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https://www.readbyqxmd.com/read/28549310/segmentation-of-lumen-and-outer-wall-of-abdominal-aortic-aneurysms-from-3d-black-blood-mri-with-a-registration-based-geodesic-active-contour-model
#1
Yan Wang, Florent Seguro, Evan Kao, Yue Zhang, Farshid Faraji, Chengcheng Zhu, Henrik Haraldsson, Michael Hope, David Saloner, Jing Liu
Segmentation of the geometric morphology of abdominal aortic aneurysm is important for interventional planning. However, the segmentation of both the lumen and the outer wall of aneurysm in magnetic resonance (MR) image remains challenging. This study proposes a registration based segmentation methodology for efficiently segmenting MR images of abdominal aortic aneurysms. The proposed methodology first registers the contrast enhanced MR angiography (CE-MRA) and black-blood MR images, and then uses the Hough transform and geometric active contours to extract the vessel lumen by delineating the inner vessel wall directly from the CE-MRA...
May 19, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28544542/conditional-macrophage-depletion-increases-inflammation-and-does-not-inhibit-the-development-of-osteoarthritis-in-obese-mafia-mice
#2
Chia-Lung Wu, Jenna McNeill, Kelsey Goon, Dianne Little, Kelly Kimmerling, Janet Huebner, Virginia Kraus, Farshid Guilak
OBJECTIVE: Macrophages are believed to play a critical role in the inflammation associated with the development of osteoarthritis (OA) in obesity. The objective of the study was to investigate whether short-term, systemic depletion of macrophages would mitigate OA following injury in obese mice. METHODS: CSF-1R-GFP(+) Macrophage Fas-Induced Apoptosis (MaFIA) transgenic mice that allow conditional depletion of macrophages were placed on a high-fat diet and underwent surgery to induce knee OA...
May 23, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28543595/stem-cell-therapy-a-new-therapeutic-option-for-cardiovascular-diseases
#3
Nasser Hashemi Goradel, Farshid Ghiyami SHoor, Babak Negahdari, Ziba Vaisi Malekshahi, Milad Hashemzehi, Aria Masoudifar, Hamed Mirzaei
Cardiovascular diseases are known as one of major causes of morbidity and mortality worldwide. Despite the many advancement in therapies are associated with cardiovascular diseases, it seems that finding of new therapeutic option is necessary. Cell therapy is one of attractive therapeutic platforms for treatment of a variety of diseases such as cardiovascular diseases. Among of various types of cell therapy, stem cell therapy has been emerged as an effective therapeutic approach in this area. Stem cells divided into multipotent stem cells and pluripotent stem cells...
May 25, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28543172/nanoparticles-as-new-tools-for-inhibition-of-cancer-angiogenesis
#4
REVIEW
Nasser Hashemi Goradel, Farshid Ghiyami Hoor, Samira Jahangiri, Babak Negahdari, Amirhossein Sahebkar, Aria Masoudifar, Hamed Mirzaei
Angiogenesis is known as one of the hallmarks of cancer. Multiple lines evidence indicated that vascular endothelium growth factor (VEGF) is a key player in the progression of angiogenesis and exerts its functions via interaction with tyrosine kinase receptors (TKRs). These receptors could trigger a variety of cascades that lead to the supply of oxygen and nutrients to tumor cells and survival of these cells. With respect to pivotal role of angiogenesis in the tumor growth and survival, finding new therapeutic approaches via targeting angiogenesis could open a new horizon in cancer therapy...
May 25, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28536666/acute-torsion-of-appendicular-mucocele
#5
Farshid Ejtehadi, James Brooks, Hebah Hassan Ali, Vardhini Vijay
We present the case of an 81-year-old man with a known appendicular mucocele who presented to the emergency department with acute abdominal pain. A CT scan showed a change in orientation of the previously seen ovoid mass with surrounding fat stranding suggesting torsion. An emergency laparotomy with appendicectomy and resection of the caecal pole was performed. We discuss the findings and histopathology.
2017: Case Reports in Surgery
https://www.readbyqxmd.com/read/28531651/synthesis-and-characterization-of-au-nps-supported-on-carbon-nanotubes-application-for-the-ultrasound-assisted-removal-of-radioactive-uo2-2-ions-following-complexation-with-arsenazo-iii-spectrophotometric-detection-optimization-isotherm-and-kinetic-study
#6
Mohammad Hassan Omidi, Farshid Nasiri Azad, Mehrorang Ghaedi, Arash Asfaram, Mohammad Hossein Ahmadi Azqhandi, Lobat Tayebi
The present study devoted to description of efficient removal of radioactive UO2(2+) ions (U(IV)) via complexation with Arsenazo III (ARS III) accelerated by ultrasound-assisted adsorption onto the Au-NPs supported on carbon nanotubes (Au-NPs-CNTs), which were characterized by conventional techniques such as FESEM, EDS and XRD. Central composite design (CCD) employed to model contribution of parameters viz. pH (2.5-8.5), adsorbent mass (5-25mg), UO2(2+) concentration (5-25mgL(-1)) and sonication time (1-5min) onto response...
May 13, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28521210/selective-thermal-transformation-of-old-computer-printed-circuit-boards-to-cu-sn-based-alloy
#7
Ali Shokri, Farshid Pahlevani, Ivan Cole, Veena Sahajwalla
This study investigates, verifies and determines the optimal parameters for the selective thermal transformation of problematic electronic waste (e-waste) to produce value-added copper-tin (Cu-Sn) based alloys; thereby demonstrating a novel new pathway for the cost-effective recovery of resources from one of the world's fastest growing and most challenging waste streams. Using outdated computer printed circuit boards (PCBs), a ubiquitous component of e-waste, we investigated transformations across a range of temperatures and time frames...
May 15, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28516069/is-it-necessary-to-perform-nephrostography-before-tube-removal-after-percutaneous-nephrolithotomy
#8
Mehrdad Mohammadi Sichani, Masih Babaeian, Saeid Haghdani, Farshid Alizadeh, Hamid Mazdak, Mazaher Hadi, Mohammadhatef Khorrami
BACKGROUND: The aim of this study is the caparison of the complications rate among the patients which underwent nephrostomy removal with and without performing nephrostography. MATERIALS AND METHODS: Between October 2010 and November 2011, 200 patients who underwent standard percutaneous nephrolithotomy (PCNL) procedures were included in this study. The patients were randomly assigned into two groups, Group A (n = 100) did not undergo the antegrade nephrostography on postoperative day 2 and the patients were discharged keeping the nephrostomy until postoperative day 3, while in Group B (n = 100) the nephrostomy tube was removed on postoperative day 3 after antegrade nephrostography demonstrating ureteral drainage down to the bladder...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28515763/poly-ethylene-co-vinyl-alcohol-based-polymeric-thermo-responsive-nanocarriers-for-controlled-delivery-of-epirubicin-to-hepatocellular-carcinoma
#9
Farshid Hassanzadeh, Maryam Farzan, Jaleh Varshosaz, Ghadam Ali Khodarahmi, Sahar Maaleki, Mahboubeh Rostami
In this study, poly(ethylene-co-vinyl alcohol) (EVOH) as a novel biocompatible polymeric scaffold was surface modified by succinylation to get EVOHS and further pegylated to improve structural properties using methoxypolyethylene glycol (5000 Da) succinate (PEGS) along with targeting with retinoic acid (RA) to get final modified active and passive targeted conjugate (PEGS-EVOHS-RA) to evaluate its ability in carrying and delivery of epirubicin to hepatocellular carcinoma cell lines in response to varying temperatures...
April 2017: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28512869/patterns-of-head-and-neck-sarcoma-in-australia
#10
Roger H Woods, J Alexa Potter, Jessica L Reid, Jennie Louise, Taryn Bessen, Gelareh Farshid, Susan J Neuhaus
BACKGROUND: Sarcomas affecting the head and neck often require complex management due to the combination of anatomic, aesthetic and oncological considerations. The incidence and patterns of presentation are poorly understood and have not been reviewed in the Australian population. METHOD: This study sourced incidence and demographic data from the National Cancer Registry at the Australian Institute of Health and Welfare for the years 1982-2009 (corresponding to 97...
May 16, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28511150/disparities-in-cancer-stage-at-diagnosis-and-survival-of-aboriginal-and-non-aboriginal-south-australians
#11
David Banham, David Roder, Dorothy Keefe, Gelareh Farshid, Marion Eckert, Margaret Cargo, Alex Brown
BACKGROUND/AIM: This study tested the utility of retrospectively staging cancer registry data for comparing stage and stage-specific survivals of Aboriginal and non-Aboriginal people. Differences by area level factors were also explored. METHODS: This test dataset comprised 950 Aboriginal cases and all other cases recorded on the South Australian cancer registry with a 1977-2010 diagnosis. A sub-set of 777 Aboriginal cases diagnosed in 1990-2010 were matched with randomly selected non-Aboriginal cases by year of birth, diagnostic year, sex, and primary site of cancer...
May 13, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28503279/incidence-and-risk-factors-for-cytomegalovirus-in-kidney-transplant-patients-in-babol-northern-iran
#12
Arefeh Babazadeh, Mostafa Javanian, Farshid Oliaei, Roghayeh Akbari, Abazar Akbarzadepasha, Ali Bijani, Mahmoud Sadeghi
BACKGROUND: Cytomegalovirus (CMV) disease is an important cause of death and possibly transplant rejection in kidney transplant (KT) patients. This study was conducted to investigate the incidence and risk factors of CMV disease in kidney transplant patients. METHODS: All end-stage renal disease (ESRD) patients who underwent kidney transplantation during 1998-2014 and their donors were assessed. All samples were followed-up for approximately 70 months. CMV was identified by polymerase chain reaction (PCR) and/or PP65 antigen in peripheral blood leukocytes along with clinical manifestations...
2017: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/28488380/addition-of-oxaliplatin-to-neoadjuvant-radiochemotherapy-in-mri-defined-t3-t4-or-n-rectal-cancer-a-randomized-clinical-trial
#13
Peiman Haddad, Monir Miraie, Farshid Farhan, Mohammad-Sadegh Fazeli, Afsaneh Alikhassi, Afsaneh Maddah-Safaei, Mahdi Aghili, Bita Kalaghchi, Mohammad Babaei
BACKGROUND: Clinical trials investigating the effects of addition of oxaliplatin to neoadjuvant radiochemotherapy in locally advanced rectal cancers (LARCs) have brought controversial results for pathologic complete response as an endpoint. This randomized clinical trial investigated downstaging as a short-term surrogate for progression-free survival (PFS). METHODS: Patients with magnetic resonance imaging (MRI) defined T3, T4 or N+ histologically proven adenocarcinoma of rectum within 15 cm from anal verge were randomly assigned to receive 50-50...
May 10, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28473893/effects-of-silver-nanoparticles-on-staphylococcus-aureus-contaminated-open-wounds-healing-in-mice-an-experimental-study
#14
Masood Adibhesami, Malahat Ahmadi, Amir Abbas Farshid, Farshid Sarrafzadeh-Rezaei, Bahram Dalir-Naghadeh
The microorganisms have been noted as the main cause of delayed wound healing. The most common pathogen causing the wound infections is Staphylococcus aureus. Silver nanoparticles (AgNPs) show ample antibacterial activities. In the present study, the effect of AgNPs on mouse wounds inoculated with S. aureus was investigated. Sixty male mice (20 to 30 g) were anesthetized, full-thickness skin wounds were made on their back and then the bacterial suspension was added to each wound bed. Treatments were administered on wound bed topically including gentamicin (8 mg kg(-1)), AgNPs (0...
2017: Veterinary Research Forum
https://www.readbyqxmd.com/read/28472908/targeted-nanostructured-lipid-carriers-for-delivery-of-paclitaxel-to-cancer-cells-preparation-characterization-and-cell-toxicity
#15
Mahboubeh Rezazadeh, Jaber Emami, Farshid Hassanzadeh, Hojjat Sadeghi, Mahboubeh Rostami, Hamid Mohammadkhani
Low water solubility, high systemic toxicity and insignificant cellular uptake has limited efficient clinical applications of the anti-tumor agent paclitaxel (PTX). To overcome these limitations, a novel nanostructured lipid carrier (NLC) modified with folic acid (FA) and polyethylene glycol (PEG) was prepared by emulsion solvent evaporation method using cholesterol, α-tocopherol, lecithin and Poloxamer. A partial factorial design was applied to determine the appropriate levels of variables for optimized formulation...
May 3, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28465812/breast-cancer-research-in-iran-a-scientometric-analysis-of-publications-output-from-1991-to-2015-in-scopus
#16
Mozhdeh Zarei, Mohammad Iraj Bagheri-Saweh, Masoud Rasolabadi, Ronak Vakili, Jamal Seidi, Marya Maryam Kalhor, Farshid Etaee, Alireza Gharib
INTRODUCTION: As a common type of malignancy, breast cancer is one of the major causes of death in women globally. The purpose of the current study was to analyze Iran research performance on Breast Cancer in the context of national and international studies, shown in the publications indexed in Scopus database during 1991-2015. METHODS: Data were retrieved from the Scopus citation database in this scientometric study. The following string was employed; "breast cancer OR breast malignancy OR breast tumor OR mammary ductal carcinoma" keywords in the main title, abstract and keywords and Iran in the affiliation field were the main related keywords...
February 2017: Electronic Physician
https://www.readbyqxmd.com/read/28457885/genome-engineering-of-stem-cells-for-autonomously-regulated-closed-loop-delivery-of-biologic-drugs
#17
Jonathan M Brunger, Ananya Zutshi, Vincent P Willard, Charles A Gersbach, Farshid Guilak
Chronic inflammatory diseases such as arthritis are characterized by dysregulated responses to pro-inflammatory cytokines such as interleukin-1 (IL-1) and tumor necrosis factor α (TNF-α). Pharmacologic anti-cytokine therapies are often effective at diminishing this inflammatory response but have significant side effects and are used at high, constant doses that do not reflect the dynamic nature of disease activity. Using the CRISPR/Cas9 genome-engineering system, we created stem cells that antagonize IL-1- or TNF-α-mediated inflammation in an autoregulated, feedback-controlled manner...
May 9, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28455369/complement-c5ar1-signaling-promotes-polarization-and-proliferation-of-embryonic-neural-progenitor-cells-through-pkc%C3%AE
#18
Liam G Coulthard, Owen A Hawksworth, Rui Li, Anushree Balachandran, John D Lee, Farshid Sepehrband, Nyoman Kurniawan, Angela Jeanes, David G Simmons, Ernst Wolvetang, Trent M Woodruff
The complement system, typically associated with innate immunity, is emerging as a key controller of non-immune systems including in development, with recent studies linking complement mutations with neurodevelopmental disease. A key effector of the complement response is the activation fragment C5a which, through its receptor C5aR1, is a potent driver of inflammation. Surprisingly, C5aR1 is also expressed during early mammalian embryogenesis, however no clearly defined function is ascribed to C5aR1 in development...
April 28, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28441793/patterns-beliefs-norms-and-perceived-harms-of-hookah-smoking-in-north-iran
#19
Rahman Berdi Ozouni Davaji, Yousef Dadban Shahamat, Farshid Hajili Davaji, Kamal Mirkarimi, Abdurrahman Charkazi, Bagher Pahlavanzadeh, Navisa Sadat Seydghasemi, Gholamreza Sharifirad, Mitra Moodi, Ayoub Elahi
Introduction: Hookah smoking is considered as a public health threat around the globe. The aim of this study was to investigatethe hookah smoking patterns, beliefs, norms and perceived harms in Golestan province of Iran. Methods: A cross-sectional study was conducted on 395 hookah smokers using convenience sampling method in 2015. To collect data, Heinz’s hookah patternwas utilized. Ordinal regression models were used to exploring of covariates related to the odds of life time, last-30-day, and current hookah use...
March 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28440306/an-evaluation-of-factors-associated-with-pathogenic-prss1-spink1-ctfr-and-or-ctrc-genetic-variants-in-patients-with-idiopathic-pancreatitis
#20
Niloofar Y Jalaly, Robert A Moran, Farshid Fargahi, Mouen A Khashab, Ayesha Kamal, Anne Marie Lennon, Christi Walsh, Martin A Makary, David C Whitcomb, Dhiraj Yadav, Liudmila Cebotaru, Vikesh K Singh
OBJECTIVES: We evaluated factors associated with pathogenic genetic variants in patients with idiopathic pancreatitis. METHODS: Genetic testing (PRSS1, CFTR, SPINK1, and CTRC) was performed in all eligible patients with idiopathic pancreatitis between 2010 to 2015. Patients were classified into the following groups based on a review of medical records: (1) acute recurrent idiopathic pancreatitis (ARIP) with or without underlying chronic pancreatitis; (2) idiopathic chronic pancreatitis (ICP) without a history of ARP; (3) an unexplained first episode of acute pancreatitis (AP)<35 years of age; and (4) family history of pancreatitis...
April 25, 2017: American Journal of Gastroenterology
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