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https://www.readbyqxmd.com/read/29934999/enhanced-hplc-ms-ms-method-for-the-quantitative-determination-of-the-co-administered-drugs-ceftriaxone-sodium-and-lidocaine-hydrochloride-in-human-plasma-following-an-intramuscular-injection-and-application-to-a-pharmacokinetic-study
#1
Dalia Mohamed, Maha Kamal
A sensitive HPLC-MS/MS method was established for the quantification of ceftriaxone sodium (CFT) and lidocaine HCl (LDC) in human plasma utilizing cefixime (CFX) and tadalafil (TDA) as internal standards. The analytes were extracted from human plasma by protein precipitation using acetonitrile. Chromatographic separation was performed on Kinetex C18 (50.0 x 4.6 mm, 5 μm particle size) column with methanol: 0.01 M ammonium acetate pH 6.4 (70: 30, v/v) as mobile phase. Multiple reaction monitoring involving the transitions 555...
June 22, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29933035/two-decades-of-research-in-discovery-of-anticancer-drugs-targeting-stat3-how-close-are-we
#2
REVIEW
Jenny Beebe, Jing-Yuan Liu, Jian-Ting Zhang
Signal transducer and activator of transcription 3 (STAT3) controls many biological processes including differentiation, survival, proliferation, and angiogenesis. In normal healthy cells, STAT3 is tightly regulated to maintain a momentary active state. However, aberrant or constitutively activated STAT3 has been observed in many different cancers and constitutively activated STAT3 has been shown to associate with poor prognosis and tumor progression. For this reason, STAT3 has been studied as a possible target in the treatment of many different types of cancers...
June 19, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29932973/combinatorial-treatment-of-rhizoma-paridis-saponins-and-sorafenib-overcomes-the-intolerance-of-sorafenib
#3
Jingwen Yao, Shuli Man, Honghong Dong, Li Yang, Long Ma, Wenyuan Gao
Sorafenib, as a multi-kinase inhibitor, was the first FDA-approved anti- hepatocellular carcinoma (HCC) drug. Rhizoma Paridis saponins (RPS) as natural products have shown antitumor activity through regulation of glycolytic and lipid metabolism which was regarded as the side effect limited the utility of sorafenib. In this research, we tried to use metabolomics to verify the probability of combinatorial treatment of RPS and Sorafenib. As a result, Sorafenib + RPS increased the antitumor effect of sorafenib and RPS in H22 mice...
June 19, 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29932943/synthetic-lethal-networks-for-precision-oncology-promises-and-pitfalls
#4
REVIEW
John Paul Shen, Trey Ideker
Synthetic lethal interactions, in which the simultaneous loss-of-function of two genes produces a lethal phenotype, are being explored as a means to therapeutically exploit cancer-specific vulnerabilities and expand the scope of precision oncology. Currently, three FDA approved drugs work by targeting the synthetic lethal interaction between BRCA1/2 and PARP. This review examines additional efforts to discover networks of synthetic lethal interactions and discusses both challenges and opportunities regarding the translation of new synthetic lethal interactions into the clinic...
June 19, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29932613/human-subject-protection-acceptance-of-data-from-clinical-investigations-for-medical-devices-final-rule
#5
(no author information available yet)
The Food and Drug Administration (FDA or we) is amending its regulations on acceptance of data from clinical investigations for medical devices. We are requiring that data submitted from clinical investigations conducted outside the United States intended to support an investigational device exemption (IDE) application, a premarket notification (510(k)) submission, a request for De Novo classification, a premarket approval (PMA) application, a product development protocol (PDP) application, or a humanitarian device exemption (HDE) application be from investigations conducted in accordance with good clinical practice (GCP), which includes obtaining and documenting the review and approval of the clinical investigation by an independent ethics committee (IEC) and obtaining and documenting freely given informed consent of subjects, which includes individuals whose specimens are used in investigations of medical devices...
February 21, 2018: Federal Register
https://www.readbyqxmd.com/read/29932115/a-method-for-developing-rapid-screening-values-for-active-pharmaceutical-ingredients-apis-in-water-and-results-of-initial-application-for-119-apis
#6
Ashley Suchomel, Helen Goeden, Julia Dady
Americans fill upward of four billion prescriptions for pharmaceuticals each year, and many of those pharmaceuticals eventually make their way into the environment. Hundreds of different active pharmaceutical ingredients (APIs) are detected in ambient waters and source water used for drinking water in the U.S. Very few of these drugs have health-based guidance values that suggest a safe level for individuals exposed in the ambient environment through drinking water. The Minnesota Department of Health (MDH) has developed a novel method to derive screening-level human health guidance values for APIs...
June 22, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29931526/an-up-to-date-catalog-of-available-urinary-biomarkers-for-the-surveillance-of-non-muscle-invasive-bladder-cancer
#7
REVIEW
Francesco Soria, Michael J Droller, Yair Lotan, Paolo Gontero, David D'Andrea, Kilian M Gust, Morgan Rouprêt, Marek Babjuk, Joan Palou, Shahrokh F Shariat
OBJECTIVES: With the advent of novel genomic and transcriptomic technologies, new urinary biomarkers have been identified and tested for bladder cancer (BCa) surveillance. To summarize the current status of urinary biomarkers for the detection of recurrence and/or progression in the follow-up of non-muscle invasive BCa patients, and to assess the value of urinary biomarkers in predicting response to intravesical Bacillus Calmette-Guerin (BCG) therapy. METHODS AND MATERIALS: A medline/pubmed© literature search was performed...
June 21, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29930804/potential-candidate-treatment-agents-for-targeting-of-cholangiocarcinoma-identified-by-gene-expression-profile-analysis
#8
Suthipong Chujan, Tawit Suriyo, Teerapat Ungtrakul, Yotsawat Pomyen, Jutamaad Satayavivad
Cholangiocarcinoma (CCA) remains to be a major health problem in several Asian countries including Thailand. The molecular mechanism of CCA is poorly understood. Early diagnosis is difficult, and at present, no effective therapeutic drug is available. The present study aimed to identify the molecular mechanism of CCA by gene expression profile analysis and to search for current approved drugs which may interact with the upregulated genes in CCA. Gene Expression Omnibus (GEO) was used to analyze the gene expression profiles of CCA patients and normal subjects...
July 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29930727/a-tightly-controlled-src-yap-signaling-axis-determines-therapeutic-response-to-dasatinib-in-renal-cell-carcinoma
#9
Jingya Sun, Xin Wang, Boyun Tang, Hongchun Liu, Minmin Zhang, Yueqin Wang, Fangfang Ping, Jian Ding, Aijun Shen, Meiyu Geng
Over the past decade, therapies targeting the VEGF/VEGFR and mTOR pathways have served as the standard of care for the clinical management of renal cell carcinoma (RCC) patients. Albeit promising, these targeted drugs have attained only modest clinical benefits with limited prolonged progression-free survival. Therefore, alternative reasonable and applicable therapeutic approaches should be introduced to improve the clinical outcome of RCC patients. Methods: FDA approved kinase inhibitors were screened to evaluate their abilities to suppress the proliferation of RCC cells...
2018: Theranostics
https://www.readbyqxmd.com/read/29928134/reformulating-acute-myeloid-leukemia-liposomal-cytarabine-and-daunorubicin-cpx-351-as-an-emerging-therapy-for-secondary-aml
#10
REVIEW
Evan C Chen, Amir T Fathi, Andrew M Brunner
Despite increasing understanding of the pathobiology of acute myeloid leukemia (AML), outcomes remain dismal particularly for patients over the age of 60 years, a population enriched for therapy-related AML (tAML) and secondary AML (sAML). For decades, the standard of care for AML has been the combination of cytarabine and daunorubicin, typically delivered in combination as "7 + 3" induction. In 2017, a liposomal-encapsulated combination of daunorubicin and cytarabine (CPX-351, Vyxeos) was approved by the US Food and Drug Administration (FDA) for use in the treatment of newly diagnosed tAML or AML with myelodysplasia-related changes (AML-MRCs)...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29927691/a-survey-of-payer-perspectives-on-cannabis-use-disorder
#11
Andrew M Kiselica, Amy Duhig, Ivan Montoya, Phil Skolnick, Jennifer Floyd, Cigi Byars
BACKGROUND: Cannabis use disorder (CUD) as described/defined in DSM 5, is characterized by impaired control of marijuana use and related personal, health, and legal consequences. CUD is a serious public health problem, affecting nearly 6 million individuals in the United States. There are no FDA approved medications to treat this disorder. The lack of available treatment options contributes to uncertainties by drug sponsors about formulary and reimbursement decision-making for CUD pharmacotherapies...
June 21, 2018: Substance Use & Misuse
https://www.readbyqxmd.com/read/29926506/recent-developments-in-heterocycles-labeling-with-carbon-isotopes
#12
Antonio Del Vecchio, Gianluca Destro, Frédéric Taran, Davide Audisio
Heterocycles play an essential role in modern pharmaceutical and agrochemical developments, representing a very common structural unit in marketed drugs. Over the 46 new drugs approved in 2017 by the FDA, 25 contain in their structure an heterocyclic core. The development of novel and straightforward labeling strategies for the effective insertion of carbon isotopes into heterocylic scaffolds is an inspiring and vibrant field of research. The use of carbon-11, carbon-13 and carbon-14 isotopes is well established in life science and particularly in pharmaceutical and agrochemical industry...
June 20, 2018: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/29925527/identification-of-fda-approved-oncology-drugs-with-selective-potency-in-high-risk-childhood-ependymoma
#13
Andrew M Donson, Vladimir Amani, Elliot A Warner, Andrea M Griesinger, Davis A Witt, Jean M Mulcahy Levy, Lindsey M Hoffman, Todd C Hankinson, Michael H Handler, Rajeev Vibhakar, Kathleen Dorris, Nicholas K Foreman
Children with ependymoma are cured in less than 50% of cases, with little improvement in outcome over the last several decades. Chemotherapy has not impacted survival in ependymoma, due in part to a lack of preclinical models that has precluded comprehensive drug testing. We recently developed two human ependymoma cell lines harboring high-risk phenotypes which provided us with an opportunity to execute translational studies. ependymoma and other pediatric brain tumor cell lines were subject to a large-scale comparative drug screen of ependymoma -approved oncology drugs for rapid clinical application...
June 20, 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29923810/novel-therapies-for-sleep-apnea-the-implants-have-arrived
#14
Edwin M Valladares, Terese C Hammond
Positive airway pressure (PAP) therapy has been the standard treatment of choice for sleep disordered breathing, with 29-83% of patients being noncompliant. With the advent of newly Food and Drug Adminisatration (FDA)-approved implantable stimulators for treating sleep disordered breathing in a fraction of noncompliant PAP therapy patients, the landscape of sleep medicine and sleep technology is changing to narrow the gap between compliant and non-compliant patients. The remedē® System for treating central sleep apnea and the Inspire® upper airway stimulation (UAS) therapy for treating obstructive sleep apnea are providing new tools for sleep physicians, elevating sleep technologists' expertise, and paving the way for personalized medicine...
2018: Neurodiagnostic Journal
https://www.readbyqxmd.com/read/29922850/safety-of-orogastric-tubes-in-foregut-and-bariatric-surgery
#15
Kulvir Nandra, Richard Ing
BACKGROUND: Orogastric tubes have traditionally aided foregut procedures with sizing and organ protection. The rise of bariatric surgery has led to the creation of novel medical devices aimed at facilitating the laparoscopic sleeve gastrectomy. While approved by the FDA, the long-term safety profile of these devices in the general population is often unknown. This review looks at complications associated with novel Orogastric Tubes compared to the traditional bougie. METHODS: We performed a review of the Food and Drug Administration's (FDA) Manufacturer and User Facility Device Experience (MAUDE) database for complications associated with the traditional bougie, Boehringer Labs ViSiGi 3D® and the Medtronic GastriSail™ since 2011...
June 19, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29922160/decost-a-new-approach-in-drug-repurposing-from-control-system-theory
#16
Thanh M Nguyen, Syed A Muhammad, Sara Ibrahim, Lin Ma, Jinlei Guo, Baogang Bai, Bixin Zeng
In this paper, we propose DeCoST (Drug Repurposing from Control System Theory) framework to apply control system paradigm for drug repurposing purpose. Drug repurposing has become one of the most active areas in pharmacology since the last decade. Compared to traditional drug development, drug repurposing may provide more systematic and significantly less expensive approaches in discovering new treatments for complex diseases. Although drug repurposing techniques rapidly evolve from "one: disease-gene-drug" to "multi: gene, dru" and from "lazy guilt-by-association" to "systematic model-based pattern matching," mathematical system and control paradigm has not been widely applied to model the system biology connectivity among drugs, genes, and diseases...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29921948/increased-sensitivity-to-apoptosis-upon-endoplasmic-reticulum-stress-induced-activation-of-the-unfolded-protein-response-in-chemotherapy-resistant-malignant-pleural-mesothelioma
#17
Duo Xu, Shun-Qing Liang, Haitang Yang, Ursina Lüthi, Carsten Riether, Sabina Berezowska, Thomas M Marti, Sean R R Hall, Rémy Bruggmann, Gregor J Kocher, Ralph A Schmid, Ren-Wang Peng
BACKGROUND: Standard treatment for advanced malignant pleural mesothelioma (MPM) is a cisplatin/pemetrexed (MTA) regimen; however, this is confronted by drug resistance. Proteotoxic stress in the endoplasmic reticulum (ER) is a hallmark of cancer and some rely on this stress signalling in response to cytotoxic chemotherapeutics. We hypothesise that ER stress and the adaptive unfolded protein response (UPR) play a role in chemotherapy resistance of MPM. METHODS: In vitro three-dimensional (3D) and ex vivo organotypic culture were used to enrich a chemotherapy-resistant population and recapitulate an in vivo MPM microenvironment, respectively...
June 20, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29915537/preclinical-animal-models-for-dravet-syndrome-seizure-phenotypes-comorbidities-and-drug-screening
#18
REVIEW
Aliesha Griffin, Kyla R Hamling, SoonGweon Hong, Mana Anvar, Luke P Lee, Scott C Baraban
Epilepsy is a common chronic neurological disease affecting almost 3 million people in the United States and 50 million people worldwide. Despite availability of more than two dozen FDA-approved anti-epileptic drugs (AEDs), one-third of patients fail to receive adequate seizure control. Specifically, pediatric genetic epilepsies are often the most severe, debilitating and pharmaco-resistant forms of epilepsy. Epileptic syndromes share a common symptom of unprovoked seizures. While some epilepsies/forms of epilepsy are the result of acquired insults such as head trauma, febrile seizure, or viral infection, others have a genetic basis...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29915255/priapism-caused-by-rhino-7-platinum-3000-an-over-the-counter-male-enhancement-supplement
#19
Harsha R Mittakanti, Christopher S Elliott
Male enhancement and erectile dysfunction supplements are typically non-Food and Drug Administration (FDA) approved and readily available for purchase by anyone. Longstanding priapism is a significant potential side effect. A 25-year-old man presented with a 48-h priapism after taking Rhino 7 Platinum 3000. He required bilateral corpo-glanular shunting to alleviate his priapism. On initial 2-week follow-up, he had significant fibrosis of the corporal bodies bilaterally and had been unable to achieve an erection...
June 19, 2018: International Journal of Impotence Research
https://www.readbyqxmd.com/read/29913906/using-fmri-to-evaluate-the-effects-of-milnacipran-on-central-pain-processing-in-patients-with-fibromyalgia
#20
F Petzke, K B Jensen, E Kosek, E Choy, S Carville, P Fransson, S C R Williams, H Marcus, Y Mainguy, M Ingvar, R H Gracely
Background In recent years, the prescription of serotonin-noradrenalin reuptake inhibitors (SNRIs) for treatment of fibromyalgia (FM) has increased with reports of their efficacy. The SNRI milnacipran is approved by the U.S. Food and Drug Administration (FDA) for treatment of FM, yet, the mechanisms by which milnacipran reduces FM symptoms are unknown. A large number of neuroimaging studies have demonstrated altered brain function in patients with FM but the effect of milnacipran on central pain processing has not been investigated...
December 29, 2017: Scandinavian Journal of Pain
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