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Rongchong Huang, Xiantao Song, Haishan Zhang, Wen Tian, Zheng Huang, Xingwei Zhang, Junqing Yang, Dongfeng Zhang, Jian Wu, Lei Zhong, Henry H Ting
AIMS: Success of opening single (SOS)-comedy is a prospective multicenter study to compare the improvement in the decrease of myocardial viability by percutaneous coronary intervention (PCI) with that by optimal medical therapy (OMT) alone in patients with chronic total occlusion (CTO) of a single coronary artery. METHODS AND RESULTS: The risks and the benefits of both options (PCI and OMT) were listed in a CTO decision aid (DA). Eligible participants detected by invasive coronary angiography (ICA) or coronary computed tomography angiography (CCTA) were divided into PCI or OMT groups according to patients' choice after shared-decision making process with DA...
April 2018: Medicine (Baltimore)
Daniele Andreini, Fay Y Lin, Asim Rizvi, Iksung Cho, Ran Heo, Gianluca Pontone, Antonio L Bartorelli, Saima Mushtaq, Todd C Villines, Patricia Carrascosa, Byoung Wook Choi, Stephen Bloom, Han Wei, Yan Xing, Dan Gebow, Heidi Gransar, Hyuk-Jae Chang, Jonathon Leipsic, James K Min
OBJECTIVE: Motion artifact can reduce the diagnostic accuracy of coronary CT angiography (CCTA) for coronary artery disease (CAD). The purpose of this study was to compare the diagnostic performance of an algorithm dedicated to correcting coronary motion artifact with the performance of standard reconstruction methods in a prospective international multicenter study. SUBJECTS AND METHODS: Patients referred for clinically indicated invasive coronary angiography (ICA) for suspected CAD prospectively underwent an investigational CCTA examination free from heart rate-lowering medications before they underwent ICA...
April 18, 2018: AJR. American Journal of Roentgenology
Wassim Mosleh, Ali Sheikh, Zaid Said, Mohamed A Abdel-Aal, Siri Gadde, Tanvi Shah, Michael F Wilson, Hiroko Beck, Chee Kim, Umesh C Sharma
BACKGROUND: Atrial fibrillation (AF) is a growing financial burden on the healthcare system. Cardiac computed tomographic angiography (CCTA) is needed for pulmonary vein mapping before AF ablation (AFA). CCTA has shown to be an alternative to transesophageal echocardiogram (TEE) to rule-out left atrial appendage thrombus (LAAT) pre-AFA. We aim to examine the safety, cost-effectiveness, and time-efficiency of utilizing CCTA alone to rule out LAAT before AFA. METHODS: We prospectively screened patients with paroxysmal AF undergoing cryoablation...
April 17, 2018: Pacing and Clinical Electrophysiology: PACE
Yuanliang Xie, Xiang Wang, Wei Xie, Faxiang Chen, Shubo Gao, Yikai Xu
PURPOSE: Myocardial bridges (MB) have traditionally been considered a benign condition, but recent studies have demonstrated that the clinical complications can be dangerous. The transluminal attenuation gradient (TAG) obtained from coronary computed tomography angiography (CCTA) data (Retrospective ECG-triggered method) has been used in detecting significant stenosis in coronary artery caused by atherosclerosis. Contrast opacification difference (COD) was the parameters calculated as the change between attenuation of mural artery and the median attenuation of presumptive vessel segment; it was evaluated along with TAGstandardized (TAGs) and MB length for predicting MB with systolic compression (MB-SC) in patients diagnosed as MB in left anterior descending coronary artery (LAD) by CCTA or invasive coronary angiograph (ICA)...
April 17, 2018: Surgical and Radiologic Anatomy: SRA
Dominik C Benz, Lara Gaemperli, Christoph Gräni, Elia von Felten, Andreas A Giannopoulos, Michael Messerli, Ronny R Buechel, Oliver Gaemperli, Aju P Pazhenkottil, Philipp A Kaufmann
BACKGROUND: Although randomized trials have provided evidence for invasive fractional flow reserve to guide revascularization, evidence for non-invasive imaging is less well established. The present study investigated whether hybrid coronary computed tomography (CCTA)/single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) can identify patients who benefit from early revascularization compared to medical therapy. METHODS: This retrospective study consists of 414 patients referred for evaluation of known or suspected coronary artery disease (CAD) with CCTA/SPECT hybrid imaging...
June 15, 2018: International Journal of Cardiology
Mohamad Jihad Mansour, Wael AlJaroudi, Omar Hamoui, Sarah Chaaban, Elie Chammas
BACKGROUND: Exercise stress echocardiography (SE) is commonly used for diagnosing coronary artery disease (CAD). The use of quantitative echocardiographic measures such as strain imaging is expected to improve the sensitivity of conventional SE which relies on the visual diagnosis of wall-motion abnormalities (WMAs). This study is set to demonstrate the added value of resting and exercise strain analysis to detect underlying microangiopathy and inducible myocardial ischemia during a resting and SE in comparison with the results of coronary computed tomographic angiogram (CCTA)...
April 12, 2018: Echocardiography
Linn Andelius, Martin Bødtker Mortensen, Bjarne Linde Nørgaard, Jawdat Abdulla
Aim: To clarify the potential role of coronary computed tomographic angiography (CCTA) in assessing the remodelling impact of statin therapy on plaque burden and compositions. Methods and results: A systematic literature review and meta-analysis were conducted to examine the effect of statin therapy on different plaque volumes assessed by serial CCTA. Twelve studies were included with a mean (±standard deviation) follow-up period of 14.5 ± 9.5 months. Data on plaque volume were pooled using weighted mean difference method...
March 30, 2018: European Heart Journal Cardiovascular Imaging
Kenzo Uzu, Hiromasa Otake, Gilwoo Choi, Takayoshi Toba, Hyun Jin Kim, Arjun Rou, Michiel Schaap, Leo Grady, Masahito Kawata, Toshiro Shinke, Charles Anthony Taylor, Ken-Ichi Hirata
AIMS: To evaluate the accuracy of minimal lumen area (MLA) by coronary computed tomography angiography (cCTA) and its impact on fractional flow reserve (FFRCT). METHODS AND RESULTS: Fifty-seven patients (118 lesions, 72 vessels) who underwent cCTA and optical coherence tomography (OCT) were enrolled. OCT and cCTA were co-registered and MLAs were measured with both modalities. FFROCT was calculated using OCT-updated models with cCTA-based lumen geometry replaced by OCT-derived geometry...
April 3, 2018: EuroIntervention
Viktoria Muster, Markus Wallner, Albrecht Schmidt, Martin Kapl, Friederike von Lewinski, Peter Rainer, Pia Reittner, Manfred Tillich, Peter Brader, Dieter Hm Szolar, Dirk von Lewinski
Objective This study was performed to determine whether add-on oral ivabradine in patients treated with beta blockers 1 hour before coronary computed tomographic angiography (CCTA) is effective in lowering the heart rate and thus improving CCTA quality. Methods In this single-center cohort study, the data of 294 patients referred for ambulant CCTA were retrospectively screened. Patients with an initial heart rate of ≥75 bpm (n = 112) were pretreated with either a combination of bisoprolol and ivabradine or with bisoprolol alone...
January 1, 2018: Journal of International Medical Research
Andrea Igoren Guaricci, Valentina Lorenzoni, Marco Guglielmo, Saima Mushtaq, Giuseppe Muscogiuri, Filippo Cademartiri, Mark Rabbat, Daniele Andreini, Gaetano Serviddio, Nicola Gaibazzi, Mauro Pepi, Gianluca Pontone
BACKGROUD: The aim of the study was to evaluate the incremental prognostic benefit of carotid artery disease and subclinical coronary artery disease (CAD) features in addition to clinical evaluation in a asymptomatic population. METHODS: Over a six-year period, 10-year-FRS together with carotid ultrasound (CUS) and coronary computed tomography angiography (CCTA) were evaluated for the prediction of major adverse cardiac events (MACE). RESULTS: We enrolled 517 consecutive asymptomatic patients (63% male, 64±10 years of age, 17...
March 31, 2018: Clinical Cardiology
Takanori Masuda, Yoshinori Funama, Takeshi Nakaura, Tomoyasu Satou, Tomokazu Okimoto, Yukari Yamashita, Naoyuki Imada, Kazuo Awai
RATIONALE AND OBJECTIVES: We compared the radiation dose and diagnostic accuracy on 120- and 100-kVp coronary computed tomography angiography (CCTA) scans whose contrast-to-noise ratio (CNR) was the same. MATERIALS AND METHODS: We studied 1311 coronary artery segments from 100 patients. For 120-kVp scans, the targeted image level was set at 25 Hounsfield units (HU). For 100-kVp scans, the targeted noise level was set at 30 HU to obtain the same CNR as at 120 kVp...
March 26, 2018: Academic Radiology
Philip E Tarr, Bruno Ledergerber, Alexandra Calmy, Thanh Doco-Lecompte, Alex Marzel, Rainer Weber, Philipp A Kaufmann, René Nkoulou, Ronny R Buechel, Helen Kovari
Aims: HIV-positive persons have increased cardiovascular event rates but data on the prevalence of subclinical atherosclerosis compared with HIV-negative persons are not uniform. We assessed subclinical atherosclerosis utilizing coronary artery calcium (CAC) scoring and coronary computed tomography angiography (CCTA) in 428 HIV-positive participants of the Swiss HIV Cohort Study and 276 HIV-negative controls concurrently referred for clinically indicated CCTA. Methods and results: We assessed the association of HIV infection, cardiovascular risk profile, and HIV-related factors with subclinical atherosclerosis in univariable and multivariable analyses...
March 24, 2018: European Heart Journal
Fujimoto Shinichiro, Andreas A Giannopoulos, Kumamaru K Kanako, Rie Matsumori, Etsuro Kato, Yuko Kawaguchi, Kazuhisa Takamura, Katsumi Miyauchi, Frank J Rybicki, Hiroyuki Daida, Dimitris Mitsouras
OBJECTIVE: Results of the use of the Transluminal Attenuation Gradient(TAG) at coronary CT angiography (CCTA) to predict haemodynamically significant disease vary widely. This study tested whether diagnostic performance of TAG to predict FFR<0.8 is improved when applied separately to subsets of coronary arteries that carry similar physiologic flow. METHODS: Twenty-eight patients with 64×0.5 mm CCTA and invasive FFR in ≥1 major coronary artery were retrospectively evaluated...
March 28, 2018: British Journal of Radiology
Lingtong Min, Qi Tian, Xudong Lu, Jiye An, Huilong Duan
BACKGROUND: Clinical data registry is designed to collect and manage information about the practices and outcomes of a patient population for improving the quality and safety of care and facilitating novel researches. Semantic interoperability is a challenge when integrating the data from more than one clinical data registry. The openEHR approach can represent the information and knowledge semantics by multi-level modeling, and it advocates the use of collaborative modeling to facilitate reusing existing archetypes with consistent semantics so as to be a potential solution to improve the semantic interoperability...
March 22, 2018: BMC Medical Informatics and Decision Making
Hee Yeong Kim, Hwan Seok Yong, Eung Ju Kim, Eun-Young Kang, Bo Kyoung Seo
INTRODUCTION: This study aimed to evaluate the value of transluminal attenuation gradient (TAG) of stress coronary computed tomography angiography (CCTA), using a wide-area detector CT in patients with coronary artery disease, compared to stress perfusion cardiac magnetic resonance (CMR) imaging. METHODS: This prospective study from May 2012 to January 2015 included 21 patients with moderate coronary stenosis on invasive coronary angiography. All patients underwent adenosine stress single-shot CCTA with a rest CCTA scan using a wide-area detector CT...
January 2018: Cardiovascular Journal of Africa
Rine Nakanishi, Sethuraman Sankaran, Leo Grady, Jenifer Malpeso, Razik Yousfi, Kazuhiro Osawa, Indre Ceponiene, Negin Nazarat, Sina Rahmani, Kendall Kissel, Eranthi Jayawardena, Christopher Dailing, Christopher Zarins, Bon-Kwon Koo, James K Min, Charles A Taylor, Matthew J Budoff
OBJECTIVES: Our goal was to evaluate the efficacy of a fully automated method for assessing the image quality (IQ) of coronary computed tomography angiography (CCTA). METHODS: The machine learning method was trained using 75 CCTA studies by mapping features (noise, contrast, misregistration scores, and un-interpretability index) to an IQ score based on manual ground truth data. The automated method was validated on a set of 50 CCTA studies and subsequently tested on a new set of 172 CCTA studies against visual IQ scores on a 5-point Likert scale...
March 23, 2018: European Radiology
Hidenobu Takagi, Ryoichi Tanaka, Kyohei Nagata, Ryo Ninomiya, Kazumasa Arakita, Joanne D Schuijf, Kunihiro Yoshioka
PURPOSE: Recently, ultra-high-resolution computed tomography (U-HRCT) with a 0.25 mm × 128-row detector was introduced. The purpose of this study was to evaluate the diagnostic performance of coronary CT angiography (CCTA) using U-HRCT. METHODS: This retrospective study included 38 consecutive patients with suspected coronary artery disease (CAD) who underwent CCTA with U-HRCT followed by invasive coronary angiography (ICA). Per-segment diameter stenosis was calculated...
April 2018: European Journal of Radiology
Moritz H Albrecht, Matthew W Bickford, U Joseph Schoepf, Christian Tesche, Domenico De Santis, Marwen Eid, Brian E Jacobs, Taylor M Duguay, Bernhard T Schmidt, Christian Canstein, Akos Varga-Szemes, Doris Leithner, Simon Martin, Thomas J Vogl, Carlo N De Cecco
PURPOSE: To investigate the effect of an iterative beam-hardening correction algorithm (iBHC) on artifact reduction and image quality in coronary CT angiography (cCTA) with low tube voltage. MATERIAL AND METHODS: Thirty-six patients (17 male, mean age, 57.3 ± 14.5 years) were prospectively enrolled in this IRB-approved study and underwent 70-kV cCTA using a third-generation dual-source CT scanner. Images were reconstructed using a standard algorithm (Bv36) both with and without the iBHC technique...
April 2018: European Journal of Radiology
Edmund K Kerut, Michael Turner
Coronary computed tomography angiography (CCTA) has been an established noninvasive method for detection of coronary artery disease (CAD). Although CCTA has had a high sensitivity and negative predictive value for CAD detection, specificity for obstructive CAD has been relatively low, partly due to coronary calcium, imaging artifacts, and other factors leading to an overestimation of stenosis severity. A relatively new noninvasive method of calculation of fractional flow reserve (FFR) using CCTA (FFRCT ) data has been developed...
March 22, 2018: Echocardiography
Marietta Garmer, Marc Bonsels, Frauke Metz, Oliver Klein-Wiele, Bodo Brandts, Dietrich Grönemeyer
PURPOSE: To investigate whether the presence of endocardial leads has an impact on image quality in coronary computed tomography angiography (CCTA), when current technique is employed using a 320-row computed tomography and iterative reconstruction. MATERIALS AND METHODS: CCTA was performed in 1641 patients, from these we identified 51 patients (study group) with endocardial leads and 51 matched partners (control group) without endocardial leads. Noise was determined in the ascending aorta and the left ventricle; signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were determined in the left and right coronary artery...
March 2, 2018: Clinical Imaging
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