Emma J Thompson, Samantha Escarbe, Denis Tvorogov, Gelareh Farshid, Philip A Gregory, Yeesim Khew-Goodall, Stephen Madden, Wendy V Ingman, Geoffrey J Lindeman, Elgene Lim, Angel F Lopez, Claudine S Bonder
Breast cancer represents a collection of pathologies with different molecular subtypes, histopathology, risk factors, clinical behavior, and responses to treatment. "Basal-like" breast cancers predominantly lack the receptors for estrogen and progesterone (ER/PR), lack amplification of human epidermal growth factor receptor 2 (HER2) but account for 10-15% of all breast cancers, are largely insensitive to targeted treatment and represent a disproportionate number of metastatic cases and deaths. Analysis of interleukin (IL)-3 and the IL-3 receptor subunits ( IL-3RA + CSF2RB ) reveals elevated expression in predominantly the basal-like group...
February 1, 2024: Growth Factors