Simone Serio, Christina Pagiatakis, Elettra Musolino, Arianna Felicetta, Pierluigi Carullo, Javier Laura Frances, Laura Papa, Giacomo Rozzi, Nicolò Salvarani, Michele Miragoli, Rosalba Gornati, Giovanni Bernardini, Gianluigi Condorelli, Roberto Papait
BACKGROUND: Heart failure is typical in the elderly. Metabolic remodeling of cardiomyocytes underlies inexorable deterioration of cardiac function with aging: glycolysis increases at the expense of oxidative phosphorylation, causing an energy deficit contributing to impaired contractility. Better understanding of the mechanisms of this metabolic switching could be critical for reversing the condition. METHODS: To investigate the role of 3 histone modifications (H3K27ac, H3K27me3, and H3K4me1) in the metabolic remodeling occurring in the aging heart, we cross-compared epigenomic, transcriptomic, and metabolomic data from mice of different ages...
September 29, 2023: Circulation Research