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Recurrent rectal cancer

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https://www.readbyqxmd.com/read/29663303/abdominoperineal-resection-for-rectal-cancer-in-the-twenty-first-century-indications-techniques-and-outcomes
#1
Alexander T Hawkins, Katherine Albutt, Paul E Wise, Karim Alavi, Ranjan Sudan, Andreas M Kaiser, Liliana Bordeianou
BACKGROUND: Management of low rectal cancer continues to be a challenge, and decision making regarding the need for an abdominoperineal resection (APR) in patients with low-lying tumors is complicated. Furthermore, choices need to be made regarding need for modification of the surgical approach based on tumor anatomy and patient goals. DISCUSSION: In this article, we address patient selection, preoperative planning, and intraoperative technique required to perform the three types of abdominoperineal resections for rectal cancer: extrasphincteric, extralevator, and intersphincteric...
April 16, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29661279/sources-of-distress-among-patients-undergoing-surgery-for-colorectal-cancer-a-qualitative-study
#2
Jonathan S Abelson, Alanna Chait, Megan J Shen, Mary Charlson, Anna Dickerman, Heather L Yeo
BACKGROUND: Distress is common among cancer and surgical patients and can lead to worse outcomes if untreated. The objective of this study was to explore sources of distress among colorectal cancer patients undergoing surgery. MATERIALS AND METHODS: This was a qualitative study using in-depth, semistructured, one-on-one interviews in an academic setting. Patients were recruited if they had a pathologically confirmed diagnosis of colon or rectal cancer. Purposive sampling was used to recruit patients who were about to undergo (preoperative), or had recently undergone (postoperative), curative resection for colorectal cancer...
June 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29658675/local-excision-for-rectal-cancer-a-minimally-invasive-option
#3
Marco E Allaix, Alberto Arezzo, Milica Nestorović, Bianca Galosi, Mario Morino
Transanal excision (TAE) with conventional retractors and transanal endoscopic microsurgery (TEM) are two well established minimally invasive surgical options for the treatment of selected rectal cancers. TEM is nowadays considered the standard of care for the transanal excision of rectal tumors, since it is associated with significantly better quality of excision and lower rates of recurrence than TAE. When compared with rectal resection and total mesorectal excision, TEM has lower postoperative morbidity and better functional outcomes, with similar long-term survival rates in selected early rectal cancers...
April 13, 2018: Minerva Chirurgica
https://www.readbyqxmd.com/read/29651788/sphincter-preserving-surgery-for-recurrent-pelvic-malignancy-using-a-hybrid-procedure-of-open-laparotomy-and-transanal-endoscopic-approach
#4
Seiji Ishiguro, Shunichiro Komatsu, Kenichi Komaya, Takuya Saito, Takashi Arikawa, Kenichiro Kaneko, Tsuyoshi Sano
BACKGROUND: Surgery for the treatment of recurrent pelvic malignancy is challenging. Sphincter-preserving surgery (SPS) has been applied in limited cases. Transanal endoscopic approach (TEA) has been used for primary rectal cancer, predominantly for hybrid transabdominal-transanal total mesorectal excision. Here, we describe the use of TEA as a hybrid approach in a case of recurrent ovarian cancer. CASE PRESENTATION: A 59-year-old woman had recurrence of serous ovarian adenocarcinoma in the vaginal stump, near the site of anastomosis from a rectal resection 18 months previously...
April 12, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29650925/-a-case-of-colon-cancer-with-brain-liver-and-lung-metastasis-successfully-treated-with-bevacizumab-plus-xelox-therapy
#5
Tomokazu Tokoro, Keishi Nakamura, Atsushi Hirose, Shinichi Nakanuma, Kohichi Okamoto, Jun Kinoshita, Isamu Makino, Hironori Hayashi, Katsunobu Oyama, Tomoharu Miyashita, Hidehiro Tajima, Hiroyuki Takamura, Itasu Ninomiya, Sachio Fushida, Tetsuo Ohta
The patient was a 57-year-old woman. Preclinical examination of malignant lymphoma revealed 0-I sp type of early rectal cancer in the upper rectum, 20 cm from the anal margin. Endoscopic mucosal resection was performed and positive deep margins were pathologically diagnosed. Additional intestinal resection with lymph node dissection was deemed necessary, but ABVD therapy was initiated because the clinical stage of the malignant lymphoma was Stage III b or higher. Two months after detecting elevated CEA, S8 liver metastasis was pointed out, and examination of weakness of the right upper limb revealed nodular, multifocal brain metastasis...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650913/-a-case-of-laparoscopic-hartmann-s-operation-for-perforation-of-rectal-cancer-in-superior-elderly-people
#6
Tomohito Sakai, Koji Soga, Toru Mizutani, Shunji Kato, Shouji Hirashima, Minoru Nishio, Toshimori Koh, Atsushi Oguro, Noboru Nakagawa
We report a case where home discharge was possible after laparoscopic Hartmann's operation for superior elderly perforation of rectal cancer. The patient was 91-year-old, a woman. She was delivered to the emergency room complaining of weakness. We diagnosed rectal perforation and started emergency laparoscopic surgery. Rectal cancer perforation was observed during surgery and laparoscopic Hartmann's operation plus D2 lymph node dissection was performed. The operation time was 3 hours 21 minutes, the blood loss was 10 g...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650859/-a-retrospective-study-of-preoperative-concurrent-chemoradiotherapy-for-locally-advanced-resectable-rectal-cancer
#7
Yasutake Uchima, Naoki Aomatsu, Chihoko Nobori, Takuma Okada, Hironari Miyamoto, Shigeaki Kurihara, Ryo Takahashi, En Wang, Toshiki Hirakawa, Takehiko Iwauchi, Junya Morimoto, Kazunori Nakazawa, Kazuhiro Takeuchi
PURPOSE: To analyze chemoradiotherapy results for locally advanced rectal cancers at a single institution. METHODS: The study cohort comprised 12 patients with clinically diagnosed T3/4, NX, M0 adenocarcinomas of the rectum who received preoperative chemoradiotherapy. RESULT: Pathological complete response(pCR)were observed in 2/12(16.7%)patients and pathological downstaging in 5/12(41.7%)patients, with generally mild adverse events. CONCLUSION: Preoperative che- moradiotherapy for clinical T3/4, NX rectal cancers significantly reduces local recurrences and improves prognoses...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650857/-two-cases-of-locally-recurrent-rectal-cancer-undergoing-preoperative-chemoradiationtherapy
#8
Yuta Nagatsuka, Katsuki Danno, Susumu Miyazaki, Takamichi Komori, Rie Nakatsuka, Hisaaki Komatsu, Masaaki Motoori, Masaki Kashiwazaki, Kazumasa Fujitani, Kazuhiro Iwase, Mitsukazu Goto
Case 1 is a 68-year-old woman with locally recurrent rectal cancer(LRRC)developed 5 years after resection of primary rectal cancer. The tumor seized right lateral side in pelvic. We performed tumor excision after preoperative chemoradiation comprised external beam radiation with oral S-1(tegafur/gimeracil/oteracil). He has been relapse-free for 3 years 3months after surgery. Case 2 is a 74-year-old man with LRRC developed 2 years after resection of primary rectal cancer. The tumor was located dorsal to anastomosis site in pelvic...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650851/-a-case-of-isolated-lateral-pelvic-lymph-node-recurrence-after-tme-for-early-lower-rectal-cancer-treated-with-laparoscopic-lateral-lymph-node-dissection
#9
Ryuichiro Kimura, Masayoshi Yasui, Masayuki Ohue, Yusuke Takahashi, Norikatsu Miyoshi, Yoshitomo Yanagimoto, Keijiro Sugimura, Akira Tomokuni, Hirofumi Akita, Moon Jeong-Ho, Shogo Kobayashi, Hidenori Takahashi, Takeshi Omori, Yoshiyuki Fujiwara, Hiroshi Miyata, Masahiko Yano, Masato Sakon
There are no established treatment protocol for isolated lateral lymph node recurrence in patients with T1 lower rectal cancer, because such case is very rare. In our institution, this is the only recorded case of lateral node recurrence post-resection. It has been documented in several studies that salvage surgery for colorectal cancer improves prognosis. However, there were only 3 reported cases found for lateral lymph node metastasis from colorectal cancer that underwent excision. In this study, we report a rare case of lateral lymph node recurrence after trans-anal resection for T1 lower rectal cancer wherein we performed laparoscopic right lateral pelvic lymph node dissection...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650844/-super-elderly-recurrent-rectal-cancer-effectively-treated-with-chemotherapy-for-three-years-report-of-a-case
#10
Yasuaki Miyazaki, Kazuo Yamabe, Nobuyasu Hayashi, Toshiya Michiura, Tomo Nakagawa, Satoshi Hyuga, Tomotaka Murotani, Makio Nagaoka
The safety and feasibility of the chemotherapy for super-elderly patients over 85 years old have not been clarified yet. We report an extremely aged patient with recurrent rectal cancer that was successfully treated with chemotherapy. A 85-year-old woman underwent Hartmann procedure for rectal cancer. Nine months after surgery, CT scan revealed liver metastases in S5 and S7. We administered capecitabine plus bevacizumab chemotherapy. Liver metastases were disappeared after 6 courses. Although grade 2 hypertension was appeared, no other adverse event occurred...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650827/-a-case-report-of-complete-resection-of-the-recurrence-small-intestinal-carcinoma-with-abdominal-wall-repair-using-femoral-fascia
#11
Tadafumi Fukata, Taishi Hata, Tateki Kubo, Naotsugu Haraguchi, Hidekazu Takahashi, Junichi Nishimura, Chu Matsuda, Tsunekazu Mizushima, Kou Hosokawa, Yuichiro Doki, Masaki Mori
The patients had Hartmann's operation for rectal cancer when she was 61 years old. After that, she underwent the operation for small bowel cancer when she was 68 years old. After 5 months, the only metastatic lesion was detected near the Scolon stoma. For the first therapy, She received chemotherapy(mFOLFOX6 plus bevacizumab)and had a reducing effect. She was introduced to our hospital for the purpose of resection of the recurrent lesion. CT scan detected a nodule near the Scolon stoma with FDG uptake for PET-CT scan...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29644477/the-selective-use-of-radiation-therapy-in-rectal-cancer-patients
#12
REVIEW
Andrew Martella, Christopher Willett, Manisha Palta, Brian Czito
PURPOSE OF REVIEW: Colorectal cancer has a high global incidence, and standard treatment employs a multimodality approach. In addition to cure, minimizing treatment-related toxicity and improving the therapeutic ratio is a common goal. The following article addresses the potential of omitting radiotherapy in select rectal cancer patients. RECENT FINDINGS: Omission of radiotherapy in rectal cancer is analyzed in the context of historical findings, as well as more recent data describing risk stratification of stage II-III disease, surgical optimization, imaging limitations, improvement in systemic chemotherapeutic agents, and contemporary studies evaluating selective omission of radiotherapy...
April 11, 2018: Current Oncology Reports
https://www.readbyqxmd.com/read/29644427/-gender-specific-differences-of-the-early-postoperative-and-oncosurgical-long-term-outcome-in-rectal-cancer-data-obtained-in-a-prospective-multicenter-observational-study
#13
J Katzenstein, R Steinert, H Ptok, R Otto, I Gastinger, H Lippert, F Meyer
BACKGROUND: Gender-specific aspects have been increasingly considered in clinical medicine, also in oncological surgery. AIM: To analyze gender-specific differences of early postoperative and oncological outcomes after rectal cancer resection based on data obtained in a prospective multicenter observational study. PATIENTS AND METHODS: As part of the multicenter prospective observational study "Quality assurance in primary rectal cancer", data on tumor site, exogenic and endogenic risk factors, neoadjuvant treatment, surgical procedures, tumor stage, intraoperative and postoperative complications of patients with the histological diagnosis of rectal cancer were registered...
April 11, 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29642772/the-assessment-of-clinical-usage-and-prognostic-value-of-ykl-40-serum-levels-in-patients-with-rectal-cancer-without-distant-metastasis
#14
Malgorzata Fuksiewicz, Beata Kotowicz, Andrzej Rutkowski, Joanna Achinger-Kawecka, Michal Wagrodzki, Maria M Kowalska
BACKGROUND: Colorectal cancer is one of the most common and significant malignancies in the world. YKL-40 (chitinase-3-like protein 1) is involved in cell proliferation, migration, inflammation, and tissue remodeling; and serum levels of YKL-40 are associated with patient outcome in various cancers. The aim of this study was to assess the potential clinical usage of YKL-40 pretreatment serum levels as a prognostic biomarker in rectal cancer. METHODS: Concentrations of YKL-40 and standard tumor marker-Carcinoembryonic antigen (CEA)-were assessed in serum of 83 patients with rectal cancer without distant metastasis, and association with clinicopathological characteristics and disease-free and overall survival was evaluated...
January 1, 2018: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/29629355/risk-factors-of-stoma-re-creation-after-closure-of-diverting-ileostomy-in-patients-with-rectal-cancer-who-underwent-low-anterior-resection-or-intersphincteric-resection-with-loop-ileostomy
#15
Ook Song, Kyung Hwan Kim, Soo Young Lee, Chang Hyun Kim, Young Jin Kim, Hyeong Rok Kim
Purpose: The aim of this study was to identify the risk factors of stoma re-creation after closure of diverting ileostomy in patients with rectal cancer who underwent low anterior resection (LAR) or intersphincteric resection (ISR) with loop ileostomy. Methods: We retrospectively reviewed 520 consecutive patients with rectal cancer who underwent LAR or ISR with loop ileostomy from January 2005 to December 2014 at Chonnam National University Hwasun Hospital. Risk factors for stoma re-creation after ileostomy closure were evaluated...
April 2018: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/29614063/comparisons-of-efficacy-safety-and-cost-of-chemotherapy-regimens-folfox4-and-folfirinox-in-rectal-cancer-a-randomized-multicenter-study
#16
Fei Qi, Zhaozheng Zheng, Qiang Yan, Jian Liu, Yan Chen, Guiyang Zhang
BACKGROUND The currently available chemotherapeutic regimens do not use a specifically designed drug delivery system. The objective of this study was to compare outcome measures, adverse effects, and cost of FOLFOX4 and FOLFIRINOX treatments in rectal cancer patients. MATERIAL AND METHODS We enrolled patients who, after surgery, did not undergo chemotherapy or radiotherapy (Control group); were administered 200 mg/m² folinic acid, 400 mg/m² fluorouracil, and 85 mg/m² oxaliplatin (FFO group); or were administered 400 mg/m² folinic acid, 400 mg/m² fluorouracil, 180 mg/m² irinotecan, and 85 mg/m2 oxaliplatin (FFIO group)...
April 3, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29611044/long-term-oncologic-outcomes-after-laparoscopic-versus-open-rectal-cancer-resection-a-high-quality-population-based-analysis-in-a-southern-german-district
#17
Teresa Draeger, Vinzenz Völkel, Michael Gerken, Monika Klinkhammer-Schalke, Alois Fürst
BACKGROUND: An increasing number of rectal carcinoma resections in Germany and worldwide are performed laparoscopically. The recently published COLOR II trial demonstrated the oncologic safety of this surgical approach. It remains unclear whether these findings can be transferred to clinical practice. PATIENTS AND METHODS: This population-based retrospective cohort study aimed to evaluate 5-year overall, relative, disease-free, and local recurrence-free survival of rectal cancer patients treated by open surgery and laparoscopy...
April 2, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29609024/short-interval-between-preoperative-short-course-radiotherapy-and-operation-for-rectal-cancer-increases-anastomotic-leakage
#18
Cloë L Sparreboom, Zhouqiao Wu, Hester F Lingsma, Anand G Menon, Gert-Jan Kleinrensink, Joost J Nuyttens, Michel Wjm Wouters, Johan F Lange
BACKGROUND: Short-course preoperative radiotherapy is indicated in patients with resectable rectal cancer to control local recurrence. Although no clear evidence is available, short-course radiotherapy with surgery within a week is common practice. The aim of this study was to investigate the impact of timing of surgery for rectal cancer after short-course radiotherapy on anastomotic leakage. STUDY DESIGN: Data from the Dutch ColoRectal Audit (DCRA) were used. All patients who received short-course preoperative radiotherapy and underwent elective surgery within 14 days for rectal cancer between January 1st, 2011 and December 31th, 2016 were included...
March 30, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29607633/analysis-of-motion-dependent-clinical-outcome-of-tumor-tracking-stereotactic-body-radiotherapy-for-prostate-cancer
#19
Hoon Sik Choi, Ki Mun Kang, Bae Kwon Jeong, Jin Ho Song, Yun Hee Lee, In Bong Ha, Sung Chul Kam, Jeong Seok Hwa, Jae Seog Hyun, Jungmo Do, Dong Hyeok Jeong, Hojin Jeong
BACKGROUND: To analyze clinical outcome of CyberKnife (CK) tumor-tracking stereotactic body radiotherapy (SBRT) for prostate cancer (Pca) according to the magnitude of intra-fractional prostate motion. METHODS: Medical records and daily treatment logs for 71 patients who received CK tumor-tracking SBRT were retrospectively analyzed. Statistical relationships between prostate motion and various outcome results, including local recurrence (LR), biochemical failure (BF), and treatment-related toxicity, were investigated in order to evaluate motion-dependent efficacy of tumor-tracking SBRT for Pca...
April 2, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29605599/does-repeated-surgery-for-recurrent-colo-rectal-lung-metastases-results-in-improved-survival
#20
Cecilia Menna, Giammauro Berardi, Simone Maria Tierno, Claudio Andreetti, Giulio Maurizi, Anna Maria Ciccone, Antonio D'Andrilli, Francesco Cassiano, Camilla Poggi, Daniele Diso, Federico Venuta, Erino Angelo Rendina, Mohsen Ibrahim
BACKGROUND: Lung metastases occur in 10-20% of patients with colorectal cancer (CRC). Lung metastatic pathways of CRC is poorly known and the optimal management for recurrent lung metastases remains uncertain. METHODS: Long-term oncological outcomes of 203 patients with CRC lung metastases who underwent metastasectomy were investigated in this multicentre retrospective study. Ninety-two (45.3%) patients with tumour relapse underwent repeated metastasectomy and 11 (5...
March 29, 2018: Annals of Thoracic Surgery
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