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https://www.readbyqxmd.com/read/28527887/mst1-deficiency-promotes-b-cell-responses-by-cd4-t-cell-derived-il-4-resulting-in-hypergammaglobulinemia
#1
Eunchong Park, Myun Soo Kim, Ju Han Song, Kyung Min Cho, Kyung-Hye Roh, Rana Lee, Tae Sung Kim
MST1 deficiency causes T and B cell lymphopenia, resulting in combined immunodeficiency. However, MST1-deficient patients also exhibit autoimmune-like symptoms such as hypergammaglobulinemia and autoantibody production. Recent studies have shown that the autoimmune responses observed in MST1-deficient patients were most likely attributable to defective regulatory T (Treg) cells instead of intrinsic signals in MST1-lacking B cells. Nevertheless, it is not determined how MST1 deficiency in T cells breaks B cell tolerance and causes systemic autoimmune-like phenotypes...
May 17, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28526855/gut-homeostasis-and-regulatory-t-cell-induction-depend-on-molecular-chaperone-gp96-in-cd11c-cells
#2
Yunpeng Hua, Yi Yang, Shaoli Sun, Stephen Iwanowycz, Caroline Westwater, Boris Reizis, Zihai Li, Bei Liu
The intestinal immunity and tolerance are orchestrated by both the innate and the adaptive immune system. Intestinal professional antigen presenting cells (pAPCs) recognize and respond to the gut microbiota through multiple pattern-recognition receptors, including TLRs and NLRs. How gut pAPCs maintain mucosal homeostasis remains incompletely understood. Heat shock protein gp96, also known as grp94, is an essential immune chaperone for TLRs. However, the role of gp96 in regulating CD11c(+) APCs in the gut immunity and tolerance is unknown...
May 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28526805/evaluation-of-crescent-formation-as-a-predictive-marker-in-immunoglobulin-a-nephropathy-a-systematic-review-and-meta-analysis
#3
Xue Shao, Bingjue Li, Luxi Cao, Ludan Liang, Jingjuan Yang, Yucheng Wang, Shi Feng, Cuili Wang, Chunhua Weng, Xiujin Shen, Hong Jiang, Jianghua Chen
The 2009 Oxford Classification of immunoglobulin A (IgA) nephropathy (IgAN) identifies four histological features as predictors of renal prognosis: mesangial hypercellularity (M), endocapillary hypercellularity (E), segmental glomerulosclerosis (S), and tubular atrophy/interstitial fibrosis (T). However, the clinical and prognostic significance of crescent formation still remains controversial. Therefore, we performed a meta-analysis to evaluate the association between crescents and kidney outcome in IgAN. A total of 20 studies published from January 2009 to July 2016 involving 5,285 patients were included after systematic searches of PubMed and EMBASE databases...
April 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28526622/9-cis-retinoic-acid-modulates-the-type-i-allergic-immune-response
#4
Guido Heine, Tim Hollstein, Sandra Treptow, Andreas Radbruch, Margitta Worm
BACKGROUND: Vitamin A is a potent regulator of adaptive immunity. The impact of the endogenous metabolite 9-cis retinoic acid (9cRA) on allergic sensitization is unknown. OBJECTIVE: To investigate whether and to what extent 9cRA modulates the humoral immune response. METHODS: BALB/c mice were sensitized and challenged with ovalbumin (OVA). 9cRA was applied repeatedly together with the antigen. Immunoglobulin production and cellular analysis were performed by ELISA, ELISPOTs and flow-cytometry...
May 16, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28524039/-prevention-of-traditional-chinese-medicine-gubiao-pixie-prescription-for-nosocomial-infection-in-elderly-population
#5
Wanxiang Zhang, Bochao Wang, Zhijun Li
OBJECTIVE: To observe the curative effect of traditional Chinese medicine (TCM) Gubiao Pixie prescription on the prevention of nosocomial infection in elderly patients with susceptible factors. METHODS: A prospective observational study was conducted. The elderly patients aged over 70 years admitted to the Department of Integrated TCM and Western Medicine of Tianjin First Center Hospital from March 2015 to March 2016 were enrolled. The patients were divided into experiment group and control group by random number table...
May 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28522940/potential-urine-proteomics-biomarkers-for-primary-nephrotic-syndrome
#6
Young Wook Choi, Yang Gyun Kim, Min-Young Song, Ju-Young Moon, Kyung-Hwan Jeong, Tae-Won Lee, Chun-Gyoo Ihm, Kang-Sik Park, Sang-Ho Lee
BACKGROUND: Nephrotic syndrome (NS) is a nonspecific kidney disorder, commonly caused by minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), and membranous nephropathy (MN). Here we analyzed urinary protein profiles, aiming to discover disease-specific biomarkers of these three common diseases in NS. METHODS: Sixteen urine samples were collected from patients with biopsy-proven NS and healthy controls. After removal of high-abundance proteins, the urinary protein profile was analyzed by LC-MS/MS to generate a discovery set...
2017: Clinical Proteomics
https://www.readbyqxmd.com/read/28522600/frontline-science-nasal-epithelial-gm-csf-contributes-to-tlr5-mediated-modulation-of-airway-dendritic-cells-and-subsequent-iga-response
#7
Yuan Cao, Ejuan Zhang, Jingyi Yang, Yi Yang, Jie Yu, Yang Xiao, Wei Li, Dihan Zhou, Yaoming Li, Bali Zhao, Hu Yan, Mengji Lu, Maohua Zhong, Huimin Yan
Flagellin, as a TLR5 agonist, is an established mucosal adjuvant for enhancing mucosal IgA responses by i.n. immunization. Nasal epithelial cells (NECs) are the first sentinel cells to be exposed to antigen and adjuvant in i.n. immunization, and it is suggested that they play an important role in the mucosal adjuvant activity of flagellin. However, the molecular mechanism leading to modulation and the response by flagellin-activated NECs remain unknown. We aimed to identify the soluble mediator(s) from flagellin-activated NECs that modulate the functions of airway dendritic cells (DCs) and enhance subsequent IgA response...
May 18, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28521688/vasculitis-following-influenza-vaccination-a-review-of-the-literature
#8
Toru Watanabe
BACKGROUND: Influenza vaccine is safe and effective for the general population as well as for patients with autoimmune diseases. However, although rare, vasculitis has been reported as an adverse event following influenza vaccination. OBJECT: The aims of this literature review were to identify patients who developed vasculitis following influenza vaccination and to clarify the clinical manifestations of vasculitis in these patients. METHODS: Using the PubMed database and search engine, we performed a search of the English-language literature by combining the term influenza vaccination with each term for a specific form of vasculitis from January 1966 through April 2016...
May 17, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28521530/influence-of-probiotic-supplementation-on-immune-response-in-broilers-raised-under-hot-climate
#9
M M Fathi, T A Ebeid, I Al-Homidan, N K Soliman, O K Abou-Emera
1. The objective of the study was to evaluate the potential effects of dietary probiotic supplementation and stocking density and their interaction on growth performance, humoral and cellular immune responses of broiler chickens raised under hot climate conditions. 2. A total of 1800 1-d-old unsexed broiler chicks (Ross 308) were allocated in a completely randomised 3 × 2 factorial design, with three concentrations of dietary probiotic (0, 200 and 400 mg/kg) containing 4×10(9) cfu/g of Bacillus subtilis and two stocking densities (12 or 18 birds/m(2)) in a total of 6 treatment sub-groups...
May 18, 2017: British Poultry Science
https://www.readbyqxmd.com/read/28521293/determination-of-il-1b-rs16944-and-il-6-rs1800796-genetic-polymorphisms-in-iga-nephropathy-in-a-northwest-chinese-han-population
#10
Daofa Zhang, Maowei Xie, Xiaohong Yang, Yin Zhang, Yan Su, Yanni Wang, Haiyang Huang, Hui Han, Wenning Li, Keying Fu, Huiluan Su, Wentan Xu, Yeguang Han, Ru Wang, Pei Zhang, Wei Wu, Yun Huang, Daojun Chen, Tianbo Jin, Jiali Wei
IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide, but etiology and pathogenesis continue to be poorly understood. Polymorphisms in the cytokine genes may play a role in the etiology and pathogenesis of IgAN. The incidence of different between diverse ethnic groups suggested important genetic influences on its pathogenesis.We genotype 10 single nucleotide polymorphisms (SNPs) in IL-1B and IL-6 gene using Sequenom Mass-ARRAY technology from 417 IgAN patients and 463 healthy controls of the Chinese Han population...
May 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28516782/exploring-site-specific-n-glycosylation-of-hek293-and-plant-produced-human-iga-isotypes
#11
Kathrin Göritzer, Daniel Maresch, Friedrich Altmann, Christian Obinger, Richard Strasser
The full potential of recombinant Immunoglobulin A as therapeutic antibody is not fully explored, owing to the fact that structure-function relationships of these extensively glycosylated proteins are not well understood. Here, monomeric IgA1, IgA2m(1) and IgA2m(2) variants of the anti-HER2 antibody (IgG1) trastuzumab were expressed in glyco-engineered Nicotiana benthamiana plants and in human HEK293-6E cells. All three IgA isotypes were purified and subjected to biophysical and biochemical characterization...
May 18, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28514363/-the-immunological-characteristics-and-enzymatic-activity-of-lymphocytes-from-the-peripheral-blood-of-the-children-presenting-with-pharyngeal-tonsillar-hypertrophy
#12
L M Kurtasova, N A Shakina, T V Lubnina, A I Nikolaeva
The objective of the present work was to study the immunological characteristics and activity of NAD(P)-dependent dehydrogenases in peripheral blood lymphocytes in the young children presenting with pharyngeal tonsil hypertrophy (PTH). A total of 57 children at the age from 1 to 3 years with PTH were available for the examination. The control group was comprised of 35 age-matched practically healthy children. The amount of CD3+, CD4+, CD8+, CD16+/56-, and CD19+ cells in the peripheral blood was determined with the use of the cytoflowmetric technique...
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/28513788/comparisons-of-iga-response-in-saliva-and-colostrum-against-oral-streptococci-species
#13
Barbara Bellocchio Bertoldo, Camilla Beatriz da Silva, Denise Bertulucci Rocha Rodrigues, Vinicius Rangel Geraldo-Martins, Virginia Paes Leme Ferriani, Ruchele Dias Nogueira
The present study compared IgA specificity against oral streptococci in colostrum and saliva samples. Sixty-two mother-and-child pairs were included; samples of colostrum (C) and saliva (MS) were collected from the mothers and saliva samples were collected from babies (BS). The specificity of IgA against Streptococcus mutans and S. mitis were analyzed by western blot. Only 30% of babies' samples presented IgA reactivity to S. mutans, while 74 and 80% of MS and C, respectively, presented this response. IgA reactivity to S...
May 15, 2017: Brazilian Oral Research
https://www.readbyqxmd.com/read/28512356/adamdec1-ednrb-and-ptgs1-cox1-inflammation-genes-upregulated-in-the-intestinal-mucosa-of-obese-rats-are-downregulated-by-three-probiotic-strains
#14
Julio Plaza-Díaz, Cándido Robles-Sánchez, Francisco Abadía-Molina, Virginia Morón-Calvente, María José Sáez-Lara, Alfonso Ruiz-Bravo, María Jiménez-Valera, Ángel Gil, Carolina Gómez-Llorente, Luis Fontana
We have previously reported that administration of Lactobacillus paracasei CNCM I-4034, Bifidobacterium breve CNCM I-4035 and Lactobacillus rhamnosus CNCM I-4036 to obese Zucker-Lepr (fa/fa) rats attenuates liver steatosis and exerts anti-inflammatory effects. The goal of the present work was to investigate the modulation of gene expression in intestinal mucosa samples of obese Zucker-Lepr (fa/fa) rats fed the probiotic strains using a DNA microarray and postgenomic techniques. We also measured secretory IgA content in the gut and lipopolysaccharide (LPS)-binding protein (LBP) in serum...
May 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28508962/proteinuria-rebound-in-iga-nephropathy-associated-with-obesity-related-glomerulopathy
#15
Hiro Matsukura, Masako Sakakibara, Izumi Sakamoto, Miho Tatematsu
IgA nephropathy (IgAN), the most prevalent primary chronic glomerulonephritis worldwide, has three major risk factors: hypertension, proteinuria >1 g/day, and severe renal lesions. Obesity also portends a poor prognosis. A Japanese boy with IgAN showed nephrotic syndrome at presentation. Pathological features resembled those of membranoproliferative glomerulonephritis (MPGN), although IgA deposition differed from MPGN and IgAN. Combination therapy improved renal lesions, but rebound deterioration of proteinuria occurred in this patient, who had marked obesity and hypertension...
November 2016: CEN Case Reports
https://www.readbyqxmd.com/read/28506354/-immunoprotective-effect-of-combined-pneumococcal-endopeptidase-o-and-pneumococcal-surface-adhesin-a-vaccines-against-streptococcus-pneumoniae-infection
#16
Jing Zhang, Ya-Li Cui, Yong-Mei Jiang
OBJECTIVE: To investigate the prokaryotic expression of proteins pneumococcal endopeptidase O (PepO) and pneumococcal surface adhesin A (PsaA) in Streptococcus pneumoniae and their immunoprotective effect as vaccine candidate proteins. METHODS: Specific primers of target gene fragments were designed, and then PCR amplification was performed to establish recombinant plasmids pET28a(+)-pepO and pET28a(+)-psaA, which were transformed into host cells, Escherichia coli BL21 and DE3, respectively, to induce expression...
May 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28505540/salivary-protective-factors-in-patients-suffering-from-decompensated-type-2-diabetes
#17
Marcin Chorzewski, Karolina Orywal, Teresa Sierpinska, Maria Golebiewska
PURPOSE: Defining the level of protective factors in saliva of patients suffering from decompensated type 2 diabetes. MATERIAL AND METHODS: 50 Patients with diagnosis of decompensated type 2 diabetes, including 32 women and 18 men at the age of 57.9±9.2 years. The control group consisted of 50 people among whom there were 38 women and 12 men whose average age was estimated at 51.2±9.9 years. RESULTS: It was stated the increased concentration of total protein by 60% and decreased concentration of IgA by 70%, of lysozyme by 27% and of lactoferrin by 40% in resting saliva of patients with type 2 diabetes if compared to the control group...
May 12, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/28504566/influence-of-lactobacillus-reuteri-l26-biocenol%C3%A2-on-immune-response-against-porcine-circovirus-type-2-infection-in-germ-free-mice
#18
V Karaffová, T Csank, D Mudroňová, J Király, V Revajová, S Gancarčíková, R Nemcová, J Pistl, Š Vilček, M Levkut
Probiotic bacteria are frequently used for prevention of bacterial infections of the gastrointestinal tract, but there are only limited studies on their efficacy against viral gut infections in animals. The aim of this study was to investigate the effect of probiotic Lactobacillus reuteri L26 Biocenol(TM) on the innate and adaptive immune responses in germ-free Balb/c mice, experimentally infected by porcine circovirus type 2 (PCV2), which confers immunosuppressive effect. A total of 30 six-week-old female mice were divided into 3 groups and animals in experimental group LPCV (n=10) were inoculated with L...
May 15, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28504097/humoral-immune-responses-of-experimentally-eimeria-ninakholyakimovae-infected-goat-kids
#19
Lorena Matos, María Del Carmen Muñoz, José Manuel Molina, Otilia Ferrer, Francisco Rodríguez, Davinia Pérez, Adassa María López, Sergio Martín, Carlos Hermosilla, Anja Taubert, Antonio Ruiz
Although cellular immune reactions seem to be crucial for protective immune responses in Eimeria spp. infections, there are also evidences on an active involvement of the humoral counterpart. In the present study, we have analyzed the humoral response of goat kids subjected to primary and challenge infections with Eimeria ninakholyakimovae. Specific levels of IgG and IgM in serum samples and IgA in the ileal mucus were estimated. In infected kids, significantly increased levels of IgG were observed from 3 weeks post infection onwards in addition to an enhancement of specific IgM and secretory IgA levels...
April 2017: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/28502679/the-association-between-semaphorin-3a-levels-and-gluten-free-diet-in-patients-with-celiac-disease
#20
Aharon Kessel, Chen Lin, Zahava Vadasz, Regina Peri, Nasren Eiza, Drora Berkowitz
Celiac disease (CD) is an inflammatory disease affecting the small intestine. We aim to assess serum level and expression of semaphorin 3A (Sema3A) on T regulatory (Treg) cells in CD patients. Twenty-six newly diagnosed celiac patients, 13 celiac patients on a gluten-free diet and 16 healthy controls included in the study. Sema3A protein level in the serum of celiac patients was significantly higher compared to healthy group (7.17±1.8ng/ml vs. 5.67±1.5ng/ml, p=0.012). Sema3A expression on Treg cells was statistically lower in celiac patients compared to healthy subjects (p=0...
May 11, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
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