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Yung Liao, Ai Shibata, Kaori Ishii, Mohammad Javad Koohsari, Koichiro Oka
OBJECTIVES: This study examined cross-sectional and 2-year prospective associations of perceived and objectively measured environmental attributes with screen time among middle-aged Japanese adults. DESIGN: Prospective cohort study. SETTING: Nerima and Kanuma cities of Japan. PARTICIPANTS: Data were collected from adults aged 40-69 years living in two cities of Japan in 2011 (baseline: n=1011; 55.3±8.4 years) and again in 2013 (follow-up: n=533; 52...
March 2, 2018: BMJ Open
Yuji Masuta, Takuya Yamamoto, Yayoi Natsume-Kitatani, Tomohiro Kanuma, Eiko Moriishi, Kouji Kobiyama, Kenji Mizuguchi, Yasuhiro Yasutomi, Ken J Ishii
The priming, boosting, and restoration of memory cytotoxic CD8+ T lymphocytes by vaccination or immunotherapy in vivo is an area of active research. Particularly, nucleic acid-based compounds have attracted attention due to their ability to elicit strong Ag-specific CTL responses as a vaccine adjuvant. Nucleic acid-based compounds have been shown to act as anticancer monotherapeutic agents even without coadministration of cancer Ag(s); however, so far they have lacked efficacy in clinical trials. We recently developed a second-generation TLR9 agonist, a humanized CpG DNA (K3) complexed with schizophyllan (SPG), K3-SPG, a nonagonistic Dectin-1 ligand...
March 15, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
S Synoracki, S Kathemann, K W Schmid, H Jastrow, H A Baba
BACKGROUND AND CLINICAL SETTING: Lysosomal acid lipase deficiency is an autosomal recessive storage disease caused by mutations in the LIPA gene. The accumulation of cholesteryl esters and triglycerides in hepatocytes lead to hepatomegaly with progressive fibrosis and liver cirrhosis. Characteristically, patients have a hepatomegaly combined with high serum levels of cholesterol, LDL-cholesterol and in some cases triglyceride, whereas HDL-cholesterol is decreased. Histologically, hepatocytes show a microvesicular steatosis with typically ballooned Kupffer cells...
May 2018: Der Pathologe
Tomohiro Kanuma, Takuya Yamamoto, Kouji Kobiyama, Eiko Moriishi, Yuji Masuta, Takato Kusakabe, Koji Ozasa, Etsushi Kuroda, Nao Jounai, Ken J Ishii
DNA vaccines are attractive immunogens for priming humoral and cellular immune responses to the encoded Ag. However, their ability to induce Ag-specific CD8+ T cell responses requires improvement. Among the strategies for improving DNA vaccine immunogenicity are booster vaccinations, alternate vaccine formulations, electroporation, and genetic adjuvants, but few, such as extracellular vesicles (EVs), target natural Ag delivery systems. By focusing on CD63, a tetraspanin protein expressed on various cellular membranes, including EVs, we examined whether a DNA vaccine encoding an Ag fused to CD63 delivered into EVs would improve vaccine immunogenicity...
June 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
Etsushi Kuroda, Koji Ozasa, Burcu Temizoz, Keiichi Ohata, Christine X Koo, Tomohiro Kanuma, Takato Kusakabe, Shingo Kobari, Masanori Horie, Yasuo Morimoto, Saeko Nakajima, Kenji Kabashima, Steven F Ziegler, Yoichiro Iwakura, Wataru Ise, Tomohiro Kurosaki, Takahiro Nagatake, Jun Kunisawa, Naoki Takemura, Satoshi Uematsu, Masayuki Hayashi, Taiki Aoshi, Kouji Kobiyama, Cevayir Coban, Ken J Ishii
Particulate pollution is thought to function as an adjuvant that can induce allergic responses. However, the exact cell types and immunological factors that initiate the lung-specific immune responses are unclear. We found that upon intratracheal instillation, particulates such as aluminum salts and silica killed alveolar macrophages (AMs), which then released interleukin-1α (IL-1α) and caused inducible bronchus-associated lymphoid tissue (iBALT) formation in the lung. IL-1α release continued for up to 2 weeks after particulate exposure, and type-2 allergic immune responses were induced by the inhalation of antigen during IL-1α release and iBALT formation, even long after particulate instillation...
December 20, 2016: Immunity
James E Frampton
Sebelipase alfa (Kanuma®, Kanuma™), the first commercially available recombinant human lysosomal acid lipase (LAL), is approved in various countries worldwide, including those of the EU, the USA and Japan, as a long-term enzyme replacement therapy for patients diagnosed with LAL deficiency (LAL-D), an ultra-rare, autosomal recessive, progressive metabolic liver disease. In an ongoing study in nine infants presenting with early-onset LAL-D (Wolman disease), open-label treatment with sebelipase alfa significantly improved 1-year survival compared with historical controls...
December 2016: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
Kim Su, Emma Donaldson, Reena Sharma
Lysosomal acid lipase deficiency (LAL-D) is a rare disorder of cholesterol metabolism with an autosomal recessive mode of inheritance. The absence or deficiency of the LAL enzyme gives rise to pathological accumulation of cholesterol esters in various tissues. A severe LAL-D phenotype manifesting in infancy is associated with adrenal calcification and liver and gastrointestinal involvement with characteristic early mortality. LAL-D presenting in childhood and adulthood is associated with hepatomegaly, liver fibrosis, cirrhosis, and premature atherosclerosis...
2016: Application of Clinical Genetics
Ei-Ichiro Takaoka, Jun Miyazaki, Hitoshi Ishikawa, Koji Kawai, Tomokazu Kimura, Ryutaro Ishitsuka, Takahiro Kojima, Reiko Kanuma, Daichi Takizawa, Toshiyuki Okumura, Hideyuki Sakurai, Hiroyuki Nishiyama
OBJECTIVE: We retrospectively elucidated the oncological outcomes, prognostic factors and toxicities of proton beam therapy in trimodal bladder-preserving therapy for muscle-invasive bladder cancer at our institution. METHODS: From 1990 to 2015, 70 patients with cT2-3N0M0 muscle-invasive bladder cancer underwent trimodal bladder-preserving therapy consisting of maximal transurethral resection of the bladder tumor, small pelvis photon irradiation, intra-arterial chemotherapy and proton beam therapy...
January 2017: Japanese Journal of Clinical Oncology
H Ishikawa, T Saito, T Iizumi, D Takizawa, K Ohnishi, M Mizumoto, R Kanuma, K Tanaka, H Numajiri, T Aihara, N Fukumitsu, T Okumura, H Sakurai
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
(no author information available yet)
No abstract text is available yet for this article.
September 26, 2016: Medical Letter on Drugs and Therapeutics
Yuji Kitahata, Tomohiro Kanuma, Masayuki Hayashi, Nobuyoshi Kobayashi, Koji Ozasa, Takato Kusakabe, Burcu Temizoz, Etsushi Kuroda, Hiroki Yamaue, Cevayir Coban, Takuya Yamamoto, Kouji Kobiyama, Taiki Aoshi, Ken J Ishii
Recent evidence suggest that a β-glucan derived from mushroom Schizophyllan(SPG) complexed with a humanized TLR9 agonistic CpG DNA, K3 (K3-SPG) is a promising vaccine adjuvant that induces robust CD8 T cell responses to co-administered antigen. However, it has not been investigated whether K3-SPG alone can act as an anti-cancer immunotherapeutic agent or not. Here, we demonstrate that intravenous injection of K3-SPG, but not CpG alone, is accumulated in the tumor microenvironment and triggered immunogenic cell death (ICD) of tumor cells by local induction of type-I interferon (IFN) as well as IL-12...
August 2, 2016: Oncotarget
Kouji Kobiyama, Burcu Temizoz, Tomohiro Kanuma, Koji Ozasa, Masatoshi Momota, Takuya Yamamoto, Taiki Aoshi, Etsushi Kuroda, Ken J Ishii
CpG oligodeoxynucleotide (ODN) is one of promising nucleic acid-based adjuvants. We recently improved its ability to enhance CD8(+) T-cell responses to coadministered protein antigen without conjugation or emulsion, by forming a nanoparticulate complex between CpG ODN (K3) and mushroom-derived β-glucan schizophyllan (SPG), namely K3-SPG. Here, we sought to elucidate the cellular immunological mechanisms by which K3-SPG induce such potent CD8(+) T-cell responses to coadministered antigen. By focusing on two DC subsets, plasmacytoid DCs and CD8α(+) DCs, as well as the secreted cytokines, IFN-α and IL-12, we found that K3-SPG strongly activates mouse plasmacytoid DCs to secrete IFN-α and CD8α(+) DCs to secrete IL-12, respectively...
May 2016: European Journal of Immunology
Matt Shirley
Sebelipase alfa (Kanuma™) is a recombinant human lysosomal acid lipase (LAL) developed by Synageva BioPharma Corp. (now Alexion Pharmaceuticals, Inc.) for long-term enzyme replacement therapy in patients with LAL deficiency. The agent, administered by intravenous infusion once weekly or once every other week, acts to replace the deficient enzyme activity in patients with LAL deficiency, reducing lysosomal lipid accumulation, and thereby improving disease-related abnormalities such as dyslipidaemia and liver abnormalities...
November 2015: Drugs
Shigeyuki Chaki, Toshiharu Shimazaki, Mariko Nishiguchi, Takeo Funakoshi, Michihiko Iijima, Akie Ito, Kosuke Kanuma, Yoshinori Sekiguchi
Melanin-concentrating hormone receptor 1 (MCH1 receptor) is known to be involved in the control of mood and stress, in addition to the regulation of feeding. Here, we report further evidence that the blockade of the MCH1 receptor exhibits antidepressant and anxiolytic-like effects in a variety of animal models using TASP0382650 and TASP0489838, newly synthesized MCH1 receptor antagonists, with different scaffolds. Both TASP0382650 and TASP0489838 exhibited high affinities for human MCH1 receptor with IC50 values of 7...
August 2015: Pharmacology, Biochemistry, and Behavior
Takafumi Otani, Ariel J Raigrodski, Lloyd Mancl, Ikuru Kanuma, Jacob Rosen
STATEMENT OF PROBLEM: Controlling tooth reduction for porcelain laminate veneers (PLVs) in fractions of millimeters is challenging. PURPOSE: The purpose of this study was to assess an automated robotic tooth preparation system for PLVs for accuracy and precision compared with conventional freehand tooth preparation. MATERIAL AND METHODS: Twenty maxillary central incisor tooth models were divided into 2 groups. Ten were assigned to a veneer preparation with a robotic arm according to preoperative preparation design-specific guidelines (experimental group)...
August 2015: Journal of Prosthetic Dentistry
Shengjiong Yang, Yingxin Zhao, Rongzhi Chen, Chuanping Feng, Zhenya Zhang, Zhongfang Lei, Yingnan Yang
In the present study, a novel tablet porous material (TPM) was developed from Kanuma clay (K-clay), corn starch, and calcium oxide. Laboratory-scale batch experiments were conducted to evaluate the phosphate adsorption capacity of TPM from aqueous solution. The adsorption isotherms, adsorption kinetics, phosphate recycling, and major factors such as temperature, pH, and dosage were investigated. The phosphate adsorption results fitted the Freundlich isotherm model very well, and the adsorption process was an endothermic and spontaneous reaction which could be described by a pseudo second-order kinetic model...
April 15, 2013: Journal of Colloid and Interface Science
Yingxin Zhao, Yingnan Yang, Shengjiong Yang, Qinghong Wang, Chuanping Feng, Zhenya Zhang
A novel ceramic adsorbent was developed to adsorb ammonium from high concentration ammonium contaminated wastewater. Typical gardening cultivation mediums in Japan-Kanuma clay and Akadama clay were used to synthesize the ceramic adsorbent. Static batch experiments were conducted to investigate the effect of various parameters such as contact time, initial ammonium concentration, adsorbent dosage, and competing cations during the ammonium adsorption process. The results revealed that the Freundlich isotherm model fitted better with the adsorption process than the Langmuir model, and the adsorption process was well described by pseudo-second-order kinetic model...
March 1, 2013: Journal of Colloid and Interface Science
Tomomi Yoshida, Takaaki Sano, Tatsuya Kanuma, Hiroshi Inoue, Teruko Itoh, Chiaki Yazaki, Mitsuo Obara, Toshio Fukuda
OBJECTIVE: This study evaluated the usefulness of p16(INK4a)/Ki-67 as a new biomarker in the diagnosis of human papillomavirus (HPV)-related cervical lesions. STUDY DESIGN: From 69 women with previous positive cytology, clinician-collected (CC) samples were obtained using a Cervex-Brush®. One month later, self-collected (SC) material was acquired using a Rovers® Viba-Brush. Liquid-based cytology specimens were prepared from both samples, and then the grades of squamous intraepithelial lesions (SIL) were determined; following immunostaining with CINtec® PLUS, HPV status was analyzed using a linear array...
2011: Acta Cytologica
Tomomi Yoshida, Takaaki Sano, Nami Takada, Tatsuya Kanuma, Hiroshi Inoue, Teruko Itoh, Chiaki Yazaki, Mitsuo Obara, Toshio Fukuda
OBJECTIVE: This study compared the usefulness of self-collected (SC) and clinician-collected (CC) materials for cervical cytology and human papillomavirus (HPV) genotyping. STUDY DESIGN: Fifty women with previous positive cytology and who were undergoing regular checkups were included in the study. CC samples were collected using a Cervex-Brush Combi with liquid-based cytology. One month later, SC material was acquired using the Rovers Viba-brush vaginal sampler, and fixed at home...
2011: Acta Cytologica
Nan Chen, Zhenya Zhang, Chuanping Feng, Miao Li, Rongzhi Chen, Norio Sugiura
Kanuma mud, a geomaterial, is used as an adsorbent for the removal of fluoride from water. The influences of contact time, solution pH, adsorbent dosage, initial fluoride concentration and co-existing ions were investigated by batch equilibration studies. The rate of adsorption was rapid with equilibrium being attained after about 2 h, and the maximum removal of fluoride was obtained at pH 5.0-8.0. The Freundlich isotherm model was found to represent the measured adsorption data well. The negative value of the thermodynamic parameter ΔG suggests the adsorption of fluoride by Kanuma mud was spontaneous, the endothermic nature of adsorption was confirmed by the positive ΔH value...
2010: Water Science and Technology: a Journal of the International Association on Water Pollution Research
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