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Erosive Osteoarthritis

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https://www.readbyqxmd.com/read/28544753/no-association-between-metabolic-syndrome-and-radiographic-hand-osteoarthritis-data-from-the-framingham-study
#1
Mette P Strand, Tuhina Neogi, Jingbo Niu, David T Felson, Ida K Haugen
OBJECTIVE: To explore whether metabolic syndrome (MetS) and its components are associated with hand OA using longitudinal data from the Framingham study. METHODS: In our cross-sectional analyses we included 1089 persons (age 50-75 years), of whom 785 had 7-year longitudinal radiographs. Of these, 586 with no hand OA at baseline were included in analyses on hand OA incidence. We explored associations between and MetS and its components (central obesity, hypertension, diabetes, triglyceridemia, low high-density lipoprotein) and radiographic hand OA (defined as ≥2 interphalangeal joints with Kellgren-Lawrence grade≥2) using logistic regression analyses with adjustment for age, sex and body mass index (BMI)...
May 23, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28536825/intramuscular-clodronate-in-erosive-osteoarthritis-of-the-hand-is-effective-on-pain-and-reduces-serum-comp-a-randomized-pilot-trial-the-er-o-d-e-study-erosive-osteoarthritis-and-disodium-clodronate-evaluation
#2
Gianantonio Saviola, Lul Abdi-Ali, Maria Rosaria Povino, Lorella Campostrini, Silvano Sacco, Luca Dalle Carbonare
We evaluated the efficacy and safety of intramuscular clodronate (CLO) for the treatment of active erosive osteoarthritis of the hand (EOA). Forty outpatients treated with anti-inflammatory (NSAIDs) or analgesic drugs since at least 6 months, for at least 3 days a week, were randomly divided into two groups. Group A: 24 patients treated for 6 months with intramuscular (i.m.) CLO added to usual NSAIDs or analgesic drugs. The attack dose was 200 mg/day i.m. for 10 days followed by a maintenance dose of CLO i...
May 23, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28512004/contribution-of-high-resolution-peripheral-quantitative-ct-to-the-management-of-bone-and-joint-diseases
#3
Eric Lespessailles, Nada Ibrahim-Nasser, Hechmi Toumi, Roland Chapurlat
Many imaging modalities have been described to diagnose and monitor osteoporosis (OP), osteoarthritis and inflammatory rheumatic diseases. Over the last ten years, High Resolution peripheral Quantitative Computerized Tomography (HR-pQCT) was shown to be a precise and non invasive technique to study bone and joint diseases in clinical research. It allows the study of both cortical and trabecular bone microarchitecture at the distal tibia and radius, and further applications have been developed such as the study of mechanical properties by the finite element analysis...
May 13, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/28510594/long-term-type-1-diabetes-is-associated-with-hand-pain-disability-and-stiffness-but-not-with-structural-hand-osteoarthritis-features-the-dialong-hand-study
#4
Karin Magnusson, Kristine Bech Holte, Niels Gunnar Juel, Jens Ivar Brox, Kåre Birger Hagen, Ida Kristin Haugen, Tore Julsrud Berg
OBJECTIVE: To explore whether having long-term type 1 diabetes (>45 years) is associated with a higher prevalence of radiographic hand OA, erosive hand OA and increased hand pain, disability and stiffness. METHODS: In total N = 96 persons with type 1 diabetes diagnosed before 1970 were included (mean [SD] age: 62.2 [7.4], mean [SD] HbA1c: 7.43 [0.80] and N = 49 [51%] men). Regular measurements of their HbA1c were obtained till 2015. We included N = 69 healthy controls without any diabetes (mean [SD] age: 63...
2017: PloS One
https://www.readbyqxmd.com/read/28473097/acr-appropriateness-criteria-%C3%A2-chronic-extremity-joint-pain-suspected-inflammatory-arthritis
#5
Jon A Jacobson, Catherine C Roberts, Jenny T Bencardino, Marc Appel, Erin Arnold, Steven J Baccei, R Carter Cassidy, Eric Y Chang, Michael G Fox, Bennett S Greenspan, Soterios Gyftopoulos, Mary G Hochman, Douglas N Mintz, Joel S Newman, Zehava S Rosenberg, Nehal A Shah, Kirstin M Small, Barbara N Weissman
Evaluation for suspected inflammatory arthritis as a cause for chronic extremity joint pain often relies on imaging. This review first discusses the characteristic osseous and soft tissue abnormalities seen with inflammatory arthritis and how they may be imaged. It is essential that imaging results are interpreted in the context of clinical and serologic results to add specificity as there is significant overlap of imaging findings among the various types of arthritis. This review provides recommendations for imaging evaluation of specific types of inflammatory arthritis, including rheumatoid arthritis, seronegative spondyloarthropathy, gout, calcium pyrophosphate dihydrate disease (or pseudogout), and erosive osteoarthritis...
May 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28250145/development-and-reliability-of-the-omeract-thumb-base-osteoarthritis-magnetic-resonance-imaging-scoring-system
#6
Féline P B Kroon, Philip G Conaghan, Violaine Foltz, Frédérique Gandjbakhch, Charles Peterfy, Iris Eshed, Harry K Genant, Mikkel Østergaard, Margreet Kloppenburg, Ida K Haugen
OBJECTIVE: To develop the Outcome Measures in Rheumatology (OMERACT) thumb base osteoarthritis (OA) magnetic resonance imaging (MRI) scoring system (TOMS) for the assessment of inflammatory and structural abnormalities in this hand OA subset, and test its cross-sectional reliability. METHODS: Included features and their scaling were agreed upon by members of the OMERACT MRI Task Force using the Hand OA MRI scoring system as a template. A reliability exercise was performed in which 3 readers participated, using a preliminary atlas with examples to facilitate reading...
March 1, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28181577/age-dependent-changes-in-the-articular-cartilage-and-subchondral-bone-of-c57bl-6-mice-after-surgical-destabilization-of-medial-meniscus
#7
Henry Huang, Jordan D Skelly, David C Ayers, Jie Song
Age is the primary risk factor for osteoarthritis (OA), yet surgical OA mouse models such as destabilization of the medial meniscus (DMM) used for evaluating disease-modifying OA targets are frequently performed on young adult mice only. This study investigates how age affects cartilage and subchondral bone changes in mouse joints following DMM. DMM was performed on male C57BL/6 mice at 4 months (4 M), 12 months (12 M) and 19+ months (19 M+) and on females at 12 M and 18 M+. Two months after surgery, operated and unoperated contralateral knees were harvested and evaluated using cartilage histology scores and μCT quantification of subchondral bone plate thickness and osteophyte formation...
February 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28167247/results-and-limitations-of-humeral-head-resurfacing-105-cases-at-a-mean-follow-up-of-5-years
#8
K Soudy, C Szymanski, C Lalanne, C Bourgault, A Thiounn, A Cotten, C Maynou
BACKGROUND: The objective of this study was to assess clinical and computed-tomography (CT) outcomes at least 2 years after humeral head resurfacing to treat concentric gleno-humeral osteoarthritis. HYPOTHESIS: Humeral head resurfacing provides similar outcomes to those achieved with stemmed humeral head implants. MATERIALS AND METHODS: This single-centre retrospective study included 40 Copeland™ and 65 Aequalis™ humeral resurfacing heads implanted between 2004 and 2012...
May 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28161769/radiographic-involvement-of-metacarpophalangeal-and-radiocarpal-joints-in-hand-osteoarthritis
#9
Olga Addimanda, Carlotta Cavallari, Elettra Pignotti, Lia Pulsatelli, Luana Mancarella, Roberta Ramonda, Antonella Fioravanti, Riccardo Meliconi
To evaluate, by means of a longitudinal study, radiographic involvement of metacarpophalangeal and radio-carpal joints in hand osteoarthritis, its relationship with erosive disease and its progression, 368 patients with hand osteoarthritis were enrolled. All patients underwent hand X-rays. On the basis of the presence of central erosions in interphalangeal joints, patients were divided into three groups: 0-no central erosions, 1-one joint with central erosion, and 2-two or more joints with central erosions...
February 4, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28150695/characterisation-of-a-divergent-progenitor-cell-sub-populations-in-human-osteoarthritic-cartilage-the-role-of-telomere-erosion-and-replicative-senescence
#10
Christopher R Fellows, Rebecca Williams, Iwan R Davies, Kajal Gohil, Duncan M Baird, John Fairclough, Paul Rooney, Charles W Archer, Ilyas M Khan
In recent years it has become increasingly clear that articular cartilage harbours a viable pool of progenitor cells and interest has focussed on their role during development and disease. Analysis of progenitor numbers using fluorescence-activated sorting techniques has resulted in wide-ranging estimates, which may be the result of context-dependent expression of cell surface markers. We have used a colony-forming assay to reliably determine chondroprogenitor numbers in normal and osteoarthritic cartilage where we observed a 2-fold increase in diseased tissue (P  < 0...
February 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28108560/cxcr3-cxcl10-axis-regulates-neutrophil-nk-cell-cross-talk-determining-the-severity-of-experimental-osteoarthritis
#11
Giorgia Benigni, Petya Dimitrova, Fabrizio Antonangeli, Emilio Sanseviero, Viktoriya Milanova, Arjen Blom, Peter van Lent, Stefania Morrone, Angela Santoni, Giovanni Bernardini
Several immune cell populations are involved in cartilage damage, bone erosion, and resorption processes during osteoarthritis. The purpose of this study was to investigate the role of NK cells in the pathogenesis of experimental osteoarthritis and whether and how neutrophils can regulate their synovial localization in the disease. Experimental osteoarthritis was elicited by intra-articular injection of collagenase in wild type and Cxcr3(-/-) 8-wk old mice. To follow osteoarthritis progression, cartilage damage, synovial thickening, and osteophyte formation were measured histologically...
January 20, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28090062/ankylosis-of-the-finger-in-erosive-osteoarthritis
#12
Naoho Takizawa, Takuya Hamada, Yoshiro Fujita
No abstract text is available yet for this article.
2017: Internal Medicine
https://www.readbyqxmd.com/read/28089255/characterization-of-the-walch-b3-glenoid-in-primary-osteoarthritis
#13
Kevin Chan, Nikolas K Knowles, Jean Chaoui, Marc-Olivier Gauci, Louis M Ferreira, Gilles Walch, George S Athwal
BACKGROUND: The type B3 glenoid is an addition to the Walch classification. A potential etiologic theory is that it is a progression of the B2. It is characterized by uniconcavity, absent paleoglenoid, medialization, retroversion, and subluxation. The purpose of this study was to describe the morphology of B3 glenoids. METHODS: Fifty-two patients with B3 glenoids underwent 3-dimensional analysis of computed tomography data. Glenoid measurements (retroversion, inclination, medialization) and humeral head subluxation according to the scapular and glenoid planes were determined...
January 11, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28054155/radiological-and-histological-analysis-of-two-replaced-interphalangeal-joints-with-active-subchondral-bone-resorption-in-erosive-hand-osteoarthritis-a-novel-mechanism
#14
Marta Favero, Giorgio Perino, Maria Luisa Valente, Cesare Tiengo, Roberta Ramonda
The aim of this study was to describe the histological features of erosive hand osteoarthritis (EHOA), which is considered an aggressive subset of hand osteoarthritis (OA) characterized by severe local inflammation and degeneration of the distal and proximal interphalangeal joints. Two patients with EHOA underwent replacement with a cement-free press fit ceramic prosthesis of a proximal interphalangeal joint (PIPJ). Clinical and radiological data were collected and histological examination was performed. Radiological examination with histological correlation showed complete erosion of the articular cartilage with focal presence of peripheral fibrocartilaginous resurfacing, sclerosis, and remodeling of the exposed bone, osteoclastic activity with resorptive lacunae in the subchondral bone and around degenerative fibromyxoid pseudocysts, coarse trabeculation of the cancellous bone, and marginal osteophytes...
January 4, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/27965260/ccl2-ccr2-but-not-ccl5-ccr5-mediates-monocyte-recruitment-inflammation-and-cartilage-destruction-in-osteoarthritis
#15
Harini Raghu, Christin M Lepus, Qian Wang, Heidi H Wong, Nithya Lingampalli, Francesca Oliviero, Leonardo Punzi, Nicholas J Giori, Stuart B Goodman, Constance R Chu, Jeremy B Sokolove, William H Robinson
OBJECTIVES: While various monocyte chemokine systems are increased in expression in osteoarthritis (OA), the hierarchy of chemokines and chemokine receptors in mediating monocyte/macrophage recruitment to the OA joint remains poorly defined. Here, we investigated the relative contributions of the CCL2/CCR2 versus CCL5/CCR5 chemokine axes in OA pathogenesis. METHODS: Ccl2-, Ccr2-, Ccl5- and Ccr5-deficient and control mice were subjected to destabilisation of medial meniscus surgery to induce OA...
May 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27940594/the-comparison-of-magnetic-resonance-imaging-and-radiographs-to-assess-structural-progression-over-5-years-in-hand-osteoarthritis
#16
Ida Kristin Haugen, Barbara Slatkowsky-Christensen, Karwan Faraj, Désirée van der Heijde, Tore Kristian Kvien
OBJECTIVE: The aim was to explore the agreement between 1.0 T MRI and conventional radiography (CR) to detect progression of hand OA over 5 years and the associations between structural progression and incident joint tenderness. METHODS: Paired radiographs and paired MRIs of the second-fifth IP joints of the dominant hand from 69 hand OA patients were read for osteophytes, joint space narrowing and erosions. Patients with two or more joints demonstrating progression of any structural feature(s) were classified as progressors per imaging modality...
December 10, 2016: Rheumatology
https://www.readbyqxmd.com/read/27928662/predictors-of-medium-term-clinical-outcomes-after-total-shoulder-arthroplasty
#17
Tim Leschinger, Patric Raiss, Markus Loew, Felix Zeifang
PURPOSE: The study aims to measure the relationship of potential clinical and radiographic predictors and medium-term clinical outcomes after total shoulder arthroplasty in primary osteoarthritis. MATERIALS AND METHODS: In a prospective follow-up study, preoperatively collected clinical and radiographic variables were recorded in 103 patients with an average age of 66 years (range 37-83 years) to measure their influence on the clinical outcome by use of the Constant score...
February 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/27917634/-hand-osteoarthritis
#18
Ladislav Šenolt
Hand osteoarthritis (OA) is a common chronic disorder causing pain and limitation of mobility of affected joints. The prevalence of hand OA increases with age and more often affects females. Clinical signs obviously do not correlate with radiographic findings - symptomatic hand OA affects approximately 26 % of adult subjects, but radiographic changes can be found in up to two thirds of females and half of males older than 55 years.Disease course differ among individual patients. Hand OA is a heterogeneous disease...
2016: Casopís Lékar̆ů C̆eských
https://www.readbyqxmd.com/read/27863298/butein-inhibits-il-1%C3%AE-induced-inflammatory-response-in-human-osteoarthritis-chondrocytes-and-slows-the-progression-of-osteoarthritis-in-mice
#19
Wenhao Zheng, Hui Zhang, Yonglong Jin, Quan Wang, Linwei Chen, Zhenhua Feng, Hua Chen, Yaosen Wu
Osteoarthritis (OA) is a progressive degenerative disease characterized by irreversible articular cartilage destruction. Butein, a polyphenolic compound isolated from the stem bark of cashews and Rhus verniciflua Stokes, has been reported to have anti-inflammatory effects. This study aimed to assess the effect of butein on human OA chondrocytes and mice OA models induced by destabilization of the medial meniscus (DMM). In vitro, human OA chondrocytes were pretreated with butein at 10, 50μM and subsequently stimulated with IL-1β (10ng/ml) for 24h...
January 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/27851983/osteopontin-inhibition-of-mir-129-3p-enhances-il-17-expression-and-monocyte-migration-in-rheumatoid-arthritis
#20
Chun-Hao Tsai, Shan-Chi Liu, Yu-Han Wang, Chen-Ming Su, Chien-Chung Huang, Chin-Jung Hsu, Chih-Hsin Tang
BACKGROUND: Osteopontin (OPN) is an important proinflammatory cytokine in rheumatoid arthritis (RA). Levels of OPN have been shown to be significantly correlated with interleukin-17 (IL-17) production and expression of Th17 cells in the synovial fluid of RA patients. Here, we investigated the role of OPN in monocyte migration, IL-17 production and osteoblasts. METHODS: OPN and IL-17 expression profiles in osteoarthritis (OA) and RA synovial fluid were determined by enzyme-linked immunosorbent assay (ELISA)...
February 2017: Biochimica et Biophysica Acta
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