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Farshid Keshavarzi, Mahnaz Shahrakipoor, Batool Teimoori, Minoo Yaghmaei, Mehrnaz Narooei-Nejad, Ava Rasooli, Saeedeh Salimi
BACKGROUND: Preeclampsia (PE), is a pregnancy-specific complication with the placental origin which associated with altered expression of angiogenic factors. Vascular Endothelial Growth Factor (VEGF), is a growth and hypoxia-induced factor which contributes to the regulation of various processes. The present study has investigated the association of the placental VEGF -634G/C (rs2010963), -1154G/A (rs1570360), and -2549 I/D (18bpindel) polymorphisms in the promoter region with VEGF mRNA expression in PE women and control group...
May 17, 2018: Clinical and Experimental Hypertension: CHE
John T Martin, Sarah E Gullbrand, Aaron J Fields, Devina Purmessur, Ashish D Diwan, Thomas R Oxland, Kazuhiro Chiba, Farshid Guilak, Judith A Hoyland, James C Iatridis
This study investigated current trends in spine publications of the membership of Orthopaedic Research Society Spine Section (ORS3) and the more global and clinically focused International Society for the Study of the Lumbar Spine (ISSLS). The PubMed database was probed to quantify trends in the overall number of articles published, the number of journals these articles were published in, and the number of active scientists producing new manuscripts. We also evaluated trends in flagship spine journals ( Spine , European Spine Journal , and The Spine Journal ) and in the Journal of Orthopaedic Research...
March 2018: JOR spine
Nguyen Phuong Thao Huynh, Jonathan Matthew Brunger, Catherine Claire Gloss, Franklin T Moutos, Charles A Gersbach, Farshid Guilak
Tissue engineering approaches for the repair of osteochondral defects using biomaterial scaffolds and stem cells have remained challenging due to the inherent complexities of inducing cartilage-like matrix and bone-like matrix within the same local environment. Members of the transforming growth factor β (TGFβ) family have been extensively utilized in the engineering of skeletal tissues, but have distinct effects on chondrogenic and osteogenic differentiation of progenitor cells. The goal of this study was to develop a method to direct human bone marrow derived mesenchymal stem cells (MSCs) to deposit either mineralized matrix or a cartilaginous matrix rich in glycosaminoglycan and type II collagen within the same biochemical environment...
May 14, 2018: Tissue Engineering. Part A
Thomas Muley, Vinzent Rolny, Ying He, Birgit Wehnl, Achim Escherich, Arne Warth, Christa Stolp, Marc A Schneider, Hendrik Dienemann, Michael Meister, Felix J Herth, Farshid Dayyani
OBJECTIVES: To determine whether the tumor biomarkers cytokeratin 19 fragment (CYFRA 21-1) and carcinoembryonic antigen (CEA), which are prognostic in early-stage non-small cell lung cancer (NSCLC), can predict which patients benefit from adjuvant chemotherapy (CTx). MATERIALS AND METHODS: Serum samples were collected preoperatively from patients with NSCLC who underwent resection. Samples were retrospectively analyzed for CYFRA 21-1 and CEA via electrochemiluminescence immunoassay...
June 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
Hamid Vatanparast, Farshid Shahabi, Alireza Bahramian, Aliyar Javadi, Reinhard Miller
Hydrophilic silica nanoparticles alone are not surface active. They, however, develop a strong electrostatic interaction with ionic surfactants and consequently affect their surface behavior. We report the interfacial behavior of n-heptane/anionic-surfactant-solutions in the presence of hydrophilic silica nanoparticles. The surfactants are sodium dodecyl sulfate (SDS) and dodecyl benzene sulfonic acid (DBSA), and the diameters of the used particles are 9 and 30 nm. Using experimental tensiometry, we show that nanoparticles retain their non-surface-active nature in the presence of surfactants and the surface activity of surfactant directly increases with the concentration of nanoparticles...
May 8, 2018: Scientific Reports
Habibolah Khazaie, Farshid Eghbali, Houshang Amirian, Mahmoud Reza Moradi, Mohammad Rasoul Ghadami
Background: Presence of attention deficit hyperactivity disorder (ADHD) has a negative effect on the resolution of incontinence; however, there are few studies which investigated the risk factors of nocturnal enuresis (NE) in patients with ADHD. Aims: This study was conducted to investigate the prevalence of NE and its risk factors in children with ADHD. Methods: 331 children, aged 6 to 10 years, diagnosed as having ADHD were enrolled in this study...
February 25, 2018: Shanghai Archives of Psychiatry
Jagadeesh Kumar Venkatesan, Franklin T Moutos, Ana Rey-Rico, Bradley T Estes, Janina Frisch, Gertrud Schmitt, Henning Madry, Farshid Guilak, Magali Cucchiarini
Combining gene therapy approaches with tissue engineering procedures is an active area of translational research for the effective treatment of articular cartilage lesions, especially to target chondrogenic progenitor cells such as those derived from the bone marrow. Here, we evaluated the effect of genetically modifying concentrated human mesenchymal stem cells from bone marrow to induce chondrogenesis by recombinant adeno-associated viral (rAAV) vector gene transfer of the sex-determining region Y-type high-mobility group box 9 (SOX9) factor upon seeding in three-dimensional (3D) woven poly(ε-caprolactone) (PCL) scaffolds that provide mechanical properties mimicking those of native articular cartilage...
May 2, 2018: Human Gene Therapy
Angeline Josiah, Ahmad Farshid
BACKGROUND: Historically, studies of percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) have reported worse outcomes for women. We sought to determine if contemporary PCI techniques eliminate gender differences in PCI outcomes. METHODS: This was a retrospective study of 4776 consecutive patients who underwent PCI for acute coronary syndromes between January 2008 and July 2015. Primary outcomes studied were major adverse cardiovascular events (MACE) and death at 1year...
April 4, 2018: Heart, Lung & Circulation
Stefan Holdenrieder, Rafael Molina, Ling Qiu, Xiuyi Zhi, Sandra Rutz, Christine Engel, Pia Kasper-Sauer, Farshid Dayyani, Catharina M Korse
In squamous cell carcinoma, squamous cell carcinoma antigen levels are often elevated. This multi-center study evaluated the technical performance of a new Elecsys® squamous cell carcinoma assay, which measures serum squamous cell carcinoma antigen 1 and 2 levels in an equimolar manner, and investigated the potential of squamous cell carcinoma antigen for differential diagnosis of cervical, lung, and head and neck squamous cell carcinoma.Assay precision and method comparison experiments were performed across three European sites...
April 2018: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
Alireza Mohammadi, Ali Maleki-Jamshid, Davood Sanooghi, Peiman Brouki Milan, Arash Rahmani, Farshid Sefat, Koorosh Shahpasand, Mansoureh Soleimani, Mehrdad Bakhtiari, Rafie Belali, Faezeh Faghihi, Mohammad Taghi Joghataei, George Perry, Masoud Mozafari
The original version of this article unfortunately contained mistake in the affiliation. Affiliation 1 should be read as "Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran". The original article has been corrected.
April 26, 2018: Molecular Neurobiology
Nicklas Österlund, Yashraj S Kulkarni, Agata D Misiaszek, Cecilia Wallin, Dennis M Krüger, Qinghua Liao, Farshid Mashayekhy Rad, Jüri Jarvet, Birgit Strodel, Sebastian K T S Wärmländer, Leopold L Ilag, Shina C L Kamerlin, Astrid Gräslund
The amphiphilic nature of the amyloid-β (Aβ) peptide associated with Alzheimer's disease facilitates various interactions with biomolecules such as lipids and proteins, with effects on both structure and toxicity of the peptide. Here, we investigate these peptide-amphiphile interactions by experimental and computational studies of Aβ(1-40) in the presence of surfactants with varying physico-chemical properties. Our findings indicate that electrostatic peptide-surfactant interactions are required for co-clustering and structure induction in the peptide and that the strength of the interaction depends on the surfactant net charge...
April 23, 2018: ACS Chemical Neuroscience
Farshid Rezaei, Rashid Jamei, Reza Heidari
Purpose: The aim of the present study was to investigate the chemical properties of wild Tagetes minuta L. (family Astreacea) collected from Northern Iran during the flowering period concerning the chemical combination of the essential oil along with its antioxidant properties and composition of fatty acids. Methods: The essential oil of the plant was extracted by a Clevenger approach and analyzed using gas chromatography-mass spectroscopy (Capillary HP-5ms GC/MS Column). Fatty acid contents of this species as a result of hexane extraction were analyzed by means of gas chromatography (GC-FID) while their phenolic contents were analyzed by high performance liquid chromatography (HPLC-UV)...
March 2018: Advanced Pharmaceutical Bulletin
Amir Rezaie-Dereshgi, Farshid Mohammad-Rafiee
The electrostatic interactions play a crucial role in biological systems. Here we consider an impermeable dielectric molecule in the solvent with a different dielectric constant. The electrostatic free energy in the problem is studied in the Debye-Hückel regime using the analytical Green function that is calculated in the paper. Using this electrostatic free energy, we study the electrostatic contribution to the twist rigidity of a double stranded helical molecule such as a DNA and an actin filament. The dependence of the electrostatic twist rigidity of the molecule to the dielectric inhomogeneity, structural parameters, and the salt concentration is studied...
April 7, 2018: Journal of Chemical Physics
Payam Zarrintaj, Behnaz Bakhshandeh, Mohammad Reza Saeb, Farshid Sefat, Iraj Rezaeian, Mohammad Reza Ganjali, Seeram Ramakrishna, Masoud Mozafari
The science and engineering of biomaterials have improved the human life expectancy. Tissue engineering is one of the nascent strategies with an aim to fulfill this target. Tissue engineering scaffolds are one of the most significant aspects of the recent tissue repair strategies; hence, it is imperative to design biomimetic substrates with suitable features. Conductive substrates can ameliorate the cellular activity through enhancement of cellular signaling. Biocompatible polymers with conductivity can mimic the cells' niche in an appropriate manner...
April 3, 2018: Acta Biomaterialia
Mahdi Aghili, Sarvazad Sotoudeh, Reza Ghalehtaki, Mohammad Babaei, Borna Farazmand, Mohammad-Sadegh Fazeli, Amir Keshvari, Peiman Haddad, Farshid Farhan
PURPOSE: This study aimed to assess complications and outcomes of a new approach, that is, combining short course radiotherapy (SRT), concurrent and consolidative chemotherapies, and delayed surgery. MATERIALS AND METHODS: In this single arm phase II prospective clinical trial, patients with T3-4 or N+ M0 rectal adenocarcinoma were enrolled. Patients who received induction chemotherapy or previous pelvic radiotherapy were excluded. Study protocol consisted of three-dimensional conformal SRT (25 Gy in 5 fractions in 1 week) with concurrent and consolidation chemotherapies including capecitabine and oxaliplatin...
March 2018: Radiation Oncology Journal
Farshid Ghorbani Shanh, Samira Rahimnejad, Abdulrahman Bahrami, Maryam Farhadian
Context: Long-term exposure to volatile organic compounds (VOCs) affects the occupancies health in petrochemical complex. Objectives: The aim of this study is to apply the lifetime cancer risk (LCR) and hazard quotient (HQ) in occupational exposure to estimate the risk of VOCs in petrochemical complexes. Settings and Design: A cross-sectional study was conducted in the petrochemical complex of Iran for a period of 1 year. Materials and Methods: Sorbent tubes were used to obtain air samples from 169 workers at different petrochemical complexes in southern Iran...
September 2017: Indian Journal of Occupational and Environmental Medicine
Mojtaba Khandan, Sedighe Sadeghian-Rizi, Ghadamali Khodarahmi, Farshid Hassanzadeh
A series of novel sorafenib analogues containing a quinoxalinedione ring and amide linker were synthesized. A total of 9 novel compounds in 6 synthetic steps were synthesized. Briefly, the amino group of p-aminophenol was first protected which then followed by O-arylation with 5-chloro-2-nitroaniline to provide compound d . Reduction of the nitro group of compound d and cyclization of the diamine group of compound e with oxalic acid afforded compound f which on deacetylation yeilded compound g . Then compound g was reacted with different acyl halides to afford the target compounds 1h-1p ...
April 2018: Research in Pharmaceutical Sciences
Omid Shahpari, Moslem FallahKezabi, Hamid Hejrati Kalati, Farshid Bagheri, Mohammad H Ebrahimzadeh
Background: Good clinical outcome and return to sport and daily functions after anatomical arthroscopic anterior cruciate ligament (ACL) reconstruction is goal standard in this surgery. but to date, there are different challenging issues between orthopedic surgeons regarding graft selection and surgical techniques. Methods: We retrospectively reviewed the patients who underwent anatomical arthroscopic one bundle ACL reconstruction with quadruple hamstring tendon autograft from 2010 to 2016 in our orthopedic sport medicine center...
March 2018: Archives of Bone and Joint Surgery
Sara Rashid Chehreh Bargh, Abbas Tafakhori, Farimah Masoumi, Farzaneh Rahmani, Mona Ahmadi, Afshin Namdar, Maryam Azimi, Parsova Tavasolian, Sima Habibi, Babak Zamani, Marziyeh Maserrat, Maryam Sadr, Farshid Noorbakhsh, Nima Rezaei
BACKGROUND: Loss of neuroprotective role of CD4+ helper T cells, regulatory T cells, and M2 microglia constitutively results in the rapid neural death in the "rapidly progressive phase" of amyotrophic lateral sclerosis (ALS). AIM: We aimed to investigate relative count of CD4+ and regulatory T lymphocytes and expression level of IL2Ra and FOXP3 genes in peripheral blood mononuclear cells (PBMCs) from patients with ALS. METHOD: We performed a flow cytometric analysis on PBMC from 38 patients with ALS and 32 controls to determine the count of CD4+ and CD4+ CD25+ cells...
March 25, 2018: Irish Journal of Medical Science
Alireza Mohammadi, Ali Maleki-Jamshid, Davood Sanooghi, Peiman Brouki Milan, Arash Rahmani, Farshid Sefat, Koorosh Shahpasand, Mansoureh Soleimani, Mehrdad Bakhtiari, Rafie Belali, Faezeh Faghihi, Mohammad Taghi Joghataei, George Perry, Masoud Mozafari
A neurological disorder is any disorder or abnormality in the nervous system. Among different neurological disorders, Alzheimer's disease (AD) is recognized as the sixth leading cause of death globally. Considerable research has been conducted to find pioneer treatments for this devastating disorder among which cell therapy has attracted remarkable attentions over the last decade. Up to now, targeted differentiation into specific desirable cell types has remained a major obstacle to clinical application of cell therapy...
March 16, 2018: Molecular Neurobiology
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