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https://www.readbyqxmd.com/read/29050185/-optical-coherence-tomography-angiography-of-acute-vogt-koyanagi-harada-disease
#1
S S Jia, C Zhao, D Gong, Z Chen, M F Zhang
Objective: To measure vascular density in retinal and choroidal capillary layers by optical coherence tomography angiography (OCTA) and to explore their potential clinical values in Vogt-Koyanagi-Harada disease (VKH). Methods: This is a cross-sectional case-control study. Twenty-one acute VKH cases presented to Peking Union Medical College Hospital between April 2015 and July 2015 and 49 healthy controls were enrolled in this study. OCTA was performed with a split-spectrum amplitude-decorrelation angiography-optical coherence tomography (SSADA-OCT) system borrowed from Optovue Inc...
October 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29049726/comparison-of-sectoral-structure-function-relationships-in-glaucoma-vessel-density-versus-thickness-in-the-peripapillary-retinal-nerve-fiber-layer
#2
Kimikazu Sakaguchi, Tomomi Higashide, Sachiko Udagawa, Shinji Ohkubo, Kazuhisa Sugiyama
Purpose: To compare the sectoral structure-function relationships in glaucoma between two structural parameters, vessel density (VD) and thickness, in the peripapillary retinal nerve fiber layer (RNFL). Methods: Optical coherence tomography (OCT) angiography (AngioVue/RTVue-XR) for VD and OCT (RS-3000) for peripapillary RNFL thickness were performed in 129 eyes from 129 subjects (94 glaucoma, 17 glaucoma suspects, and 18 normal eyes). Humphrey visual field (VF) tests were performed using a SITA standard 24-2 program...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29049720/optical-coherence-tomography-angiography-in-the-evaluation-of-geographic-atrophy-area-extension
#3
Eleonora Corbelli, Riccardo Sacconi, Alessandro Rabiolo, Stefano Mercuri, Adriano Carnevali, Lea Querques, Francesco Bandello, Giuseppe Querques
Purpose: To investigate the application of optical coherence tomography angiography (OCT-A) in evaluation of geographic atrophy (GA) secondary to age-related macular degeneration (AMD). Methods: Patients with GA were prospectively enrolled and studied with blue fundus autofluorescence (FAF), en face structural OCT, and OCT-A. OCT-A images were acquired using a slab of whole choroid, whereas en face structural OCT images were obtained at the ellipsoid zone (EZ), at the choroidal (CH) level, and at the scleral (SC) level...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29049718/wide-field-oct-angiography-investigation-of-the-relationship-between-radial-peripapillary-capillary-plexus-density-and-nerve-fiber-layer-thickness
#4
Yali Jia, Joseph M Simonett, Jie Wang, Xiaohui Hua, Liang Liu, Thomas S Hwang, David Huang
Purpose: To characterize the density and distribution of the radial peripapillary capillary plexus (RPCP) and its relationship with retinal nerve fiber layer (NFL) thickness in healthy subjects. Methods: Using spectral-domain optical coherence tomography (OCT), split-spectrum amplitude decorrelation angiography algorithm and automated montaging, wide-field OCT angiography (OCTA) was used to measure the RPCP capillary density (CD) and NFL thickness. Polar sector-average CD and thickness maps were also created on each eye...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29049034/complex-based-oct-angiography-algorithm-recovers-microvascular-information-superior-to-amplitude-or-phase-based-algorithm-in-phase-stable-systems
#5
Jingjiang Xu, Shaozhen Song, Yuandong Li, Ruikang K Wang
Optical coherence tomography angiography (OCTA) is increasingly becoming a popular inspection tool for biomedical imaging applications. By exploring amplitude, phase and complex information available in the OCT signals, numerous algorithms are proposed to contrast functional vessel networks with microcirculation tissue beds. However, it is not clear which algorithm delivers optimal imaging performance. Here, we investigate systematically how the amplitude and phase information would have an impact on the OCTA imaging performance, upon which to establish the relationship of amplitude and phase stability with OCT signal-to-noise ratio (SNR), time interval and particle dynamics...
October 19, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29047360/comparison-of-circulating-dendritic-cell-and-monocyte-subsets-at-different-stages-of-atherosclerosis-insights-from-optical-coherence-tomography
#6
Jianhui Zhuang, Yang Han, Dachun Xu, Guofu Zhu, Shekhar Singh, Luoman Chen, Mengyun Zhu, Wei Chen, Yawei Xu, Xiankai Li
BACKGROUND: While specific patterns of circulating dendritic cells (DCs) and monocytes are associated with the incidence of coronary artery disease, the characterization of circulating DC and monocyte subsets in patients with different stages of atherosclerosis remains unclear. METHODS: Forty-eight patients with unstable angina pectoris (UAP) diagnosed by angiography were enrolled. Likewise, 31 patients with ST-segment elevation myocardial infarction (STEMI) were enrolled and confirmed with the presence of thrombosis by angiography...
October 18, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29044926/optical-coherence-tomography-guided-carotid-artery-stent-procedure-technique-and-potential-applications
#7
Suhail Dohad, Alexander Zhu, Sandeep Krishnan, Frances Wang, Serena Wang, Justin Cox, Timothy D Henry
OBJECTIVES: To (1) present a guide on how to perform optical coherence tomography (OCT) in carotid artery stenting (CAS), to (2) highlight several instructive cases illustrating OCT-guidance as an interventional strategy, and to (3) present the largest case-series of OCT-guided CAS performed in North America, demonstrating its feasibility as an imaging modality in this setting. BACKGROUND: OCT is an intravascular imaging method that captures images with an axial resolution 10 times higher than intravascular ultrasound...
October 16, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29044086/optical-coherence-tomography-angiography-of-circumscribed-choroidal-hemangioma-treated-with-photodynamic-therapy
#8
Giuseppe Lo Giudice, Alessandro Galan
We describe features of a circumscribed choroidal hemangioma (CCH) treated with photodynamic therapy (PDT) by means of optical coherence tomography angiography (OCT-A). A 40-year-old man had a complaint of decreasing visual acuity in his left eye for 10 days. A diagnosis of CCH was confirmed by fundus examination, fluorescein angiography, and indocyanine green angiography. An OCT-A study of choroidal lesion before and after PDT was carried out. Segmented en face OCT-A of CCH showed multiple irregular connected vascular channels with hyperflow and a capillary-like lesion...
October 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29040211/altered-macular-microvasculature-in-mild-cognitive-impairment-and-alzheimer-disease
#9
Hong Jiang, Yantao Wei, Yingying Shi, Clinton B Wright, Xiaoyan Sun, Giovanni Gregori, Fang Zheng, Elizabeth A Vanner, Byron L Lam, Tatjana Rundek, Jianhua Wang
BACKGROUND: The goal of the present study was to analyze the macular microvacular network in mild cognitive impirment (MCI) and Alzheimer disease (AD). METHODS: Twelve patients with AD and 19 patients with MCI were recruited together with 21 cognitively normal controls with a similar range of ages. Optical coherence tomography angiography was used to image the retinal microvascular network at the macular region, including retinal vascular network (RVN), superficial vascular plexus (SVP), and deep vascular plexus (DVP)...
October 16, 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/29040047/ultra-widefield-fluorescein-angiography-in-intermediate-uveitis
#10
Wipada Laovirojjanakul, Nisha Acharya, John A Gonzales
PURPOSE: To examine associations between pattern of vascular leakage on ultrawide-field fluorescein angiography (UWFFA) and visual acuity, cystoid macular edema (CME), and inflammatory activity in intermediate uveitis. METHODS: Single center cross-sectional, retrospective review of medical records, spectral domain optical coherence tomography (SD-OCT) and angiographic images of intermediate uveitis patients who underwent UWFFA over a 12-month period. RESULTS: Forty-one eyes from 24 patients were included...
October 17, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29038969/microvascular-imaging-and-monitoring-of-human-oral-cavity-lesions-in-vivo-by-swept-source-oct-based-angiography
#11
Wei Wei, Woo June Choi, Ruikang K Wang
We report the development of optical coherence tomography- (OCT) based angiography (OCTA) to image blood flow within microcirculatory tissue beds in human oral cavity in vivo with a field of view at 10 mm × 10 mm. Three-dimensional (3D) structural and vascular images of labial mucosa tissue are obtained at a single 3D acquisition. Pathologic mucosal sites with mouth ulcers are examined using the OCT tomograms and angiograms, upon which to monitor the lesion healing process over a period of 2 weeks. Quantitative metrics of the capillary loop density within the lamina propria layer are evaluated, providing statistically significant difference between healthy and diseased conditions over time...
October 16, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/29034359/the-definition-rationale-and-effects-of-thresholding-in-oct-angiography
#12
Emily D Cole, Eric M Moult, Sabin Dang, WooJhon Choi, Stefan B Ploner, ByungKun Lee, Ricardo Louzada, Eduardo Novais, Julia Schottenhamml, Lennart Husvogt, Andreas Maier, James G Fujimoto, Nadia K Waheed, Jay S Duker
PURPOSE: To examine the definition, rationale, and effects of thresholding in OCT angiography (OCTA). DESIGN: A theoretical description of OCTA thresholding in combination with qualitative and quantitative analysis of the effects of OCTA thresholding in eyes from a retrospective case series. PARTICIPANTS: Four eyes were qualitatively examined: 1 from a 27-year-old control, 1 from a 78-year-old exudative age-related macular degeneration (AMD) patient, 1 from a 58-year-old myopic patient, and 1 from a 77-year-old nonexudative AMD patient with geographic atrophy (GA)...
September 2017: Ophthalmology retina
https://www.readbyqxmd.com/read/29028985/impact-of-coronary-lumen-reconstruction-on-the-estimation-of-endothelial-shear-stress-in-vivo-comparison-of-three-dimensional-quantitative-coronary-angiography-and-three-dimensional-fusion-combining-optical-coherent-tomography
#13
Jihoon Kweon, Soo-Jin Kang, Young-Hak Kim, June-Goo Lee, Seungbong Han, Hojin Ha, Dong Hyun Yang, Joon-Won Kang, Tae-Hwan Lim, Osung Kwon, Jung-Min Ahn, Pil Hyung Lee, Duk-Woo Park, Seung-Whan Lee, Cheol Whan Lee, Seong-Wook Park, Seung-Jung Park
Aims: It is not clearly elucidated how the fusion technique improves the accuracy of endothelial shear stress (ESS) prediction, in comparison with that of three-dimensional (3D) quantitative coronary angiography (QCA) alone. We aimed to evaluate the difference in geometric measurements and haemodynamic estimation between 3D QCA and a 3D fusion model combining 3D QCA and optical coherence tomography (OCT). Methods and results: Computational fluid dynamics was assessed in the coronary models of 20 patients...
September 25, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29027737/an-optical-coherence-tomography-study-of-neointimal-morphology-and-strut-coverage-at-different-time-intervals-from-implantation-of-biodegradable-polymer-coated-sirolimus-eluting-stents
#14
Jacek Legutko, Robert J Gil, Pawel E Buszman, Grzegorz L Kaluza, Gary S Mintz, Tomasz Roleder, Marek Krol, Roman Wojdyla, Tomasz Pawlowski, Michal Brzezinski, Marek Kondys, Bartosz Skwarna, Jacek Jakala, Wojciech Zasada, Lukasz Partyka, Dariusz Dudek
OBJECTIVES: The aim of the study was to capture the evolution of neointima after implantation of a biodegradable polymer-coated, sirolimus-eluting, cobalt-chromium coronary stent system (BP-DES). BACKGROUND: Optical coherence tomography (OCT) suggests that in-stent neointimal morphology influences clinical outcomes after DES implantation. METHODS: Sixty patients treated with single BP-DES implantation were examined by quantitative coronary angiography (QCA) and OCT at 3, 6, and 12-month follow-up...
October 13, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29023498/incidence-and-risk-factors-of-massive-subretinal-hemorrhage-in-retinal-angiomatous-proliferation
#15
Jae Hyung Lee, Mee Yon Lee, Won Ki Lee
OBJECTIVE: To evaluate the incidence and associated risk factors of massive subretinal hemorrhage (SRH) in patients with retinal angiomatous proliferation (RAP). METHODS: A total of 187 eyes of 135 treatment-naıve patients diagnosed with RAP were evaluated retrospectively. Clinical records including the time between the initial visit, last anti-vascular endothelial growth factor (VEGF) treatment, last stable examination, and the date of massive SRH were reviewed...
2017: PloS One
https://www.readbyqxmd.com/read/29020026/features-of-the-normal-choriocapillaris-with-oct-angiography-density-estimation-and-textural-properties
#16
Giovanni Montesano, Davide Allegrini, Leonardo Colombo, Luca M Rossetti, Alfredo Pece
The main objective of our work is to perform an in depth analysis of the structural features of normal choriocapillaris imaged with OCT Angiography. Specifically, we provide an optimal radius for a circular Region of Interest (ROI) to obtain a stable estimate of the subfoveal choriocapillaris density and characterize its textural properties using Markov Random Fields. On each binarized image of the choriocapillaris OCT Angiography we performed simulated measurements of the subfoveal choriocapillaris densities with circular Regions of Interest (ROIs) of different radii and with small random displacements from the center of the Foveal Avascular Zone (FAZ)...
2017: PloS One
https://www.readbyqxmd.com/read/28993001/absence-of-adventitial-vasa-vasorum-formation-at-the-coronary-segment-with-myocardial-bridge-an-optical-coherence-tomography-study
#17
Kensuke Nishimiya, Yasuharu Matsumoto, Hongxin Wang, Zhonglie Piao, Kazuma Ohyama, Hironori Uzuka, Kiyotaka Hao, Ryuji Tsuburaya, Jun Takahashi, Kenta Ito, Hiroaki Shimokawa
BACKGROUND: Myocardial bridge (MB) is a myocardial bundle through which coronary segment tunnels and could compress coronary arteries causing myocardial ischemia. However, the characteristic structural findings of MB remain to be fully elucidated. Recently, we demonstrated that optical coherence tomography (OCT) enables us to visualize adventitial vasa vasorum (VV) formation in humans. In this study, we examined adventitial VV formation at the coronary segment with MB in humans using OCT...
October 4, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28991833/optical-coherence-tomography-angiography-vessel-density-measurements-in-eyes-with-primary-open-angle-glaucoma-and-disc-hemorrhage
#18
Harsha L Rao, Zia S Pradhan, Robert N Weinreb, Srilakshmi Dasari, Mohammed Riyazuddin, Jayasree P Venugopal, Narendra K Puttaiah, Dhanaraj A S Rao, Sathi Devi, Kaweh Mansouri, Carroll A B Webers
PURPOSE: To compare the vessel density measurements of optic nerve head, peripapillary and macular regions in severity-matched primary open-angle glaucoma (POAG) eyes with and without disc hemorrhage (DH) using optical coherence tomography (OCT) angiography, and to compare their diagnostic abilities with that of the rim area, retinal nerve fiber layer and the ganglion cell complex thickness measurements on OCT. METHODS: In a cross-sectional study, 66 eyes of 46 control subjects, 34 eyes of 33 POAG patients with DH (median mean deviation=-3...
October 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28986595/comparison-of-neovascular-lesion-area-measurements-from-different-swept-source-oct-angiographic-scan-patterns-in-age-related-macular-degeneration
#19
COMPARATIVE STUDY
Fang Zheng, Qinqin Zhang, Elie H Motulsky, João Rafael de Oliveira Dias, Chieh-Li Chen, Zhongdi Chu, Andrew R Miller, William Feuer, Giovanni Gregori, Sophie Kubach, Mary K Durbin, Ruikang K Wang, Philip J Rosenfeld
Purpose: We compared area measurements for the same neovascular lesions imaged using swept source optical coherence tomography angiography (SS-OCTA) and enlarging scan patterns. Methods: Patients with neovascular age-related macular degeneration were imaged using a 100-kHz SS-OCTA instrument (PLEX Elite 9000). The scanning protocols included the 3 × 3, 6 × 6, 9 × 9, and 12 × 12 mm fields of view. Two groups were studied. Group 1 included small lesions contained within the 3 \( \times \) 3 mm scan, and Group 2 included larger lesions that were fully contained within the 6 \( \times \) 6 mm scan...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28983872/pearls-and-pitfalls-of-optical-coherence-tomography-angiography-in-the-multimodal-evaluation-of-uveitis
#20
REVIEW
Francesco Pichi, David Sarraf, Mariachiara Morara, Shahana Mazumdar, Piergiorgio Neri, Vishali Gupta
BACKGROUND: Optical coherence tomography angiography (OCTA) employs a novel imaging algorithm that detects the amplitude or phase decorrelation of blood cell movement. It thus provides a flow map with depth-resolved visualization of the various vascular layers in the posterior pole of the eye including the retina capillary plexus and the choroid. In the past 3 years, the number of research papers on the subject of OCTA in retinal diseases has grown exponentially including important applications in the field of uveitis...
October 5, 2017: Journal of Ophthalmic Inflammation and Infection
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