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https://www.readbyqxmd.com/read/29232700/sygl-1-and-lst-1-link-niche-signaling-to-puf-rna-repression-for-stem-cell-maintenance-in-caenorhabditis-elegans
#1
Heaji Shin, Kimberly A Haupt, Aaron M Kershner, Peggy Kroll-Conner, Marvin Wickens, Judith Kimble
Central questions in regenerative biology include how stem cells are maintained and how they transition from self-renewal to differentiation. Germline stem cells (GSCs) in Caenorhabditis elegans provide a tractable in vivo model to address these questions. In this system, Notch signaling and PUF RNA binding proteins, FBF-1 and FBF-2 (collectively FBF), maintain a pool of GSCs in a naïve state. An open question has been how Notch signaling modulates FBF activity to promote stem cell self-renewal. Here we report that two Notch targets, SYGL-1 and LST-1, link niche signaling to FBF...
December 12, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29232637/copper-ii-complexes-based-on-tripodal-pyrazolyl-amines-synthesis-structure-magnetic-properties-and-anticancer-activity
#2
Salah S Massoud, Febee R Louka, Gerard T Ducharme, Roland C Fischer, Franz A Mautner, Ján Vančo, Radovan Herchel, Zdeněk Dvořák, Zdeněk Trávníček
The Cu(II) complexes [Cu(bpdmpz)Cl]ClO4 (1), [Cu(bdmpzp)Cl]ClO4 (2-ClO4), [Cu(bdmpzp)Cl]PF6 (2-PF6) and [Cu(tdmpza)Cl]ClO4 (3), bpdmpzp=[bis[((2-pyridylmethyl)-di(3,5-dimethyl-1H-pyrazolyl)methyl)]amine, bdmpzp=[bis((di(3,5-dimethyl-1H-pyrazolyl)methyl)-(2-pyridylmethyl)]amine and tdmpza=tris[di(3,5-dimethyl-1H-pyrazolyl)-methyl)]amine were synthesized and characterized by elemental analysis, magnetic and conductivity measurements, electrospray-ionization mass spectrometry, infrared and electronic spectroscopy, and X-ray crystallography...
December 5, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29232611/ocean-acidification-increases-the-toxic-effects-of-tio2-nanoparticles-on-the-marine-microalga-chlorella-vulgaris
#3
Bin Xia, Qi Sui, Xuemei Sun, Qian Han, Bijuan Chen, Lin Zhu, Keming Qu
Concerns about the environmental effects of engineered nanoparticles (NPs) on marine ecosystems are increasing. Meanwhile, ocean acidification (OA) has become a global environmental problem. However, the combined effects of NPs and OA on marine organisms are still not well understood. In this study, we investigated the effects of OA (pH values of 7.77 and 7.47) on the bioavailability and toxicity of TiO2 NPs to the marine microalga Chlorella vulgaris. The results showed that OA enhanced the growth inhibition of algal cells caused by TiO2 NPs...
December 7, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29232585/synthesis-of-new-triterpenic-monomers-and-dimers-as-potential-antiproliferative-agents-and-their-molecular-docking-studies
#4
Aasim Saeed, Hidayat Hussain, Umair Shamraiz, Najeeb Ur Rehman, Husain Yar Khan, Amin Badshah, Lucie Heller, René Csuk, Majid Ali, Ajmal Khan, Ahmed Al-Harrasi
In the current investigation, new monomers of myrrhanone B and lupeolic acid were prepared via reaction of triterpenic acids with linkers in the presence of K2CO3. In addition, new bis-myrrhanone B homodimers, myrrhanone B-myrrhanol B heterodimers, and bis-myrrhanone β-boswellic acids heterodimer were prepared. Evaluation of these compounds on the proliferation of four different human cancer cell lines, viz., FaDu (pharynx carcinoma), A2780 (ovarian carcinoma), HT29 (colon adenocarcinoma) and A375 (malignant melanoma) has been performed...
December 9, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29232552/therapeutic-antibody-targeting-tumor-and-osteoblastic-niche-derived-jagged1-sensitizes-bone-metastasis-to-chemotherapy
#5
Hanqiu Zheng, Yangjin Bae, Sabine Kasimir-Bauer, Rebecca Tang, Jin Chen, Guangwen Ren, Min Yuan, Mark Esposito, Wenyang Li, Yong Wei, Minhong Shen, Lanjing Zhang, Nikolai Tupitsyn, Klaus Pantel, Chadwick King, Jan Sun, Jodi Moriguchi, Helen Toni Jun, Angela Coxon, Brendan Lee, Yibin Kang
Bone metastasis is a major health threat to breast cancer patients. Tumor-derived Jagged1 represents a central node in mediating tumor-stromal interactions that promote osteolytic bone metastasis. Here, we report the development of a highly effective fully human monoclonal antibody against Jagged1 (clone 15D11). In addition to its inhibitory effect on bone metastasis of Jagged1-expressing tumor cells, 15D11 dramatically sensitizes bone metastasis to chemotherapy, which induces Jagged1 expression in osteoblasts to provide a survival niche for cancer cells...
December 11, 2017: Cancer Cell
https://www.readbyqxmd.com/read/29232484/juvenile-social-experience-and-differential-age-related-changes-in-the-dendritic-morphologies-of-subareas-of-the-prefrontal-cortex-in-rats
#6
B T Himmler, R Mychasiuk, A Nakahashi, S M Himmler, S M Pellis, B Kolb
Juvenile social interactions have been shown to influence the dendritic complexity of neurons in the prefrontal cortex. In particular, social play induces pruning of the cells in the medial prefrontal cortex (mPFC), whereas interacting with multiple partners, whether those interactions involve play or not, increases the complexity of cells in the orbital frontal cortex (OFC). Previous studies suggest that these changes differ in their stability during adulthood. In the present study, rats were reared in groups of either four (quads) or two (pairs) and the brains of the rats from each rearing condition were then harvested at 60 days (i...
December 12, 2017: Synapse
https://www.readbyqxmd.com/read/29232391/studies-of-the-structure-antioxidant-activity-relationships-and-antioxidant-activity-mechanism-of-iridoid-valepotriates-and-their-degradation-products
#7
Feifei Wang, Yumei Zhang, Shouhai Wu, Yi He, Zhong Dai, Shuangcheng Ma, Bin Liu
Oxidative stress has been associated with diverse diseases, including obesity, cancer and neurodegeneration. In fact, Valeriana jatamansi Jones (valerian) and its extracts possess strong antioxidant activities that extend their application in clinical practice to the treatment of these illnesses, even though the underlying mechanisms are not well understood. Iridoid valepotriate, a characteristic iridoid ester in valerian with poor chemical stability, possesses considerable antioxidant components. The original compounds and their degradation products have been found to exhibit strong antioxidant activities...
2017: PloS One
https://www.readbyqxmd.com/read/29232376/che1-aatf-interacts-with-subunits-of-the-histone-acetyltransferase-core-module-of-saga-complexes
#8
Gizem Caliskan, Ikbal C Baris, Ferhan Ayaydin, Melanie J Dobson, Muge Senarisoy, Imre M Boros, Zeki Topcu, Sevil Zencir
General Control Non-derepressible 5 (GCN5) and Alteration/Deficiency in Activation 2 and 3 proteins (ADA2 and ADA3, respectively) are subunits of the Histone AcetylTransferase (HAT) module of SAGA- and ATAC-type co-activators. We previously reported four new interacting partners of human ADA3 identified by screening a human fetal brain cDNA library using yeast two hybrid technology. One of these partners was Apoptosis-Antagonizing Transcription Factor (AATF), also known as Che-1, an RNA polymerase II-binding protein with a number of roles in different cellular processes including regulation of transcription, cell proliferation, cell cycle control, DNA damage responses and apoptosis...
2017: PloS One
https://www.readbyqxmd.com/read/29232318/significant-effect-of-acupressure-in-elevating-blood-stem-cell-factor-during-chemotherapy-in-patients-with-gynecologic-cancer
#9
Ya-Wen Shih, Shun-Fa Yang, Ming-Hsien Chien, Ching-Wen Chang, Vincent H S Chang, Hsiu-Ting Tsai
BACKGROUND: Chemotherapy is used mainly to treat and control the progression of gynecological cancer. Bone marrow suppression, one of the adverse side effects of chemotherapy, may decrease immune function, increasing the risk of serious, fatal infections. PURPOSE: The aims of this study were to evaluate the effectiveness of noninvasive acupressure in preventing and diminishing chemotherapy-induced myelosuppression in patients with gynecologic cancer and to determine whether this effect is associated with the regulation of the expressions of granulocyte-macrophage colony-stimulating factor and stem cell factor (SCF)...
December 9, 2017: Journal of Nursing Research: JNR
https://www.readbyqxmd.com/read/29232144/interactions-between-surface-immobilized-antimicrobial-peptides-and-model-bacterial-cell-membranes
#10
Xiaofeng Han, Jingguo Zheng, Fengming Lin, Kenichi Kuroda, Zhan Chen
Sum frequency generation vibrational spectroscopy (SFG) was used to study surface immobilization effects on the interactions between antimicrobial peptide (AMP) cecropin P1 (CP1) and model cell membranes. While free CP1 in solution interacted with a model cell membrane composed of a phosphatidylglycerole (PG) bilayer, electrostatic interaction led to the attachment of the CP1 molecules onto the PG surface, and the hydrophobic domain in the lipid bilayer enabled the peptides to insert into the bilayer and form α-helices from random coil structures...
December 12, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29232139/distinguishing-surface-versus-bulk-hydroxyl-groups-of-cellulose-nanocrystals-using-vibrational-sum-frequency-generation-spectroscopy
#11
Mohamadamin Makarem, Christopher M Lee, Daisuke Sawada, Hugh M O'Neill, Seong H Kim
In plant cell walls and cellulose-containing composites, nanocrystalline cellulose interacts with water molecules or matrix polymers through hydrogen bonding of the hydroxyl groups at the cellulose surface. These interactions play key roles in cellulose assembly in plant cell walls and mechanical properties of cellulose-composites; however, they could not be studied properly due to the spectroscopic difficulty of selectively detecting the surface hydroxyl groups of nanocrystalline domains. This study employed the sum frequency scattering principle to distinguish the hydroxyl groups inside the crystalline nanodomain of cellulose and those exposed at the surface of crystalline domains...
December 12, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29232104/the-effects-of-biological-fluids-on-colloidal-stability-and-sirna-delivery-of-a-ph-responsive-micellar-nanoparticle-delivery-system
#12
Dominic W Malcolm, Jomy J Varghese, Janet E Sorrells, Catherine E Ovitt, Danielle S W Benoit
Nanoparticles (NP) interact with complex protein milieus in biological fluids, and these interactions have profound effects on NP physicochemical properties and function. Surprisingly, most studies neglect the impact of these interactions, especially with respect to NP-mediated siRNA delivery. Here, the effects of serum on colloidal stability and siRNA delivery of a pH-responsive micellar NP delivery system were characterized. Results show cationic NP-siRNA complexes aggregate in  2% serum in buffer, but are stable in serum-free media...
December 12, 2017: ACS Nano
https://www.readbyqxmd.com/read/29232098/amyloid-%C3%AE-1-40-toxicity-depends-on-the-molecular-contact-between-phenylalanine-19-and-leucine-34
#13
Alexander Korn, Steffane McLennan, Juliane Adler, Martin Krueger, Dayana Surendran, Sudipta Maiti, Daniel Huster
The formation of the hydrophobic contact between phenylalanine 19 (F19) and leucine 34 (L34) of amyloid β (1-40) (Aβ(1-40)) is known to be an important step in the fibrillation of Aβ(1-40) peptides. Mutations of this putatively early molecular contact were shown to strongly influence the toxicity of Aβ(1-40) (Das et al., ACS Chem. Neurosci. 6 (2015) 1290-1295). Any mutation of residue F19 completely abolished the toxicity of Aβ(1-40), suggesting that a proper F19 - L34 contact is crucial also for the formation of transient oligomers...
December 12, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29232012/the-genetics-underlying-natural-variation-of-plant-plant-interactions-a-beloved-but-forgotten-member-of-the-family-of-biotic-interactions
#14
Harihar Jaishree Subrahmaniam, Cyril Libourel, Etienne-Pascal Journet, Jean-Benoît Morel, Stéphane Muños, Andreas Niebel, Sylvain Raffaele, Fabrice Roux
Despite the importance of plant-plant interactions on crop yield and plant community dynamics, our understanding of the genetic and molecular bases underlying natural variation of plant-plant interactions is largely limited in comparison to other types of biotic interactions. By listing 63 QTL mapping and global gene expression studies based on plants directly challenged by other plants, we explored whether the genetic architecture and the function of the candidate genes underlying natural plant-plant interactions depend on the type of interactions between two plants (competition vs commensalism vs reciprocal helping vs asymmetry)...
December 12, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29231862/conserved-binding-regions-provide-the-clue-for-peptide-based-vaccine-development-a-chemical-perspective
#15
REVIEW
Hernando Curtidor, César Reyes, Adriana Bermúdez, Magnolia Vanegas, Yahson Varela, Manuel E Patarroyo
Synthetic peptides have become invaluable biomedical research and medicinal chemistry tools for studying functional roles, i.e., binding or proteolytic activity, naturally-occurring regions' immunogenicity in proteins and developing therapeutic agents and vaccines. Synthetic peptides can mimic protein sites; their structure and function can be easily modulated by specific amino acid replacement. They have major advantages, i.e., they are cheap, easily-produced and chemically stable, lack infectious and secondary adverse reactions and can induce immune responses via T- and B-cell epitopes...
December 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29231851/enhanced-methods-to-estimate-the-efficiency-of-magnetic-nanoparticles-in-imaging
#16
Ann M Hirt, Monika Kumari, David Heinke, Alexander Kraupner
Magnetic resonance imaging (MRI) and magnetic particle imaging (MPI) are powerful methods in the early diagnosis of diseases. Both imaging techniques utilize magnetic nanoparticles that have high magnetic susceptibility, strong saturation magnetization, and no coercivity. FeraSpinTM R and its fractionated products have been studied for their imaging performances; however, a detailed magnetic characterization in their immobilized state is still lacking. This is particularly important for applications in MPI that require fixation of magnetic nanoparticles with the target cells or tissues...
December 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29231815/endothelial-cells-express-nkg2d-ligands-and-desensitize-anti-tumor-nk-responses
#17
Thornton W Thompson, Alexander Byungsuk Kim, Po-Yi Jonathan Li, Jiaxi Wang, Benjamin T Jackson, Kristen Ting Hui Huang, Lily Zhang, David H Raulet
Natural Killer (NK) cells confer protection from tumors and infections by releasing cytotoxic granules and pro-inflammatory cytokines upon recognition of diseased cells. The responsiveness of NK cells to acute stimulation is dynamically tuned by steady-state receptor-ligand interactions of an NK cell with its cellular environment. Here we demonstrate that in healthy WT mice the NK activating receptor NKG2D is engaged in vivo by one of its ligands, RAE-1ε, which is expressed constitutively by lymph node endothelial cells and highly induced on tumor-associated endothelium...
December 12, 2017: ELife
https://www.readbyqxmd.com/read/29231798/n-cadherin-knockdown-leads-to-disruption-of-trophoblastic-and-endothelial-cell-interaction-in-a-3d-cell-culture-model-new-insights-in-trophoblast-invasion-failure
#18
A Multhaup, B Huppertz, C Göhner, M Böhringer, M Mai, U Markert, E Schleußner, T Groten
INTRODUCTION: Trophoblast homing to maternal spiral arteries is mandatory for successful placentation. Cell-cell adhesion molecules regulate this process and adhesion molecule expression is altered in impaired placentation. We hypothesize that, similar to immune cell recruitment, trophoblast cell adherence and rolling are primarily mediated by adhesion molecules like, cadherins, immunoglobulins, selectins and their partnering ligands. Here, the interdependence of adhesion molecule expression in trophoblastic cell lines of diverse origin was investigated in relation to their interaction with endothelial cell networks on Matrigel® co-cultures and the effect of specific adhesion molecule knockdown analyzed...
December 12, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/29231737/stability-of-polyethylene-glycol-and-zwitterionic-surface-modifications-in-pdms-microfluidic-flow-chambers
#19
Thomas James Plegue, Kyle M Kovach, Alex J Thompson, Joseph A Potkay
Blood-material interactions are crucial to the lifetime, safety, and overall success of a blood contacting devices. Hydrophilic polymer coatings have been employed to improve device lifetime by shielding blood contacting materials from the natural foreign body response, primarily the intrinsic pathway of the coagulation cascade. These coatings have the ability to repel proteins, cells, bacteria, and other micro-organisms. Coatings are desired to have long-term stability, so that the nonthrombogenic and nonfouling effects gained are long lasting...
December 12, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29231707/sulfonate-groups-and-saccharides-as-essential-structural-elements-in-heparin-mimicking-polymers-used-as-surface-modifiers-optimization-of-relative-contents-for-anti-thrombogenic-properties
#20
Xianshuang Chen, Hao Gu, Zhonglin Lyu, Xiaoli Liu, Lei Wang, Hong Chen, John Law Brash
Blood compatibility is a long sought-after goal in biomaterials research, but remains an elusive one, and in spite of extensive work in this area, there is still no definitive information on the relationship between material properties and blood responses such as coagulation and thrombus formation. Materials modified with heparin-mimicking polymers (HMP) have shown promise, and indeed may be seen as comparable to materials modified with heparin itself. In this work, heparin was conceptualized as consisting of two major structural elements: saccharide-containing and sulfonate-containing units, and polymers based on this concept were developed...
December 12, 2017: ACS Applied Materials & Interfaces
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