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Erosive Osteoarthritis

Dawn Aitken, Laura L Laslett, Feng Pan, Ida K Haugen, Petr Otahal, Nicholas Bellamy, Paul Bird, Graeme Jones
OBJECTIVE: To assess the efficacy of adalimumab in patients with erosive hand osteoarthritis (OA). METHOD: Patients >50 years old, meeting the ACR criteria for hand OA, with pain >50 on 100mm VAS, morning stiffness >30 minutes and >1 erosive joint on x-ray with synovitis present on MRI were included in a randomised double-blind placebo-controlled crossover trial. Patients were randomised to adalimumab (40 mg subcutaneous injections every other week) or identical placebo injections for 12 weeks followed by an 8-week washout and then crossed over treatment groups for another 12 weeks...
February 27, 2018: Osteoarthritis and Cartilage
Iffah Nadhira Madzuki, Seng Fong Lau, Nur Adeelah Che Ahmad Tantowi, Nur Iliyani Mohd Ishak, Suhaila Mohamed
The tropical herb Labisia pumila is traditionally used in facilitating childbirth and post-partum care. The effects of L. pumila leaf extract (LP) in explant cartilage culture and on postmenopausal osteoarthritis (OA) rat model were assessed. The LP (10, 25 and 50 µg/ml) or diclofenac (10 µg/ml) was added to the cartilage explants containing bovine IL-1β (20 ng/ml), to evaluate their direct effects on cartilage degradation. In the preclinical study, rats were grouped (n = 8) into: non-treated OA; OA + diclofenac (5 mg/kg); OA + LP extract (150 and 300 mg/kg); and healthy control...
February 19, 2018: Inflammopharmacology
Chenglei Liu, Chang Liu, Liping Si, Hao Shen, Qian Wang, Weiwu Yao
BACKGROUND: The importance of subchondral bone in the pathogenesis of osteoarthritis (OA) has drawn interest. PURPOSE: To investigate subregional trabecular bone microstructural features and to determine the relationship between cartilage and trabecular bone in the osteoarthritic human knee. STUDY TYPE: Prospective study. SUBJECTS: In all, 92 knees were enrolled and divided into three groups: without OA, mild OA, and severe OA...
February 16, 2018: Journal of Magnetic Resonance Imaging: JMRI
Jie Qian, Lingxiao Xu, Xiaoxuan Sun, Yani Wang, Wenhua Xuan, Qian Zhang, Pengfei Zhao, Qin Wu, Rui Liu, Nan Che, Fang Wang, Wenfeng Tan, Miaojia Zhang
BACKGROUND: We have previously reported that adiponectin (AD), an adipokine that is secreted by adipocytes, correlates well with progressive bone erosion in rheumatoid arthritis (RA). The exact mechanism of AD in promoting joint destruction remains unclear. Osteopontin (OPN) is required for osteoclast recruitment. We hypothesized that AD exacerbates bone erosion by inducing OPN expression in synovial tissue. This study aimed to evaluate a novel role for AD in RA. METHODS: The serum levels of AD and OPN were determined in 38 patients with RA, 40 patients with osteoarthritis (OA), and 20 healthy controls using enzyme-linked immunosorbent assay (ELISA)...
February 8, 2018: Arthritis Research & Therapy
A Fioravanti, S Tenti, L Pulsatelli, O Addimanda
No abstract text is available yet for this article.
January 29, 2018: Scandinavian Journal of Rheumatology
Dharmendra Choudhary, Sulekha Adhikary, Naseer Ahmad, Priyanka Kothari, Ashwni Verma, Prabodh Kumar Trivedi, Prabhat Ranjan Mishra, Ritu Trivedi
Withaferin A (WFA), a highly oxygenated withanolide is used for anti-osteoporotic, fracture healing, obesity control as medicine and dietary supplement in Ayurveda and Unani medicine but its potential remains to be investigate for the osteoarthritis studies. In the present study, chondro-protective effects of WFA, under in vitro and in vivo conditions were evaluated. In-vitro pharmacological activity of WFA was tested on rat articular chondrocytes through MTT, DPPH, different staining, FACS and translation studies...
January 10, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Priyanka Sivakumaran, Sidra Hussain, Coziana Ciurtin
This is the first study to investigate the usefulness of a standardized ultrasound (US) examination protocol in diagnosing hand osteoarthritis (OA). We conducted a cross-sectional study including 62 patients, ultimately diagnosed with hand OA based on imaging evidence of osteoarthritic changes with the particular distribution required for fulfilment of American College of Radiology diagnosis criteria. We compared a 32-joint US score (wrists, metacarpophalangeal [MCP], proximal interphalangeal [PIP] or distal interphalangeal [DIP] and carpometacarpal [CMC]-1 joints), with smaller, predefined joint scores, assessing 22 joints (wrists, MCPs and PIPs or PIPs, DIPs and CMC-1), 10 joints (MCP 2-3, PIP 2-3 and CMC-1 or PIP 2-3, DIP 2-3 and CMC-1) and 6 joints (DIP 2-3, CMC-1), respectively...
March 2018: Ultrasound in Medicine & Biology
Adrian Weber, Pok Man Boris Chan, Chunyi Wen
Osteoarthritis (OA) is a whole-joint disorder, and non-cartilage articular pathologies, e.g. subchondral bone disturbance, contribute substantially to the onset and progression of the disease. In the early stage of OA, abnormal mechanical loading leads to micro-cracks or micro-fractures that trigger a reparative process with angiogenesis and inflammatory response. With the progression of disease, cystic lesion, sclerosis and osteophytosis occur at tissue level, and osteoblast dysfunction at cellular level. Osteoblasts derived from OA sclerotic bone produce increased amount of type I collagen with aberrant Col1A1/A2 ratio and poor mineralization capability...
December 22, 2017: Progress in Biophysics and Molecular Biology
Justin J Mitchell, Dimitri S Tahal, J Christoph Katthagen, Alexander R Vap, Peter J Millett
CASE: Hemiarthroplasty of the shoulder is commonly indicated for younger patients with osteoarthritis who desire to continue recreational and employment activities. In patients who have undergone prior shoulder surgery, metallic suture anchors may be present in the glenoid. We present a case of bilateral shoulder metallosis following bilateral resurfacing hemiarthroplasty for arthropathy in the setting of previous shoulder instability; the prostheses caused eventual glenoid erosion, leading to contact with the retained metal anchors...
April 2017: JBJS Case Connector
Yunkyung Hong, Hyunsoo Kim, Seunghoon Lee, Yunho Jin, Jeonghyun Choi, Sang-Rae Lee, Kyu-Tae Chang, Yonggeun Hong
Here, we show the role of melatonin combined with or without exercise as a determinant of multicellular behavior in osteoarthritis. We address the relationship between the molecular components governing local circadian clock and changes in the osteoarthritic musculoskeletal axis. Melatonin was injected subcutaneously in animals with advanced knee osteoarthritis (OA) for 4 weeks. Concurrently, moderate treadmill exercise was applied for 30 min/day. Morphometric, histological, and gene/protein-level analyses were performed in the cartilage, synovium, bone, and gastrocnemius muscle...
November 14, 2017: Oncotarget
Chenglei Liu, Chang Liu, Xvhua Ren, Liping Si, Hao Shen, Qian Wang, Weiwu Yao
BACKGROUND: Osteoarthritis (OA) is now increasingly recognized as being related to the whole joint instead of the cartilage alone. In particular, the importance of subchondral bone in OA pathogenesis has drawn a lot of interest. The aim of this study is to investigate subchondral bone microstructural features in two femoral condyles of human knee osteoarthritis. METHODS: Eighty subjects were enrolled in our study and divided into three groups: without OA (group 0), mild OA (group 1), and severe OA (group 2)...
November 28, 2017: BMC Musculoskeletal Disorders
Lihui Wen, Min-Ho Shin, Ji-Hyoun Kang, Yi-Rang Yim, Ji-Eun Kim, Jeong-Won Lee, Kyung-Eun Lee, Dong-Jin Park, Tae-Jong Kim, Yong-Wook Park, Sun-Seog Kweon, Young-Hoon Lee, Yong-Woon Yun, Shin-Seok Lee
Due to the inconsistent association between high-sensitivity C-reactive protein (hs-CRP) and osteoarthritis (OA), we evaluated the relationship between hs-CRP and various radiographic findings in older adults with OA. This cross-sectional study recruited 2376 participants from the population-based Dong-gu cohort. The scores of radiographic features in OA on X-rays of the knees and hands were computed using a semi-quantitative grading system. The hs-CRP levels were measured using a particle-enhanced immunonephelometry assay...
November 21, 2017: Clinical Rheumatology
L Xu, F Hu, H Zhu, X Liu, L Shi, Y Li, H Zhong, Y Su
The TAM receptor tyrosine kinases (TAM RTK) are a subfamily of receptor tyrosine kinases, the role of which in autoimmune diseases such as systemic lupus erythematosus has been well explored, while their functions in rheumatoid arthritis (RA) remain largely unknown. In this study, we investigated the role of soluble TAM receptor tyrosine kinases (sAxl/sMer/sTyro3) in patients with RA. A total of 306 RA patients, 100 osteoarthritis (OA) patients and 120 healthy controls (HCs) were enrolled into this study. The serum concentrations of sAxl/sMer/sTyro3 were measured by enzyme-linked immunosorbent assay (ELISA), then the associations between sAxl/sMer/sTyro3 levels and clinical features of RA patients were analysed...
April 2018: Clinical and Experimental Immunology
Xingchen Li, Yang Xu, Yuan Zhu, Xiangyang Xu
BACKGROUND: Diffused-type giant cell tumor(Dt-GCT) is a rare, aggressive disorder of the joint synovium, bursa and tendon sheaths. Osseous erosions and subchondral cysts may develop as the result of synovium infiltration in Dt-GCT. We present a retrospective study of a series of patients who are diagnosed with Dt-GCT about the ankle joint, there clinical outcome is evaluated in this study. MATERIAL AND METHOD: Fifteen patients with radiologically and histologically confirmed Dt-GCT about the ankle joint were identified in our foot and ankle department...
November 14, 2017: BMC Musculoskeletal Disorders
Ryan E Breighner, Yoshimi Endo, Gabrielle P Konin, Lawrence V Gulotta, Matthew F Koff, Hollis G Potter
Purpose To determine the intermodality agreement of morphologic grading and clinically relevant quantitative measurements between computed tomography (CT) and zero echo time (ZTE) magnetic resonance (MR) imaging of the shoulder. The primary objective was to demonstrate the clinical applicability of ZTE in osseous shoulder imaging. Materials and Methods Thirty-four patients undergoing standard-of-care (SOC) MR imaging with concomitant CT were enrolled in this institutional review board-approved study. ZTE images were acquired after SOC MR imaging...
November 8, 2017: Radiology
A Fioravanti, S Cheleschi, A De Palma, O Addimanda, L Mancarella, E Pignotti, L Pulsatelli, M Galeazzi, R Meliconi
PURPOSE: To evaluate serum levels of visfatin, resistin and adiponectin in patients with erosive (E) and non-erosive (NE) osteoarthritis (OA) of the hand (HOA) compared to normal controls (NC). METHODS: 94 outpatients with E HOA and NE HOA and 21 NC were enrolled. The radiological assessment of both hands was performed according to the Kellgren-Lawrence and Kallman score. Patients were divided into two subsets (lone HOA or generalized OA) based on clinically OA involvement of knee and hip...
November 5, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
Tereza Lennerová, Karel Pavelka, Ladislav Šenolt
Hand osteoarthritis (OA) is a common degenerative joint disorder leading to substantial pain and disability. The most severe subtype is erosive hand OA characterized by an abrupt onset, local inflammation, subchondral erosions and worse outcomes than non-erosive disease. Biomarkers of hand OA could help to diagnose the disease earlier, to distinguish patients with erosive and non-erosive forms, to assess disease severity or to predict its future progression. The objective of this review was to summarize the role of potential biomarkers of hand OA...
November 2, 2017: Rheumatology International
Wan Nurfarahin Wan Osman, Seng Fong Lau, Suhaila Mohamed
The effect of scopoletin-standardized Morinda elliptica leaf extract against osteoarthritis was investigated in ex vivo explant culture and preclinical rodent model. Thirty male rats were grouped (n = 6) into untreated osteoarthritis (OA), OA + Diclofenac (5 mg/kg), and OA + extract (200 and 400 mg/kg) and compared with healthy control. Monosodium iodoacetate were injected into the right intra-articular knee joints to induce OA. The rats were evaluated for OA severity via physical (micro-CT and histological observations), biochemical, ELISA, and mRNA expression analysis (for inflammation and cartilage degradation biomarkers), after 28 days of treatment...
December 2017: Phytotherapy Research: PTR
Christian Dejaco, Andreas Stadlmayr, Christina Duftner, Viktoria Trimmel, Rusmir Husic, Elisabeth Krones, Shahin Zandieh, Emma Husar-Memmer, Gernot Zollner, Josef Hermann, Judith Gretler, Angelika Lackner, Anja Ficjan, Christian Datz, Roland Axman, Jochen Zwerina
BACKGROUND: Chronic arthropathy occurs in approximately two thirds of patients with hereditary haemochromatosis (HH). The aim was to study inflammatory and structural lesions in patients with HH with (HH-A) and without arthropathy (HH-WA) using ultrasonography. METHODS: This was a cross-sectional study of 26 patients with HH-A, 24 with HH-WA and 37 with hand osteoarthritis (HOA). Clinical examination was performed in 68 joints, and we retrieved data on hand function, pain and global disease activity (all using a visual analogue scale (VAS)), morning stiffness and ferritin levels...
October 24, 2017: Arthritis Research & Therapy
Lisa K Stamp, Janine Haslett, Peter Chapman, John O'Donnell, Rafi Raja, Alastair Rothwell, Christopher Frampton, Gary Hooper
OBJECTIVE: To determine rates of joint replacement for people with rheumatoid arthritis (RA) and osteoarthritis (OA) and to examine the characteristics of those receiving elbow replacements. METHODS: Data were extracted from the New Zealand Joint Registry from 1999 to 2015 and annual rates calculated. RESULTS: Rates of joint replacement increased over time for OA but not RA. Elbow replacement was the only procedure performed more commonly in RA...
December 2017: Journal of Rheumatology
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