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https://www.readbyqxmd.com/read/29909401/prevalence-and-long-term-survival-after-coronary-artery-bypass-grafting-in-women-and-men-with-heart-failure-and-preserved-versus-reduced-ejection-fraction
#1
Louise Y Sun, Jack V Tu, Anan Bader Eddeen, Peter P Liu
BACKGROUND: Heart failure (HF) with reduced ejection fraction (rEF) is a widely regarded prognosticator after coronary artery bypass grafting. HF with preserved ejection fraction (pEF) accounts for up to half of all HF cases and is associated with considerable morbidity and mortality in hospitalized cohorts. However, HFpEF outcomes have not been elucidated in cardiac surgical patients. We investigated the prevalence and outcomes of HFpEF and HFrEF in women and men following coronary artery bypass grafting...
June 16, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29908961/acute-gastroenteritis-in-a-pediatric-population-from-cali-colombia-in-the-post-rotavirus-vaccine-era
#2
Eduardo López-Medina, Beatriz Parra, Diana M Dávalos, Pio López, Eder Villamarín, Melissa Pelaez
BACKGROUND: In Latin America, there is little epidemiological data resulting from highly sensitive molecular techniques for the study of acute gastroenteritis (AGE) in the post-rotavirus vaccine era. METHODS: Prospective surveillance was performed between March 15, 2015 to March 19, 2016 in two Municipal Health Networks (MHN) from Cali, Colombia to detect AGE in children <5years. Consecutive sampling was performed simultaneously in all health facilities belonging to both MHN until completion of the required sample size...
June 14, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29908917/potential-effectiveness-of-long-acting-injectable-pre-exposure-prophylaxis-for-hiv-prevention-in-men-who-have-sex-with-men-a-modelling-study
#3
Brandon D L Marshall, William C Goedel, Maximilian R F King, Alyson Singleton, David P Durham, Philip A Chan, Jeffrey P Townsend, Alison P Galvani
BACKGROUND: Oral pre-exposure prophylaxis (PrEP) prevents HIV infection in men who have sex with men (MSM); however, adherence is an ongoing concern. Long-acting injectable PrEP is being tested in phase 3 trials and could address challenges associated with adherence. We examined the potential effectiveness of long-acting injectable PrEP compared with oral PrEP in MSM. METHODS: We used an agent-based model to simulate HIV transmission in a dynamic network of 11 245 MSM in Atlanta, GA, USA...
June 13, 2018: Lancet HIV
https://www.readbyqxmd.com/read/29908902/a-study-of-generalizability-of-recurrent-neural-network-based-predictive-models-for-heart-failure-onset-risk-using-a-large-and-heterogeneous-ehr-data-set
#4
Laila R Bekhet, Yonghui Wu, Ningtao Wang, Xin Geng, Wenjin Jim Zheng, Fei Wang, Hulin Wu, Hua Xu, Degui Zhi
Recently, recurrent neural networks (RNNs) have been applied in predicting disease onset risks with Electronic Health Record (EHR) data. While these models demonstrated promising results on relatively small data sets, the generalizability and transferability of those models and its applicability to different patient populations across hospitals have not been evaluated. In this study, we evaluated an RNN model, RETAIN, over Cerner Health Facts® EMR data, for heart failure onset risk prediction. Our data set included over 150,000 heart failure patients and over 1,000,000 controls from nearly 400 hospitals...
June 14, 2018: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/29908775/insulin-resistance-is-associated-with-depression-risk-in-polycystic-ovary-syndrome
#5
Eleni A Greenwood, Lauri A Pasch, Marcelle I Cedars, Richard S Legro, Esther Eisenberg, Heather G Huddleston
OBJECTIVE: To test the hypothesis that insulin resistance is associated with depression risk in polycystic ovary syndrome (PCOS). DESIGN: Secondary analysis of data from a multicenter randomized trial. SETTING: Multicenter university-based clinical practices. PATIENT(S): Seven hundred thirty-eight women with PCOS by modified Rotterdam criteria seeking pregnancy enrolled in a randomized clinical trial comparing clomiphene citrate versus letrozole...
June 13, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29908361/incidence-of-upper-and-lower-gastrointestinal-bleeding-in-new-users-of-low-dose-aspirin
#6
Lucía Cea Soriano, Angel Lanas, Montse Soriano-Gabarró, Luis A García Rodríguez
BACKGROUND & AIMS: There are few data on the incidence of upper and lower gastrointestinal bleeding (UGIB and LGIB) from observational studies of low-dose aspirin users. We aimed to estimate incidence rates of UGIB and LGIB in a large cohort of new users of low-dose aspirin in the United Kingdom, with sub-analyses of hospitalization status and fatalities. METHODS: We performed a population-based study of 199,079 new users of low-dose aspirin (median age, 64...
June 13, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29908310/individual-differences-in-aesthetic-engagement-are-reflected-in-resting-state-fmri-connectivity-implications-for-stress-resilience
#7
Paula G Williams, Kimberley T Johnson, Brian J Curtis, Jace B King, Jeffrey S Anderson
OBJECTIVE: Individual differences in aesthetic engagement-the propensity to be moved by art, nature, and beauty-are associated with positive health outcomes, as well as stress resilience. The purpose of the current study was to identify potential neural substrate mechanisms underlying individual differences in aesthetic engagement and reported proneness to aesthetic chill. METHODS: Data from the Human Connectome Project (HCP) 1200 Subjects Release were utilized...
June 13, 2018: NeuroImage
https://www.readbyqxmd.com/read/29907951/analysis-of-human-c24-bile-acids-metabolome-in-serum-and-urine-based-on-enzyme-digestion-of-conjugated-bile-acids-and-lc-ms-determination-of-unconjugated-bile-acids
#8
Pingping Zhu, Jian Zhang, Yujie Chen, Shanshan Yin, Mingming Su, Guoxiang Xie, Kim L R Brouwer, Changxiao Liu, Ke Lan, Wei Jia
Host-gut microbiota metabolic interactions are closely associated with health and disease. A manifestation of such co-metabolism is the vast structural diversity of bile acids (BAs) involving both oxidative stereochemistry and conjugation. Herein, we describe the development and validation of a LC-MS-based method for the analysis of human C24 BA metabolome in serum and urine. The method has high throughput covering the discrimination of oxidative stereochemistry of unconjugated species in a 15-min analytical cycle...
June 16, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29907582/social-network-characteristics-are-associated-with-type-2-diabetes-complications-the-maastricht-study
#9
Stephanie Brinkhues, Nicole H T M Dukers-Muijrers, Christian J P A Hoebe, Carla J H van der Kallen, Annemarie Koster, Ronald M A Henry, Coen D A Stehouwer, Paul H M Savelkoul, Nicolaas C Schaper, Miranda T Schram
OBJECTIVE: The relation between clinical complications and social network characteristics in type 2 diabetes mellitus (T2DM) has hardly been studied. Therefore, we examined the associations of social network characteristics with macro- and microvascular complications in T2DM and investigated whether these associations were independent of glycemic control, quality of life, and well-known cardiovascular risk factors. RESEARCH DESIGN AND METHODS: Participants with T2DM originated from the Maastricht Study, a population-based cohort study ( n = 797, mean age 62...
June 15, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29907423/understanding-the-impact-of-sex-and-gender-in-alzheimer-s-disease-a-call-to-action
#10
Rebecca A Nebel, Neelum T Aggarwal, Lisa L Barnes, Aimee Gallagher, Jill M Goldstein, Kejal Kantarci, Monica P Mallampalli, Elizabeth C Mormino, Laura Scott, Wai Haung Yu, Pauline M Maki, Michelle M Mielke
INTRODUCTION: Precision medicine methodologies and approaches have advanced our understanding of the clinical presentation, development, progression, and management of Alzheimer's disease (AD) dementia. However, sex and gender have not yet been adequately integrated into many of these approaches. METHODS: The Society for Women's Health Research Interdisciplinary Network on AD, comprised of an expert panel of scientists and clinicians, reviewed ongoing and published research related to sex and gender differences in AD...
May 31, 2018: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29907264/the-world-health-organization-european-healthy-cities-network-30-years-on
#11
John Ashton, Adam Tiliouine, Monika Kosinska
No abstract text is available yet for this article.
June 12, 2018: Gaceta Sanitaria
https://www.readbyqxmd.com/read/29906795/national-survey-of-neonatal-intensive-care-unit-medication-safety-practices
#12
Rachel G Greenberg, P Brian Smith, Carl Bose, Reese H Clark, C Michael Cotten, Chris DeRienzo
OBJECTIVE:  We conducted a detailed survey to identify medication safety practices among a large network of United States neonatal intensive care units (NICUs). METHODS:  We created a 53-question survey to assess 300 U.S. NICU's demographics, medication safety practices, adverse drug event (ADE) reporting, and ADE response plans. RESULTS:  Among the 164 (55%) NICUs that responded to the survey, more than 85% adhered to practices including use of electronic health records, computerized physician order entry, and clinical decision support; fewer reported adopting barcoding, formal safety surveys, and formal culture training; 137 of 164 (84%) developed at least one NICU-specific order-set with a median of 10 order-sets...
June 15, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29906585/medical-concept-normalization-in-social-media-posts-with-recurrent-neural-networks
#13
Elena Tutubalina, Zulfat Miftahutdinov, Sergey Nikolenko, Valentin Malykh
Text mining of scientific libraries and social media has already proven itself as a reliable tool for drug repurposing and hypothesis generation. The task of mapping a disease mention to a concept in a controlled vocabulary, typically to the standard thesaurus in the Unified Medical Language System (UMLS), is known as medical concept normalization. This task is challenging due to the differences in the use of medical terminology between health care professionals and social media texts coming from the lay public...
June 12, 2018: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/29906495/hiv-infection-across-aging-synergistic-effects-on-intrinsic-functional-connectivity-of-the-brain
#14
Anna R Egbert, Bharat Biswal, Keerthana Karunakaran, Agnieszka Pluta, Tomasz Wolak, Stephen Rao, Robert Bornstein, Bogna Szymańska, Andrzej Horban, Ewa Firląg-Burkacka, Marta Sobańska, Natalia Gawron, Przemysław Bieńkowski, Halina Sienkiewicz-Jarosz, Anna Ścińska-Bieńkowska, Emilia Łojek
The objective of the study was to examine additive and synergistic effects of age and HIV infection on resting state (RS) intra- and inter-network functional connectivity (FC) of the brain. We also aimed to assess relationships with neurocognition and determine clinical-, treatment-, and health-related factors moderating intrinsic brain activity in aging HIV-positive (HIV+) individuals. The current report presents data on 54 HIV+ individuals (age M = 41, SD = 12 years) stabilized on cART and 54 socio-demographically matched healthy (HIV-) comparators (age M = 43, SD = 12 years), with cohort education mean of 16 years (SD = 12)...
June 12, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29906421/effectiveness-of-pulmonary-rehabilitation-in-patients-with-chronic-obstructive-pulmonary-disease-with-different-degrees-of-static-lung-hyperinflation
#15
Michiel J E G W Vanfleteren, Maud Koopman, Martijn A Spruit, Herman-Jan Pennings, Frank Smeenk, Willem Pieters, Jan J A M van den Bergh, Arent-Jan Michels, Emiel F M Wouters, Miriam T J Groenen, Frits M E Franssen, Lowie E G W Vanfleteren
OBJECTIVE: To evaluate the effect of pulmonary rehabilitation (PR) on exercise performance and quality of life in patients with chronic obstructive pulmonary disease (COPD) with different degrees of static lung hyperinflation (LH). DESIGN: Retrospective cohort study. SETTING: Pulmonary Rehabilitation Network. PARTICIPANTS: A cohort of 1981 patients with COPD (55% males; age: 66.8 ± 9.3y; FEV1%: 50.7 ± 19.5; RV%: 163...
June 12, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29906322/dressings-and-topical-agents-for-treating-venous-leg-ulcers
#16
REVIEW
Gill Norman, Maggie J Westby, Amber D Rithalia, Nikki Stubbs, Marta O Soares, Jo C Dumville
BACKGROUND: Venous leg ulcers are open skin wounds on the lower leg which can be slow to heal, and are both painful and costly. The point prevalence of open venous leg ulcers in the UK is about 3 cases per 10,000 people, and many people experience recurrent episodes of prolonged ulceration. First-line treatment for venous leg ulcers is compression therapy, but a wide range of dressings and topical treatments are also used. This diversity of treatments makes evidence-based decision-making challenging, and a clear and current overview of all the evidence is required...
June 15, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29906291/a-real-time-medical-cartography-of-epidemic-disease-nodding-syndrome-using-village-based-lay-mhealth-reporters
#17
Raquel Valdes Angues, Austen Suits, Valerie S Palmer, Caesar Okot, Robert A Okot, Concy Atonywalo, Suzanne K Gazda, David L Kitara, Moka Lantum, Spencer S Peter
BACKGROUND: Disease surveillance in rural regions of many countries is poor, such that prolonged delays (months) may intervene between appearance of disease and its recognition by public health authorities. For infectious disorders, delayed recognition and intervention enables uncontrolled disease spread. We tested the feasibility in northern Uganda of developing real-time, village-based health surveillance of an epidemic of Nodding syndrome (NS) using software-programmed smartphones operated by minimally trained lay mHealth reporters...
June 15, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29905915/network-research-experiences-in-new-york-and-eastern-europe-lessons-for-the-southern-us-in-understanding-hiv-transmission-dynamics
#18
REVIEW
Samuel R Friedman, Leslie Williams, April M Young, Jennifer Teubl, Dimitrios Paraskevis, Evangelia Kostaki, Carl Latkin, Danielle German, Pedro Mateu-Gelabert, Honoria Guarino, Tetyana I Vasylyeva, Britt Skaathun, John Schneider, Ania Korobchuk, Pavlo Smyrnov, Georgios Nikolopoulos
PURPOSE: This paper presents an overview of different kinds of risk and social network methods and the kinds of research questions each can address. RECENT FINDINGS: It also reviews what network research has discovered about how network characteristics are associated with HIV and other infections, risk behaviors, preventive behaviors, and care, and discusses some ways in which network-based public health interventions have been conducted. Based on this, risk and social network research and interventions seem both feasible and valuable for addressing the many public health and social problems raised by the widespread use of opioids in the US South...
June 2018: Current HIV/AIDS Reports
https://www.readbyqxmd.com/read/29905861/evaluation-of-a-mobile-approach-to-gender-based-violence-service-delivery-among-syrian-refugees-in-lebanon
#19
Pamela Lilleston, Liliane Winograd, Spogmay Ahmed, Dounia Salamé, Dayana Al Alam, Kirsten Stoebenau, Ilaria Michelis, Sunita Palekar Joergensen
As the landscape of humanitarian response shifts from camp-based to urban- and informal-tented settlement-based responses, service providers and policymakers must consider creative modes for delivering health services. Psychosocial support and case management can be life-saving services for refugee women and girls who are at increased risk for physical, sexual and psychological gender-based violence (GBV). However, these services are often unavailable in non-camp refugee settings. We evaluated an innovative mobile service delivery model for GBV response and mitigation implemented by the International Rescue Committee (IRC) in Lebanon...
June 13, 2018: Health Policy and Planning
https://www.readbyqxmd.com/read/29905855/public-private-partnerships-in-practice-collaborating-to-improve-health-finance-policy-in-ghana-and-kenya
#20
Lauren Suchman, Elizabeth Hart, Dominic Montagu
Social health insurance (SHI), one mechanism for achieving universal health coverage, has become increasingly important in low- and middle-income countries (LMICs) as they work to achieve this goal. Although small private providers supply a significant proportion of healthcare in LMICs, integrating these providers into SHI systems is often challenging. Public-private partnerships in health are one way to address these challenges, but we know little about how these collaborations work, how effectively, and why...
June 13, 2018: Health Policy and Planning
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