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Ei-Ichiro Takaoka, Jun Miyazaki, Hitoshi Ishikawa, Koji Kawai, Tomokazu Kimura, Ryutaro Ishitsuka, Takahiro Kojima, Reiko Kanuma, Daichi Takizawa, Toshiyuki Okumura, Hideyuki Sakurai, Hiroyuki Nishiyama
OBJECTIVE: We retrospectively elucidated the oncological outcomes, prognostic factors and toxicities of proton beam therapy in trimodal bladder-preserving therapy for muscle-invasive bladder cancer at our institution. METHODS: From 1990 to 2015, 70 patients with cT2-3N0M0 muscle-invasive bladder cancer underwent trimodal bladder-preserving therapy consisting of maximal transurethral resection of the bladder tumor, small pelvis photon irradiation, intra-arterial chemotherapy and proton beam therapy...
October 13, 2016: Japanese Journal of Clinical Oncology
H Ishikawa, T Saito, T Iizumi, D Takizawa, K Ohnishi, M Mizumoto, R Kanuma, K Tanaka, H Numajiri, T Aihara, N Fukumitsu, T Okumura, H Sakurai
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
(no author information available yet)
No abstract text is available yet for this article.
2016: Medical Letter on Drugs and Therapeutics
Yuji Kitahata, Tomohiro Kanuma, Masayuki Hayashi, Nobuyoshi Kobayashi, Koji Ozasa, Takato Kusakabe, Burcu Temizoz, Etsushi Kuroda, Hiroki Yamaue, Cevayir Coban, Takuya Yamamoto, Kouji Kobiyama, Taiki Aoshi, Ken J Ishii
Recent evidence suggest that a β-glucan derived from mushroom Schizophyllan(SPG) complexed with a humanized TLR9 agonistic CpG DNA, K3 (K3-SPG) is a promising vaccine adjuvant that induces robust CD8 T cell responses to co-administered antigen. However, it has not been investigated whether K3-SPG alone can act as an anti-cancer immunotherapeutic agent or not. Here, we demonstrate that intravenous injection of K3-SPG, but not CpG alone, is accumulated in the tumor microenvironment and triggered immunogenic cell death (ICD) of tumor cells by local induction of type-I interferon (IFN) as well as IL-12...
July 1, 2016: Oncotarget
Kouji Kobiyama, Burcu Temizoz, Tomohiro Kanuma, Koji Ozasa, Masatoshi Momota, Takuya Yamamoto, Taiki Aoshi, Etsushi Kuroda, Ken J Ishii
CpG oligodeoxynucleotide (ODN) is one of promising nucleic acid-based adjuvants. We recently improved its ability to enhance CD8(+) T-cell responses to coadministered protein antigen without conjugation or emulsion, by forming a nanoparticulate complex between CpG ODN (K3) and mushroom-derived β-glucan schizophyllan (SPG), namely K3-SPG. Here, we sought to elucidate the cellular immunological mechanisms by which K3-SPG induce such potent CD8(+) T-cell responses to coadministered antigen. By focusing on two DC subsets, plasmacytoid DCs and CD8α(+) DCs, as well as the secreted cytokines, IFN-α and IL-12, we found that K3-SPG strongly activates mouse plasmacytoid DCs to secrete IFN-α and CD8α(+) DCs to secrete IL-12, respectively...
May 2016: European Journal of Immunology
Matt Shirley
Sebelipase alfa (Kanuma™) is a recombinant human lysosomal acid lipase (LAL) developed by Synageva BioPharma Corp. (now Alexion Pharmaceuticals, Inc.) for long-term enzyme replacement therapy in patients with LAL deficiency. The agent, administered by intravenous infusion once weekly or once every other week, acts to replace the deficient enzyme activity in patients with LAL deficiency, reducing lysosomal lipid accumulation, and thereby improving disease-related abnormalities such as dyslipidaemia and liver abnormalities...
November 2015: Drugs
Shigeyuki Chaki, Toshiharu Shimazaki, Mariko Nishiguchi, Takeo Funakoshi, Michihiko Iijima, Akie Ito, Kosuke Kanuma, Yoshinori Sekiguchi
Melanin-concentrating hormone receptor 1 (MCH1 receptor) is known to be involved in the control of mood and stress, in addition to the regulation of feeding. Here, we report further evidence that the blockade of the MCH1 receptor exhibits antidepressant and anxiolytic-like effects in a variety of animal models using TASP0382650 and TASP0489838, newly synthesized MCH1 receptor antagonists, with different scaffolds. Both TASP0382650 and TASP0489838 exhibited high affinities for human MCH1 receptor with IC50 values of 7...
August 2015: Pharmacology, Biochemistry, and Behavior
Takafumi Otani, Ariel J Raigrodski, Lloyd Mancl, Ikuru Kanuma, Jacob Rosen
STATEMENT OF PROBLEM: Controlling tooth reduction for porcelain laminate veneers (PLVs) in fractions of millimeters is challenging. PURPOSE: The purpose of this study was to assess an automated robotic tooth preparation system for PLVs for accuracy and precision compared with conventional freehand tooth preparation. MATERIAL AND METHODS: Twenty maxillary central incisor tooth models were divided into 2 groups. Ten were assigned to a veneer preparation with a robotic arm according to preoperative preparation design-specific guidelines (experimental group)...
August 2015: Journal of Prosthetic Dentistry
Shengjiong Yang, Yingxin Zhao, Rongzhi Chen, Chuanping Feng, Zhenya Zhang, Zhongfang Lei, Yingnan Yang
In the present study, a novel tablet porous material (TPM) was developed from Kanuma clay (K-clay), corn starch, and calcium oxide. Laboratory-scale batch experiments were conducted to evaluate the phosphate adsorption capacity of TPM from aqueous solution. The adsorption isotherms, adsorption kinetics, phosphate recycling, and major factors such as temperature, pH, and dosage were investigated. The phosphate adsorption results fitted the Freundlich isotherm model very well, and the adsorption process was an endothermic and spontaneous reaction which could be described by a pseudo second-order kinetic model...
April 15, 2013: Journal of Colloid and Interface Science
Yingxin Zhao, Yingnan Yang, Shengjiong Yang, Qinghong Wang, Chuanping Feng, Zhenya Zhang
A novel ceramic adsorbent was developed to adsorb ammonium from high concentration ammonium contaminated wastewater. Typical gardening cultivation mediums in Japan-Kanuma clay and Akadama clay were used to synthesize the ceramic adsorbent. Static batch experiments were conducted to investigate the effect of various parameters such as contact time, initial ammonium concentration, adsorbent dosage, and competing cations during the ammonium adsorption process. The results revealed that the Freundlich isotherm model fitted better with the adsorption process than the Langmuir model, and the adsorption process was well described by pseudo-second-order kinetic model...
March 1, 2013: Journal of Colloid and Interface Science
Tomomi Yoshida, Takaaki Sano, Tatsuya Kanuma, Hiroshi Inoue, Teruko Itoh, Chiaki Yazaki, Mitsuo Obara, Toshio Fukuda
OBJECTIVE: This study evaluated the usefulness of p16(INK4a)/Ki-67 as a new biomarker in the diagnosis of human papillomavirus (HPV)-related cervical lesions. STUDY DESIGN: From 69 women with previous positive cytology, clinician-collected (CC) samples were obtained using a Cervex-Brush®. One month later, self-collected (SC) material was acquired using a Rovers® Viba-Brush. Liquid-based cytology specimens were prepared from both samples, and then the grades of squamous intraepithelial lesions (SIL) were determined; following immunostaining with CINtec® PLUS, HPV status was analyzed using a linear array...
2011: Acta Cytologica
Tomomi Yoshida, Takaaki Sano, Nami Takada, Tatsuya Kanuma, Hiroshi Inoue, Teruko Itoh, Chiaki Yazaki, Mitsuo Obara, Toshio Fukuda
OBJECTIVE: This study compared the usefulness of self-collected (SC) and clinician-collected (CC) materials for cervical cytology and human papillomavirus (HPV) genotyping. STUDY DESIGN: Fifty women with previous positive cytology and who were undergoing regular checkups were included in the study. CC samples were collected using a Cervex-Brush Combi with liquid-based cytology. One month later, SC material was acquired using the Rovers Viba-brush vaginal sampler, and fixed at home...
2011: Acta Cytologica
Nan Chen, Zhenya Zhang, Chuanping Feng, Miao Li, Rongzhi Chen, Norio Sugiura
Kanuma mud, a geomaterial, is used as an adsorbent for the removal of fluoride from water. The influences of contact time, solution pH, adsorbent dosage, initial fluoride concentration and co-existing ions were investigated by batch equilibration studies. The rate of adsorption was rapid with equilibrium being attained after about 2 h, and the maximum removal of fluoride was obtained at pH 5.0-8.0. The Freundlich isotherm model was found to represent the measured adsorption data well. The negative value of the thermodynamic parameter ΔG suggests the adsorption of fluoride by Kanuma mud was spontaneous, the endothermic nature of adsorption was confirmed by the positive ΔH value...
2010: Water Science and Technology: a Journal of the International Association on Water Pollution Research
Tomohiro Tamura, Tatsuya Kanuma, Tomoko Nakazato, Leri S Faried, Hiroshi Aoki, Takashi Minegishi
The clinical use of gene therapy requires tight regulation of the gene of interest and functional expression only when it is needed. Thus, it is necessary to develop ways of regulating functional gene expression with exogenous stimuli. Many regulatable systems are currently under development. For example, the tetracycline-dependent transcriptional switch has been successfully employed for in vivo preclinical applications. However, there are no examples of regulatable systems that have been employed in human clinical trials...
April 2010: International Journal of Oncology
Hidemichi Watari, Tatsuya Kanuma, Yoko Ohta, Mohamed Kamel Hassan, Takashi Mitamura, Masayoshi Hosaka, Takashi Minegishi, Noriaki Sakuragi
Overexpression of clusterin, an antiapoptotic molecule, has been reported to induce resistance to chemotherapy in a variety of cancer cell types. The aim of this study was to evaluate the significance of clusterin expression to predict response to platinum-based neoadjuvant chemotherapy and survival of patients with invasive cervical cancer who subsequently underwent radical hysterectomy. Biopsy specimens of invasive cervical cancer before neoadjuvant chemotherapy were obtained from 46 patients who subsequently underwent radical hysterectomy at Hokkaido University Hospital and Gunma University Hospital from 1994 to 2007...
September 2010: Pathology Oncology Research: POR
Kosuke Kanuma, Takeshi Aoki, Youichi Shimazaki
The glutamate hypothesis of schizophrenia suggests that hypofunction of N-methyl-D-aspartate (NMDA) receptors may be critical for schizophrenic symptoms; therefore, pharmacological approaches that enhance NMDA function may be beneficial for the treatment of schizophrenia. Several lines of evidence indicate that NMDA and metabotropic glutamate (mGlu) 5 receptors are closely associated signaling partners and that a selective mGlu5 receptor agonist might provide a viable approach for increasing NMDA receptor function in the treatment of schizophrenia...
January 2010: Recent Patents on CNS Drug Discovery
Graeme Semple, Thuy-Anh Tran, Bryan Kramer, Debbie Hsu, Sangdon Han, Juyi Choi, Pureza Vallar, Martin D Casper, Ning Zou, Erin K Hauser, William Thomsen, Kevin Whelan, Dipanjan Sengupta, Michael Morgan, Yoshinori Sekiguchi, Kosuke Kanuma, Shigeyuki Chaki, Andrew J Grottick
A series of pyrimidine analogues derived from ATC0175 were potent antagonists of human MCH-R1 in vitro. Significantly improved receptor selectivity was achieved with several analogues from this series, but no improvement in brain partitioning was noted. One example from this series was shown to inhibit food intake and decrease body weight in a chronic study. However no clear correlation between the pharmacodynamic effect and the pharmacokinetic data with respect to brain concentration was discernible leading us to conclude that the observed effect was most likely not due to interaction with the MCH-R1...
November 1, 2009: Bioorganic & Medicinal Chemistry Letters
Tomomi Yoshida, Takaaki Sano, Tetsunari Oyama, Tatsuya Kanuma, Toshio Fukuda
Adenosquamous carcinoma of the uterine cervix is a rare mixture of malignant squamous and glandular epithelial elements and accounts for approximately 10% of cervical carcinomas. The aims of the present study were to evaluate the prevalence, physical status, and viral load of HPV 16 and 18 in adenosquamous carcinoma. Formalin-fixed paraffin-embedded tissue samples from 20 cases of histologically diagnosed adenosquamous carcinoma were examined. The squamous and glandular components were separately microdissected and analyzed for their HPV DNA subtype, viral load, and physical status using real-time polymerase chain reaction (PCR)...
September 2009: Virchows Archiv: An International Journal of Pathology
Kazuto Nakamura, Hiroshi Aoki, Takashi Hirakawa, Tomomi Murata, Tatuya Kanuma, Takashi Minegishi
BACKGROUND: Compartment syndrome is a potentially devastating complication with possible permanent neuromuscular and kidney damage. CASE: A woman who had undergone radical hysterectomy with pelvic and paraaortic lymphadenectomy was diagnosed with compartment syndrome of the lower left limb. Thrombosis of the left common iliac artery was also found after emergency fasciotomy. CONCLUSION: Arterial thrombosis is less common than deep vein thrombosis during gynecologic operations, but the lithotomy position may cause insufficient arterial circulation in both the pelvis and legs...
August 2008: Obstetrics and Gynecology
Tomomi Yoshida, Takaaki Sano, Tatsuya Kanuma, Nobuo Owada, Shinji Sakurai, Toshio Fukuda, Takashi Nakajima
BACKGROUND: HPV L1 capsid protein is expressed together with the production of infectious viral particles, but its expression and relation to p16 expression, which has been a surrogate marker for human papilloma virus (HPV) infection in cervix, are little studied in cytology samples. The authors aimed to elucidate the relation between L1 capsid protein and p16 protein expressions in liquid-based samples from uterine cervical lesions. METHODS: Immunochemical analyses using antibodies against L1 capsid protein and p16 protein were carried out on cytological materials obtained from uterine cervical lesions of low-grade squamous intraepithelial lesions (LSILs), high-grade squamous intraepithelial lesions (HSILs), and squamous cell carcinomas (SCCs)...
April 25, 2008: Cancer
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