keyword
MENU ▼
Read by QxMD icon Read
search

vasomotor function

keyword
https://www.readbyqxmd.com/read/27923234/transient-receptor-potential-vanilloid-1-channels-contribute-to-the-regulation-of-acid-and-base-induced-vasomotor-responses
#1
Ivan Ivic, Margit Solymar, Eszter Pakai, Zoltan Rumbus, Erika Pinter, Akos Koller, Andras Garami
pH changes can influence local blood flow, but the mechanisms of how acids and bases affect vascular tone is not fully clarified. Transient receptor potential vanilloid-1 (TRPV1) channels are expressed in vessels and can be activated by pH alterations. Thus, we hypothesized that TRPV1 channels are involved in the mediation of vascular responses to acid-base changes. Vasomotor responses to HCl, NaOH, and capsaicin were measured in isolated murine carotid and tail skin arteries. The function of TRPV1 was blocked by either of three approaches: Trpv1 gene disruption, pharmacological blockade with a TRPV1 antagonist (BCTC), and functional impairment of mainly neural TRPV1 channels (desensitization)...
December 7, 2016: Journal of Vascular Research
https://www.readbyqxmd.com/read/27872049/contribution-of-kv1-5-channel-to-h2o2-induced-human-arteriolar-dilation-and-its-modulation-by-coronary-artery-disease
#2
Yoshinori Nishijima, Sheng Cao, Dawid S Chabowski, Ankush Korishettar, Alyce Ge, Xiaodong Zheng, Rodney Sparapani, David D Gutterman, David X Zhang
RATIONALE: Hydrogen peroxide (H2O2) regulates vascular tone in the human microcirculation under physiological and pathophysiological conditions. It dilates arterioles by activating BKCa channels in subjects with coronary artery disease (CAD), but its mechanisms of action in subjects without CAD (non-CAD) as compared to those with CAD remain unknown. OBJECTIVE: We hypothesize that H2O2-elicited dilation involves different K(+) channels in non-CAD versus CAD, resulting in an altered capacity for vasodilation during disease...
November 21, 2016: Circulation Research
https://www.readbyqxmd.com/read/27862767/dynamics-of-cerebral-blood-flow-in-patients-with-mild-non-ischaemic-heart-failure
#3
Christian D Erkelens, Haye H van der Wal, Bauke M de Jong, Jan-Willem Elting, Remco Renken, Marleen Gerritsen, Peter Jan van Laar, Vincent M van Deursen, Peter van der Meer, Dirk J van Veldhuisen, Adriaan A Voors, Gert-Jan Luijckx
AIMS: Heart failure (HF) is associated with tissue hypoperfusion and congestion leading to organ dysfunction. Although cerebral blood flow (CBF) is preserved over a wide range of perfusion pressures in healthy subjects, it is impaired in end-stage HF. We aimed to compare CBF, autoregulation, and cognitive function in patients with mild non-ischaemic HF with healthy controls. METHODS AND RESULTS: Fifteen patients with mild idiopathic dilated cardiomyopathy and 15 matched healthy controls were studied...
November 14, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27858702/both-flow-mediated-dilation-and%C3%A2-constriction-are-associated-with%C3%A2-changes-in%C3%A2-blood-flow-and-shear-stress-%C3%A2-two%C3%A2-complementary-perspectives-on%C3%A2-endothelial-function
#4
Tommaso Gori, Urs von Henning, Selina Muxel, Sarina Schaefer, Federica Fasola, Marcus Vosseler, Boris Schnorbus, Harald Binder, John D Parker, Thomas Münzel
INTRODUCTION: Flow-mediated dilation (FMD) quantifies endothelium-dependent vasomotor responses to short-term increases in blood flow. Low-flow mediated vasoconstriction (L-FMC) has been more recently introduced as additional measure of endothelial function, and its relationship with changes in blood flow, cardiovascular risk factors and FMD ha∧s been less well characterized. MATERIALS AND METHODS: We evaluated radial artery FMD and L-FMC along with the changes in blood flow and shear rate/stress in 584 patients with known or suspected coronary artery disease (72...
November 18, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27852186/supportive-care-of-women-with-breast-cancer-key-concerns-and-practical-solutions
#5
Nicholas Zdenkowski, Stephanie Tesson, Janine Lombard, Melanie Lovell, Sandra Hayes, Prudence A Francis, Haryana M Dhillon, Frances M Boyle
Patients diagnosed with breast cancer may have supportive care needs for many years after diagnosis. High quality multidisciplinary care can help address these needs and reduce the physical and psychological effects of breast cancer and its treatment. Ovarian suppression and extended endocrine therapy benefits are associated with vasomotor, musculoskeletal, sexual and bone density-related side effects. Aromatase inhibitor musculoskeletal syndrome is a common reason for treatment discontinuation. Treatment strategies include education, exercise, simple analgesia and a change to tamoxifen or another aromatase inhibitor...
November 21, 2016: Medical Journal of Australia
https://www.readbyqxmd.com/read/27823739/direct-and-indirect-effects-of-conjugated-estrogens-bazedoxifene-treatment-on-quality-of-life-in-postmenopausal-women
#6
Lucy Abraham, Andrew G Bushmakin, Erika Dragon, Barry S Komm, JoAnn V Pinkerton
OBJECTIVE: Determine the direct and indirect effects of conjugated estrogens/bazedoxifene (CE/BZA) treatment on menopause-specific quality of life in a post-hoc analysis of 2 phase 3 Selective estrogens, Menopause, And Response to Therapy (SMART-1, SMART-2) trials. STUDY DESIGN: Data from participants in SMART-1 and SMART-2 who received CE 0.45mg/BZA 20mg, CE 0.625mg/BZA 20mg, or placebo were analyzed, including week 12 data from 1274 healthy postmenopausal women in SMART-1 and pooled week 1-4 and 9-12 data from 332 women with moderate to severe vasomotor symptoms (≥7 HFs/d or ≥50/wk) in SMART-2...
December 2016: Maturitas
https://www.readbyqxmd.com/read/27818738/differential-effects-between-cigarette-total-particulate-matter-and-cigarette-smoke-extract-on-blood-and-blood-vessel
#7
Jung-Min Park, Kyung-Hwa Chang, Kwang-Hoon Park, Seong-Jin Choi, Kyuhong Lee, Jin-Yong Lee, Masahiko Satoh, Seong-Yu Song, Moo-Yeol Lee
The generation and collection of cigarette smoke (CS) is a prerequisite for any toxicology study on smoking, especially an in vitro CS exposure study. In this study, the effects on blood and vascular function were tested with two widely used CS preparations to compare the biological effects of CS with respect to the CS preparation used. CS was prepared in the form of total particulate matter (TPM), which is CS trapped in a Cambridge filter pad, and cigarette smoke extract (CSE), which is CS trapped in phosphate-buffered saline...
October 2016: Toxicological Research
https://www.readbyqxmd.com/read/27813367/lps-but-not-angiotensin-ll-lnduces-direct-pro-lnflammatory-effects-in-cultured-mouse-arteries-and-human-endothelial-and-vascular-smooth-muscle-cells
#8
Emilie M Outzen, Marina Zaki, Rahila Mehryar, Bahareh Abdolalizadeh, Waseem Sajid, Harrie C M Boonen, Anette Sams, Majid Sheykhzade
Angiotensin II (Ang II) might induce pro-inflammatory effects directly on the vascular wall independently of its hemodynamic effects. The aim of our study was to investigate the putative direct pro-inflammatory and vasomotor effects of Ang II and compare to those of LPS in mouse isolated mesenteric resistance-sized arteries (MRA) supported by experiments in cultured human primary endothelial and vascular smooth muscle cells. Results showed that 24-hr organ culture of mouse MRA with 10 nM Ang II had, unlike 100 ng/mL LPS, no effects on IL-6 or MCP-1 secretion, VCAM1 mRNA expression or endothelial function, while Ang II significantly decreased maximal vasomotor responses to phenylephrine...
November 4, 2016: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/27801542/calcium-and-electrical-signaling-in-arterial-endothelial-tubes-new-insights-into-cellular-physiology-and-cardiovascular-function
#9
Erik J Behringer
The integral role of the endothelium during the coordination of blood flow throughout vascular resistance networks has been recognized for decades. Early examination of the distinct anatomy and physiology of the endothelium as a signaling conduit along the vascular wall has prompted development and application of an intact endothelial "tube" study model isolated from rodent skeletal muscle resistance arteries. Vasodilatory signals such as increased endothelial cell (EC) Ca(2+) ([Ca(2+) ]i ) signals and hyperpolarization can take place in single ECs while being shared between electrically coupled ECs through gap junctions up to distances of millimeters (≥ 2 mm)...
November 1, 2016: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/27793855/functional-vascular-contributions-to-cognitive-impairment-and-dementia-vcid-mechanisms-and-consequences-of-cerebral-microvascular-dysfunction-in-aging
#10
Peter Toth, Stefano Tarantini, Anna Csiszar, Zoltan I Ungvari
Increasing evidence from epidemiological, clinical and experimental studies indicate that age-related cerebromicrovascular dysfunction and microcirculatory damage play critical roles in the pathogenesis of many types of dementia in the elderly, including Alzheimer's disease. Understanding and targeting the age-related pathophysiological mechanisms that underlie vascular contributions to cognitive impairment and dementia (VCID) is expected to have a major role in preserving brain health in older individuals...
October 28, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27783807/cerebral-vasomotor-reactivity-assessment-using-transcranial-doppler-and-mri-with-apnea-test
#11
C R Campos Herrera, G C Beltramini, W M Avelar, F O Lima, L M Li
Differently from previous studies that used Transcranial Doppler (TCD) and functional MRI (fMRI) for cerebral vasomotor reactivity (CVR) assessment in patients with carotid stenosis (CS), we assessed CVR using an identical stimulus, the Breath-Holding Test (BHT). We included 15 patients with CS and 7 age-matched controls to verify whether fMRI responded differently to BHT between groups and to calculate the agreement rate between tests. For TCD, impaired CVR was defined when the mean percentage increase on middle cerebral artery velocities was ≤31% on 3 consecutive 30-s apnea intercalated by 4-min normal breathing intervals...
October 24, 2016: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/27754291/br-08-3-management-of-dyslipidemia-in-hypertension
#12
V V Muthusamy
Cardiovascular disease burden is increasing all over the world. The diagnosis of hypertension is considered when a person has persistently elevated BP (Systolic BP more than 140 mmHg and/or Diastolic BP more than 90 mmHg). Dyslipidemia denotes abnormal levels of lipids in the blood (Total Cholesterol >200 mg%, Low density lipoprotein (LDL) >100 mg%, Triglycerides (TGL) >150 mg% and High density lipoprotein (HDL) <40 mg in men and < 50 mg in women. Hypertension and Dyslipidemia constitute the important components of metabolic syndrome as per the definition of NCEP Guidelines-Adult Treatment Panel III (ATP III)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27752330/radial-artery-vasomotor-function-following-transradial-cardiac-catheterisation
#13
A J Mitchell, N L Mills, D E Newby, N L M Cruden
AIMS: To determine the reproducibility of flow-mediated dilation (FMD) and nitrate-mediated dilation (NMD) in the assessment of radial artery vasomotor function, and to examine the effect of transradial catheterisation on radial artery injury and recovery. METHODS: Radial artery FMD and NMD were examined in 20 volunteers and 20 patients on four occasions (two visits at least 24 hours apart, with two assessments at each visit). In a further 10 patients, radial artery FMD was assessed in the catheterised arm prior to, at 24 hours and 3 months following cardiac catheterisation...
2016: Open Heart
https://www.readbyqxmd.com/read/27747211/subfailure-overstretch-injury-leads-to-reversible-functional-impairment-and-purinergic-p2x7-receptor-activation-in-intact-vascular-tissue
#14
Weifeng Luo, Christy M Guth, Olukemi Jolayemi, Craig L Duvall, Colleen Marie Brophy, Joyce Cheung-Flynn
Vascular stretch injury is associated with blunt trauma, vascular surgical procedures, and harvest of human saphenous vein for use in vascular bypass grafting. A model of subfailure overstretch in rat abdominal aorta was developed to characterize surgical vascular stretch injury. Longitudinal stretch of rat aorta was characterized ex vivo. Stretch to the haptic endpoint, where the tissues would no longer lengthen, occurred at twice the resting length. The stress produced at this length was greater than physiologic mechanical forces but well below the level of mechanical disruption...
2016: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/27699736/-chemotherapy-induced-amenorrhea-and-menopause-symptoms-in-women-with-breast-cancer
#15
Chia-Ying Li, Mei-Ling Chen
Chemotherapy is a common adjuvant therapy for breast cancer that improves survival rates by killing residual cancer cells. However, this intervention may damage the germ cells within the ovary and interrupt the menstrual cycle, ultimately leading to chemotherapy-induced amenorrhea (CIA). The incidence of CIA depends on how broadly this term is defined. Around 75% of premenopausal breast cancer women treated with chemotherapy will develop CIA. Age, having a relatively long chemotherapy cycle duration, being estrogen-receptor positive, and using Tamoxifen all increase the risk of CIA...
October 2016: Hu Li za Zhi the Journal of Nursing
https://www.readbyqxmd.com/read/27699242/flow-metabolism-dissociation-in-the-pathogenesis-of-levodopa-induced-dyskinesia
#16
Vincent A Jourdain, Chris C Tang, Florian Holtbernd, Christian Dresel, Yoon Young Choi, Yilong Ma, Vijay Dhawan, David Eidelberg
Levodopa-induced dyskinesia (LID) is the most common, disruptive complication of Parkinson's disease (PD) pharmacotherapy, yet despite decades of research, the changes in regional brain function underlying LID remain largely unknown. We previously found that the cerebral vasomotor and metabolic responses to levodopa are dissociated in PD subjects. Nonetheless, it is unclear whether levodopa-mediated dissociation is exaggerated in LID or distinguishes LID from non-LID subjects. To explore this possibility, we used dual-tracer positron emission tomography to quantify regional cerebral blood flow and metabolic activity in 28 PD subjects (14 LID, 14 non-LID), scanned before and during intravenous levodopa infusion...
September 22, 2016: JCI Insight
https://www.readbyqxmd.com/read/27676638/menopausal-symptoms-and-cardiovascular-disease-mortality-in-the-women-s-ischemia-syndrome-evaluation-wise
#17
Rebecca C Thurston, B Delia Johnson, Chrisandra L Shufelt, Glenn D Braunstein, Sarah L Berga, Frank Z Stanczyk, Carl J Pepine, Vera Bittner, Steven E Reis, Diane V Thompson, Sheryl F Kelsey, George Sopko, C Noel Bairey Merz
OBJECTIVE: Studies have linked vasomotor symptoms (VMS) to markers of cardiovascular disease (CVD) risk, yet few have considered clinical cardiovascular events. Data suggest that associations may depend upon the age that symptoms occur. We examined associations between VMS and cardiovascular events and endothelial function, considering age of symptom onset. METHODS: The Women's Ischemia Syndrome Evaluation enrolled women referred for coronary angiography for suspected myocardial ischemia...
September 26, 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/27676118/pooled-analysis-of-the-effects-of-conjugated-estrogens-bazedoxifene-on-vasomotor-symptoms-in-the-selective-estrogens-menopause-and-response-to-therapy-trials
#18
David F Archer, Ellen W Freeman, Barry S Komm, Kelly A Ryan, Ching-Ray Yu, Sebastian Mirkin, JoAnn V Pinkerton
OBJECTIVES: Conjugated estrogens/bazedoxifene (CE/BZA) reduced menopause-related hot flashes (HFs) in the Selective estrogens, Menopause, And Response to Therapy (SMART) trials. This post hoc pooled analysis of SMART-1 and -2 further characterized effects of CE/BZA on HFs in the overall population and patient subgroups. METHODS: Data from two randomized, double-blind, placebo- and active-controlled, phase 3 studies were pooled for nonhysterectomized postmenopausal women with moderate/severe HFs given CE 0...
September 27, 2016: Journal of Women's Health
https://www.readbyqxmd.com/read/27644002/controversies-over-the-use-of-gnrh-agonists-for-reduction-of-chemotherapy-induced-gonadotoxicity
#19
M F Garrido-Oyarzún, C Castelo-Branco
The increase in cancer incidence in younger people and the significant improvement in long and permanent remission have brought concern about their reproductive future and quality of life. Up to two-thirds of adult female patients undergoing chemotherapy for malignancies eventually develop premature ovarian failure. This condition is related to many complaints including vasomotor symptoms, osteoporosis, increased risk of cardiovascular diseases, sexual dysfunction, and infertility. Therefore, protection against iatrogenic infertility and loss of endocrine ovarian function caused by chemotherapy is currently of high priority...
September 17, 2016: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/27643289/br-08-3-management-of-dyslipidemia-in-hypertension
#20
V V Muthusamy
Cardiovascular disease burden is increasing all over the world. The diagnosis of hypertension is considered when a person has persistently elevated BP (Systolic BP more than 140 mmHg and/or Diastolic BP more than 90 mmHg). Dyslipidemia denotes abnormal levels of lipids in the blood (Total Cholesterol >200 mg%, Low density lipoprotein (LDL) >100 mg%, Triglycerides (TGL) >150 mg% and High density lipoprotein (HDL) <40 mg in men and < 50 mg in women. Hypertension and Dyslipidemia constitute the important components of metabolic syndrome as per the definition of NCEP Guidelines-Adult Treatment Panel III (ATP III)...
September 2016: Journal of Hypertension
keyword
keyword
73800
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"