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https://www.readbyqxmd.com/read/28337626/application-of-a-novel-magnetic-carbon-nanotube-adsorbent-for-removal-of-mercury-from-aqueous-solutions
#1
Farshid Homayoon, Hossein Faghihian, Firoozeh Torki
In this research, multiwall carbon nanotube was magnetized and subsequently functionalized by thiosemicarbazide. After characterization by FTIR, BET, SEM, EDAX, and VSM techniques, the magnetized adsorbent (multi-walled carbon nanotubes (MWCNTs)/Fe3O4) was used for removal of Hg(2+) from aqueous solutions and the experimental conditions were optimized. The adsorption capacity of 172.83 mg g(-1) was obtained at 25 °C and pH = 3 which was superior to the value obtained for initial multiwall carbon nanotube, magnetized sample, and many previously reported values...
March 23, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28323882/mir-181-interacts-with-signaling-adaptor-molecule-denn-madd-and-enhances-tnf-induced-cell-death
#2
Samira Ghorbani, Farideh Talebi, Sedigheh Ghasemi, Ali Jahanbazi Jahan Abad, Mohammed Vojgani, Farshid Noorbakhsh
MicroRNAs are small noncoding RNAs, which regulate the expression of protein coding transcripts through mRNA degradation or translational inhibition. Numerous reports have highlighted the role of miRNAs in regulating cell death pathways including the expression of genes involved in the induction of apoptosis. Tumor necrosis factor alpha (TNF-α) is a proinflammatory cytokine which can send pro-death signals through its receptor TNFR1. Diverse adaptor molecules including DENN/MADD adaptor protein have been shown to modulate TNF-α pro-death signaling via recruitment of MAP kinases to TNFR1 and activation of pro-survival NFκB signaling...
2017: PloS One
https://www.readbyqxmd.com/read/28317846/serum-and-synovial-fluid-lipidomic-profiles-predict-obesity-associated-osteoarthritis-synovitis-and-wound-repair
#3
Chia-Lung Wu, Kelly A Kimmerling, Dianne Little, Farshid Guilak
High-fat diet-induced obesity is a major risk factor for osteoarthritis (OA) and diminished wound healing. The objective of this study was to determine the associations among serum and synovial fluid lipid levels with OA, synovitis, adipokine levels, and wound healing in a pre-clinical obese mouse model of OA. Male C57BL/6 J mice were fed either a low-fat (10% kcal) or one of three high-fat (HF, 60% kcal) diets rich in saturated fatty acids (SFAs), ω-6 or ω-3 polyunsaturated FAs (PUFAs). OA was induced by destabilization of the medial meniscus...
March 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28302134/microrna-142-regulates-inflammation-and-t-cell-differentiation-in-an-animal-model-of-multiple-sclerosis
#4
Farideh Talebi, Samira Ghorbani, Wing Fuk Chan, Roobina Boghozian, Farimah Masoumi, Sedigheh Ghasemi, Mohammed Vojgani, Christopher Power, Farshid Noorbakhsh
BACKGROUND: MicroRNAs have emerged as an important class of modulators of gene expression. These molecules influence protein synthesis through translational repression or degradation of mRNA transcripts. Herein, we investigated the potential role of miR-142a isoforms, miR-142a-3p and miR-142a-5p, in the context of autoimmune neuroinflammation. METHODS: The expression levels of two mature isoforms of miR-142 were measured in the brains of patients with multiple sclerosis (MS) and the CNS tissues from mice with experimental autoimmune encephalomyelitis (EAE), an animal model of MS...
March 16, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28301499/svip-regulates-z-variant-alpha-1-antitrypsin-retro-translocation-by-inhibiting-ubiquitin-ligase-gp78
#5
Nazli Khodayari, Rejean Liqun Wang, George Marek, Karina Krotova, Mariana Kirst, Chen Liu, Farshid Rouhani, Mark Brantly
Alpha-1 antitrypsin deficiency (AATD) is an inherited disorder characterized by early-onset emphysema and liver disease. The most common disease-causing mutation is a single amino acid substitution (Glu/Lys) at amino acid 342 of the mature protein, resulting in disruption of the 290-342 salt bridge (an electrophoretic abnormality defining the mutation [Z allele, or ZAAT]), protein misfolding, polymerization, and accumulation in the endoplasmic reticulum of hepatocytes and monocytes. The Z allele causes a toxic gain of function, and the E3 ubiquitin ligase gp78 promotes degradation and increased solubility of endogenous ZAAT...
2017: PloS One
https://www.readbyqxmd.com/read/28291148/mechanical-signals-as-regulators-of-cartilage-degeneration-and-regeneration
#6
Muhammad Farooq Rai, Martin J Stoddart, Farshid Guilak
No abstract text is available yet for this article.
April 2017: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/28278517/carcinoembryonic-antigen-and-cytokeratin-19-fragments-for-assessment-of-therapy-response-in-non-small-cell-lung-cancer-a-systematic-review-and-meta-analysis
#7
Stefan Holdenrieder, Birgit Wehnl, Karina Hettwer, Kirsten Simon, Steffen Uhlig, Farshid Dayyani
BACKGROUND: This meta-analysis evaluated whether pretherapy serum levels of carcinoembryonic antigen (CEA) and cytokeratin-19 fragments (CYFRA 21-1) are predictive of response to therapy in non-small cell lung cancer (NSCLC) and whether changes in these markers during vs pretherapy are indicative of response. METHODS: Original peer-reviewed studies enrolling adults with untreated advanced NSCLC were identified using PubMed. Two reviewers independently extracted data from eligible studies and assessed study heterogeneity and the risk of study bias...
March 9, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28274476/new-tools-for-content-innovation-and-data-sharing-enhancing-reproducibility-and-rigor-in-biomechanics-research
#8
Farshid Guilak
We are currently in one of the most exciting times for science and engineering as we witness unprecedented growth in our computational and experimental capabilities to generate new data and models. To facilitate data and model sharing, and to enhance reproducibility and rigor in biomechanics research, the Journal of Biomechanics has introduced a number of tools for Content Innovation to allow presentation, sharing, and archiving of methods, models, and data in our articles. The tools include an Interactive Plot Viewer, 3D Geometric Shape and Model Viewer, Virtual Microscope, Interactive MATLAB Figure Viewer, and Audioslides...
February 10, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28271574/assessing-impact-of-organised-breast-screening-across-small-residential-areas-development-and-internal-validation-of-a-prediction-model
#9
E Buckley, G Farshid, G Gill, J Kollias, B Koczwara, C Karapetis, J Adams, R Joshi, D Keefe, T Niyonsenga, K Powell, K Fusco, M Eckert, K Beckmann, D Roder
Monitoring screening mammography effects in small areas is often limited by small numbers of deaths and delayed effects. We developed a risk score for breast cancer death to circumvent these limitations. Screening, if effective, would increase post-diagnostic survivals through lead-time and related effects, as well as mortality reductions. Linked cancer and BreastScreen data at four hospitals (n = 2,039) were used to investigate whether screened cases had higher recorded survivals in 13 small areas, using breast cancer deaths as the outcome (M1), and a risk of death score derived from TNM stage, grade, histology type, hormone receptor status, and related variables (M2)...
March 7, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28271101/bubble-nucleation-and-growth-in-nanochannels
#10
Bo Bao, Seyed Hadi Zandavi, Huawei Li, Junjie Zhong, Arnav Jatukaran, Farshid Mostowfi, David Sinton
We apply micro- and nanofluidics to study fundamental phase change behaviour at nanoscales, as relevant to shale gas/oil production. We investigate hydrocarbon phase transition in sub-100 nm channels under conditions that mimic the pressure drawdown process. Measured cavitation pressures are compared with those predicted from the nucleation theory. We find that cavitation pressure in the nanochannels corresponds closer to the spinodal limit than that predicted from classical nucleation theory. This deviation indicates that hydrocarbons remain in the liquid phase in nano-sized pores under pressures much lower than the saturation pressure...
March 8, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28269416/toward-robot-assisted-hard-osteolytic-lesion-treatment-using-a-continuum-manipulator
#11
Farshid Alambeigi, Y Wang, Ryan J Murphy, Iulian Iordachita, Mehran Armand
In this paper, we describe the design and fabrication of an actuation unit for controlling a continuum dexterous manipulator (CDM). The actuation unit is attached to a positioning robot and the integrated system provides sufficient dexterity for placement of a proposed flexible cutting tool used for treatment of oseteolysis (bone degradation). Preliminary experiments on simulated osteolytic lesions demonstrated the feasibility of using the novel flexible cutter inside the continuum manipulator. In these experiments, we found an optimal combination of rotational and sweeping speed of the cutter through the lesion...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28261402/cardiorespiratory-fitness-in-internal-medicine-residents-are-future-physicians-becoming-deconditioned
#12
Farshid Daneshvar, Michael Weinreich, Danial Daneshvar, Michael Sperling, Chadi Salmane, Harout Yacoub, James Gabriels, Thomas McGinn, Marianne C Smith
BACKGROUND : Previous studies have shown a falloff in physicians' physical activity from medical school to residency. Poor fitness may result in stress, increase resident burnout, and contribute to mortality from cardiovascular disease and other causes. Physicians with poor exercise habits are also less likely to counsel patients about exercise. Prior studies have reported resident physical activity but not cardiorespiratory fitness age. OBJECTIVE : The study was conducted in 2 residency programs (3 hospitals) to assess internal medicine residents' exercise habits as well as their cardiorespiratory fitness age...
February 2017: Journal of Graduate Medical Education
https://www.readbyqxmd.com/read/28243063/novel-5-oxo-hexahydroquinoline-derivatives-design-synthesis-in-vitro-p-glycoprotein-mediated-multidrug-resistance-reversal-profile-and-molecular-dynamics-simulation-study
#13
Omolbanin Shahraki, Najmeh Edraki, Mehdi Khoshneviszadeh, Farshid Zargari, Sara Ranjbar, Luciano Saso, Omidreza Firuzi, Ramin Miri
Overexpression of the efflux pump P-glycoprotein (P-gp) is one of the important mechanisms of multidrug resistance (MDR) in many tumor cells. In this study, 26 novel 5-oxo-hexahydroquinoline derivatives containing different nitrophenyl moieties at C4 and various carboxamide substituents at C3 were designed, synthesized and evaluated for their ability to inhibit P-gp by measuring the amount of rhodamine 123 (Rh123) accumulation in uterine sarcoma cells that overexpress P-gp (MES-SA/Dx5) using flow cytometry...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28237185/relationship-between-t1rho-magnetic-resonance-imaging-synovial-fluid-biomarkers-and-the-biochemical-and-biomechanical-properties-of-cartilage
#14
Courtney C Hatcher, Amber T Collins, Sophia Y Kim, Lindsey C Michel, William C Mostertz, Sophia N Ziemian, Charles E Spritzer, Farshid Guilak, Louis E DeFrate, Amy L McNulty
Non-invasive techniques for quantifying early biochemical and biomechanical changes in articular cartilage may provide a means of more precisely assessing osteoarthritis (OA) progression. The goals of this study were to determine the relationship between T1rho magnetic resonance (MR) imaging relaxation times and changes in cartilage composition, cartilage mechanical properties, and synovial fluid biomarker levels and to demonstrate the application of T1rho imaging to evaluate cartilage composition in human subjects in vivo...
February 6, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28227659/toward-robot-assisted-hard-osteolytic-lesion-treatment-using-a-continuum-manipulator
#15
Farshid Alambeigi, Y Wang, Ryan J Murphy, Iulian Iordachita, Mehran Armand, Farshid Alambeigi, Y Wang, Ryan J Murphy, Iulian Iordachita, Mehran Armand, Ryan J Murphy, Y Wang, Iulian Iordachita, Mehran Armand, Farshid Alambeigi
In this paper, we describe the design and fabrication of an actuation unit for controlling a continuum dexterous manipulator (CDM). The actuation unit is attached to a positioning robot and the integrated system provides sufficient dexterity for placement of a proposed flexible cutting tool used for treatment of oseteolysis (bone degradation). Preliminary experiments on simulated osteolytic lesions demonstrated the feasibility of using the novel flexible cutter inside the continuum manipulator. In these experiments, we found an optimal combination of rotational and sweeping speed of the cutter through the lesion...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28223859/histatin-peptides-pharmacological-functions-and-their-applications-in-dentistry
#16
REVIEW
Zohaib Khurshid, Shariq Najeeb, Maria Mali, Syed Faraz Moin, Syed Qasim Raza, Sana Zohaib, Farshid Sefat, Muhammad Sohail Zafar
There are many human oral antimicrobial peptides responsible for playing important roles including maintenance, repairing of oral tissues (hard or soft) and defense against oral microbes. In this review we have highlighted the biochemistry, physiology and proteomics of human oral histatin peptides, secreted from parotid and submandibular salivary glands in human. The significance of these peptides includes capability for ionic binding that can kill fungal Candida albicans. They have histidine rich amino acid sequences (7-12 family members; corresponding to residues 12-24, 13-24, 12-25, 13-25, 5-11, and 5-12, respectively) for Histatin-3...
January 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28208685/hollow-fiber-supported-liquid-membrane-extraction-combined-with-hplc-uv-for-simultaneous-preconcentration-and-determination-of-urinary-hippuric-acid-and-mandelic-acid
#17
Abdulrahman Bahrami, Farhad Ghamari, Yadollah Yamini, Farshid Ghorbani Shahna, Abbas Moghimbeigi
This work describes a new extraction method with hollow-fiber liquid-phase microextraction based on facilitated pH gradient transport for analyzing hippuric acid and mandelic acid in aqueous samples. The factors affecting the metabolites extraction were optimized as follows: the volume of sample solution was 10 mL with pH 2 containing 0.5 mol·L(-1) sodium chloride, liquid membrane containing 1-octanol with 20% (w/v) tributyl phosphate as the carrier, the time of extraction was 150 min, and stirring rate was 500 rpm...
February 12, 2017: Membranes
https://www.readbyqxmd.com/read/28202057/improvement-of-memory-and-learning-by-intracerebroventricular-microinjection-of-t3-in-rat-model-of-ischemic-brain-stroke-mediated-by-upregulation-of-bdnf-and-gdnf-in-ca1-hippocampal-region
#18
Tahmineh Mokhtari, Mohammad Akbari, Fatemeh Malek, Iraj Ragerdi Kashani, Tayebeh Rastegar, Farshid Noorbakhsh, Mahmoud Ghazi-Khansari, Fatemeh Attari, Gholamreza Hassanzadeh
BACKGROUND: Ischemic stroke is a common leading cause of death and disability with lack of effective therapies. In this study, T3 was intra-ventricularly injected to evaluate gene expression and protein concentration of and brain-derived neurotrophic factor (BDNF) and Glial cell-derived neurotrophic factor (GDNF) in hippocampal CA1 region in rat model of brain ischemia/reperfusion (I/R). METHODS: In this study, transient middle cerebral artery occlusion (tMCAo) was used as model of ischemic brain stroke...
February 15, 2017: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/28197353/scaphoid-fracture-in-a-patient-with-a-scaphotrapezial-synostosis-a-case-report-and-literature-review
#19
Soliman Noureldin, Mohammed Ali, Farshid Fallahi, Thomas Dehler
Introduction. Scaphotrapezial synostosis has been rarely reported in the literature and only one case underwent surgical treatment for scaphoid fracture. Presentation of Case. A 15-year-old male presented with a painful left wrist following a fall. The initial radiographs showed a displaced scaphoid proximal pole fracture and a Scaphotrapezial synostosis. The fracture was then fixed percutaneously with satisfactory outcome. Discussion. Scaphotrapezial synostoses are very rare and most found in patients with multiple congenital anomalies or as part of a hereditary syndrome...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/28191681/a-time-efficient-acquisition-protocol-for-multipurpose-diffusion-weighted-microstructural-imaging-at-7-tesla
#20
Farshid Sepehrband, Kieran O'Brien, Markus Barth
PURPOSE: Several diffusion-weighted MRI techniques have been developed and validated during the past 2 decades. While offering various neuroanatomical inferences, these techniques differ in their proposed optimal acquisition design, preventing clinicians and researchers benefiting from all potential inference methods, particularly when limited time is available. This study reports an optimal design that enables for a time-efficient diffusion-weighted MRI acquisition scheme at 7 Tesla...
February 12, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
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