) and computed tomography angiography (CTA) fractional flow reserve (FFR) for the identification of functionally relevant coronary artery disease (CAD). BACKGROUND: Coronary CTA has become an established diagnostic test for ruling out CAD, but it does not allow interpretation of the hemodynamic severity of stenotic lesions...
January 12, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28089233/epicardial-adipose-tissue-and-myocardial-ischemia-assessed-by-computed-tomography-perfusion-imaging-and-invasive-fractional-flow-reserve
#18
Rahul G Muthalaly, Nitesh Nerlekar, Dennis T L Wong, James D Cameron, Sujith K Seneviratne, Brian S Ko
BACKGROUND: Epicardial adipose tissue (EAT) is a metabolically active fat depot that is associated with incident coronary artery disease (CAD) and major adverse cardiovascular events. The relationship between EAT and myocardial ischemia remains unclear. This study investigated the relationship between EAT volume and the presence of perfusion defects on myocardial computed tomographic perfusion imaging (CTP) and functional stenoses on invasive fractional flow-reserve (FFR). METHODS: Data were obtained from a previous prospective cross-sectional study in patients with suspected CAD...
January 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28065380/iterative-model-reconstruction-reduces-calcified-plaque-volume-in-coronary-ct-angiography
#19
Mihály Károlyi, Bálint Szilveszter, Márton Kolossváry, Richard A P Takx, Csilla Celeng, Andrea Bartykowszki, Ádám L Jermendy, Alexisz Panajotu, Júlia Karády, Rolf Raaijmakers, Walter Giepmans, Béla Merkely, Pál Maurovich-Horvat
OBJECTIVE: To assess the impact of iterative model reconstruction (IMR) on calcified plaque quantification as compared to filtered back projection reconstruction (FBP) and hybrid iterative reconstruction (HIR) in coronary computed tomography angiography (CTA). METHODS: Raw image data of 52 patients who underwent 256-slice CTA were reconstructed with IMR, HIR and FBP. We evaluated qualitative, quantitative image quality parameters and quantified calcified and partially calcified plaque volumes using automated software...
February 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28048867/mo-ab-bra-10-super-high-temporal-resolution-cardiac-ct-imaging-using-smart-recon
#20
Y Li, X Cao, Z Xing, X Sun, J Hsieh, G Chen
PURPOSE: Coronary CT angiography is a challenging task currently limited by the achievable temporal resolution of modern MDCT scanners. In this work, a highly innovative method has been developed and validated to improve temporal resolution of the MDCT by a factor of four with the newly developed SMART-RECON method to enable high quality coronary CTA exams. The primary purpose of this paper is to investigate the relationships between: (1) SMART-RECON and the motion pattern; (2) SMART-RECON and the average speed of moving vessels; (3) SMART-RECON and the position and direction of moving vessels...
June 2016: Medical Physics
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