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Erosive Osteoarthritis

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https://www.readbyqxmd.com/read/27917634/-hand-osteoarthritis
#1
Ladislav Šenolt
Hand osteoarthritis (OA) is a common chronic disorder causing pain and limitation of mobility of affected joints. The prevalence of hand OA increases with age and more often affects females. Clinical signs obviously do not correlate with radiographic findings - symptomatic hand OA affects approximately 26 % of adult subjects, but radiographic changes can be found in up to two thirds of females and half of males older than 55 years.Disease course differ among individual patients. Hand OA is a heterogeneous disease...
2016: Casopís Lékar̆ů C̆eských
https://www.readbyqxmd.com/read/27863298/butein-inhibits-il-1%C3%AE-induced-inflammatory-response-in-human-osteoarthritis-chondrocytes-and-slows-the-progression-of-osteoarthritis-in-mice
#2
Wenhao Zheng, Hui Zhang, Yonglong Jin, Quan Wang, Linwei Chen, Zhenhua Feng, Hua Chen, Yaosen Wu
Osteoarthritis (OA) is a progressive degenerative disease characterized by irreversible articular cartilage destruction. Butein, a polyphenolic compound isolated from the stem bark of cashews and Rhus verniciflua Stokes, has been reported to have anti-inflammatory effects. This study aimed to assess the effect of butein on human OA chondrocytes and mice OA models induced by destabilization of the medial meniscus (DMM). In vitro, human OA chondrocytes were pretreated with butein at 10, 50μM and subsequently stimulated with IL-1β (10ng/ml) for 24h...
November 14, 2016: International Immunopharmacology
https://www.readbyqxmd.com/read/27851983/osteopontin-inhibition-of-mir-129-3p-enhances-il-17-expression-and-monocyte-migration-in-rheumatoid-arthritis
#3
Chun-Hao Tsai, Shan-Chi Liu, Yu-Han Wang, Chen-Ming Su, Chien-Chung Huang, Chin-Jung Hsu, Chih-Hsin Tang
BACKGROUND: Osteopontin (OPN) is an important proinflammatory cytokine in rheumatoid arthritis (RA). Levels of OPN have been shown to be significantly correlated with interleukin-17 (IL-17) production and expression of Th17 cells in the synovial fluid of RA patients. Here, we investigated the role of OPN in monocyte migration, IL-17 production and osteoblasts. METHODS: OPN and IL-17 expression profiles in osteoarthritis (OA) and RA synovial fluid were determined by enzyme-linked immunosorbent assay (ELISA)...
November 13, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27847665/an-unusual-and-complicated-course-of-a-giant-cell-tumor-of-the-capitate-bone
#4
Ingo Schmidt
A 51-year-old female patient presented with a carpal giant cell tumor (GCT) of the right capitate bone. The lesion was initially misdiagnosed as having an osteomyelitis. First, the diagnosis of a benign GCT was confirmed by histological examination. Second, an intralesional curettage and packing of the cavity with cancellous iliac crest bone grafts combined with a fusion of the third carpometacarpal (CMC III) joint were carried out. Third, due to a secondary midcarpal osteoarthritis and a secondary scaphoid nonunion, the CMC III joint fusion plate was removed and the midcarpal joint completely excised...
2016: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/27820852/osteoarthritis-in-the-knee-joints-of-g%C3%A3-ttingen-minipigs-after-resection-of-the-anterior-cruciate-ligament-missing-correlation-of-mri-gene-and-protein-expression-with-histological-scoring
#5
Gregor Reisig, Michael Kreinest, Wiltrud Richter, Mechthild Wagner-Ecker, Dietmar Dinter, Ulrike Attenberger, Barbara Schneider-Wald, Stefan Fickert, Markus L Schwarz
INTRODUCTION: The Göttingen Minipig (GM) is used as large animal model in articular cartilage research. The aim of the study was to introduce osteoarthritis (OA) in the GM by resecting the anterior cruciate ligament (ACLR) according to Pond and Nuki, verified by histological and magnetic resonance imaging (MRI) scoring as well as analysis of gene and protein expression. MATERIALS AND METHODS: The eight included skeletally mature female GM were assessed after ACLR in the left and a sham operation in the right knee, which served as control...
2016: PloS One
https://www.readbyqxmd.com/read/27749237/mri-and-serum-biomarkers-correlate-with-radiographic-features-in-painful-hand-osteoarthritis
#6
Christian H Roux, Violaine Foltz, Emmanuel Maheu, Gabriel Baron, Frederique Gandjbakhch, Cédric Lukas, Daniel Wendling, Damien Loeuille, Pierre Lafforgue, Liana Euler-Ziegler, Pascal Richette, Xavier Chevalier
OBJECTIVES: To explore the relationship between clinical findings, biologic biomarkers, conventional radiography and MRI in patients with painful hand OA. METHODS: The following patient baseline data from the DORA study (evaluating anti-TNF-α agents against painful hand OA) were used: clinical assessment (pain, swelling, stiffness and function: Dreiser functional hand index [FIHOA] and Cochin hand functional scale [CHFS]); measurement of biomarkers (cartilage oligomeric matrix protein (COMP), type IIA collagen N-propeptid (PIINP), hyaluronic acid (HA), ultrasensitive C-reactive protein (usCRP), tumour necrosis factor (TNF), interleukin (IL)-6, IL-1β and urinary CTXII); radiological staging (Verbruggen, Kallman, Kellgren-Lawrence); anatomical evaluation by contrast-enhanced MRI of proximal and distal interphalangeal joints of dominant hand...
September 18, 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27698783/increased-receptor-activator-of-nuclear-factor-%C3%AE%C2%BA%C3%AE-ligand-osteoprotegerin-ratio-exacerbates-cartilage-destruction-in-osteoarthritis-in-vitro
#7
Ji-Zhou Zeng, Zhen-Zhong Wang, Li-Feng Ma, Hai Meng, Hao-Miao Yu, Wen-Hao Cheng, Ya-Kui Zhang, Ai Guo
Osteoarthritis (OA) is a degenerative joint disease characterized by progressive cartilage destruction, matrix degradation and bony changes. Subchondral bone alterations in osteoarthritis are associated with cartilage destruction. It has previously been demonstrated that osteoprotegerin (OPG) and receptor activator of nuclear factor κβ ligand (RANKL) mediate this process. The RANKL/OPG ratio is altered in OA chondrocytes compared with normal chondrocytes. In the pathogenesis of OA, abnormal expression levels of matrix metalloproteinase-13 (MMP-13) are secreted by chondrocytes has a vital role in the progression of cartilage erosion...
October 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27692966/erosive-osteoarthritis-a-systematic-analysis-of-definitions-used-in-the-literature
#8
David J Gazeley, Supraja Yeturi, Payal J Patel, Ann K Rosenthal
BACKGROUND: Erosive osteoarthritis (EOA) is a commonly invoked diagnosis representing an important variant of hand osteoarthritis (OA). There is increasing literature on the prevalence, risk factors, etiology, and management of EOA. METHODS: We systematically reviewed the literature to assess variability in the diagnostic definitions used to define EOA in these studies. RESULTS: We reviewed 336 articles and found 62 articles citing diagnostic definitions for EOA...
August 24, 2016: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/27668577/efficacy-of-intravenous-administration-of-hyaluronan-sodium-chondroitin-sulfate-and-n-acetyl-d-glucosamine-for-prevention-or-treatment-of-osteoarthritis-in-horses
#9
David D Frisbie, C Wayne McIlwraith, Christopher E Kawcak, Natasha M Werpy
OBJECTIVE To evaluate the efficacy of IV administration of a product containing hyaluronan, sodium chondroitin sulfate, and N-acetyl-d-glucosamine for prevention or treatment of osteoarthritis in horses. ANIMALS 32 healthy 2- to 5-year-old horses. PROCEDURES The study involved 2 portions. To evaluate prophylactic efficacy of the test product, horses received 5 mL of the product (n = 8) or saline (0.9% NaCl) solution (8; placebo) IV every fifth day, starting on day 0 (when osteoarthritis was induced in the middle carpal joint of 1 forelimb) and ending on day 70...
October 2016: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/27666624/single-source-dual-energy-computed-tomography-in-the-diagnosis-of-gout-diagnostic-reliability-in-comparison-to-digital-radiography-and-conventional-computed-tomography-of-the-feet
#10
Tobias Kiefer, Torsten Diekhoff, Sandra Hermann, Andrea Stroux, Jürgen Mews, Jörg Blobel, Bernd Hamm, Kay-Geert A Hermann
OBJECTIVES: To investigate the diagnostic value of single-source dual-energy computed tomography (SDECT) in gouty arthritis and to compare its capability to detect urate depositions with digital radiography (DR) and conventional computed tomography (CT). METHODS: Forty-four patients who underwent SDECT volume scans of the feet for suspected gouty arthritis were retrospectively analyzed. SDECT, CT (both n=44) and DR (n=36) were scored by three blinded readers for presence of osteoarthritis, erosions, and tophi...
October 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27664978/early-focal-changes-in-cartilage-cellularity-and-structure-following-surgically-induced-meniscal-destabilization-in-the-mouse
#11
Michael A David, Melanie K Smith, Rachael N Pilachowski, Avery T White, Ryan C Locke, Christopher Price
Post-traumatic osteoarthritis (PTOA) is an accelerated form of osteoarthritic cartilage degeneration affecting approximately 20-50% of patients experiencing joint injury. Currently PTOA is incurable; to better understand the etiology of PTOA and to develop rational anti-osteoarthritic therapies, it is critical to understand the spatiotemporal initiation and the progression of PTOA. In this study, we employed semi-quantitative histological scoring and quantitative damage analysis to examine disease progression in the murine destabilization of the medial meniscus (DMM) model of PTOA from early (3 days) through late- (112 days) disease timepoints...
September 24, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/27658905/efficacy-of-intra-articular-corticosteroid-injection-in-erosive-hand-osteoarthritis-infrared-thermal-imaging
#12
Marta Favero, Roberta Ramonda, Marco Rossato
No abstract text is available yet for this article.
September 22, 2016: Rheumatology
https://www.readbyqxmd.com/read/27658487/cellular-senescence-in-aging-and-osteoarthritis
#13
Wei Seong Toh, Mats Brittberg, Jack Farr, Casper Bindzus Foldager, Andreas H Gomoll, James Hoi Po Hui, James B Richardson, Sally Roberts, Myron Spector
- It is well accepted that age is an important contributing factor to poor cartilage repair following injury, and to the development of osteoarthritis. Cellular senescence, the loss of the ability of cells to divide, has been noted as the major factor contributing to age-related changes in cartilage homeostasis, function, and response to injury. The underlying mechanisms of cellular senescence, while not fully understood, have been associated with telomere erosion, DNA damage, oxidative stress, and inflammation...
September 23, 2016: Acta Orthopaedica
https://www.readbyqxmd.com/read/27632984/synovial-inflammation-drives-structural-damage-in-hand-osteoarthritis-a-narrative-literature-review
#14
Luana Mancarella, Olga Addimanda, Carlotta Cavallari, Riccardo Meliconi
BACKGROUND: Ultrasound is one of the most promising candidates for detection of inflammation and structural damage in hand osteoarthritis. OBJECTIVE: To evaluate new advances of US as a diagnostic and prognostic tool in hand osteoarthritis assessment. METHODS: We conducted a Medline on PubMed search for articles about "ultrasonography" and "hand OA" published between January 2012 and 15th April 2016, limiting our search to articles on human adults in English, excluding those involving inflammatory diseases, visualization of joints other than hands, ultrasound guided injections and surgical procedures...
September 9, 2016: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/27555371/apoptosis-signaling-pathways-in-osteoarthritis-and-possible-protective-role-of-melatonin
#15
Azam Hosseinzadeh, Seyed Kamran Kamrava, Mohammad Taghi Joghataei, Radbod Darabi, Ali Shakeri-Zadeh, Mansour Shahriari, Russel J Reiter, Habib Ghaznavi, Saeed Mehrzadi
Osteoarthritis (OA) is a degenerative joint disease characterized by progressive erosion of articular cartilage. As chondrocytes are the only cell type forming the articular cartilage, their gradual loss is the main cause of OA. There is a substantial body of published research that suggests reactive oxygen species (ROS) are major causative factors for chondrocyte damage and OA development. Oxidative stress elicited by ROS is capable of oxidizing and subsequently disrupting cartilage homeostasis, promoting catabolism via induction of cell death and damaging numerous components of the joint...
August 24, 2016: Journal of Pineal Research
https://www.readbyqxmd.com/read/27550416/modulation-of-il-6-induced-rankl-expression-in-arthritic-synovium-by-a-transcription-factor-sox5
#16
Xiaoke Feng, Yumeng Shi, Lingxiao Xu, Qiuyue Peng, Fang Wang, Xiaoxi Wang, Wei Sun, Yan Lu, Betty P Tsao, Miaojia Zhang, Wenfeng Tan
Receptor activator of nuclear factor κB ligand (RANKL) is critically involved in bone erosion of rheumatoid arthritis (RA). We previously reported association between younger age at onset of RA and a RANKL promoter SNP that conferred an elevated promoter activity via binding to a transcription factor SOX5. Here we study the regulation of SOX5 levels in relation to RANKL expression in RA synovial fibroblasts (SF) and the development of bone erosion in the collagen-induced arthritis (CIA) mouse. Our data indicated SOX5 levels were higher in synovium and synovial fluid from RA compared to osteoarthritis patients...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27549792/small-intestinal-injury-in-nsaid-users-suffering-from-rheumatoid-arthritis-or-osteoarthritis
#17
Ilja Tachecí, Petr Bradna, Tomáš Douda, Drahomíra Baštecká, Marcela Kopáčová, Stanislav Rejchrt, Martin Lutonský, Tomáš Soukup, Jan Bureš
: The goal of this prospective study was to assess non-steroidal anti-inflammatory drug (NSAID)-induced enteropathy in patients with rheumatoid arthritis (RA) or osteoarthritis (OA) by means of non-invasive wireless capsule enteroscopy. A total of 143 patients (74 with RA, 69 with OA) treated with NSAIDs (>1 month) and 42 healthy volunteers were included. All subjects underwent capsule endoscopy, laboratory tests and filled in questionnaires. The severity of small bowel injury was graded as: mild (red spots or sporadic erosions), moderate (10-20 erosions) or severe (>20 erosions or ulcers)...
November 2016: Rheumatology International
https://www.readbyqxmd.com/read/27545049/risk-factors-for-glenoid-erosion-in-patients-with-shoulder-hemiarthroplasty-an-analysis-of-118-cases
#18
Ramin Herschel, Karl Wieser, Mark E Morrey, Carlos H Ramos, Christian Gerber, Dominik C Meyer
BACKGROUND: Glenoid erosion is one of the main concerns in shoulder hemiarthroplasty. The goal of this study was to quantify glenoid erosion and to identify risk factors in patients with humeral hemiarthroplasty. METHODS: There were 118 shoulders in 113 patients available for a standardized retrospective review. Erosion was graded as follows: grade 1, none; grade 2, mild (erosion into subchondral bone); grade 3, moderate (medialization of subchondral bone with hemispheric deformation); or grade 4, severe...
August 18, 2016: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/27426968/intra-articular-basic-calcium-phosphate-and-monosodium-urate-crystals-inhibit-anti-osteoclastogenic-cytokine-signalling
#19
Clare C Cunningham, Emma M Corr, Geraldine M McCarthy, Aisling Dunne
OBJECTIVE: Basic calcium phosphate (BCP) and monosodium urate (MSU) crystals are particulates with potent pro-inflammatory effects, associated with osteoarthritis (OA) and gout, respectively. Bone erosion, due to increased osteoclastogenesis, is a hallmark of both arthropathies and results in severe joint destruction. The aim of this study was to investigate the effect of these endogenous particulates on anti-osteoclastogenic cytokine signalling. METHODS: Human osteoclast precursors were treated with BCP and MSU crystals prior to stimulation with IL-6 or IFN-γ and the effect on STAT-3 and STAT-1 activation in addition to MAP kinase activation was examined by immunoblotting...
July 14, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27371342/association-of-col1a1-polymorphism-with-subchondral-bone-degeneration-of-the-temporomandibular-joint
#20
S Luo, X Long, M Deng, Q Meng, J Ke, H Guo
The G/T polymorphism of the COL1A1 gene exhibits a clinically significant influence on bone remodelling, leading to a predisposition to degenerative diseases. The enhancement of bone turnover and further loss of bone mass are thought to be the primary pathological changes in the early degenerative course of temporomandibular joint osteoarthritis (TMJ OA), with the appearance of low-density lesions. Thus, it was hypothesized that this polymorphism may also affect this type of bone lesion in TMJ OA. A total of 130 TMJ OA patients with low-density lesions (cortical bone erosion, condylar head resorption, cyst-like lesion) and 186 healthy individuals were recruited...
June 28, 2016: International Journal of Oral and Maxillofacial Surgery
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