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OCT angiography

Sasan Moghimi, Linda M Zangwill, Rafaella C Penteado, Kyle Hasenstab, Elham Ghahari, Huiyuan Hou, Mark Christopher, Adeleh Yarmohammadi, Patricia Isabel C Manalastas, Takuhei Shoji, Christopher Bowd, Robert N Weinreb
PURPOSE: To investigate prospectively the relationship between macular and peripapillary vessel density and progressive retinal nerve fiber layer (RNFL) loss in patients with mild to moderate primary open-angle glaucoma. DESIGN: Prospective, observational study. PARTICIPANTS: One hundred thirty-two eyes of 83 patients with glaucoma followed up for at least 2 years (average: 27.3±3.36 months). METHODS: Measurements of macular whole image vessel density (m-wiVD) and optic nerve head whole image vessel density (onh-wiVD) were acquired at baseline using OCT angiography...
June 12, 2018: Ophthalmology
Stephen Wai Luen Lee, Frankie C C Tam, Kelvin K W Chan, Simon C C Lam, Shun-Ling Kong, Catherine P Shea, Michael K L Wong, Anthony Y T Wong, Arthur S Y Yung, Li-Wei Zhang, Yui-Ming Lam, Gary S Mintz, Ricardo A Costa, Hans-Peter Stoll, Akiko Maehara
AIMS: In patients at high bleeding risk treated with 1 month of dual antiplatelet therapy, the polymer-free, biolimus A9-coated BioFreedom stent (BFS) was found safer and more efficacious than bare metal stents. We used sequential optical coherence tomography (OCT) to assess the time course of strut coverage and neointimal transformation from 1 to 9 months. METHODS AND RESULTS: We randomly assigned 104 BFS recipients to 1 of 5 groups with angiography and OCT follow-up at 1, 2, 3, 4, or 5 months, together with another follow-up for all at 9 months...
June 12, 2018: EuroIntervention
Kenji Sakamoto, Suguru Nagamatsu, Eiichiro Yamamoto, Koichi Kaikita, Kenichi Tsujita
In the past decades, coronary imaging has evolved as a valuable adjunct to angiography, providing scientific insights into vascular biology and practical guidance by direct visualization of atherosclerosis and other pathologic conditions within the vessel walls. Especially with intravascular ultrasound (IVUS), the signal is able to penetrate below the luminal surface, so the entire cross-section of an artery, including the complete thickness of the plaque, can be imaged in real-time. On the other hand, optical coherence tomography (OCT) has been offering higher image resolution of both the plaque and the luminal surface...
June 13, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
Jing-Yu Min, Yanan Lv, Suqin Yu, Yuan-Yuan Gong
PURPOSE: The present study analyzed the appearances of optical coherence tomography angiography (OCTA) in patients with central serous chorioretinopathy (CSC) based on fluorescein angiography (FA) and indocyanine green angiography (ICGA). METHOD: In the current case series, 54 eyes of 50 patients diagnosed as CSC were evaluated retrospectively. OCTA, FA, and ICGA were performed on each patient. Two trained observers examined the OCTA images independently to confirm and compare the choriocapillary appearance with that on FA/ICGA...
June 12, 2018: Lasers in Surgery and Medicine
Tomoaki Murakami, Kiyoshi Suzuma, Yoko Dodo, Tatsuya Yoshitake, Shota Yasukura, Hideo Nakanishi, Masahiro Fujimoto, Maho Oishi, Akitaka Tsujikawa
Diabetic hyperreflective foci in the outer retinal layers are a clinically relevant finding on optical coherence tomography (OCT) images, although their characteristics remain to be elucidated. Here we investigated the decorrelation signal around hyperreflective foci on OCT angiography (OCTA) images in diabetic retinopathy (DR). We retrospectively reviewed sufficient quality OCTA images from 102 eyes of 66 patients that were obtained using split-spectrum amplitude-decorrelation angiography algorithm. Most confluent hyperreflective foci were randomly deposited or appeared in a radiating array on the en-face structural OCT images in the inner nuclear layer (INL) or Henle's fiber layer (HFL), respectively...
June 11, 2018: Scientific Reports
Ahmed M Hagag, Alex D Pechauer, Liang Liu, Jie Wang, Miao Zhang, Yali Jia, David Huang
Purpose: Use projection-resolved OCT angiography to investigate the autoregulatory response in the 3 parafoveal retinal plexuses under hyperoxia. Design: Prospective cohort study. Participants: Nine eyes from 9 healthy participants. Methods: One eye from each participant was scanned using a commercial spectral-domain OCT system. Two repeated macular scans (3 × 3 mm2 ) were acquired at baseline and during oxygen breathing...
April 2018: Ophthalmology Retina
Mohammad Abualhin, Alessia Sonetto, Gianluca Faggioli, Michele Mirelli, Antonio Freyrie, Enrico Gallitto, Andrea Stella, Mauro Gargiulo
INTRODUCTION: The aim of the study was to evaluate the outcomes of Duplex Ultrasonoghraphy(DUS) guided autologous vein bypass to paramalleolar (distal third of tibial arteries and peroneal artery) and inframalleolar arteries (dorsalis pedis, common plantar, medial and lateral plantar arteries) in patients with critical limb ischemia (CLI) and extensive tibial arteries disease TASC D. METHODS: Between January 2007 and October 2016, all paramalleolar or inframalleolar bypasses performed in patients with CLI, planned only on the basis of DUS were collected and analyzed retrospectively...
June 7, 2018: Annals of Vascular Surgery
Enrico Borrelli, Siva Balasubramanian, Giacinto Triolo, Piero Barboni, SriniVas R Sadda, Alfredo A Sadun
PURPOSE: To study the macular microvascular networks in patients affected by chronic Leber's hereditary optic neuropathy (LHON) using optical coherence tomography angiography (OCTA), and to quantify these changes in different macular sectors. DESIGN: Prospective cross-sectional study. METHODS: Patients with a clinical and molecularly confirmed diagnosis of LHON (affected patients in the chronic stage) were enrolled from the neuro-ophthalmology clinic at the Doheny-UCLA...
June 6, 2018: American Journal of Ophthalmology
Hae-Young Lopilly Park, Soo Ji Jeon, Chan Kee Park
PURPOSE: Optical coherence tomography angiography (OCT-A) was used to investigate the features of choroidal microcirculation within the β-zone peripapillary atrophy (PPA) and its association with visual field (VF) defects in myopic patients. DESIGN: A cross-sectional study. METHODS: Participants: Eighty-four myopic patients with a unilateral glaucomatous VF defect. OBSERVATION PROCEDURES: Comparison was performed between VF-affected eyes and contralateral normal eyes...
June 5, 2018: American Journal of Ophthalmology
Yinchen Shen, Xun Xu, Hui Cao
BACKGROUND: Pigmented paravenous retinochoroidal atrophy (PPRCA) is an unusual retinal degeneration, and its performance on optical coherence tomography angiography (OCTA) is unclear. We report a Chinese female case of PPRCA and her OCTA features. CASE PRESENTATION: A 66-year-old female patient was referred to the author's center for gradual progressive loss of vision in both eyes and photophobia of 2 years duration. She reported having no family history of inherited ocular diseases...
June 7, 2018: BMC Ophthalmology
Guodong Liu, Ding Xu, Fang Wang
Diabetic retinopathy (DR) is one of the most common diabetic complications, which has become a leading cause for vision loss, mainly because of macular edema and vitreous hemorrhage. Optical coherence tomography (OCT) angiography is a novel technique to visualize vascular changes including microaneurysm, non-perfusion area, intraretinal microvascular abnormalities, and neovascularization. Recently, it is possible to quantify vascular density, foveal avascular zone area, non-perfusion area objectively using OCT angiography...
June 4, 2018: Diabetes Research and Clinical Practice
Yasuo Yanagi, Aditi Mohla, Shu Yen Lee, Ranjana Mathur, Choi Mun Chan, Ian Yeo, Tien Yin Wong, Chui Ming Gemmy Cheung
Importance: Since the advent of optical coherence tomography angiography (OCT-A), nonexudative neovascularization has been described in the fellow eyes of unilateral exudative age-related macular degeneration (AMD). However, there is limited literature describing the natural course and optimal management of these lesions. Objective: To determine the incidence of fellow eye involvement in patients presenting with unilateral typical AMD or polypoidal choroidal vasculopathy and to evaluate the patterns of OCT-A changes within 6 months before the onset of exudative changes, especially focusing on nonexudative neovascularization...
June 7, 2018: JAMA Ophthalmology
Francesco Romano, Alessandro Arrigo, Soon Wai Chʼng, Maurizio Battaglia Parodi, Maria Pia Manitto, Elisabetta Martina, Francesco Bandello, Paulo E Stanga
PURPOSE: To assess foveal and parafoveal vasculature at the superficial capillary plexus, deep capillary plexus, and choriocapillaris of patients with X-linked retinoschisis by means of optical coherence tomography angiography. METHODS: Six patients with X-linked retinoschisis (12 eyes) and seven healthy controls (14 eyes) were recruited and underwent complete ophthalmologic examination, including best-corrected visual acuity, dilated fundoscopy, and 3 × 3-mm optical coherence tomography angiography macular scans (DRI OCT Triton; Topcon Corp)...
June 5, 2018: Retina
Bert Müller, Janina Tatsios, Jan Klonner, Daniel Pilger, Antonia M Joussen
PURPOSE: To evaluate the efficacy of navigated focal laser photocoagulation in patients with chronic central serous chorioretinopathy (CSCR) and active leakage on fluorescein angiography (FA). METHODS: Thirty-two eyes of 32 patients (age 48 ± 11, m/f = 24/8) with persistent or recurrent CSCR (> 3 months) who received navigated laser photocoagulation (Navilas®) of leaking point(s) between June 2013 and 2016 were included in this retrospective case series...
June 6, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Paolo Milani, Giovanni Montesano, Luca Rossetti, Fulvio Bergamini, Alfredo Pece
PURPOSE: To investigate foveal avascular zone area, macular vascular density, choroidal thickness, and outer retina and choriocapillaris flow in myopic eyes by OCT angiography. METHODS: Automated macular maps and flow calculations were retrospectively evaluated in 42 myopic and in 40 control eyes. RESULTS: Myopic eyes presented lower whole superficial vessel density (46.4 ± 4.9 vs. 51.6 ± 3.6%, P < 0.0001) and higher flow area in the outer retina (1...
June 6, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Tingting Gao, Jinfeng Qu, Jing Xiao, Jie Hu, Mingwei Zhao
PURPOSE: To evaluate the efficacy of half-dose photodynamic therapy (PDT) for the treatment of bullous retinal detachment. METHODS: Interventional prospective case series in six eyes from six consecutive patients with bullous retinal detachment. The effected eyes were treated with indocyanine green angiography (ICGA)-guided half-dose PDT with multifocal and large laser spots. Clinical evaluations included best-corrected visual acuity (BCVA), ophthalmoscopy, ophthalmic B scan, fundus fluorescein angiography (FFA), optical coherence tomography (OCT), and ICGA at each scheduled visit at baseline; at 1, 3, and 6 months after PDT; and during follow-up after 6 months...
June 4, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Fangyao Tang, Zihan Sun, Raymond Wong, Jerry Lok, Alexander Lam, Clement C Tham, Carmen Km Chan, Shaheeda Mohamed, Thomas Ch Lam, Simon Kh Szeto, Danny S Ng, Carol Y Cheung
AIM: To examine the correlation of best-corrected visual acuity (BCVA) with intercapillary area (ICA) measured from optical coherence tomography angiography (OCT-A) in patients with diabetes, and to compare the strength of associations between BCVA with ICA and other OCT-A metrics. METHODS: A cross-sectional study involved 447 eyes from 299 patients with diabetes. All participants underwent OCT-A with a swept-source OCT (Triton DRI-OCT, Topcon, Tokyo, Japan). An automated customised MATLAB programme was used to quantify ICA (the mean of the 10 largest areas including foveal avascular zone (FAZ) area (ICA10_FAZ) and excluding FAZ area (ICA10_excFAZ)) and other OCT-A metrics (FAZ area, FAZ circularity and vessel density) from the macular OCT-A images...
June 4, 2018: British Journal of Ophthalmology
Fatih Horozoğlu, Sever Özkan
BACKGROUND: Intravitreal steroid injection is one of the treatment choices in diabetic macular edema (DME). Dexamethasone (Dx) implant is the most novel form of intravitreal steroid therapy. Macular thickness improvement is well known effect of Dx implant however; subfoveal choroidal coat thickness (SFCT) changes need to be investigated. AIMS: To evaluate the early central macular thickness (CMT) and SFCT alterations after single dose dexamethasone implant injection in DME...
June 5, 2018: Balkan Medical Journal
Xiao Na Wang, Qi Sheng You, Hui Ying Zhao, Xiao Yan Peng
OBJECTIVE: To investigate optical coherence tomography (OCT) characteristics of tuberculous serpiginous-like choroiditis (Tb-SLC) and serpiginous choroiditis (SC) and to perform OCT to differentiate between these conditions. METHODS: This retrospective, case-control study examined consecutively enrolled patients with active Tb-SLC or SC. Patients underwent comprehensive ocular examinations and imaging (OCT, color fundus photography, autofluorescence imaging, fluorescein angiography, and indocyanine green angiography)...
May 2018: Biomedical and Environmental Sciences: BES
Marco Pellegrini, Federico Corvi, Alessandro Invernizzi, Vittoria Ravera, Matteo G Cereda, Giovanni Staurenghi
PURPOSE: To describe the imaging features of choroidal melanoma using swept-source optical coherence tomography angiography (SS-OCT-A) and to evaluate its ability to display tumor intrinsic vasculature. METHODS: Consecutive patients diagnosed with choroidal melanoma underwent a complete ophthalmic evaluation, including best-corrected visual acuity, color fundus photography, B-scan ultrasound, fluorescein angiography, indocyanine green angiography, and SS-OCT-A (PLEX Elite 9000; Carl Zeiss Meditec, Inc, Dublin, CA)...
May 8, 2018: Retina
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