keyword
MENU ▼
Read by QxMD icon Read
search

Farber

keyword
https://www.readbyqxmd.com/read/29151166/t2-weighted-images-are-superior-to-other-mr-image-types-for-the-determination-of-diffuse-intrinsic-pontine-glioma-intratumoral-heterogeneity
#1
Stephen Harward, S Harrison Farber, Michael Malinzak, Oren Becher, Eric M Thompson
PURPOSE: Diffuse intrinsic pontine glioma (DIPG) remains the main cause of death in children with brain tumors. Given the inefficacy of numerous peripherally delivered agents to treat DIPG, convection enhanced delivery (CED) of therapeutic agents is a promising treatment modality. The purpose of this study was to determine which MR imaging type provides the best discrimination of intratumoral heterogeneity to guide future stereotactic implantation of CED catheters into the most cellular tumor regions...
November 18, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29140589/simple-access-to-the-heaviest-alkaline-earth-metal-hydride-a-strongly-reducing-hydrocarbon-soluble-barium-hydride-cluster
#2
Sjoerd Harder, Brant Maitland, Michael Wiesinger, Christian Färber, Gerd Ballmann, Holger Elsen, Christian Fischer
Reaction of Ba[N(SiMe3)2]2 with PhSiH3 in toluene gave simple access to the unique Ba hydride cluster Ba7H7[N(SiMe3)2]7 that can be described as a square pyramide spanned by five Ba2+ ions with two flanking BaH[N(SiMe3)2] units. This heptanuclear cluster is well soluble in aromatic solvents and the hydride 1H NMR signals and coupling pattern suggests that the structure is stable in solution. At 95 °C, no coalescence of hydride signals is observed but the cluster slowly decomposes to undefined Ba hydride species...
November 15, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29140104/corrective-statements-from-the-tobacco-industry-more-evidence-for-why-we-need-effective-tobacco-control
#3
Harold J Farber, Enid R Neptune, Gary W Ewart
No abstract text is available yet for this article.
November 15, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29137232/integration-of-metabolomics-transcriptomics-and-microrna-expression-profiling-reveals-a-mir-143-hk2-glucose-network-underlying-zinc-deficiency-associated-esophageal-neoplasia
#4
Louise Y Fong, Ruiyan Jing, Karl J Smalley, Cristian Taccioli, Johannes Fahrmann, Dinesh K Barupal, Hansjuerg Alder, John L Farber, Oliver Fiehn, Carlo M Croce
Esophageal squamous cell carcinoma (ESCC) in humans is a deadly disease associated with dietary zinc (Zn)-deficiency. In the rat esophagus, Zn-deficiency induces cell proliferation, alters mRNA and microRNA gene expression, and promotes ESCC. We investigated whether Zn-deficiency alters cell metabolism by evaluating metabolomic profiles of esophageal epithelia from Zn-deficient and replenished rats vs sufficient rats, using untargeted gas chromatography time-of-flight mass spectrometry (n = 8/group). The Zn-deficient proliferative esophagus exhibits a distinct metabolic profile with glucose down 153-fold and lactic acid up 1...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29126684/a-tale-of-three-surgeries-management-of-a-massive-recurrent-mycotic-aortic-pseudoaneurysm
#5
Megan D Henley, Mark A Farber, John S Ikonomidis, Lavinia M Kolarczyk, Emily G Teeter, Brian P Barrick, Thomas G Caranasos, Susan M Martinelli
No abstract text is available yet for this article.
August 26, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29123016/the-use-of-hyperbaric-oxygen-for-the-prevention-and-management-of-osteoradionecrosis-of-the-jaw-a-dana-farber-brigham-and-women-s-cancer-center-multidisciplinary-guideline
#6
Ahmed Sultan, Glenn J Hanna, Danielle N Margalit, Nicole Chau, Laura A Goguen, Francisco M Marty, Guilherme Rabinowits, Jonathan D Schoenfeld, Stephen T Sonis, Tom Thomas, Roy B Tishler, Nathaniel S Treister, Alessandro Villa, Sook-Bin Woo, Robert Haddad, Hani Mawardi
No abstract text is available yet for this article.
November 2017: Oncologist
https://www.readbyqxmd.com/read/29121844/patient-and-aneurysm-characteristics-predicting-prolonged-length-of-stay-after-elective-open-aaa-repair-in-the-endovascular-era
#7
Sergio Casillas-Berumen, Florencia A Rojas-Miguez, Alik Farber, Sevan Komshian, Jeffrey A Kalish, Denis Rybin, Gheorghe Doros, Jeffrey J Siracuse
INTRODUCTION: Open aortic aneurysm repair (AAA) repair can be resource intensive and associated with a prolonged length of stay (LOS). We sought to examine patient and aneurysm predictors of prolonged LOS to better identify those at risk in the preoperative setting. METHODS: Patient data were obtained from the targeted AAA American College of Surgery National Surgical Quality Improvement Program database from 2012 to 2014 of patients undergoing open AAA repair. Multivariable logistic regression was used to determine predictors of prolonged postoperative LOS defined as greater than 10 days (75th percentile)...
January 1, 2017: Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29100876/preoperative-antiplatelet-and-statin-use-does-not-affect-outcomes-after-carotid-endarterectomy
#8
Brianna M Krafcik, Alik Farber, Robert T Eberhardt, Jeffrey A Kalish, Denis Rybin, Gheorghe Doros, Steven L Pike, Jeffrey J Siracuse
OBJECTIVE: The use of statin and antiplatelet medications has been advocated in patients with cerebrovascular disease as primary medical therapy and as an adjunct to carotid endarterectomy (CEA). Our goal was to assess the prevalence of preoperative statin and antiplatelet use and its effect on perioperative outcomes after CEA. METHODS: The American College of Surgeons National Surgical Quality Improvement Program targeted CEA database was queried for patients undergoing CEA between 2011 and 2014...
October 31, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29098284/association-of-alterations-in-main-driver-genes-with-outcomes-of-patients-with-resected-pancreatic-ductal-adenocarcinoma
#9
Zhi Rong Qian, Douglas A Rubinson, Jonathan A Nowak, Vicente Morales-Oyarvide, Richard F Dunne, Margaret M Kozak, Marisa W Welch, Lauren K Brais, Annacarolina Da Silva, Tingting Li, Wanwan Li, Atsuhiro Masuda, Juhong Yang, Yan Shi, Mancang Gu, Yohei Masugi, Justin Bui, Caitlin L Zellers, Chen Yuan, Ana Babic, Natalia Khalaf, Andrew Aguirre, Kimmie Ng, Rebecca A Miksad, Andrea J Bullock, Daniel T Chang, Jennifer F Tseng, Thomas E Clancy, David C Linehan, Jennifer J Findeis-Hosey, Leona A Doyle, Aaron R Thorner, Matthew Ducar, Bruce Wollison, Angelica Laing, William C Hahn, Matthew Meyerson, Charles S Fuchs, Shuji Ogino, Jason L Hornick, Aram F Hezel, Albert C Koong, Brian M Wolpin
Importance: Although patients with resected pancreatic adenocarcinoma are at high risk for disease recurrence, few biomarkers are available to inform patient outcomes. Objective: To evaluate the alterations of the 4 main driver genes in pancreatic adenocarcinoma and patient outcomes after cancer resection. Design, Setting, and Participants: This study analyzed protein expression and DNA alterations for the KRAS, CDKN2A, SMAD4, and TP53 genes by immunohistochemistry and next-generation sequencing in formalin-fixed, paraffin-embedded tumors in 356 patients with resected pancreatic adenocarcinoma who were treated at the Dana-Farber/Brigham and Women's Cancer Center (October 26, 2002, to May 21, 2012), University of Rochester Medical Center (March 1, 2006, to November 1, 2013), or Stanford Cancer Institute (September 26, 1995, to May 22, 2013)...
November 2, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/29096938/temporary-treatment-interruptions-with-oral-selexipag-in-pulmonary-arterial-hypertension-insights-from-the-prostacyclin-pgi2-receptor-agonist-in-pulmonary-arterial-hypertension-griphon-study
#10
Ioana R Preston, Richard N Channick, Kelly Chin, Lilla Di Scala, Harrison W Farber, Sean Gaine, Nazzareno Galiè, Hossein-Ardeschir Ghofrani, Marius M Hoeper, Irene M Lang, Vallerie V McLaughlin, Ralph Preiss, Gérald Simonneau, Olivier Sitbon, Victor F Tapson, Lewis J Rubin
BACKGROUND: Parenteral prostacyclin analogs that target the prostacyclin pathway have been used to treat pulmonary arterial hypertension (PAH) since the 1990s. Abrupt discontinuation of parenteral prostacyclin analogs can be associated with acute deterioration of PAH. Less is known about temporary interruption of oral therapies that target the prostacyclin pathway, such as selexipag. METHODS: We evaluated the frequency, duration, reasons, and consequences of temporary selexipag interruptions among PAH patients enrolled in the Prostacyclin (PGI2) Receptor Agonist in Pulmonary Arterial Hypertension (GRIPHON) study...
October 2, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29090520/an-investigation-of-toxicities-and-survival-in-hispanic-children-and-adolescents-with-all-results-from-the-dana-farber-cancer-institute-all-consortium-protocol-05-001
#11
Justine M Kahn, Peter D Cole, Traci M Blonquist, Kristen Stevenson, Zhezhen Jin, Sergio Barrera, Randy Davila, Emily Roberts, Donna S Neuberg, Uma H Athale, Luis A Clavell, Caroline Laverdiere, Jean-Marie Leclerc, Bruno Michon, Marshall A Schorin, Jennifer J G Welch, Stephen E Sallan, Lewis B Silverman, Kara M Kelly
PURPOSE: This study compared the relative incidence of treatment-related toxicities and the event-free and overall survival between Hispanic and non-Hispanic children undergoing therapy for acute lymphoblastic leukemia (ALL) on Dana-Farber Cancer Institute ALL Consortium protocol 05-001. PATIENTS AND METHODS: Secondary analysis of prospectively collected data from a phase III multicenter study in children and adolescents of 1-18 years with previously untreated ALL...
November 1, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29071338/prognostic-effect-and-longitudinal-hemodynamic-assessment-of-borderline-pulmonary-hypertension
#12
Tufik R Assad, Bradley A Maron, Ivan M Robbins, Meng Xu, Shi Huang, Frank E Harrell, Eric H Farber-Eger, Quinn S Wells, Gaurav Choudhary, Anna R Hemnes, Evan L Brittain
Importance: Pulmonary hypertension (PH) is diagnosed by a mean pulmonary arterial pressure (mPAP) value of at least 25 mm Hg during right heart catheterization (RHC). While several studies have demonstrated increased mortality in patients with mPAP less than that threshold, little is known about the natural history of borderline PH. Objective: To test the hypothesis that patients with borderline PH have decreased survival compared with patients with lower mPAP and frequently develop overt PH and to identify clinical correlates of borderline PH...
October 25, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/29066557/neuromedin-b-expression-defines-the-mouse-retrotrapezoid-nucleus
#13
Yingtang Shi, Ruth L Stornetta, Daniel S Stornetta, Suna Onengut-Gumuscu, Emily A Farber, Stephen D Turner, Patrice G Guyenet, Douglas A Bayliss
The retrotrapezoid nucleus (RTN) consists, by definition, of Phox2b-expressing, glutamatergic, non-catecholaminergic, non-cholinergic neurons located in the parafacial region of the medulla oblongata. An unknown proportion of RTN neurons are central respiratory chemoreceptors and there is mounting evidence for biochemical diversity among these cells. Here, we used multiplexed in situ hybridization and single-cell RNA-Seq in male and female mice to provide a more comprehensive view of the phenotypic diversity of RTN neurons...
October 24, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29060525/arfi-variance-of-acceleration-voa-for-noninvasive-characterization-of-human-carotid-plaques-in-vivo
#14
Gabriela Torres, Tomasz J Czernuszewicz, Jonathon W Homeister, Mark A Farber, Caterina M Gallippi
Rather than degree of stenosis, assessing plaque structure and composition is relevant to discerning risk for plaque rupture with downstream ischemic event. The structure and composition of carotid plaque has been assessed noninvasively using Acoustic Radiation Force Impulse (ARFI) ultrasound imaging. In particular, ARFI-derived peak displacement (PD) estimations have been demonstrated for discriminating soft (lipid rich necrotic core (LRNC) or intraplaque hemorrhage (IPH)) from stiff (collagen (COL) or calcium (CAL)) plaque features; however, PD did not differentiate LRNC from IPH or COL from CAL...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29049492/association-of-hsd3b1-genotype-with-response-to-androgen-deprivation-therapy-for-biochemical-recurrence-after-radiotherapy-for-localized-prostate-cancer
#15
Jason W D Hearn, Wanling Xie, Mari Nakabayashi, Nima Almassi, Chad A Reichard, Mark Pomerantz, Philip W Kantoff, Nima Sharifi
Importance: The variant HSD3B1 (1245C) allele enhances dihydrotestosterone synthesis and predicts resistance to androgen-deprivation therapy (ADT) for biochemically recurrent prostate cancer after prostatectomy and for metastatic disease. Whether this is true after radiotherapy is unknown. Objective: To determine whether the HSD3B1 (1245C) allele predicts worse clinical outcomes from ADT for biochemical recurrence after radiotherapy. Design, Setting, and Participants: The Prostate Clinical Research Information System at Dana-Farber Cancer Institute was used to identify the study cohort, which included men treated with ADT for biochemical recurrence after primary radiotherapy between 1996 and 2013...
October 12, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/29048594/neptune-a-bioinformatics-tool-for-rapid-discovery-of-genomic-variation-in-bacterial-populations
#16
Eric Marinier, Rahat Zaheer, Chrystal Berry, Kelly A Weedmark, Michael Domaratzki, Philip Mabon, Natalie C Knox, Aleisha R Reimer, Morag R Graham, Linda Chui, Laura Patterson-Fortin, Jian Zhang, Franco Pagotto, Jeff Farber, Jim Mahony, Karine Seyer, Sadjia Bekal, Cécile Tremblay, Judy Isaac-Renton, Natalie Prystajecky, Jessica Chen, Peter Slade, Gary Van Domselaar
The ready availability of vast amounts of genomic sequence data has created the need to rethink comparative genomics algorithms using 'big data' approaches. Neptune is an efficient system for rapidly locating differentially abundant genomic content in bacterial populations using an exact k-mer matching strategy, while accommodating k-mer mismatches. Neptune's loci discovery process identifies sequences that are sufficiently common to a group of target sequences and sufficiently absent from non-targets using probabilistic models...
October 13, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29048419/a-cross-sectional-quantitative-analysis-of-the-natural-history-of-farber-disease-an-ultra-orphan-condition-with-rheumatologic-and-neurological-cardinal-disease-features
#17
Matthias Zielonka, Sven F Garbade, Stefan Kölker, Georg F Hoffmann, Markus Ries
PurposeFarber disease (OMIM 22800) is an ultrarare progressive multisystemic neurodevelopmental storage disorder caused by a deficiency of the lysosomal enzyme acid ceramidase (AC). Hard clinical end points for future clinical trials remain to be defined.MethodsWe quantitatively analyzed published cases with Farber disease (N = 96). The main outcome variables were survival and diagnostic delay. As a potential predictor of survival, the influence of residual AC enzyme activity was investigated. The analysis was performed in compliance with STROBE criteria...
October 19, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29044601/let-s-not-talk-about-sex
#18
Melanie Love, Barry A Farber
This article uses both a case illustration and data from a large-scale survey of outpatient clients (N = 798) to understand the client's perspective about avoiding or being dishonest with his or her therapist about sexual topics. The case study, of a gay young man working with a heterosexual female therapist, explores this client's experience of what happens when it feels impossible to be forthcoming about sex and sexuality. Based on the findings of our study, we note clients' motives for avoiding these intimate yet important areas (e...
November 2017: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/29042076/perioperative-outcomes-after-reoperative-carotid-endarterectomy-are-worse-than-expected
#19
Brianna M Krafcik, Thomas W Cheng, Alik Farber, Jeffrey A Kalish, Denis Rybin, Gheorghe Doros, Jeffrey J Siracuse
OBJECTIVE: Reoperative carotid endarterectomy (CEA) can be technically challenging because of significant scarring as a consequence of the initial CEA procedure. There are limited data that describe outcomes after reoperative CEA, and as such, our goal was to determine the effect of reoperative CEA on perioperative outcomes. METHODS: The American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) database was queried for patients undergoing index and reoperative CEA between 2005 and 2014...
October 14, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29031841/management-of-post-radical-prostatectomy-urinary-incontinence-a-review
#20
REVIEW
Kushan D Radadia, Nicholas J Farber, Brian Shinder, Charles F Polotti, Lee J Milas, Hari Tunuguntla
Post-prostatectomy urinary incontinence (PPUI) has significant impact on the quality of life of patients who undergo radical prostatectomy. Stress and overflow incontinence may result from the procedure, with sphincteric incompetence and detrusor hypocontractility implicating their development, respectively. In many cases, treatment begins with conservative approaches, including pelvic floor muscle training/biofeedback. Pharmacotherapy can be used to treat overactive bladder. For stress incontinence, transurethral bulking agents are utilized in select patients, however AUS and male slings are the most efficacious options with good success rates...
October 11, 2017: Urology
keyword
keyword
73787
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"