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https://www.readbyqxmd.com/read/27913302/to-the-editor-combined-immunodeficiency-and-hypoglycemia-associated-with-mutations-in-hypoxia-up-regulated-1
#1
Emma M Haapaniemi, Christopher L Fogarty, Salla Keskitalo, Shintaro Katayama, Helena Vihinen, Mette Ilander, Satu Mustjoki, Kaarel Krjutškov, Markku Lehto, Timo Hautala, Ove Eriksson, Eija Jokitalo, Vidya Velagapudi, Markku Varjosalo, Mikko Seppänen, Juha Kere
We describe recessive mutations in hypoxia up-regulated 1 (HYOU1) in a patient that presented with generalized susceptibility to bacterial and herpetic infections as well as hypoglycemic episodes.
November 29, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27799870/proteomic-profiling-of-lung-adenocarcinoma-indicates-heightened-dna-repair-antioxidant-mechanisms-and-identifies-lasp1-as-a-potential-negative-predictor-of-survival
#2
Johannes F Fahrmann, Dmitry Grapov, Brett S Phinney, Carol Stroble, Brian C DeFelice, William Rom, David R Gandara, Yanhong Zhang, Oliver Fiehn, Harvey Pass, Suzanne Miyamoto
BACKGROUND: Lung cancer is the leading cause of cancer mortality in the United States. Non-small cell lung cancer accounts for 85% of all lung cancers for which adenocarcinoma is the most common histological type. Management of lung cancer is hindered by high false-positive rates due to difficulty resolving between benign and malignant tumors. Better molecular analysis comparing malignant and non-malignant tissues will provide important evidence of the underlying biology contributing to tumorigenesis...
2016: Clinical Proteomics
https://www.readbyqxmd.com/read/26918051/hyou1-regulated-by-lplunc1-is-up-regulated-in-nasopharyngeal-carcinoma-and-associated-with-poor-prognosis
#3
Yujuan Zhou, Qianjin Liao, Xiayu Li, Hui Wang, Fang Wei, Jie Chen, Jing Yang, Zhaoyang Zeng, Xiaofang Guo, Pan Chen, Wenling Zhang, Ke Tang, Xiaoling Li, Wei Xiong, Guiyuan Li
OBJECTIVE: This study aims to investigate the roles and mechanisms of long palate, lung and nasal epithelium clone 1 (LPLUNC1) in nasopharyngeal carcinoma (NPC). METHODS: The two-dimensional fluorescence difference gel electrophoresis (2-D DIGE) and matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF-TOF-MS/MS) was applied to identify differentially expressed proteins after over-expressing LPLUNC1 in NPC cells. The qRT-PCR and Western Blot were used to further validate differentially expression of Hypoxia up-regulated 1 (HYOU1)...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/26794603/novel-elements-of-the-chondrocyte-stress-response-identified-using-an-in-vitro-model-of-mouse-cartilage-degradation
#4
Richard Wilson, Suzanne B Golub, Lynn Rowley, Constanza Angelucci, Yuliya V Karpievitch, John F Bateman, Amanda J Fosang
The destruction of articular cartilage in osteoarthritis involves chondrocyte dysfunction and imbalanced extracellular matrix (ECM) homeostasis. Pro-inflammatory cytokines such as interleukin-1α (IL-1α) contribute to osteoarthritis pathophysiology, but the effects of IL-1α on chondrocytes within their tissue microenvironment have not been fully evaluated. To redress this we used label-free quantitative proteomics to analyze the chondrocyte response to IL-1α within a native cartilage ECM. Mouse femoral heads were cultured with and without IL-1α, and both the tissue proteome and proteins released into the media were analyzed...
March 4, 2016: Journal of Proteome Research
https://www.readbyqxmd.com/read/26388988/integrated-transcriptional-profiling-and-genomic-analyses-reveal-rpn2-and-hmgb1-as-promising-biomarkers-in-colorectal-cancer
#5
Jialing Zhang, Bin Yan, Stephan Stanislaw Späth, Hu Qun, Shaleeka Cornelius, Daogang Guan, Jiaofang Shao, Koichi Hagiwara, Carter Van Waes, Zhong Chen, Xiulan Su, Yongyi Bi
Colorectal cancer (CRC) is a heterogeneous disease that is associated with a gradual accumulation of genetic and epigenetic alterations. Among all CRC stages, stage II tumors are highly heterogeneous with a high relapse rate in about 20-25 % of stage II CRC patients following surgery. Thus, a comprehensive analysis of gene signatures to identify aggressive and metastatic phenotypes in stage II CRC is desired for a more accurate disease classification and outcome prediction. By utilizing a Cancer Array, containing 440 oncogenes and tumor suppressors to profile mRNA expression, we identified a larger number of differentially expressed genes in poorly differentiated stage II colorectal adenocarcinoma tissues, compared to their matched normal tissues...
2015: Cell & Bioscience
https://www.readbyqxmd.com/read/25976356/expression-profiles-of-select-genes-in-cumulus-oocyte-complexes-from-young-and-aged-mares
#6
Lindsay Cox, Dirk K Vanderwall, Kate C Parkinson, Alexis Sweat, S Clay Isom
There is compelling evidence that oocytes from mares >18 years of age have a high incidence of inherent defects that result in early embryonic loss. In women, an age-related decrease in oocyte quality is associated with an increased incidence of aneuploidy and it has recently been determined that the gene expression profile of human oocytes is altered with advancing age. We hypothesised that similar age-related aberrations in gene expression occur in equine oocytes. Therefore, the aim of the present study was to compare gene expression profiles of individual oocytes and cumulus cells from young and aged mares, specifically evaluating genes that have been identified as being differentially expressed with advancing maternal age and/or aneuploidy in human oocytes...
July 2015: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/25815715/quantification-of-the-host-response-proteome-after-herpes-simplex-virus-type-1-infection
#7
Alicia R Berard, Kevin M Coombs, Alberto Severini
Viruses employ numerous host cell metabolic functions to propagate and manage to evade the host immune system. For herpes simplex virus type 1 (HSV1), a virus that has evolved to efficiently infect humans without seriously harming the host in most cases, the virus-host interaction is specifically interesting. This interaction can be best characterized by studying the proteomic changes that occur in the host during infection. Previous studies have been successful at identifying numerous host proteins that play important roles in HSV infection; however, there is still much that we do not know...
May 1, 2015: Journal of Proteome Research
https://www.readbyqxmd.com/read/25405878/assessing-the-impact-of-electrohydrodynamic-jetting-on-encapsulated-cell-viability-proliferation-and-ability-to-self-assemble-in-three-dimensional-structures
#8
Volha Liaudanskaya, Luca Gasperini, Devid Maniglio, Antonella Motta, Claudio Migliaresi
In this article, we propose a systemic approach to investigate the impact of electrohydrodynamic jetting (EHDJ) encapsulation on viability, proliferation, and functionality of the encapsulated cells. EHDJ consists in applying a high-voltage electrical field between a target substrate and a jetting needle, which is fed with a suspension of cells in a polymeric solution undergoing a sol-gel transition upon contact with the target. The viability, proliferation, and self-assembling ability of SHSY5Y human neuroblastoma cell line encapsulated in 2% alginate microbeads were analyzed by confocal microscopy and DNA quantification assays...
June 2015: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/25389441/akebia-trifoliate-thunb-koidz-seed-extract-inhibits-the-proliferation-of-human-hepatocellular-carcinoma-cell-lines-via-inducing-endoplasmic-reticulum-stress
#9
Wen-Li Lu, Hong-Yan Ren, Cao Liang, Yuan-Yuan Zhang, Ji Xu, Zhi-Qiang Pan, Xiao-Mei Liu, Zhong-Hua Wu, Zhao-Qin Fang
Akebia Fructus has long been used for hepatocellular carcinoma (HCC) in China, while the molecular mechanism remains obscure. Our recent work found that Akebia trifoliate (Thunb.) Koidz seed extract (ATSE) suppressed proliferation and induced endoplasmic reticulum (ER) stress in SMMC-7721. The present study aimed to throw more light on the mechanism. ER stress occurred after ATSE treatment in HepG2, HuH7, and SMMC-7721 cells, manifested as ER expansion, and SMMC-7721 was the most sensitive kind in terms of morphology...
2014: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/24920810/modulation-of-kaposi-s-sarcoma-associated-herpesvirus-interleukin-6-function-by-hypoxia-upregulated-protein-1
#10
Louise Giffin, Feng Yan, M Ben Major, Blossom Damania
UNLABELLED: Kaposi's sarcoma-associated herpesvirus (KSHV, also called human herpesvirus 8) is linked to the development of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman's disease (MCD). KSHV expresses several proteins that modulate host cell signaling pathways. One of these proteins is viral interleukin-6 (vIL-6), which is a homolog of human IL-6 (hIL-6). vIL-6 is able to prevent apoptosis and promote proinflammatory signaling, angiogenesis, and cell proliferation...
August 2014: Journal of Virology
https://www.readbyqxmd.com/read/24413982/downregulation-of-proteins-involved-in-the-endoplasmic-reticulum-stress-response-and-nrf2-are-signaling-in-lymphoblastoid-cells-of-spinocerebellar-ataxia-type-17
#11
Li-Ching Lee, Yu-Ting Weng, Yih-Ru Wu, Bing-Wen Soong, Yung-Che Tseng, Chiung-Mei Chen, Guey-Jen Lee-Chen
Spinocerebellar ataxia type 17 (SCA17) is caused by CAG repeat expansion in the TATA-box binding protein gene. Studies of several polyglutamine (polyQ) expansion diseases have suggested that the expanded polyQ proteins misfold and induce oxidative stress to contribute to cell death. Substantial deficits in peripheral tissues including lymphocytes have been shown and these peripheral abnormalities could also be found in neurons possessing polyQ disease proteins. In this study, we used a lymphoblastoid cell model to investigate the functional implication of SCA17 expanded alleles and assess the potential therapeutic strategies that may ameliorate the effects of expanded polyQ...
June 2014: Journal of Neural Transmission
https://www.readbyqxmd.com/read/23780673/tetrandrine-attenuated-cerebral-ischemia-reperfusion-injury-and-induced-differential-proteomic-changes-in-a-mcao-mice-model-using-2-d-dige
#12
Lin Ruan, Huan-Sen Huang, Wen-Xiang Jin, Hai-Ming Chen, Xiong-Juan Li, Qing-Juan Gong
Ischemic stroke is the most common type of stroke and brings about a big disease burden because of high mortality and disability in China. Tetrandrine, a bisbenzylisoquinoline alkaloid isolated from the Chinese herb Radix Stephania tetrandra, has been demonstrated to possess anti-inflammatory and free radical scavenging effects and even regulate astrocyte activation, but the possible role of tetrandrine in ameliorating cerebral ischemia/reperfusion injury of ischemic stroke remains unknown. The aim of this study was to determine the effects of tetrandrine on neurological injury and differential proteomic changes induced by transient reversible middle cerebral artery occlusion (MCAO) in mice...
September 2013: Neurochemical Research
https://www.readbyqxmd.com/read/23333935/a-multifunctional-chimeric-chaperone-serves-as-a-novel-immune-modulator-inducing-therapeutic-antitumor-immunity
#13
Xiaofei Yu, Chunqing Guo, Huanfa Yi, Jie Qian, Paul B Fisher, John R Subjeck, Xiang-Yang Wang
Converting the immunosuppressive tumor environment into one that is favorable to the induction of antitumor immunity is indispensable for effective cancer immunotherapy. Here, we strategically incorporate a pathogen (i.e., flagellin)-derived, NF-κB-stimulating "danger" signal into the large stress protein or chaperone Grp170 (HYOU1/ORP150) that was previously shown to facilitate antigen crosspresentation. This engineered chimeric molecule (i.e., Flagrp170) is capable of transporting tumor antigens and concurrently inducing functional activation of dendritic cells (DC)...
April 1, 2013: Cancer Research
https://www.readbyqxmd.com/read/23144909/treatment-with-the-proteasome-inhibitor-mg132-during-the-end-of-oocyte-maturation-improves-oocyte-competence-for-development-after-fertilization-in-cattle
#14
Jinyoung You, Eunsong Lee, Luciano Bonilla, Jasmine Francis, Jin Koh, Jeremy Block, Sixue Chen, Peter J Hansen
Maturation of the oocyte involves nuclear and cytoplasmic changes that include post-translational processing of proteins. The objective was to investigate whether inhibition of proteasomes during maturation would alter competence of the bovine oocyte for fertilization and subsequent development. Cumulus-oocyte complexes were cultured in the presence or absence of the proteasomal inhibitor MG132 from either 0-6 h or 16-22 h after initiation of maturation. Treatment with MG132 early in maturation prevented progression to meiosis II and reduced fertilization rate and the proportion of oocytes and cleaved embryos that became blastocysts...
2012: PloS One
https://www.readbyqxmd.com/read/22796066/proteomics-and-gene-expression-analyses-of-squalene-supplemented-mice-identify-microsomal-thioredoxin-domain-containing-protein-5-changes-associated-with-hepatic-steatosis
#15
Adela Ramírez-Torres, Sílvia Barceló-Batllori, Roberto Martínez-Beamonte, María A Navarro, Joaquín C Surra, Carmen Arnal, Natalia Guillén, Sergio Acín, Jesús Osada
Squalene is an abundant hydrocarbon present in virgin olive oil. Previous studies showed that its administration decreased atherosclerosis and steatosis in male apoE-knock-out mice. To study its effects on microsomal proteins, 1g/kg/day of squalene was administered to those mice. After 10 weeks, hepatic fat content was assessed and protein extracts of microsomal enriched fractions from control and squalene-treated animals were analyzed by 2D-DIGE. Spots exhibiting significant differences were identified by peptide fingerprinting and MSMS analysis...
December 21, 2012: Journal of Proteomics
https://www.readbyqxmd.com/read/22270012/proteomic-profiling-of-rapid-non-genomic-and-concomitant-genomic-effects-of-acute-restraint-stress-on-rat-thymocytes
#16
Anja M Billing, Dominique Revets, Céline Hoffmann, Jonathan D Turner, Sara Vernocchi, Claude P Muller
In order to investigate rapid non-genomic effects of acute stress, rats were restrained for 15 min which was sufficient to activate the hypothalamus-pituitary-adrenal (HPA) axis but too short to induce massive genomic effects of cortisol. Subcellular fractions of thymocytes (cytosol, nucleus, membrane) were investigated using quantitative 2D DIGE with MALDI-TOF/TOF mass spectrometry. In total, 108 proteins with differential subcellular localizations were identified. The specificity of the changes induced by psychological stress was reflected by the prominent modulation of proteins involved in the HPA and sympathoadrenal medullar (SAM) axis such as HMGB1 and NHERF1...
April 3, 2012: Journal of Proteomics
https://www.readbyqxmd.com/read/21861121/down-regulation-effect-of-rosmarinus-officinalis-polyphenols-on-cellular-stress-proteins-in-rat-pheochromocytoma-pc12-cells
#17
Abdelfatteh E L Omri, Junkyu Han, Manef Ben Abdrabbah, Hiroko Isoda
Polyphenols are known to exhibit wide spectrum of benefit for brain health and to protect from several neurodegenerative diseases. The present study was sought to determine the neuroprotective effects of Rosmarinus officinalis' polyphenols (luteolin, carnosic acid, and rosmarinic acid) through the investigation of stress-related proteins. We carried out measurement of the expression of heat-shock protein (Hsp) 47 promoter in heat stressed Chinese hamster ovary transfected cells. We performed proteomic analysis and confirmed gene expression by real time PCR in PC12 cells...
May 2012: Cytotechnology
https://www.readbyqxmd.com/read/21642380/molecular-chaperones-as-a-common-set-of-proteins-that-regulate-the-invasion-phenotype-of-head-and-neck-cancer
#18
Ching-Chi Chiu, Chien-Yu Lin, Li-Yu Lee, Yin-Ju Chen, Ya-Ching Lu, Hung-Ming Wang, Chun-Ta Liao, Joseph Tung-Chieh Chang, Ann-Joy Cheng
PURPOSE: The goal of this study was to establish a common set of molecules that regulate cell invasion in head and neck cancer (HNC). EXPERIMENTAL DESIGN: Five invasive sublines derived from HNC cell lines were established using the Matrigel selection method. Proteomic technology, MetaCore algorithm, and reverse transcriptase-PCR methods were used to search for molecules that contribute to the invasion phenotype. Cellular functional analyses and clinical association studies were applied to examine the significance of the molecules...
July 15, 2011: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/21308111/proteomics-analysis-identifies-park7-as-an-important-player-for-renal-cell-resistance-and-survival-under-oxidative-stress
#19
Marwa Eltoweissy, Gerhard A Müller, Asima Bibi, Phuc Van Nguye, Gry H Dihazi, Claudia A Müller, Hassan Dihazi
Renal fibrosis is a process that is characterized by declining excretory renal function. The molecular mechanisms of fibrosis are not fully understood. Oxidative stress pathways were reported to be involved in renal tissue deterioration and fibrosis progression. In order to identify new molecular targets associated with oxidative stress and renal fibrosis, differential proteomics analysis was performed with established renal cell lines (TK173 and HK-2). The cells were treated with oxidative stress triggering factor H(2)O(2) and the proteome alterations were investigated...
April 2011: Molecular BioSystems
https://www.readbyqxmd.com/read/21118732/proteomics-characterization-of-cell-model-with-renal-fibrosis-phenotype-osmotic-stress-as-fibrosis-triggering-factor
#20
Hassan Dihazi, Gry Helene Dihazi, Claudia Mueller, Loubna Lahrichi, Abdul R Asif, Asima Bibi, Marwa Eltoweissy, Radovan Vasko, Gerhard A Mueller
Renal fibroblasts are thought to play a major role in the development of renal fibrosis (RF). The mechanisms leading to this renal alteration remain poorly understood. We performed differential proteomic analyses with two established fibroblast cell lines with RF phenotype to identify new molecular pathways associated with RF. Differential 2-DE combined with mass spectrometry analysis revealed the alteration of more than 30 proteins in fibrotic kidney fibroblasts (TK188) compared to normal kidney fibroblast (TK173)...
March 1, 2011: Journal of Proteomics
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