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https://www.readbyqxmd.com/read/28092867/expression-of-mmp-2-and-timp-1-during-rapid-maxillary-expansion-in-rats
#1
Jianwei Chen, Jing Zhou, Fan Li, Jianfeng Sun, Guifeng Li, Shujuan Zou, Qingsong Ye
OBJECTIVE: The aim of this study was to investigate the expression of MMP-2 and TIMP-1 during midpalatal suture expansion in rats. DESIGN: 72 male Wistar rats were randomly divided into 2 groups: the experimental group and the control group. In the experimental group, opening loops were applied across the midpalatal suture with an initial force of 50g, whereas in the control group, rats were subjected to sham installation of opening loops without activation. On day 1, 4, 7 and 14, nine rats from each group were sacrificed, and the maxillae were dissected and prepared for Immunohistochemistry (IHC) and RT- PCR examination of MMP-2 and TIMP-1 expression...
January 4, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28092791/minor-physical-anomalies-in-bipolar-i-and-bipolar-ii-disorders-results-with-the-m%C3%A3-hes-scale
#2
Hajnalka Berecz, Györgyi Csábi, Sára Jeges, Róbert Herold, Maria Simon, Tamás Halmai, Dániel Trixler, András Hajnal, Ákos Levente Tóth, Tamás Tényi
Minor physical anomalies (MPAs) are external markers of abnormal brain development, so the more common appearence of these signs among bipolar I and bipolar II patients can confirm the possibility of a neurodevelopmental deficit in these illnesses. The aim of the present study was to investigate the rate and topological profile of minor physical anomalies in patients with bipolar I and - first in literature - with bipolar II disorders compared to matched healthy control subjects. Using a list of 57 minor physical anomalies (the Méhes Scale), 30 bipolar I and 30 bipolar II patients, while as a comparison 30 matched healthy control subjects were examined...
January 5, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28092164/comparing-modified-huddart-bodenham-scoring-system-and-goslon-yardstick-to-assess-dental-arch-relationships-in-unilateral-cleft-lip-and-palate-patients
#3
Muhaini Yakob, H Yang Rafidah, M Gu, Y Yang
OBJECTIVE:   To test the reliability of the modified Huddart-Bodenham (MHB) numerical scoring system and its agreement with the GOSLON Yardstick categorization for assessing the dental arch relationships in unilateral cleft lip and palate (UCLP) cases. DESIGN:   A retrospective study. SETTING:   Faculty of Dentistry, The University of Hong Kong. PATIENTS:   Forty-one nonsyndromic UCLP consecutive patients attending the Joint Cleft Lip/Palate Clinic at Faculty of Dentistry in the University of Hong Kong were selected...
January 16, 2017: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/28092094/comparison-and-evaluation-of-stresses-generated-by-rapid-maxillary-expansion-and-the-implant-supported-rapid-maxillary-expansion-on-the-craniofacial-structures-using-finite-element-method-of-stress-analysis
#4
Varun Jain, Tarulatha R Shyagali, Prabhuraj Kambalyal, Yagnesh Rajpara, Jigar Doshi
BACKGROUND: The study aimed to evaluate and compare the stress distribution and 3-dimensional displacements along the craniofacial sutures in between the Rapid maxillary Expansion (RME) and Implant supported RME (I-RME). METHODS: Finite element model of the skull and the implants were created using ANSYS software. The finite element model thus built composed of 537692 elements and 115694 nodes in RME model & 543078 elements and 117948 nodes with implants model. The forces were applied on the palatal surface of the posterior teeth to cause 5mm of transverse displacement on either side of the palatal halves, making it a total of 10mm...
December 2017: Progress in Orthodontics
https://www.readbyqxmd.com/read/28089926/sensory-specific-satiety-is-intact-in-rats-made-obese-on-a-high-fat-high-sugar-choice-diet
#5
Kevin P Myers
Sensory-specific satiety (SSS) is the temporary decreased pleasantness of a recently eaten food, which inhibits further eating. Evidence is currently mixed whether SSS is weaker in obese people, and whether such difference precedes or follows from the obese state. Animal models allow testing whether diet-induced obesity causes SSS impairment. Female rats (n = 24) were randomly assigned to an obesogenic high-fat, high-sugar choice diet or chow-only control. Tests of SSS involved pre-feeding a single palatable, distinctively-flavored food (cheese- or cocoa-flavored) prior to free choice between both foods...
January 12, 2017: Appetite
https://www.readbyqxmd.com/read/28089335/intrusion-of-maxillary-molar-using-mini-implants-a-clinical-report-and-follow-up-at-5-years
#6
Célia Regina Maio Pinzan-Vercelino, Fausto Silva Bramante, Júlio de Araújo Gurgel, Eliane Cristina Carrera Eleres Vergani, Rosyane de Souza Gregório
This clinical report describes a straightforward alternative treatment for adult patients with extruded maxillary molars, who are reluctant to use fixed appliances and complex mechanics. The maxillary molar supereruption of a 57-year-old woman was treated using buttons bonded to the buccal and palatal surfaces of the molars, 2 mini-implants, and elastomeric chains. The intrusion was achieved in 5 months. The treatment stability was observed for 5 years after treatment.
January 12, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28088314/is-advanced-paternal-age-a-health-risk-for-the-offspring
#7
REVIEW
Anne-Marie Nybo Andersen, Stine Kjaer Urhoj
In this article we review the epidemiologic evidence for adverse health effects in offspring of fathers of advanced age. First the evidence regarding fetal survival is addressed, and afterward we review the evidence regarding morbidity in children with older fathers. The adverse conditions most consistently associated with increased paternal age are stillbirths, musculo-skeletal syndromes, cleft palate, acute lymphoblastic leukemia and retinoblastoma, and neurodevelopmental disorders in the autism spectrum and schizophrenia...
January 11, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28087736/imputation-of-orofacial-clefting-data-identifies-novel-risk-loci-and-sheds-light-on-the-genetic-background-of-cleft-lip-%C3%A2-cleft-palate-and-cleft-palate-only
#8
Kerstin U Ludwig, Anne C Böhmer, John Bowes, Miloš Nikolić, Nina Ishorst, Niki Wyatt, Nigel L Hammond, Lina Gölz, Frederic Thieme, Sandra Barth, Hannah Schuenke, Johanna Klamt, Malte Spielmann, Khalid Aldhorae, Augusto Rojas-Martinez, Markus M Nöthen, Alvaro Rada-Iglesias, Michael J Dixon, Michael Knapp, Elisabeth Mangold
Nonsyndromic cleft lip with or without cleft palate (nsCL/P) is among the most common human birth defects with multifactorial etiology. Here, we present results from a genome-wide imputation study of nsCL/P in which, after adding replication cohort data, four novel risk loci for nsCL/P are identified (at chromosomal regions 2p21, 14q22, 15q24 and 19p13). On a systematic level, we show that the association signals within this high-density dataset are enriched in functionally-relevant genomic regions that are active in both human neural crest cells (hNCC) and mouse embryonic craniofacial tissue...
January 13, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28086763/the-prevalence-and-factors-associated-with-malnutrition-among-infants-with-cleft-palate-and-or-lip-at-a-hospital-in-uganda-a-cross-sectional-study
#9
Martin Tungotyo, Daniel Atwine, Deborah Nanjebe, Andrew Hodges, Martin Situma
BACKGROUND: To determine the prevalence and factors associated with malnutrition among infants with Cleft palate and/or cleft lip (CP+/-L) at Comprehensive Rehabilitation for Uganda Hospital (CoRSU) in Uganda. METHODS: This was a cross-sectional study done on infants with CP+/-L and their caretakers admitted between November 2013 and October 2014 at CoRSU hospital which was the study setting. A questionnaire was answered by the infants' caretakers. The main outcome measure, malnutrition was defined and classified based on Z-scores obtained using the W...
January 13, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28081307/the-demographics-and-histopathological-features-of-oral-cavity-cancers-in-turkey
#10
Mehmet Düzlü, Recep Karamert, Faruk Kadri Bakkal, Raşit Cevizci, Hakan Tutar, Mehmet Ekrem Zorlu, Alper Dilci, Fakih Cihat Eravcı
BACKGROUND/AIM: This study aimed to examine the demographics and histopathological features of oral cavity cancers (OCCs) managed in our clinic. MATERIALS AND METHODS: Patients who were diagnosed with OCCs in the Gazi University Otorhinolaryngology Department between the years 1993 and 2013 were retrospectively enrolled in the study. Surgical archive charts and pathology records were reviewed in detail regarding the anatomical and histopathological profiles of the tumors, as well as the demographic data of the patients...
December 20, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28081210/mutations-in-hyal2-encoding-hyaluronidase-2-cause-a-syndrome-of-orofacial-clefting-and-cor-triatriatum-sinister-in-humans-and-mice
#11
Martina M A Muggenthaler, Biswajit Chowdhury, S Naimul Hasan, Harold E Cross, Brian Mark, Gaurav V Harlalka, Michael A Patton, Miho Ishida, Elijah R Behr, Sanjay Sharma, Kenneth Zahka, Eissa Faqeih, Brian Blakley, Mike Jackson, Melissa Lees, Vernon Dolinsky, Leroy Cross, Philip Stanier, Claire Salter, Emma L Baple, Fowzan S Alkuraya, Andrew H Crosby, Barbara Triggs-Raine, Barry A Chioza
Orofacial clefting is amongst the most common of birth defects, with both genetic and environmental components. Although numerous studies have been undertaken to investigate the complexities of the genetic etiology of this heterogeneous condition, this factor remains incompletely understood. Here, we describe mutations in the HYAL2 gene as a cause of syndromic orofacial clefting. HYAL2, encoding hyaluronidase 2, degrades extracellular hyaluronan, a critical component of the developing heart and palatal shelf matrix...
January 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28080910/use-of-computed-tomography-for-investigation-of-rhinitis-and-sinusitis-in-a-greater-rhea-rhea-americana
#12
Anne M Meyer, Kristen Phair, Gary West
Sinusitis is a common finding in avian species; however, it presents unique treatment challenges in ratites. A 6-yr-old male greater rhea ( Rhea americana ) presented acutely with right infraorbital sinus swelling and chemosis. Oral antibiotics were prescribed based on bacterial culture results with incomplete resolution of clinical signs. A computed tomography scan of the skull demonstrated a mixed-density soft tissue mass with extensive destruction of the right nasal bone, hard palate, maxilla, and frontal bone...
December 2016: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28079611/it-is-just-attention-deficit-hyperactivity-disorder%C3%A2-or-is-it
#13
Dana C Won, Christian Guilleminault, Peter J Koltai, Stacey D Quo, Martin T Stein, Irene M Loe
Carly is a 5-year-old girl who presents for an interdisciplinary evaluation due to behaviors at school and home suggestive of attention-deficit hyperactivity disorder (ADHD). Parent report of preschool teacher concerns was consistent with ADHD. Psychological testing showed verbal, visual-spatial, and fluid reasoning IQ scores in the average range; processing speed and working memory were below average. Carly's behavior improved when her mother left the room, and she was attentive during testing with a psychologist...
January 10, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28077705/processing-of-intraoral-olfactory-and-gustatory-signals-in-the-gustatory-cortex-of-awake-rats
#14
Chad L Samuelsen, Alfredo Fontanini
: The integration of gustatory and olfactory information is essential to the perception of flavor. Human neuroimaging experiments have pointed to the gustatory cortex (GC) as one of the areas involved in mediating flavor perception. Although GC's involvement in encoding the chemical identity and hedonic value of taste stimuli is well studied, it is unknown how single GC neurons process olfactory stimuli emanating from the mouth. In this study, we relied on multielectrode recordings to investigate how single GC neurons respond to intraorally delivered tastants and tasteless odorants dissolved in water and whether/how these two modalities converge in the same neurons...
January 11, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28077415/international-multiphase-mixed-methods-study-protocol-to-develop-a-cross-cultural-patient-reported-outcome-instrument-for-children-and-young-adults-with-cleft-lip-and-or-palate-cleft-q
#15
Karen W Y Wong Riff, Elena Tsangaris, Tim Goodacre, Christopher R Forrest, Andrea L Pusic, Stefan J Cano, Anne F Klassen
INTRODUCTION: Patient-reported outcome (PRO) instruments should be developed according to rigorous guidelines in order to provide clinically meaningful, scientifically sound measurement. Understanding the methodology behind instrument development informs the selection of the most appropriate tool. This mixed methods protocol describes the development of an internationally applicable PRO instrument, the CLEFT-Q, for evaluating outcomes of treatment for cleft lip and/or palate (CL/P). METHODS AND ANALYSIS: The study includes three main phases that occur iteratively and interactively...
January 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28077246/testing-of-a-palatable-bait-and-compatible-vaccine-carrier-for-the-oral-vaccination-of-european-badgers-meles-meles-against-tuberculosis
#16
Sonya Gowtage, Gareth A Williams, Ray Henderson, Paul Aylett, Duncan MacMorran, Si Palmer, Andy Robertson, Sandrine Lesellier, Stephen P Carter, Mark A Chambers
The oral vaccination of wild badgers (Meles meles) with live Bacillus Calmette-Guérin (BCG) is one of the tools being considered for the control of bovine tuberculosis (caused by Mycobacterium bovis) in the UK. The design of a product for oral vaccination requires that numerous, and often competing, conditions are met. These include the need for a highly palatable, but physically stable bait that will meet regulatory requirements, and one which is also compatible with the vaccine formulation; in this case live BCG...
January 9, 2017: Vaccine
https://www.readbyqxmd.com/read/28076598/minor-intraoral-salivary-gland-tumors-a-clinical-pathological-study
#17
Dmitry José de Santana Sarmento, Maria de Lourdes Silva de Arruda Morais, Antonio de Lisboa Lopes Costa, Éricka Janine Dantas da Silveira
Objective: To evaluate the clinical-pathological profile of patients with minor salivary gland neoplasms. Methods: A retrospective study of specific cases diagnosed as benign and malignant tumors of the minor salivary glands was performed. The data were collected from medical records of patients seen at a hospital over a period of 15 years. The sample was made up of 37 cases. For the pathological study, slides containing 5μm thick sections stained with hematoxylin and eosin were used...
October 2016: Einstein
https://www.readbyqxmd.com/read/28076458/risk-of-developing-palatally-displaced-canines-in-patients-with-early-detectable-dental-anomalies-a-retrospective-cohort-study
#18
Daniela Gamba Garib, Melissa Lancia, Renata Mayumi Kato, Thais Marchini Oliveira, Lucimara Teixeira das Neves
Objective: To estimate the risk of PDC occurrence in children with dental anomalies identified early during mixed dentition. Material and Methods: The sample comprised 730 longitudinal orthodontic records from children (448 females and 282 males) with an initial mean age of 8.3 years (SD=1.36). The dental anomaly group (DA) included 263 records of patients with at least one dental anomaly identified in the initial or middle mixed dentition. The non-dental anomaly group (NDA) was composed of 467 records of patients with no dental anomalies...
November 2016: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28075445/a-clinical-and-molecular-analysis-of-a-patient-with-emanuel-syndrome
#19
Jin-Wen Luo, Huan Yang, Zhi-Ping Tan, Ming Tu, Hong Luo, Yi-Feng Yang, Li Xie
Emanuel syndrome (ES) is the most frequent type of recurrent non‑Robertsonian translocation that is characterized by numerous anomalies. Over 100 patients with ES have been described in the literature. The phenotype of this syndrome varies but often consists of facial dysmorphism, microcephaly, severe intellectual disability, developmental retardation, congenital heart disease and genital anomalies. The present study describes a 2‑year‑old boy with multiple malformations, including facial dysmorphism, severe intellectual disability, growth retardation, congenital heart disease, cleft lip and palate, genital malformation (micropenis), amblyopia, thymic dysplasia and hearing impairment...
January 5, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28074348/challenges-and-opportunities-in-the-development-of-hiv-medications-in-pediatric-patients
#20
Gueorgui Dubrocq, Natella Rakhmanina, B Ryan Phelps
Successful management of pediatric HIV disease requires high therapeutic efficacy and adherence, which can be achieved by providing affordable, easy to store, and palatable antiretrovirals. Current challenges in pediatric antiretroviral drug development include poor palatability, large pill size, limited oral liquid formulations, and few incentives for development by drug manufacturers as the number of children with HIV continues to decline due to successful worldwide preventive interventions and improved access to antiretrovirals...
January 10, 2017: Paediatric Drugs
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