Chih-Yuan Ko, Yen-You Lin, David Achudhan, Jun-Way Chang, Shan-Chi Liu, Chao-Yang Lai, Yuan-Li Huang, Chun-Hao Tsai, Yi-Chin Fong, Hsien-Te Chen, Kun-Tsan Lee, Chien-Chung Huang, Ting-Kuo Chang, Chih-Hsin Tang
Osteoarthritis (OA) is a prevalent joint disease commonly associated with aging and obesity, which can lead to pain, stiffness, joint dysfunction, and disability. Omentin-1 (also called intelectin-1) is a newly discovered adipokine, which plays a protective role in suppressing the secretion of pro-inflammatory cytokines. Based on data from the Gene Expression Omnibus (GEO) dataset and clinical samples obtained at our institution revealed, determined that omentin-1 and IL-4 (an anti-inflammatory cytokine) levels were significantly lower in OA patients than in normal controls...
2023: International Journal of Biological Sciences