keyword
https://read.qxmd.com/read/38299881/interleukin-3-production-by-basal-like-breast-cancer-cells-is-associated-with-poor-prognosis
#21
JOURNAL ARTICLE
Emma J Thompson, Samantha Escarbe, Denis Tvorogov, Gelareh Farshid, Philip A Gregory, Yeesim Khew-Goodall, Stephen Madden, Wendy V Ingman, Geoffrey J Lindeman, Elgene Lim, Angel F Lopez, Claudine S Bonder
Breast cancer represents a collection of pathologies with different molecular subtypes, histopathology, risk factors, clinical behavior, and responses to treatment. "Basal-like" breast cancers predominantly lack the receptors for estrogen and progesterone (ER/PR), lack amplification of human epidermal growth factor receptor 2 (HER2) but account for 10-15% of all breast cancers, are largely insensitive to targeted treatment and represent a disproportionate number of metastatic cases and deaths. Analysis of interleukin (IL)-3 and the IL-3 receptor subunits ( IL-3RA + CSF2RB ) reveals elevated expression in predominantly the basal-like group...
February 1, 2024: Growth Factors
https://read.qxmd.com/read/38294185/distinct-patterns-of-cytokines-chemokines-and-growth-factors-in-synovial-fluid-after-acl-injury-in-comparison-to-osteoarthritis
#22
JOURNAL ARTICLE
Muhammad Farooq Rai, Lei Cai, Nobuaki Chinzei, Eric J Schmidt, Omer Yousuf, Farshid Guilak, Robert H Brophy
This study analyzed knee synovial fluid after anterior cruciate ligament (ACL) tear and in osteoarthritis (OA) to test the hypotheses that concentrations of cytokines, chemokines, and growth factors differ (a) by diagnosis and (b) after ACL tear by time from injury and presence/absence of concomitant meniscus tear. Synovial fluid samples were collected from two groups, ACL tears (with or without meniscus tear) (N = 13) and Kellgren-Lawrence grade 3 and 4 OA (N = 16), undergoing clinically indicated aspiration of the knee joint...
January 31, 2024: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/38292513/developing-a-model-to-predict-neonatal-respiratory-distress-syndrome-and-affecting-factors-using-data-mining-a-cross-sectional-study
#23
JOURNAL ARTICLE
Parisa Farshid, Kayvan Mirnia, Peyman Rezaei-Hachesu, Elham Maserat, Taha Samad-Soltani
Background: One of the major challenges that hospitals and clinicians face is the early identification of newborns at risk for adverse events. One of them is neonatal respiratory distress syndrome (RDS). RDS is the widest spared respiratory disorder in immature newborns and the main source of death among them. Machine learning has been broadly accepted and used in various scopes to analyze medical information and is very useful in the early detection of RDS. Objective: This study aimed to develop a model to predict neonatal RDS and affecting factors using data mining...
November 2023: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://read.qxmd.com/read/38291089/degradation-of-2-4-dinitrotoluene-in-aqueous-solution-by-dielectric-barrier-discharge-plasma-combined-with-fe-rgo-bivo-4-nanocomposite
#24
JOURNAL ARTICLE
Yaser Vaziri, Ghorban Asgari, Farshid Ghorbani-Shahna, Tayyebeh Madrakian, Reza Shokoohi, Abdolmotaleb Seid-Mohammadi
2,4-Dinitrotoluene (2,4-DNT) as a priority and hazardous pollutant, is widely used in industrial and military activities. In this study the synergistic effect of Fe-RGO-BiVO4 nanocomposite in a non-thermal dielectric barrier discharge plasma reactor (NTP-DBD) for degrading 2,4-DNT was evaluated. Preparation of the Fe-RGO-BiVO4 nanocomposite was done by a stepwise chemical method depositing Fe and reduced graphene oxide (RGO) on BiVO4 . Field emission scanning electron microscopy (FESEM), X-ray diffraction analysis (XRD), UV-vis diffuse reflectance spectra (DRS), and energy-dispersive X-ray spectroscopy mapping (EDS-mapping) validated the satisfactory synthesis of Fe-RGO-BiVO4 ...
January 30, 2024: Scientific Reports
https://read.qxmd.com/read/38288016/the-effect-of-iranian-snake-naja-naja-oxiana-venom-on-the-blood-glucose-concentration-and-some-biochemical-parameters-of-experimental-diabetic-rats
#25
JOURNAL ARTICLE
Shiva Shahdadi, Farshid Hamidi, Behrooz Fathi
Diabetes is a chronic disease resulting from impaired insulin production and function; leading to hyperglycaemia and long-term complications. The treatment for Type I diabetes treatment involves insulin injections while Type II diabetes treatments include drugs such as metformin and sulfonylureas, along with lifestyle changes. These medicines can be expensive and may have adverse effects. Therefore, the search for new therapeutic agents continues. Venoms from various animals yield numerous pharmacologically active compounds...
January 30, 2024: Heliyon
https://read.qxmd.com/read/38277055/regional-therapy-approaches-for-gastric-cancer-with-limited-peritoneal-disease
#26
REVIEW
Amy Y Li, Shaina Sedighim, Fatemeh Tajik, Aaqil M Khan, Vinodh K Radhakrishnan, Farshid Dayyani, Maheswari Senthil
PURPOSE: Despite advances in systemic therapy, outcomes of patients with gastric cancer (GC) peritoneal carcinomatosis (PC) remain poor, in part because of poor penetrance of systemic therapy into peritoneal metastasis due to the plasma-peritoneal barrier and anarchic intra-tumoral circulation. Hence, regional treatment approach with administration of chemotherapy directly into the peritoneal cavity (intraperitoneal, IP) under various conditions, combined with or without cytoreductive surgery (CRS) has remained an area of significant research interest...
January 26, 2024: Journal of Gastrointestinal Cancer
https://read.qxmd.com/read/38268301/a-concept-analysis-of-transitional-care-for-people-with-cancer
#27
REVIEW
Abbas Mardani, Maryam Azizi, Farshid Alazmani Noodeh, Azizeh Alizadeh, Maryam Maleki, Mojtaba Vaismoradi, Manela Glarcher
AIM: Transitional care as the journey between different caregivers in multiple healthcare centres is crucial for the provision of care to people with cancer, but it is often complex and poorly coordinated. This study aimed to analyse the concept of transitional care for people with cancer. DESIGN: Rodgers' evolutionary concept analysis. METHODS: A systematic literature search was conducted on the databases of PubMed (including MEDLINE), EMBASE, Scopus and Web of Science to retrieve articles published between 2000 and 2022...
January 2024: Nursing Open
https://read.qxmd.com/read/38266879/adsorption-optimization-and-modeling-of-hg-2-ions-from-aqueous-solutions-using-response-surface-methodology-by-snps-cs-bionanocomposite-produced-from-rice-husk-agro-industrial-waste-as-a-novel-environmentally-friendly-bionanoadsorbent
#28
JOURNAL ARTICLE
Soran Kamari, Afsaneh Shahbazi, Farshid Ghorbani
In the present research, extraction of silica (SiO2 ) from rice husk (RH) was optimized and silica nanoparticles (SNPs) was produced using it and functionalized by chitosan (CS) functional groups to obtain CS functionalized SNPs (SNPs-CS) bionanocomposite for the first time. The physical and chemical characteristics of the produced materials were examined using structural analyses. The results of structural analyses confirmed the fine structure of the produced materials. The SNPs-CS bionanocomposite was applied to effectively remove Hg2+ ions from aqueous solutions as an environmentally-friendly bionanoadsorbent and optimization and modeling of the adsorption conditions was explored using designed experiments by Design-Expert software with central composite design (CCD) and response surface methodology (RSM)...
January 22, 2024: Chemosphere
https://read.qxmd.com/read/38252326/-call-for-special-issue-papers-special-issue-on-prof-kyriacos-athanasiou-in-celebration-of-lifetime-achievement-award-from-termis-am
#29
JOURNAL ARTICLE
Michael Detamore, Farshid Guilak, Gabriela Espinosa, Jerry Hu
No abstract text is available yet for this article.
January 2024: Tissue Engineering. Part A
https://read.qxmd.com/read/38247007/application-of-cold-argon-plasma-on-germination-root-length-and-decontamination-of-soybean-cultivars
#30
JOURNAL ARTICLE
Khadijeh Sayahi, Amir Hossein Sari, Aidin Hamidi, Bahareh Nowruzi, Farshid Hassani
Applying cold discharge plasma can potentially alter plants' germination characteristics by triggering their physiological activities. As a main crop in many countries, soybean was examined in the present study using cultivars such as Arian, Katoul, Saba, Sari, and Williams in a cold argon plasma. This study has been motivated by the importance of plant production worldwide, considering climate change and the increasing needs of human populations for food. This study was performed to inspect the effect of cold plasma treatment on seed germination and the impact of argon plasma on microbial decontamination was investigated on soybeans...
January 22, 2024: BMC Plant Biology
https://read.qxmd.com/read/38245535/programmable-integrated-photonics-for-topological-hamiltonians
#31
JOURNAL ARTICLE
Mehmet Berkay On, Farshid Ashtiani, David Sanchez-Jacome, Daniel Perez-Lopez, S J Ben Yoo, Andrea Blanco-Redondo
A variety of topological Hamiltonians have been demonstrated in photonic platforms, leading to fundamental discoveries and enhanced robustness in applications such as lasing, sensing, and quantum technologies. To date, each topological photonic platform implements a specific type of Hamiltonian with inexistent or limited reconfigurability. Here, we propose and demonstrate different topological models by using the same reprogrammable integrated photonics platform, consisting of a hexagonal mesh of silicon Mach-Zehnder interferometers with phase shifters...
January 20, 2024: Nature Communications
https://read.qxmd.com/read/38240782/effects-of-linalool-on-postoperative-peritoneal-adhesions-in-rats
#32
JOURNAL ARTICLE
Farshid Davoodi, Saeed Azizi, Safiyeh Aghazadeh, Omid Dezfoulian
The current study examines the effects of linalool in preventing postoperative abdominal adhesions. Twenty male Wistar rats were randomly divided into four groups. (1) Sham: in this group, the abdomen was approached, and without any manipulations, it was sutured. (2) Control: rats in this group underwent a surgical procedure to induce adhesions. This involved making three incisions on the right abdominal side and removing a 1×1-cm piece of the peritoneum on the left abdominal side. (3) Treatment groups: these groups underwent the same surgical procedure as the control group to induce adhesions...
January 19, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38233430/road-networks-and-socio-demographic-factors-to-explore-covid-19-infection-during-its-different-waves
#33
JOURNAL ARTICLE
Shahadat Uddin, Arif Khan, Haohui Lu, Fangyu Zhou, Shakir Karim, Farshid Hajati, Mohammad Ali Moni
The COVID-19 pandemic triggered an unprecedented level of restrictive measures globally. Most countries resorted to lockdowns at some point to buy the much-needed time for flattening the curve and scaling up vaccination and treatment capacity. Although lockdowns, social distancing and business closures generally slowed the case growth, there is a growing concern about these restrictions' social, economic and psychological impact, especially on the disadvantaged and poorer segments of society. While we are all in this together, these segments often take the heavier toll of the pandemic and face harsher restrictions or get blamed for community transmission...
January 18, 2024: Scientific Reports
https://read.qxmd.com/read/38224427/multi-center-retrospective-review-of-vitiligo-like-lesions-in-breast-cancer-patients-treated-with-cyclin-dependent-kinase-4-and-6-inhibitors
#34
JOURNAL ARTICLE
Alexander S Bang, Christopher J Fay, Nicole R LeBoeuf, Farshid Etaee, Jonathan S Leventhal, Vincent Sibaud, Joshua Arbesman, Jennifer Y Wang, Bernice Y Kwong
PURPOSE: Cutaneous adverse effects from cyclin-dependent 4 and 6 kinase inhibitors (CDK4/6i) used in metastatic breast cancer are prevalent and well described. Vitiligo-like lesions have been reported and are rare. They can negatively impact patients' quality of life and may be associated with survival benefits. We describe the clinical characteristics of vitiligo-like lesions in an international cohort of patients treated with CDK4/6i to help improve recognition and management. METHODS: Retrospective review of patients diagnosed with vitiligo-like lesions from CDK4/6i from five academic institutions in the USA and Europe was performed...
January 15, 2024: Breast Cancer Research and Treatment
https://read.qxmd.com/read/38206784/a-biomechanics-aware-robot-assisted-steerable-drilling-framework-for-minimally-invasive-spinal-fixation-procedures
#35
JOURNAL ARTICLE
Susheela Sharma, Yuewan Sun, Jeff Bonyun, Mohsen Khadem, Jordan Amadio, Amir Hossein Eskandari, Farshid Alambeigi
In this paper, we propose a novel biomechanics-aware robot-assisted steerable drilling framework with the goal of addressing common complications of spinal fixation procedures occurring due to the rigidity of drilling instruments and implants. This framework is composed of two main unique modules to design a robotic system including (i) a Patient-Specific Biomechanics-aware Trajectory Selection Module used to analyze the stress and strain distribution along an implanted pedicle screw in a generic drilling trajectory (linear and/or curved) and obtain an optimal trajectory; and (ii) a complementary semi-autonomous robotic drilling module that consists of a novel Concentric Tube Steerable Drilling Robot (CT-SDR) integrated with a seven degree-of-freedom robotic manipulator...
January 11, 2024: IEEE Transactions on Bio-medical Engineering
https://read.qxmd.com/read/38195494/effectiveness-of-theory-based-educational-interventions-of-promoting-oral-health-among-elementary-school-students
#36
JOURNAL ARTICLE
Samane Shirahmadi, Saeed Bashirian, Ali Reza Soltanian, Akram Karimi-Shahanjarini, Farshid Vahdatinia
BACKGROUND: The aim of the present study was to determine the effect of oral health education programs on the oral health of primary school students. METHODS: In this randomized controlled trial study, 190 elementary fifth-grade female students were chosen using the multistage cluster sampling method. In this study, the Plaque Index (PI), Simplified Oral Hygiene Index (OHI-S), Community Periodontal Index (CPI), tooth brushing using fluoride toothpaste, dental flossing frequency and factors affecting them were determined according to social cognitive theory (SCT)...
January 9, 2024: BMC Public Health
https://read.qxmd.com/read/38194408/a-novel-dual-layer-cascade-reliability-framework-for-an-informed-and-intuitive-clinician-ai-interaction-in-diagnosis-of-colorectal-cancer-polyps
#37
JOURNAL ARTICLE
Siddhartha Kapuria, Patrick Minot, Ariel Kapusta, Naruhiko Ikoma, Farshid Alambeigi
We present a novel Cascade Reliability Framework (CRF) that integrates two independent cascade layers of reliability (i.e., variational temperature scaling and conformal prediction) with a pre-trained Machine Learning (ML) model in order to provide clinicians with a more reliable and tunable tool for early-stage diagnosis of Colorectal Cancer (CRC) polyps. The conformal prediction layer generates predictive sets that are guaranteed to contain the true polyp type with an adjustable error rate tuned by clinicians, while the confidence calibration generates meaningful confidence estimates for each predicted label...
January 9, 2024: IEEE Journal of Biomedical and Health Informatics
https://read.qxmd.com/read/38167985/potential-diagnostic-application-of-a-novel-deep-learning-based-approach-for-covid-19
#38
JOURNAL ARTICLE
Alireza Sadeghi, Mahdieh Sadeghi, Ali Sharifpour, Mahdi Fakhar, Zakaria Zakariaei, Mohammadreza Sadeghi, Mojtaba Rokni, Atousa Zakariaei, Elham Sadat Banimostafavi, Farshid Hajati
COVID-19 is a highly communicable respiratory illness caused by the novel coronavirus SARS-CoV-2, which has had a significant impact on global public health and the economy. Detecting COVID-19 patients during a pandemic with limited medical facilities can be challenging, resulting in errors and further complications. Therefore, this study aims to develop deep learning models to facilitate automated diagnosis of COVID-19 from CT scan records of patients. The study also introduced COVID-MAH-CT, a new dataset that contains 4442 CT scan images from 133 COVID-19 patients, as well as 133 CT scan 3D volumes...
January 2, 2024: Scientific Reports
https://read.qxmd.com/read/38166186/mechanobiology-of-hyaluronan-connecting-biomechanics-and-bioactivity-in-musculoskeletal-tissues
#39
REVIEW
Deva D Chan, Farshid Guilak, Robert L Sah, Sarah Calve
Hyaluronan (HA) plays well-recognized mechanical and biological roles in articular cartilage and synovial fluid, where it contributes to tissue structure and lubrication. An understanding of how HA contributes to the structure of other musculoskeletal tissues, including muscle, bone, tendon, and intervertebral discs, is growing. In addition, the use of HA-based therapies to restore damaged tissue is becoming more prevalent. Nevertheless, the relationship between biomechanical stimuli and HA synthesis, degradation, and signaling in musculoskeletal tissues remains understudied, limiting the utility of HA in regenerative medicine...
January 2, 2024: Annual Review of Biomedical Engineering
https://read.qxmd.com/read/38160088/comparative-evaluation-of-different-spinal-stability-metrics
#40
JOURNAL ARTICLE
Amir Hossein Eskandari, Farshid Ghezelbash, Aboulfazl Shirazi-Adl, Christian Larivière
Direct in vivo measurements of spinal stability are not possible, leaving computational estimations (such as dynamic time series and structural analyses) as the feasible option. However, differences between different stability assessment approaches and metrics remain unclear. To explore this, we asked 32 participants to perform 35 cycles of repetitive lifts with and without load (4/2.6 kg for males/females). EMG signals and 3D kinematics were collected via 12 surface electrodes and 17 inertial sensors, and three dynamical stability measures were computed: short and long temporal and conventional maximum Lyapunov exponents (LyE) and maximum Floquet multipliers (FM)...
December 21, 2023: Journal of Biomechanics
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