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Erosive Osteoarthritis

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https://www.readbyqxmd.com/read/28090062/ankylosis-of-the-finger-in-erosive-osteoarthritis
#1
Naoho Takizawa, Takuya Hamada, Yoshiro Fujita
No abstract text is available yet for this article.
2017: Internal Medicine
https://www.readbyqxmd.com/read/28089255/characterization-of-the-walch-b3-glenoid-in-primary-osteoarthritis
#2
Kevin Chan, Nikolas K Knowles, Jean Chaoui, Marc-Olivier Gauci, Louis M Ferreira, Gilles Walch, George S Athwal
BACKGROUND: The type B3 glenoid is an addition to the Walch classification. A potential etiologic theory is that it is a progression of the B2. It is characterized by uniconcavity, absent paleoglenoid, medialization, retroversion, and subluxation. The purpose of this study was to describe the morphology of B3 glenoids. METHODS: Fifty-two patients with B3 glenoids underwent 3-dimensional analysis of computed tomography data. Glenoid measurements (retroversion, inclination, medialization) and humeral head subluxation according to the scapular and glenoid planes were determined...
January 11, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28054155/radiological-and-histological-analysis-of-two-replaced-interphalangeal-joints-with-active-subchondral-bone-resorption-in-erosive-hand-osteoarthritis-a-novel-mechanism
#3
Marta Favero, Giorgio Perino, Maria Luisa Valente, Cesare Tiengo, Roberta Ramonda
The aim of this study was to describe the histological features of erosive hand osteoarthritis (EHOA), which is considered an aggressive subset of hand osteoarthritis (OA) characterized by severe local inflammation and degeneration of the distal and proximal interphalangeal joints. Two patients with EHOA underwent replacement with a cement-free press fit ceramic prosthesis of a proximal interphalangeal joint (PIPJ). Clinical and radiological data were collected and histological examination was performed. Radiological examination with histological correlation showed complete erosion of the articular cartilage with focal presence of peripheral fibrocartilaginous resurfacing, sclerosis, and remodeling of the exposed bone, osteoclastic activity with resorptive lacunae in the subchondral bone and around degenerative fibromyxoid pseudocysts, coarse trabeculation of the cancellous bone, and marginal osteophytes...
January 4, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/27965260/ccl2-ccr2-but-not-ccl5-ccr5-mediates-monocyte-recruitment-inflammation-and-cartilage-destruction-in-osteoarthritis
#4
Harini Raghu, Christin M Lepus, Qian Wang, Heidi H Wong, Nithya Lingampalli, Francesca Oliviero, Leonardo Punzi, Nicholas J Giori, Stuart B Goodman, Constance R Chu, Jeremy B Sokolove, William H Robinson
OBJECTIVES: While various monocyte chemokine systems are increased in expression in osteoarthritis (OA), the hierarchy of chemokines and chemokine receptors in mediating monocyte/macrophage recruitment to the OA joint remains poorly defined. Here, we investigated the relative contributions of the CCL2/CCR2 versus CCL5/CCR5 chemokine axes in OA pathogenesis. METHODS: Ccl2-, Ccr2-, Ccl5- and Ccr5-deficient and control mice were subjected to destabilisation of medial meniscus surgery to induce OA...
December 13, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27940594/the-comparison-of-magnetic-resonance-imaging-and-radiographs-to-assess-structural-progression-over-5-years-in-hand-osteoarthritis
#5
Ida Kristin Haugen, Barbara Slatkowsky-Christensen, Karwan Faraj, Désirée van der Heijde, Tore Kristian Kvien
OBJECTIVE: The aim was to explore the agreement between 1.0 T MRI and conventional radiography (CR) to detect progression of hand OA over 5 years and the associations between structural progression and incident joint tenderness. METHODS: Paired radiographs and paired MRIs of the second-fifth IP joints of the dominant hand from 69 hand OA patients were read for osteophytes, joint space narrowing and erosions. Patients with two or more joints demonstrating progression of any structural feature(s) were classified as progressors per imaging modality...
December 10, 2016: Rheumatology
https://www.readbyqxmd.com/read/27928662/predictors-of-medium-term-clinical-outcomes-after-total-shoulder-arthroplasty
#6
Tim Leschinger, Patric Raiss, Markus Loew, Felix Zeifang
PURPOSE: The study aims to measure the relationship of potential clinical and radiographic predictors and medium-term clinical outcomes after total shoulder arthroplasty in primary osteoarthritis. MATERIALS AND METHODS: In a prospective follow-up study, preoperatively collected clinical and radiographic variables were recorded in 103 patients with an average age of 66 years (range 37-83 years) to measure their influence on the clinical outcome by use of the Constant score...
December 7, 2016: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/27917634/-hand-osteoarthritis
#7
Ladislav Šenolt
Hand osteoarthritis (OA) is a common chronic disorder causing pain and limitation of mobility of affected joints. The prevalence of hand OA increases with age and more often affects females. Clinical signs obviously do not correlate with radiographic findings - symptomatic hand OA affects approximately 26 % of adult subjects, but radiographic changes can be found in up to two thirds of females and half of males older than 55 years.Disease course differ among individual patients. Hand OA is a heterogeneous disease...
2016: Casopís Lékar̆ů C̆eských
https://www.readbyqxmd.com/read/27863298/butein-inhibits-il-1%C3%AE-induced-inflammatory-response-in-human-osteoarthritis-chondrocytes-and-slows-the-progression-of-osteoarthritis-in-mice
#8
Wenhao Zheng, Hui Zhang, Yonglong Jin, Quan Wang, Linwei Chen, Zhenhua Feng, Hua Chen, Yaosen Wu
Osteoarthritis (OA) is a progressive degenerative disease characterized by irreversible articular cartilage destruction. Butein, a polyphenolic compound isolated from the stem bark of cashews and Rhus verniciflua Stokes, has been reported to have anti-inflammatory effects. This study aimed to assess the effect of butein on human OA chondrocytes and mice OA models induced by destabilization of the medial meniscus (DMM). In vitro, human OA chondrocytes were pretreated with butein at 10, 50μM and subsequently stimulated with IL-1β (10ng/ml) for 24h...
January 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/27851983/osteopontin-inhibition-of-mir-129-3p-enhances-il-17-expression-and-monocyte-migration-in-rheumatoid-arthritis
#9
Chun-Hao Tsai, Shan-Chi Liu, Yu-Han Wang, Chen-Ming Su, Chien-Chung Huang, Chin-Jung Hsu, Chih-Hsin Tang
BACKGROUND: Osteopontin (OPN) is an important proinflammatory cytokine in rheumatoid arthritis (RA). Levels of OPN have been shown to be significantly correlated with interleukin-17 (IL-17) production and expression of Th17 cells in the synovial fluid of RA patients. Here, we investigated the role of OPN in monocyte migration, IL-17 production and osteoblasts. METHODS: OPN and IL-17 expression profiles in osteoarthritis (OA) and RA synovial fluid were determined by enzyme-linked immunosorbent assay (ELISA)...
February 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27847665/an-unusual-and-complicated-course-of-a-giant-cell-tumor-of-the-capitate-bone
#10
Ingo Schmidt
A 51-year-old female patient presented with a carpal giant cell tumor (GCT) of the right capitate bone. The lesion was initially misdiagnosed as having an osteomyelitis. First, the diagnosis of a benign GCT was confirmed by histological examination. Second, an intralesional curettage and packing of the cavity with cancellous iliac crest bone grafts combined with a fusion of the third carpometacarpal (CMC III) joint were carried out. Third, due to a secondary midcarpal osteoarthritis and a secondary scaphoid nonunion, the CMC III joint fusion plate was removed and the midcarpal joint completely excised...
2016: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/27820852/osteoarthritis-in-the-knee-joints-of-g%C3%A3-ttingen-minipigs-after-resection-of-the-anterior-cruciate-ligament-missing-correlation-of-mri-gene-and-protein-expression-with-histological-scoring
#11
Gregor Reisig, Michael Kreinest, Wiltrud Richter, Mechthild Wagner-Ecker, Dietmar Dinter, Ulrike Attenberger, Barbara Schneider-Wald, Stefan Fickert, Markus L Schwarz
INTRODUCTION: The Göttingen Minipig (GM) is used as large animal model in articular cartilage research. The aim of the study was to introduce osteoarthritis (OA) in the GM by resecting the anterior cruciate ligament (ACLR) according to Pond and Nuki, verified by histological and magnetic resonance imaging (MRI) scoring as well as analysis of gene and protein expression. MATERIALS AND METHODS: The eight included skeletally mature female GM were assessed after ACLR in the left and a sham operation in the right knee, which served as control...
2016: PloS One
https://www.readbyqxmd.com/read/27749237/mri-and-serum-biomarkers-correlate-with-radiographic-features-in-painful-hand-osteoarthritis
#12
Christian H Roux, Violaine Foltz, Emmanuel Maheu, Gabriel Baron, Frederique Gandjbakhch, Cédric Lukas, Daniel Wendling, Damien Loeuille, Pierre Lafforgue, Liana Euler-Ziegler, Pascal Richette, Xavier Chevalier
OBJECTIVES: To explore the relationship between clinical findings, biologic biomarkers, conventional radiography and MRI in patients with painful hand OA. METHODS: The following patient baseline data from the DORA study (evaluating anti-TNF-α agents against painful hand OA) were used: clinical assessment (pain, swelling, stiffness and function: Dreiser functional hand index [FIHOA] and Cochin hand functional scale [CHFS]); measurement of biomarkers (cartilage oligomeric matrix protein (COMP), type IIA collagen N-propeptid (PIINP), hyaluronic acid (HA), ultrasensitive C-reactive protein (usCRP), tumour necrosis factor (TNF), interleukin (IL)-6, IL-1β and urinary CTXII); radiological staging (Verbruggen, Kallman, Kellgren-Lawrence); anatomical evaluation by contrast-enhanced MRI of proximal and distal interphalangeal joints of dominant hand...
November 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27698783/increased-receptor-activator-of-nuclear-factor-%C3%AE%C2%BA%C3%AE-ligand-osteoprotegerin-ratio-exacerbates-cartilage-destruction-in-osteoarthritis-in-vitro
#13
Ji-Zhou Zeng, Zhen-Zhong Wang, Li-Feng Ma, Hai Meng, Hao-Miao Yu, Wen-Hao Cheng, Ya-Kui Zhang, Ai Guo
Osteoarthritis (OA) is a degenerative joint disease characterized by progressive cartilage destruction, matrix degradation and bony changes. Subchondral bone alterations in osteoarthritis are associated with cartilage destruction. It has previously been demonstrated that osteoprotegerin (OPG) and receptor activator of nuclear factor κβ ligand (RANKL) mediate this process. The RANKL/OPG ratio is altered in OA chondrocytes compared with normal chondrocytes. In the pathogenesis of OA, abnormal expression levels of matrix metalloproteinase-13 (MMP-13) are secreted by chondrocytes has a vital role in the progression of cartilage erosion...
October 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27692966/erosive-osteoarthritis-a-systematic-analysis-of-definitions-used-in-the-literature
#14
David J Gazeley, Supraja Yeturi, Payal J Patel, Ann K Rosenthal
BACKGROUND: Erosive osteoarthritis (EOA) is a commonly invoked diagnosis representing an important variant of hand osteoarthritis (OA). There is increasing literature on the prevalence, risk factors, etiology, and management of EOA. METHODS: We systematically reviewed the literature to assess variability in the diagnostic definitions used to define EOA in these studies. RESULTS: We reviewed 336 articles and found 62 articles citing diagnostic definitions for EOA...
August 24, 2016: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/27668577/efficacy-of-intravenous-administration-of-hyaluronan-sodium-chondroitin-sulfate-and-n-acetyl-d-glucosamine-for-prevention-or-treatment-of-osteoarthritis-in-horses
#15
RANDOMIZED CONTROLLED TRIAL
David D Frisbie, C Wayne McIlwraith, Christopher E Kawcak, Natasha M Werpy
OBJECTIVE To evaluate the efficacy of IV administration of a product containing hyaluronan, sodium chondroitin sulfate, and N-acetyl-d-glucosamine for prevention or treatment of osteoarthritis in horses. ANIMALS 32 healthy 2- to 5-year-old horses. PROCEDURES The study involved 2 portions. To evaluate prophylactic efficacy of the test product, horses received 5 mL of the product (n = 8) or saline (0.9% NaCl) solution (8; placebo) IV every fifth day, starting on day 0 (when osteoarthritis was induced in the middle carpal joint of 1 forelimb) and ending on day 70...
October 2016: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/27666624/single-source-dual-energy-computed-tomography-in-the-diagnosis-of-gout-diagnostic-reliability-in-comparison-to-digital-radiography-and-conventional-computed-tomography-of-the-feet
#16
COMPARATIVE STUDY
Tobias Kiefer, Torsten Diekhoff, Sandra Hermann, Andrea Stroux, Jürgen Mews, Jörg Blobel, Bernd Hamm, Kay-Geert A Hermann
OBJECTIVES: To investigate the diagnostic value of single-source dual-energy computed tomography (SDECT) in gouty arthritis and to compare its capability to detect urate depositions with digital radiography (DR) and conventional computed tomography (CT). METHODS: Forty-four patients who underwent SDECT volume scans of the feet for suspected gouty arthritis were retrospectively analyzed. SDECT, CT (both n=44) and DR (n=36) were scored by three blinded readers for presence of osteoarthritis, erosions, and tophi...
October 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27664978/early-focal-changes-in-cartilage-cellularity-and-structure-following-surgically-induced-meniscal-destabilization-in-the-mouse
#17
Michael A David, Melanie K Smith, Rachael N Pilachowski, Avery T White, Ryan C Locke, Christopher Price
Post-traumatic osteoarthritis (PTOA) is an accelerated form of osteoarthritic cartilage degeneration affecting approximately 20-50% of patients experiencing joint injury. Currently PTOA is incurable; to better understand the etiology of PTOA and to develop rational anti-osteoarthritic therapies, it is critical to understand the spatiotemporal initiation and the progression of PTOA. In this study, we employed semi-quantitative histological scoring and quantitative damage analysis to examine disease progression in the murine destabilization of the medial meniscus (DMM) model of PTOA from early (3 days) through late- (112 days) disease timepoints...
September 24, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/27658905/efficacy-of-intra-articular-corticosteroid-injection-in-erosive-hand-osteoarthritis-infrared-thermal-imaging
#18
Marta Favero, Roberta Ramonda, Marco Rossato
No abstract text is available yet for this article.
January 2017: Rheumatology
https://www.readbyqxmd.com/read/27658487/cellular-senescence-in-aging-and-osteoarthritis
#19
Wei Seong Toh, Mats Brittberg, Jack Farr, Casper Bindzus Foldager, Andreas H Gomoll, James Hoi Po Hui, James B Richardson, Sally Roberts, Myron Spector
- It is well accepted that age is an important contributing factor to poor cartilage repair following injury, and to the development of osteoarthritis. Cellular senescence, the loss of the ability of cells to divide, has been noted as the major factor contributing to age-related changes in cartilage homeostasis, function, and response to injury. The underlying mechanisms of cellular senescence, while not fully understood, have been associated with telomere erosion, DNA damage, oxidative stress, and inflammation...
September 23, 2016: Acta Orthopaedica
https://www.readbyqxmd.com/read/27632984/synovial-inflammation-drives-structural-damage-in-hand-osteoarthritis-a-narrative-literature-review
#20
Luana Mancarella, Olga Addimanda, Carlotta Cavallari, Riccardo Meliconi
BACKGROUND: Ultrasound is one of the most promising candidates for detection of inflammation and structural damage in hand osteoarthritis. OBJECTIVE: To evaluate new advances of US as a diagnostic and prognostic tool in hand osteoarthritis assessment. METHODS: We conducted a Medline on PubMed search for articles about "ultrasonography" and "hand OA" published between January 2012 and 15th April 2016, limiting our search to articles on human adults in English, excluding those involving inflammatory diseases, visualization of joints other than hands, ultrasound guided injections and surgical procedures...
September 9, 2016: Current Rheumatology Reviews
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