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longitudinal study data quality control

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https://www.readbyqxmd.com/read/28444084/effects-of-zinc-supplementation-on-fatigue-and-quality-of-life-in-patients-with-colorectal-cancer
#1
Sofia Miranda de Figueiredo Ribeiro, Camila Bitu Moreno Braga, Fernanda Maris Peria, Edson Zangiacomi Martinez, José Joaquim Ribeiro da Rocha, Selma Freire Carvalho Cunha
Objective: To investigate the effects of oral zinc supplementation on fatigue intensity and quality of life of patients during chemotherapy for colorectal cancer. Methods: A prospective, randomized, double-blinded, placebo-controlled study was conducted with 24 patients on chemotherapy for colorectal adenocarcinoma in a tertiary care public hospital. The study patients received zinc capsules 35mg (Zinc Group, n=10) or placebo (Placebo Group, n=14) orally, twice daily (70mg/day), for 16 weeks, from the immediate postoperative period to the fourth chemotherapy cycle...
January 2017: Einstein
https://www.readbyqxmd.com/read/28440892/the-effect-of-adult-early-warning-systems-education-on-nurses-knowledge-confidence-and-clinical-performance-a-systematic-review
#2
REVIEW
Mohamad M Saab, Bridie McCarthy, Tom Andrews, Eileen Savage, Frances J Drummond, Nuala Walshe, Mary Forde, Dorothy Breen, Patrick Henn, Jonathan Drennan, Josephine Hegarty
AIMS: This review aims to determine the effect of adult Early Warning Systems education on nurses' knowledge, confidence and clinical performance. BACKGROUND: Early Warning Systems support timely identification of clinical deterioration and prevention of avoidable deaths. Several educational programmes have been designed to help nurses recognise and manage deteriorating patients. Little is known as to the effectiveness of these programmes. DESIGN: SYSTEMATIC REVIEW: DATA SOURCES: Academic Search Complete, CINAHL, MEDLINE, PsycINFO, PsycARTICLES, Psychology and Behavioral Science Collection, SocINDEX and the UK & Ireland Reference Centre, EMBASE, the Turning Research Into Practice database, the Cochrane Central Register of Controlled Trials (CENTRAL) and Grey Literature sources were searched between October - November 2015...
April 25, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28439076/practice-makes-perfect-self-reported-adherence-a-positive-marker-of-inhaler-technique-maintenance
#3
Elizabeth Azzi, Pamela Srour, Carol Armour, Cynthia Rand, Sinthia Bosnic-Anticevich
Poor inhaler technique and non-adherence to treatment are major problems in the management of asthma. Patients can be taught how to achieve good inhaler technique, however maintenance remains problematic, with 50% of patients unable to demonstrate correct technique. The aim of this study was to determine the clinical, patient-related and/or device-related factors that predict inhaler technique maintenance. Data from a quality-controlled longitudinal community care dataset was utilized. 238 patients using preventer medications where included...
April 24, 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/28422454/childhood-maltreatment-and-adulthood-poor-sleep-quality-a-longitudinal-study
#4
Amanuel Alemu Abajobir, Steve Kisely, Gail Williams, Lane Strathearn, Jake Moses Najman
BACKGROUND: Available evidence from cross-sectional studies suggests that childhood maltreatment may be associated with a range of sleep disorders. However, these studies have not controlled for potential individual, familial and environmental level confounders. AIM: To determine the association between childhood maltreatment and lower sleep quality, after adjusting for potential confounders. METHODS: Data for the present study are from a pre-birth cohort study of 3778 young adults (52...
April 19, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28409280/critical-issues-in-the-inclusion-of-genetic-and-epigenetic-information-in-prevention-and-intervention-trials
#5
Shawn J Latendresse, Rashelle Musci, Brion S Maher
Human genetic research in the past decade has generated a wealth of data from the genome-wide association scan era, much of which is catalogued and freely available. These data will typically test the relationship between a single nucleotide variant or polymorphism (SNP) and some outcome, disease, or trait. Ongoing investigations will yield a similar wealth of data regarding epigenetic phenomena. These data will typically test the relationship between DNA methylation at a single genomic location/region and some outcome...
April 13, 2017: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/28402013/the-relevance-of-context-in-understanding-health-literacy-skills-findings-from-a-qualitative-study
#6
Verna B McKenna, Jane Sixsmith, Margaret M Barry
BACKGROUND: Conceptualizing health literacy as a relational concept, which involves how individuals interact with complex health and social systems, requires a greater understanding of the context of people's health experiences. OBJECTIVES: To describe individuals' experiences of accessing, understanding, appraising and applying health information; explore the barriers and facilitators to using these skills; and to describe the experience of information exchange in health consultations...
April 12, 2017: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/28394022/limited-versus-full-sternotomy-for-aortic-valve-replacement
#7
REVIEW
Bilal H Kirmani, Sion G Jones, S C Malaisrie, Darryl A Chung, Richard Jnn Williams
BACKGROUND: Aortic valve disease is a common condition that is easily treatable with cardiac surgery. This is conventionally performed by opening the sternum longitudinally down the centre ("median sternotomy") and replacing the valve under cardiopulmonary bypass. Median sternotomy is generally well tolerated, but as less invasive options have become available, the efficacy of limited incisions has been called into question. In particular, the effects of reducing the visibility and surgical access has raised safety concerns with regards to the placement of cannulae, venting of the heart, epicardial wire placement, and de-airing of the heart at the end of the procedure...
April 10, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28389883/high-throughput-high-volume-nuclear-imaging-for-preclinical-in-vivo-compound-screening-%C3%A2
#8
Sven Macholl, Ciara M Finucane, Jacob Hesterman, Stephen J Mather, Rachel Pauplis, Deirdre Scully, Jane K Sosabowski, Erwan Jouannot
BACKGROUND: Preclinical single-photon emission computed tomography (SPECT)/CT imaging studies are hampered by low throughput, hence are found typically within small volume feasibility studies. Here, imaging and image analysis procedures are presented that allow profiling of a large volume of radiolabelled compounds within a reasonably short total study time. Particular emphasis was put on quality control (QC) and on fast and unbiased image analysis. METHODS: 2-3 His-tagged proteins were simultaneously radiolabelled by (99m)Tc-tricarbonyl methodology and injected intravenously (20 nmol/kg; 100 MBq; n = 3) into patient-derived xenograft (PDX) mouse models...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28384974/a-comparative-study-of-the-quality-of-apical-seal-in-resilon-epiphany-se-following-intra-canal-irrigation-with-17-edta-10-citric-acid-and-mtad-as-final-irrigants-a-dye-leakage-study-under-vacuum
#9
Saravana Karthikeyan Balasubramanian, Vidya Saraswathi, Nidambur Vasudev Ballal, Shashi Rashmi Acharya, J Sivakumar Sampath, Sandeep Singh
INTRODUCTION: Adequate apical sealing ability of the root canal filling material is an essential requisite for a successful endodontic therapy. Various endodontic irrigants are used for the removal of smear layer before obturating with a solid core material, thereby, reducing microleakage and improving apical seal. Resilon, a synthetic material was developed as an alternative to replace the conventional gutta-percha (standard root canal filling material) and traditional sealers for the obturation of endodontically treated teeth...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28366327/underutilization-of-the-mslt-in-sleepy-patients-with-a-short-onset-rem-period-soremp-in-the-sleep-clinic
#10
Alyssa Cairns, Richard Bogan
OBJECTIVE/BACKGROUND: A nocturnal sleep onset REM period (defined as REM onset latency ≤ 15 min; SOREMP) occurs rarely and research has shown that the phenomenon is specific for type 1 and 2 narcolepsy. However, little is known about the meaningfulness of the phenotype in general sleep clinic patients because those that exhibit the phenomenon often present with few traditional narcolepsy symptoms. As such, this study aimed to (1) evaluate the rate of eventual MSLT testing for those with a SOREMP on routine PSG when the phenomenon occurred in the absence of potential explanatory factors and (2) quantify the stability of the SOREMP phenotype...
April 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28364887/does-orthodontic-treatment-before-the-age-of-18%C3%A2-years-improve-oral-health-related-quality-of-life-a-systematic-review-and-meta-analysis
#11
REVIEW
Hanieh Javidi, Mario Vettore, Philip E Benson
INTRODUCTION: Orthodontics aims to improve oral health-related quality of life (OHRQoL). In this systematic review, we examined the evidence for changes in OHRQoL after orthodontic treatment for patients treated before they were 18 years old. METHODS: The participants were patients aged less than 18 years. The interventions were nonorthognathic and cleft orthodontic treatment. The comparisons were before and after orthodontic treatment, or nonorthodontic control...
April 2017: American Journal of Orthodontics and Dentofacial Orthopedics
https://www.readbyqxmd.com/read/28364871/oxidative-stress-and-frailty-a-systematic-review-and-synthesis-of-the-best-evidence
#12
REVIEW
Pinar Soysal, Ahmet Turan Isik, Andre F Carvalho, Brisa S Fernandes, Marco Solmi, Patricia Schofield, Nicola Veronese, Brendon Stubbs
OBJECTIVE: Oxidative stress (OS) is associated with accelerated aging. Previous studies have suggested a possible relationship between OS and frailty but this association remains unclear. We conducted a systematic review to investigate potential interactions between OS and frailty. METHODS: A systematic literature search of original reports providing data on 'OS and antioxidant' parameters and frailty was carried out across major electronic databases from inception until May 2016...
May 2017: Maturitas
https://www.readbyqxmd.com/read/28345787/non-motor-symptoms-and-quality-of-life-in-subjects-with-mild-parkinsonian-signs
#13
J Prasuhn, L Piskol, E-J Vollstedt, J Graf, A Schmidt, V Tadic, S Tunc, J Hampf, E Warrlich, C Bibergeil, J Hagenah, C Klein, M Kasten, N Brüggemann
BACKGROUND: Mild parkinsonian signs (MPS) are frequent in the elderly population and associated with the presence of risk markers for Parkinson's disease (PD). Both MPS and non-motor signs may be present in prodromal PD and may significantly impair quality of life (QoL). OBJECTIVE: To disentangle the contribution of motor impairment and extra-motor manifestations to QoL in subjects with MPS (n=63), manifest PD (n=69), disorders with motor symptoms due to non-neurodegenerative diseases (n=213) and healthy controls (n=258)...
March 27, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28334856/evaluating-the-effects-of-organizational-and-educational-interventions-on-adherence-to-clinical-practice-guidelines-in-a-low-resource-primary-care-setting-in-kenya
#14
Joseph R Egger, Kayla Stankevitz, Robert Korom, Philip Angwenyi, Brittney Sullivan, Jun Wang, Sonia Hatfield, Emma Smith, Karishma Popli, Jessica Gross
Background: Mid-level care providers serve as the backbone of primary care in many parts of sub-Saharan Africa. Despite this, research suggests that the quality and consistency of this care is uneven. This study assessed the degree to which a set of four simple, low-cost interventions could improve adherence to a set of clinical quality measures (CQMs) associated with four common health conditions seen in a resource-constrained primary care setting. Methods: A quasi-experimental, longitudinal study was carried out in three primary care clinics in Nairobi, Kenya from August 2014 to January, 2015...
March 15, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/28331330/work-family-conflict-as-a-mediator-between-occupational-stress-and-psychological-health-among-mental-health-nurses-in-japan
#15
Norio Sugawara, Kazuma Danjo, Hanako Furukori, Yasushi Sato, Tetsu Tomita, Akira Fujii, Taku Nakagami, Kazuyo Kitaoka, Norio Yasui-Furukori
BACKGROUND: Occupational stress among mental health nurses may affect their psychological health, resulting in reduced performance. To provide high-quality, sustainable nursing care, it is necessary to identify and control the factors associated with psychological health among mental health nurses. The purpose of this study was to examine the role of work-family conflict (WFC) in the well-known relationship between occupational stress and psychological health among mental health nurses in Japan...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28322278/early-life-adversity-and-telomere-length-a-meta-analysis
#16
K K Ridout, M Levandowski, S J Ridout, L Gantz, K Goonan, D Palermo, L H Price, A R Tyrka
Early adversity, in the form of abuse, neglect, socioeconomic status and other adverse experiences, is associated with poor physical and mental health outcomes. To understand the biologic mechanisms underlying these associations, studies have evaluated the relationship between early adversity and telomere length, a marker of cellular senescence. Such results have varied in regard to the size and significance of this relationship. Using meta-analytic techniques, we aimed to clarify the relationship between early adversity and telomere length while exploring factors affecting the association, including adversity type, timing and study design...
March 21, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28316591/predictors-of-quality-of-life-in-acromegaly-no-consensus-on-biochemical-parameters
#17
REVIEW
Victor J Geraedts, Cornelie D Andela, Günter K Stalla, Alberto M Pereira, Wouter R van Furth, Caroline Sievers, Nienke R Biermasz
BACKGROUND: Quality of life (QoL) in patients with acromegaly is reduced irrespective of disease state. The contributions of multifactorial determinants of QoL in several disease stages are presently not well known. OBJECTIVE: To systematically review predictors of QoL in acromegalic patients. METHODS: Main databases were systematically searched using predefined search terms for potentially relevant articles up to January 2017. Inclusion criteria included separate acromegaly cohort, non-hereditary acromegaly, QoL as study parameter with clearly described method of measurement and quantitative results, N ≥ 10 patients, article in English and adult patients only...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28316090/impaired-quality-of-life-in-patients-with-treated-acromegaly-despite-long-term-biochemically-stable-disease-results-from-a-5-years-prospective-study
#18
Nikolaos Kyriakakis, Julie Lynch, Stephen G Gilbey, Susan M Webb, Robert D Murray
OBJECTIVE: Patients with acromegaly demonstrate impaired quality of life (QoL), but data on long-term QoL changes in treated acromegaly are limited. This study evaluates and identifies factors that influence QoL in patients with long-term biochemical remission. DESIGN: The study consists of a cross-sectional arm comparing QoL between patients with treated and controlled acromegaly and healthy controls; and a longitudinal arm assessing QoL changes in patients with biochemically stable disease during 5...
March 18, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28314466/gc-ms-based-gestational-diabetes-mellitus-longitudinal-study-identification-of-2-and-3-hydroxybutyrate-as-potential-prognostic-biomarkers
#19
Danuta Dudzik, Marcin Zorawski, Mariusz Skotnicki, Wieslaw Zarzycki, Antonia García, Santiago Angulo, M Paz Lorenzo, Coral Barbas, M Pilar Ramos
Gestational Diabetes Mellitus (GDM) causes severe short- and long-term complications for the mother, fetus and neonate, including type 2-diabetes (T2DM) later in life. In this pilot study, GC-Q/MS analysis was applied for plasma metabolomics fingerprinting of 24 healthy and 24 women with GDM at different stages of gestation (second and third trimester) and postpartum (one and three months). Multivariate (unsupervised and supervised) statistical analysis was performed to investigate variance in the data, identify outliers and for unbiased assessment of data quality...
March 1, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28306169/economic-burden-of-relapsed-or-refractory-multiple-myeloma-results-from-an-international-trial
#20
Don Robinson, Robert Z Orlowski, Michael Stokes, Jianming He, Samuel Huse, Abhishek Chitnis, Britte Kranenburg, Annette Lam
OBJECTIVE: The direct cost of relapsed or refractory multiple myeloma (RRMM) is documented; indirect costs are being explored. Healthcare payers seek cost offsets from therapies that improve clinical outcomes but challenge budgets; employers seek lower absenteeism and better productivity. Study goals were to: 1) Identify direct and indirect economic factors of RRMM and, 2) Explore longitudinal relationships between clinical, economic, and health-related quality of life (HRQoL) assessments...
March 17, 2017: European Journal of Haematology
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