keyword
https://read.qxmd.com/read/38522783/omega-3-polyunsaturated-fatty-acid-status-testing-in-humans-a-narrative-review-of-commercially-available-options
#1
REVIEW
Mary R Dicklin, Joshua C Anthony, Barbara L Winters, Kevin C Maki
There is an increasing body of evidence supporting a link between low intakes of omega-3 long chain polyunsaturated fatty acids (LCPUFA) and numerous diseases and health conditions. However, few people are achieving the levels of fish/seafood or eicosapentaenoic acid and docosahexaenoic acid intake recommended in national and international guidelines. Knowledge of a person's omega-3 LCPUFA status will benefit the interpretation of research results and could be expected to lead to an increased effort to increase intake...
March 22, 2024: Journal of Nutrition
https://read.qxmd.com/read/38493279/accumulation-of-docosapentaenoic-acid-n-3-dpa-in-a-novel-isolate-of-the-marine-ichthyosporean-sphaeroforma-arctica
#2
JOURNAL ARTICLE
Qiang Wilson Yan, Ying-Chun Liu, Christa Barrett, Kelly Haake, Daniel Seeler, Oliver May, Ross Zirkle
OBJECTIVE: Currently, there is lack of a consistent and highly enriched source for docosapentaenoic acid (n-3 DPA, C22:5), and this work report the isolation of microorganism that naturally produces n-3 DPA. RESULTS: In this work, we screened microorganisms in our culture collections with the goal to isolate a strain with high levels of n-3 DPA. We isolated a strain of Sphaeroforma arctica that produces up to 11% n-3 DPA in total fatty acid and has a high n-3 DPA to DHA/EPA ratio...
March 16, 2024: Biotechnology Letters
https://read.qxmd.com/read/38461255/muscle-biopsy-long-chain-omega-3-polyunsaturated-fatty-acid-compositions-imf-and-fmp-in-australian-pasture-based-bowen-genetics-forest-pastoral-angus-hereford-and-wagyu-beef-cattle
#3
JOURNAL ARTICLE
John Roger Otto, Felista Waithira Mwangi, Shedrach Benjamin Pewan, Oyelola Abdulwasiu Adegboye, Aduli Enoch Othniel Malau-Aduli
BACKGROUND: We investigated breed and gender variations in the compositions of long-chain (≥ C20) omega-3 polyunsaturated fatty acids (LC omega-3 PUFA), fat melting point (FMP) and intramuscular fat (IMF) contents in biopsy samples of the M. longissimus dorsi muscle of grazing beef cattle. The hypothesis that biopsy compositions of health-beneficial LC omega-3 PUFA, FMP and IMF in a pasture-based production system will vary with breed, was tested. Muscle biopsies were taken from 127 yearling pasture-based Angus, Hereford, and Wagyu heifers and young bulls exclusive to the Australian Bowen Genetics Forest Pastoral breeding stud averaging 12 ± 2...
March 9, 2024: BMC Veterinary Research
https://read.qxmd.com/read/38387522/toxicological-evaluation-of-a-fish-oil-concentrate-containing-very-long-chain-fatty-acids
#4
JOURNAL ARTICLE
Derek Tobin, Harald Svensen, Devanand Shanmugasundaram, Bente Ruyter, Iren Stoknes, Michael Dornish
Very long chain fatty acids (VLCFA) have a chain length ≥24 carbons. Fish contain low levels of these fatty acids. A commercial oil called EPAX® Evolve 05 with an up-concentration of VLCFAs of approximately 10 times, has been developed as a dietary supplement by Epax Norway AS. A series of toxicological studies were performed using mice and rats to determine the safety and toxicity of repeat dosing with a gavage administered VLCFA formulation. The results suggest transient lipid accumulation in kidneys and liver...
February 20, 2024: Food and Chemical Toxicology
https://read.qxmd.com/read/38374149/omega-3-fatty-acid-supplementation-affects-tryptophan-metabolism-during-a-12-week-endurance-training-in-amateur-runners-a-randomized-controlled-trial
#5
RANDOMIZED CONTROLLED TRIAL
Maja Tomczyk, Monika Bidzan-Wiącek, Jakub Antoni Kortas, Magdalena Kochanowicz, Zbigniew Jost, Helena L Fisk, Philip C Calder, Jędrzej Antosiewicz
The effects of long-term omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation during endurance training on tryptophan (Trp) metabolism and mental state of healthy individuals have not been evaluated so far. Concentrations of plasma Trp, its metabolites and IL-6 were assessed in 26 male runners before and after a 12-week training program combined with supplementation of n-3 PUFAs (O-3 + TRAIN group) or medium chain triglycerides (MCTs; TRAIN group). After the 12-week program participants' mood before and after stress induction was also assessed...
February 19, 2024: Scientific Reports
https://read.qxmd.com/read/38371504/optimal-omegas-barriers-and-novel-methods-to-narrow-omega-3-gaps-a-narrative-review
#6
REVIEW
Emma J Derbyshire, Catherine S Birch, Graham A Bonwick, Ashley English, Phil Metcalfe, Weili Li
Dietary intakes of omega-3 long chain polyunsaturated fatty acids (O3LC-PUFAs) such as eicosapentaenoic and docosahexaenoic acid are central to development and health across the life course. O3LC-PUFAs have been linked to neurological development, maternal and child health and the etiology of certain non-communicable diseases including age-related cognitive decline, cardiovascular disease, and diabetes. However, dietary inadequacies exist in the United Kingdom and on a wider global scale. One predominant dietary source of O3LC-PUFAs is fish and fish oils...
2024: Frontiers in Nutrition
https://read.qxmd.com/read/38354604/omega-3-fatty-acid-supply-in-pregnancy-for-risk-reduction-of-preterm-and-early-preterm-birth-a-position-statement-by-the-european-board-and-college-of-obstetrics-and-gynaecology-ebcog
#7
JOURNAL ARTICLE
Charles Savona-Ventura, Tahir Mahmood, Sambit Mukhopadhyay, Frank Louwen
Pre-term birth is associated with significant neonatal morbidity and mortality. Pre-term births are associated with significant health and neuro-developmental risks in childhood and adulthood. Women with multiple pregnancies are at much higher risks. Low levels of omega-3 long-chain polyunsaturated fatty acids (PUFAs), such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are associated with higher risk of pre-term labour and increased consumption of foods rich in omega-3 PUFA or supplements are associated with a 11 % and 42 % risk reduction of early and late preterm births, respectively...
February 6, 2024: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://read.qxmd.com/read/38254657/exploring-omega-3-s-impact-on-the-expression-of-bone-related-genes-in-meagre-argyrosomus-regius
#8
JOURNAL ARTICLE
Leticia Luján-Amoraga, Belén Delgado-Martín, Cátia Lourenço-Marques, Paulo J Gavaia, Jimena Bravo, Narcisa M Bandarra, David Dominguez, Marisol S Izquierdo, Pedro Pousão-Ferreira, Laura Ribeiro
Dietary supplementation with Omega-3 fatty acids seems to promote skeletal health. Therefore, their consumption at imbalanced or excessive levels has offered less beneficial or even prejudicial effects. Fish produced in aquaculture regimes are prone to develop abnormal skeletons. Although larval cultures are usually fed with diets supplemented with Omega-3 Long Chain Polyunsaturated fatty acids (LC-PUFAs), the lack of knowledge about the optimal requirements for fatty acids or about their impact on mechanisms that regulate skeletal development has impeded the design of diets that could improve bone formation during larval stages when the majority of skeletal anomalies appear...
December 31, 2023: Biomolecules
https://read.qxmd.com/read/38224465/effects-of-omega-3-omega-6-and-total-dietary-polyunsaturated-fatty-acid-supplementation-in-patients-with-atherosclerotic-cardiovascular-disease-a-systematic-review-and-meta-analysis
#9
JOURNAL ARTICLE
Siqi Luo, Hongmei Hou, Yongjin Wang, Yun Li, Le Zhang, Hui Zhang, Qingzhe Jin, Gangcheng Wu, Xingguo Wang
Background : Uncertainty exists about the link between omega-3 fatty acid, omega-6 fatty acid, and total polyunsaturated fatty acid (PUFA) intake and mortality in atherosclerotic cardiovascular disease (ASCVD) patients, and no meta-analyses summarize the relationship between these various types of PUFAs and ASCVD. Methods : Web of Science, PubMed, EBSCO and Cochrane Library up to November 30, 2022 were searched for prospective randomized controlled studies investigating the relationships among omega-3, omega-6, and PUFA intake and mortality and cardiovascular events in ASCVD patients...
January 15, 2024: Food & Function
https://read.qxmd.com/read/38145766/fine-tuning-of-key-parameters-to-enhance-biomass-and-nutritional-polyunsaturated-fatty-acids-production-from-thraustochytrium-sp
#10
JOURNAL ARTICLE
Ajeet Singh Chauhan, Anil Kumar Patel, Reeta Rani Singhania, Akash Pralhad Vadrale, Chiu-Wen Chen, Balendu Sheker Giri, Jo-Shu Chang, Cheng-Di Dong
The escalating demand for long-chain polyunsaturated fatty acids (PUFAs) due to their vital health effects has deepened the exploration of sustainable sources. Thraustochytrium sp. stands out as a promising platform for omega-3 and 6 PUFA production. This research strategically optimizes key parameters: temperature, salinity, pH, and G:Y:P ratio and the optimized conditions for maximum biomass, total lipid, and DHA enhancement were 28 °C, 50 %, 6, and 10:1:2 respectively. Process optimization enhanced 32...
December 23, 2023: Bioresource Technology
https://read.qxmd.com/read/38134960/effect-of-fatty-acid-profiles-in-varying-recipes-of-ready-to-use-therapeutic-foods-on-neurodevelopmental-and-clinical-outcomes-of-children-6-59-months-with-severe-wasting-a-systematic-review
#11
JOURNAL ARTICLE
Arista Nienaber, Cornelia Conradie, Geoffrey Manda, Bernadette Chimera-Khombe, Ettienne Nel, Edith B Milanzi, Robin C Dolman-Macleod, Martani J Lombard
CONTEXT: In 2020, 13.6 million children under 5 years suffered from severe acute malnutrition (SAM)/wasting. Standard ready-to-use therapeutic foods (RUTFs) improve polyunsaturated fatty acid (PUFA) status but contain suboptimal amounts of omega-3 (n-3) PUFAs with unbalanced n-6-to-n-3 PUFA ratios. OBJECTIVES: The aim was to compare the effects of RUTFs with different essential fatty acid contents on PUFA status, neurodevelopmental, and clinical outcomes (mortality, comorbidities, and recovery) of children with severe wasting...
December 22, 2023: Nutrition Reviews
https://read.qxmd.com/read/38126230/alternative-sources-of-bioactive-omega-3-fatty-acids-what-are-the-options
#12
JOURNAL ARTICLE
Ella J Baker
PURPOSE OF REVIEW: The very-long chain (VLC) omega-3 polyunsaturated fatty acids (PUFAs) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) promote optimal development, physiological function and healthy ageing and help to manage disease. EPA and DHA are sourced mainly from fish, which is not sustainable. This review explores alternative sustainable sources. RECENT FINDINGS: Recent research confirms that higher intake and status of EPA and DHA are associated with health benefits including lower risk of incident type-2 diabetes and cardiovascular disease mortality...
December 8, 2023: Current Opinion in Clinical Nutrition and Metabolic Care
https://read.qxmd.com/read/38123036/genomic-analysis-in-the-colon-tissues-of-omega-3-fatty-acid-treated-rats-identifies-novel-gene-signatures-implicated-in-ulcerative-colitis
#13
JOURNAL ARTICLE
Jhansi Magisetty, Bhavani Gadiraju, Vijay Kondreddy
Several long-term intervention trials only studied the ex vivo immunological function to elucidate the beneficial mechanisms of n-3 polyunsaturated fatty acids (PUFA) in the ulcerative colitis (UC). An unbiased whole-transcriptome analysis would be more valuable to obtain a comprehensive understanding of the processes and genes regulated by n-3 PUFA in vivo. In this study, we have performed microarray analysis in the colon tissues of dextran sulfate sodium (DSS)-induced UC in rats supplemented with n-6 PUFA, n-3PUFA and long-chain n-3PUFA (LC-n3PUFA)...
February 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38111048/central-activation-of-the-fatty-acid-sensor-gpr120-suppresses-microglia-reactivity-and-alleviates-sickness-and-anxiety-like-behaviors
#14
JOURNAL ARTICLE
Shingo Nakajima, Geneviève Demers, Arturo Israel Machuca-Parra, Zahra Dashtehei Pour, Diane Bairamian, Khalil Bouyakdan, Alexandre Fisette, Anita Kabahizi, Josephine Robb, Demetra Rodaros, Cyril Laurent, Guillaume Ferreira, Nathalie Arbour, Thierry Alquier, Stephanie Fulton
G protein-coupled receptor 120 (GPR120, Ffar4) is a sensor for long-chain fatty acids including omega-3 polyunsaturated fatty acids (n-3 PUFAs) known for beneficial effects on inflammation, metabolism, and mood. GPR120 mediates the anti-inflammatory and insulin-sensitizing effects of n-3 PUFAs in peripheral tissues. The aim of this study was to determine the impact of GPR120 stimulation on microglial reactivity, neuroinflammation and sickness- and anxiety-like behaviors by acute proinflammatory insults. We found GPR120 mRNA to be enriched in  both murine and human microglia, and in situ hybridization revealed GPR120 expression in microglia of the nucleus accumbens (NAc) in mice...
December 19, 2023: Journal of Neuroinflammation
https://read.qxmd.com/read/38110038/fish-consumption-and-omega-3-polyunsaturated-fatty-acids-from-diet-are-positively-associated-with-cognitive-function-in-older-adults-even-in-the-presence-of-exposure-to-lead-cadmium-selenium-and-methylmercury-a-cross-sectional-study-using-nhanes-2011-2014-data
#15
JOURNAL ARTICLE
Nozomi Sasaki, Laura E Jones, David O Carpenter
BACKGROUND: Long-chain omega-3 polyunsaturated fatty acids (ω-3 PUFAs) are reported to be beneficial for cognition, but limited consumption of some fish is recommended due to high concentrations of heavy metals and persistent organics. OBJECTIVE: We investigated aimed to determine whether dietary ω-3 PUFAs from fish consumption is associated with higher cognitive scores in older adults and explored the associations of mixtures of ω-3 PUFAs and blood concentrations of lead, cadmium, selenium, and methylmercury on cognitive performance...
December 16, 2023: American Journal of Clinical Nutrition
https://read.qxmd.com/read/38068777/health-benefits-of-oily-fish-illustrated-with-blue-shark-prionace-glauca-shortfin-mako-shark-isurus-oxyrinchus-and-swordfish-xiphias-gladius
#16
REVIEW
Franklin Chamorro, Paz Otero, Maria Carpena, Maria Fraga-Corral, Javier Echave, Sepidar Seyyedi-Mansour, Lucia Cassani, Miguel A Prieto
Oily fish is a rich source of energy, proteins, essential amino acids, lipids, vitamins, and minerals. Among the macronutrients with the highest contribution are lipids, mainly long-chain omega 3 polyunsaturated fatty acids (ω-3 LC-PUFA), especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Both EPA and DHA play a beneficial role in promoting health and preventing many diseases, including cardiovascular diseases, such as stroke and acute myocardial infarction. They also contribute to the prevention of neurological, metabolic, and immune-system-related diseases, as well as supporting body-weight control...
November 25, 2023: Nutrients
https://read.qxmd.com/read/38040326/omega-3-pufa-and-the-fitness-and-cognition-of-the-nematode-caenorhabditis-elegans-under-different-environmental-conditions
#17
JOURNAL ARTICLE
Ralph Menzel, Xuchao Zhang, Tamara Pietrucik, Antonia Bathelt, Liliane Ruess
Many invertebrate species possess the metabolic ability to synthesize long-chain ω3 polyunsaturated fatty acids (PUFA) de novo. Due to their diverse effects on membrane architecture, neuroplasticity, growth and reproduction, PUFA have a high potential to positively influence the fitness of an organism. But how and when do these supposed advantages actually come into play? Other species, that are often closely related, pass natural selection without this special metabolic ability. The ω3-PUFA rich model organism Caenorhabditis elegans (Nematoda) and its mutant fat-1(wa9), lacking these PUFA, are a suitable test system...
November 29, 2023: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://read.qxmd.com/read/37993501/the-role-of-polyunsaturated-fatty-acids-in-the-neurobiology-of-major-depressive-disorder-and-suicide-risk
#18
REVIEW
M Elizabeth Sublette, Federico Manuel Daray, Licínia Ganança, Saame Raza Shaikh
Long-chain polyunsaturated fatty acids (LC-PUFAs) are obtained from diet or derived from essential shorter-chain fatty acids, and are crucial for brain development and functioning. Fundamentally, LC-PUFAs' neurobiological effects derive from their physicochemical characteristics, including length and double bond configuration, which differentiate LC-PUFA species and give rise to functional differences between n(omega)-3 and n-6 LC-PUFAs. LC-PUFA imbalances are implicated in psychiatric disorders, including major depression and suicide risk...
November 22, 2023: Molecular Psychiatry
https://read.qxmd.com/read/37932697/differential-expressions-of-fasn-scd-and-fabp4-genes-in-the-ribeye-muscle-of-omega-3-oil-supplemented-tattykeel-australian-white-lambs
#19
JOURNAL ARTICLE
John Roger Otto, Shedrach Benjamin Pewan, Richard Crawford Edmunds, Felista Waithira Mwangi, Robert Tumwesigye Kinobe, Oyelola Abdulwasiu Adegboye, Aduli Enoch Othniel Malau-Aduli
BACKGROUND: The concept of the functional nutritional value of health-beneficial omega-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFA) is becoming a phenomenon among red meat consumers globally. This study examined the expressions of three lipogenic genes (fatty acid binding protein 4, FABP4, fatty acid synthase, FASN; and stearoyl-CoA desaturase, SCD) in the ribeye (Longissimus thoracis et lumborum) muscle of Tattykeel Australian White (TAW) lambs fed fortified omega-3 diets and correlations with fatty acids...
November 6, 2023: BMC Genomics
https://read.qxmd.com/read/37863453/effects-of-marine-derived-n-3-pufa-supplementation-on-soluble-adhesion-molecules-a-systematic-review-and-dose-response-meta-analysis-of-randomized-controlled-trials
#20
JOURNAL ARTICLE
Mahsa Shirani, Shokoofeh Talebi, Omid Sadeghi, Shirin Hassanizadeh, Gholamreza Askari, Mohammad Bagherniya, Amirhossein Sahebkar
Long-chain n-3 poly unsaturated fatty acids have anti-inflammatory effects but their effects on serum levels of adhesion molecules are inconsistent and contradictory. In this updated systematic review and meta-analysis, marine sources of omega-3 fatty acids were pooled up to determine the effects of omega-3 supplementation on adhesion molecules. PubMed-Medline, SCOPUS, Web of Science and Google Scholar databases (from inception to April 2023) were searched and all RCTs investigating the effects of marine sources of omega-3, on blood concentrations of adhesion molecules were included and a meta-analysis undertaken...
October 18, 2023: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
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