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Long-chain omega-3 PUFA

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https://www.readbyqxmd.com/read/29136189/serum-omega-3-fatty-acids-and-treatment-outcomes-among-women-undergoing-assisted-reproduction
#1
Y-H Chiu, A E Karmon, A J Gaskins, M Arvizu, P L Williams, I Souter, B R Rueda, R Hause, J E Chavarro
STUDY QUESTION: Are serum polyunsaturated fatty acids (PUFA) concentrations, including omega-3 (ω3-PUFA) and omega-6 (ω6-PUFA), related to ART outcomes? SUMMARY ANSWER: Serum levels of long-chain ω3-PUFA were positively associated with probability of live birth among women undergoing ART. WHAT IS KNOWN ALREADY: Intake of ω3-PUFA improves oocyte and embryo quality in animal and human studies. However, a recent cohort study found no relation between circulating ω3-PUFA levels and pregnancy rates after ART...
November 10, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29118465/antioxidant-and-anti-inflammatory-activities-in-extracts-from-minke-whale-balaenoptera-acutorostrata-blubber
#2
Mari Johannessen Walquist, Svein Kristian Stormo, Ida-Johanne Jensen, Bjarne Østerud, Karl-Erik Eilertsen
Intake of long-chain omega-3 polyunsaturated fatty acids (LC-n3-PUFA) is commonly recognized to reduce cardiovascular disease (CVD). In previous studies, cold-pressed whale oil (CWO) and cod liver oil (CLO) were given as a dietary supplement to healthy volunteers. Even though CWO contains less than half the amount of LC-n3-PUFA of CLO, CWO supplement resulted in beneficial effects on anti-inflammatory and CVD risk markers compared to CLO. In the present study, we prepared virtually lipid-free extracts from CWO and CLO and evaluated the antioxidative capacity (AOC) and anti-inflammatory effects...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/29089890/long-chain-omega-3-fatty-acids-supplementation-accelerates-nerve-regeneration-and-prevents-neuropathic-pain-behavior-in-mice
#3
Rafaela V Silva, Julia T Oliveira, Bruna L R Santos, Fabiana C Dias, Ana M B Martinez, Cleverton K F Lima, Ana L P Miranda
Fish oil (FO) is the main source of long chain omega-3 polyunsaturated fatty acids (ω-3 PUFAs), which display relevant analgesic and anti-inflammatory properties. Peripheral nerve injury is driven by degeneration, neuroinflammation, and neuronal plasticity which results in neuropathic pain (NP) symptoms such as allodynia and hyperalgesia. We tested the preventive effect of an EPA/DHA-concentrate fish oil (CFO) on NP development and regenerative features. Swiss mice received daily oral treatment with CFO 4...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29082420/substrate-specificity-and-membrane-topologies-of-the-iron-containing-%C3%AF-3-and-%C3%AF-6-desaturases-from-mortierella-alpina
#4
Mingxuan Wang, Haiqin Chen, Aisikaer Ailati, Wei Chen, Floyd H Chilton, W Todd Lowther, Yong Q Chen
Polyunsaturated fatty acids (PUFAs) are essential lipids for cell function, normal growth, and development, serving as key structural components of biological membranes and modulating critical signal transduction events. Omega-3 (n-3) long chain PUFAs (LC-PUFAs) such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been shown to protect against inflammatory diseases and enhance brain development and function. This had led to a marked increase in demand for fish and fish oils in human diets, supplements, and aquaculture and created a need for new, sustainable n-3 LC-PUFA sources...
October 30, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29080699/therapeutic-potential-of-omega-3-fatty-acid-derived-epoxyeicosanoids-in-cardiovascular-and-inflammatory-diseases
#5
REVIEW
Wolf-Hagen Schunck, Anne Konkel, Robert Fischer, Karsten-Henrich Weylandt
Numerous benefits have been attributed to dietary long-chain omega-3 polyunsaturated fatty acids (n-3 LC-PUFAs), including protection against cardiac arrhythmia, triglyceride-lowering, amelioration of inflammatory, and neurodegenerative disorders. This review covers recent findings indicating that a variety of these beneficial effects are mediated by "omega-3 epoxyeicosanoids", a class of novel n-3 LC-PUFA-derived lipid mediators, which are generated via the cytochrome P450 (CYP) epoxygenase pathway. CYP enzymes, previously identified as arachidonic acid (20:4n-6; AA) epoxygenases, accept eicosapentaenoic acid (20:5n-3; EPA) and docosahexaenoic acid (22:6n-3; DHA), the major fish oil n-3 LC-PUFAs, as efficient alternative substrates...
October 25, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29079039/neurocognitive-effects-of-an-omega-3-fatty-acid-and-vitamins-e-c-in-schizophrenia-a-randomised-controlled-trial
#6
H Bentsen, N I Landrø
There is need for more efficient treatment of neurocognitive deficits in schizophrenia. In this 16 weeks randomised, placebo-controlled trial, we examined neurocognitive effects of adding ethyl-eicosapentaenoate 2g/day and/or vitamins E 364mg/day + C 1000mg/day to antipsychotics in 53 patients aged 18-39 years with acute schizophrenia. For the sake of validating neurocognitive tests, healthy subjects, not taking trial drugs, were also included in the study. Ethyl-EPA given alone to patients with low baseline RBC polyunsaturated fatty acids (PUFA), and Vitamins E+C given alone to high PUFA patients, impaired sustained attention (Continuous Performance Test, CPT-IP d prime score), standardised effect sizes d = 0...
October 16, 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29068398/precision-nutrition-and-omega-3-polyunsaturated-fatty-acids-a-case-for-personalized-supplementation-approaches-for-the-prevention-and-management-of-human-diseases
#7
REVIEW
Floyd H Chilton, Rahul Dutta, Lindsay M Reynolds, Susan Sergeant, Rasika A Mathias, Michael C Seeds
BACKGROUND: Dietary essential omega-6 (n-6) and omega-3 (n-3) 18 carbon (18C-) polyunsaturated fatty acids (PUFA), linoleic acid (LA) and α-linolenic acid (ALA), can be converted (utilizing desaturase and elongase enzymes encoded by FADS and ELOVL genes) to biologically-active long chain (LC; >20)-PUFAs by numerous cells and tissues. These n-6 and n-3 LC-PUFAs and their metabolites (ex, eicosanoids and endocannabinoids) play critical signaling and structural roles in almost all physiologic and pathophysiologic processes...
October 25, 2017: Nutrients
https://www.readbyqxmd.com/read/29031393/cytokine-distribution-in-mothers-and-breastfed-children-after-omega-3-lcpufas-supplementation-during-the-last-trimester-of-pregnancy-and-the-lactation-period-a-randomized-controlled-trial
#8
Y Rodriguez-Santana, J J Ochoa, F Lara-Villoslada, N Kajarabille, P Saavedra-Santana, J A Hurtado, M Peña, J Diaz-Castro, I Sebastian-Garcia, E Machin-Martin, M Villanueva, O Ramirez-Garcia, L Peña-Quintana
OBJECTIVE: To determine whether maternal diet supplementation with omega-3 long chain polyunsaturated fatty acids (omega-3 LC-PUFAs) during the last trimester of pregnancy and the breastfeeding period influences the levels of inflammatory cytokines in mother and infants. MATERIAL AND METHOD: This registered, double-blind randomized study included 46 pregnant women, who were randomly allocated to either an experimental group receiving 400mL/day of a fish oil-enriched dairy drink [320mg docosahexaenoic acid (DHA) + 72mg eicoapentaenoic acid] (FO group, n = 24) or to a control group receiving 400mL/day of a non-supplemented dairy drink (CT group, n = 22), from week 28 of pregnancy until the fourth month of lactation...
November 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28987470/potential-therapeutic-impact-of-omega-3-long-chain-polyunsaturated-fatty-acids-on-inflammation-markers-in-duchenne-muscular-dystrophy-a-double-blind-controlled-randomized-trial
#9
Maricela Rodríguez-Cruz, Oriana Del Rocío Cruz-Guzmán, Tomás Almeida-Becerril, Alan Donovan Solís-Serna, Salvador Atilano-Miguel, Juan Raúl Sánchez-González, Lourdes Barbosa-Cortés, Eugenia Dolores Ruíz-Cruz, Juan Carlos Huicochea, Alan Cárdenas-Conejo, Rosa Elena Escobar-Cedillo, Carlos Alberto Yam-Ontiveros, Edgar F Ricárdez-Marcial
BACKGROUND & AIMS: Duchenne Muscular Dystrophy (DMD) is the most frequent dystrophy in childhood generated by a deficiency in dystrophin. DMD is a neuromuscular disease and its clinical course comprises chronic inflammation and gradual muscle weakness. Supplementation of omega-3 long chain-Polyunsaturated Fatty Acids (ω-3 long chain-PUFA) reduces inflammatory markers in various disorders. The goal of this research was to analyze the influence of ω-3 long chain-PUFA intake on gene expression and blood inflammatory markers in boys with DMD...
September 23, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28958564/characterization-of-lipids-in-three-species-of-sea-urchin
#10
Xin Zhou, Da-Yong Zhou, Ting Lu, Zhong-Yuan Liu, Qi Zhao, Yu-Xin Liu, Xiao-Pei Hu, Jiang-Hua Zhang, Fereidoon Shahidi
Sea urchin gonad has been regarded as a "healthy" food. Although previous studies have suggested that sea urchin gonad might serve as a potential rich source of long chain omega-3 polyunsaturated fatty acids (n-3 LC-PUFA) enriched phospholipid (PL), the molecular species profile of its PL has rarely been reported. In this study, about 200 molecular species of glycerophospholipid (GP), including glycerophosphocholine, glycerophosphoethanolamine, glycerophosphoserine, glycerophosphoinositol, lysoglycerophosphocholine and lysoglycerophosphoethanolamine, in gonads from three species of sea urchin (Glyptocidaris crenularis, Strongylocentrotus intermedius and Strongylocentrotus nudus) were characterized using tandem mass spectrometry...
February 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28944596/diet-quality-in-patients-with-end-stage-kidney-disease-undergoing-dialysis
#11
Lauren A Roach, Kelly Lambert, Jane L Holt, Barbara J Meyer
BACKGROUND: People on haemodialysis (HD) are at risk of consuming a poor quality diet. This includes inadequate intake of omega-3 long chain polyunsaturated fatty acids (n-3 LCPUFA). OBJECTIVE: This study aims to investigate diet quality, with a particular focus on n-3 LCPUFA intake, in a population of incentre HD patients. DESIGN: Dietary intake was measured using three 24 hour recalls; the Polyunsaturated food frequency questionnaire (PUFA FFQ) and the Total Diet Score (TDS)...
December 2017: Journal of Renal Care
https://www.readbyqxmd.com/read/28854755/omega-3-polyunsaturated-fatty-acids-provided-during-embryonic-development-improve-the-growth-performance-and-welfare-of-muscovy-ducks-cairina-moschata
#12
E Baéza, P Chartrin, T Bordeau, M Lessire, J M Thoby, V Gigaud, M Blanchet, A Alinier, C Leterrier
The welfare of ducks can be affected by unwanted behaviors such as excessive reactivity and feather pecking. Providing long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFA) during gestation and early life has been shown to improve the brain development and function of human and rodent offspring. The aim of this study was to test whether the pecking behavior of Muscovy ducks during rearing could be reduced by providing LC n-3 PUFA during embryonic and/or post-hatching development of ducklings. Enrichment of eggs, and consequently embryos, with LC n-3 PUFA was achieved by feeding female ducks (n-3F) a diet containing docosahexaenoic (DHA) and linolenic acids (microalgae and linseed oil)...
September 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/28839364/omega-3-fish-oil-reduces-mortality-due-to-severe-sepsis-with-acute-gastrointestinal-injury-grade-iii
#13
Huaisheng Chen, Wei Wang, Chengying Hong, Ming Zhang, Yingcai Hong, Su Wang, Huadong Zhang
BACKGROUND: Sepsis plays an important role in acute gastrointestinal injury (AGI). Our research was designed to determine the effects of omega-3 fish oil (FO) in patients suffering from severe sepsis combined with AGI III, and the ability of FO to modulate immune function. METHODS: Seventy-eight patients diagnosed with severe sepsis with AGI III and a need for mechanical ventilation were randomized to two groups. In the FO group, 50 g of long chain fatty acid soybean oil (n = 6) and 10 g of FO (n = 3) were administered as total parenteral nutrition (TPN)...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28835852/degummed-crude-canola-oil-sire-breed-and-gender-effects-on-intramuscular-long-chain-omega-3-fatty-acid-properties-of-raw-and-cooked-lamb-meat
#14
Aaron Ross Flakemore, Bunmi Sherifat Malau-Aduli, Peter David Nichols, Aduli Enoch Othniel Malau-Aduli
BACKGROUND: Omega-3 long-chain (≥C20) polyunsaturated fatty acids (ω3 LC-PUFA) confer important attributes to health-conscious meat consumers due to the significant role they play in brain development, prevention of coronary heart disease, obesity and hypertension. In this study, the ω3 LC-PUFA content of raw and cooked Longissimus thoracis et lumborum (LTL) muscle from genetically divergent Australian prime lambs supplemented with dietary degummed crude canola oil (DCCO) was evaluated...
2017: Journal of Animal Science and Technology
https://www.readbyqxmd.com/read/28817082/omega-3-long-chain-fatty-acids-in-the-heart-kidney-liver-and-plasma-metabolite-profiles-of-australian-prime-lambs-supplemented-with-pelleted-canola-and-flaxseed-oils
#15
Don V Nguyen, Van H Le, Quang V Nguyen, Bunmi S Malau-Aduli, Peter D Nichols, Aduli E O Malau-Aduli
The objective of the study was to ascertain whether human health beneficial omega-3 long-chain (≥C20) polyunsaturated fatty acid (n-3 LC-PUFA) content in heart, kidney and liver can be enhanced by supplementing prime lambs with graded levels of canola and flaxseed oil. Health status of the lambs, as a consequence of the supplementation, was also investigated by examining their plasma metabolites. Sixty purebred and first-cross lambs were allocated to one of five treatments of lucerne hay basal diet supplemented with isocaloric and isonitrogenous wheat-based pellets without oil inclusion (Control) or graded levels of canola oil at 2...
August 17, 2017: Nutrients
https://www.readbyqxmd.com/read/28802305/fish-long-chain-omega-3-polyunsaturated-fatty-acids-consumption-and-risk-of-all-cause-mortality-a-systematic-review-and-dose-response-meta-analysis-from-23-independent-prospective-cohort-studies
#16
Yi Wan, Jusheng Zheng, Fenglei Wang, Duo Li
BACKGROUND AND OBJECTIVES: The consumption of fish and long chain omega-3 polyunsaturated fatty acids (n-3 PUFA) may influence the risk of all-cause mortality, but the findings have been inconsistent. The current systematic review and meta-analysis is to clarify the association between fish and long chain n-3 PUFA consumption with risk of all-cause mortality. METHODS AND STUDY DESIGN: Studies published before March 2017 were identified through electronic searches using PubMed, Scopus and Web of Science database...
2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28770178/chemopreventive-and-chemotherapeutic-effects-of-fish-oil-derived-omega-3-polyunsaturated-fatty-acids-on-colon-carcinogenesis
#17
REVIEW
Ja Young Lee, Tae-Bu Sim, Jeong-Eun Lee, Hye-Kyung Na
Colorectal cancer is the third most common cause of cancer related death in the world. Multiple lines of evidence suggest that there is an association between consumption of dietary fat and colon cancer risk. Not only the amount but also the type and the ratio of fatty acids comprising dietary fats consumed have been implicated in the etiology and pathogenesis of colon cancer. Omega-3 (n-3) polyunsaturated fatty acids (PUFAs), such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), have been known to inhibit development of colon cancer by downregulating the expression of genes involved in colon carcinogenesis and also by altering the membrane lipid composition...
July 2017: Clinical Nutrition Research
https://www.readbyqxmd.com/read/28754005/can-early-omega-3-fatty-acid-exposure-reduce-risk-of-childhood-allergic-disease
#18
REVIEW
Elizabeth A Miles, Philip C Calder
A causal link between increased intake of omega-6 (n-6) polyunsaturated fatty acids (PUFAs) and increased incidence of allergic disease has been suggested. This is supported by biologically plausible mechanisms, related to the roles of eicosanoid mediators produced from the n-6 PUFA arachidonic acid. Fish and fish oils are sources of long chain omega-3 (n-3) PUFAs. These fatty acids act to oppose the actions of n-6 PUFAs particularly with regard to eicosanoid synthesis. Thus, n-3 PUFAs may protect against allergic sensitisation and allergic manifestations...
July 21, 2017: Nutrients
https://www.readbyqxmd.com/read/28752333/significance-of-long-chain-polyunsaturated-fatty-acids-in-human-health
#19
REVIEW
Rafael Zárate, Nabil El Jaber-Vazdekis, Noemi Tejera, José A Pérez, Covadonga Rodríguez
In the last decades, the development of new technologies applied to lipidomics has revitalized the analysis of lipid profile alterations and the understanding of the underlying molecular mechanisms of lipid metabolism, together with their involvement in the occurrence of human disease. Of particular interest is the study of omega-3 and omega-6 long chain polyunsaturated fatty acids (LC-PUFAs), notably EPA (eicosapentaenoic acid, 20:5n-3), DHA (docosahexaenoic acid, 22:6n-3), and ARA (arachidonic acid, 20:4n-6), and their transformation into bioactive lipid mediators...
December 2017: Clinical and Translational Medicine
https://www.readbyqxmd.com/read/28721583/microbial-and-genetically-engineered-oils-as-replacements-for-fish-oil-in-aquaculture-feeds
#20
REVIEW
M Sprague, M B Betancor, D R Tocher
As the global population grows more of our fish and seafood are being farmed. Fish are the main dietary source of the omega-3 (n-3) long-chain polyunsaturated fatty acids (LC-PUFA), eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids, but these cannot be produced in sufficient quantities as are now required for human health. Farmed fish have traditionally been fed a diet consisting of fishmeal and fish oil, rich in n-3 LC-PUFA. However, the increase in global aquaculture production has resulted in these finite and limited marine ingredients being replaced with sustainable alternatives of terrestrial origin that are devoid of n-3 LC-PUFA...
November 2017: Biotechnology Letters
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