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longitudinal and data and quality and assessment

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https://www.readbyqxmd.com/read/29138610/nab-paclitaxel-carboplatin-induction-in-squamous-nsclc-longitudinal-quality-of-life-while-on-chemotherapy
#1
Michael Thomas, David R Spigel, Robert M Jotte, Michael McCleod, Mark A Socinski, Ray D Page, Laurent Gressot, Jeanna Knoble, Oscar Juan, Daniel Morgensztern, Dolores Isla, Edward S Kim, Howard West, Amy Ko, Teng Jin Ong, Nataliya Trunova, Cesare Gridelli
Background: Longitudinal data on the impact of treatment on quality of life (QoL) in advanced non-small cell lung cancer (NSCLC) are limited. In this palliative setting, treatment that does not deteriorate QoL is key. Here we report longitudinal QoL in patients with squamous NSCLC, receiving ≤4 cycles of nab-paclitaxel/carboplatin combination chemotherapy. Methods: Patients received nab-paclitaxel 100 mg/m(2) days 1, 8, 15 + carboplatin area under the curve 6 mg•min/mL day 1 (q3w) for four cycles...
2017: Lung Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/29136003/longitudinal-acquisition-of-endotracheal-intubation-skills-in-novice-physicians
#2
Shinya Takeuchi, Takashi Shiga, Yasuaki Koyama, Taizo Nakanishi, Yosuke Honma, Hiroshi Morita, Tadahiro Goto
Little is known about the acquisition of intubation skills among novice physicians during their one-year clinical training. Our primary objective was to determine the changes in the intubation skills of novice physicians between prior to the clinical training and after completion of the clinical training. We used data of a prospective longitudinal multicenter data registry developed to investigate factors associated with the improvement of intubation skills among novice physicians. The study participants included 90 postgraduate year 1 physicians in 2015-2016...
2017: PloS One
https://www.readbyqxmd.com/read/29135992/internal-quality-assurance-in-diagnostic-microbiology-a-simple-approach-for-insightful-data
#3
Valentin Scherz, Christian Durussel, Gilbert Greub
Given the importance of microbiology results on patient care, high quality standards are expected. Internal quality assurance (IQA) could mitigate the limitations of internal quality control, competency assessment and external quality assurance, adding a longitudinal insight, including pre- and post-analytical steps. Here, we implemented an IQA program in our clinical microbiology facilities with blind resubmission of routine samples during 22 months. One-hundred-and-twenty-one out of 123 (98.4%) serological analyses and 112 out of 122 (91...
2017: PloS One
https://www.readbyqxmd.com/read/29129348/performance-of-the-tinnitus-functional-index-as-a-diagnostic-instrument-in-a-uk-clinical-population
#4
Kathryn Fackrell, Deborah A Hall, Johanna G Barry, Derek J Hoare
OBJECTIVES: The Tinnitus Functional Index (TFI) has been optimised as a diagnostic tool for quantifying the functional impact of tinnitus in US veteran and civilian groups. However, the TFI has not been fully evaluated for use in other English-speaking clinical populations despite its increasingly popular uptake. Here, a prospective multi-site longitudinal validation study was conducted to evaluate psychometric properties relevant to the UK clinical population. Guided by quality criteria for the measurement properties of health-related questionnaires, we specifically evaluated three diagnostic properties relating to the degree to which the TFI (i) covers the eight dimensions proposed to be important for diagnosis, (ii) reliably distinguishes individual differences in severity of tinnitus, and (iii) reliably measures the functional impact of tinnitus...
November 9, 2017: Hearing Research
https://www.readbyqxmd.com/read/29128275/a-longitudinal-study-of-motivations-before-and-psychosexual-outcomes-after-genital-gender-confirming-surgery-in-transmen
#5
Tim C van de Grift, Garry L S Pigot, Siham Boudhan, Lian Elfering, Baudewijntje P C Kreukels, Luk A C L Gijs, Marlon E Buncamper, Müjde Özer, Wouter van der Sluis, Eric J H Meuleman, Mark-Bram Bouman, Margriet G Mullender
BACKGROUND: Genital dissatisfaction is an important reason for transmen to undergo genital gender-confirming surgery (GCS; phalloplasty or metoidioplasty). However, little is known about motives for choosing specific techniques, how transmen benefit postoperatively, and whether psychosexual outcomes improve. AIM: To evaluate motivations for and psychosexual outcomes after GCS. METHODS: A longitudinal study of 21 transmen at least 1 year after GCS was conducted...
November 8, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29119008/discordant-patient-physician-assessments-of-disease-activity-and-its-persistence-adversely-impact-quality-of-life-and-work-productivity-in-us-hispanics-with-rheumatoid-arthritis
#6
George A Karpouzas, Sera N Ramadan, Chelsie E Cost, Taylor L Draper, Elizabeth Hernandez, Vibeke Strand, Sarah R Ormseth
Objective: This study was designed to evaluate the determinants of patient and physician global assessments (PtGA and MDGA, respectively) of disease activity, their discordance and change over 2 years in Hispanics with rheumatoid arthritis (RA). We further examined the impact of discordance and its persistence on health-related quality of life (HRQOL) and work productivity on final visit. Methods: We studied 536 Hispanics with established RA from a single centre...
2017: RMD Open
https://www.readbyqxmd.com/read/29117252/preclinical-4d-flow-magnetic-resonance-phase-contrast-imaging-of-the-murine-aortic-arch
#7
Moritz Braig, Jochen Leupold, Marius Menza, Maximilian Russe, Cheng-Wen Ko, Juergen Hennig, Dominik von Elverfeldt
PURPOSE: Cardiovascular diseases remain the number one death cause worldwide. Preclinical 4D flow phase contrast magnetic resonance imaging can provide substantial insights in the analysis of aortic pathophysiologies in various animal models. These insights may allow a better understanding of pathophysiologies, therapy monitoring, and can possibly be translated to humans. This study provides a framework to acquire the velocity field within the aortic arch. It analyses important flow values at different locations within the aortic arch...
2017: PloS One
https://www.readbyqxmd.com/read/29116979/translating-theory-into-practice-implementing-a-program-of-assessment
#8
Karen E Hauer, Patricia S O'Sullivan, Kristen Fitzhenry, Christy Boscardin
PROBLEM: A program of assessment addresses challenges in learner assessment using a centrally planned, coordinated approach that emphasizes assessment for learning. This report describes the steps taken to implement a program of assessment framework within a medical school. APPROACH: A literature review on best practices in assessment highlighted six principles that guided implementation of the program of assessment in 2016-2017: (1) a centrally coordinated plan for assessment aligns with and supports a curricular vision; (2) multiple assessment tools used longitudinally generate multiple data points; (3) learners require ready access to information-rich feedback to promote reflection and informed self-assessment; (4) mentoring is essential to facilitate effective data use for reflection and learning planning; (5) the program of assessment fosters self-regulated learning behaviors; and (6) expert groups make summative decisions about grades and readiness for advancement...
November 7, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29112038/calculating-state-level-estimates-of-upcoming-older-adult-health-needs
#9
Dora M Dumont, Junhie Oh, Tracy L Jackson, Tara Cooper
OBJECTIVES: Census demographers have provided projections of the increased numbers of older adults in upcoming decades, but it is less clear whether they will also be any more or less healthy than current seniors. This is critical information for state planners, as the majority of older adults will need assistance with activities of daily living to remain in their homes. Previous longitudinal and cohort studies have yielded national estimates, but those more costly sources are generally beyond the resources of state public health agencies...
November 2, 2017: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/29105347/outcomes-after-complete-endoscopic-sinus-surgery-and-aspirin-desensitization-in-aspirin-exacerbated-respiratory-disease
#10
Nithin D Adappa, Viran J Ranasinghe, Michal Trope, Steven G Brooks, Jordan T Glicksman, Arjun K Parasher, James N Palmer, John V Bosso
BACKGROUND: In this study we assessed patient outcomes after complete endoscopic sinus surgery (ESS) and aspirin desensitization for patients with aspirin-exacerbated respiratory disease (AERD). METHODS: A retrospective chart review was conducted for patients with aspirin challenge-proven AERD who underwent complete ESS followed by aspirin desensitization. Outcomes assessed included need for revision surgery and quality-of-life measures using the 22-item Sino-Nasal Outcomes Test (SNOT-22)...
November 3, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29083329/selenium-homeostasis-and-clustering-of-cardiovascular-risk-factors-a-systematic-review
#11
Mojgan Gharipour, Masoumeh Sadeghi, Mehrdad Behmanesh, Mansour Salehi, Pouya Nezafati, Amin Gharpour
  Selenium is a trace element required for a range of cellular functions. It is widely used for the biosynthesis of the unique amino acid selenocysteine [Sec], which is a structural element of selenoproteins. This systematic review focused on the possible relation between selenium and metabolic risk factors. The literature was searched via PubMed, Scopus, ISI Web of Science, and Google Scholar. Searches were not restricted by time or language. Relevant studies were selected in three phases. After an initial quality assessment, two reviewers extracted all the relevant data, whereas the third reviewer checked their extracted data...
October 23, 2017: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29079060/omega-3-fatty-acid-supplementation-may-prevent-loss-of-gray-matter-thickness-in-the-left-parieto-occipital-cortex-in-first-episode-schizophrenia-a-secondary-outcome-analysis-of-the-offer-randomized-controlled-study
#12
Tomasz Pawełczyk, Ewa Piątkowska-Janko, Piotr Bogorodzki, Piotr Gębski, Marta Grancow-Grabka, Elżbieta Trafalska, Natalia Żurner, Agnieszka Pawełczyk
The aim of the study was to assess changes in cortical thickness related to the use of n-3 polyunsaturated fatty acids (PUFA) as add-on therapy in patients with first episode schizophrenia. A double-blind randomized controlled study was conducted using a 26-week intervention composed of concentrated fish oil containing 2.2g/d of eicosapentaenoic (EPA) and docosahexaenoic acid (DHA) or placebo (olive oil). Participants underwent MRI scanning twice to assess changes in cortical thickness: at the beginning and at the end of intervention...
October 24, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29075740/long-term-functional-and-quality-of-life-outcomes-after-transoral-robotic-surgery-in-patients-with-oropharyngeal-cancer
#13
Virginie Achim, Rachel K Bolognone, Andrew D Palmer, Donna J Graville, Tyler J Light, Ryan Li, Neil Gross, Peter E Andersen, Daniel Clayburgh
Importance: In recent years, transoral robotic surgery (TORS) has emerged as a useful treatment for oropharyngeal squamous cell carcinoma (OPSCC). In appropriately selected patients, the use of TORS may allow avoidance of adjuvant chemotherapy and/or radiotherapy, thereby avoiding the long-term adverse effects of these therapies. Objective: To compare functional speech, swallowing, and quality-of-life outcomes longitudinally between those undergoing TORS only and those undergoing TORS and adjuvant radiotherapy (TORS+RT) or TORS and chemoradiotherapy (TORS+CRT)...
October 26, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29066997/recommendations-for-the-use-of-automated-gray-matter-segmentation-tools-evidence-from-huntington-s-disease
#14
Eileanoir B Johnson, Sarah Gregory, Hans J Johnson, Alexandra Durr, Blair R Leavitt, Raymund A Roos, Geraint Rees, Sarah J Tabrizi, Rachael I Scahill
The selection of an appropriate segmentation tool is a challenge facing any researcher aiming to measure gray matter (GM) volume. Many tools have been compared, yet there is currently no method that can be recommended above all others; in particular, there is a lack of validation in disease cohorts. This work utilizes a clinical dataset to conduct an extensive comparison of segmentation tools. Our results confirm that all tools have advantages and disadvantages, and we present a series of considerations that may be of use when selecting a GM segmentation method, rather than a ranking of these tools...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29066020/repeat-gram-negative-hospital-acquired-infections-and-antibiotic-susceptibility-a-systematic-review
#15
REVIEW
Mansi Agarwal, Stephanie Shiau, Elaine L Larson
Repeat HAIs among frequently hospitalized patients may be contributing to the high rates of antibiotic resistance seen in gram-negative bacteria (GNB) in hospital settings. This systematic review examines the state of the literature assessing the association between repeat GNB HAIs and changes in antibiotic susceptibility patterns. A systematic search of English language published literature was conducted to identify studies in peer-reviewed journals from 2000 to 2015. Studies must have assessed drug resistance in repeat GNB infections longitudinally at the patient level...
October 20, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/29059120/change-in-depression-confidence-and-physical-function-among-older-adults-with-mild-cognitive-impairment
#16
Jennifer L Ellis, Peter Altenburger, Yvonne Lu
BACKGROUND AND PURPOSE: Nearly a quarter of those in the United States older than 71 years experience mild cognitive impairment. Persons with mild cognitive impairment battle depression and progressive disengagement from daily activities, which contribute to participation restriction and activity limitation. Daily engagement in meaningful activity (DEMA) is a tailored intervention designed to benefit persons with mild cognitive impairment and their caregivers through preserved engagement and supported adjustment to cognitive changes...
October 20, 2017: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/29054736/bidirectional-associations-between-adolescents-sexual-behaviors-and-psychological-well-being
#17
Raquel Nogueira Avelar E Silva, Daphne van de Bongardt, Laura Baams, Hein Raat
PURPOSE: Assessing bidirectional longitudinal associations between early sexual behaviors (≤16.0 years) and psychological well-being (global self-esteem, physical self-esteem, depression) among 716 adolescents, and the direct and buffering effect of parent-adolescent relationship quality. METHODS: We used data from Project STARS (Studies on Trajectories of Adolescent Relationships and Sexuality), a longitudinal study on adolescent sexual development in the Netherlands...
October 17, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/29053651/association-between-obesity-and-periodontal-disease-a-systematic-review-of-epidemiological-studies-and-controlled-clinical-trials
#18
M Martinez-Herrera, J Silvestre-Rangil, F-J Silvestre
BACKGROUND: Obesity is a very prevalent chronic disease worldwide and has been suggested to increase susceptibility of periodontitis. The aim of this paper was to provide a systematic review of the association between obesity and periodontal disease, and to determine the possible mechanisms underlying in this relationship. MATERIAL AND METHODS: A literature search was carried out in the databases PubMed-Medline and Embase. Controlled clinical trials and observational studies identifying periodontal and body composition parameters were selected...
November 1, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29053650/quality-of-life-after-upper-third-molar-removal-a-prospective-longitudinal-study
#19
V Avellaneda-Gimeno, R Figueiredo, E Valmaseda-Castellón
BACKGROUND: Third molar extraction is a very common procedure in Dentistry. The aim of this study was to evaluate the quality of life (QoL) and satisfaction of patients undergoing extraction of an upper third molar under local anesthesia. A second objective was to describe the evolution of self-reported pain measured in a visual analogue scale (VAS) in the 7 days after surgery and its relationship with pre- and intraoperative factors. MATERIAL AND METHODS: A prospective longitudinal cohort study was made...
November 1, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29053225/histological-outcomes-of-anal-high-grade-cytopredictions
#20
Jennifer Margaret Roberts, Fengyi Jin, Isobel Mary Poynten, Carmella Law, David James Templeton, Julia Kathleen Thurloe, Suzanne Marie Garland, Andrew Edwin Grulich, Annabelle Farnsworth, Richard John Hillman
BACKGROUND: Longitudinal studies of histological outcomes after anal cytological screening in men who have sex with men (MSM) are rare. This study measured the positive predictive values (PPVs) of each level of baseline cytological abnormality in MSM in Sydney, Australia, over a 12-month period. METHODS: The Study of the Prevention of Anal Cancer is a 3-year prospective study of the natural history of anal human papillomavirus infection in MSM at least 35 years old...
October 20, 2017: Cancer
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