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L B Xu, N Chi, W Shi
This study examined the mechanism of action of amiloride, a urokinase-type plasminogen activator receptor inhibitor, in lowering proteinuria. Podocytes were resuscitated to allow for their proliferation and were observed for morphological changes. In the in vitro experiment, control, lipopolysaccharide, and lipopolysaccharide + amiloride groups were established. The expression of urokinase-type plasminogen activator receptor (uPAR) in podocytes was detected with a flow cytometer and cell motility was detected with the transwell migration assay...
2015: Genetics and Molecular Research: GMR
Yu Han, Jin-Shan Lu, Yong Xu, Lei Zhang, Bao-Fa Hong
OBJECTIVES: Rutin, a polyphenolic flavonoid, was reported to have beneficial effect on drug induced nephropathy. The present study aimed to introduce 5/6 nephrectomized rat model to further evaluate its renal protective effect. METHODS: Adult Wistar rats were induced to develop chronic renal failure through 5/6 nephrectomy (5/6 Nx). After that, animals were treated orally with saline, rutin at 15 and 45 mg/kg, and losartan (10 mg/kg) daily for 20 weeks; sham-operated animals were also involved as control...
2015: International Journal of Clinical and Experimental Pathology
Momo Maruoka, Shinichiro Tsunoda, Tetsuya Furukawa, Okuto Honda, Takahiro Yoshikawa, Kazuyuki Fujita, Yuki Sekiguchi, Chieri Satou, Atsushi Saitou, Aki Nishioka, Masahiro Sekiguchi, Naoto Azuma, Masayasu Kitano, Kiyoshi Matsui, Hiroaki Shibahara, Hajime Sano
SUMMARY: A 39-year-old woman was diagnosed with Systemic lupus erthymatosus (SLE) in 1993, and initially received 30 mg of prednisolone (PSL) daily as treatment. In 2012, the patient was diagnosed with pregnancy-induced hypertension (PIH) complecated with proteinurea, hypertension and pretibial edema at 24 weeks of gestation. At onset, protein urea was 1.6 g/day and she was given bed rest in the hospital with a protein-restricted and low salt diet, which led to a decrease in protein urea to approximately 1 g/day...
2015: Nihon Rinshō Men'eki Gakkai Kaishi, Japanese Journal of Clinical Immunology
Tami Annable, Tamar Tomassian, Siddhartha Jain, Martha Leibbrandt, Michael P Cooke, Jonathan A Deane
Subunit vaccines are typically poorly immunogenic when administered alone, and require adjuvants for robust responses. Triggering TLRs to boost antigen-specific adaptive immunity is an attractive approach to increase the potency and quality of vaccines. However, recent reports suggest that alterations in TLR expression are associated with the pathogenesis of inflammatory and autoimmune diseases. To compare genetic studies with adjuvant studies, we examined whether stimulation through a TLR agonist induces or increases the autoimmune phenotype of healthy or autoimmune mice...
February 2015: Autoimmunity
Zahra Rezaieyazdi, Tahmine Tavakoli, Mohammad Khajehdaluee, Shahram Honarmand
Mycophenolate mofetil (MMF) has long been used to manage lupus nephritis. Despite research on its long-term efficacy, it is still warranted to conduct further investigation regarding its indications, safety and outcome. This study was intended to evaluate our proposed protocol in maintenance therapy with MMF. Twenty-four lupus nephritis patients were registered prior to their receiving 3-6 month induction therapy with monthly iv pulses of cyclophosphamide (CYC), followed by 24 month maintenance therapy using MMF and steroid...
2014: SpringerPlus
Rohit Borker
OBJECTIVE: To estimate adverse event (AE) costs in patients receiving targeted therapies for the first line treatment of metastatic renal cell carcinoma (mRCC). METHODS: Retrospective study based on healthcare claims data for patients with mRCC, aged ≥18 years, receiving first-line treatment with targeted therapies. AEs of interest comprised of abdominal pain, back pain, diarrhea, dyspnea, extremity pain, fatigue/asthenia, hand-foot syndrome, hypertension, lymphopenia, nausea/vomiting, neutropenia, proteinuria, and thrombocytopenia...
November 2014: Journal of Medical Economics
Z Bouzari, M Javadiankutenai, A Darzi, S Barat
OBJECTIVE: Preeclampsia is defined by the new onset of elevated blood pressure and protienuria after 20 weeks of gestation. Protienuria is one of the essential criteria for the clinical definition of preeclampsia. The authors investigated the predictive value of proteinuria in the outcome of pregnancies with preeclampsia. MATERIALS AND METHODS: In this retrospective cohort study, they entered all pregnant women who were admitted with diagnosis of preeclampsia in Yahyanejad Hospital from 1998 to 2008...
2014: Clinical and Experimental Obstetrics & Gynecology
Samina Naseem Khattak, Farhat Deeba, Attiya Ayaz, Muhammad Irfan Khattak
BACKGROUND: Placental abruption is one of the leading causes of maternal mortality and morbidity. Many causes predispose an expecting mother to placental abruption, such as trauma, previous history, smoking, ethnicity and hypertension. The present study concentrated on maternal hypertension as a cause of abruption. METHODS: All subjects of this comparative study underwent a complete obstetrical clinical workup comprising history, general physical examination, abdominal and pelvic examination, and relevant investigations...
July 2012: Journal of Ayub Medical College, Abbottabad: JAMC
Aimin Wang, Juan Ren, Christina P Wang, Vincent C Hascall
Growth-arrested rat mesangial cells (RMCs) at a G0/G1 interphase stimulated to divide in hyperglycemic medium initiate intracellular hyaluronan synthesis that induces autophagy/cyclin D3-induced formation of a monocyte-adhesive extracellular hyaluronan matrix after completing cell division. This study shows that heparin inhibits the intracellular hyaluronan synthesis and autophagy responses, but at the end of cell division it induces synthesis of a much larger extracellular monocyte-adhesive hyaluronan matrix...
March 28, 2014: Journal of Biological Chemistry
C V Nolan, Z A Shaikh
Although the analysis of metallothionein (MT) by radioimmunoassay (RIA) is not a common technique, its use is preferred over other methods since it offers the advantages of sensitivity and specificity. In this paper we present data on the basal levels of MT in rat tissues and physiological fluids of female Sprague-Dawley rats. The mean basal MT concentrations of the following organs and fluids were determined by RIA to be: liver (9.8 μg/g), kidney (68 μ/g), brain (0.8 μg/g), spleen (1.0 μg/g), heart (5...
April 1987: Biological Trace Element Research
V M Baev, D B Kozlov
AIM: To estimate changes in renal function in patients with acute hypertensive encephalopathy (AHE) during standard inpatient antihypertensive therapy. SUBJECTS AND METHODS: Patients were selected for the trial in the cardiology and admission units of a Perm hospital. The group included 60 patients with AHE. The patients received inpatient antihypertensive therapy for 10-14 days. Within the first 2 hours, enalaprilate 1.25 mg was intravenously injected, by monitoring blood pressure...
2013: Terapevticheskiĭ Arkhiv
Nick Hornigold, Tim S Johnson, Linghong Huang, John L Haylor, Martin Griffin, Andrew Mooney
Glomerulosclerosis of any cause is characterized by loss of functional glomerular cells and deposition of excessive amounts of interstitial collagens including collagen I. We have previously reported that mesangial cell attachment to collagen I leads to upregulation of Hic-5 in vitro, which mediates mesangial cell apoptosis. Furthermore, glomerular Hic-5 expression was increased during the progression of experimental glomerulosclerosis. We hypothesized that reducing collagen I accumulation in glomerulosclerosis would in turn lower Hic-5 expression, reducing mesangial cell apoptosis, and thus maintaining glomerular integrity...
May 2013: Laboratory Investigation; a Journal of Technical Methods and Pathology
James Palmier, Brian J Lanzrath
OBJECTIVES: Identification of statistically significant laboratory and biometric predictors of cancer-related mortality among insured individuals. BACKGROUND: Numerous clinical studies have identified correlations between various laboratory results and physical measurements and cancer risk, often of a uni-variate nature. A study of life insurance claims has permitted a broad multivariate analysis of laboratory and biometric risk factors for cancer mortality in an insured population...
2012: Journal of Insurance Medicine
Shizuka Aritomi, Kazumi Niinuma, Tetsuya Ogawa, Tomoyuki Konda, Kosaku Nitta
BACKGROUND: Cilnidipine (Cil) is an L/N-type calcium channel blocker (CCB) that is known to provide renal protection by decreasing the activity of the sympathetic nervous system and the renin-angiotensin system (RAS). However, very few studies have evaluated the renoprotective effects of Cil in hypertension complicated by diabetes mellitus. In this study, we compared the effects of cilnidipine and the L-type CCB, amlodipine (Aml), in combination with an angiotensin II receptor blocker (ARB) on diabetic nephropathy that developed as a result of inducing diabetes in hypertensive rats...
February 2013: Clinical and Experimental Nephrology
Ismail Seckin, Mumin Uzunalan, Meltem Pekpak, Sibel Kokturk, Huseyin Sonmez, Zeynep Oztürk, Sibel Demirci, Elif Yaprak
BACKGROUND: In experimentally induced puromycine aminonucleoside nephrosis (PAN) animal models, nephrotic syndrome with minimal change disease and focal and segmental sclerosis-like nephritis similar to that in human is demonstrated; however, the real mechanism of PAN is not yet elucidated. Platelet derived endothelial cell growth factor (PD-ECGF), an endothelial mitogen protein, is believed to take part in microvessel formation and in stimulation of angiogenesis and its expression has not been totally demonstrated in PAN rats yet...
2012: Journal of Biomedical Science
P I Novikov, O G Krivosheev, E N Semenkova
AIM: To assess efficacy of rituximab in patients suffering from Wegener's granulematosis (WG) with renal disease. MATERIAL AND METHODS: We analysed clinical laboratory data from 9 WG patients with renal disease treated with rituximab in E.M. Tareev clinic. RESULTS: The treatment led to a complete remission in 7 (77.8%) patients, a partial remission--in 2 (22.2%) patients. Vasculitis activity regressed including renal damage (a decrease of 24 h proteinurea, enhanced glomerular filtration rate)...
2011: Terapevticheskiĭ Arkhiv
Jörg Slany
UNLABELLED: There is little evidence from controlled prospective studies to support the low blood pressure goals stipulated for the treatment of hypertension by present guidelines, especially in high-risk patients with diabetes, renal insufficiency or coronary heart disease. Aim of this review is to scrutinize the potential benefit and risk of low blood pressure on the basis of recent studies and secondary analyses of older studies. RESULTS: In patients with coronary heart disease or equivalent or with diabetes lowering systolic blood pressure to 130 to 135 mmHg reduced primary or secondary cardiovascular endpoints in the majority of studies...
October 2011: Wiener Klinische Wochenschrift
I G Rekhtina, E P Golitsina, L S Biriukova
A rare variant of nephropathy in multiple myeloma (MM) is reported. Nephropathy is characterized basing on the study of nephrobiopsy with light, immunofluorescent and electron microscopy. A repeat biopsy of the kidney was made after achievement of a complete clinicohematological remission. A MM patient's nephrobiopsy in a picture of glomerulonephritis had 3 types of deposits: granular, irregular fibrils of 12 nm in diameter and microtubes organized in bunches 19 nm in diameter. Congo red test was negative, cryoglobulinemia was absent...
2011: Terapevticheskiĭ Arkhiv
Masabumi Shibuya
We previously isolated a novel tyrosine kinase receptor, Flt-1, now known as VEGF-receptor (VEGFR)-1. The VEGF-VEGFR system plays a pivotal role in not only physiological but also pathological angiogenesis. We examined the role of Flt-1 in carcinogenesis using Flt-1-signal-deficient (Flt-1 TK-/-) mice, and found that this receptor stimulates tumor growth and metastasis most likely via macrophages, making it an important potential target in the treatment of cancer. In addition to the full-length receptor, the Flt-1 gene produces a soluble protein, sFlt-1, an endogenous VEGF-inhibitor...
2011: Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
Razieh Mohammadjafari, Parvin Abedi, Syfolah Belady, Tarlan Hamidehkho, Taghi Razi
The present case study is on a 16-year-old woman who was suffering from nephrotic syndrome after recovery from complete type of hydatiform mole. She was admitted in hospital because of proteinurea and hematuria. Then she was showing a generalized edema compatible with neprhotic syndrome. In her past medical history she had a suction curettage for hydatiform mole. After she received 4 courses chemotherapy, she completely recovered and βhCG has fallen from 12127 IU/L to under 10 IU/mL. Then she showed generalized edema, proteinurea and hematuria compatible with nephritic syndrome...
2010: Rare Tumors
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