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Recurrent rectal cancer

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https://www.readbyqxmd.com/read/29473452/a-new-surgical-device-for-anterograde-intraoperative-rectal-washout
#1
Fabio Rondelli, Roberto Santinelli, Paolo Stella, Walter Bugiantella, Graziano Ceccarelli, Ruben Carlo Balzarotti, Michele De Rosa, Nicola Avenia
BACKGROUND: Colorectal cancer is the fourth most diffuse cause of death in the world and local recurrence is associated with a reduced long-term life expectancy, with a reduced quality of life. Rectal washout at the anastomosis site leads to a statistically significant reduction of local recurrences. METHODS: We developed the idea of a new laparoscopic stapler with an integrated washout system that could decontaminate the rectal stump before resection, without the need to enlarge the standard surgical incision or even to distort the incision site, closing the rectal stump just below the inferior part of the cancer, and then proceeding with the resection and stapling of the distal part of the tumor...
February 1, 2018: Surgical Innovation
https://www.readbyqxmd.com/read/29468354/outcomes-and-prognostic-factors-of-multimodality-treatment-for-locally-recurrent-rectal-cancer-with-curative-intent
#2
Thomas G Bird, Samuel Y Ngan, Julie Chu, René Kroon, Andrew C Lynch, Alexander G Heriot
PURPOSE: Radical management of locally recurrent rectal cancer (LRRC) can lead to prolonged survival. This study aims to assess outcomes and identify prognostic factors for patients with LRRC treated using a multimodality treatment protocol. METHODS: An analysis of a prospectively maintained institutional database of consecutive patients who underwent radical surgical resection for LRRC was performed. Potential prognostic factors were investigated using a Cox proportional hazards model...
February 21, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29468352/local-excision-for-ypt2-rectal-cancer-following-preoperative-chemoradiation-therapy-it-should-not-be-justified
#3
Kwan Mo Yang, Seok-Byung Lim, Jong Lyul Lee, Chan Wook Kim, Yong Sik Yoon, In Ja Park, Chang Sik Yu, Jin Cheon Kim
PURPOSE: Among individuals who respond well to preoperative chemoradiation therapy (CRT) for ypT0-1, local excision (LE) could provide acceptable oncological outcomes. However, in ypT2 cases, the oncological safety of LE has not been determined. This study aimed to compare oncological outcomes between LE and total mesorectal excision of ypT2-stage rectal cancer after chemoradiation therapy and investigate the oncological safety of LE in these patients. METHODS: We included 351 patients who exhibited ypT2-stage rectal cancer after CRT followed by LE (n = 16 [5%]) or total mesorectal excision (TME) (n = 335 [95%]) after preoperative CRT between January 2007 and December 2013...
February 21, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29465604/double-laparoscopy-assisted-cylindrical-abdominal-perineal-resection-for-low-rectal-cancer-with-4-cases-report
#4
Kexin Shen, Xiaofeng Cui, Zhongshi Xie
INTRODUCTION: Rectal cancer is a common cancer worldwide. Low rectal cancer exhibits a tendency for recurrence. Surgical resection is an important treatment for rectal cancer. Cylindrical abdominal-perineal resection is suitable for patients with low rectal cancer and has helped improve the prognosis of these patients. However, there are some difficulties during the operation. Especially the perineal area operation cannot be performed under direct vision, which affects the quality of surgical resection...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29455167/pulmonary-metastasis-in-rectal-cancer-a-retrospective-study-of-clinicopathological-characteristics-of-404-patients-in-chinese-cohort
#5
Hong-Da Pan, Gang Zhao, Qi An, Gang Xiao
OBJECTIVES: This study aim to investigate the incidence, timing and risk factors of metachronous pulmonary recurrence after curative resection in patients with rectal cancer. DESIGN: A retrospective cohort study. SETTING: This study was conducted at a tertiary referral cancer hospital. PARTICIPANTS: A total of 404 patients with rectal cancer who underwent curative resection from 2007 to 2012 at Beijing Hospital were enrolled in this study...
February 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/29454571/feasibility-of-restorative-proctocolectomy-in-patients-with-ulcerative-colitis-associated-lower-rectal-cancer-a-retrospective-study
#6
Shinnosuke Hotta, Yoshifumi Shimada, Mae Nakano, Saki Yamada, Kaoru Abe, Hidehito Oyanagi, Ryoma Yagi, Yosuke Tajima, Masato Nakano, Hitoshi Kameyama, Masayuki Nagahashi, Jun Sakata, Takashi Kobayashi, Toshifumi Wakai
BACKGROUND/OBJECTIVE: Restorative proctocolectomy (RP) may improve quality of life in patients with ulcerative colitis (UC)-associated lower rectal cancer to a greater extent than total proctocolectomy. However, patients with UC-associated cancer often have flat mucosal lesions that make it extremely difficult to endoscopically delineate the tumor margins. Therefore, there is a potential risk of residual tumor and local recurrence after RP in patients with UC-associated lower rectal cancer...
February 14, 2018: Asian Journal of Surgery
https://www.readbyqxmd.com/read/29445870/extralevator-versus-standard-abdominoperineal-excision-in-locally-advanced-rectal-cancer-a-retrospective-study-with-long-term-follow-up
#7
Anu Carpelan, J Karvonen, P Varpe, A Rantala, A Kaljonen, J Grönroos, H Huhtinen
PURPOSE: To analyze the results of abdominoperineal excisions (APE) for locally advanced rectal cancer at our institution before and after the adoption of extralevator abdominoperineal excision (ELAPE) with a special reference to long-term survival. METHODS: A retrospective cohort study conducted in a tertiary referral center. All consecutive patients operated for locally advanced (TNM classification T3-4) rectal cancer with APE in 2004-2009 were compared to patients with similar tumors operated with ELAPE in 2009-2016...
February 14, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29445027/a-curative-intent-trimodality-approach-for-isolated-abdominal-nodal-metastases-in-metastatic-colorectal-cancer-update-of-a-single-institutional-experience
#8
Benny Johnson, Zhaohui Jin, Michael G Haddock, Christopher L Hallemeier, James A Martenson, Rory L Smoot, David W Larson, Eric J Dozois, David M Nagorney, Axel Grothey
BACKGROUND: The purpose of this study was to define survival rates in patients with isolated advanced abdominal nodal metastases secondary to colorectal cancer (CRC), treated with curative-intent trimodality therapy. MATERIALS AND METHODS: Sixty-five patients received trimodality therapy, defined as chemotherapy delivered with external beam radiotherapy (EBRT) followed by lymphadenectomy and intraoperative radiotherapy (IORT). Infusional 5-fluorouracil was the most common radiosensitizer used (63%, 41 patients)...
February 14, 2018: Oncologist
https://www.readbyqxmd.com/read/29442155/outcomes-and-prognostic-factors-of-selective-lateral-pelvic-lymph-node-dissection-with-preoperative-chemoradiotherapy-for-locally-advanced-rectal-cancer
#9
Takeru Matsuda, Yasuo Sumi, Kimihiro Yamashita, Hiroshi Hasegawa, Masashi Yamamoto, Yoshiko Matsuda, Shingo Kanaji, Taro Oshikiri, Tetsu Nakamura, Satoshi Suzuki, Yoshihiro Kakeji
PURPOSE: The clinical significance of preoperative chemoradiotherapy (CRT) and lateral lymph node dissection (LLND) for locally advanced rectal cancer remains unclear. We have employed total mesorectal excision and selective LLND following preoperative CRT for patients with locally advanced rectal cancer. The validity of our strategy was evaluated. METHODS: A total of 45 patients with locally advanced rectal cancer who underwent curative surgery after CRT from November 2005 to September 2016 were retrospectively analyzed...
February 13, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29439668/hipect4-multicentre-randomized-clinical-trial-to-evaluate-safety-and-efficacy-of-hyperthermic-intra-peritoneal-chemotherapy-hipec-with-mitomycin-c-used-during-surgery-for-treatment-of-locally-advanced-colorectal-carcinoma
#10
A Arjona-Sánchez, P Barrios, E Boldo-Roda, B Camps, J Carrasco-Campos, V Concepción Martín, A García-Fadrique, A Gutiérrez-Calvo, R Morales, G Ortega-Pérez, E Pérez-Viejo, A Prada-Villaverde, J Torres-Melero, E Vicente, P Villarejo-Campos, J M Sánchez-Hidalgo, A Casado-Adam, Ruben García-Martin, Manuel Medina, T Caro, C Villar, Enrique Aranda, M T Cano-Osuna, C Díaz-López, E Torres-Tordera, F J Briceño-Delgado, S Rufián-Peña
BACKGROUND: Local relapse and peritoneal carcinomatosis (PC) for pT4 colon cancer is estimated in 15,6% and 36,7% for 12 months and 36 months from surgical resection respectively, achieving a 5 years overall survival of 6%. There are promising results using prophylactic HIPEC in this group of patients, and it is estimated that up to 26% of all T4 colon cancer could benefit from this treatment with a minimal morbidity. Adjuvant HIPEC is effective to avoid the possibility of peritoneal seeding after surgical resection...
February 13, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29439652/advantages-of-a-multi-state-approach-in-surgical-research-how-intermediate-events-and-risk-factor-profile-affect-the-prognosis-of-a-patient-with-locally-advanced-rectal-cancer
#11
G Manzini, T J Ettrich, M Kremer, M Kornmann, D Henne-Bruns, D A Eikema, P Schlattmann, L C de Wreede
BACKGROUND: Standard survival analysis fails to give insight into what happens to a patient after a first outcome event (like first relapse of a disease). Multi-state models are a useful tool for analyzing survival data when different treatments and results (intermediate events) can occur. Aim of this study was to implement a multi-state model on data of patients with rectal cancer to illustrate the advantages of multi-state analysis in comparison to standard survival analysis. METHODS: We re-analyzed data from the RCT FOGT-2 study by using a multi-state model...
February 13, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29430468/endoscopic-submucosal-dissection-of-rectal-cancer-close-to-the-dentate-line-accompanied-by-mucosal-prolapse-syndrome
#12
Hirokazu Honda, Kenji Nakamura, Naoki Ishii, Koyu Suzuki, Katsuyuki Fukuda
A 37-year-old man presented to our hospital for early rectal cancer accompanied by mucosal prolapse syndrome. Biopsy confirmed an adenocarcinoma, and endoscopic ultrasonography indicated proximity to the dentate line but no submucosal invasion. The tumor was removed en bloc via endoscopic submucosal dissection without complications, and its margin was free of tumor cells. The total procedure duration was 37 minutes, and the resected specimen measured 23 × 13 mm. There was no recurrence during the 3-year observation period...
2018: ACG Case Reports Journal
https://www.readbyqxmd.com/read/29427228/the-influence-of-screening-on-outcomes-of-clinically-locally-advanced-rectal-cancer
#13
A M Dinaux, L G J Leijssen, L G Bordeianou, H Kunitake, D L Berger
BACKGROUND: Screening for colorectal cancer has resulted in declining incidence rates of both colon and rectal cancer and it may influence stage at presentation and improve survival. The aim of this study was to assess the impact of screening on patients diagnosed with locally advanced rectal cancer. METHODS: A retrospective analysis of a consecutive series of patients who underwent neoadjuvant therapy and had an R0-resection for clinical AJCC stage II or stage III disease...
February 9, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29420226/serial-circulating-tumour-dna-analysis-during-multimodality-treatment-of-locally-advanced-rectal-cancer-a-prospective-biomarker-study
#14
Jeanne Tie, Joshua D Cohen, Yuxuan Wang, Lu Li, Michael Christie, Koen Simons, Hany Elsaleh, Suzanne Kosmider, Rachel Wong, Desmond Yip, Margaret Lee, Ben Tran, David Rangiah, Matthew Burge, David Goldstein, Madhu Singh, Iain Skinner, Ian Faragher, Matthew Croxford, Carolyn Bampton, Andrew Haydon, Ian T Jones, Christos S Karapetis, Timothy Price, Mary J Schaefer, Jeanne Ptak, Lisa Dobbyn, Natallie Silliman, Isaac Kinde, Cristian Tomasetti, Nickolas Papadopoulos, Kenneth Kinzler, Bert Volgestein, Peter Gibbs
OBJECTIVE: For patients with locally advanced rectal cancer (LARC), adjuvant chemotherapy selection following surgery remains a major clinical dilemma. Here, we investigated the ability of circulating tumour DNA (ctDNA) to improve risk stratification in patients with LARC. DESIGN: We enrolled patients with LARC (T3/T4 and/or N+) planned for neoadjuvant chemoradiotherapy. Plasma samples were collected pretreatment, postchemoradiotherapy and 4-10 weeks after surgery...
February 2, 2018: Gut
https://www.readbyqxmd.com/read/29416206/introduction-to-total-mesorectal-excision
#15
Samir Delibegovic
Colorectal cancer is the second leading cause of mortality in the West, and rectal cancer accounts for about 25% of the colon cancers. The concept of total mesothelial excision (TME) was the most important event in surgery for rectal cancer of the last two decades, because even without a curative approach, it reduced local recurrence and extended 5-year survival.
December 2017: Medical Archives
https://www.readbyqxmd.com/read/29414633/the-impact-of-rectal-cancer-tumor-height-on-recurrence-rates-and-metastatic-location-a-competing-risk-analysis-of-a-national-database
#16
Knut M Augestad, Deborah S Keller, Paul M Bakaki, Johnie Rose, Siran M Koroukian, Tom Øresland, Conor P Delaney
BACKGROUND: The impact of rectal cancer tumor height on local recurrence and metastatic spread is unknown. The objective was to evaluate the impact of rectal cancer tumor height from the anal verge on metastatic spread and local recurrence patterns. METHODS: The Norwegian nationwide surgical quality registry was reviewed for curative rectal cancer resections from 1/1/1996-12/15/2006. Cancers were stratified into five height groups: 0-3 cm, >3-5 cm, >5-9 cm, >9-12 cm, 12 cm-HI...
January 30, 2018: Cancer Epidemiology
https://www.readbyqxmd.com/read/29406806/laparoscopic-versus-conventional-open-abdominoperineal-resection-for-rectal-cancer-an-updated-systematic-review-and-meta-analysis
#17
Xubing Zhang, Qingbin Wu, Tao Hu, Chaoyang Gu, Liang Bi, Ziqiang Wang
BACKGROUND: Laparoscopic abdominoperineal resection (LAPR) for rectal cancer (RC) treatment is still controversial, so we conducted this meta-analysis comparing LAPR with conventional open abdominoperineal resection (OAPR) to explore the safety and feasibility of LAPR for RC treatment. METHODS: A systematic literature search with no limits was performed in PubMed, and Ovid. The last search was performed on June 6, 2017. The outcomes of interests included intraoperative outcomes, pathological outcomes, postoperative outcomes, and survival outcomes...
February 6, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29402298/laparoscopic-low-anterior-resection-for-rectal-cancer-with-rectal-prolapse-a-case-report
#18
Ryusei Yamamoto, Yasuji Mokuno, Hideo Matsubara, Hirokazu Kaneko, Shinsuke Iyomasa
BACKGROUND: Rectal cancer with rectal prolapse is rare, described by only a few case reports. Recently, laparoscopic surgery has become standard procedure for either rectal cancer or rectal prolapse. However, the use of laparoscopic low anterior resection for rectal cancer with rectal prolapse has not been reported. CASE PRESENTATION: A 63-year-old Japanese woman suffered from rectal prolapse, with a mass and rectal bleeding for 2 years. An examination revealed complete rectal prolapse and the presence of a soft tumor, 7 cm in diameter; the distance from the anal verge to the tumor was 5 cm...
February 6, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29398323/delaying-surgery-after-neoadjuvant-chemoradiotherapy-in-rectal-cancer-has-no-influence-in-surgical-approach-or-short-term-clinical-outcomes
#19
Nuno Figueiredo, Sofoklis Panteleimonitis, Sotiris Popeskou, Jose F Cunha, Tahseen Qureshi, Geerard L Beets, Richard J Heald, Amjad Parvaiz
AIMS: In rectal cancer, increasing the interval between the end of neoadjuvant chemoradiotherapy (CRT) and surgery could improve the pathological complete response (pCR) rates, allow full-dose neoadjuvant chemotherapy, and select patients with a clinical complete response (cCR) for inclusion in a "watch & wait" program (W&W). However, controversy arises from waiting more than 8-12 weeks after CRT, as it might increase fibrosis around the total mesorectal excision (TME) plane potentially leading to technical difficulties and higher surgical morbidity...
February 1, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29397634/comparing-outcomes-after-treatment-of-rectal-cancer-over-a-long-lasting-follow-up-between-patients-who-were-offered-to-surgery-alone-and-to-surgery-with-neoadjuvant-therapy-a-single-center-survey-up-to-240-months
#20
Francesco Giudici, Corrado R Asteria, Tatiana Bargellini, Giovanni Alemanno, Alessandro Sturiale, Giuseppe Lucchini, Francesco Tonelli
BACKGROUND: To assess outcomes of patients operated on for rectal cancer (RC) by analysing the trends of disease free survival curves (DFSc) after a very long-term follow-up. METHODS: All patients treated with curative intent for RC from 1986 to 2005 were retrospectively analysed. Other than demographics, disease characteristics and treatment-related factors were considered. The DFSc were compared between patients who had neo-adjuvant therapy (NAT) and those who had surgery alone...
February 1, 2018: Minerva Chirurgica
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