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https://www.readbyqxmd.com/read/29031185/diet-quality-and-depression-risk-a-systematic-review-and-dose-response-meta-analysis-of-prospective-studies
#1
REVIEW
Marc Molendijk, Patricio Molero, Felipe Ortuño Sánchez-Pedreño, Willem Van der Does, Miguel Angel Martínez-González
BACKGROUND: It has been claimed that the quality of a diet is associated with the incidence of depressive disorders. We sought to investigate the evidence for this claim. METHODS: Systematic searches were performed up to March 6th, 2017 in order to identify prospective cohort studies that reported on exposure to dietary patterns or food groups and the incidence of depression/depressive symptoms. Data from 24 independent cohorts (totalling 1,959,217 person-years) were pooled in random-effects meta-analyses...
September 23, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29031181/mdhy5-positively-regulates-cold-tolerance-via-cbf-dependent-and-cbf-independent-pathways-in-apple
#2
Jian-Ping An, Ji-Fang Yao, Xiao-Na Wang, Chun-Xiang You, Xiao-Fei Wang, Yu-Jin Hao
Cold stress is a major external stimulator that affects crop quality and productivity. The CBF cold regulatory pathway has been regarded as a master regulator in the response to cold stress. In this study, we found that the apple bZIP transcription factor, MdHY5, was responsive to cold treatment both at the transcriptional and at the post-translational levels. Moreover, overexpression of MdHY5 enhanced cold tolerance in apple calli and Arabidopsis. Subsequently, EMSA assay and transient expression assay demonstrated that MdHY5 positively regulated the transcript of MdCBF1 by binding to G-Box motif of its promoter...
September 7, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/29031157/a-european-multi-centre-external-quality-assessment-eqa-study-on-phenotypic-and-genotypic-methods-used-for-herpes-simplex-virus-hsv-drug-resistance-testing
#3
Baharak Afshar, David F Bibby, Renata Piorkowska, Natasha Ohemeng-Kumi, Robert Snoeck, Graciela Andrei, Sarah Gillemot, Florence Morfin, Emilie Frobert, Sonia Burrel, David Boutolleau, Brendan Crowley, Jean L Mbisa
BACKGROUND: Herpes Simplex Virus (HSV) drug resistance is a significant public health concern among immunocompromised individuals. Phenotypic assays are considered the gold standard method for detecting HSV drug resistance. However, plaque reduction assays (PRAs) are technically demanding, often with long turnaround times of up to four weeks. In contrast, genotypic tests can be performed within a few days. OBJECTIVES: The development and coordination of the first European External Quality Assessment (EQA) study to evaluate phenotypic and genotypic methods used for HSV drug resistance testing in specialised reference laboratories...
October 6, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29031133/nmr-diffusometry-data-sampling-optimization-for-mixture-analysis
#4
Florence Franconi, Laurent Lemaire, Benjamin Siegler, Jean-Christophe Gimel, Patrick Saulnier
NMR diffusometry is a powerful but challenging method to analyze complex mixture. Each component diffuses differently, from the faster small species to the slower large species, corresponding to different signal attenuation. However, the method is highly sensitive to the quality of the acquired data and the performance of the processing used to resolve multiexponential signals influences. Adapting the signal decay sampling to the mixture composition is one way to improve the precision of the measure. In this work, we propose a prediction tool, based on the calculation of the Cramér-Rao lower bound to minimize the variance of diffusion coefficient estimation in order to determine the optimal number of diffusion gradient steps, the best diffusion gradient sampling (among linear, exponential, quadratic and sigmoidal ones) and the optimal maximum diffusion factor...
October 2, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29031104/evaluation-of-the-gauss-eyring-model-to-predict-thermal-inactivation-of-micro-organisms-at-short-holding-times
#5
R A H Timmermans, H C Mastwijk, M N Nierop Groot, M A J S Van Boekel
Application of mild (non)-thermal processing technologies have received considerable interest as alternative to thermal pasteurisation, because of its shorter holding time and lower temperature aiming for an improved product quality. To understand and develop these alternative technologies, like pulsed electric fields, a proper comparison between the conventional thermal and alternative process is necessary. Up to recent, no suitable models were available to predict the inactivation of micro-organisms by a thermal process at a chosen short holding time, due to non-linearity...
October 2, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29031081/optimization-of-the-promega-powerseq%C3%A2-auto-y-system-for-efficient-integration-within-a-forensic-dna-laboratory
#6
E A Montano, J M Bush, A M Garver, M M Larijani, S M Wiechman, C H Baker, M R Wilson, R A Guerrieri, E A Benzinger, D N Gehres, M L Dickens
The application of massively parallel sequencing (MPS) is growing in the forensic DNA field, as forensic DNA laboratories are continuously seeking methods to gain information from a limited or degraded forensic sample. However, the laborious nature of current MPS methodologies required for successful library preparation and sequencing leave opportunities for improvement to make MPS a practical option for processing forensic casework. In this study, the Promega PowerSeq™ Auto/Y System Prototype, a MPS laboratory workflow that incorporates multiplex amplification, was selected for optimization with the objectives to introduce automation for relieving manual processing, and to reduce the number of steps recommended by the standard protocol...
October 5, 2017: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/29031037/-evaluation-of-anti-cancer-therapies-with-reimbursement-limited-to-comprehensive-cancer-centres-using-the-european-society-for-medical-oncology-magnitude-of-clinical-benefit-scale
#7
T Büchler, B Melichar, D Vrána, R Lemstrová, J Fínek, L Dušek, K Petráková, J Prausová
BACKGROUND: The costs of oncology treatments are increasing, due to the rising prevalence of malignant diseases and the introduction of expensive novel anti-cancer agents. The new European Society for Clinical Oncology (ESMO) has recently developed a new parametric system to evaluate the clinical benefit of drugs. The Magnitude of Clinical Benefit Scale (ESMO-MCBS) compares the contribution of a novel drug based on overall and progression-free survival and quality of life with those of current treatment options...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/29031035/-controversy-in-the-postoperative-treatment-of-low-grade-gliomas
#8
T Kazda, R Lakomý, A Poprach, P Pospíšil, R Jančálek, P Šlampa
BACKGROUND: The optimal treatment for low-grade gliomas remains controversial. Neurosurgery, radiotherapy, and chemotherapy are the main treatment options. Despite advances in oncology, there are still a lot of uncertainties, and the optimal sequences, combinations, and timings of these procedures have not yet been optimized. It is still unclear whether temozolomide can replace effective, but toxic PCV chemotherapy (procarbazine, lomustine, vincristine) and whether temozolomide can be used upfront alone instead of radiotherapy alone...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/29031018/strategies-to-define-performance-specifications-in-laboratory-medicine-3-years-on-from-the-milan-strategic-conference
#9
Mauro Panteghini, Ferruccio Ceriotti, Graham Jones, Wytze Oosterhuis, Mario Plebani, Sverre Sandberg
Measurements in clinical laboratories produce results needed in the diagnosis and monitoring of patients. These results are always characterized by some uncertainty. What quality is needed and what measurement errors can be tolerated without jeopardizing patient safety should therefore be defined and specified for each analyte having clinical use. When these specifications are defined, the total examination process will be "fit for purpose" and the laboratory professionals should then set up rules to control the measuring systems to ensure they perform within specifications...
October 14, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29031017/how-to-reduce-scientific-irreproducibility-the-5-year-reflection
#10
Clare Fiala, Eleftherios P Diamandis
We discuss in depth six causes of scientific irreproducibility and their ramifications for the clinical sciences: fraud, unfounded papers published by prominent authorities, bias, technical deficiencies, fragmented science and problems with big data. Some proposed methods to combat this problem are briefly described, including an effort to replicate results from some high impact papers and a proposal that authors include detailed preclinical data in papers with supposedly high translational value. We here advocate for a 5-year reflection on papers with seemingly high clinical/translational potential, published alongside the original paper where authors reflect on the quality, reproducibility and impact of their findings...
October 14, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29029368/who-accesses-surgery-at-district-level-in-sub-saharan-africa-evidence-from-malawi-and-zambia
#11
Jakub Gajewski, Rachel Dharamshi, Michael Strader, John Kachimba, Eric Borgstein, Gerald Mwapasa, Mweene Cheelo, Tracey McCauley, Leon Bijlmakers, Ruairi Brugha
OBJECTIVES: To examine age and gender distribution for the most common types of surgery in Malawi and Zambia. METHODS: Data were collected from major operating theatres in 8 district hospitals in Malawi and 9 in Zambia. Raw data on surgical procedures were coded by specialist surgeons for frequency analyses. RESULTS: In Malawi, female surgical patients had a mean age of 25 years, with 91% aged 16-40 years. Females accounted for 85%, and obstetric cases for 75%, of all surgical patients...
October 13, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29029338/to-include-or-not-to-include-the-impact-of-gene-filtering-on-species-tree-estimation-methods
#12
Erin K Molloy, Tandy Warnow
With the increasing availability of whole genome data, many species trees are being constructed from hundreds to thousands of loci. Although concatenation analysis using maximum likelihood is a standard approach for estimating species trees, it does not account for gene tree heterogeneity, which can occur due to many biological processes, such as incomplete lineage sorting. Coalescent species tree estimation methods, many of which are statistically consistent in the presence of incomplete lineage sorting, include Bayesian methods that co-estimate the gene trees and the species tree, summary methods that compute the species tree by combining estimated gene trees, and site-based methods that infer the species tree from site patterns in the alignments of different loci...
September 15, 2017: Systematic Biology
https://www.readbyqxmd.com/read/29029258/acupuncture-improves-peri-menopausal-insomnia-a-randomized-controlled-trial
#13
Fu Cong, Zhao Na, Liu Zhen, Yuan Lu-Hua, Xie Chen, Yang Wen-Jia, Yu Xin-Tong, Yu Huan, Chen Yun-Fei
Study Objective: To evaluate the short-term efficacy of acupuncture for the treatment of peri-menopausal insomnia (PMI). Methods: Design: A randomized, participant-blind, placebo-controlled trial consisted of the acupuncture group (n=38) and placebo-acupuncture group (n=38). Setting: A tertiary teaching and general hospital. Participants: 76 peri-menopausal women with insomnia disorder based on the International Classification of Sleep Disorders, third Edition. Interventions: A 10-session of acupuncture at bilateral Shenshu (BL 23) and Ganshu (BL 18) with unilateral Qimen (LR 14) and Jingmen (GB 25) or Streitberger needles at the same acupoints was performed for over 3 weeks...
September 22, 2017: Sleep
https://www.readbyqxmd.com/read/29029241/fragmentary-gene-sequences-negatively-impact-gene-tree-and-species-tree-reconstruction
#14
Erfan Sayyari, James B Whitfield, Siavash Mirarab
Species tree reconstruction from genome-wide data is increasingly being attempted, in most cases using a two-step approach of first estimating individual gene trees and then summarizing them to obtain a species tree. The accuracy of this approach, which promises to account for gene tree discordance, depends on the quality of the inferred gene trees. At the same time, phylogenomic and phylotranscriptomic analyses typically use involved bioinformatics pipelines for data preparation. Errors and shortcomings resulting from these preprocessing steps may impact the species tree analyses at the other end of the pipeline...
October 4, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/29029213/recovery-kinetics-of-radiographic-and-implant-related-revision-patients-following-adult-spinal-deformity-surgery
#15
Peter G Passias, Cyrus M Jalai, Virginie Lafage, Gregory W Poorman, Shaleen Vira, Samantha R Horn, Justin K Scheer, D Kojo Hamilton, Breton G Line, Shay Bess, Frank J Schwab, Christopher P Ames, Douglas C Burton, Robert A Hart, Eric O Klineberg
BACKGROUND: Prior studies have observed similar health-related quality of life (HRQL) in revisions and nonrevision (NR) patients following adult spinal deformity (ASD) correction. However, a novel comparison approach may allow better comparisons in spine outcomes groups. OBJECTIVE: To determine if ASD revisions for radiographic and implant-related complications undergo a different recovery than NR patients. METHODS: Inclusion: ASD patients with complete HRQL (Oswestry Disability Index, Short-Form-36 version 2 (SF-36), Scoliosis Research Society [SRS]-22) at baseline, 6 wk, 1 yr, 2 yr...
October 6, 2017: Neurosurgery
https://www.readbyqxmd.com/read/29029178/expansion-of-viral-load-testing-and-the-potential-impact-on-human-immunodeficiency-virus-drug-resistance
#16
Helen M Chun, Yaa F Obeng-Aduasare, Laura N Broyles, Dennis Ellenberger
Increasing the volume, strengthening the quality, and proactively using data of human immunodeficiency virus (HIV) load testing are pivotal to limiting the threat of HIV drug resistance (HIVDR) accumulation,and allow for optimal case-based HIVDR surveillance. Triangulation of viral load (VL) and HIVDR testing data could be pursued to answer key questions and translate data and results for program and public policy. Identification of virologic failure and early management mitigates the greater risk of HIVDR...
October 5, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29029117/the-european-registry-for-patients-with-mechanical-circulatory-support-euromacs-of-the-european-association-for-cardio-thoracic-surgery-eacts-second-report
#17
Theo M M H de By, Paul Mohacsi, Brigitta Gahl, Armin Zittermann, Thomas Krabatsch, Finn Gustafsson, Pascal Leprince, Bart Meyns, Ivan Netuka, Kadir Caliskan, Evaristo Castedo, Francesco Musumeci, André Vincentelli, Roland Hetzer, Jan Gummert
OBJECTIVES: The European Registry for Patients with Mechanical Circulatory Support (EUROMACS) was founded in Berlin, Germany. EUROMACS is supported fully by the European Association for Cardio-Thoracic Surgery (EACTS) and, since 2014, has functioned as a committee of the EACTS. The purpose of having the EUROMACS as a part of the EACTS is to accumulate clinical data related to long-term mechanical circulatory support for scientific purposes and to publish annual reports. METHODS: Participating hospitals contributed surgical and cardiological pre-, peri- and long-term postoperative data of mechanical circulatory support implants to the registry...
September 29, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29029075/improving-health-systems-performance-in-low-and-middle-income-countries-a-system-dynamics-model-of-the-pay-for-performance-initiative-in-afghanistan
#18
O Alonge, S Lin, T Igusa, D H Peters
System dynamics methods were used to explore effective implementation pathways for improving health systems performance through pay-for-performance (P4P) schemes. A causal loop diagram was developed to delineate primary causal relationships for service delivery within primary health facilities. A quantitative stock-and-flow model was developed next. The stock-and-flow model was then used to simulate the impact of various P4P implementation scenarios on quality and volume of services. Data from the Afghanistan national facility survey in 2012 was used to calibrate the model...
September 23, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29029029/a-manifesto-for-cardiovascular-imaging-addressing-the-human-factor
#19
Alan G Fraser
Our use of modern cardiovascular imaging tools has not kept pace with their technological development. Diagnostic errors are common but seldom investigated systematically. Rather than more impressive pictures, our main goal should be more precise tests of function which we select because their appropriate use has therapeutic implications which in turn have a beneficial impact on morbidity or mortality. We should practise analytical thinking, use checklists to avoid diagnostic pitfalls, and apply strategies that will reduce biases and avoid overdiagnosis...
September 28, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29028988/quasar-mpra-accurate-allele-specific-analysis-for-massively-parallel-reporter-assays
#20
Cynthia A Kalita, Gregory A Moyerbrailean, Christopher Brown, Xiaoquan Wen, Francesca Luca, Roger Pique-Regi
Motivation: The majority of the human genome is composed of non-coding regions containing regulatory elements such as enhancers, which are crucial for controlling gene expression. Many variants associated with complex traits are in these regions, and may disrupt gene regulatory sequences. Consequently, it is important to not only identify true enhancers but also to test if a variant within an enhancer affects gene regulation. Recently, allele-specific analysis in high-throughput reporter assays, such as massively parallel reporter assays (MPRA), have been used to functionally validate non-coding variants...
September 22, 2017: Bioinformatics
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