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Felix G Meinel, U Joseph Schoepf, Jacob C Townsend, Brian A Flowers, Lucas L Geyer, Ullrich Ebersberger, Aleksander W Krazinski, Wolfgang G Kunz, Kolja M Thierfelder, Deborah W Baker, Ashan M Khan, Valerian L Fernandes, Terrence X O'Brien
We aimed to determine the diagnostic yield and accuracy of coronary CT angiography (CCTA) in patients referred for invasive coronary angiography (ICA) based on clinical concern for coronary artery disease (CAD) and an abnormal nuclear stress myocardial perfusion imaging (MPI) study. We enrolled 100 patients (84 male, mean age 59.6 ± 8.9 years) with an abnormal MPI study and subsequent referral for ICA. Each patient underwent CCTA prior to ICA. We analyzed the prevalence of potentially obstructive CAD (≥50% stenosis) on CCTA and calculated the diagnostic accuracy of ≥50% stenosis on CCTA for the detection of clinically significant CAD on ICA (defined as any ≥70% stenosis or ≥50% left main stenosis)...
June 15, 2018: Scientific Reports
Mengmeng Yu, Zhigang Lu, Wenbin Li, Meng Wei, Jing Yan, Jiayin Zhang
AIMS: To study the diagnostic performance of the ratio of Duke jeopardy score (DJS) to the minimal lumen diameter (MLD) at coronary computed tomographic angiography (CCTA) and machine learning based CT-FFR for differentiating functionally significant from insignificant lesions, with reference to fractional flow reserve (FFR). METHODS AND RESULTS: Patients who underwent both coronary CTA and FFR measurement at invasive coronary angiography (ICA) within 2 weeks were retrospectively included in our study...
August 15, 2018: International Journal of Cardiology
Bouchra Habib Geryes, Raphael Calmon, Victoria Donciu, Diala Khraiche, Karine Warin-Fresse, Damien Bonnet, Nathalie Boddaert, Francesca Raimondi
OBJECTIVE: To demonstrate that the use of step-and-shoot (SAS) mode in paediatric cardiac CT angiography (CCTA) is possible at heart rates (HR) greater than 65 bpm, allowing low-dose acquisition with single-source 64-slices CT. METHODS: We retrospectively included 125 paediatric patients (0-6 years). CCTA was performed with SAS at diastolic phase in 31 patients (group D, HR < 65 bpm), at systolic phase in 45 patients (group S, HR ≥ 65 bpm) and with non-gated mode in 49 patients (group NG)...
May 2018: Physica Medica: PM
Zhenhua Tang
PURPOSE: This study was aimed to explore the feasibility of lower tube voltage, low volumes of contrast medium, and low flow injection in prospective electrocardiogram (ECG)-triggered high-pitch dual-source coronary computed tomography angiography (CCTA) for coronary artery imaging. MATERIAL AND METHODS: A total of 140 patients with body mass index (BMI) ranging from 18.5 to 24.3 kg/m2 and heart rate (HR) lower than 65 times/min underwent CCTA were divided randomly into two groups...
June 4, 2018: Echocardiography
Donghee Han, Sho Torii, Kazuyuki Yahagi, Fay Y Lin, Ji Hyun Lee, Asim Rizvi, Heidi Gransar, Mahn-Won Park, Hadi Mirhedayati Roudsari, Wijnand J Stuijfzand, Lohendran Baskaran, Bríain Ó Hartaigh, Hyung-Bok Park, Sang-Eun Lee, Zabiullah Ali, Robert Kutys, Hyuk-Jae Chang, James P Earls, David Fowler, Renu Virmani, James K Min
BACKGROUND AND AIMS: Recent advancements in coronary computed tomography angiography (CCTA) have allowed for the quantitative measurement of high-risk lipid rich plaque. Determination of the optimal threshold for Hounsfield units (HU) by CCTA for identifying lipid rich plaque remains unknown. We aimed to validate reliable cut-points of HU for quantitative assessment of lipid rich plaque. METHODS: 8 post-mortem sudden coronary death hearts were evaluated with CCTA and histologic analysis...
May 21, 2018: Atherosclerosis
Juhani Knuuti, Haitham Ballo, Luis Eduardo Juarez-Orozco, Antti Saraste, Philippe Kolh, Anne Wilhelmina Saskia Rutjes, Peter Jüni, Stephan Windecker, Jeroen J Bax, William Wijns
Aims: To determine the ranges of pre-test probability (PTP) of coronary artery disease (CAD) in which stress electrocardiogram (ECG), stress echocardiography, coronary computed tomography angiography (CCTA), single-photon emission computed tomography (SPECT), positron emission tomography (PET), and cardiac magnetic resonance (CMR) can reclassify patients into a post-test probability that defines (>85%) or excludes (<15%) anatomically (defined by visual evaluation of invasive coronary angiography [ICA]) and functionally (defined by a fractional flow reserve [FFR] ≤0...
May 29, 2018: European Heart Journal
Piotr J Slomka
No abstract text is available yet for this article.
May 5, 2018: Journal of Cardiovascular Computed Tomography
Chadi Ayoub, Leonard Kritharides, Yeung Yam, Li Chen, Alomgir Hossain, Stephan Achenbach, Mouaz H Al-Mallah, Daniele Andreini, Daniel S Berman, Matthew J Budoff, Filippo Cademartiri, Tracy Q Callister, Hyuk-Jae Chang, Kavitha Chinnaiyan, Ricardo C Cury, Augustin Delago, Allison Dunning, Gudrun Feuchtner, Millie Gomez, Heidi Gransar, Martin Hadamitzky, Joerg Hausleiter, Niree Hindoyan, Philipp A Kaufmann, Yong-Jin Kim, Jonathon Leipsic, Erica Maffei, Hugo Marques, Gianluca Pontone, Gilbert Raff, Ronen Rubinshtein, Leslee J Shaw, Todd C Villines, James K Min, Benjamin J W Chow
Extent of coronary atherosclerotic disease (CAD) burden on coronary computed tomography angiography (CCTA) as measured by segment involvement score (SIS) has a prognostic value. We sought to investigate the incremental prognostic value of 'age adjusted SIS' (aSIS), which may be a marker of premature atherosclerosis and vascular age. Consecutive patients were prospectively enrolled into the CONFIRM (Coronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicentre) multinational observational study...
May 24, 2018: Heart and Vessels
Elliot R McVeigh, Amir Pourmorteza, Michael Guttman, Veit Sandfort, Francisco Contijoch, Suhas Budhiraja, Zhennong Chen, David A Bluemke, Marcus Y Chen
BACKGROUND: CT SQUEEZ is a new automated technique to evaluate regional endocardial strain by tracking features on the endocardium from 4D cine CT data. The objective of this study was to measure the range of endocardial regional strain (RSCT ) values obtained with CT SQUEEZ in the normal human left ventricle (LV) from standard clinical 4D coronary CTA exams. METHODS: RSCT was measured over the heart cycle in 25 humans with normal LV function using cine CT from three vendors...
May 9, 2018: Journal of Cardiovascular Computed Tomography
Sara Reinschmidt, Teja Turk, Philip E Tarr, Roger Kouyos, Christoph Hauser, Patrick Schmid, Rainer Weber, Philipp Kaufmann, Ronny R Buechel, Helen Kovari
Background: Incidental findings on coronary computed tomography angiography (CCTA) have a great impact on the benefits and costs of testing for cardiovascular disease. The number of incidental findings might be increased in human immunodeficiency virus (HIV)-positive individuals compared with the general population. Data are limited regarding the association between incidental findings and HIV infection. Methods: We assessed the prevalence and factors associated with incidental findings among HIV-positive and HIV-negative participants ≥45 years undergoing CCTA...
May 2018: Open Forum Infectious Diseases
David J Maron, Judith S Hochman, Sean M O'Brien, Harmony R Reynolds, William E Boden, Gregg W Stone, Sripal Bangalore, John A Spertus, Daniel B Mark, Karen P Alexander, Leslee Shaw, Jeffrey S Berger, T Bruce Ferguson, David O Williams, Robert A Harrington, Yves Rosenberg
BACKGROUND: Prior trials comparing a strategy of optimal medical therapy with or without revascularization have not shown that revascularization reduces cardiovascular events in patients with stable ischemic heart disease (SIHD). However, those trials only included participants in whom coronary anatomy was known prior to randomization and did not include sufficient numbers of participants with significant ischemia. It remains unknown whether a routine invasive approach offers incremental value over a conservative approach with catheterization reserved for failure of medical therapy in patients with moderate or severe ischemia...
April 21, 2018: American Heart Journal
Gurpreet Singh, Subhi J Al'Aref, Marly Van Assen, Timothy Suyong Kim, Alexander van Rosendael, Kranthi K Kolli, Aeshita Dwivedi, Gabriel Maliakal, Mohit Pandey, Jing Wang, Virginie Do, Manasa Gummalla, Carlo N De Cecco, James K Min
Propelled by the synergy of the groundbreaking advancements in the ability to analyze high-dimensional datasets and the increasing availability of imaging and clinical data, machine learning (ML) is poised to transform the practice of cardiovascular medicine. Owing to the growing body of literature validating both the diagnostic performance as well as the prognostic implications of anatomic and physiologic findings, coronary computed tomography angiography (CCTA) is now a well-established non-invasive modality for the assessment of cardiovascular disease...
April 30, 2018: Journal of Cardiovascular Computed Tomography
Alexander R van Rosendael, Gabriel Maliakal, Kranthi K Kolli, Ashley Beecy, Subhi J Al'Aref, Aeshita Dwivedi, Gurpreet Singh, Mohit Panday, Amit Kumar, Xiaoyue Ma, Stephan Achenbach, Mouaz H Al-Mallah, Daniele Andreini, Jeroen J Bax, Daniel S Berman, Matthew J Budoff, Filippo Cademartiri, Tracy Q Callister, Hyuk-Jae Chang, Kavitha Chinnaiyan, Benjamin J W Chow, Ricardo C Cury, Augustin DeLago, Gudrun Feuchtner, Martin Hadamitzky, Joerg Hausleiter, Philipp A Kaufmann, Yong-Jin Kim, Jonathon A Leipsic, Erica Maffei, Hugo Marques, Gianluca Pontone, Gilbert L Raff, Ronen Rubinshtein, Leslee J Shaw, Todd C Villines, Heidi Gransar, Yao Lu, Erica C Jones, Jessica M Peña, Fay Y Lin, James K Min
INTRODUCTION: Machine learning (ML) is a field in computer science that demonstrated to effectively integrate clinical and imaging data for the creation of prognostic scores. The current study investigated whether a ML score, incorporating only the 16 segment coronary tree information derived from coronary computed tomography angiography (CCTA), provides enhanced risk stratification compared with current CCTA based risk scores. METHODS: From the multi-center CONFIRM registry, patients were included with complete CCTA risk score information and ≥3 year follow-up for myocardial infarction and death (primary endpoint)...
April 30, 2018: Journal of Cardiovascular Computed Tomography
Kazuhiro Osawa, Rine Nakanishi, Toru Miyoshi, Sina Rahmani, Indre Ceponiene, Negin Nezarat, Mitsuru Kanisawa, Hong Qi, Eranthi Jayawardena, Nicholas Kim, Hiroshi Ito, Matthew J Budoff
BACKGROUND: Increased arterial stiffness is reportedly associated with cardiac remodelling, including the left atrium and left ventricle, in middle-aged and older adults. However, little is known about this association in young adults. METHODS: In total, 73 patients (44 (60%) men) aged 25 to 45 years with suspected coronary artery disease were included in the analysis. The left atrial volume index (LAVI), left ventricular volume index (LVVI), and left ventricular mass index (LVMI) were measured using coronary computed tomography angiography (CCTA)...
April 26, 2018: Heart, Lung & Circulation
Mårten Sandstedt, Jakob De Geer, Lilian Henriksson, Jan Engvall, Magnus Janzon, Anders Persson, Joakim Alfredsson
Background Coronary computed tomography angiography (CCTA) is increasingly used to detect coronary artery disease (CAD), but long-term follow-up studies are still scarce. Purpose To evaluate the prognostic value of CCTA in patients with suspected CAD. Material and Methods A total of 1205 consecutive CCTA patients with chest pain were classified as normal coronary arteries, non-obstructive CAD, or obstructive CAD. The primary outcome was major adverse cardiac event (MACE), defined as a composite outcome including cardiac death, myocardial infarction, unstable angina pectoris, or late revascularization (after >90 days)...
January 1, 2018: Acta Radiologica
Fabíola Santos Gabriel, Luiz Flávio Galvão Gonçalves, Enaldo Vieira de Melo, Antônio Carlos Sobral Sousa, Ibraim Masciarelli Francisco Pinto, Sara Melo Macedo Santana, Carlos José Oliveira de Matos, Maria Júlia Silveira Souto, Flávio Mateus do Sacramento Conceição, Joselina Luzia Menezes Oliveira
BACKGROUND: In view of the high mortality for cardiovascular diseases, it has become necessary to stratify the main risk factors and to choose the correct diagnostic modality. Studies have demonstrated that a zero calcium score (CS) is characteristic of a low risk for cardiovascular events. However, the prevalence of individuals with coronary atherosclerotic plaques and zero CS is conflicting in the specialized literature. OBJECTIVE: To evaluate the frequency of patients with coronary atherosclerotic plaques, their degree of obstruction and associated factors in patients with zero CS and indication for coronary computed tomography angiography (CCTA)...
May 3, 2018: Arquivos Brasileiros de Cardiologia
Ping Li, Lei Xu, Lin Yang, Rui Wang, Jiang Hsieh, Zhonghua Sun, Zhanming Fan, Jonathon A Leipsic
The aim of this study was to investigate the use of de-blooming algorithm in coronary CT angiography (CCTA) for optimal evaluation of calcified plaques. Calcified plaques were simulated on a coronary vessel phantom and a cardiac motion phantom. Two convolution kernels, standard (STND) and high-definition standard (HD STND), were used for imaging reconstruction. A dedicated de-blooming algorithm was used for imaging processing. We found a smaller bias towards measurement of stenosis using the de-blooming algorithm (STND: bias 24...
May 2, 2018: Scientific Reports
Ernesto Di Cesare, Lucia Patriarca, Luca Panebianco, Federico Bruno, Pierpaolo Palumbo, Ester Cannizzaro, Alessandra Splendiani, Antonio Barile, Carlo Masciocchi
Cardiovascular disease is still one of the main causes of death and an early identification of coronary artery disease (CAD) remains the primary step in clinical management of patients with cardiovascular risk factor. Coronary computed tomography angiography (CCTA) has shown high sensitivity in CAD detection and could be helpful as screening method. The purpose of this study was to assess the prevalence of coronary artery disease detected by CCTA in asymptomatic patients with an intermediate risk of CAD. MATERIALS AND METHODS: We retrospectively selected 185 asymptomatic patients with an intermediate Framingan Risk Score (mean age was 62...
April 30, 2018: La Radiologia Medica
S Oebel, S Hamada, K Higashigaito, J von Spiczak, E Klotz, F Enseleit, R Hinzpeter, F Ruschitzka, R Manka, H Alkadhi
OBJECTIVES: We aimed to assess the diagnostic performance of a combined protocol with coronary computed tomography angiography (CCTA) and stress CT perfusion imaging (CTP) in heart transplant patients for comprehensive morphological and functional imaging. METHODS: In this prospective study, 13 patients undergoing routine follow-up 8±6 years after heart transplantation underwent CCTA and dynamic adenosine stress CTP using a third-generation dual-source CT scanner, cardiac magnetic resonance (MR) adenosine stress perfusion imaging at 1...
April 30, 2018: European Radiology
Moshrik Abd Alamir, Pamela Noack, Kristine H Jang, Jhanna A Moore, Roman Goldberg, Michael Poon
Routine use of CCTA to triage Emergency Department (ED) chest pain can reduce ED length of stay while providing accurate diagnoses. We evaluated the effectiveness of using Computer Aided Diagnosis in the triage of low to intermediate risk emergency chest pain patients with Coronary Computed Tomographic Angiography (CCTA). Using 64 and 320 slice CT scanners, we compared the diagnostic capability of computer aided diagnosis to human readers in 923 ED patients with chest pain. We calculated sensitivity, specificity, Positive Predictive Value and Negative Predictive Value for cases performed on each scanner...
April 25, 2018: International Journal of Cardiovascular Imaging
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