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https://www.readbyqxmd.com/read/29775407/effect-of-healthy-aging-and-sex-on-middle-cerebral-artery-blood-velocity-dynamics-during-moderate-intensity-exercise
#1
Jaimie L Ward, Jesse C Craig, Yumei Liu, Eric Dennis Vidoni, Rebecca Malesky, David C Poole, Sandra A Billinger
Cerebral blood flow (CBF) velocity measured in the middle cerebral artery (MCAV ) increases with finite kinetics during moderate intensity exercise and both the amplitude and dynamics of the response provide invaluable insights into the controlling mechanisms. The MCAV response following exercise onset is well fit to an exponential model in young individuals but remains to be characterized in their older counterparts. The responsiveness of vasomotor control degrades with advancing age, especially in skeletal muscle, and we tested the hypothesis that older subjects would evince a slower and reduced MCAV response to exercise...
May 18, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29765930/effect-of-fennel-on-the-health-status-of-menopausal-women-a-systematic-and-meta-analysis
#2
Talat Khadivzadeh, Mona Najaf Najafi, Leila Kargarfard, Masumeh Ghazanfarpour, Fatemeh Rajab Dizavandi, Imaneh Khorsand
Objectives: The aim of the present study is the systematic and critical investigation of the effectiveness of fennel on the climacteric symptoms among menopausal females. Methods: A search of the trials studying the effect of fennel on menopausal females was conducted in 2017 using the MEDLINE and Scopus databases and the Cochrane Library with the following keywords: fennel, Foeniculum vulgare , and menopause. Results: Fennel combined with officinalis is more effective in the attenuating of sleep disorders compared to Citalopram...
April 2018: Journal of Menopausal Medicine
https://www.readbyqxmd.com/read/29751093/thyroid-hormones-affect-nitrergic-innervation-function-in-rat-mesenteric-artery-role-of-the-pi3k-akt-pathway
#3
Pablo Llévenes, Gloria Balfagón, Javier Blanco-Rivero
We aimed to determine the influence of nitrergic innervation function on the decreased mesenteric arterial tone induced by high levels of triiodothyronine (T3), as a model of acute thyroiditis, as well as the mechanism/s implicated. We analysed in mesenteric segments from male Wistar rats the effect of 10 nmol/L T3 (2 h) on the vasomotor response to electrical field stimulation (EFS) in the presence/absence of specific neuronal NOS (nNOS) inhibitor L-NPA, or superoxide anion scavenger tempol. Nitric oxide (NO) release was measured in the presence/absence of tempol or PI3K inhibitor LY294002...
May 8, 2018: Vascular Pharmacology
https://www.readbyqxmd.com/read/29748474/lipophilic-chemicals-from-diesel-exhaust-particles-trigger-calcium-response-in-human-endothelial-cells-via-aryl-hydrocarbon-receptor-non-genomic-signalling
#4
Bendik C Brinchmann, Eric Le Ferrec, Normand Podechard, Dominique Lagadic-Gossmann, Kenji F Shoji, Aubin Penna, Klara Kukowski, Alena Kubátová, Jørn A Holme, Johan Øvrevik
Exposure to diesel exhaust particles (DEPs) affects endothelial function and may contribute to the development of atherosclerosis and vasomotor dysfunction. As intracellular calcium concentration [Ca2+ ] i is considered important in myoendothelial signalling, we explored the effects of extractable organic matter from DEPs (DEP-EOM) on [Ca2+ ] i and membrane microstructure in endothelial cells. DEP-EOM of increasing polarity was obtained by pressurized sequential extraction of DEPs with n -hexane ( n -Hex-EOM), dichloromethane (DCM-EOM), methanol, and water...
May 10, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29728013/coronary-and-peripheral-vasomotor-responses-to-mental-stress
#5
Muhammad Hammadah, Jeong Hwan Kim, Ibhar Al Mheid, Ayman Samman Tahhan, Kobina Wilmot, Ronnie Ramadan, Ayman Alkhoder, Mohamed Khayata, Girum Mekonnen, Oleksiy Levantsevych, Yasir Bouchi, Belal Kaseer, Fahad Choudhary, Mohamad M Gafeer, Frank E Corrigan, Amit J Shah, Laura Ward, Michael Kutner, J Douglas Bremner, David S Sheps, Paolo Raggi, Viola Vaccarino, Habib Samady, Kreton Mavromatis, Arshed A Quyyumi
BACKGROUND: Coronary microvascular dysfunction may contribute to myocardial ischemia during mental stress (MS). However, the role of coronary epicardial and microvascular function in regulating coronary blood flow (CBF) responses during MS remains understudied. We hypothesized that coronary vasomotion during MS is dependent on the coronary microvascular endothelial function and will be reflected in the peripheral microvascular circulation. METHODS AND RESULTS: In 38 patients aged 59±8 years undergoing coronary angiography, endothelium-dependent and endothelium-independent coronary epicardial and microvascular responses were measured using intracoronary acetylcholine and nitroprusside, respectively, and after MS induced by mental arithmetic testing...
May 3, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29725283/isoflavones-calcium-vitamin-d-and-inulin-improve-quality-of-life-sexual-function-body-composition-and-metabolic-parameters-in-menopausal-women-result-from-a-prospective-randomized-placebo-controlled-parallel-group-study
#6
Salvatore Giovanni Vitale, Salvatore Caruso, Agnese Maria Chiara Rapisarda, Stefano Cianci, Antonio Cianci
Introduction: Menopause results in metabolic changes that contribute to increase risk of cardiovascular diseases: increase in low density lipoprotein (LDL) and triglycerides and decrease in high density lipoprotein (HDL), weight gain are associated with a correspondent increase in incidence of hypertension and diabetes. The aim of this study was to evaluate the effect of a preparation of isoflavones, calcium vitamin D and inulin in menopausal women. Material and methods: We performed a prospective, randomized, placebo-controlled, parallel-group study...
March 2018: Przeglad Menopauzalny, Menopause Review
https://www.readbyqxmd.com/read/29720945/decrease-of-perivascular-adipose-tissue-browning-is-associated-with-vascular-dysfunction-in-spontaneous-hypertensive-rats-during-aging
#7
Ling-Ran Kong, Yan-Ping Zhou, Dong-Rui Chen, Cheng-Chao Ruan, Ping-Jin Gao
Functional perivascular adipose tissue (PVAT) is necessary to maintain vascular physiology through both mechanical support and endocrine or paracrine ways. PVAT shows a brown adipose tissue (BAT)-like feature and the browning level of PVAT is dependent on the anatomic location and species. However, it is not clear whether PVAT browning is involved in the vascular tone regulation in spontaneously hypertensive rats (SHRs). In the present study, we aimed to illustrate the effect of aging on PVAT browning and subsequent vasomotor reaction in SHRs...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29687617/noninvasive-assessment-of-autonomic-function-in-human-neonates-born-at-the-extremes-of-fetal-growth-spectrum
#8
Hasthi U Dissanayake, Rowena L McMullan, Adrienne Gordon, Ian D Caterson, David S Celermajer, Melinda Phang, Camille Raynes-Greenow, Michael R Skilton, Jaimie W Polson
Birth weight is associated with adult cardiovascular disease, such that those at both ends of the spectrum are at increased risk. This may be driven in part by modification to autonomic control, a mechanistic contributor to hypertension. However, birth weight is a relatively crude surrogate of fetal growth; and newborn body composition may more accurately identify the "at risk" infant. Accordingly, we sought to determine whether newborns with high or low body fat have altered autonomic control of vasomotor function and cardiac contractility...
April 2018: Physiological Reports
https://www.readbyqxmd.com/read/29628894/insulin-receptor-substrate-2-controls-insulin-mediated-vasoreactivity-and-perivascular-adipose-tissue-function-in-muscle
#9
Alexander H Turaihi, Wineke Bakker, Victor W M van Hinsbergh, Erik H Serné, Yvo M Smulders, Hans W M Niessen, Etto C Eringa
Introduction: Insulin signaling in adipose tissue has been shown to regulate insulin's effects in muscle. In muscle, perivascular adipose tissue (PVAT) and vascular insulin signaling regulate muscle perfusion. Insulin receptor substrate (IRS) 2 has been shown to control adipose tissue function and glucose metabolism, and here we tested the hypothesis that IRS2 mediates insulin's actions on the vessel wall as well as the vasoactive properties of PVAT. Methods: We studied PVAT and muscle resistance arteries (RA) from littermate IRS2+/+ and IRS2-/- mice and vasoreactivity by pressure myography, vascular insulin signaling, adipokine expression, and release and PVAT morphology...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29559178/effectiveness-of-complex-regional-pain-syndrome-treatment-a-systematic-review
#10
REVIEW
Andrzej Żyluk, Piotr Puchalski
Complex regional pain syndrome (CRPS) is a descriptive term for a complex of symptoms and signs typically occurring following trauma of the extremity. Typical symptomatology includes severe pain, swelling, vasomotor instability and functional impairment of the affected limb. At present there is no one, effective method of treatment of the condition. A large number of treatments have been investigated but major multicentre randomized controlled trials are lacking. This study presents the results of a systematic review of the evidence on effectiveness of treatment methods in CRPS...
March 12, 2018: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/29558039/analysis-of-peripheral-nerve-and-autonomic-nervous-system-function-and-the-stage-of-microangiopathy-in-patients-with-secondary-raynaud-s-phenomenon-in-the-course-of-connective-tissue-diseases
#11
Izabela Gosk-Bierska, Maria Misterska-Skóra, Marta Wasilewska, Małgorzata Bilińska, Jerzy Gosk, Rajmund Adamiec, Magdalena Koszewicz
BACKGROUND: The pathogenesis of secondary Raynaud's phenomenon (SRP) associated with connective tissue diseases (CTD) is not entirely understood. Nervous system dysfunction and microangiopathy are considered to be causes of this pathology. OBJECTIVES: Peripheral and autonomic nervous system function, the stage of microangiopathy, and the relationships between these in patients with SRP were analyzed. MATERIAL AND METHODS: In the study, 20 patients with CTD-related SRP and 30 healthy controls were subject to capillaroscopy, standard conduction velocity tests and conduction velocity distribution (CVD) tests in ulnar and peroneal nerves, heart rate variability (HRV), and sympathetic skin response (SSR) tests...
March 20, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29542222/mindfulness-cognitive-behavioural-and-behaviour-based-therapy-for-natural-and-treatment-induced-menopausal-symptoms-a-systematic-review-and-meta-analysis
#12
REVIEW
Cmg van Driel, A S Stuursma, M J Schroevers, Mje Mourits, G H de Bock
BACKGROUND: During menopause women experience vasomotor and psychosexual symptoms that cannot entirely be alleviated with hormone replacement therapy (HRT). Besides, HRT is contraindicated after breast cancer. OBJECTIVES: To review the evidence on the effectiveness of psychological interventions in reducing symptoms associated with menopause in natural or treatment-induced menopausal women. SEARCH STRATEGY: Medline/Pubmed, PsycINFO, EMBASE and AMED were searched until June 2017...
March 15, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29536150/association-between-aerobic-fitness-and-cerebrovascular-function-with-neurocognitive-functions-in-healthy-young-adults
#13
Jungyun Hwang, Kiyoung Kim, R Matthew Brothers, Darla M Castelli, F Gonzalez-Lima
Studies of the effects of physical activity on cognition suggest that aerobic fitness can improve cognitive abilities. However, the physiological mechanisms for the cognitive benefit of aerobic fitness are less well understood. We examined the association between aerobic fitness and cerebrovascular function with neurocognitive functions in healthy, young adults. Participants aged 18-29 years underwent measurements of cerebral vasomotor reactivity (CVMR) in response to rebreathing-induced hypercapnia, maximal oxygen uptake (VO2 max) during cycle ergometry to voluntary exhaustion, and simple- and complex-neurocognitive assessments at rest...
March 14, 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29535992/developmental-programming-of-renal-function-and-re-programming-approaches
#14
REVIEW
Eva Nüsken, Jörg Dötsch, Lutz T Weber, Kai-Dietrich Nüsken
Chronic kidney disease affects more than 10% of the population. Programming studies have examined the interrelationship between environmental factors in early life and differences in morbidity and mortality between individuals. A number of important principles has been identified, namely permanent structural modifications of organs and cells, long-lasting adjustments of endocrine regulatory circuits, as well as altered gene transcription. Risk factors include intrauterine deficiencies by disturbed placental function or maternal malnutrition, prematurity, intrauterine and postnatal stress, intrauterine and postnatal overnutrition, as well as dietary dysbalances in postnatal life...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29533368/a-randomized-double-blind-placebo-controlled-trial-of-chinese-herbal-medicine-capsules-for-the-treatment-of-premature-ovarian-insufficiency
#15
Xiao-Jing Cao, Xuchun Huang, Jian Liu, Fei Ma, Yuyan Zeng, Changqian Chen, Ji-Ju Wang, Guangning Nie, Xiao-Yun Wang
OBJECTIVE: This study was conducted to evaluate the treatment effectiveness of Chinese herbal medicine capsules containing the Yangyin Shugan formula (YYSG) in premature ovarian insufficiency (POI). METHODS: One-hundred forty-six women with POI participated in this stratified, randomized, double-blind, placebo-controlled clinical trial. Participants in two groups (n = 73 in each)-the YYSG group and control group-underwent treatment for 12 weeks. Outcome measures included the Chinese version Menopause-Specific Quality of Life questionnaire (CMS), serum levels of basal follicle-stimulating hormone (bFSH), basal estradiol, and anti-Mullerian hormone (AMH), the antral follicle count (AFC), and ovarian peak systolic velocity (PSV; cm/s)...
March 12, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29521311/serial-assessment-of-endothelial-vasomotor-function-using-optimal-medical-therapy-predicts-clinical-outcomes-in-patients-after-complete-coronary-revascularization
#16
Masahide Tokue, Raisuke Iijima, Masao Moroi, Masato Nakamura
OBJECTIVE: Previous studies have demonstrated the importance of intensive optimal medical therapy (OMT) in patients with coronary artery disease (CAD). To investigate our hypothesis that patients with and without OMT achievement differed with respect to the risk of future cardiac events, we investigated the endothelial function in patients with CAD who underwent percutaneous coronary intervention (PCI) and contemporary medical therapy. METHODS: We conducted a prospective longitudinal cohort study to evaluate the endothelial function in 96 consecutive patients at 12 h after admission and 3 months at <12 h after admission and at 3 months after discharge by measuring the brachial artery dilatation after 5 min of forearm ischemia flow-mediated dilation (FMD)...
March 2018: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/29484993/the-use-of-antidepressants-for-physical-and-psychological-symptoms-in-cancer
#17
Syahrir Zaini, N G Chong Guan, Ahmad Hatim Sulaiman, Nor Zuraida Zainal, Hasniza Zaman Huri, Siti Hadijah Shamsudin
: Cancer patients are commonly associated with various physical and psychological symptoms. In view of this matter, palliative care is usually given to relieve those symptoms, improve quality of life, and increase medication adherence. Antidepressants are generally accepted for the treatment of depression among patients with or without cancer. Some other potential benefits of these medications have been experienced in clinical practice. Therefore, this study aimed to review the use of antidepressant for physical and psychological symptoms in cancer...
February 26, 2018: Current Drug Targets
https://www.readbyqxmd.com/read/29482579/vasomotor-function-in-rat-arteries-after-ex-vivo-and-intragastric-exposure-to-food-grade-titanium-dioxide-and-vegetable-carbon-particles
#18
Ditte Marie Jensen, Daniel Vest Christophersen, Majid Sheykhzade, Gry Freja Skovsted, Jens Lykkesfeldt, Rasmus Münter, Martin Roursgaard, Steffen Loft, Peter Møller
BACKGROUND: Humans are continuously exposed to particles in the gastrointestinal tract. Exposure may occur directly through ingestion of particles via food or indirectly by removal of inhaled material from the airways by the mucociliary clearance system. We examined the effects of food-grade particle exposure on vasomotor function and systemic oxidative stress in an ex vivo study and intragastrically exposed rats. METHODS: In an ex vivo study, aorta rings from naïve Sprague-Dawley rats were exposed for 30 min to food-grade TiO2 (E171), benchmark TiO2 (Aeroxide P25), food-grade vegetable carbon (E153) or benchmark carbon black (Printex 90)...
February 26, 2018: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/29438680/ischemia-reperfusion-injury-alters-skin-microvascular-responses-to-local-heating-of-the-index-finger
#19
Gregory W McGarr, Gary J Hodges, Matthew M Mallette, Stephen S Cheung
BACKGROUND: Ischemia-reperfusion (IR) injury impairs microcirculatory function by reducing nitric oxide (NO) bioavailability and increasing sympathetic tone. This study non-invasively examined the effects of acute upper limb IR injury on local thermal hyperemia (LTH) in glabrous and non-glabrous finger skin. MATERIALS AND METHODS: In ten healthy males, LTH was examined twice (~7-10 d apart) for each skin type on the index finger using laser-Doppler flowmetry in a counterbalanced design with either 1) 20 min ischemia, followed by reperfusion (ISCH) or 2) time-matched control (SHAM)...
February 10, 2018: Microvascular Research
https://www.readbyqxmd.com/read/29438648/managing-menopausal-symptoms-after-cancer-an-evidence-based-approach-for-primary-care
#20
Jennifer L Marino, Helen C McNamara, Martha Hickey
Impaired ovarian function and menopausal symptoms are common after cancer treatment. Menopausal symptoms often occur at an earlier age in women with cancer, and may be more severe than in natural menopause; they may be the most persistent and troubling sequelae of cancer. A third of female patients with cancer report dissatisfaction with the quality and length of physician-patient discussions about reproductive health, including menopause. Systemic menopausal hormone therapy is the most effective treatment for menopausal symptoms, but it is not suitable for all patients after cancer - where it is unsuitable, alternative effective non-hormonal treatments are available...
February 19, 2018: Medical Journal of Australia
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