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https://www.readbyqxmd.com/read/29031220/effects-of-glyphosate-based-herbicide-on-pintado-da-amaz%C3%A3-nia-hematology-histological-aspects-metabolic-parameters-and-genotoxic-potential
#1
Fernando Rafael de Moura, Ritane Rose da Silva Lima, Ana Paula Simões da Cunha, Patrícia da Costa Marisco, Danilo Henrique Aguiar, Marina Mariko Sugui, Adilson Paulo Sinhorin, Valéria Dornelles Gindri Sinhorin
Roundup Original(®) is an herbicide widely used in Mato Grosso's agriculture and it may contamine water bodies, being an unforeseen xenobiotic to aquatic organisms, particularly fish. This study investigated the effects on the hybrid fish jundiara (Leiarius marmoratus×Pseudoplatystoma reticulatum) of an environmentally relevant exposure to this herbicide. Glucose levels in liver, muscle and plasma decreased after exposure to 1.357mgL(-1) of Roundup Original(®) (glyphosate nominal concentration), while glycogen levels reduced in liver and muscle for different times...
September 29, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29027957/peroxisomal-2-hydroxyacyl-coa-lyase-is-involved-in-endogenous-biosynthesis-of-heptadecanoic-acid
#2
Benjamin Jenkins, Evelyn de Schryver, Paul P Van Veldhoven, Albert Koulman
Circulating heptadecanoic acid (C17:0) is reported to be a pathology risk/prognosis biomarker and a dietary biomarker. This pathology relationship has been shown to be reliably predictive even when independent of dietary contributions, suggesting that the endogenous biosynthesis of C17:0 is related to the pathological aetiology. Little is known about C17:0 biosynthesis, which tissues contribute to the circulating levels, and how C17:0 is related to pathology. Hacl1+/- mice were mated to obtain Hacl1-/- and Hacl1+/+ control mice...
October 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29027371/differential-proteomic-analysis-of-dimethylnitrosamine-dmn-induced-liver-fibrosis
#3
Xiujie Liu, Rongji Dai, Ming Ke, Imran Suheryani, Weiwei Meng, Yulin Deng
Liver fibrosis is a common pathological feature of many chronic liver diseases. To characterize the entire panorama of proteome changes in DMN-induced liver fibrosis, iTRAQ-based differential proteomic analysis was performed with DMN-induced liver fibrosis rats. A total of 4155 confidently identified proteins were found, with 365 proteins showing significant changes (fold changes of >1.5 or < 0.67, P < 0.05). In metabolic activation, proteins assigned to drug metabolism enzymes (e.g., CYP2D1) changed, suggesting that the liver protection mechanism was activated to relieve DMN toxicity...
October 13, 2017: Proteomics
https://www.readbyqxmd.com/read/29027308/animal-models-for-analyzing-metabolic-syndrome-associated-liver-diseases
#4
REVIEW
Koichi Tsuneyama, Kazuchika Nishitsuji, Minoru Matsumoto, Tomoko Kobayashi, Yuki Morimoto, Takaaki Tsunematsu, Hirohisa Ogawa
Metabolic syndrome (MS) is a worldwide healthcare issue and a dominant risk factor for the development of incurable diseases affecting the entire body. The hepatic manifestations of MS include nonalcoholic fatty liver disease (NAFLD) and its progressive variant, nonalcoholic steatohepatitis (NASH). NASH is known to progress to liver cirrhosis and hepatocellular carcinoma (HCC). Excellent animal models for determining the mechanism of pathogenesis and establishing therapeutic treatment of NASH/HCC are strongly required worldwide...
October 12, 2017: Pathology International
https://www.readbyqxmd.com/read/29027235/low-dose-ct-for-the-detection-and-classification-of-metastatic-liver-lesions-results-of-the-2016-low-dose-ct-grand-challenge
#5
Cynthia H McCollough, Adam C Bartley, Rickey E Carter, Baiyu Chen, Tammy A Drees, Phillip Edwards, David R Holmes, Alice E Huang, Farhana Khan, Shuai Leng, Kyle L McMillan, Gregory J Michalak, Kristina M Nunez, Lifeng Yu, Joel G Fletcher
PURPOSE: Using common datasets, to estimate and compare the diagnostic performance of image-based denoising techniques or iterative reconstruction algorithms for the task of detecting hepatic metastases. METHODS: Datasets from contrast-enhanced CT scans of the liver were provided to participants in an NIH-, AAPM- and Mayo Clinic-sponsored Low Dose CT Grand Challenge. Training data included full-dose and quarter-dose scans of the ACR CT accreditation phantom and 10 patient examinations; both images and projections were provided in the training data...
October 2017: Medical Physics
https://www.readbyqxmd.com/read/29026167/the-proteasome-inhibitor-bortezomib-attenuates-renal-fibrosis-in-mice-via-the-suppression-of-tgf-%C3%AE-1
#6
Moko Zeniya, Takayasu Mori, Naofumi Yui, Naohiro Nomura, Shintaro Mandai, Kiyoshi Isobe, Motoko Chiga, Eisei Sohara, Tatemitsu Rai, Shinichi Uchida
Kidney fibrosis and fibrogenesis significantly exacerbate chronic kidney disease (CKD) progression and are essential therapeutic targets. Bortezomib (BZM) is a proteasome inhibitor used for the treatment of multiple myeloma (MM). Several studies have demonstrated that BZM attenuates renal impairment in patients with MM, although this effect is generally considered to be the result of MM remission. Recently, several studies on BZM reported anti-fibrotic effects on liver and skin in experimental animal models...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29025383/repair-of-bile-duct-injury-with-autologous-vein-graft-and-stent
#7
Bin Xie, Haiping Luo, Xinglong Yang, Yanping Zhao, Chongwu He, Xiaobin Wan, Zhitao Xu, Xingwei Yu, Wubo Liu, Qiang Liu
OBJECTIVES: We investigated the effects of autologous vein transplant on bile duct injury repair, through observation of the hepatic and biliary system tissue morphology changes and animal survival after bile duct injury repair. MATERIALS AND METHODS: Rabbits were equally divided into groups. Group A had cholecystectomy and common bile duct resection (length of 0.5 cm), transplant of an autologous vein (length of 0.5 cm), and stent implant. Group B had cholecystectomy and common bile duct resection (length of 1...
October 12, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29025321/rutin-ameliorates-oxidative-stress-and-preserves-hepatic-and-renal-functions-following-exposure-to-cadmium-and-ethanol
#8
Sunny O Abarikwu, Rex-Clovis Njoku, Chiamaka J Lawrence, Iniobong A Charles, Jude C Ikewuchi
CONTEXT: Rutin (RUT) is an antioxidant flavonoid with well-known metal chelating potentials. OBJECTIVE: This study was designed to evaluate the protective effects of RUT against cadmium (Cd) + ethanol (EtOH)-induced hepatic and renal toxicity in rats. MATERIALS AND METHODS: Wistar rats were treated with Cd (50 mg/kg) alone or in combination with EtOH (5 mg/kg) and RUT (25, 50 and 100 mg/kg) for 15 days. After treatment, the liver, kidney and serum were removed for biochemical assays by spectrophotometric methods...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29024054/multifunctional-nanohybrid-based-on-porous-silicon-nanoparticles-gold-nanoparticles-and-acetalated-dextran-for-liver-regeneration-and-acute-liver-failure-theranostics
#9
Zehua Liu, Yunzhan Li, Wei Li, Chen Xiao, Dongfei Liu, Chao Dong, Ming Zhang, Ermei Mäkilä, Marianna Kemell, Jarno Salonen, Jouni T Hirvonen, Hongbo Zhang, Dawang Zhou, Xianming Deng, Hélder A Santos
Herein, a novel nanohybrid based on porous silicon, gold nanoparticles (Au NPs), and acetalated dextran (DPSi/DAu@AcDEX) is reported to encapsulate and deliver one drug and increase the computer tomography (CT) signal for acute-liver-failure (ALF) theranostics. A microfluidic-assisted method is used to co-encapsulate different NPs in a single step. By alternating the surface properties of different NPs and by modulating the composition of the organic phase, both PSi and Au NPs are effectively encapsulated into the polymer matrix simultaneously, thus further achieving a multifunctional application...
October 11, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29023812/polycystic-liver-disease-hepatic-venous-outflow-obstruction-lesions-of-the-non-cystic-parenchyma-have-major-consequences
#10
Louise Barbier, Maxime Ronot, Béatrice Aussilhou, François Cauchy, Claire Francoz, Prof Valérie Vilgrain, Olivier Soubrane, Valérie Paradis, Jacques Belghiti
BACKGROUND: In patients with polycystic liver disease, development of cysts induces hepatic venous outflow obstruction (HVOO) and parenchymal modifications, challenging the paradigm of a normal non-cystic liver parenchyma. The aims were to reappraise the pathology of the non-cystic parenchyma, by focusing on HVOO lesions; and to investigate the association with outflow obstruction at imaging and perioperative course after liver resection. METHODS: This is a retrospective study conducted in one tertiary center between 1993 and 2014...
October 10, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29023811/placental-growth-factor-inhibition-targets-pulmonary-angiogenesis-and-represents-a-novel-therapy-for-hepatopulmonary-syndrome-in-mice
#11
Sarah Raevens, Anja Geerts, Annelies Paridaens, Sander Lefere, Xavier Verhelst, Anne Hoorens, Jo Van Dorpe, Tania Maes, Ken R Bracke, Christophe Casteleyn, Bart Jonckx, Thomas Horvatits, Valentin Fuhrmann, Hans Van Vlierberghe, Christophe Van Steenkiste, Lindsey Devisscher, Isabelle Colle
Hepatopulmonary syndrome (HPS) is a severe complication of cirrhosis with increased risk of mortality. Pulmonary microvascular alterations are key features of HPS, but underlying mechanisms are incompletely understood, and studies on HPS are limited to rats. Placental growth factor (PlGF), a pro-angiogenic molecule that is selectively involved in pathological angiogenesis, may play an important role in HPS development, however, its role has never been investigated. In this study, we validated an HPS model by common bile duct ligation (CBDL) in mice, investigated the kinetic changes in pulmonary angiogenesis and inflammation during HPS development, and provide evidence for a novel therapeutic strategy by targeting pathological angiogenesis...
October 10, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29023687/a-guide-for-effective-anatomical-vascularization-studies-useful-ex%C3%A2-vivo-methods-for-both-ct-and-mri-imaging-before-dissection
#12
Yohann Renard, Gabriela Hossu, Bailiang Chen, Marine Krebs, Marc Labrousse, Manuela Perez
The objective of this study was to develop a simple and useful injection protocol for imaging cadaveric vascularization and dissection. Mixtures of contrast agent and cast product should provide adequate contrast for two types of ex vivo imaging (MRI and CT) and should harden to allow gross dissection of the injected structures. We tested the most popular contrast agents and cast products, and selected the optimal mixture composition based on their availability and ease of use. All mixtures were first tested in vitro to adjust dilution parameters of each contrast agent and to fine-tune MR imaging acquisition sequences...
October 11, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/29023152/primary-hepatic-neoplasms-of-vascular-origin-key-imaging-features-and-differential-diagnoses-with-radiology-pathology-correlation
#13
Hailey Hye-In Choi, Maria A Manning, Anupamjit K Mehrotra, Sean Wagner, Reena C Jha
OBJECTIVE: This article describes, illustrates, and correlates imaging and pathologic features of primary vascular mesenchymal neoplasms of the liver, which arise from the vascular endothelium and perivascular epithelioid cells. CONCLUSION: Familiarity with the spectrum of benign, malignant-potential and malignant vascular neoplasms, and nonneoplastic mimickers allows consideration in the differential diagnosis of enhancing hepatic masses. Understanding relevant pathologic features facilitates recognition of key imaging features, specifically dynamic contrast enhancement patterns on CT and MRI, which provide a useful classification system...
October 12, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29022266/cardiac-aging-benefits-of-exercise-nrf2-activation-and-antioxidant-signaling
#14
Madhusudhanan Narasimhan, Namakkal-Soorappan Rajasekaran
Cardiovascular dysfunction and heart failure associated with aging not only impairs the cardiac function but also the quality of life eventually decreasing the life expectancy of the elderly. Notably, cardiac tissue can prematurely age under certain conditions such as genetic mutation, persistent redox stress and overload, aberrant molecular signaling, DNA damage, telomere attrition, and other pathological insults. While cardiovascular-related morbidity and mortality is on the rise and remains a global health threat, there has been only little to moderate improvements in its medical management...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29022092/unique-manifestations-of-biliary-atresia-provide-new-immunological-insight-into-its-etiopathogenesis
#15
REVIEW
Toshihiro Muraji, Haruo Ohtani, Satoshi Ieiri
Biliary atresia (BA) is a unique cholestatic disease of newborns with a background of exaggerated immune response in the liver of unknown mechanism. Three hypotheses have been proposed; autoimmune type of cholangiopathy triggered by virus infection, graft-versus-host disease type of immune-mediated disease associated with maternal microchimerism and ductal plate malformation theory. Researchers on virus infection theory have experimentally explored immune process causing cholangiopathy on murine models of this disease, while in maternal microchimerism hypothesis were detected maternal cells in the BA patients' liver, of which roles are yet to be determined...
October 11, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/29022011/placental-extract-ameliorates-non-alcoholic-steatohepatitis-nash-by-exerting-protective-effects-on-endothelial-cells
#16
Akihiro Yamauchi, Akiko Kamiyoshi, Teruhide Koyama, Nobuyoshi Iinuma, Shumpei Yamaguchi, Hiroyuki Miyazaki, Eiichi Hirano, Taiichi Kaku, Takayuki Shindo
Non-alcoholic steatohepatitis (NASH) is a severe form of fatty liver disease that is defined by the presence of inflammation and fibrosis, ultimately leading to cirrhosis and hepatocellular carcinoma. Treatment with human placental extract (HPE) reportedly ameliorates the hepatic injury. We evaluated the effect of HPE treatment in a mouse model of NASH. In the methione- and choline-deficient (MCD) diet-induced liver injury model, fibrosis started from regions adjacent to the sinusoids. We administered the MCD diet with high-salt loading (8% NaCl in the drinking water) to mice deficient in the vasoprotective molecule RAMP2 for 5 weeks, with or without HPE...
September 2017: Heliyon
https://www.readbyqxmd.com/read/29021374/reactive-oxygen-species-regulate-the-inflammatory-function-of-nkt-cells-through-promyelocytic-leukemia-zinc-finger
#17
Yeung-Hyen Kim, Ajay Kumar, Cheong-Hee Chang, Kalyani Pyaram
Reactive oxygen species (ROS) are byproducts of aerobic metabolism and contribute to both physiological and pathological conditions as second messengers. ROS are essential for activation of T cells, but how ROS influence NKT cells is unknown. In the present study, we investigated the role of ROS in NKT cell function. We found that NKT cells, but not CD4 or CD8 T cells, have dramatically high ROS in the spleen and liver of mice but not in the thymus or adipose tissues. Accordingly, ROS-high NKT cells exhibited increased susceptibility and apoptotic cell death with oxidative stress...
October 11, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29020416/fructose-metabolism-cardiometabolic-risk-and-the-epidemic-of-coronary-artery-disease
#18
Peter Mirtschink, Cholsoon Jang, Zoltan Arany, Wilhelm Krek
Despite strong indications that increased consumption of added sugars correlates with greater risks of developing cardiometabolic syndrome (CMS) and cardiovascular disease (CVD), independent of the caloric intake, the worldwide sugar consumption remains high. In considering the negative health impact of overconsumption of dietary sugars, increased attention is recently being given to the role of the fructose component of high-sugar foods in driving CMS. The primary organs capable of metabolizing fructose include liver, small intestine, and kidneys...
September 7, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29020055/danshen-protects-against-early-stage-alcoholic-liver-disease-in-mice-via-inducing-ppar%C3%AE-activation-and-subsequent-4-hne-degradation
#19
Lei Ding, Like Wo, Zhongyan Du, Lihua Tang, Zhenyuan Song, Xiaobing Dou
Alcoholic liver disease (ALD) is a type of chronic liver disease caused by long-term heavy ethanol consumption. Danshen is one of the most commonly used substances in traditional Chinese medicine and has been widely used for the treatment of various diseases, and most frequently, the ALD. The current study aims to determine the potential beneficial effect of Danshen administration on ALD and to clarify the underlying molecular mechanisms. Danshen administration improved liver pathologies of ALD, attenuated alcohol-induced increment of hepatic 4-Hydroxynonenal (4-HNE) formation, and prevented hepatic Peroxisome proliferators activated receptor alpha (PPARα) suppression in response to chronic alcohol consumption...
2017: PloS One
https://www.readbyqxmd.com/read/29019132/rapid-2d-dige-proteomic-analysis-of-mouse-liver
#20
Shotaro Kamata, Isao Ishii
Several years have passed since LC-MS(/MS) became the mainstream for proteomic analysis; however, conventional 2D DIGE (two-dimensional difference gel electrophoresis) continues to be an important technology that enables rapid and direct visualization of hundreds to thousands of proteins and their quantitative analyses. We can get global proteomic views using 2D DIGE within 3 days, and then identify proteins with differential expression levels using MALDI-TOF/MS and MASCOT search engine within a week. Here, we describe our routine 2D DIGE proteomic analysis of the liver isolated from mice in pathological conditions...
2018: Methods in Molecular Biology
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