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https://www.readbyqxmd.com/read/27919760/proton-therapy-present-and-future
#1
REVIEW
Radhe Mohan, David Grosshans
In principle, proton therapy offers a substantial clinical advantage over the conventional photon therapy. This is because of the unique depth-dose characteristics of protons, which can be exploited to achieve significant reductions in normal tissue doses proximal and distal to the target volume. These may, in turn, allow escalation of tumor doses, greater sparing of normal tissues, thus potentially improving local control and survival while at the same time reducing toxicity and improving quality of life. Protons, accelerated to therapeutic energies ranging from 70 to 250MeV, typically with a cyclotron or a synchrotron, are transported to the treatment room where they enter the treatment head mounted on a rotating gantry...
December 2, 2016: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/27917962/human-and-animal-health-surveys-among-pastoralists
#2
E Schelling, H Greter, H Kessely, M F Abakar, B N Ngandolo, L Crump, B Bold, J Kasymbekov, Z Baljinnyam, G Fokou, J Zinsstag, B Bonfoh, J Hattendorf, M Béchir
Valid human and livestock health surveys, including longitudinal follow-up, are feasible among mobile pastoralists and provide fundamental information to agencies for interventions that are responsive to realities and effective in addressing the needs of pastoralists. However, pastoralists are often excluded from studies, surveillance systems and health programmes. The occurrence of preventable and treatable diseases such as perinatal tetanus, measles and tuberculosis are indicative of limited access to health providers and information...
November 2016: Revue Scientifique et Technique
https://www.readbyqxmd.com/read/27913280/neuropsychological-functioning-and-chronic-methadone-use-a-systematic-review-and-meta-analysis
#3
REVIEW
A Baldacchino, M Armanyous, D J K Balfour, G Humphris, K Matthews
INTRODUCTION: There is a presumption that neurocognition is commonly impaired in chronic methadone exposed individuals (CM) when compared with healthy controls (HP). Additionally, it remains unclear if short term (<1year) abstinence (AP) is associated with an altered cognitive profile when compared with CM. METHOD: A random effect model approach was used on data assembled into the Comprehensive Meta-Analysis programme. Cohen's d effect sizes and a significance levels of p<0...
November 29, 2016: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/27908413/trace-element-and-cytokine-concentrations-in-patients-with-fibrodysplasia-ossificans-progressiva-fop-a-case-control-study
#4
Laura Hildebrand, Timo Gaber, Peter Kühnen, Rolf Morhart, Heinz Unterbörsch, Lutz Schomburg, Petra Seemann
Fibrodysplasia Ossificans Progressiva (FOP) is a rare inherited disease characterized by progressive heterotopic ossification. Disease onset, severity and symptoms vary between FOP patients, as does the frequency and activity of so-called flare-ups, during which tendons, ligaments, muscle and soft tissue are replaced by bone. Traumata, infections or other stressors are known inducers of flare-ups, and the hormone Activin A may be involved in disease activity; however, reliable biomarkers for FOP activity are missing, and the basal trace element and inflammatory state of patients are unknown...
January 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/27899397/chronic-obstructive-pulmonary-disease-and-the-risk-of-stroke-a-systematic-review-protocol
#5
Ann D Morgan, Chetna Sharma, Kieran J Rothnie, Jennifer K Quint
INTRODUCTION: There is good evidence to suggest that chronic obstructive pulmonary disease (COPD) increases the risk of ischaemic heart disease, in particular myocardial infarction (MI). The relationship between stroke and COPD, however, is not as well established, and studies conducted to date have generated conflicting results. METHODS AND ANALYSIS: MEDLINE and Embase will be searched for relevant articles using a prespecified search strategy. We will target observational studies conducted in the general population that employ either a longitudinal cohort or case-control study design to estimate ORs, HRs or incident rate ratios for the association between COPD and a subsequent first stroke...
November 29, 2016: BMJ Open
https://www.readbyqxmd.com/read/27896237/negative-religious-coping-positive-religious-coping-and-quality-of-life-among-hemodialysis-patients
#6
Zahra Taheri-Kharameh, Hadi Zamanian, Ali Montazeri, Azadeh Asgarian, Roya Esbiri
BACKGROUND: Religious coping is known as a main resource influencing how individuals cope with the complications and stressors of chronic disease. OBJECTIVES: The aim of this study was to assess the relationship between religious coping and quality of life among hemodialysis patients. METHODS: This cross-sectional study was conducted in Qom, Iran, from June 2012 to July 2013. Ninety-five end-stage renal disease (ESRD) patients undergoing hemodialysis were selected via the convenience sampling method...
November 2016: Nephro-urology Monthly
https://www.readbyqxmd.com/read/27894298/effect-of-continuity-of-care-on-health-related-quality-of-life-in-adult-patients-with-hypertension-a-cohort-study-in-china
#7
Ting Ye, Xiaowei Sun, Wenxi Tang, Yudong Miao, Yan Zhang, Liang Zhang
BACKGROUND: Continuity of care is widely considered a principle of primary care that decreases healthcare utilization and mortality. However, the effect of continuity of care on health-related quality of life (HRQoL) for adult patients with hypertension remains unclear. METHODS: To further evaluate the effect of continuity of care, we implemented a cohort study among hypertensive patients aged over 35 years (n = 1200) in six townships in Qianjiang District, Chongqing, China, between 2012 and 2014...
November 28, 2016: BMC Health Services Research
https://www.readbyqxmd.com/read/27893143/association-between-wic-enrollment-and-exclusive-breastfeeding-at-3-months-postpartum-among-low-income-mothers
#8
John Francescon, Zelalem T Haile, David Kling, Ilana Chertok
CONTEXT: Existing literature suggests participation in the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) in the prenatal and postnatal periods is associated with lower rates of breastfeeding among WIC-eligible mothers. However, minimal research has been published on the association between WIC enrollment and exclusive breastfeeding. OBJECTIVE: To examine the association between WIC exposure and exclusive breastfeeding at 3 months postpartum...
December 1, 2016: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/27881893/what-predicts-adolescent-delinquent-behavior-in-hong-kong-a-longitudinal-study-of-personal-and-family-factors
#9
Daniel T L Shek, Li Lin
Using four waves of data from Secondary 1 to Secondary 4 (N = 3328 students at Wave 1), this study examined the development of delinquent behavior and its relationships with economic disadvantage, family non-intactness, family quality of life (i.e., family functioning) and personal well-being (i.e., positive youth development) among Hong Kong adolescents. Individual growth curve models revealed that delinquent behavior increased during this period, and adolescents living in non-intact families (vs. intact families) reported higher initial levels of delinquent behavior while those living in poor families (vs...
2016: Social Indicators Research
https://www.readbyqxmd.com/read/27881145/evaluation-of-efficacy-and-efficiency-of-a-pragmatic-intervention-by-a-social-worker-to-support-informal-caregivers-of-elderly-patients-the-ice-study-study-protocol-for-a-randomized-controlled-trial
#10
Astrid Pozet, Catherine Lejeune, Magalie Bonnet, Sandrine Dabakuyo, Michèle Dion, Philippe Fagnoni, Maryse Gaimard, Geneviève Imbert, Virginie Nerich, Audrey Foubert, Morgane Chotard, Marie Bonin, Amélie Anota, Franck Bonnetain
BACKGROUND: Medical progress and the lifestyle modification have prolonged life expectancy, despite the development of chronic diseases. Support and care for older subjects are often provided by a network of informal caregivers composed of family, friends and neighbors, who are essential in helping older persons to continue living at home. It has been shown that the extent and diversity of informal tasks may jeopardize the physical, mental and social wellbeing of caregivers. METHODS/DESIGN: The aim of the Informal Carers of Elderly cohort is to define, through a longitudinal study, profiles of caregivers of older patients with a diagnosis of one of the following diseases: cancer (breast, prostate, colorectal), neurodegenerative diseases (Parkinson's disease, Alzheimer's disease and similar diseases), neurovascular diseases (stroke), sensory diseases (age-related macular degeneration (AMD)) and heart disease (heart failure)...
November 3, 2016: Trials
https://www.readbyqxmd.com/read/27868215/the-contribution-of-clinical-and-psychosocial-factors-to-fatigue-in-182-patients-with-inflammatory-bowel-disease-a-cross-sectional-study
#11
M Artom, W Czuber-Dochan, J Sturt, T Murrells, C Norton
BACKGROUND: Fatigue is a frequently reported and predominant symptom experienced by patients with inflammatory bowel disease (IBD) and its impact has been associated with poorer quality of life (QoL). The complex interplay between disease-related variables and potentially modifiable psychosocial factors in IBD-fatigue has yet to be unravelled. AIM: To evaluate the contribution of clinical, sociodemographic and psychosocial factors to the severity and impact of IBD-fatigue and QoL...
November 20, 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27866090/relationship-between-anxiety-disorders-and-domains-of-health-related-quality-of-life-among-nigerians-with-breast-cancer
#12
Olamijulo Adedeji Fatiregun, Andrew Toyin Olagunju, Adebayo Rasheed Erinfolami, Olubunmi Ayodele Arogunmati, Omolara Amina Fatiregun, Joseph Dada Adeyemi
PURPOSE: Health Related Quality of life (HRQoL) is increasingly recognised as an important indicator of outcome and well-being in oncology care. We set out in this study to evaluate whether significant association exists between anxiety disorders (ADs) and HRQoL in breast cancer, such that any intervention addressing ADs would potentially improve HRQoL. METHODS: A cross sectional evaluation of 200 attendees of an oncology clinic was done using designed questionnaire to gather socio-demographic and clinical data...
November 17, 2016: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/27862826/mindfulness-based-interventions-for-adults-who-are-overweight-or-obese-a-meta-analysis-of-physical-and-psychological-health-outcomes
#13
REVIEW
Jeffrey M Rogers, Madeleine Ferrari, Kylie Mosely, Cathryne P Lang, Leah Brennan
OBJECTIVE: The aim of this study was to evaluate the impact of mindfulness-based interventions on psychological and physical health outcomes in adults who are overweight or obese. METHODS: We searched 14 electronic databases for randomized controlled trials and prospective cohort studies that met eligibility criteria. Comprehensive Meta-analysis software was used to compute the effect size estimate Hedge's g. RESULTS: Fifteen studies measuring post-treatment outcomes of mindfulness-based interventions in 560 individuals were identified...
November 11, 2016: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27862265/mode-of-delivery-and-long-term-health-related-quality-of-life-outcomes-a-prospective-population-based-study
#14
Stavros Petrou, Sung Wook Kim, Penny McParland, Elaine M Boyle
BACKGROUND: Relatively little is known about the effects of mode of delivery on long-term health-related quality-of-life outcomes. Furthermore, no previous study has expressed these outcomes in preference-based (utility) metrics. METHODS: The study population comprised 2,161 mothers recruited from a prospective population-based study in the East Midlands of England encompassing live births and stillbirths between 32(+0) and 36(+6) weeks' gestation and a sample of term-born controls...
November 14, 2016: Birth
https://www.readbyqxmd.com/read/27859530/evaluation-of-the-outcomes-of-care-of-nurse-led-continence-care-clinics-for-chinese-patients-with-lower-urinary-tract-symptoms-a-two-year-prospective-longitudinal-study
#15
Weng Yee Chin, Edmond P H Choi, Eric Y F Wan, Anca K C Chan, Karina H Y Chan, Cindy L K Lam
AIM: To evaluate the 24-month outcomes of a nurse-led continence care service for Chinese primary care patients with lower urinary tract symptoms. BACKGROUND: Most studies evaluating the outcomes of continence care services have had short follow-up durations with limited knowledge on whether benefits are sustained beyond 12 months. DESIGN: 24-month cohort study. METHODS: Two comparison groups were recruited: (1) Patients with lower urinary tract symptoms attending a nurse-led community-based continence care programme; (2) Primary care patients with lower urinary tract symptoms identified by screening, receiving usual medical care...
November 11, 2016: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/27853130/health-related-quality-of-life-and-functional-outcomes-in-short-stem-versus-standard-stem-total-hip-arthroplasty-an-18-month-follow-up-cohort-study
#16
Brandon Michael Henry, Waldemar Wrażeń, Leif Hynnekleiv, Michał Kłosiński, Przemysław A Pękała, Ewa Kucharska, Edward B Golec, Krzysztof A Tomaszewski, Maria Pąchalska
BACKGROUND Osteoarthritis (OA) progressively produces symptoms and disability that may significantly reduce health-related quality of life (HRQoL). Total hip arthroplasty (THA) is an important treatment for symptomatic OA. An alternative to standard-stem THA for younger patients is short-stem THA. The aim of this study was to investigate potential HRQoL and functional outcome differences between these patient groups to provide additional data that will be clinically useful in the decision making between the types of prosthesis...
November 17, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27836316/effectiveness-of-reduction-maneuvers-in-the-treatment-of-nursemaid-s-elbow-a-systematic-review-and-meta-analysis
#17
REVIEW
Rens Bexkens, Frederic J Washburn, Denise Eygendaal, Michel P J van den Bekerom, Luke S Oh
BACKGROUND/AIM: Nursemaid's elbow usually occurs in young children when longitudinal traction is placed on the arm. Several manipulative maneuvers have been described, although, the most effective treatment technique is yet unclear. The aim of this systematic review and meta-analysis was to compare the two most commonly performed maneuvers (supination-flexion and hyperpronation) in the treatment of nursemaid's elbow. METHODS: A literature search was performed in PubMed, Embase, and Cochrane databases to identify randomized controlled trials comparing supination-flexion and hyperpronation...
November 2, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27816041/nicotine-dependence-and-sleep-quality-in-young-adults
#18
E N Dugas, M P Sylvestre, E K O'Loughlin, J Brunet, L Kakinami, E Constantin, J O'Loughlin
INTRODUCTION: More cigarette smokers report poor sleep quality than non-smokers, but the association between nicotine dependence (ND) and sleep quality has not been well-characterized. The objective of this study was to describe the associations among frequency and intensity of cigarette smoking, ND symptoms, and sleep quality in young adults. METHODS: Data on past-year smoking frequency, number of cigarettes smoked in the past month, five ND indicators (i.e., withdrawal, craving, self-medication symptoms, mFTQ, ICD-10 criteria for tobacco dependence), and sleep quality (measured with the Pittsburgh Sleep Quality Index (PSQI)) were collected in 2011-12 in self-report questionnaires completed by 405 young adult smokers (mean age 24 (0...
February 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/27798838/sexual-quality-of-life-and-aging-a-prospective-study-of-a-nationally-representative-sample
#19
Miriam K Forbes, Nicholas R Eaton, Robert F Krueger
Unlike other life domains, sexual quality of life (SQoL) has a negative relationship with age. This study disentangled the effect of age in this relationship from confounding sociocultural influences (e.g., the period of time in which data were collected, and cohort differences) and aimed to understand the roles of other sexual domains (i.e., frequency, perceived control, thought and effort invested in sex, and number of sexual partners). We analyzed data from the longitudinal Midlife in the United States study (n = 6,278; age range 20-93), which were collected between 1995 and 2013...
October 31, 2016: Journal of Sex Research
https://www.readbyqxmd.com/read/27787619/trajectories-of-depression-in-adults-with-newly-diagnosed-type-1-diabetes-results-from-the-german-multicenter-diabetes-cohort-study
#20
Hanna Kampling, Frank Petrak, Erik Farin, Bernd Kulzer, Stephan Herpertz, Oskar Mittag
AIMS/HYPOTHESIS: There is a paucity of longitudinal data on type 1 diabetes and depression, especially in adults. The present study prospectively analysed trajectories of depressive symptoms in adults during the first 5 years of living with type 1 diabetes. We aimed to identify distinct trajectories of depressive symptoms and to examine how they affect diabetes outcome. METHODS: We reanalysed data from a prospective multicentre observational cohort study including 313 adults with newly diagnosed type 1 diabetes...
January 2017: Diabetologia
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