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https://www.readbyqxmd.com/read/27757797/light-chains-removal-by-extracorporeal-techniques-in-acute-kidney-injury-due-to-multiple-myeloma-a-position-statement-of-the-onconephrology-work-group-of-the-italian-society-of-nephrology
#1
P Fabbrini, K Finkel, M Gallieni, G Capasso, M Cavo, A Santoro, S Pasquali
Acute kidney injury (AKI) is a frequent complication of multiple myeloma and is associated with increased short-term mortality. Additionally, even a single episode of AKI can eventually lead to end-stage renal disease (ESRD), significantly reducing quality of life and long-term survival. In the setting of multiple myeloma, severe AKI (requiring dialysis) is typically secondary to cast nephropathy (CN). Renal injury in CN is due to intratubular obstruction from precipitation of monoclonal serum free light chains (sFLC) as well as direct tubular toxicity of sFLC via stimulation of nuclear factor (NF)κB inflammatory pathways...
December 2016: Journal of Nephrology
https://www.readbyqxmd.com/read/27514761/onconephrology-what-should-the-internist-know-about-targeted-therapy-in-solid-tumors
#2
Elie El Rassy, Fadi El Karak, Jamale Rizkallah, Dania Chelala
Advances in medical oncology has led cancer patients to live longer. Moreover, the field of molecular oncology is rapidly evolving, new therapies emerge, and drugs are approved quickly. This has led nephrologists to encounter new and partially unrecognized treatments of the targeted therapy agents with kidney adverse effects. These agents fall mainly into 2 categories affecting the vascular endothelial growth factor and endothelial growth factor pathways. This review covers the incidence of kidney disease induced by these agents, pathophysiologic mechanisms, and clinical presentation, and is the first to recommend an adequate management for each pathophysiology...
July 2016: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/26413292/onconephrology-abstracts-and-publication-trends-time-to-collaborate
#3
Jyotsana Thakkar, Rimda Wanchoo, Kenar D Jhaveri
Onconephrology is an emerging subspecialty of nephrology. The American Society of Nephrology(ASN) created a forum dedicated to the field of onconephrology in 2011 to improve collaborative care for cancer patients with kidney disease. In this article, we review the ASN Kidney Week abstracts that were related to onconephrology. There has been an increase in the number of onconephrology-related abstracts at ASN over last 3 years. But only one-fifth of abstracts that were onconephrology related in ASN were published in peer review journals...
October 2015: Clinical Kidney Journal
https://www.readbyqxmd.com/read/25734768/renal-effects-of-targeted-anticancer-therapies
#4
REVIEW
Camillo Porta, Laura Cosmai, Maurizio Gallieni, Paolo Pedrazzoli, Fabio Malberti
The use of novel targeted anticancer agents has led to overall improvement in the prognosis of many patients affected by various malignancies, but has also been associated with an increased risk of poorly characterized toxic effects to different organs, including the kidneys. The high prevalence of kidney impairment in the general population complicates the issue further. Nephrologists most frequently work with patients with cancer when they are asked to investigate kidney function to assess the need for dose adjustments in anticancer therapy...
June 2015: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/25480873/inhibition-of-the-vegf-signalling-pathway-and-glomerular-disorders
#5
REVIEW
Mario Ollero, Djillali Sahali
Anti-cancer therapeutic approaches targeting the vascular endothelial growth factor (VEGF) ligand (anti-VEGF) or inhibiting its receptors (RTKI) have recently been developed. In spite of the promising results achieved, a serious drawback and dose-limiting side effect is the development, among others, of renal complications. This encompasses two glomerular pathological entities, namely minimal change/focal segmental glomerulosclerosis and thrombotic micro-angiopathy, involving two distinct cell types, podocytes and endothelial cells, respectively...
September 2015: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/24786870/onconephrology-the-need-and-the-emergence-of-a-subspecialty-in-nephrology
#6
Ala A Abudayyeh, Amit Lahoti, Abdulla K Salahudeen
No abstract text is available yet for this article.
May 2014: Kidney International
https://www.readbyqxmd.com/read/23138480/onconephrology-the-latest-frontier-in-the-war-against-kidney-disease
#7
Abdulla K Salahudeen, Joseph V Bonventre
Renal diseases in patients with cancer have many unique features, and often these diseases require specialized approaches. Newer cancer therapy has increased cancer cure rate and survival time, but such benefit is not fully realized, partly because of therapy-associated toxicities. Fluid and electrolyte abnormalities are very common in patients with cancer, as are acute and chronic kidney injury. With the evolving complexities of newer cancer therapies, a comprehensive team approach is becoming necessary. It is essential for nephrologists to be informed and involved in cancer care...
January 2013: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/22879433/onco-nephrology-aki-in-the-cancer-patient
#8
REVIEW
Albert Q Lam, Benjamin D Humphreys
AKI is common in patients with cancer, and it causes interruptions in therapy and increased hospital length of stay, cost, and mortality. Although cancer patients are susceptible to all of the usual causes of AKI in patients without cancer, there are a number of AKI syndromes that occur more frequently or are unique to this patient population. AKI also confers substantially increased risk of short-term death, and the ability to reverse AKI portends a better outcome in some cancers, such as multiple myeloma...
October 2012: Clinical Journal of the American Society of Nephrology: CJASN
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