keyword
https://read.qxmd.com/read/38492842/aucubin-produces-anti-osteoporotic-effects-under-mechanical-stretch-stress-and-orthodontic-tooth-movement
#21
JOURNAL ARTICLE
Jiamiao Huang, Huan Jiang, Haoyu Wang, Qing Xue, Min Hu, Yutong Li
Aucubin (AU), an iridoid glycoside extracted from Eucommia ulmoides, exerts anti-osteoporotic effects by promoting osteogenesis, as reported in previous studies. Here, we investigated the effects of AU under mechanical stretch stress. MC3T3-E1 cells were treated with dexamethasone (DEX) in vitro and subjected to mechanical stretch stress to establish an osteoporotic orthodontic force cell model. AU treatment increased the mRNA and protein expressions of BMP2, OPN, RUNX2, COL-1 and other osteogenic differentiation factors in MC3T3-E1 cells...
March 14, 2024: Chemico-biological Interactions
https://read.qxmd.com/read/38492828/application-of-cuminaldehyde-and-ciprofloxacin-for-the-effective-control-of-biofilm-assembly-of-pseudomonas-aeruginosa-a-combinatorial-study
#22
JOURNAL ARTICLE
Moumita Malik, Sharmistha Das, Poulomi Chakraborty, Payel Paul, Ritwik Roy, Anirban Das Gupta, Sarita Sarkar, Sudipta Chatterjee, Alakesh Maity, Monikankana Dasgupta, Ranojit Kumar Sarker, Prosun Tribedi
Pseudomonas aeruginosa is widely associated with biofilm-mediated antibiotic resistant chronic and acute infections which constitute a persistent healthcare challenges. Addressing this threat requires exploration of novel therapeutic strategies involving the combination of natural compounds and conventional antibiotics. Hence, our study has focused on two compounds; cuminaldehyde and ciprofloxacin, which were strategically combined to target the biofilm challenge of P. aeruginosa. The minimum inhibitory concentration (MIC) of cuminaldehyde and ciprofloxacin was found to be 400 μg/mL and 0...
March 14, 2024: Microbial Pathogenesis
https://read.qxmd.com/read/38492808/sonic-hedgehog-signalling-pathway-contributes-in-age-related-disorders-and-alzheimer-s-disease
#23
REVIEW
Arun Parashar, Dhruv Jha, Vineet Mehta, Bonney Chauhan, Pappu Ghosh, Prashanta Kumar Deb, Mohit Jaiswal, Santosh Kumar Prajapati
Alzheimer's disease (AD) is caused by the aging process and manifested by cognitive deficits and progressive memory loss. During aging, several conditions, including hypertension, diabetes, and cholesterol, have been identified as potential causes of AD by affecting Sonic hedgehog (Shh) signalling. In addition to being essential for cell differentiation and proliferation, Shh signalling is involved in tissue repair and the prevention of neurodegeneration. Neurogenesis is dependent on Shh signalling; inhibition of this pathway results in neurodegeneration...
March 14, 2024: Ageing Research Reviews
https://read.qxmd.com/read/38492794/mechanism-interpretation-of-guhan-yangshengjing-for-protection-against-alzheimer-s-disease-by-network-pharmacology-and-molecular-docking
#24
JOURNAL ARTICLE
Suet Cheung, Yuan Zhong, Lei Wu, Xiaomeng Jia, Meng-Qi He, Yongjian Ai, Qisen Jiao, Qionglin Liang
ETHNOPHARMACOLOGICAL RELEVANCE: Guhan Yangshengjing (GHYSJ) is an effective prescription for delaying progression of Alzheimer's disease (AD) based on the ancient Chinese medical classics excavated from Mawangdui Han Tomb. Comprising a combination of eleven traditional Chinese herbs, the precise protective mechanism through which GHYSJ acts on AD progression remains unclear and has significant implications for the development of new drugs to treat AD. AIM OF THE STUDY: To investigate the mechanism of GHYSJ in the treatment of AD through network pharmacology and validate the results through in vitro experiments...
March 14, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38492783/an-engineered-tnfr1-selective-human-lymphotoxin-alpha-mutant-delivered-by-an-oncolytic-adenovirus-for-tumor-immunotherapy
#25
JOURNAL ARTICLE
Yan Cheng, Yu Liu, Dongge Xu, Dan Zhang, Yang Yang, Yuqing Miao, Susu He, Qing Xu, Erguang Li
Lymphotoxin α (LTα) is a soluble factor produced by activated lymphocytes which is cytotoxic to tumor cells. Although a promising candidate in cancer therapy, the application of recombinant LTα has been limited by its instability and toxicity by systemic administration. Secreted LTα interacts with several distinct receptors for its biological activities. Here, we report a TNFR1-selective human LTα mutant (LTα Q107E) with potent antitumor activity. Recombinant LTα Q107E with N-terminal 23 and 27 aa deletion (named LTα Q1 and Q2, respectively) showed selectivity to TNFR1 in both binding and NF-κB pathway activation assays...
March 14, 2024: Biochimica et Biophysica Acta. Molecular Basis of Disease
https://read.qxmd.com/read/38492752/exposure-to-pm-2-5-modulate-the-pro-inflammatory-and-interferon-responses-against-influenza-virus-infection-in-a-human-3d-bronchial-epithelium-model
#26
JOURNAL ARTICLE
Chloé Chivé, Lydie Martίn-Faivre, Alice Eon-Bertho, Christelle Alwardini, Jéril Degrouard, Alexandre Albinet, Gael Noyalet, Servanne Chevaillier, Franck Maisonneuve, Jean-Michel Sallenave, Stéphanie Devineau, Vincent Michoud, Ignacio Garcia-Verdugo, Armelle Baeza-Squiban
Epidemiological studies showed a positive association between exposure to PM2.5 and the severity of influenza virus infection. However, the mechanisms by which PM2.5 can disrupt antiviral defence are still unclear. From this perspective, the objective of this study was to evaluate the effects of PM2.5 on antiviral signalling in the respiratory epithelium using the bronchial Calu-3 cell line grown at the air-liquid interface. Pre-exposure to PM2.5 before infection with the influenza virus was investigated, as well as a co-exposure...
March 14, 2024: Environmental Pollution
https://read.qxmd.com/read/38492674/crosstalk-between-autophagy-and-inflammasomes-in-ricin-induced-inflammatory-injury
#27
JOURNAL ARTICLE
Shiji Zhang, Na Zhao, Suli Song, Yanchun Wang, Yan Wang, Chengbiao Sun, Mingxin Dong, Mengqi Huo, Na Xu, Wensen Liu, Guorui Li
Ricin (ricin toxin, RT) has the potential to cause damage to multiple organs and systems. Currently, there are no existing antidotes, vaccinations, or effective therapies to prevent or treat RT intoxication. Apart from halting protein synthesis, RT also induces oxidative stress, inflammation and autophagy. To explore the mechanisms of RT-induced inflammatory injury and specific targets of prevention and treatment for RT poisoning, we characterized the role of cross-talk between autophagy and NLRP3 inflammasome in RT-induced damage and elucidated the underlying mechanisms...
March 14, 2024: Toxicology and Applied Pharmacology
https://read.qxmd.com/read/38492673/interactions-between-skin-resident-dendritic-and-langerhans-cells-and-pain-sensing-neurons
#28
REVIEW
Natalie C Wilcox, Golnar Taheri, Katherine Halievski, Sebastien Talbot, Jaqueline R Silva, Nader Ghasemlou
Various immune cells in the skin contribute to its function as a first line of defence against infection/disease, while its dense innervation by pain-sensing sensory neurons protects the host from injury/damage signals. Dendritic cells (DCs) are a heterogeneous population of cells that link the innate immune response to the adaptive response by capturing, processing, and presenting antigens to promote T-cell differentiation and activation. DCs are abundant across peripheral tissues, including the skin, where they are found in the dermis and epidermis...
March 14, 2024: Journal of Allergy and Clinical Immunology
https://read.qxmd.com/read/38492628/unraveling-power-law-scaling-through-exponential-cell-division-dynamics
#29
JOURNAL ARTICLE
Jia-Xu Han, Zhuangdong Bai, Rui-Wu Wang
A primary objective of biology is the development of universal laws that define how organic form develops and how it evolves as a function of size, both ontogenetically and across evolutionary time. Scaling theory has been essential in reaching this goal by giving a complete perspective point, particularly in illuminating the fundamental biological features produced within scaling exponents defining families of equations. Nonetheless, the theoretical basis of the allometric equation within scaling theory are inadequately explained, particularly when it comes to establishing links between micro-level processes at the cellular level and macro-level phenomena...
March 14, 2024: Bio Systems
https://read.qxmd.com/read/38492609/identification-of-an-n-terminal-tag-580n-that-improves-the-biosynthesis-of-fluorescent-proteins-in-francisella-tularensis-and-other-gram-negative-bacteria
#30
JOURNAL ARTICLE
Kristen Haggerty, Stuart Cantlay, Emily Young, Mariah K Cashbaugh, Elio F Delatore Iii, Rori Schreiber, Hayden Hess, Daniel R Komlosi, Sarah Butler, Dalton Bolon, Theresa Evangelista, Takoda Hager, Claire Kelly, Katherine Phillips, Jada Voellinger, Robert M Q Shanks, Joseph Horzempa
Utilization of fluorescent proteins is widespread for the study of microbial pathogenesis and host-pathogen interactions. Here, we discovered that linkage of the 36 N-terminal amino acids of FTL_0580 (a hypothetical protein of Francisella tularensis) to fluorescent proteins increases the fluorescence emission of bacteria that express these recombinant fusions. This N-terminal peptide will be referred to as 580N. Western blotting revealed that the linkage of 580N to Emerald Green Fluorescent Protein (EmGFP) in F...
March 14, 2024: Molecular and Cellular Probes
https://read.qxmd.com/read/38492569/an-engineering-strategy-to-target-activated-egfr-with-car-t%C3%A2-cells
#31
JOURNAL ARTICLE
Markus Dobersberger, Delia Sumesgutner, Charlotte U Zajc, Benjamin Salzer, Elisabeth Laurent, Dominik Emminger, Elise Sylvander, Elisabeth Lehner, Magdalena Teufl, Jacqueline Seigner, Madhusudhan Reddy Bobbili, Renate Kunert, Manfred Lehner, Michael W Traxlmayr
Chimeric antigen receptor (CAR) T cells have shown remarkable response rates in hematological malignancies. In contrast, CAR T cell treatment of solid tumors is associated with several challenges, in particular the expression of most tumor-associated antigens at lower levels in vital organs, resulting in on-target/off-tumor toxicities. Thus, innovative approaches to improve the tumor specificity of CAR T cells are urgently needed. Based on the observation that many human solid tumors activate epidermal growth factor receptor (EGFR) on their surface through secretion of EGFR ligands, we developed an engineering strategy for CAR-binding domains specifically directed against the ligand-activated conformation of EGFR...
March 12, 2024: Cell Rep Methods
https://read.qxmd.com/read/38492541/inhibition-of-cancer-cells-by-quinoline-based-compounds-a-review-with-mechanistic-insights
#32
REVIEW
Anjali Saxena, Suman Majee, Devalina Ray, Biswajit Saha
This article includes a thorough examination of the inhibitory potential of quinoline-based drugs on cancer cells, as well as an explanation of their modes of action. Quinoline derivatives, due to their various chemical structures and biological activity, have emerged as interesting candidates in the search for new anticancer drugs. The review paper delves into the numerous effects of quinoline-based chemicals in cancer progression, including apoptosis induction, cell cycle modification, and interference with tumor-growth signaling pathways...
March 12, 2024: Bioorganic & Medicinal Chemistry
https://read.qxmd.com/read/38492520/inhibition-of-pedv-viral-entry-upon-blocking-n-glycan-elaboration
#33
JOURNAL ARTICLE
Yong Zhao, Tao Tang, Wenchang Zhao, Weiguang Fu, Tao Li
Porcine Epidemic Diarrhea Virus (PEDV) poses a significant threat to the global swine industry, demanding a thorough understanding of its cellular invasion mechanism for effective interventions. This study meticulously investigates the impact of O- and N-linked glycans on PEDV proteins and host cell interaction, shedding light on their influence on the virus's invasion process. Utilizing CRISPR-Cas9 technology to inhibit cell surface O- and N-linked glycan synthesis demonstrated no discernible impact on virus infection...
March 12, 2024: Virology
https://read.qxmd.com/read/38492486/-deciphering-the-enigmatic-role-of-gamma-aminobutyric-acid-gaba-in-plants-synthesis-transport-regulation-signaling-and-biological-roles-in-interaction-with-growth-regulators-and-abiotic-stresses
#34
REVIEW
Saif Ahmad, Qazi Fariduddin
Gamma-aminobutyric acid (GABA) is an amino acid with a four-carbon structure, widely distributed in various organisms. It exists as a zwitterion, possessing both positive and negative charges, enabling it to interact with other molecules and participate in numerous physiological processes. GABA is widely distributed in various plant cell compartments such as cytoplasm mitochondria, vacuoles, peroxisomes, and plastids. GABA is primarily synthesized from glutamate using glutamate decarboxylase and participates in the GABA shunt within mitochondria, regulating carbon and nitrogen metabolism in plants The transport of GABA is regulated by several intracellular and intercellular transporters such as aluminium-activated malate transporters (ALMTs), GABA transporters (GATs), bidirectional amino acid transporters (BATs), and cationic amino acid transporters (CATs)...
March 8, 2024: Plant Physiology and Biochemistry: PPB
https://read.qxmd.com/read/38492440/updating-functional-brain-units-insights-far-beyond-luria
#35
REVIEW
Jordi Peña-Casanova, Gonzalo Sánchez-Benavides, Jorge Sigg-Alonso
This paper reviews Luria's model of the three functional units of the brain. To meet this objective, several issues were reviewed: the theory of functional systems and the contributions of phylogenesis and embryogenesis to the brain's functional organization. This review revealed several facts. In the first place, the relationship/integration of basic homeostatic needs with complex forms of behavior. Secondly, the multi-scale hierarchical and distributed organization of the brain and interactions between cells and systems...
February 29, 2024: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://read.qxmd.com/read/38492437/novel-nitric-oxide-donors-are-coronary-vasodilators-that-also-bind-to-the-papain-like-protease-of-sars-cov-2
#36
JOURNAL ARTICLE
John F Schmedtje, Fred Ciske, Kendall M Muzzarelli, Zahra Assar
Several investigational nitric oxide donors were originally created to correct vascular endothelial dysfunction in cardiovascular diseases. These 48 compounds contain an urea-like moiety attached to the well-known NO donors isosorbide 2- and 5-mononitrate. CR-0305 and CR-0202 were synthesized and found to be nontoxic in the cell lines HMEC-1, A549/hACE2 and VeroE6. CR-0305 induced vasodilation in human coronary arteries ex vivo. Since NO can also have antiviral properties, a study of drug-protein interactions with SARS-CoV-2 was undertaken using in silico modeling...
March 15, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38492429/mitochondrial-transcription-factor-a-tfam-has-5-deoxyribose-phosphate-lyase-activity-in-vitro
#37
JOURNAL ARTICLE
Wenxin Zhao, Adil S Hussen, Bret D Freudenthal, Zucai Suo, Linlin Zhao
Mitochondrial DNA (mtDNA) plays a key role in mitochondrial and cellular functions. mtDNA is maintained by active DNA turnover and base excision repair (BER). In BER, one of the toxic repair intermediates is 5'-deoxyribose phosphate (5'dRp). Human mitochondrial DNA polymerase γ has weak dRp lyase activities, and another known dRp lyase in the nucleus, human DNA polymerase β, can also localize to mitochondria in certain cell and tissue types. Nonetheless, whether additional proteins have the ability to remove 5'dRp in mitochondria remains unknown...
March 8, 2024: DNA Repair
https://read.qxmd.com/read/38492368/mitigating-phospholipid-peroxidation-of-macrophages-in-stress-induced-tumor-microenvironment-by-natural-alox15-pebp1-complex-inhibitors
#38
JOURNAL ARTICLE
Xiang Luo, Dong-Dong Li, Zi-Chun Li, Zi-Xuan Li, De-Hua Zou, Feng Huang, Guan Wang, Rong Wang, Yun-Feng Cao, Wan-Yang Sun, Hiroshi Kurihara, Lei Liang, Yi-Fang Li, Wen Jin, Yan-Ping Wu, Rong-Rong He
BACKGROUND: The intricate interactions between chronic psychological stress and susceptibility to breast cancer have been recognized, yet the underlying mechanisms remain unexplored. Danzhi Xiaoyao Powder (DZXY), a traditional Chinese medicine (TCM) formula, has found clinical utility in the treatment of breast cancer. Macrophages, as the predominant immune cell population within the tumor microenvironment (TME), play a pivotal role in orchestrating tumor immunosurveillance. Emerging evidence suggests that lipid oxidation accumulation in TME macrophages, plays a critical role in breast cancer development and progression...
February 22, 2024: Phytomedicine
https://read.qxmd.com/read/38492348/prolactin-promotes-the-recruitment-of-main-olfactory-bulb-cells-and-enhances-the-behavioral-exploration-toward-a-socio-sexual-stimulus-in-female-mice
#39
JOURNAL ARTICLE
Viridiana Cerbantez-Bueno, Verónica Viñuela-Berni, Daniel Eduardo Muñoz-Mayorga, Teresa Morales, Rebeca Corona
Olfactory communication is triggered by pheromones that profoundly influence neuroendocrine responses to drive social interactions. Two principal olfactory systems process pheromones: the main and the vomeronasal or accessory system. Prolactin receptors are expressed in both systems suggesting a participation in the processing of olfactory information. We previously reported that prolactin participates in the sexual and olfactory bulb maturation of females. Therefore, we explored the expression of prolactin receptors within the olfactory bulb during sexual maturation and the direct responses of prolactin upon pheromonal exposure...
March 15, 2024: Hormones and Behavior
https://read.qxmd.com/read/38492336/interleukin-1%C3%AE-polarization-in-m1-macrophage-mediates-myocardial-fibrosis-in-diabetes
#40
JOURNAL ARTICLE
Wenli Guo, Chen Yang, Jiawei Zou, Tingting Yu, Mingde Li, Ruilin He, Keyang Chen, Rafaela C R Hell, Eric R Gross, Xin Zou, Yao Lu
BACKGROUND: Diabetes is a global health problem whose common complication is diabetic cardiomyopathy, characterized by chronic inflammation of the heart muscle. Macrophages are the main white blood cells found in the resting heart. Therefore, we investigated the underling mechanism of macrophage on myocardial fibrosis in diabetes. METHODS: Here, echocardiography was utilized to evaluate cardiac function, and the degree of myocardial fibrosis was assessed using Masson's trichrome staining, followed by single-cell RNA sequencing (scRNA-seq) to analyze the phenotype, function, developmental trajectory, and interactions between immune cells, endothelial cells (ECs), and fibroblasts (FBs) in the hearts of db/db mice at different stages of diabetes...
March 15, 2024: International Immunopharmacology
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