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https://www.readbyqxmd.com/read/28732996/nanostructured-%C3%AE-type-titanium-alloy-fabricated-by-ultrasonic-nanocrystal-surface-modification
#1
Mehdi Kheradmandfard, Seyed Farshid Kashani-Bozorg, Chang-Lae Kim, Abbas Zarei Hanzaki, Young-Shik Pyoun, Jung-Hyong Kim, Auezhan Amanov, Dae-Eun Kim
The surface of β-type Ti-Nb-Ta-Zr (TNTZ) alloy, which is a promising material for biomedical applications, was treated with the ultrasonic nanocrystal surface modification (UNSM) technique to enhance its hardness. As a result, a gradient nanostructured (GNS) layer was generated in the surface; the microstructure of the top surface layer consisted of nanoscale lamellae with a width of about 60-200nm. In addition, there were lamellar grains consisting of nanostructured subgrains having unclear and wavy boundaries...
November 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28731086/microfluidic-and-nanofluidic-phase-behaviour-characterization-for-industrial-co2-oil-and-gas
#2
REVIEW
Bo Bao, Jason Riordon, Farshid Mostowfi, David Sinton
Microfluidic systems that leverage unique micro-scale phenomena have been developed to provide rapid, accurate and robust analysis, predominantly for biomedical applications. These attributes, in addition to the ability to access high temperatures and pressures, have motivated recent expanded applications in phase measurements relevant to industrial CO2, oil and gas applications. We here present a comprehensive review of this exciting new field, separating microfluidic and nanofluidic approaches. Microfluidics is practical, and provides similar phase properties analysis to established bulk methods with advantages in speed, control and sample size...
July 21, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28728077/comparison-of-spinal-stability-following-motor-control-and-general-exercises-in-nonspecific-chronic-low-back-pain-patients
#3
MohammadBagher Shamsi, Javad Sarrafzadeh, Aliashraf Jamshidi, Navid Arjmand, Farshid Ghezelbash
BACKGROUND: Motor control exercise was claimed to improve spinal stability in patients with chronic non-specific back pain, but to investigate the effectiveness of this exercise, other outcome measures have been used rather than spinal stability itself. The aim of our study is to assess motor control exercise effects on spinal stability using a biomechanical model. METHODS: Fifty-one patients were assigned to either motor control or general exercises. Before and after trainings, participants were tested for spinal stability at seven isometric tasks...
July 8, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28710969/determination-of-urinary-trans-trans-muconic-acid-using-molecularly-imprinted-polymer-in-microextraction-by-packed-sorbent-followed-by-liquid-chromatography-with-ultraviolet-detection
#4
Esmaeel Soleimani, Abdulrahman Bahrami, Abbas Afkhami, Farshid Ghorbani Shahna
trans,trans-Muconic acid (tt-MA) has been introduced as biological exposure index for workers exposed to benzene. In the present study, for the first time, a novel and easy-to-use analytical method based on molecularly imprinted polymer (MIP) in microextraction by packed sorbent (MEPS), followed by high-performance liquid chromatography with ultra-violet detection (MIMEPS-HPLC-UV) was developed to determine tt-MA in urine samples. Fourier transform infrared spectroscopy was used for MIP characterization. The imprinting effect on the MIP was also evaluated...
July 8, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28709229/phenomenology-of-stochastic-exponential-growth
#5
Dan Pirjol, Farshid Jafarpour, Srividya Iyer-Biswas
Stochastic exponential growth is observed in a variety of contexts, including molecular autocatalysis, nuclear fission, population growth, inflation of the universe, viral social media posts, and financial markets. Yet literature on modeling the phenomenology of these stochastic dynamics has predominantly focused on one model, geometric Brownian motion (GBM), which can be described as the solution of a Langevin equation with linear drift and linear multiplicative noise. Using recent experimental results on stochastic exponential growth of individual bacterial cell sizes, we motivate the need for a more general class of phenomenological models of stochastic exponential growth, which are consistent with the observation that the mean-rescaled distributions are approximately stationary at long times...
June 2017: Physical Review. E
https://www.readbyqxmd.com/read/28707358/suppressed-oligodendrocyte-steroidogenesis-in-multiple-sclerosis-implications-for-regulation-of-neuroinflammation
#6
Roobina Boghozian, Brienne A McKenzie, Leina B Saito, Ninad Mehta, William G Branton, JianQiang Lu, Glen B Baker, Farshid Noorbakhsh, Christopher Power
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS). Neurosteroids are reported to exert anti-inflammatory effects in several neurological disorders. We investigated the expression and actions of the neurosteroid, dehydroepiandrosterone (DHEA), and its more stable 3β-sulphated ester, DHEA-S, in MS and associated experimental models. CNS tissues from patients with MS and animals with experimental autoimmune encephalomyelitis (EAE) displayed reduced DHEA concentrations, accompanied by diminished expression of the DHEA-synthesizing enzyme CYP17A1 in oligodendrocytes (ODCs), in association with increased expression of inflammatory genes including interferon (IFN)-γ and interleukin (IL)-1β...
July 14, 2017: Glia
https://www.readbyqxmd.com/read/28706884/cytotoxic-evaluation-of-some-fused-pyridazino-and-pyrrolo-quinazolinones-derivatives-on-melanoma-and-prostate-cell-lines
#7
Golnaz Vaseghi, Elham Jafari, Farshid Hassanzadeh, Shaghayegh Haghjooy-Javanmard, Nasim Dana, Mahmoud Rafieian-Kopaei
BACKGROUND: Quinazolinon as an important class of heterocycles is attractive in medicinal research areas due to their wide range of biological effects. Cytotoxic activities of the quinazolinone derivatives in various cell lines including: HeLa, L1210 (mouse lymphocytic leukemia) and HT29 (human colon adenocarcinoma) were reported. MATERIALS AND METHODS: In this study, a number of newly made tricycles quinazolinone derivatives such as fused pyridazino-quinazolinones and fused pyrrolo-quinazolinones were evaluated on two cancerous cell lines, melanoma (B16F10) and prostate (PC3) using the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide colorimetric assay...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28698151/the-effects-of-methamphetamine-and-buprenorphine-and-their-interaction-on-anxiety-like-behavior-and-locomotion-in-male-rats
#8
Farshid Etaee, Masoumeh Asadbegi, Zahra Taslimi, Siamak Shahidi, Abdolrahman Sarihi, Sara Soleimani Asl, Alireza Komaki
Methamphetamine (Meth) abuse and dependence are major global problems. Most of previous studies showed that Meth is anxiogenic. While buprenorphine (Bup) is used to treat anxiety-related behaviors, the effects of Meth in combination with Bup on anxiety-like behavior are unclear. In this study, we examined the effects of these drugs on anxiety-like behavior with the elevated plus maze (EPM) and open field (OF) tests, which are widely used to assess anxiety-like behavior in small rodents. Forty male Wistar rats were divided into four groups: sham, Meth, Bup, and Bup+Meth...
July 8, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28693181/distinct-dna-methylation-alterations-are-associated-with-cribriform-architecture-and-intraductal-carcinoma-in-gleason-pattern-4-prostate-tumors
#9
Ekaterina Olkhov-Mitsel, Farshid Siadat, Ken Kron, Liyang Liu, Andrea J Savio, John Trachtenberg, Neil Fleshner, Theodorus van der Kwast, Bharati Bapat
The aim of the present study was to explore DNA methylation aberrations in association with cribriform architecture and intraductal carcinoma (IDC) of the prostate, as there is robust evidence that these morphological features are associated with aggressive disease and have significant clinical implications. Herein, the associations of a panel of seven known prognostic DNA methylation biomarkers with cribriform and IDC features were examined in a series of 91 Gleason pattern (GP) 4 tumors derived from Gleason score 7 radical prostatectomies...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28665739/the-placental-vascular-endothelial-growth-factor-polymorphisms-and-preeclampsia-preeclampsia-severity
#10
Farshid Keshavarzi, Abbas Mohammadpour-Gharehbagh, Mahnaz Shahrakipour, Batool Teimoori, Atefeh Yazdi, Minoo Yaghmaei, Mehrnaz Naroeei-Nejad, Saeedeh Salimi
Preeclampsia (PE) is a serious pregnancy-specific condition, which originates from placenta and finishes after delivery. The present study has investigated the association between placental VEGF I/D (rs35569394), -1154G/A (rs1570360), and -634G/C(rs2010963) polymorphisms and maternal VEGF -2549 I/D (rs35569394) polymorphism with PE and PE severity. In this case-control study, the maternal blood of 217 women with PE and 210 normotensive pregnant women and the placenta of 84 PE women and 103 normotensive women were collected after delivery...
June 30, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28664968/direct-visualization-of-fluid-dynamics-in-sub-10-nm-nanochannels
#11
Huawei Li, Junjie Zhong, Yuanjie Pang, Seyed Hadi Zandavi, Aaron Harrinarine Persad, Yi Xu, Farshid Mostowfi, David Sinton
Optical microscopy is the most direct method to probe fluid dynamics at small scales. However, contrast between fluid phases vanishes at ∼10 nm lengthscales, limiting direct optical interrogation to larger systems. Here, we present a method for direct, high-contrast and label-free visualization of fluid dynamics in sub-10 nm channels, and apply this method to study capillary filling dynamics at this scale. The direct visualization of confined fluid dynamics in 8-nm high channels is achieved with a conventional bright-field optical microscope by inserting a layer of a high-refractive-index material, silicon nitride (Si3N4), between the substrate and the nanochannel, and the height of which is accurately controlled down to a few nanometers by a SiO2 spacer layer...
July 13, 2017: Nanoscale
https://www.readbyqxmd.com/read/28663880/three-dimensional-mri-study-of-the-relationship-between-eye-dimensions-retinal-shape-and-myopia
#12
James M Pope, Pavan K Verkicharla, Farshid Sepehrband, Marwan Suheimat, Katrina L Schmid, David A Atchison
We investigated changes in eye dimensions and retinal shape with degree of myopia, gender and race. There were 58 young adult emmetropes and myopes (range -1.25D to -8.25D), with 30 East-Asians (21 female/9 male), 23 Caucasians (16/7) and 5 South-Asians (1/4). Three-dimensional magnetic resonance imaging was undertaken with a 3.0 Tesla whole-body clinical MRI system using a 4.0 cm receive-only surface coil positioned over the eye. Automated methods determined eye length, width and height, and curve fitting procedures determined asymmetric and symmetric ellipsoid shapes to 75%, 55% and 35% of the retina...
May 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28660163/effective-environmental-factors-on-geographical-distribution-of-traffic-accidents-on-pedestrians-downtown-tehran-city
#13
Ali Moradi, Hamid Soori, Amir Kavousi, Farshid Eshghabadi, Shahrzad Nematollahi, Salahdien Zeini
INTRODUCTION: In most countries, occurrence of traffic causalities is high in pedestrians. The aim of this study is to geographically analyze the traffic casualties in pedestrians in downtown Tehran city. METHODS: The study population consisted of traffic injury accidents in pedestrians occurred during 2015 in Tehran city. Data were extracted from offices of traffic police and municipality. For analysis of environmental factors and site of accidents, ordinary least square regression models and geographically weighted regression were used...
April 2017: International Journal of Critical Illness and Injury Science
https://www.readbyqxmd.com/read/28659017/effect-of-tio2-gac-and-water-vapor-on-chloroform-decomposition-in-a-hybrid-plasma-catalytic-system
#14
Abedi Kamal Ad-Din, Ghorbani-Shahna Farshid, Bahrami Abdulrahman, Ebrahimi Hossein, Maleki Afshin, Madjidi Faramarz, Musavi Saeed, Mohammadi Ebrahim, Giahi Omid
This paper presents the combination of TiO2/GAC catalyst and NTP for the decomposition of chloroform using a DBD reactor. The experiments were performed using an AC transformer as the power supply system to determine the optimal conditions of the chloroform conversion in the presence of a hydrogen-rich substance i.e. water vapor. TiO2/GAC enhanced the removal efficiency and also CO2 selectivity significantly, leading to an acceptable conversion rate at SIEs higher than 400 J L(-1). The adsorption property of GAC was noticed to be an effective factor for catalytic activity by increasing the residence time, although the higher retention time prevented the accurate determination of chlorine and carbon balance...
June 29, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28657672/genetic-variants-in-3-utrs-of-mthfr-in-the-pregnancies-complicated-with-preeclampsia-and-bioinformatics-analysis
#15
Abbas Mohammadpour-Gharehbagh, Saeedeh Salimi, Farshid Keshavarzi, Foozieh Saeidian, Mahdieh Mousavi, Batool Teimoori, Maryam Esmaeilipour, Mojgan Mokhtari
Preeclampsia (PE) as a pregnancy-specific disorder is the major cause of mortality and morbidity of mothers and fetuses. This study attempts to investigate the possible association between the 2572C > A (rs4846049) and 4869C > G (rs1537514) polymorphisms in the 3'- untranslated region of MTHFR gene and the risk of PE. A total of 198 patients diagnosed with PE and 171 unrelated, age matched healthy pregnant women, were recruited for this case-control study. The MTHFR 2572C > A and 4869C > G genotyping was performed by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method...
June 28, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28653348/asystole-caused-by-hydroxycut-hardcore-a-case-report-and-literature-review
#16
Julie Zaidan, Rabih Tabet, Boutros Karam, Farshid Daneshvar, Mohammed Raza, Soad Bekheit
Obesity is a rising epidemic worldwide driving people to search for remedy through nonconventional therapies. Hydroxycut products are popular supplements used as weight loss aids. Many reports revealed serious adverse effects related to their ingestion. We report the case of a 37-year-old healthy male patient who presented following an episode of syncope. On telemetry, he manifested recurrent sinus node arrests, including a symptomatic 24 s sinus pause. The patient admitted to taking Hydroxycut Hardcore for 10 days previously...
June 27, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/28626481/quantum-mechanical-molecular-mechanical-and-docking-study-of-the-novel-analogues-based-on-hybridization-of-common-pharmacophores-as-potential-anti-breast-cancer-agents
#17
Parvin Asadi, Ghadamali Khodarahmi, Hossein Farrokhpour, Farshid Hassanzadeh, Lotfollah Saghaei
In an attempt to identify some new potential leads as anti-breast cancer agents, novel hybrid compounds were designed by molecular hybridization approach. These derivatives were structurally derived from hybrid benzofuran-imidazole and quinazolinone derivatives, which had shown good cytotoxicity against the breast cancer cell line (MCF-7). Since aromatase enzyme (CYP19) is highly expressed in the MCF-7 cell line, the binding of these novel hybrid compounds to aromatase was investigated using the docking method...
June 2017: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28617951/altered-expression-of-igf-i-system-in-neurons-of-the-inflamed-spinal-cord-during-acute-experimental-autoimmune-encephalomyelitis
#18
Azita Parvaneh Tafreshi, Farideh Talebi, Samira Ghorbani, Claude Bernard, Farshid Noorbakhsh
BACKGROUND: There is growing evidence that the impaired IGF-I system contributes to neurodegeneration. OBJECTIVES: In this study, we examined the spinal cords of the EAE, the animal model of multiple sclerosis, to see if the expression of the IGF-I system is altered. METHODS: To induce EAE, C57/BL6 mice were immunized with the Hooke lab MOG kit, sacrificed at the peak of the disease and their spinal cords were examined for the immunoreactivities (ir) of the IGF-I, IGF binding protein-1 (IGFBP-1) and glycogen synthase kinase 3β (GSK3β), as one major downstream molecule in the IGF-I signaling...
June 15, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28608760/plga-peg-ra-based-polymeric-micelles-for-tumor-targeted-delivery-of-irinotecan
#19
Jaber Emami, Parnian Maghzi, Farshid Hasanzadeh, Hojjat Sadeghi, Mina Mirian, Mahboubeh Rostami
To develop an effective therapeutic treatment, the potential of poly (lactic-co-glycolic acid)-polyethylene glycol-retinoic acid (PLGA-PEG-RA) polymeric micelles for targeted delivery of irinotecan to hepatocellular carcinoma (HepG2) and colorectal cancer cell lines (HT-29) was evaluated. PLGA-PEG-RA was synthesized by amide reaction of PLGA with NH2-PEG-NH2 and then PLGA-PEG-NH2 with RA and confirmed by FTIR and (1)H NMR spectroscopy. Irinotecan-loaded nanomicelles were prepared using thin-film hydration method and the impact of various formulation variables on their particle size (PS), polydispersity index (PDI), zeta potential (ZP), entrapment efficiency (EE), and mean release time (MRT) were assessed using a Taguchi design...
June 13, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28608245/obesity-and-obesity-shape-markedly-influence-spine-biomechanics-a-subject-specific-risk-assessment-model
#20
Farshid Ghezelbash, Aboulfazl Shirazi-Adl, André Plamondon, Navid Arjmand, Mohamad Parnianpour
Underlying mechanisms of obesity-related back pain remain unexplored. Thus, we aim to determine the effect of obesity and its shapes on the spinal loads and the associated risks of injury. Obesity shapes were initially constructed by principal component analysis based on datasets on 5852 obese individuals. Spinal loads, cycles to vertebral failure and trunk stability margin were estimated in a subject-specific trunk model taking account of personalized musculature, passive ligamentous spine, obesity shapes, segmental weights, spine kinematics and bone mineral density...
June 12, 2017: Annals of Biomedical Engineering
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