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longitudinal study data quality control

Carolina Souza Neves da Costa, Sandra L Saavedra, Nelci Adriana Cicuto Ferreira Rocha, Marjorie H Woollacott
BACKGROUND: External support has been viewed as an important biomechanical constraint for children with deficits in postural control. Nonlinear analysis of head stability is necessary to confirm benefits of interaction between external trunk support and level of trunk control. OBJECTIVE: To compare the effect of biomechanical constraints (trunk support) on neural control of head stability during development of trunk control. DESIGN: Quasi-experimental repeated measure study...
October 6, 2016: Physical Therapy
James D Chalmers, Stefano Aliberti, Eva Polverino, Montserrat Vendrell, Megan Crichton, Michael Loebinger, Katerina Dimakou, Ian Clifton, Menno van der Eerden, Gernot Rohde, Marlene Murris-Espin, Sarah Masefield, Eleanor Gerada, Michal Shteinberg, Felix Ringshausen, Charles Haworth, Wim Boersma, Jessica Rademacher, Adam T Hill, Timothy Aksamit, Anne O'Donnell, Lucy Morgan, Branislava Milenkovic, Leandro Tramma, Joao Neves, Rosario Menendez, Perluigi Paggiaro, Victor Botnaru, Sabina Skrgat, Robert Wilson, Pieter Goeminne, Anthony De Soyza, Tobias Welte, Antoni Torres, J Stuart Elborn, Francesco Blasi
Bronchiectasis is one of the most neglected diseases in respiratory medicine. There are no approved therapies and few large-scale, representative epidemiological studies. The EMBARC (European Multicentre Bronchiectasis Audit and Research Collaboration) registry is a prospective, pan-European observational study of patients with bronchiectasis. The inclusion criterion is a primary clinical diagnosis of bronchiectasis consisting of: 1) a clinical history consistent with bronchiectasis; and 2) computed tomography demonstrating bronchiectasis...
January 2016: ERJ Open Research
Imran Petkar, Keith Rooney, Justin W G Roe, Joanne M Patterson, David Bernstein, Justine M Tyler, Marie A Emson, James P Morden, Kathrin Mertens, Elizabeth Miles, Matthew Beasley, Tom Roques, Shreerang A Bhide, Kate L Newbold, Kevin J Harrington, Emma Hall, Christopher M Nutting
BACKGROUND: Persistent dysphagia following primary chemoradiation (CRT) for head and neck cancers can have a devastating impact on patients' quality of life. Single arm studies have shown that the dosimetric sparing of critical swallowing structures such as the pharyngeal constrictor muscle and supraglottic larynx can translate to better functional outcomes. However, there are no current randomised studies to confirm the benefits of such swallow sparing strategies. The aim of Dysphagia/Aspiration at risk structures (DARS) trial is to determine whether reducing the dose to the pharyngeal constrictors with dysphagia-optimised intensity- modulated radiotherapy (Do-IMRT) will lead to an improvement in long- term swallowing function without having any detrimental impact on disease-specific survival outcomes...
October 6, 2016: BMC Cancer
Annemieke van Dongen-Leunis, W Ken Redekop, Carin A Uyl-de Groot
OBJECTIVES: The aim of this study was to assess the validity and interpretability of different preference-based questionnaires (generic 5-level EuroQol five-dimensional questionnaire [EQ-5D-5L], cancer-specific Quality of Life Questionnaire Preference-Based Measure, and European Organization of Randomized Controlled Trials 8 Dimension [EORTC-8D]) in patients with acute leukemia. METHODS: Patients who participated in Hemato-Oncologie voor Volwassenen Nederland (HOVON - the Haemato Oncology Foundation for Adults in the Netherlands) clinical trials between 1999 and 2011 at a single hospital were invited to complete the questionnaires...
September 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
F Belva, M Bonduelle, M Roelants, D Michielsen, A Van Steirteghem, G Verheyen, H Tournaye
STUDY QUESTION: What is the semen quality of young adult men who were conceived 18-22 years ago by ICSI for male infertility? SUMMARY ANSWER: In this cohort of 54 young adult ICSI men, median sperm concentration, total sperm count and total motile sperm count were significantly lower than in spontaneously conceived peers. WHAT IS KNOWN ALREADY: The oldest ICSI offspring cohort worldwide has recently reached adulthood. Hence, their reproductive health can now be investigated...
October 5, 2016: Human Reproduction
Julie Hamaide, Geert De Groof, Gwendolyn Van Steenkiste, Ben Jeurissen, Johan Van Audekerke, Maarten Naeyaert, Lisbeth Van Ruijssevelt, Charlotte Cornil, Jan Sijbers, Marleen Verhoye, Annemie Van der Linden
Zebra finches are an excellent model to study the process of vocal learning, a complex socially-learned tool of communication that forms the basis of spoken human language. So far, structural investigation of the zebra finch brain has been performed ex vivo using invasive methods such as histology. These methods are highly specific, however, they strongly interfere with performing whole-brain analyses and exclude longitudinal studies aimed at establishing causal correlations between neuroplastic events and specific behavioral performances...
September 30, 2016: NeuroImage
Lars Peter Holst Andersen
The hormone, melatonin is produced with circadian rhythm by the pineal gland in humans. The melatonin rhythm provides an endogenous synchronizer, modulating e.g. blood pressure, body temperature, cortisol rhythm, sleep-awake-cycle, immune function and anti-oxidative defence. Interestingly, a number of experimental animal studies demonstrate significant dose-dependent anti-nociceptive effects of exogenous melatonin. Similarly, recent experimental- and clinical studies in humans indicate significant analgesic effects...
October 2016: Danish Medical Journal
Huiwei Zhang, Ping Wu, Sibylle I Ziegler, Yihui Guan, Yuetao Wang, Jingjie Ge, Markus Schwaiger, Sung-Cheng Huang, Chuantao Zuo, Stefan Förster, Kuangyu Shi
OBJECTIVES: In brain (18)F-FDG PET data intensity normalization is usually applied to control for unwanted factors confounding brain metabolism. However, it can be difficult to determine a proper intensity normalization region as a reference for the identification of abnormal metabolism in diseased brains. In neurodegenerative disorders, differentiating disease-related changes in brain metabolism from age-associated natural changes remains challenging. This study proposes a new data-driven method to identify proper intensity normalization regions in order to improve separation of age-associated natural changes from disease related changes in brain metabolism...
September 28, 2016: NeuroImage
Esma J Doğramacı, Giampiero Rossi-Fedele
BACKGROUND: The authors studied the effects of nonnutritive sucking behavior (NNSB) on malocclusions through a systematic review of association (etiology). TYPES OF STUDIES REVIEWED: The authors performed a 3-step search strategy, including electronic searches. Studies of healthy participants with a history of active or previous NNSB, for whom specific malocclusion outcomes had been assessed, were eligible for inclusion. The authors considered before-and-after studies, prospective and retrospective (longitudinal) studies, case-control studies, and analytical cross-sectional studies...
September 28, 2016: Journal of the American Dental Association
Shafaq Khairi, Babak Torabi Sagvand, Karen J Pulaski-Liebert, Nicholas A Tritos, Anne Klibanski, Lisa B Nachtigall
OBJECTIVES: The aim of this study was to evaluate the proportion of patients with acromegaly who remained on long-term lanreotide depot after completion of an open label multicenter phase III clinical trial (SALSA), compare symptom score at long-term follow-up with baseline and correlate these with individual longitudinal clinical outcomes. METHODS: Records of all subjects previously enrolled at the Massachusetts General Hospital site of SALSA were reviewed. Those who remained on lanreotide were interviewed and asked to complete a questionnaire that they had completed in SALSA in 2007 regarding their current symptomatology and injection side effects as well as to complete the Acromegaly Quality of life questionnaire...
September 28, 2016: Endocrine Practice
Jonas Esche, Simone Johner, Lijie Shi, Eckhard Schönau, Thomas Remer
CONTEXT: Diet can impact on bone strength via metabolic shifts in acid-base status. In contrast to the strongly diet-dependent biomarker urinary potential renal acid load (uPRAL), the amount of renally excreted citrate integrates nutritional and systemic influences on acid-base homeostasis with high citrate indicating preferential alkalization. OBJECTIVE: To examine the association between urinary citrate excretion and bone strength as well as long-term fracture risk...
September 27, 2016: Journal of Clinical Endocrinology and Metabolism
Janet F Jensen, Dorthe Overgaard, Morten H Bestle, Doris F Christensen, Ingrid Egerod
AIMS AND OBJECTIVES: To describe the patient experience of ICU recovery from a longitudinal perspective by analysing follow-up consultations at three time-points. BACKGROUND: After a stay in the intensive care unit, patients risk physical and psychological problems during recovery. Follow-up after intensive care has emerged to aid psychological recovery, and improve health-related quality of life. More insight is needed into the mechanisms of intensive care recovery...
September 26, 2016: Journal of Clinical Nursing
Liana S Leach, Carmel Poyser, Peter Butterworth
The established links between workplace bullying and poor mental health provide a prima facie reason to expect that workplace bullying increases the risk of suicidal ideation (thoughts) and behaviours. Until now, there has been no systematic summary of the available evidence. This systematic review summarises published studies reporting data on workplace bullying and suicidal ideation, or behaviour. The review sought to ascertain the nature of this association and highlight future research directions. 5 electronic databases were searched...
September 23, 2016: Occupational and Environmental Medicine
Hirokazu Tanaka, Jun Tomio, Takehiro Sugiyama, Yasuki Kobayashi
OBJECTIVE: To investigate the process quality of diabetes care provided to patients under universal health insurance coverage. RESEARCH DESIGN AND METHODS: Using claim data for 570 363 beneficiaries aged 20-69 years who were covered by Health Insurance Societies between April 2010 and March 2012, we identified patients with type 2 diabetes who made follow-up visits at least every 3 months in the first year (subject-identification year). We assessed patient adherence to follow-up visits in the second year (quality-reporting year), calculated the proportion of patients that completed routine examinations for glycemic control and complications, and evaluated associations between characteristics of patients and quality indicators using multivariable logistic regression models...
2016: BMJ Open Diabetes Research & Care
C K Wong, W N Levine, K Deo, R S Kesting, E A Mercer, G A Schram, B L Strang
BACKGROUND: In 1940s, it was proposed that frozen shoulder progresses through a self-limiting natural history of painful, stiff and recovery phases, leading to full recovery without treatment. However, clinical evidence of persistent limitations lasting for years contradicts this assumption. OBJECTIVES: To assess evidence for the natural history theory of frozen shoulder by examining: (1) progression through recovery phases, and (2) full resolution without treatment...
June 21, 2016: Physiotherapy
Alicia J Spittle, Jennifer L McGinley, Deanne Thompson, Ross Clark, Tara L FitzGerald, Benjamin F Mentiplay, Katherine J Lee, Joy E Olsen, Alice Burnett, Karli Treyvaud, Elisha Josev, Bonnie Alexander, Claire E Kelly, Lex W Doyle, Peter J Anderson, Jeanie Ly Cheong
INTRODUCTION: Motor impairments are one of the most frequently reported adverse neurodevelopmental consequences in children born < 30 weeks' gestation. Up to 15% of children born at < 30 weeks have cerebral palsy and an additional 50% have mild to severe motor impairment at school age. The first 5 years of life are critical for the development of fundamental motor skills. These skills form the basis for more complex skills that are required to competently and confidently participate in schooling, sporting and recreational activities...
October 2016: Journal of Physiotherapy
Laura-Jane E Smith, Ifrah Ali, Patrick Stone, Liam Smeeth, Jennifer K Quint
INTRODUCTION: People living with advanced chronic obstructive pulmonary disease (COPD) suffer from significant morbidity, reduced quality of life and high mortality, and are likely to benefit from many aspects of a palliative care approach. Prognostic estimates are a meaningful part of decision-making and better evidence for such estimates would facilitate advance care planning. We aim to provide quality evidence on known prognostic variables and scores which predict a prognosis in COPD of <12 months for use in the community...
September 15, 2016: BMJ Open
Steven A Branstetter, William J Horton, Melissa Mercincavage, Orfeu M Buxton
INTRODUCTION: Sleep disruption is common among smokers, however, extant studies primarily explore differences between smokers and nonsmokers. The time to smokers' first cigarette of the day (TTFC) after waking, a strong indicator of addiction severity, is inversely associated with numerous health outcomes. The present study tests the hypotheses that, in a representative sample of daily smokers, the severity of nicotine addiction is associated with shorter habitual sleep duration and excessive daytime sleepiness...
July 14, 2016: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
Erica B Stein, Peter S Liu, Ella A Kazerooni, Karen Barber, Matthew S Davenport
OBJECTIVE: The objective of our study was to reduce variation in image quality of orthogonal reformatted images generated from long-z-axis CT angiography (CTA) studies of the upper and lower extremities. SUBJECTS AND METHODS: Upper and lower extremity CTA studies were targeted at a single health care system. A correctly performed CTA examination was defined as one that met the following three criteria: Sagittal and coronal reformats were obtained, a high-resolution matrix greater than 512 × 512 was used, and reformatted images were available in a distance-measurable format...
September 9, 2016: AJR. American Journal of Roentgenology
Marie Crandall, Alexander Eastman, Pina Violano, Wendy Greene, Steven Allen, Ernie Block, A Britton Christmas, Andrew Dennis, Thomas Duncan, Shannon Foster, Stephanie Goldberg, Michael Hirsh, D'Andrea Joseph, Karen Lommel, Peter Pappas, William Shillinglaw
BACKGROUND: In the past decade, more than 300,000 people in the United States have died from firearm injuries. Our goal was to assess the effectiveness of two particular prevention strategies, restrictive licensing of firearms and concealed carry laws, on firearm-related injuries in the U.S. Restrictive licensing was defined to include denials of ownership for various offenses, such as performing background checks for domestic violence and felony convictions. Concealed carry laws allow licensed individuals to carry concealed weapons...
September 16, 2016: Journal of Trauma and Acute Care Surgery
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