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Erosive Osteoarthritis

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https://www.readbyqxmd.com/read/28912428/il-37-is-associated-with-osteoarthritis-disease-activity-and-suppresses-proinflammatory-cytokines-production-in-synovial-cells
#1
Liping Ding, Xiaoping Hong, Baodong Sun, Qin Huang, Xiaoqi Wang, Xiaokai Liu, Lingyun Li, Zhong Huang, Dongzhou Liu
The objective of this study is to investigate the correlation between IL-37 level and osteoarthritis activity and to determine the anti-inflammatory effects of IL-37 in peripheral blood mononuclear cells (PBMCs) and synovial cells (SCs) from osteoarthritis (OA) patients, which including 32 patients with erosive inflammatory OA (EIOA) and 40 patients with primary generalized OA (PGOA), 40 age and sex matched healthy volunteers were recruited as healthy controls (HCs). The protein and relative mRNA levels of IL-37 were significant increased in the blood of EIOA patients compared with those of PGOA patients and HCs...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28875826/current-treatment-options-for-osteoarthritis
#2
Sevdalina Lambova, Walter Hermann, Ulf Müller-Ladner
BACKGROUND: Osteoarthritis (ОА) is the most common joint disease and a leading cause for impaired function and disability with significant treatment costs and socio-economic burden. Despite recent achievements in the knowledge on disease pathogenesis, the treatment is still a challenge and contrary to inflammatory joint diseases, no disease-modifying drugs are currently available for OA. OBJECTIVE: Different response in different localizations of the disease further complicates the therapeutic choice...
August 29, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28873346/painful-posterior-shoulder-instability-anticipating-and-preventing-failure-a-study-in-25-patients
#3
Jerome Garret, Geoffroy Nourissat, Marie Béatrice Hardy, Diego Antonucci, Philippe Clavert, Pierre Mansat, Arnaud Godenèche
BACKGROUND: Painful posterior shoulder instability (PPSI) is the least common of the three clinical patterns of posterior shoulder instability. PPSI is defined as pain combined with anatomical evidence of posterior instability but no instability events. MATERIAL AND METHOD: We studied a multicentre cohort of 25 patients with PPSI; 23 were identified retrospectively and had a follow-up of at least 2 years and 2 patients were included prospectively. Most patients engaged in sports...
September 2, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28865213/injection-in-temporomandibular-joint-of-rats-description-of-technical-protocol
#4
R Fuentes, C Veuthey, A Arias, D Saravia, N E Ottone
The development of animal models for research has been very diffused. Osteoarthritis is a joint degenerative pathology that induces cartilage erosion, chondrocyte proliferation and osteophyte formation. The aim of this paper is to present a technical procedure to perform the injection of monosodium iodine acetate in the temporomandibular joints of rats to generate osteoarthritis and to contribute to future research analysis related to pathology progression and proper treatment performance. The use of rat models may be a complex process because of their size, but they can be compared to the human temporomandibular joint due to the similar characteristics and the possibility of performing diagnosis and treatment protocols in order to detect this pathology...
March 1, 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/28816285/-expression-of-cxcl16-cxcr6-in-fibroblast-like-synoviocytes-in-rheumatoid-arthritis-and-its-role-in-synoviocyte-proliferation
#5
X Zhang, J X Zhao, L Sun, X Y Liu
OBJECTIVE: It has been found that serum CXCL16 concentration in rheumatoid arthritis (RA) patients are significantly higher than those in osteoarthritis (OA) and normal subjects, and are positively correlated with disease activity and bone erosion. However, how is CXCL16 involved in the pathogenesis of RA is unclear. To evaluate the expression of CXCL16 and its receptor CXCR6 in fibroblast-like synoviocytes (FLS) of rheumatoid arthritis (RA) patients, and to explore the role of CXCL16 in the proliferation of RA-FLS...
August 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28776109/clinical-and-radiological-results-7%C3%A2-years-after-copeland-shoulder-resurfacing-arthroplasty-in-patients-with-primary-glenohumeral-osteoarthritis-an-independent-multicentre-retrospective-study
#6
F U Verstraelen, L A Horta, M G M Schotanus, N P Kort, S K Samijo, E J P Jansen
PURPOSE: The aim of this multicentre cohort study was to evaluate the midterm outcomes and survival after cementless stemless resurfacing arthroplasty (CSRA) in a series of 33 shoulders in 27 patients with primary osteoarthritis. METHODS: Clinical outcome assessment included: Constant-Murley score (CMS); Simple Shoulder Test (SST); Disability of Arm, Shoulder, Hand (DASH); EuroQol-5D (EQ-5D) utility scores; Numerous Rating Scale (NRS) for pain. Radiographs were assessed by two independent observers for oversizing, radiolucency, glenohumeral subluxation, glenoid erosion and subsidence...
August 3, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28774457/conventional-radiology-in-crystal-arthritis-gout-calcium-pyrophosphate-deposition-and-basic-calcium-phosphate-crystals
#7
REVIEW
Thibaut Jacques, Paul Michelin, Sammy Badr, Michelangelo Nasuto, Guillaume Lefebvre, Neal Larkman, Anne Cotten
This article reviews the main radiographic features of crystal deposition diseases. Gout is linked to monosodium urate crystals. Classic radiographic features include subcutaneous tophi, large and well-circumscribed paraarticular bone erosions, and exuberant bone hyperostosis. Calcium pyrophosphate deposition (CPPD) can involve numerous structures, such as hyaline cartilages, fibrocartilages, or tendons. CPPD arthropathy involves joints usually spared by osteoarthritis. Basic calcium phosphate deposits are periarticular or intraarticular...
September 2017: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/28752579/osteoarthritic-human-chondrocytes-proliferate-in-3d-co-culture-with-mesenchymal-stem-cells-in-suspension-bioreactors
#8
Madiha Khurshid, Aillette Mulet-Sierra, Adetola Adesida, Arindom Sen
Osteoarthritis (OA) is a painful disease, characterized by progressive surface erosion of articular cartilage. The use of human articular chondrocytes (hACs) sourced from OA patients has been proposed as a potential therapy for cartilage repair, but this approach is limited by the lack of scalable methods to produce clinically relevant quantities of cartilage-generating cells. Previous studies in static culture have shown that hACs co-cultured with human mesenchymal stem cells (hMSCs) as 3D pellets can upregulate proliferation and generate neocartilage with enhanced functional matrix formation relative to that produced from either cell type alone...
July 28, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28752488/wnt-%C3%AE-catenin-signaling-in-osteoarthritis-and-in-other-forms-of-arthritis
#9
REVIEW
Yachuan Zhou, Tingyu Wang, John L Hamilton, Di Chen
PURPOSE OF REVIEW: Arthritis defines a large group of diseases primarily affecting the joint. It is the leading cause of pain and disability in adults. Osteoarthritis (OA) affecting the knee or hip is the most common form among over 100 types of arthritis. Other types of arthritis include erosive hand OA, temporomandibular joint (TMJ) OA, facet joint OA, diffuse idiopathic skeletal hyperostosis (DISH), and spondyloarthritis (SpA). However, the specific molecular signals involved in the development and progression of OA and related forms of arthritis remain largely unknown...
September 2017: Current Rheumatology Reports
https://www.readbyqxmd.com/read/28743830/role-of-melatonin-combined-with-exercise-as-a-switch-like-regulator-for-circadian-behavior-in-advanced-osteoarthritic-knee
#10
Yunkyung Hong, Hyunsoo Kim, Seunghoon Lee, Yunho Jin, Jeonghyun Choi, Sang-Rae Lee, Kyu-Tae Chang, Yonggeun Hong
Here, we show the role of melatonin combined with or without exercise as a determinant of multicellular behavior in osteoarthritis. We address the relationship between the molecular components governing local circadian clock and changes in the osteoarthritic musculoskeletal axis. Melatonin was injected subcutaneously in animals with advanced knee osteoarthritis (OA) for 4 weeks. Concurrently, moderate treadmill exercise was applied for 30 min/day. Morphometric, histological, and gene/protein-level analyses were performed in the cartilage, synovium, bone, and gastrocnemius muscle...
July 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28732700/evaluation-of-trabecular-structure-changes-in-osteoarthritis-of-the-temporomandibular-joint-with-cone-beam-computed-tomography-imaging
#11
Xin Liang, Shuming Liu, Xingmin Qu, Zhihui Wang, Jianbo Zheng, Xiaoyan Xie, Guowu Ma, Zuyan Zhang, Xuchen Ma
OBJECTIVES: To explore the possibility of using 2-dimensional image assessments in combination with cone beam computed tomography (CBCT) in patients with temporomandibular joint osteoarthritis (TMJOA) to enhance the clinical significance and applicability of the CBCT findings on TMJOA changes. STUDY DESIGN: Fifty-two patients with unilateral TMJOA and 40 healthy adults who had undergone CBCT in preparation for orthodontic treatment were selected for this study. Temporomandibular joint images were acquired with CBCT...
June 8, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28729639/stimulation-of-osteoclast-migration-and-bone-resorption-by-c-c-chemokine-ligands-19-and-21
#12
Jiyeon Lee, Cheolkyu Park, Hyung Joon Kim, Yong Deok Lee, Zang Hee Lee, Yeong Wook Song, Hong-Hee Kim
Osteoclasts are responsible for the bone erosion associated with rheumatoid arthritis (RA). The upregulation of the chemokines CCL19 and CCL21 and their receptor CCR7 has been linked to RA pathogenesis. The purpose of this study was to evaluate the effects of CCL19 and CCL21 on osteoclasts and to reveal their underlying mechanisms. The expression of CCL19, CCL21 and CCR7 was higher in RA patients than in osteoarthritis patients. In differentiating osteoclasts, tumor necrosis factor-α, interleukin-1β and lipopolysaccharide stimulated CCR7 expression...
July 21, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/28711879/the-prevalence-incidence-and-progression-of-hand-osteoarthritis-in-relation-to-body-mass-index-smoking-and-alcohol-consumption
#13
Ida K Haugen, Karin Magnusson, Aleksandra Turkiewicz, Martin Englund
OBJECTIVE: To estimate the extent that overweight/obesity, smoking, and alcohol are associated with prevalence and longitudinal changes of radiographic hand osteoarthritis (OA). METHODS: Participants from the Osteoarthritis Initiative (n = 1232) were included, of whom 994 had 4-year followup data. In analyses on incident hand OA, only persons without hand OA at baseline were included (n = 406). Our exposure variables were overweight/obesity [body mass index (BMI), waist circumference], smoking (current/former, smoking pack-yrs), and alcohol consumption (drinks/week)...
July 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28699681/occurrence-of-signs-of-osteoarthritis-arthrosis-in-the-temporomandibular-joint-on-panoramic-radiographs-in-swedish-women
#14
Karin Bäck, Margareta Ahlqwist, Magnus Hakeberg, Lars Dahlström
OBJECTIVES: To determine the prevalence and incidence of radiographic signs of osteoarthritis/osteoarthrosis (OA) in the temporomandibular joint (TMJ) among middle-aged and older women. METHODS: Data were collected from ongoing representative, longitudinal and repeated cross-sectional studies in Gothenburg, Sweden. Panoramic radiographs (PAN) have been taken regularly since 1968. The cohorts were systematically selected from the female population at the ages of 38, 50, 62 and 74...
July 12, 2017: Community Dentistry and Oral Epidemiology
https://www.readbyqxmd.com/read/28680846/effectiveness-of-digital-subtraction-radiography-in-detecting-artificially-created-osteophytes-and-erosions-in-the-temporomandibular-joint
#15
Husniye Demirturk Kocasarac, Peruze Celenk
PURPOSE: Erosions and osteophytes are radiographic characteristics that are found in different stages of temporomandibular joint (TMJ) osteoarthritis. This study assessed the effectiveness of digital subtraction radiography (DSR) in diagnosing simulated osteophytes and erosions in the TMJ. MATERIALS AND METHODS: Five intact, dry human skulls were used to assess the effectiveness of DSR in detecting osteophytes. Four cortical bone chips of varying thicknesses (0...
June 2017: Imaging Science in Dentistry
https://www.readbyqxmd.com/read/28666239/cryptotanshinone-protects-against-il-1%C3%AE-induced-inflammation-in-human-osteoarthritis-chondrocytes-and-ameliorates-the-progression-of-osteoarthritis-in-mice
#16
Zhenhua Feng, Wenhao Zheng, Xiaobin Li, Jian Lin, Chenglong Xie, Hang Li, Liang Cheng, Aimin Wu, Wenfei Ni
Osteoarthritis (OA) is a common degenerative disease characterized by progressive erosion of articular cartilage, subchondral bone sclerosis and synovitis. Cryptotanshinone (CTS), an active component extracted from the root of Salvia miltiorrhiza Bunge, has been shown to have potent anti-inflammatory effects. However, its effects on OA have not been clearly elucidated. This study aimed to assess the effect of CTS on human OA chondrocytes and mice OA models. Human OA chondrocytes were pretreated with CTS (5, 10 and 20μM) for 2h and subsequently stimulated with IL-1β for 24h...
June 27, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28659793/revisiting-the-role-of-interleukin-1-pathway-in-osteoarthritis-interleukin-1%C3%AE-and-1%C3%AE-and-nlrp3-inflammasome-are-not-involved-in-the-pathological-features-of-the-murine-menisectomy-model-of-osteoarthritis
#17
Sonia Nasi, Hang-Korng Ea, Alexander So, Nathalie Busso
Background: Innate immune response components such as toll-like receptors (TLRs) and NLRP3-inflammasome act in concert to increase IL-1α/β secretion by synovial macrophages. Previous results suggest that IL-1α/β could be an important mediator involved in the pathogenesis of osteoarthritis (OA). Objectives: The aim of our study was to evaluate the role of NLRP3, IL-1β, and IL-1α in the menisectomy (MNX) model of murine OA. Methods: Murine chondrocytes (CHs) and bone marrow-derived machrophages (BMDM) were stimulated with hydroxyapatite (HA) crystals, a form of calcium-containing crystal found in human OA, and IL-1β and IL-6 secretion assayed by ELISA...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28640163/mistletoe-fig-ficus-deltoidea-jack-leaf-extract-prevented-postmenopausal-osteoarthritis-by-attenuating-inflammation-and-cartilage-degradation-in-rat-model
#18
Nur Adeelah Che Ahmad Tantowi, Paisal Hussin, Seng Fong Lau, Suhaila Mohamed
OBJECTIVE: Ficus deltoidea Jack (mistletoe fig) is an ornamental plant found in various parts of the world and used as traditional herbal medicine in some countries. This study investigated the potential use of F deltoidea leaf extract to mitigate osteoarthritis (OA) in ovariectomized (estrogen-deficient postmenopausal model) rats and the mechanisms involved. Diclofenac was used for comparison. METHODS: Sprague-Dawley female rats (12 weeks old) were divided randomly into five groups (n = 6): healthy; nontreated OA; OA + diclofenac (5 mg/kg); OA + extract (200 mg/kg); and OA + extract (400 mg/kg)...
September 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28589079/role-of-light-in-the-pathogenesis-of-joint-destruction-in-rheumatoid-arthritis
#19
Afsie Sabokbar, Sara Afrough, David J Mahoney, Yoshinobu Uchihara, Catherine Swales, Nicholas A Athanasou
AIM: To characterise the role of substitutes for receptor-activator nuclear factor kappa-B ligand (RANKL) in rheumatoid arthritis (RA) joint destruction. METHODS: Synovial fluid (SF) macrophages isolated from the knee joint of RA patients were incubated with 25 ng/mL macrophage-colony stimulating factor (M-CSF) and 50 ng/mL LIGHT (lymphotoxin-like, exhibits inducible expression and competes with herpes simplex virus glycoprotein D for herpes virus entry mediator, a receptor expressed by T lymphocytes) in the presence and absence of 25 ng/mL RANKL and 100 ng/mL osteoprotegerin (OPG) on glass coverslips and dentine slices...
May 20, 2017: World Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28585236/melatonin-in-regulation-of-inflammatory-pathways-in-rheumatoid-arthritis-and-osteoarthritis-involvement-of-circadian-clock-genes
#20
REVIEW
Rana Jahanban-Esfahlan, Saeed Mehrzadi, Russel J Reiter, Khaled Seidi, Maryam Majidinia, Hossein Bannazadeh Baghi, Nasrin Khatami, Bahman Yousefi, Alireza Sadeghpour
Rheumatoid arthritis (RA) and osteoarthritis (OA) are the two most prevalent joint diseases; they are important causes of pain and disability in a substantial proportion of the human population. A common characteristic of these diseases is the erosion of articular cartilage and consequently joint dysfunction. Melatonin (MLT) is proposed as a potential link between the circadian rhythms and joint diseases including RA and OA. This agent elicits divergent regulatory actions through binding to specific receptors and intracellular targets as well as having receptor-independent actions as a free radical scavenger...
June 5, 2017: British Journal of Pharmacology
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