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JOURNAL ARTICLE
Xuemei Wang, Yuan Ma, Jing Ru, Lin Fan, Rao Peng, Xinzhen Du, Xiaoquan Lu
Pharmaceuticals and personal care products (PPCPs) have a significant impact on the environment and human health, due to their sometimes toxic and carcinogenic characteristics. Therefore, an innovative chemosensor was constructed for ultrasensitive determination of two typical PCCPs (hydroquinone (HQ) and catechol (CC)) in several minutes. The homemade chemosensor (UiO-67@GO/MWCNTs) consisted of MOF(UiO-67), graphene oxide (GO), and multi-walled carbon nanotubes (MWCNTs) composites; it was a networked, structurally sparse, porosity-rich, homogeneous octahedral composite, and had ultra-high electrical conductivity, which provided lots of active adsorption sites, promote charge transfer, and enrich lots of molecules to be measured in a few minutes...
April 18, 2024: Mikrochimica Acta
#22
JOURNAL ARTICLE
Tissue specific tumor-gene link prediction through sampling based GNN using a heterogeneous network.
Surabhi Mishra, Gurjot Singh, Mahua Bhattacharya
A tissue sample is a valuable resource for understanding a patient's symptoms and health status in relation to tumor growth. Recent research seeks to establish a connection between tissue-specific tumor samples and genetic markers (genes). This breakthrough has paved the way for personalized cancer therapies. With this motivation, the proposed model constructs a heterogeneous network based on tumor sample-gene relation data and gene-gene interaction data. This network also incorporates tissue-specific gene expression and primary site-based gene counts as features, enabling tissue-specific predictions...
April 18, 2024: Medical & Biological Engineering & Computing
#23
JOURNAL ARTICLE
Fei Miao, Cheng Cheng, Wei Ren, Hui Zhang, Shaobin Wang, Xiaoguang Duan
Peracetic acid (PAA) oxidation catalyzed by metal-free carbons is promising for advanced water decontamination. Nevertheless, developing reaction-oriented and high-performance carbocatalysts has been limited by the ambiguous understanding of the intrinsic relationship between carbon chemical/molecular structure and PAA transformation behavior. Herein, we comprehensively investigated the PAA activation using a family of well-defined sp2 /sp3 carbon hybrids from annealed nanodiamonds (ANDs). The activity of ANDs displays a volcano-type trend, with respect to the sp2 /sp3 ratio...
April 18, 2024: Environmental Science & Technology
#24
JOURNAL ARTICLE
Yoo Min Han, Jeong Hee Yoon, Seokha Yoo, Su Jin Chung, Jeong Min Lee, Ji Min Choi, Eun Hyo Jin, Ji Yeon Seo
BACKGROUND AND AIMS: Visceral obesity is a risk factor for reflux esophagitis (RE). We investigated the risk of RE according to visceral adipose tissue (VAT) measured by deep neural network architecture using computed tomography and evaluated the longitudinal association between abdominal adipose tissue changes and the disease course of RE. METHODS: Individuals receiving health checkups who underwent esophagogastroduodenoscopy (EGD) and abdominal computed tomography (CT) at Seoul National University Healthcare System Gangnam Center between 2015 and 2016 were included...
April 18, 2024: American Journal of Gastroenterology
#25
Karen Spilsbury, Andy Charlwood, Carl Thompson, Kirsty Haunch, Danat Valizade, Reena Devi, Cornell Jackson, David Phillip Alldred, Antony Arthur, Lucy Brown, Paul Edwards, Will Fenton, Heather Gage, Matthew Glover, Barbara Hanratty, Julienne Meyer, Aileen Waton
BACKGROUND: Quality of life and care varies between and within the care homes in which almost half a million older people live and over half a million direct care staff (registered nurses and care assistants) work. The reasons are complex, understudied and sometimes oversimplified, but staff and their work are a significant influence. OBJECTIVE(S): To explore variations in the care home nursing and support workforce; how resident and relatives' needs in care homes are linked to care home staffing; how different staffing models impact on care quality, outcomes and costs; how workforce numbers, skill mix and stability meet residents' needs; the contributions of the care home workforce to enhancing quality of care; staff relationships as a platform for implementation by providers...
April 2024: Health Soc Care Deliv Res
#26
JOURNAL ARTICLE
Divya Parmar, Semira Berhe, Susan Bradley, Ama Fenny, Lydia Aziato, Haddijatou Ceesay
Nearly 31% of the Ghanaian population are adolescents, and these populations persistently face high rates of teenage pregnancies and unsafe abortions. This is despite sexual and reproductive health (SRH) being taught in the school curriculum. In this qualitative study, we explore the factors affecting adolescents' access to, and experiences of, SRH services in Accra, Ghana. We conducted 12 focus group discussions (FGDs) with adolescents and 13 key informant interviews (KIs) in Ghana. The FGDs were conducted with school-going and out-of-school adolescents...
January 2024: Global Public Health
#27
JOURNAL ARTICLE
Tengyu Weng, Xiaoning Zhang, Juan He, Yi Yang, Chengxin Li
BACKGROUND: Ultraviolet radiation causes skin photoaging by producing a variety of enzymes, which impact both skin health and hinder beauty. Currently, the early diagnosis and treatment of photoaging remain a challenge. Bioinformatics analysis has strong advantages in exploring core genes and the biological pathways of photoaging. AIMS: To screen and validate key risk genes associated with plasminogen in photoaging and to identify potential target genes for photoaging...
April 17, 2024: Journal of Cosmetic Dermatology
#28
REVIEW
Benancio N Rodriguez, Helen Huang, Jennifer J Chia, Alexander Hoffmann
The noncanonical NFκB signaling pathway mediates the biological functions of diverse cell survival, growth, maturation, and differentiation factors that are important for the development and maintenance of hematopoietic cells and immune organs. Its dysregulation is associated with a number of immune pathologies and malignancies. Originally described as the signaling pathway that controls the NFκB family member RelB, we now know that noncanonical signaling also controls NFκB RelA and cRel. Here, we aim to clarify our understanding of the molecular network that mediates noncanonical NFκB signaling and review the human diseases that result from a deficient or hyper-active noncanonical NFκB pathway...
April 18, 2024: WIREs Mech Dis
#29
JOURNAL ARTICLE
Haewon Byeon, Mohannad Al-Kubaisi, Ashit Kumar Dutta, Faisal Alghayadh, Mukesh Soni, Manisha Bhende, Venkata Chunduri, K Suresh Babu, Rubal Jeet
According to experts in neurology, brain tumours pose a serious risk to human health. The clinical identification and treatment of brain tumours rely heavily on accurate segmentation. The varied sizes, forms, and locations of brain tumours make accurate automated segmentation a formidable obstacle in the field of neuroscience. U-Net, with its computational intelligence and concise design, has lately been the go-to model for fixing medical picture segmentation issues. Problems with restricted local receptive fields, lost spatial information, and inadequate contextual information are still plaguing artificial intelligence...
2024: Frontiers in Computational Neuroscience
#30
JOURNAL ARTICLE
Carlotta Fiammenghi, Loredana Covolo, Anna Vanoncini, Umberto Gelatti, Elisabetta Ceretti
INTRODUCTION: Hospitals play a potentially crucial role in public health, and social media can be powerful tools to reach their target audiences but are hospitals exploiting them to their full potential? METHODS: We retrieved the institutional webpages and the social media profiles (Facebook, Instagram, X (Twitter), YouTube, LinkedIn, WhatsApp and Telegram) of all Italian public hospitals located in regional capitals ( N = 194). From 1 March to 30 April 2022, we analysed these profiles, noting the number of followers and of posts published, the date of the last post, and the availability of a social media policy...
2024: Digital Health
#31
JOURNAL ARTICLE
Satya P Singh, Sukrit Gupta, Jagath C Rajapakse
Brain state classification by applying deep learning techniques on neuroimaging data has become a recent topic of research. However, unlike domains where the data is low dimensional or there are large number of available training samples, neuroimaging data is high dimensional and has few training samples. To tackle these issues, we present a sparse feedforward deep neural architecture for encoding and decoding the structural connectome of the human brain. We use a sparsely connected element-wise multiplication as the first hidden layer and a fixed transform layer as the output layer...
2024: IEEE Journal of Translational Engineering in Health and Medicine
#32
JOURNAL ARTICLE
Indrajit Kalita, Andreas Kamilaris, Paul Havinga, Igor Reva
This study provides a comprehensive investigation of the impact of disinfection byproducts (DBPs) on human health, with a particular focus on DBPs present in chlorinated drinking water, concentrating on three primary DBP categories (aliphatic, alicyclic, and aromatic). Additionally, it explores pivotal factors influencing DBP formation, encompassing disinfectant types, water source characteristics, and environmental conditions, such as the presence of natural materials in water. The main objective is to discern the most hazardous DBPs, considering criteria such as regulation standards, potential health impacts, and chemical diversity...
April 12, 2024: ACS ES&T water
#33
JOURNAL ARTICLE
Wei Liu, Kebin Jia, Zhuozheng Wang
Depression has become the prevailing global mental health concern. The accuracy of traditional depression diagnosis methods faces challenges due to diverse factors, making primary identification a complex task. Thus, the imperative lies in developing a method that fulfills objectivity and effectiveness criteria for depression identification. Current research underscores notable disparities in brain activity between individuals with depression and those without. The Electroencephalogram (EEG), as a biologically reflective and easily accessible signal, is widely used to diagnose depression...
2024: Frontiers in Neuroscience
#34
JOURNAL ARTICLE
Xuan Liu, Jay R Turner, Christopher R Oxford, Jacob McNeill, Brenna Walsh, Emmie Le Roy, Crystal L Weagle, Emily Stone, Haihui Zhu, Wenyu Liu, Zilin Wei, Nicole P Hyslop, Jason Giacomo, Ann M Dillner, Abdus Salam, Al-Amin Hossen, Zubayer Islam, Ihab Abboud, Clement Akoshile, Omar Amador-Muñoz, Nguyen Xuan Anh, Araya Asfaw, Rajasekhar Balasubramanian, Rachel Ying-Wen Chang, Craig Coburn, Sagnik Dey, David J Diner, Jinlu Dong, Tareq Farrah, Paterne Gahungu, Rebecca M Garland, Michel Grutter de la Mora, Sina Hasheminassab, Juanette John, Jhoon Kim, Jong Sung Kim, Kristy Langerman, Pei-Chen Lee, Puji Lestari, Yang Liu, Tesfaye Mamo, Mathieu Martins, Olga L Mayol-Bracero, Mogesh Naidoo, Sang Seo Park, Yoav Schechner, Robyn Schofield, Sachchida N Tripathi, Eli Windwer, Ming-Tsang Wu, Qiang Zhang, Michael Brauer, Yinon Rudich, Randall V Martin
Global ground-level measurements of elements in ambient particulate matter (PM) can provide valuable information to understand the distribution of dust and trace elements, assess health impacts, and investigate emission sources. We use X-ray fluorescence spectroscopy to characterize the elemental composition of PM samples collected from 27 globally distributed sites in the Surface PARTiculate mAtter Network (SPARTAN) over 2019-2023. Consistent protocols are applied to collect all samples and analyze them at one central laboratory, which facilitates comparison across different sites...
April 12, 2024: ACS EST Air
#35
JOURNAL ARTICLE
Bihui Su, Guanghong Du, Shuiping Hou, Zongqiu Chen, Xiaoying Wu, Gang He, Jun Yuan, Chaojun Xie
WHAT IS ALREADY KNOWN ABOUT THIS TOPIC?: S. 1,4,[5],12:i:- and S. Rissen are emerging serotypes of Salmonella that require close monitoring for antimicrobial resistance and containment of their spread. WHAT IS ADDED BY THIS REPORT?: The study aimed to identify antimicrobial resistance genes (ARGs) in S. 1,4,[5],12:i:- and S. Rissen strains isolated from environmental sewage in Guangzhou City, Guangdong Province, China. A phylogenetic tree was constructed using single nucleotide polymorphism data to assess genetic relatedness among strains, offering insights for Salmonella infection outbreak investigations in the future...
March 29, 2024: China CDC weekly
#36
JOURNAL ARTICLE
Juan Alvarado, Keval Yerigeri, Anita Boakye, Christina Randolph, Aparna Roy, Grace Onimoe
COVID-19 infection has been a significant contributor to global morbidity and mortality, especially among those patients with chronic diseases. The Centers for Disease Control and Prevention have classified sickle cell disease (SCD) as a condition that increases the risk of severe illness from COVID-19 infection. A retrospective study was conducted using the TRiNetX health research network database to identify SCA patients ( HbSS, Sbeta-thalassemia zero) who had SARS-CoV-2 infection over 2 years; these were compared with similar patients who did not have the infection in terms of demographics, pain control, and laboratory parameters COVID-19 illness impacts [ain crises and ACS, and prior vaccination against influenza and COVID-19 may represent a protective factor for developing pain crises...
April 2024: EJHaem
#37
JOURNAL ARTICLE
Kirsten J Parker, Louise D Hickman, Julee McDonagh, Richard I Lindley, Caleb Ferguson
INTRODUCTION: Rapid translation of research findings into clinical practice through innovation is critical to improve health systems and patient outcomes. Access to efficient systems of learning underpinned with real-time data are the future of healthcare. This type of health system will decrease unwarranted clinical variation, accelerate rapid evidence translation, and improve overall healthcare quality. METHODS: This paper aims to describe The HARMONY model (acHieving dAta-dRiven quality iMprovement to enhance frailty Outcomes using a learNing health sYstem), a new frailty learning health system model of implementation science and practice improvement...
April 2024: Learning Health Systems
#38
JOURNAL ARTICLE
Nelson M Rumbeli, Furaha August, Valeria Silvestri, Nathanael Sirili
BACKGROUND: With 295 000 maternal deaths in 2017, 94% in low- and middle-income countries, maternal death is a matter of global public health concern. To address it, Maternal Death Surveillance and Response (MDSR) strategy was introduced in 2013 by the World Health Organization. With a reported maternal mortality ratio of 556:100000 per live births, Tanzania adopted the strategy in 2015. Studies are needed to understand factors influencing the implementation of MDSR in this specific setting...
April 2024: Learning Health Systems
#39
JOURNAL ARTICLE
M Laurette Hughes, Laura White, Mary Jane O'Brien, Judy Aubin, Carol Bradford
School closures in March 2020 due to the COVID-19 pandemic precipitated losses of critical student resources as physical, mental, emotional, and social needs escalated. Identifying the challenges, strategies, and changes in school nurse (SN) practice in Massachusetts during this pandemic is fundamental to understanding how to manage future anticipated pandemics while protecting children, communities, and SNs. The purpose of this mixed-methods descriptive study in the second year of the global pandemic was to (a) listen to SN voices through a novel online survey including the prompts of challenges, strategies, and practice changes and (b) describe the SN experience of COVID-19 response in Massachusetts schools, including identification of intent to leave school nursing...
April 18, 2024: Journal of School Nursing: the Official Publication of the National Association of School Nurses
#40
JOURNAL ARTICLE
Amanda Bångstad, Judit Fellman, Carl Rosendahl, Martin Bellander, Matti Cervin, Johan Bjureberg, Lars Klintwall
Adolescent mental health is difficult to capture in categories such as depression or specific anxiety disorders. An alternative is to approach psychiatric symptoms as causal networks, potentially revealing feedback loops that maintain a pathological state. One approach to creating such networks, implemented in the PECAN methodology, is to ask adolescents about their perceptions of the causes to their symptoms. For this purpose, a transdiagnostic item list was created, and adolescents who screened positive for depression ( N = 55) completed twice in two weeks a survey quantifying perceptions of causality between their mental health problems...
April 18, 2024: Journal of Child and Adolescent Mental Health
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