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https://www.readbyqxmd.com/read/27531790/-clinical-study-of-cytomegalovirus-infection-and-preemptive-therapy-after-allogenic-hematopoietic-stem-cell-transplantation
#1
Wei-Jie Cao, Ding-Ming Wan, Li Li, Chong Wang, Su-Ping Zhang, Chang-Feng Liu, Xing-Sheng Xie, Hui Sun
OBJECTIVE: To analyze the clinical characteristics of cytomegalovirus(CMV) infection after allogenic hematopoietic stem cell transplantation(allo-HSCT) and the effect of preemptive therapy. METHODS: A total of 134 patients who underwent allo-HSCT from March 2010 to March 2015 in the Department of Hematology of our hospital were enrolled in this study. The CMV infection rate, the median time of CMV infection occurence, and the risk factors for CMV infection after allo-HSCT, the response rate of preemptive treatment and the median time of CMV-DNA turning negative were analyzed...
August 2016: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/26201947/androgen-receptor-coactivators-in-regulation-of-growth-and-differentiation-in-prostate-cancer
#2
REVIEW
Zoran Culig
Androgen receptor (AR) is a key factor in regulation of growth and differentiation in normal and malignant prostate. Endocrine therapies for prostate cancer include inhibition of androgen production either by analogs of luteinizing hormone releasing hormone or abiraterone acetate and/or use of anti-androgens such as hydroxyflutamide, bicalutamide, and enzalutamide. Castration therapy-resistant cancer develops inevitably in patients who undergo treatment. AR coactivators are proteins which interact with one or more regions of the AR thus enhancing its function...
February 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/16329549/non-myeloablative-conditioning-for-hemopoietic-stem-cell-transplantation-does-it-work
#3
REVIEW
S-K Cheong, G-I Eow, C-F Leong
Allogeneic bone marrow or peripheral blood stem cell transplantation traditionally uses myeloablative regimen for conditioning to enable grafting of donor's stem cells. Animal experiments have shown that a milder non-myeloablative conditioning regimen does allow engraftment to occur. Nonmyeloablative conditioning regimens are low-intensity immunosuppressive treatment given to the recipient before infusion of donor's stem cells. It was reported to have decreased immediate procedural mortality, in particular those secondary to acute graft versus host reaction...
June 2002: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/221373/interferon-in-the-replication-of-herpes-simplex-virus-in-normal-and-pathological-nerve-cells
#4
N C de De La Peña, E Bal, L Puricelli, A Diaz, E S De Lustig
Previous results obtained in experimental and clinical trials have demonstrated that topical combined thrapy with human interferon (HI) and human colostral secretory immunoglobulin A (S-IgA) is effective against herpetic corneal infection. This therapy prevented encephalitis in rabbits but could not completely prevent recurrences either in rabbits or in patients. A number of in vitro studies were designed to elucidate the role of these factors in herpes simplex virus replication in the nervous system, with the following results: (1) HSV latency in trigeminal ganglia (TG) explanted from rabbits with experimental herpetic keratitis, topically treated with HI or HI/S-IgA: HSV was recovered in 30% TG after 15-19 days co-cultivation on RK-13 cells...
1978: IARC Scientific Publications
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